A kind of control method of duck plague diseaseTechnical field
The invention belongs to cultural technique fields, and in particular to a kind of control method of duck plague disease
Background technique
Duck, duck are the general designations of Anseriformes Anatidae duck subfamily aquatic bird, mainly with the toy (fish, shrimp, loach etc.) in water,Plant (water plant, barnyard grass, rice etc.) is food.It is divided into laying duck and duckling, duck's egg nutritive value is high, the fatty acid fusing point in duckIt is low, it is easy to digest.Contained B family vitamin and vitamin E are more compared with other meats, are highly resistant to athlete's foot, neuritis and a variety ofInflammation, moreover it is possible to anti-aging.Contain niacin more abundant in duck, it be constitute two kinds of important coenzyme in human body at point itOne, there is protective effect to heart disease patients such as myocardial infarctions.
Duck plague (Duck plape0) also known as duck viral enteritis (Duck virusenteritis, DVE), be duck, goose andA kind of acute, hot, Septic blood infectious disease of other Anseriformes birds.The disease is characterized in prevalence extensively, propagates morbidity rapidlyRate and the death rate are all high.This disease is found for the first time in Holland early in nineteen twenty-three BaudetShi, until BosShi in 1940 is put forward for the first time duckThe title of pest, and confirm it is a kind of new virus disease different from checken pest.Currently, there is no specific drug, often aim at prevention, except carrying outOutside biological safety measure, the occurrence of this disease can effectively be prevented by carrying out immunity inoculation using duck plague attenuated live vaccines.Duck mass-sendingWhen sick, to healthy duck group or suspected infection duck, 3-4 times of amount of duck plague vaccine should be taken promptly to be inoculated with immediately；To sick duck, everyThe duck plague hyper-immune serum duck poison of the great high-tech of intramuscular injection state is 0.5 milliliter or 0.5-1 milliliters of poly IC anti-, injects 1 time within every 3 days, 2-3 is used in conjunctionIt is secondary, carry out early treatment.The mixed drink of water can also be mixed with Moroxydine Hydrochloride soluble powder or Enrofloxacin soluble powder, it is l-2 times daily,It is used in conjunction 3-5 days, but is not applied to laying ducks, meat duck is pre-sales should to be discontinued 8 days.The same slaughter of sick duck and buried processing.It is right simultaneouslyThe all goods that sick duck may contact carry out thorough disinfection.But above-mentioned therapeutic effect is to be improved, and medicament residue is caused to pollute,It is unfavorable for the production of duck product.
Summary of the invention
Of the existing technology to overcome the problems, such as, the present invention provides a kind of control method of duck plague disease, this method is usedAcyclovir, rimantadine hydrochloride, joint injection agent made of dipyrimidinol carry out intramuscular injection to sick duck, rapid-action,For preventing and treating duck plague disease, effect highly significant, prevention and treatment is simply.
Specifically, the present invention provides a kind of control methods of duck plague disease, comprising the following steps:
(1) preparation of duck plague disease injection: take acyclovir 1-4g, rimantadine hydrochloride 1-4g, dipyrimidinol 2-6g,It is put into injection water 600-800ml, holding temperature is 60-70 DEG C of stirring and dissolving, hyperfiltration, the hydroxide of 0.5mol/LIt is 7.0-7.5 that sodium solution, which adjusts PH, and encapsulating sterilizes 30 minutes through 115 DEG C, pressure 0.2MPa, and every 5ml obtains injection；
(2) treatment of duck plague disease: illness duck is rejected into isolation treatment, gives injection injection 2-5ml of the present invention.
(3) duck plague disease is prevented: to sick duck is not suffering from, only being prevented using injection intramuscular injection 1-3ml/ of the invention.
