Specific embodiment
In order to make the above objects, features, and advantages of the present application more apparent, below to the specific reality of the applicationThe mode of applying is described in detail.Many details are explained in the following description in order to fully understand the application.ButThe application can be implemented with being much different from other way described herein, and those skilled in the art can be without prejudice to this ShenSimilar improvement please be done in the case where intension, therefore the application is not limited by the specific embodiments disclosed below.
It should be noted that it can be directly another when element is referred to as " being fixed on " or " being set to " another elementOn one element or there may also be elements placed in the middle.When an element is considered as " connection " another element, it can be withIt is directly to another element or may be simultaneously present centering elements.Term as used herein " vertically ", " level", "left", "right" and similar statement for illustrative purposes only, be not meant to be the only embodiment.
Unless otherwise defined, all technical and scientific terms used herein and the technical field for belonging to the applicationThe normally understood meaning of technical staff is identical.The term used in the description of the present application is intended merely to description tool hereinThe purpose of the embodiment of body, it is not intended that in limitation the application.Term as used herein "and/or" includes one or moreAny and all combinations of relevant listed item.
In the application one embodiment, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming of liquidAgent, and the cleaning agent and the film forming agent are separately positioned；The cleaning agent and the film forming agent all have constituent of chitosan；ItsIn, it is 0.5%~5% constituent of chitosan that the cleaning agent, which has mass ratio,；It is 2% that the film forming agent, which has mass ratio,~12% constituent of chitosan.On the one hand above-mentioned chitosan liquid dressing uses cleaning agent and film forming agent is setting for liquidMeter, when use, are very convenient, and spray pattern application, which both can be used, also can be used application pattern application；On the other hand difference is usedThe constituent of chitosan of mass ratio realizes cleaning, sterilization, isolation and protection effect；Another aspect uses cleaning agent and film formingThe design of agent separation can realize wound cleaning only with cleaning agent, then realize wound isolating and protecting using film forming agent；FurtherAspect can debridement form a film during retain wound diffusate, moist environment needed for quick healing of cut is provided, fromAnd be conducive to wound recovery.
It is 1%~4% constituent of chitosan that the cleaning agent, which has mass ratio, in one of the embodiments,.At itIn middle one embodiment, it is 3%~10% constituent of chitosan that the film forming agent, which has mass ratio,.One embodiment whereinIn, it is 2%~4% constituent of chitosan that the cleaning agent, which has mass ratio,；The cleaning agent in one of the embodiments,The constituent of chitosan for being 1%~2% with mass ratio；The cleaning agent has mass ratio in one of the embodiments,For 1.6%~2% constituent of chitosan；In one of the embodiments, the cleaning agent have mass ratio be 1%,1.5%, 1.6%, 1.8%, 2%, 3%, 4% or 5% constituent of chitosan；And/or it is described in one of the embodiments,It is 5%~10% constituent of chitosan that film forming agent, which has mass ratio,.The film forming agent has matter in one of the embodiments,The constituent of chitosan that amount ratio is 2%~5%.It is 2.4% that the film forming agent, which has mass ratio, in one of the embodiments,~3.8% constituent of chitosan.In one of the embodiments, the film forming agent have mass ratio be 2%, 2.4%,2.5%, 3%, 3.8%, 5%, 6%, 7%, 8%, 9%, 10%, 11% or 12% constituent of chitosan.A reality whereinIt applies in example, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaning agent and it is described atFilm all has constituent of chitosan；Wherein, it is 2%~4% constituent of chitosan that the cleaning agent, which has mass ratio,；It is described atIt is 5%~10% constituent of chitosan that film, which has mass ratio,.The cleaning agent has quality in one of the embodiments,The constituent of chitosan that ratio is 1.6%~2%, it is 2%~5% constituent of chitosan that the film forming agent, which has mass ratio,.?In one embodiment, a kind of chitosan liquid dressing comprising the cleaning agent of liquid and the film forming agent of liquid；The cleaningAgent and the film forming agent all have constituent of chitosan；Wherein, it is 2% constituent of chitosan that the cleaning agent, which has mass ratio,；It is 6% constituent of chitosan that the film forming agent, which has mass ratio,.The cleaning agent has quality in one of the embodiments,The constituent of chitosan that ratio is 4%；It is 8% constituent of chitosan that the film forming agent, which has mass ratio,.An implementation whereinIn example, it is 3% constituent of chitosan that the cleaning agent, which has mass ratio,；It is 7% shell that the film forming agent, which has mass ratio,Chitosan component.It is 3.5% constituent of chitosan that the cleaning agent, which has mass ratio, in one of the embodiments,；It is described atIt is 9% constituent of chitosan that film, which has mass ratio,.The cleaning agent is with mass ratio in one of the embodiments,2.5% constituent of chitosan；It is 10% constituent of chitosan that the film forming agent, which has mass ratio,.One embodiment whereinIn, it is 4% constituent of chitosan that the cleaning agent, which has mass ratio,；The film forming agent has the shell that mass ratio is 5% poly-Sugared ingredient.Remaining embodiment and so on.Further, in each embodiment, the constituent of chitosan content of the film forming agent is higher thanThe constituent of chitosan of the cleaning agent.Further, in each embodiment, example in mass ratio, the constituent of chitosan of the film forming agentIt is 2 times of the constituent of chitosan of the cleaning agent.
