CN1093004A - Long-acting broad-spectrum antibacterial medical suture - Google Patents
Long-acting broad-spectrum antibacterial medical sutureDownload PDFInfo
- Publication number
- CN1093004A CN1093004ACN 93103280CN93103280ACN1093004ACN 1093004 ACN1093004 ACN 1093004ACN 93103280CN93103280CN 93103280CN 93103280 ACN93103280 ACN 93103280ACN 1093004 ACN1093004 ACN 1093004A
- Authority
- CN
- China
- Prior art keywords
- line
- silver
- long
- medical suture
- ultra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000844anti-bacterial effectEffects0.000titleclaimsabstractdescription23
- 229910052709silverInorganic materials0.000claimsabstractdescription20
- 239000004332silverSubstances0.000claimsabstractdescription20
- 239000000835fiberSubstances0.000claimsabstractdescription14
- 239000000126substanceSubstances0.000claimsabstractdescription5
- 229920000742CottonPolymers0.000claimsabstractdescription3
- 238000002156mixingMethods0.000claimsabstractdescription3
- BQCADISMDOOEFD-UHFFFAOYSA-NSilverChemical compound[Ag]BQCADISMDOOEFD-UHFFFAOYSA-N0.000claimsdescription18
- 239000000243solutionSubstances0.000claimsdescription11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-NAscorbic acidChemical compoundOC[C@H](O)[C@H]1OC(=O)C(O)=C1OCIWBSHSKHKDKBQ-JLAZNSOCSA-N0.000claimsdescription6
- 238000009423ventilationMethods0.000claimsdescription5
- 101710134784AgnoproteinProteins0.000claimsdescription3
- 229960005070ascorbic acidDrugs0.000claimsdescription3
- 235000010323ascorbic acidNutrition0.000claimsdescription3
- 239000011668ascorbic acidSubstances0.000claimsdescription3
- 238000000034methodMethods0.000claimsdescription3
- 238000001556precipitationMethods0.000claimsdescription3
- XLYOFNOQVPJJNP-UHFFFAOYSA-NwaterSubstancesOXLYOFNOQVPJJNP-UHFFFAOYSA-N0.000claimsdescription3
- 239000007864aqueous solutionSubstances0.000claimsdescription2
- 239000003638chemical reducing agentSubstances0.000claimsdescription2
- 239000013078crystalSubstances0.000claimsdescription2
- 238000002360preparation methodMethods0.000claimsdescription2
- 238000010438heat treatmentMethods0.000claims1
- 238000004519manufacturing processMethods0.000claims1
- 241000191967Staphylococcus aureusSpecies0.000abstractdescription5
- 241000222122Candida albicansSpecies0.000abstractdescription4
- 206010059866Drug resistanceDiseases0.000abstractdescription4
- 241000588653NeisseriaSpecies0.000abstractdescription4
- 241000589517Pseudomonas aeruginosaSpecies0.000abstractdescription4
- 241000191963Staphylococcus epidermidisSpecies0.000abstractdescription4
- 241000700605VirusesSpecies0.000abstractdescription4
- 229940095731candida albicansDrugs0.000abstractdescription4
- 241000193830Bacillus <bacterium>Species0.000abstractdescription3
- 210000001072colonAnatomy0.000abstractdescription3
- 230000000694effectsEffects0.000abstractdescription3
- 230000002147killing effectEffects0.000abstract1
- 231100000252nontoxicToxicity0.000abstract1
- 230000003000nontoxic effectEffects0.000abstract1
- 230000001954sterilising effectEffects0.000description7
- 238000004659sterilization and disinfectionMethods0.000description7
- 230000003115biocidal effectEffects0.000description6
- QGZKDVFQNNGYKY-UHFFFAOYSA-NAmmoniaChemical compoundNQGZKDVFQNNGYKY-UHFFFAOYSA-N0.000description2
- FAPWRFPIFSIZLT-UHFFFAOYSA-MSodium chlorideChemical compound[Na+].[Cl-]FAPWRFPIFSIZLT-UHFFFAOYSA-M0.000description2
- 206010052428WoundDiseases0.000description2
- 208000027418Wounds and injuryDiseases0.000description2
- 230000009286beneficial effectEffects0.000description2
- 230000008901benefitEffects0.000description2
- 230000007246mechanismEffects0.000description2
- 244000052769pathogenSpecies0.000description2
- 230000001717pathogenic effectEffects0.000description2
- 230000008569processEffects0.000description2
- 238000003756stirringMethods0.000description2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N6-methoxy-1,2,3,4-tetrahydroquinolineChemical compoundN1CCCC2=CC(OC)=CC=C21FRXSZNDVFUDTIR-UHFFFAOYSA-N0.000description1
- 244000063299Bacillus subtilisSpecies0.000description1
- 235000014469Bacillus subtilisNutrition0.000description1
- 241000894006BacteriaSpecies0.000description1
- VEXZGXHMUGYJMC-UHFFFAOYSA-MChloride anionChemical compound[Cl-]VEXZGXHMUGYJMC-UHFFFAOYSA-M0.000description1
- 102000004190EnzymesHuman genes0.000description1
- 108090000790EnzymesProteins0.000description1
- 241000588724Escherichia coliSpecies0.000description1
- 241000606768Haemophilus influenzaeSpecies0.000description1
- 241000192035Peptostreptococcus anaerobiusSpecies0.000description1
- 241001354013Salmonella enterica subsp. enterica serovar EnteritidisSpecies0.000description1
- 241000293871Salmonella enterica subsp. enterica serovar TyphiSpecies0.000description1
- 229910021529ammoniaInorganic materials0.000description1
- 230000000845anti-microbial effectEffects0.000description1
- 230000002421anti-septic effectEffects0.000description1
- 229940088710antibiotic agentDrugs0.000description1
- 230000000680avirulenceEffects0.000description1
- 244000052616bacterial pathogenSpecies0.000description1
- 230000008859changeEffects0.000description1
- 238000006243chemical reactionMethods0.000description1
- 238000005336crackingMethods0.000description1
- 230000000249desinfective effectEffects0.000description1
- 230000006866deteriorationEffects0.000description1
- 208000001848dysenteryDiseases0.000description1
- 239000008187granular materialSubstances0.000description1
- 239000000463materialSubstances0.000description1
- 238000002791soakingMethods0.000description1
- 239000011780sodium chlorideSubstances0.000description1
- 238000003860storageMethods0.000description1
- 238000005406washingMethods0.000description1
- 238000005303weighingMethods0.000description1
- 230000029663wound healingEffects0.000description1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
The present invention relates to a kind of long-acting broad-spectrum antibacterial medical suture.
