A kind of Exhaled nitric oxide content detection system and its detection methodTechnical field
The present invention relates to technical field of medical auxiliary equipment, in particular to a kind of Exhaled nitric oxide content detection systemsAnd its detection method.
Background technique
Exhaled nitric oxide (FeNO) detection is the inspection item that division of respiratory disease is gradually popularized.The entire air flue of people is allNitric oxide can be synthesized, Exhaled nitric oxide is typically derived from airway epithelial cell, air flue and blood vessel endothelium interstitial cellUnder nitricoxide synthase effect, arginine deamination generates endogenous nitric oxide.
Under normal physiological conditions, most of nitricoxide synthases are not expressed, and nitricoxide synthase when inflammatory conditionsIt is activated, generates a large amount of nitric oxide.Therefore, nitric oxide production content can be used as breathing to a certain extent in expiratory airThe judge index of tract disease；A kind of method that it detects airway inflammation as Noninvasive, can be repeated.Due to bronchoscopeInvasive and Sputum induction experimental technique the complexity checked, Exhaled nitric oxide detection become a kind of screening breathing diseaseThe potential tool of disease.
Exhaled nitric oxide detection by photochemical method carry out, method for by the oxidation of nitric oxide in expiratory air atThe nitrogen dioxide of the nitrogen dioxide of excitation state, excitation state is extremely unstable, can discharge the photon of particular energy and return to ground state, utilizesThe nitrogen dioxide of detector detection excitation state returns to the energy that the nitrogen dioxide of ground state is discharged, and realizes to the oxygen in expiratory airIt is quantitative to change nitrogen.Existing detection technique typically directly acquires the moisture of subject's exhalation, wherein contain a large amount of water mist, water mistIt in the presence of can absorb portion of energy, and is easy to form moisture film on the detector and influences reception of the detector to energy signal, causeSerious interference, influences testing result；Moisture film also be easy to cause detector to burn out on detector simultaneously.
Summary of the invention
Based on problem above, the present invention provides a kind of Exhaled nitric oxide content detection system and its detection method,Interference of the water mist to energy signal can be reduced, the accuracy of detection data is improved, while having evaded and having formed water on the detectorThe problem of film causes detector to burn out.
In order to solve the above technical problems, the present invention provides a kind of Exhaled nitric oxide content detection systems, including exhaleOutlet acquisition unit, expiratory air pretreatment unit, Exhaled nitric oxide detection unit, processor, information input unit, displayUnit；
Expiratory air acquisition unit is used to acquire the expiratory air in human airway, and expiratory air is delivered to expiratory air one and is aoxidizedNitrogen detection unit；
Expiratory air pretreatment unit is series between expiratory air acquisition unit and Exhaled nitric oxide detection unit, is used forWater mist in expiratory air is filtered, and retains the vaporous water in expiratory air；
Exhaled nitric oxide detection unit is for the detection to Exhaled nitric oxide content, including the oxygen interconnectedChange room and sensing chamber, oxidizing chamber is used for the oxidation of nitric oxide in expiratory air into the nitrogen dioxide of excitation state；Detection interior is setIt is equipped with detector, the nitrogen dioxide that detector is used to detect excitation state returns to the energy signal that the nitrogen dioxide of ground state is discharged,And the energy signal detected is converted into electric signal；
Processor is used to calculate nitric oxide production content in expiratory air by the electric signal received, and will test result biographyIt is handed to display unit；
Information input unit is for inputting the personal information parameter of subject into processor；
Display unit is for showing calculated nitric oxide production content and the personal information of subject.
Further, oxidant used in the oxidizing chamber in Exhaled nitric oxide detection unit is ozone.
Further, expiratory air pretreatment unit includes cyclone filter, and the cyclone filter includes cylinder, the cylinderBody upper end has top cover, is interspersed with exhaust tube on top cover, and the exhaust tube bottom is located in cylinder lumen, at the top of the exhaust tubeIt is connected to the inlet end of Exhaled nitric oxide detection unit；The cylinder body bottom is equipped with the cone cylinder being connected to cylinder lumen,Cone cylinder heavy caliber edge is connect with cartridge openings edge seal, and the cone cylinder small-caliber end is connected with to be connected to cone cylinder inner cavityLiquid collecting room；The cylinder lateral wall is provided with airintake direction and the tangent air inlet pipe of cylinder inboard wall close to top cover position, it is described intoTracheae is connected to the outlet side of expiratory air acquisition unit.
Further, the personal information parameter of information input unit input includes name, gender, age, the body of subjectTemperature, smoking history, symptom type and symptom duration.