Further, acyclovir 2-3g, rimantadine hydrochloride the preparation of the step (1) duck plague disease injection: are taken2-3g, dipyrimidinol 3-5g, it is put into injection water 650-750ml, holding temperature is 60-70 DEG C of stirring and dissolving, ultra microFiltering, it is 7.0-7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating sterilizes 30 minutes through 115 DEG C, pressure 0.2MPa,Every 5ml, obtains injection；
Still further, the preparation of (1) duck plague disease injection: taking acyclovir 2.5g, rimantadine hydrochloride2.5g, dipyrimidinol 4g, be put into injection water 700ml, holding temperature be 65 DEG C of stirring and dissolvings, hyperfiltration,It is 7.0-7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating sterilizes 30 minutes, every through 115 DEG C, pressure 0.2MPa5ml obtains injection；
The injection PH is preferably adjusted to 7.3；
The treatment of described step (2) the duck plague disease: illness duck is rejected into isolation treatment, gives injection injection of the present invention3.5ml。
Step (3) the duck plague disease prevention: to sick duck is not suffering from, only using injection intramuscular injection 2ml/ of the inventionPrevention.
The invention has the benefit that
The method of the present invention is using joint injection agent made of acyclovir, rimantadine hydrochloride, dipyrimidinol, to sick duckIntramuscular injection is carried out, rapid-action, for preventing and treating duck plague disease, effect highly significant, prevention and treatment is simply.Cure rate is up to 91%, in advanceIt is anti-efficient up to 99%.
Specific embodiment
Below with reference to preferred embodiment, the present invention is further explained.It should be understood that these embodiments are merely to illustrateThe present invention rather than limit the scope of the invention.In addition, it should also be understood that, after reading the contents of the present invention, this fieldTechnical staff can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claimsLimited range.
The preparation of 1 duck plague disease injection of embodiment
It takes acyclovir 1g, rimantadine hydrochloride 1g, dipyrimidinol 2g, be put into injection water 600ml, heat preservation temperatureDegree is 60 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.0 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 2 duck plague disease injection of embodiment
It takes acyclovir 2g, rimantadine hydrochloride 2g, dipyrimidinol 3g, be put into injection water 650ml, heat preservation temperatureDegree is 60 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.0 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 3 duck plague disease injection of embodiment
It takes acyclovir 2.5g, rimantadine hydrochloride 2.5g, dipyrimidinol 4g, be put into injection water 700ml, protectTemperature is 65 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.3 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C,Pressure 0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 4 duck plague disease injection of embodiment
It takes acyclovir 3g, rimantadine hydrochloride 3g, dipyrimidinol 5g, be put into injection water 800ml, heat preservation temperatureDegree is 70 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 5 duck plague disease injection of embodiment
It takes acyclovir 4g, rimantadine hydrochloride 4g, dipyrimidinol 5g, be put into injection water 800ml, heat preservation temperatureDegree is 70 DEG C of stirring and dissolvings, and hyperfiltration, it is 7.5 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, encapsulating, through 115 DEG C, pressure0.2MPa sterilizes 30 minutes, and every 5ml obtains injection；
The preparation of 6 duck plague disease injection of embodiment
It takes acyclovir 2.5g, rimantadine hydrochloride 2.5g, be put into injection water 700ml, holding temperature is 65 DEG CStirring and dissolving, hyperfiltration, it is 7.3 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating is gone out through 115 DEG C, pressure 0.2MPaBacterium 30 minutes, every 5ml obtained injection；
The preparation of 7 duck plague disease injection of embodiment
It takes rimantadine hydrochloride 2.5g, dipyrimidinol 4g, be put into injection water 700ml, holding temperature is 65 DEG CStirring and dissolving, hyperfiltration, it is 7.3 that the sodium hydroxide solution of 0.5mol/L, which adjusts PH, and encapsulating is gone out through 115 DEG C, pressure 0.2MPaBacterium 30 minutes, every 5ml obtained injection；
The duck plague injection control efficiency of the present invention of test example 1 is investigated
800 duck plague sick ducks are randomly divided into 8 groups, test group 1-7 uses injection made from 1-7 of the embodiment of the present invention respectivelyIt is treated, control group is treated using anti-0.5 milliliter of duck plague hyper-immune serum duck poison of the great high-tech of intramuscular injection state；Investigate result such asThe following table 1:
The duck plague injection control efficiency of the present invention of table 1 is investigated
It is above-mentioned experiments have shown that, the present invention made of injection for prevent and treat duck plague disease, effect is preferable, and treatment cost is low,It is easily operated.