Silver has great sterilization ability, and the present invention is the elemental silver that makes the ultra-fine grain of energy firm attachment on line fiber by the processing of chemistry and physics.The surface area of the ultra-fine grain silver of 1 gram can reach x00-x000m2Thereby, reached with the silver of minute quantity and can obtain very big silver surface with sterilization ability.Because silver is ultra-fine granular attitude, so also strengthened silver-colored original sterilization ability.The present invention belongs to the antimicrobial treatment of line fiber and application thereof.In operation stitching, might catch multiple morbific pathogen and cause the suture place to infect with virus, influence wound healing, to this, long-acting broad-spectrum antibacterial medical suture has good practical values.
The sterilization ability of silver ancient known it, also the antibacterial tests of multiple pathogen is confirmed in studying for the present invention.Its antibiotic mechanism is as follows:
Ag=Ag+(when Ag is ultra-fine granular attitude, surface area increases+e, then is beneficial to the dextrad reaction.）
Ag+Can (SH) combine, make some enzyme loss of activity, and reach sterilization functions with the sulfydryl of pheron in the thalline as necessary base.
Because the antibiotic mechanism of above-mentioned Ag makes the long-acting broad-spectrum antibacterial line with ultra-fine grain elemental silver of the present invention have stronger antibacterial ability.Staphylococcus aureus (blue or green quick with drug resistance), bacillus pyocyaneus, colon bacillus, Candida albicans, Staphylococcus albus, gonococcus there is tangible antibiotic advantage with relevant virus.
The objective of the invention is the firm elemental silver that adheres to ultra-fine on line fiber, make this line have the long-acting broad-spectrum antibacterial ability by chemistry and physical treatment.
Processing technology of the present invention:
A, preparation do not contain any precipitation and muddy silver-containing solution.
Especially on line inevitably with chloride, as NaCl etc., when soaking line, do not produce coarse grained argentiferous granule with silver-containing solution in order to make, therefore Ag-containing solution prescription of the present invention is with crystal AgNO3Be dissolved in ammoniated aqueous solution and obtain Ag(NH3)+2True solution, even run into Cl-The time can not produce coarse grain argentiferous precipitation yet, and reach the purpose that can soak into line equably.
B, add again in the Ag-containing solution after an amount of Reducing agent ascorbic acid stirs evenly above-mentioned making, immediately with line at room temperature, have under the ventilation condition and soak-push-soak-push, make it evenly moistening.
C, with above-mentioned gained line, under ventilation condition, heat-treat, present yellowish-brown to line, on this moment line fiber with ultra-fine grain elemental silver.
D, with the above-mentioned line that makes, put into water through extruding, soak, remove water-soluble substances residual in the line, oven dry more promptly gets the present invention's long-acting broad-spectrum antibacterial medical suture.
Compare prior art, the present invention has following advantage:
1, has broad-spectrum antiseptic ability (seeing attached list 1), existing suture only adopts the sterilization means to make does not have pathogenic bacterium on the line, but do not have an antibacterial ability, and the present invention there is tangible antibacterial action to antibacterials such as staphylococcus aureus (blue or green quick with drug resistance), bacillus pyocyaneus, colon bacillus, Candida albicans, Staphylococcus albus, gonococcuss with relevant virus.As antibacterial medical suture, have the suture that prevents operative incision and wound and infect.
2, has the long acting antibiotic ability, the present invention is through 100 washings, antibacterial ability does not have obviously and weakens, and otch and wound are seamed to take out stitches generally needs 5-10 days, general antibiotic to be difficult to keep long antibacterial effect, and the present invention's antibacterial ability long-time in nothing obviously weaken.