In order to solve the above technical problems, the present invention also provides a kind of detection method of Exhaled nitric oxide content, packetInclude following operating procedure:
Step 1: acquisition subject expiratory air: subject expiratory air acquisition position include lower respiratory tract expiratory air andOne or both of nasal cavity expiratory air；
Step 2: the water mist in filtering expiratory air；
Step 3: Exhaled nitric oxide content detection: containing to nitric oxide is carried out through step 2 treated expiratory airAmount detection；Content of nitric oxide in lower respiratory tract expiratory air is controlled in expiratory air flow velocity when detecting in 50 ± 5ml/s, when continuingBetween be 6~10 seconds；Control is in expiratory air flow velocity in 5~8ml/s, duration when the content of nitric oxide detection of nasal cavity expiratory airIt is 6~10 seconds；
Step 4: input subject's personal information: inputting the personal information of subject, including surname by information input terminalName, gender, age, body temperature, smoking history, symptom type and symptom duration；
Step 5: display subject's Exhaled nitric oxide content detection result and personal information.
It further, is on-line checking or offline inspection to the content of nitric oxide detection mode in expiratory air in step 3It surveys.
Compared with prior art, the beneficial effects of the present invention are: by being arranged before Exhaled nitric oxide detection unitCyclone filter removes the water mist in expiratory air as expiratory air pretreatment unit, and remains the gaseous state in former expiratory airWater reduces interference of the water mist to energy signal, improves detection data under the conditions of not influencing the gaseous component in expiratory airAccuracy, while having evaded and having formed moisture film the problem of causing detector to burn out on the detector.
Detailed description of the invention
Fig. 1 is the structural block diagram of respiratory disorder detection system of the invention；
Fig. 2 be embodiment 1 in cyclone filter, oxidizing chamber, sensing chamber connection schematic diagram；
Fig. 3 is the top view of the cyclone filter in Fig. 2；
Fig. 4 is the flow chart of one of embodiment 2 Exhaled nitric oxide detection method of content；
Wherein, 1, expiratory air acquisition unit；2, expiratory air pretreatment unit；3, Exhaled nitric oxide detection unit；4,Processor；5, information input unit；6, display unit；7, oxidizing chamber；8, sensing chamber；9, detector；10, cylinder；11, it is ventedCylinder；12, cone cylinder；13, liquid collecting room；14, air inlet pipe.
Specific embodiment
The present invention is further illustrated with reference to the accompanying drawings and embodiments, but not as a limitation of the invention.
Embodiment 1:
Referring to Fig. 1-3, a kind of Exhaled nitric oxide content detection system and its detection method, including expiratory air acquisition are singleFirst 1, expiratory air pretreatment unit 2, Exhaled nitric oxide detection unit 3, processor 4, information input unit 5, display unit6；
Expiratory air acquisition unit 1 is used to acquire the expiratory air in human airway, and expiratory air is delivered to one oxygen of expiratory airChange nitrogen detection unit 3；
Expiratory air pretreatment unit 2 is series between expiratory air acquisition unit 1 and Exhaled nitric oxide detection unit 3,For being filtered to the water mist in expiratory air, and retain the vaporous water in expiratory air；
Exhaled nitric oxide detection unit 3 is for the detection to Exhaled nitric oxide content, including what is interconnectedOxidizing chamber 7 and sensing chamber 8, oxidizing chamber 7 are used for the oxidation of nitric oxide in expiratory air into the nitrogen dioxide of excitation state；Sensing chamberDetector 9 is provided in 8, the nitrogen dioxide that detector 9 is used to detect excitation state returns to the energy that the nitrogen dioxide of ground state is dischargedSignal is measured, and the energy signal detected is converted into electric signal；
Processor 4 is used to calculate nitric oxide production content in expiratory air by the electric signal received, and will test resultIt is transferred to display unit 6；
Information input unit 5 is for inputting the personal information parameter of subject into processor 4；
Display unit 6 is for showing calculated nitric oxide production content and the personal information of subject.
Oxidant used in oxidizing chamber 7 in Exhaled nitric oxide detection unit 3 is ozone.
Expiratory air pretreatment unit 2 includes cyclone filter, and the cyclone filter includes cylinder 10, on the cylinder 10End has top cover, is interspersed with exhaust tube 11 on top cover, 11 bottom of exhaust tube is located in 10 inner cavity of cylinder, the exhaust tube 11Top is connected to the inlet end of Exhaled nitric oxide detection unit 3；10 bottom of cylinder is equipped with to be connected with 10 inner cavity of cylinderLogical cone cylinder 12, the 12 heavy caliber edge of cone cylinder and 10 open edge of cylinder are tightly connected, and 12 small-caliber end of cone cylinder connectsIt is connected to the liquid collecting room 13 being connected to 12 inner cavity of cone cylinder；10 side wall of cylinder is provided with airintake direction and cylinder close to top cover positionThe tangent air inlet pipe 14 of 10 inner walls, the air inlet pipe 14 are connected to the outlet side of expiratory air acquisition unit 1.