The cleaning agent is the physiological saline with constituent of chitosan in one of the embodiments,.Physiological saline refers toThe of substantially equal sodium chloride solution of the osmotic pressure of Physiology Experiment or clinically common osmotic pressure and animal or human plasma, is used0.85~0.9% when mammal and human body, osmotic pressure is approximate with blood of human body, the content of sodium also with blood plasma phaseClosely, but the content of chlorine is apparently higher than the content of chlorine in blood plasma, can external application, as applied when clean wound or dressing.The cleaningIt is 0.5%~5% constituent of chitosan that agent, which has mass ratio, i.e., it is 0.5%~5% shell that physiological saline, which has mass ratio,Chitosan component, remaining embodiment and so on.The cleaning agent further includes suitable phosphoric acid hydrogen two in one of the embodiments,Sodium and/or sodium dihydrogen phosphate.Such design is made so that the cleaning agent has preferably to rinse, clean, moisturize and sterilize etc.With.
It is 0.01%~0.05% that the cleaning agent, which is the mass ratio with constituent of chitosan, in one of the embodiments,Benza.Benzalkonium chloride (BenzaLkonium chLoride) chemical name is chlorodimethyl benzyl hydrocarbon ammonium, is belonged toIt is wide-spectrum bactericide in cation quaternary ammonium salt type surfactant, bacterial cytoplasm membrane permeability can be changed, makes outside thallus endochylema substanceIt seeps, it is hindered to be metabolized and play killing effect.It is stronger to gram-positive bacteria effect, to Pseudomonas aeruginosa, acid-fast bacilli and cell budBorn of the same parents are invalid, can be combined rapidly with protein, and in the presence of meeting blood, cotton, cellulose and organic matter, effect is significantly reduced；Usually0.1% or less concentration is suitable for pre-surgical skin disinfection, mucous membrane and wound disinfection to no skin irritation.A reality whereinApply in example, the cleaning agent be the mass ratio with constituent of chitosan be 0.01%, 0.02%, 0.03%, 0.04% or0.05% Benza.
The cleaning agent is the second that the volume ratio with constituent of chitosan is 70%~75% in one of the embodiments,Alcoholic solution.70%~75% ethanol solution is commonly referred to as alcohol, and the polarity of hydroxyl is but also many ionic compounds in ethyl alcoholIt dissolves in ethanol solution.In one of the embodiments, the cleaning agent be the volume ratio with constituent of chitosan be 70%,71%, 72%, 73%, 74% or 75% ethanol solution.Such cleaning agent volatility is preferable, and residual degree is low, especially suitableCooperation is that cleaning agent uses.
The cleaning agent is the iodine that the mass ratio with constituent of chitosan is 0.5%~1% in one of the embodiments,Lie prostrate solution.Iodophor is that the indefinite form conjugate of iodine and polyvinylpyrrolidone (Povidone) is also known as complex compound, is had wideBactericidal effect is composed, bacterial propagule, fungi, protozoon and fractionated viral can be killed, therefore be medically used as disinfection sanitizer, it canFor the disinfection of skin, mucous membrane, scald, treatment trichomonas vaginitis, colpomycosis, skin fungus infection can also be handledDeng, it may also be used for the disinfection of operation consent and other skins, various injection site skin degermings, instrument soaking disinfection and vagina handPreoperative disinfection etc..Iodophor and the tincture of iodine are all disinfectants, and efficacy component is iodine, but the tincture of iodine is using ethanol solution as solvent, iodineVolt is using water as solvent, and the two effect is identical, and Iodophor is also wider than the purposes of the tincture of iodine in some sense.Since Iodophor isIt is made using water of solvent, therefore there is no irritation to skin, mucous membrane, wound, this is its place more outstanding than the tincture of iodine.Now generally useIn muscle, intravenous injection, external application, perform the operation skin disinfectant.The cleaning agent is poly- with shell in one of the embodiments,The iodophor solution that the mass ratio of sugared ingredient is 0.5%, 0.6%, 0.7%, 0.8%, 0.9% or 1%.Further, whereinIn one embodiment, it is wide that the cleaning agent, which is the Betagen Solution that the mass ratio with constituent of chitosan is 3%~5%,The powerful disinfectant of spectrum has stronger killing effect to virus, bacterium, fungi and mycotic spore, and to skin irritatinProperty it is small, toxicity is low, persistent, and use is safe and simple, substantially nonirritant to organizing, and sterilizes for skin and mucous membrane, such as handPreoperative cleaning, operative site and wound disinfection.
In order to promote bactericidal anti-inflammatory effect, further, the cleaning agent and/or described in one of the embodiments,Film forming agent includes or further includes the silvery agent that mass ratio is 0.01%~0.1%, i.e., the described cleaning agent includes or further includes matterAmount ratio be 0.01%~0.1% silvery agent, and/or, the film forming agent include or further include mass ratio be 0.01%~0.1% silvery agent.The silvery agent includes nano silver in one of the embodiments,.It is described in one of the embodiments,Silvery agent includes silver ion alginates.In experiments it is found that silver ion alginates cooperation constituent of chitosan has fabulous sterilizationAnti-inflammatory synergistic effect, can effectively kill the miscellaneous bacteria of wound surface, wound is made to avoid the infection of the bacterial strains such as bacterium, fungi, gemma.
