Alternatively, depending on the difference in the degree of tolerance of the patient to different chemotherapeutic drugs, other pi-conjugated compounds may be used for adjunctive therapy, for example: curcumin (curcumin).

Detailed description of the invention

Detailed description of the invention

From the above, the various pi conjugated nano self-assembled particles provided by the invention are directly injected into the tumor to inject the embolism tumor blood vessel anticancer agent, so that local embolism of tumor blood vessels can be caused in the tumor through the self-assembly of the nano particles, the transmission of oxygen and nutrients to tumor tissues through blood is prevented, and further, on the basis of embolism, tumor cells are starved to prevent the diffusion and the metastasis of the tumor. Compared with the prior art, the novel medicine and the medical method provided by the invention can reduce the medical cost and relieve the pain of patients on the premise of effectively improving the tumor cure rate, and have obvious technical progress.

It should be noted that the scope of the present invention includes but is not limited to the above embodiments, and those skilled in the art can develop other embodiments based on the above embodiments, and any simple modification or equivalent replacement without departing from the innovative concept of the present invention is covered by the present invention and belongs to the scope of the present invention.

Claims

Translated fromChinese

1.一种π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂，其特征在于：1. a π-conjugated nanometer self-assembled particle intratumoral injection embolizing tumor blood vessel anticancer agent is characterized in that:

该π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂为粒径介于100nm-300nm之间的纳米颗粒；并且，该π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂是由两亲性的π共轭化合物制作而成的；The π-conjugated nano-self-assembled particle intratumorally injected tumor blood vessel embolizing anti-cancer agent is a nanoparticle with a particle size between 100nm-300 nm; It is made from amphiphilic π-conjugated compounds;

所述两亲性的π共轭化合物为金丝桃素或姜黄素或金丝桃素和姜黄素的混合物。The amphiphilic π-conjugated compound is hypericin or curcumin or a mixture of hypericin and curcumin.

2.根据权利要求1所述的π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂，其特征在于：所述两亲性的π共轭化合物可以在肿瘤微环境内通过自组装而团聚。2. The π-conjugated nano-self-assembled particle intratumorally injected anti-cancer agent for embolizing tumor blood vessels according to claim 1, wherein the amphiphilic π-conjugated compound can be self-assembled in the tumor microenvironment. reunion.

3.根据权利要求2所述的π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂，其特征在于：所述两亲性的π共轭化合物可以在pH＝6.5的肿瘤微环境内通过自组装而团聚。3. The intratumoral injection of the π-conjugated nano-self-assembled particle anti-cancer agent for embolizing tumor blood vessels according to claim 2, wherein the amphiphilic π-conjugated compound can be in the tumor microenvironment of pH=6.5 reunite by self-assembly.

4.根据权利要求1所述的π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂，其特征在于：该π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂能够在肿瘤微环境内、在低频率聚焦超声的作用下通过自组装团聚成粒径达到微米级别或者厘米级别的栓塞物。4. The intratumoral injection of the π-conjugated nano-self-assembled particle anti-cancer agent for embolizing tumor blood vessels according to claim 1, characterized in that: the intratumoral injection of the π-conjugated nano-self-assembled particle intratumoral injection of the anti-cancer agent for embolizing tumor blood vessels can be used in tumors. In the microenvironment, under the action of low-frequency focused ultrasound, self-assembly and agglomeration are performed to form emboli with a particle size of the micron level or centimeter level.

5.根据权利要求4所述的π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂，其特征在于：所述栓塞物的粒径大于2000nm。5 . The anticancer agent for intratumoral injection of π-conjugated nano-self-assembled particles for embolizing tumor blood vessels according to claim 4 , wherein the particle size of the emboli is greater than 2000 nm. 6 .

6.根据权利要求1-5中任一项权利要求所述的π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂，其特征在于：该π共轭纳米自组装颗粒瘤内注射栓塞肿瘤血管抗癌剂的粒径为250nm。6 . The anticancer agent for intratumoral injection of π-conjugated nano-self-assembled particles according to any one of claims 1 to 5, characterized in that: the intra-tumoral injection of the π-conjugated nano-self-assembled particles for embolization The particle size of the tumor vascular anticancer agent is 250 nm.