In the present embodiment, expiratory air acquisition unit 11 pre-processes the expiratory air input expiratory air of collected subjectUnit 2, expiratory air pretreatment unit 2 are cyclone filter, and expiratory air is entered by air inlet pipe 14 along 10 inner wall tangential direction of cylinderCylinder 10 forms eddy flow in cylinder 10；Expiratory air constantly enters in cylinder 10, makes expiratory air in cylinder 10 close to cylinder 10Spiral inner wall moves down, and is gradually moved to 10 inner wall of cylinder under the action of the centrifugal force；Because the water mist in expiratory air is liquid stateLittle particle, can gradually be moved to 10 inner wall of cylinder under the influence of centrifugal force, and accumulate water flow through cone cylinder 12 flow into liquid collectingRoom 13 is not influencing vaporous water；Expiratory air after removing water mist then forms rebound in 12 inner wall of cone cylinder and moves up, finally through arrangingInflator 11 enters Exhaled nitric oxide detection unit 3, realizes gas-liquid separation in expiratory air.
Oxidant in the oxidizing chamber 7 of Exhaled nitric oxide detection unit 3 is ozone, and the expiratory air after demisting entersOxidizing chamber 7, it is defeated immediately after nitric oxide and ozone reaction in expiratory air generate the nitrogen dioxide of excitation state in oxidizing chamber 7It send to sensing chamber 8, the volume photon that the nitrogen dioxide of excitation state discharges particular energy in sensing chamber 8 returns to ground state, and detector 9 connectsThe energy of photon is received, and is converted into electric signal.The photon energy wherein received gets over multilist and shows nitric oxide production contentHigher, electrical signal intensity is higher, and the content of nitric oxide of subject is calculated through processor 4.Information input unit 5 is to processorThe personal information such as gender, age, body temperature, smoking history, symptom type and symptom durations of input subjects in 4, and are examinedThe result of the Exhaled nitric oxide of survey passes through display unit 6 together and shows, is correctly treated conducive to doctor to subject.
Embodiment 2:
Referring to fig. 4, a kind of detection method of Exhaled nitric oxide content, including following operating procedure:
Step 1: acquisition subject expiratory air: subject expiratory air acquisition position include lower respiratory tract expiratory air andOne or both of nasal cavity expiratory air；
Step 2: the water mist in filtering expiratory air；
Step 3: Exhaled nitric oxide content detection: containing to nitric oxide is carried out through step 2 treated expiratory airAmount detection；Content of nitric oxide in lower respiratory tract expiratory air is controlled in expiratory air flow velocity when detecting in 50 ± 5ml/s, when continuingBetween be 6~10 seconds；Control is in expiratory air flow velocity in 5~8ml/s, duration when the content of nitric oxide detection of nasal cavity expiratory airIt is 6~10 seconds；
Step 4: input subject's personal information: inputting the personal information of subject, including surname by information input terminalName, gender, age, body temperature, smoking history, symptom type and symptom duration；
Step 5: display subject's Exhaled nitric oxide content detection result and personal information.
In the present embodiment, contained according to the Exhaled nitric oxide that the actual symptoms of subject may be selected to carry out corresponding siteAmount detection.When the main malaise symptoms of subject are cough, expectoration, asthma, abscess of throat, the symptoms such as be short of breath, should acquire byThe lower respiratory tract expiratory air of examination person, acquisition mode is that soft palate is closed when exhaling, by the air-flow of the exhalation of oral cavity acquisition subject, thenIt carries out corresponding expiratory air pretreatment, exhaled air flow speed is controlled when content of nitric oxide detects in 50 ± 5ml/s, the duration is6~10 seconds.Relative to lower respiratory tract, nasal cavity Exhaled nitric oxide can accumulate higher concentration, therefore to lower breathingWhen the expiratory air sampling in road, it should be closed soft palate, prevent expiratory air in nasal cavity from entering, influence the detection knot of lower respiratory tract expiratory airFruit.
Whens the uncomfortable diseases of subject are mainly shown as intermittent nasal obstruction, runny nose, sneezing etc., the nasal cavity of subject should be acquiredExpiratory air, acquisition mode is to make gas full of two nostrils during holding one's breath using oral cavity natural aspiration, then by single or twoIt exhales in a nostril；Corresponding expiratory air pretreatment is carried out again, and exhaled air flow speed is controlled when content of nitric oxide detects in 5 ± 8ml/S, duration are 6~10 seconds.
It is on-line checking or offline inspection to the content of nitric oxide detection mode in expiratory air in step 3.On-line checkingFast speed can quickly be judged.But different subject's coutroi velocities is inconsistent, easily leads to detection data poor repeatability,It can be used for tentatively judging；Offline inspection can control Ventilation Rate, guarantee the repeatability of testing result, at the same can far from instrument intoRow sampling meets remote detection demand.But sample be easy to cause sample to pollute in storage, transportational process, and detection time is long, nothingMethod realizes immediate assessment.Two kinds of detection modes respectively have superiority and inferiority, can select corresponding detection mode according to the actual conditions of subject,Meets the needs of different.
It as above is the embodiment of the present invention.Design parameter in above-described embodiment and embodiment is merely to understand tableInvention verification process is stated, the scope of patent protection being not intended to limit the invention, scope of patent protection of the invention is still with itIt is all to change with equivalent structure made by specification and accompanying drawing content of the invention subject to claims, it should all similarly wrapContaining within the scope of the present invention.