Film forming agent is also known as coalescing agent, is capable of forming the polymer of continuous film；In one of the embodiments, it is described atFilm is Watery film-fomer.The film forming agent is selected from albumen film forming agent in one of the embodiments, acrylic resin forms a filmOne of agent, polyethylene kind copolymer, hydrocarbon type copolymer, organosilicon polymer or Si acrylate are a variety of.Wherein oneIn a embodiment, the film forming agent is complexing agent comprising a variety of film forming agents are used in mixed way.Institute in one of the embodiments,Stating film forming agent includes albumen film forming agent, acrylic resin film forming agent, polyethylene kind copolymer, hydrocarbon type copolymer, polymerizable organosiliconAt least two in object and Si acrylate.The film forming agent includes that sodium alginate and gelatin are molten in one of the embodiments,Liquid, chitosan is miscible or is suspended in sodium alginate and gelatin solution, it will be understood that in the cleaning agent and the film forming agentWith moisture appropriate.The film forming agent includes the glycerine that mass ratio is 1%~12% in one of the embodiments,；The film forming agent includes the polyethylene glycol that mass ratio is 1%~8% in one of the embodiments,；An implementation whereinIn example, the film forming agent includes the hyaluronic acid that mass ratio is 0.1%~0.5%；In one of the embodiments, it is described atFilm includes basic fibroblast growth factor (the basic FibrobLast that mass ratio is 0.01%~0.05%Growth Factor, bFGF) or epidermal growth factor (EpidermaL Growth Factor, EGF)；An implementation whereinIn example, the film forming agent includes the sodium alginate that mass ratio is 8%~20%；The film forming in one of the embodiments,Agent includes the collagen or human-like collagen that mass ratio is 0.2%~0.8%；In each embodiment, tradition also can be usedThe related film forming agent of formula.Further, the film forming agent includes or further includes that mass ratio is in one of the embodiments,Hyaluronic acid that 1%~12% glycerine, mass ratio are 0.1%~0.5%, mass ratio are 0.01%~0.05%The sodium alginate that basic fibroblast growth factor and mass ratio are 8%~20%；It is described in one of the embodiments,Film forming agent include or further include mass ratio be 4% glycerine, mass ratio be 0.2% hyaluronic acid, mass ratio beThe sodium alginate that 0.04% basic fibroblast growth factor and mass ratio is 9%；Institute in one of the embodiments,State film forming agent include mass ratio be 10% constituent of chitosan, mass ratio be 4% glycerine, mass ratio 0.2%Hyaluronic acid, mass ratio be 0.04% basic fibroblast growth factor and mass ratio be 9% sodium alginate,Surplus is for example medical pure water of pure water；Remaining embodiment and so on.
To promote Wound healing, further, the film forming agent includes or further includes quality in one of the embodiments,The brown alga oligose that ratio is 1%~5%, brown alga oligose cooperate constituent of chitosan in film forming agent, are conducive to induce and improve thinIntracellular growth activity, promotes fibroblastic transfer and increment, improves local microcirculation, creates suitable cell growing environment,To wound healing.In one of the embodiments, the film forming agent include or further include mass ratio be 1%, 2%,3%, 4% or 5% brown alga oligose.Further, example, the film forming agent include in mass ratio in one of the embodiments,2%~12% constituent of chitosan, 1%~12% glycerine, 0.1%~0.5% hyaluronic acid, 0.01%~0.05%Basic fibroblast growth factor, 8%~20% sodium alginate and 1%~5% brown alga oligose, surplus be it is pureWater；Example in mass ratio in one of the embodiments, the film forming agent include 4%~10% constituent of chitosan, 2%~8%Glycerine, 0.2%~0.4% hyaluronic acid, 0.02%~0.04% basic fibroblast growth factor, 10%~12% sodium alginate and 2%~4% brown alga oligose, surplus is pure water；In one of the embodiments, in mass ratioExample, the film forming agent include 6% constituent of chitosan, 5% glycerine, 0.3% hyaluronic acid, 0.03% alkalinity into fibreTieing up Porcine HGF, 11% sodium alginate and 3% brown alga oligose, surplus is pure water；Remaining embodiment and so on.
For promoted wound blood coagulation haemostatic effect, further, in one of the embodiments, the film forming agent include orIt further include the hemostasis auxiliary material that mass ratio is 0.1%~1%.The film forming agent includes or also wraps in one of the embodiments,Include the hemostasis auxiliary material that mass ratio is 0.1%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8% or 1%.An implementation whereinIn example, the hemostasis auxiliary material includes coagulation factor；Coagulation factor is the various protein components for participating in Blood Coagulation Process, lifeReason effect is: is activated together with platelet adhesion in angiorrbagia and mends the leak on plug blood vessel.This process quiltReferred to as blood coagulation.Entire coagulation process can generally be divided into two stages, the activation of factor and the fibrinous shape of gelAt.It is (1~2): 1 fibrinogen and fibrin ferment that the coagulation factor, which includes mass ratio, in one of the embodiments,It is former；In one of the embodiments, the coagulation factor include mass ratio be (1~2): 1:(1~2) fibrinogen,Factor and the calcium factor.The hemostasis auxiliary material further includes Fibrin Glue in one of the embodiments,；A reality whereinIt applies in example, the hemostasis auxiliary material further includes micropore polysaccharide styptic powder；The hemostasis auxiliary material also wraps in one of the embodiments,Include fibrin ferment.In one of the embodiments, the hemostasis auxiliary material include mass ratio be (1~2): 1 Fibrin Glue withCoagulation factor.In one of the embodiments, it is described hemostasis auxiliary material include mass ratio be (1~2): 1:(1~2) fiber eggWhite glue, coagulation factor and micropore polysaccharide styptic powder.The hemostasis auxiliary material includes that mass ratio is in one of the embodiments,(1~2): 1:1:(1~2) Fibrin Glue, fibrin ferment particle, coagulation factor and micropore polysaccharide styptic powder.It is such to setOn the one hand hemostasis auxiliary material is dexterously designed into film forming agent by meter, in first time contact blood source to generate blood coagulation anastalsis,On the other hand be conducive to trigger intrinsic coagulation system acute activation by hemostasis auxiliary material and promote the generation of fibrin ferment, then existUnder the action of fibrin ferment, the accelerated hydrolysis of fibrinogen reinforces to form insoluble fibrin through fibrin stabilizing factorPolymer is advantageously implemented wound healing to realize hemostasis and prevent the effect of tissue adhesion on this basis.