3, the present invention is to human body avirulence, non-stimulated, the irritated effect of nothing.
4, because of the present invention be the elemental silver of ultra-fine grain attached on the line fiber, disinfecting action that therefore can high temperature high voltage resistant is beneficial to the sterilization process of final products.
5, because of the present invention be the elemental silver of ultra-fine grain attached on the line fiber, even long-time storage also undergoes no deterioration, especially can also anti-solar exposure and irradiation under ultraviolet ray, can not produce cracking, qualitative change.
6, technological process is simple, investment is little, cost is low, and it is fast to go into operation.
The invention will be further described by following example:
Take by weighing 5-20 gram AgNO3(C.P.) be dissolved in 500ml water and the 50-100ml ammonia, be diluted to 1000ml after the dissolving, shake up, the ascorbic acid solution that adds 3-10g again in this solution stirs evenly.With line at room temperature, under ventilation condition, soak-push-soak-push-heat treatment-embathe-dry, promptly get the present invention's long-acting broad-spectrum antibacterial medical suture.The material of line can be silk, cotton, fiber crops, hair, chemical fibre, blending etc.
Subordinate list 1:
The antibiotic strain of long-acting broad-spectrum antibacterial medical suture:
Staphylococcus aureus (blue or green quick) gonococcus
Staphylococcus aureus (drug resistance) bacillus subtilis
The bacillus pyocyaneus dysentery bacterium
The escherichia coli Bacillus typhi
The Staphylococcus albus bacillus enteritidis
The Candida albicans hemophilus influenzae
Streptococcus anaerobius
Claims (2)
1, a kind of long-acting broad-spectrum antibacterial medical suture is characterized in that line (silk, cotton, fiber crops, hair, chemical fibre, blending etc.) fiber surface is attached with ultra-fine grain elemental silver.
2, the manufacture method by claim 1 described long-acting broad-spectrum antibacterial medical suture is characterised in that:
A, preparation do not contain any precipitation or muddy silver-containing solution.The silver solution formula is with crystal AgNO3Be dissolved in ammoniated aqueous solution, and obtain containing Ag(NH3)+2True solution,
B, in the above-mentioned Ag-containing solution that makes, add an amount of Reducing agent ascorbic acid again, with line at room temperature, have under the ventilation condition and soak-push-soak-push, make it evenly moistening,
C, with above-mentioned gained line, under ventilation condition heat treatment, the online yellowish-brown that occurs, this moment line firm with ultra-fine grain elemental silver,
D, with the line that makes, put into water through pushing-soak, remove water-soluble substances residual on the line, oven dry promptly gets the present invention's long-acting broad-spectrum antibacterial medical suture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103280CN1093004A (en) | 1993-03-19 | 1993-03-19 | Long-acting broad-spectrum antibacterial medical suture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93103280CN1093004A (en) | 1993-03-19 | 1993-03-19 | Long-acting broad-spectrum antibacterial medical suture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1093004Atrue CN1093004A (en) | 1994-10-05 |
Family
ID=4984567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93103280PendingCN1093004A (en) | 1993-03-19 | 1993-03-19 | Long-acting broad-spectrum antibacterial medical suture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1093004A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006021155A1 (en)* | 2004-08-25 | 2006-03-02 | Xiaoyan Ren | Nano-silver thread |
| CN1294995C (en)* | 1999-12-15 | 2007-01-17 | C·R·巴德公司 | Polymer compositions containing colloids of silver salts |
| WO2007089864A3 (en)* | 2006-01-30 | 2007-12-13 | Angiotech Pharm Inc | Sutures and fibrosing agents |
| CN101585088B (en)* | 2008-05-21 | 2011-07-27 | 任晓艳 | Method for preparing nano-silver thread |
| CN104857556A (en)* | 2015-05-15 | 2015-08-26 | 东华大学 | Chemical grafted type long-acting sustained-release silk suture with antibacterial function and preparation method of silk suture |
| CN106474531A (en)* | 2016-11-09 | 2017-03-08 | 泰州市榕兴医疗用品股份有限公司 | A kind of suture containing antiseptic and preparation method |
- 1993
- 1993-03-19CNCN 93103280patent/CN1093004A/enactivePending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294995C (en)* | 1999-12-15 | 2007-01-17 | C·R·巴德公司 | Polymer compositions containing colloids of silver salts |
| WO2006021155A1 (en)* | 2004-08-25 | 2006-03-02 | Xiaoyan Ren | Nano-silver thread |
| WO2007089864A3 (en)* | 2006-01-30 | 2007-12-13 | Angiotech Pharm Inc | Sutures and fibrosing agents |
| CN101585088B (en)* | 2008-05-21 | 2011-07-27 | 任晓艳 | Method for preparing nano-silver thread |
| CN104857556A (en)* | 2015-05-15 | 2015-08-26 | 东华大学 | Chemical grafted type long-acting sustained-release silk suture with antibacterial function and preparation method of silk suture |
| CN106474531A (en)* | 2016-11-09 | 2017-03-08 | 泰州市榕兴医疗用品股份有限公司 | A kind of suture containing antiseptic and preparation method |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |