A kind of ankle prosthesis shin bone sidepiece partTechnical field
The present invention relates to the field of medical instrument technology more particularly to a kind of ankle prosthesis shin bone sidepiece parts.
Background technique
Artificial joint prosthesis is mainly used in the pain of ankle-joint caused by various wounds, autoimmune disease, degenerative diseaseBitterly, the patient that deformity, function are lost.For ankle-joint, currently used ankle fusion can be such that patient loses almostThe motor function of whole ankle-joints, ankle-joint replace the motor function that can retain most of ankle-joint, and thoroughly solve patient'sPain and lopsided problem.Home and abroad patent consulting is not the results show that the design of existing full ankle prosthesis is complete bionical symbolThe real ankle-joint anatomical structure of human body is closed, biomethanics also changes, and does not meet the characteristics of motion and feature under physiological conditions.Therefore, prosthese revision rate, prosthetic loosening rate, unstability are high.More than half since the first generation manually full ankle-joint applicationCentury, the stability and persistence of joint prosthesis are always to limit the main factor of its development.And patient is for quality of lifeIt is required that increasingly increasing, so requiring also to increase therewith for ankle joint function.But current ankle prosthesis cannot still provide goodIn the case where stability well, persistence and good function, the design and invention for carrying out novel artificial ankle prosthesis can be mentionedFor patient's preferably therapeutic modality, mitigate patient suffering, lowers patient's deformity, disabled probability, greatly improve the life of patientQuality.
Application No. is the Chinese patents of CN201710754997.3 to disclose a kind of anatomical form fixed-bearing ankle-joint before thisProsthese, there are full ankle prosthesis revision rate height, loosening rate are high and stable for disclosed anatomical form fixed-bearing ankle prosthesisThe low defect of property, now improves its tibial side component, provides a kind of new ankle prosthesis shin bone sidepiece part.
Shin bone or other bones integrally remove displacement class operation the fusion growth of prosthese and other positions is generally used it is generalLogical porous structure can satisfy requirement, but for the operation of femoral surface displacement etc, for melting for postoperative prosthese and shin boneThe long requirement of symphysis is higher, higher to the requirement of femoral surface replacement prosthesis, and the femoral surface replacement prosthesis for needing one kind novel canPreferably and shin bone fusion growth is to mitigate patient suffering, lowers patient's deformity, disabled probability, greatly improves the life of patientQuality.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of ankle prosthesis shin bone sidepiece part, to solve in the prior art?.
The present invention solves above-mentioned technical problem by following technological means:
A kind of ankle prosthesis shin bone sidepiece part, including tibial side component and fixed-bearing, the shape of the tibial side componentShape and individual patients are matched by damage femoral surface anatomical shape, and the top of the tibial side component is equipped with upper bearing surface, institute of instituteThe bottom for stating tibial side component is provided with lower chimeric surface, and the pin of four protrusions is fixed on the quadrangle of the upper bearing surfaceIt is fixedly connected with the distal tibial after osteotomy, tabernacle is provided in the middle part of the tibial side component and closes screw, for reinforcing tibial sideComponent is fixedly connected with shin bone, and fixed-bearing is equipped on the lower chimeric surface, and the top of the fixed-bearing is equipped with upperJoint face, the upper joint face fit with lower chimeric surface, and the bottom of the fixed-bearing is provided with lower slider face, the upper branchThe surface of bearing surface is porous structure, has biological function, the layout and shape of the porous structure on the upper bearing surface and troublePerson is accordingly matched by the trabecular bone structure of damage femoral surface concave and convex part.
The present invention carries out finite element analysis by the geometry to prosthese and experiment of machanics demonstrates the initial steady of prostheseQualitative differences, and carried out in vitro by the exemplar to 3D printing individuation shin bone trabecular bone structure and the exemplar of common porous structureWith intracorporal biocompatibility experiment, it was demonstrated that the stability again of prosthese.
Experiment in vitro of the invention be using adherency of the mescenchymal stem cell on the exemplar of different porous structures, proliferation,The biological behaviours such as differentiation, apoptosis, and observe, record the expression of its skeletonization coherent signal, to judge different porous structuresBio-compatible implementations；Experiment in vivo be by manufacture goat shin bone neuropathy model, take the prosthese of different porous structures intoLine replacement observes the difference of Bone Ingrowth by Microct inspection and hard tissue slicing, to judge the biology of different porous structuresCompatible implementations.The results show that the shin bone of the porous structure of individuation shin bone trabecular bone structure-prosthese interface Bone Ingrowth hasAdvantage.
Further, the upper bearing surface, lower chimeric surface, upper joint face, lower slider face are arc, meet model of human ankleStructure.
Further, it is hollow structure that the tabernacle, which closes screw, and is matched with the screw hole in tibial side component, the tabernacleScrew is closed to be mounted on inside screw hole.
Further, the tibial side component is made of titanium alloy.
Beneficial effects of the present invention:
The present invention can be improved the stability of prosthese, realizes the biomechanical function for quickly repairing, rebuilding ankle-joint, mitigatesPatient suffering reduces patient's deformity, disabled probability.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of ankle prosthesis shin bone sidepiece part of the present invention；
Fig. 2 is a kind of structural schematic diagram of the tibial side component of ankle prosthesis shin bone sidepiece part of the present invention；
Fig. 3 is a kind of structural representation of the lower chimeric surface of the tibial side component of ankle prosthesis shin bone sidepiece part of the present inventionFigure；
Fig. 4 is a kind of top view of the tibial side component of ankle prosthesis shin bone sidepiece part of the present invention；
Fig. 5 is a kind of structural schematic diagram of the fixed-bearing of ankle prosthesis shin bone sidepiece part of the present invention；
Fig. 6 is the structural schematic diagram that a kind of tabernacle of ankle prosthesis shin bone sidepiece part of the present invention closes screw；
Fig. 7 is the osteoblast number statistical chart of experiment in vitro of the invention；
Fig. 8 is alkaline phosphatase (ALP) content statistical chart of experiment in vitro of the invention；
Wherein, tibial side component 1, upper bearing surface 11, lower chimeric surface 12, screw hole 13, porous structure 14, fixed-bearing 2,Upper joint face 21, lower slider face 22, pin 3, tabernacle close screw 4, entity structure group A, bone trabecula porous structure group B, common porousStructure group C.
Specific embodiment
Below with reference to the drawings and specific embodiments, the present invention is described in detail:
As shown in figs 1 to 6, a kind of ankle prosthesis shin bone sidepiece part, including tibial side component 1 and fixed-bearing 2, instituteThe shape and individual patients for stating tibial side component 1 are matched by damage femoral surface anatomical shape, the top of the tibial side component 1Equipped with upper bearing surface 11, the bottom of the tibial side component 1 be provided with lower chimeric surface 12, on the quadrangle of the upper bearing surface 11The pin 3 for being fixed with four protrusions is fixedly connected with the distal tibial after osteotomy, the middle part setting of the tibial side component 1There is tabernacle to close screw 4, for reinforcing being fixedly connected for tibial side component 1 and shin bone, fixed lining is installed on the lower chimeric surface 12Pad 2, the upper joint face 21 that the top of the fixed-bearing 2 is equipped with, the upper joint face 21 fits with lower chimeric surface 12, describedThe bottom of fixed-bearing 2 is provided with lower slider face 22, and the surface of the upper bearing surface 11 is porous structure 14, has biology functionCan, the layout and shape of the porous structure 14 on the upper bearing surface 11 and patient are by the bone trabecula of damage femoral surface concave and convex partStructure accordingly matches, and grows convenient for tibial side component 1 and osteotomy surface rapid fusion.
Upper bearing surface 11, lower chimeric surface 12, upper joint face 21, lower slider face 22 are arc, meet model of human ankle knotStructure.
Finite element analysis is carried out by the geometry to prosthese in the present embodiment and experiment of machanics demonstrates the first of prostheseBeginning stability difference, and carried out by the exemplar to 3D printing individuation shin bone trabecular bone structure and the exemplar of common porous structureThe biocompatibility experiment of in vitro and in vivo, it was demonstrated that the stability again of prosthese.
Experiment in vitro is adherency, the increasing using mescenchymal stem cell on the exemplar of different porous structures in the present embodimentIt grows, break up, the biological behaviours such as apoptosis, and observing, record the expression of its skeletonization coherent signal, to judge different porous structuresBio-compatible implementations；Experiment in vivo is the shin bone neuropathy model by manufacturing goat, takes the prosthese of different porous structuresIt is replaced, the difference of Bone Ingrowth is observed by Microct inspection and hard tissue slicing, to judge the life of different porous structuresThe compatible implementations of object.The results show that the shin bone of the porous structure of individuation shin bone trabecular bone structure-prosthese interface Bone Ingrowth hasIt is advantageous.
The stability again of bone and prosthese relies primarily on growing into for bone, and prosthese and bone fusion are integrated, and osteoblast is intoThe main cell of bone, alkaline phosphatase (ALP) etc. facilitate the relevant factor pair skeletonization adjustment effect of bone；Osteoblast is more, promoteesFactor content into skeletonization is higher, and skeletonization is more obvious.
It is set in vitro experiment referring to Fig. 7 to measure the prosthese of different porous structures and the bio-compatible implementations of shin boneDetermine three kinds of prostheses and done comparative experiments, is respectively as follows: entity structure group A, bone trabecula porous structure group B, common porous structure group C,Prosthese in entity structure group A does not open up porous structure, the vacation in bone trabecula porous structure group B on the surface of upper bearing surface 11Body offers the porous structure to match with shin bone trabecular bone structure, common porous structure group C on the surface of upper bearing surface 11In prosthese the porous structure of general structure is offered on the surface of upper bearing surface 11, in figure 5 it can be seen that bone trabecula porous structureOsteoclast number in group B is obviously than other more than two groups.
It is the alkaline phosphatase of the experiment in vitro of personalized femoral surface replacement prosthesis in the present embodiment referring to Fig. 8, Fig. 8(ALP) content statistical chart, in figure 5 it can be seen that the skeletonization correlation factor ALP content in bone trabecula porous structure group B is obviously than other twoGroup is high.
Therefore, referring to Fig. 7 and Fig. 8 it can be proved that shin bone-prosthese circle of the porous structure of individuation shin bone trabecular bone structureThe Bone Ingrowth in face has advantage, and the stability again of bone and prosthese is more preferable.
The above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to preferred embodiment to this hairIt is bright to be described in detail, those skilled in the art should understand that, it can modify to technical solution of the present inventionOr equivalent replacement should all cover without departing from the objective and range of technical solution of the present invention in claim of the inventionIn range.Technology not described in detail in the present invention, shape, construction portion are well-known technique.