For promoted wound blood coagulation haemostatic effect, further, in one of the embodiments, the film forming agent include orIt further include the amino acid that mass ratio is 0.1%~0.4%.The film forming agent includes or also wraps in one of the embodiments,Include the amino acid that mass ratio is 0.1%, 0.2%, 0.3% or 0.4%.The amino acid packet in one of the embodiments,Include at least one of threonine, valine and tryptophan；The amino acid is threonine, figured silk fabrics in one of the embodiments,Propylhomoserin or tryptophan；The amino acid includes threonine, the valine that mass ratio is 2:1:1 in one of the embodiments,With tryptophan.The amino acid includes phosphatidylserine in one of the embodiments,；Institute in one of the embodiments,Stating amino acid includes threonine, valine, tryptophan and the phosphatidylserine that mass ratio is 2:1:1:1.
It is appreciated that the constituent of chitosan is the ingredient with chitosan；The shell is poly- in one of the embodiments,Sugared ingredient is selected from chitosan, organic selenium molecular chitosan derivative, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan alginic acidOne of salt or carboxymethyl chitosan are a variety of.The constituent of chitosan is or gathers including shell in one of the embodiments,Sugar, i.e., the described constituent of chitosan is chitosan or the constituent of chitosan includes chitosan；Further, an implementation whereinIn example, the N- deacetylation of the chitosan is greater than 80%.Further, the chitosan in one of the embodiments,N- deacetylation is greater than 85%.The constituent of chitosan is chitosan, organic selenium molecular chitosan in one of the embodiments,Derivative, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan alginates or carboxymethyl chitosan.Further, wherein oneIn a embodiment, the constituent of chitosan includes the chitosan and chitosan derivatives that mass ratio is 5:1~15:1；Wherein,The chitosan derivatives include organic selenium molecular chitosan derivative, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan algaeAt least one of hydrochlorate and carboxymethyl chitosan.The constituent of chitosan includes mass ratio in one of the embodiments,For the chitosan and chitosan derivatives of 8:1~12:1.The constituent of chitosan includes mass ratio in one of the embodiments,Example is the chitosan and chitosan derivatives of 8:1,9:1,10:1,11:1 or 12:1.Further, one embodiment whereinIn, the constituent of chitosan includes the chitosan and chitosan derivatives that mass ratio is 5:1~15:1；An implementation whereinIn example, the constituent of chitosan includes the chitosan and chitosan derivatives that mass ratio is 8:1~12:1.A reality whereinIt applies in example, the constituent of chitosan includes that the chitosan that mass ratio is 8:1,9:1,10:1,11:1 or 12:1 and chitosan spread outBiology.Further, in one of the embodiments, the chitosan derivatives include organic selenium molecular chitosan derivative,At least two in chitosan quaternary ammonium salt, chitosan hydrochloride, chitosan alginates and carboxymethyl chitosan.A reality whereinIt applies in example, the chitosan derivatives include the chitosan quaternary ammonium salt and chitosan hydrochloride that mass ratio is 1:1~1:4；ShellGlycan quaternary ammonium salt and chitosan hydrochloride all have water speed dissolved cation sterilization idiocratic, are the chemically modified modifications of chitosan and makeThe chitosan derivatives obtained.In one of the embodiments, the chitosan derivatives include 1:1:2 chitosan quaternary ammonium salt,Chitosan hydrochloride and chitosan alginates；Chitosan alginates, that is, chitosan alginate.Institute in one of the embodiments,Stating chitosan derivatives includes the chitosan quaternary ammonium salt and carboxymethyl chitosan that mass ratio is 1:2；Carboxymethyl chitosan is alsoChitosan derivatives prepared by the chemically modified modification of chitosan, property are stablized, and antibiotic property is strong.Further, wherein oneIn a embodiment, organic selenium molecular chitosan derivative is using chitosan and adjacent first seleno benzoic acid p-nitrophenyl phenolic ester, 2- benzeneBase -1,2- benzisoxa selenazoles -3- (2H) -one, -3 (2H) ketone of 2- (4 benzoic acid carbomethoxy) -1,2- benzisoxa selenazoles and/or seleniumIt reacts to obtain for oxalic acid, specific reaction ratio is designed and adjusted according to demand.In this way, multiple or even a variety of organic seleniumsMolecule passes through multiple NH on chitosan2Group is connected respectively on polymer chitosan, has certain anti peroxidation of lipidActivity and anti-tumor activity, either using in vitro or in vivo all with good antibacterial film-formation result, additionally it is possible to be applicable inIn tumor operation；Further, example, the film forming agent include 2%~12% in mass ratio in one of the embodiments,Organic selenium molecular chitosan derivative, 1%~12% glycerine, 0.1%~0.5% hyaluronic acid, 0.01%~0.05% basic fibroblast growth factor, 8%~20% sodium alginate and 1%~5% brown alga oligose, surplus isPure water, further, example, the film forming agent include 2%~12% chitosan in mass ratio in one of the embodiments,Ingredient, 1%~12% glycerine, 0.1%~0.5% hyaluronic acid, 0.01%~0.05% basic fibroblastGrowth factor, 8%~20% sodium alginate and 1%~5% brown alga oligose, surplus are pure water, the constituent of chitosanThe chitosan and organic selenium molecular chitosan derivative for being 8:1 including mass ratio, wherein organic selenium molecular chitosan derivativeUsing chitosan and adjacent first seleno benzoic acid p-nitrophenyl phenolic ester, 2- phenyl -1,2- benzisoxa selenazoles -3- (2H) -one, 2- (4-Methyl benzoate base) -1,2- benzisoxa selenazoles -3 (2H) ketone and seleno-diacetic acid react to obtain；Such design, including it is organicSelenium molecular chitosan derivative cooperates the film forming agent of brown alga oligose, has preferable facilitation for immune system and resistsOxidation effectiveness helps to inhibit tumor cell proliferation.
The cleaning agent and the film forming agent have different constituent of chitosan in one of the embodiments,.FurtherThe constituent of chitosan on ground, the cleaning agent is or including chitosan, chitosan quaternary ammonium salt, chitosan hydrochloride, chitosanAt least one of alginates and carboxymethyl chitosan.Further, the constituent of chitosan of the film forming agent be or includingAt least one of chitosan and organic selenium molecular chitosan derivative.The institute of the cleaning agent in one of the embodiments,Stating constituent of chitosan is chitosan；The constituent of chitosan of the film forming agent includes the chitosan season that mass ratio is 1:1:2Ammonium salt, chitosan hydrochloride and chitosan alginates.The constituent of chitosan of the cleaning agent in one of the embodiments,For chitosan；The constituent of chitosan of the film forming agent includes the chitosan quaternary ammonium salt and chitosan salt that mass ratio is 1:1Hydrochlorate.Remaining embodiment and so on.As previously mentioned, cleaning agent and film forming agent are applied in the chitosan liquid of each embodiment of the applicationPositioning in material is different, and cleaning agent pays attention to cleaning effect, more demanding for mobility, and film forming agent is paid attention to form a filmIsolating and protecting effect, while wound being made to realize moistening effect, further also promote Wound healing under the premise of to Wound protection,In use, the cleaning agent of the chitosan liquid dressing is rinsed the surface of a wound, then sprays the chitosan liquidThe film forming agent of body dressing covers wound.Therefore give different proportions according to different product orientation to be arranged, be conducive toFlexible product line is realized under the premise of save the cost；In specific application, cleaning agent carry out cleaning bactericidal antiphlogistic withUnder the double action of film forming agent bactericidal antiphlogistic, the closed environment quickly formed by film forming agent can effectively retain woundDiffusate, reduces exudation and adhesion, and moist environment needed for providing quick healing of cut accelerates epidermal cell migration velocity, thornSwash cell Proliferation and promote release Porcine HGF, and inhibits the growth of bacterium in wound and promote fibroblastic lifeIt is long, thus promote cytothesis, it is further provided good zymetology debridement environment, to promote fibrin and necrotic tissueDissolution, and then realize acceleration wound healing.
In the embodiment that one is applied, there is the chitosan liquid dressing product of applicant the cleaning agent of subregion setting to holdChamber and film forming agent accommodating cavity are set, stores from same liquid storage bottle and sprays respectively respectively, use can also be supplemented respectively, either occupiedFamily is spare or medical use is all very convenient.That is, it is divided into mutual disconnected two accommodating cavities in a bottle, oneFor cleaning agent accommodating cavity, for storing cleaning agent, another is film forming agent accommodating cavity, for storing film forming agent.A reality whereinApply in example, the chitosan liquid dressing further includes liquid storage bottle, the liquid storage bottle be equipped with mutual disconnected cleaning agent accommodating cavity withFilm forming agent accommodating cavity, for the cleaning agent accommodating cavity for accommodating the cleaning agent, the film forming agent accommodating cavity is described for accommodatingFilm forming agent；Further, the liquid storage bottle is equipped with the cleaning agent for being connected to the cleaning agent accommodating cavity in one of the embodiments,Spray head and the film forming agent spray head for being connected to the film forming agent accommodating cavity；The cleaning agent spray head is used to spray by pressing mode describedThe cleaning agent of cleaning agent accommodating cavity, the film forming agent spray head are used to spray the film forming of the film forming agent accommodating cavity by pressing modeAgent；Further, the liquid storage bottle is equipped with cleaning agent accommodating cavity valve, film forming agent accommodating cavity valve in one of the embodiments,Door and pressing spray head, the pressing spray head are connected to the cleaning agent accommodating cavity, and institute by the cleaning agent accommodating cavity valveIt states pressing spray head and the film forming agent accommodating cavity is connected to by the film forming agent accommodating cavity valve；Such design simplifies spray head,While saving production cost, pass through the switch and film forming agent accommodating cavity valve of control cleaning agent accommodating cavity valve with can be convenientThe switch of door exports cleaning agent or film forming agent to control the pressing spray head, and can export cleaning agent and film forming simultaneously when necessaryThe mixed liquor of agent.Further, the cleaning agent accommodating cavity valve and the film forming agent accommodating cavity in one of the embodiments,Valve is wholely set to form a two-way valve, and the input duct of the pressing spray head and the two-way valve are rotatablely connected, described doubleIt is used to make the input duct that the cleaning agent accommodating cavity be connected when turning to the first predeterminated position to valve and turns to secondMake the input duct that the film forming agent accommodating cavity be connected when predeterminated position.Further, described in one of the embodiments,Cleaning agent accommodating cavity valve and the film forming agent accommodating cavity valve are wholely set to form a two-way valve, the pressing spray head intoLiquid pipe road and the two-way valve are rotatablely connected, and the two-way valve is for being connected the input duct when turning to a side positionThe cleaning agent accommodating cavity makes the input duct and the film forming agent accommodating cavity and the cleaning agent when turning to middle positionAccommodating cavity is in nonconducting state and makes the input duct that the film forming agent accommodating cavity be connected when turning to another side position.On the one hand such design is conducive to conversion using the cleaning agent and the film forming agent, is on the other hand conducive to when storedThe isolation degree of the cleaning agent Yu the film forming agent is kept, to improve the use validity period of product.Further, whereinIn one embodiment, the liquid storage bottle is in the cleaning agent accommodating cavity or its wall portion and the film forming agent accommodating cavity or its wall partNot She You injection hole and its closure portion, for the closure portion for closing the injection hole, the injection hole is described clear for injectingLotion or the film forming agent, i.e., the injection hole of the described cleaning agent accommodating cavity is for injecting the cleaning agent, the film forming agent accommodatingThe injection hole of chamber is for injecting the film forming agent；Such design can reuse the liquid storage bottle and cleaning agent thereinAccommodating cavity and film forming agent accommodating cavity are particularly suitable for the biggish occasion of the dosages such as hospital and use.
In order to promote the blood coagulation haemostatic effect of film forming agent, further, the film forming agent spray in one of the embodiments,Head or the pressing spray head have multiple spray orifices, in one of the embodiments, the film forming agent spray head or the pressing spray headWith multiple spray orifices and the multiple spray orifice is distributed in more than center and in a manner of periphery is few；Further, an implementation whereinIn example, the multiple spray orifice forms multiple annular concentrics, and the interannular of each annular concentric of central area is away from less than neighboring areaEach annular concentric interannular away from；Further, in one of the embodiments, from the center to periphery, the ring of each annular concentricSpacing forms ascending series, also referred to as the first ascending series.Further, in one of the embodiments, from the center to weekSide, the interannular of each annular concentric is away from formation equal difference ascending series, also referred to as the first equal difference ascending series.Further, at itIn middle one embodiment, the spacing of the adjacent orifices of each annular concentric of central area is less than each annular concentric of neighboring areaThe spacing of adjacent orifices.Further, in one of the embodiments, from the center to periphery, the adjacent orifices of each annular concentricSpacing formed ascending series, also referred to as the second ascending series.Further, in one of the embodiments, from the center toThe spacing on periphery, the adjacent orifices of each annular concentric forms equal difference ascending series, also referred to as the second equal difference ascending series.FirstEqual difference ascending series and the difference of the second equal difference ascending series can identical or different settings.Such design, forms centerThe few spray orifice distribution in more peripheries, so that the film forming agent that central area sprays is more, and then can artificially control film forming agentMain ejection distribution at key position, thereby realizes film forming agent and mainly concentrates and be sprayed at serious wound, is thus promotedBlood coagulation haemostatic effect of the film forming agent at wound key position.And/or in order to preferably promote the blood coagulation of film forming agent hemostasis effectFruit, further, the aperture of the multiple spray orifice is distributed in such a way that center is big and periphery is small in one of the embodiments,；Further, in one of the embodiments, from the center to periphery, the aperture of each spray orifice forms ascending series, can also claimFor third ascending series.Further, in one of the embodiments, from the center to periphery, the aperture of each spray orifice is formedEqual difference ascending series, also referred to as third equal difference ascending series.Such design forms the small spray orifice in the big periphery in center pointCloth, so that the film forming agent that central area sprays is more, and then can artificially control the main ejection distribution of film forming agent, thisSample is achieved that film forming agent is mainly concentrated and is sprayed at serious wound, thus improves blood coagulation of the film forming agent at wound key positionHaemostatic effect.
In order to promote the antibacterial and anti-inflammatory effects of the chitosan liquid dressing, further, in one of the embodiments,The chitosan liquid dressing further includes the suspension of liquid, and the liquid storage bottle is additionally provided with suspension accommodating cavity, the suspensionAccommodating cavity is for accommodating the suspension, the suspension accommodating cavity and the cleaning agent accommodating cavity and the film forming agent accommodating cavityIt is not mutually connected to setting, i.e., the described liquid storage bottle is equipped with mutual disconnected suspension accommodating cavity, cleaning agent accommodating cavity and film forming agent and accommodatesChamber.Further, the liquid storage bottle is equipped with the suspension spray for being connected to the suspension accommodating cavity in one of the embodiments,Head, the suspension spray head are used to spray the suspension of the suspension accommodating cavity by pressing mode.Further, whereinIn one embodiment, the liquid storage bottle is equipped with suspension accommodating cavity valve, cleaning agent accommodating cavity valve, film forming agent accommodating cavity valveWith pressing spray head, the pressing spray head is connected to the cleaning agent accommodating cavity, the pressing by the cleaning agent accommodating cavity valveSpray head is connected to the film forming agent accommodating cavity by the film forming agent accommodating cavity valve, and the pressing spray head passes through the suspensionAgent accommodating cavity valve is connected to the suspension accommodating cavity.Further, the suspension accommodating cavity in one of the embodiments,Valve, the cleaning agent accommodating cavity valve and the film forming agent accommodating cavity valve are wholely set to form a two-way valve, described to pressThe input duct and the two-way valve for pressing spray head are rotatablely connected, and the pressing spray head is for passing through the input duct and instituteState two-way valve select the gating suspension accommodating cavity valve, the cleaning agent accommodating cavity valve and the film forming agent accommodating cavity orPerson and the suspension accommodating cavity, the film forming agent accommodating cavity and the cleaning agent accommodating cavity are in nonconducting state.It is suchOn the one hand design is conducive to conversion using the suspension, the cleaning agent and the film forming agent, on the other hand has when storedConducive to the isolation degree of the cleaning agent and the film forming agent is kept, to improve the use validity period of product.Further, existIn one embodiment, the liquid storage bottle is also equipped with injection hole and its closure portion in the suspension accommodating cavity or its wall portion,The closure portion is for closing the injection hole, and the injection hole of the suspension accommodating cavity is for injecting the suspension；In this wayDesign, the liquid storage bottle and suspension accommodating cavity therein can be reused, be particularly suitable for the biggish field of dosages such as hospitalIt closes and uses.The example of one application is when in use, first to carry out cleaning wound using cleaning agent, then sprayed and created with suspensionMouthful, then wound is closed with film forming agent, thus appropriate suspension is closed in wound.The example of another application is to useWhen, two-way valve is first rotated, makes it from equal with the suspension accommodating cavity, the film forming agent accommodating cavity and the cleaning agent accommodating cavityThe connection cleaning agent accommodating cavity is gone in nonconducting state, presses the pressing spray head then to spray cleaning agent cleaning woundMouthful, then two-way valve is rotated, so that it is gone to the connection suspension accommodating cavity, it is appropriate mixed to spray then to press the pressing spray headIn suspension to wound, two-way valve is finally rotated, it is made to go to the connection film forming agent accommodating cavity, presses the pressing spray head to sprayWound is closed on appropriate film forming agent to wound out.
Further, it is that 1%~10% sustained release disappears that the suspension, which has mass ratio, in one of the embodiments,Scorching body；Further, the suspension is that the sustained release for being 1%~10% with mass ratio disappears in one of the embodiments,The physiological saline of scorching body；Remaining embodiment and so on.Further, the suspension is tool in one of the embodiments,There is the Benza that the mass ratio of sustained release anti-inflammatory body is 0.01%~0.05%.Further, one embodiment whereinIn, the suspension is the ethanol solution that the volume ratio with sustained release anti-inflammatory body is 70%~75%.Further, wherein oneIn a embodiment, the suspension is cleaning agent described in any of the above-described embodiment with sustained release anti-inflammatory body.Further, at itIn middle one embodiment, the suspension is film forming agent described in any of the above-described embodiment with sustained release anti-inflammatory body, or will be upperIt states the constituent of chitosan in film forming agent described in any embodiment and replaces with the sustained release anti-inflammatory body.Further, each to implementIn example, the sustained release anti-inflammatory body is the anti-inflammatory particle with wrapping layer.Such design, it is micro- using the anti-inflammatory with wrapping layerThe sustained release anti-inflammatory body of grain enables above-mentioned chitosan liquid dressing to have long-acting sustained release antiinflammation in use, furtherSlow-release time can be controlled by the ingehious design to wrapping layer, to play longer sustained release antiinflammation, have and passThe unrivaled anti-inflammatory effects of system technology.Further, in one of the embodiments, each sustained release anti-inflammatory body be divided into it is N number ofSustained release anti-inflammatory body group, the different setting of the thickness of N number of wrapping layer for being sustained anti-inflammatory body group and formation ascending series, the also referred to as the 4thAscending series；N is the natural number greatly with 1；Further, adjacent in the 4th ascending series in one of the embodiments,The thickness difference of two sustained release anti-inflammatory body groups is the 1/N of the estimated cure time of wound；Further, one embodiment whereinIn, the thickness of the wrapping layer of N number of sustained release anti-inflammatory body group is different to be arranged and forms equal difference ascending series, and also referred to as the 4th equal difference is passedIncrease ordered series of numbers.Such design, be sustained anti-inflammatory body in anti-inflammatory particle release process come across for a long time the chitosan liquid applyThe degradation absorption process of material or even reach the chitosan liquid dressing degradation absorption process it is final, thus play compared withLong sustained release antiinflammation, on the one hand advantageously forms releasing the time for difference, is on the other hand conducive to control anti-inflammatory particleStart to release the time, above-mentioned chitosan liquid dressing is set during being degraded and absorbed according to the ingenious of wrapping layerMeter to play longer sustained release antiinflammation, and then can be controlled in chitosan liquid dressing to control slow-release timeIt is absorbed in overall process or part stage and is sustained anti-inflammatory particle on demand, therefore there is the unrivaled anti-inflammatory effect of traditional technologyFruit.Each sustained release anti-inflammatory body is divided at least two sustained release anti-inflammatory body groups, and each sustained release anti-inflammatory body group in one of the embodiments,Wrapping layer the different setting of thickness.
The wrapping layer includes chitosan or alginate fibre in one of the embodiments,.In one of the embodiments,The wrapping layer includes chitosan and alginate fibre.Alginate fibre is one kind of staple fibre, refers to some brown algaes from oceanThe alginic acid extracted in class plant is fiber made from raw material；Alginate fibre is using extracted substance in natural seaweedSpinning is process, and since raw material comes from natural seaweed, alginate fibre has good biocompatibility and degradable suctionProperty received and other effects.Alginate fibre is obtained for example, being added to grind finely ground marine algae powder and reeled off raw silk from cocoons in spinning solution.ThisA little marine algae powders mostly come from brown algae, red algae, green alga and blue algae.Alginate fibre also has absorbability, it can be absorbed 20The liquid of times oneself volume, it is possible to which reducing wound, microorganism evil is raw and its issuable peculiar smell of institute, therefore especiallySuitable for hemostasis and as body absorption materials'use.The wrapping layer includes mass ratio in one of the embodiments,For the chitosan and alginate fibre of 1:1~1:4.Further, the wrapping layer includes mass ratio in one of the embodiments,Example is the chitosan and alginate fibre of 1:1,1:2,1:3 or 1:4.In this way, using chitosan as the wrapping layer part or entirelyPortion can use the characteristics of chitosan itself inhibits bacterial activity, also function to a part of antibacterial and anti-inflammation functions.
The anti-inflammatory particle includes anti-inflammation drugs in one of the embodiments, described in one of the embodiments, to disappearScorching particle includes sulfa drugs, i.e., the described anti-inflammation drugs include sulfa drugs；Sulfa drugs is broad spectrum antimicrobial agent, to leatherLan Shi positive bacteria and Gram-negative bacteria all have good antibacterial activity, and alternative inhibits micrococcus scarlatinae, pneumonia chainCoccus, haemophilus influenzae, escherichia coli, proteus mirabilis, chlamydia trachomatis, lymphogranuloma venereum ChlamydiaDeng and actinomyces, lung sac worm and slave block Pseudomonas etc..Sulfa drugs can penetrate into extensively body tissue and liquor pleurae, peritoneal fluid,In the various extracellular fluids such as synovial fluid, aqueous humor, saliva, sweat, urine, bile, cerebrospinal fluid can be entered through blood-brain barrier, also canInto milk and pass through placental barrier.And/or the anti-inflammatory particle includes quinolone drugs in one of the embodiments,The i.e. described anti-inflammation drugs include quinolone drugs；Quinolone drugs is also known as pyridonecarboxylic acids or pyridine Mek-Tol Unit, is manually to closeAt the basic structure of quinolone containing 4- antimicrobial.Quinolones, for target, interferes DNA with the DNA (DNA) of bacteriumGyrase further results in the irreversible lesion of DNA of bacteria, reaches antibacterial effect；Object has sterilization to make a variety of gram-negative bacteriasWith being widely used in disease of the genitourinary system, gastrointestinal disease and respiratory tract, the gram-negative bacterial infection of skin histology is controlledIt treats.Quinolone drugs is Enrofloxacin in one of the embodiments, have has a broad antifungal spectrum, sterilizing power are strong, effect is rapid,It is widely distributed in vivo and between other antibiotic without cross resistance the features such as, and/or, institute in one of the embodiments,Stating anti-inflammatory particle includes povidone iodine, i.e., the described anti-inflammation drugs include povidone iodine；Povidone iodine (Povidone iodine) isElemental iodine and polymer support loose compound made of combining, povidone play carrier and dissolution assistant effect.It is strong for wide spectrumPower disinfection sanitizer has stronger killing effect to virus, bacterium, fungi and mycotic spore.This product is small to skin irritation,Toxicity is low, persistent.Using safe and simple.It is substantially nonirritant to organizing, it is sterilized for skin and mucous membrane, such as operation consentCleaning, operative site and wound disinfection.And/or the anti-inflammatory particle includes phosphatidyl silk ammonia in one of the embodiments,Acid, i.e., the described anti-inflammation drugs include phosphatidylserine；Phosphatidylserine is also known as composite nerve acid.English namePhosphatidyLserine, abbreviation PS are extracted by crude soya bean oil expression residue.It is the active material of cell membrane, especially depositsIt is in brain cell.Its function mainly improves nerve cell function, adjusts the conduction of nerve impulse, promotes brain memory functionCan, blood-brain barrier can be run through since it is with very strong lipophilicity, after absorption and enters brain, play vascular smooth of releivingMyocyte increases the effect of brain blood supply, and application herein also helps activation injured surface factor.In each embodiment,It is lasting that the anti-inflammatory particle has under slow releasing function i.e. using particle made of the above-mentioned drug with antiinflammation, on the one handOn the other hand anti-inflammatory effects exist due to it in wrapping layer with particle, that is, solid form, shelf life of products, that is, chitosan liquidThe storage period of body dressing, is long, and service life is protected.Further, the anti-inflammatory is micro- in one of the embodiments,Grain be it is powdered, can more effectively be absorbed in this way by tissue fluid.It is appreciated that in each embodiment, the use of the anti-inflammatory particleAmount and proportion are arranged according to product design.Further, wrapping layer and anti-inflammatory particle therein in one of the embodiments,Mass ratio be 10:1~120:1.Further, the anti-inflammatory particle includes mass ratio in one of the embodiments,For the sulfa drugs and phosphatidylserine of 9:1~16:1.Further, the anti-inflammatory is micro- in one of the embodiments,Grain includes the quinolone drugs and phosphatidylserine that mass ratio is 9:1~16:1.Further, an implementation whereinIn example, the anti-inflammatory particle includes sulfa drugs, povidone iodine and the phosphatidylserine that mass ratio is 10:2:1.Into oneStep ground, the anti-inflammatory particle includes the sulfa drugs and Du-6859a that mass ratio is 1:1 in one of the embodiments,Object.Further, in one of the embodiments, the anti-inflammatory particle include mass ratio be 12:10:2:1 sulfonamidesObject, quinolone drugs, povidone iodine and phosphatidylserine.It is appreciated that anti-inflammatory particle can also include other anti-inflammatory drugsObject, the application have no additional limitation to this.
It provides some embodiments again below and carries out Experimental Comparison.