Summary of the invention
The disclosure solves the problems, such as that being to provide a kind of good sample container for nucleic acid extraction instrument of heating effect addsThermal and nucleic acid extraction instrument.
To achieve the goals above, according to one aspect of the disclosure, a kind of sample for nucleic acid extraction instrument is providedContainer heating device, the sample container heating device include driving mechanism and assemble on pedestal for being mounted on can heat sampleThe heating structure of this container, the heating structure can adjust position along short transverse by the driving mechanism to have idle positionIt sets and operating position, in the rest position, the heating structure is retracted relative to the assembly pedestal, in the working positionIt sets, the heating structure is prominent relative to the assembly pedestal, is formed with and the sample in the heating surface of the heating structureThe corresponding heating groove of the bottom shape of this container.
Optionally, the driving mechanism includes drive rod, which is arranged in the assembly pedestal with extending transverselyCorresponding to the position of the heating structure, and a part of the drive rod is located at the lower section of the heating structure and adds with describedHeat structure cooperation is can drive the heating structure to adjust position along the short transverse.
Optionally, the drive rod can laterally adjust position, and the drive rod along described on the assembly pedestalIt is described a part with the heating structure by fit structure mutual cooperation so that the heating structure is in the drive rodDriving under can along the short transverse adjust position.
Optionally, the fit structure includes prominent described a part for being formed in the drive rod above and has inclined surfaceFitting projection and be arranged in the heating structure bottom and with the inclined surface roll cooperation pulley.
Optionally, the heating structure penetrates through the bottom of the assembly pedestal and the heating structure along the short transverseIt is provided with support base, there is compartment of terrain to be fixed on the support base for the pulley and the heating structure, the drive rodDescribed a part is mounted in the support base and the position between the pulley and the heating structure, described idlePosition, the tip contact of the pulley and the inclined surface, in the operating position, the bottom end of the pulley and the inclined surfaceContact.
Optionally, the drive rod is formed as zigzag shape, and the both ends of the drive rod are higher than institute in the short transverseDescribed a part of drive rod is stated, and the both ends are supported on the assembly pedestal respectively along the transverse movable.
Optionally, the driving mechanism further includes that the outside of the assembly pedestal can be mounted on along the transverse movableOperating block, which is connected to the outer end of the drive rod for driving the drive rod to laterally adjust position described in.
Optionally, it is formed with cam in described a part of the drive rod, the heating structure and the cam rollRotation with drive rod described in merga pass and can along the short transverse adjust position.
Optionally, the heating structure includes having the heat block of the heating surface and being arranged in the heat blockBottom and the heater circuit plate for being used to heat the heat block.
According to another aspect of the present disclosure, a kind of nucleic acid extraction instrument is also provided, which includes assembly bottomSeat, deep-well plates and the sample container heating device as described above for being used for nucleic acid extraction instrument, the heating structure are mounted onOn the assembly pedestal, the sample container be the deep-well plates, the deep-well plates be movably disposed on the assembly pedestal andThe top of the heating structure can be located in the short transverse.
Through the above technical solutions, that is, sample container heating device is assembled to assembly pedestal on when, in working conditionUnder, by the driving of driving mechanism so that heating structure is prominent relative to assembly pedestal in the height direction, herein due to heatingStructure correspond to sample container heating surface on be formed with heating groove corresponding with the bottom shape of sample container, thusThe bottom of heating groove and sample container is enabled to realize face heating method, thus, it is possible to the sample progress in sample containerIt is evenly heated and there is good heating effect.
Other feature and advantage of the disclosure will the following detailed description will be given in the detailed implementation section.
Detailed description of the invention
Attached drawing is and to constitute part of specification for providing further understanding of the disclosure, with following toolBody embodiment is used to explain the disclosure together, but does not constitute the limitation to the disclosure.In the accompanying drawings:
Fig. 1 is the partial structurtes according to the sample container heating device of disclosure specific embodiment in the assembled conditionFigure；
Fig. 2 is to be located at rest position in the assembled condition according to the sample container heating device of disclosure specific embodimentWhen the internal structure chart for showing heating structure；
Fig. 3 is to be located at operating position in the assembled condition according to the sample container heating device of disclosure specific embodimentWhen the internal structure chart for showing heating structure；
Fig. 4 is the top view of Fig. 3；
Fig. 5 is the bottom view of Fig. 3.
Description of symbols
1 assembly 2 heating structure of pedestal
3 heating 4 drive rods of groove
5 fitting projection, 6 pulley
7 support base, 8 mounting hole
9 operating block, 10 heat block
11 heater circuit plate, 12 inclined surface
13 deep-well plates, 14 heat-insulating base
A short transverse B is lateral
C is longitudinal
Specific embodiment
It is described in detail below in conjunction with specific embodiment of the attached drawing to the disclosure.It should be understood that this place is retouchedThe specific embodiment stated is only used for describing and explaining the disclosure, is not limited to the disclosure.
In the disclosure, in the absence of explanation to the contrary, the noun of locality used such as " upper and lower ", " inside and outside " and " bottomPortion " typically refers to " upper and lower ", " inside and outside " and " bottom " of the corresponding component of sample container heating device in a state of use, separatelyOutside, the term " short transverse " that uses, " transverse direction ", " longitudinal direction " typically refer to " short transverse " shown in respective drawings, " horizontalTo ", " longitudinal direction ".
As shown in Figures 1 to 5, according to one aspect of the disclosure, a kind of sample appearance for nucleic acid extraction instrument is providedDevice heating device, the sample container heating device include driving mechanism and assemble on pedestal 1 for being mounted on can heat sampleThe heating structure 2 of this container, the heating structure 2 can adjust position along short transverse A by the driving mechanism to have the spare timeSeated position and operating position, in the rest position, the heating structure 2 is retracted relative to the assembly pedestal 1, in the workMake position, the heating structure 2 is prominent relative to the assembly pedestal 1, be formed in the heating surface of the heating structure 2 withThe corresponding heating groove 3 of the bottom shape of the sample container.Pass through structure as described above, that is, add by sample containerWhen thermal is assembled on assembly pedestal 1, in the operating condition, by the driving of driving mechanism so that heating structure 2 is in heightIt is prominent relative to assembly pedestal 1 on the A of direction, it is formed at this since heating structure 2 corresponds in the heating surface of sample containerHeating groove 3 corresponding with the bottom shape of sample container, so that the bottom of heating groove 3 and sample container is realExisting face heating method has good heating effect thus, it is possible to be evenly heated to the sample in sample container.In addition,In a non-operative state, by the driving of driving mechanism so that heating structure 2 contracts on short transverse A relative to assembly pedestal 1Return so that nucleic acid extraction instrument inner space shared by sample container minimize, thus avoid sample container heating device withOther structures interfere and are convenient for the work of other component, so that the total of nucleic acid extraction instrument is more reasonableChange.
Here, driving mechanism can use the structure of various reasonable, as long as driving heating structure 2 can be played along height sideTo the function of A adjustment position.
For example, optionally, the driving mechanism includes drive rod 4, transversely B extends ground setting described to the drive rod 4The position that pedestal 1 corresponds to the heating structure 2 is assembled, and a part of the drive rod 4 is located under the heating structure 2Just and with the heating structure 2 cooperate so that the heating structure 2 can be driven to adjust position along the short transverse A.Here, drivingLever 4 can take various forms that heating structure 2 is driven to adjust position along short transverse A, for example, the drive rod 4 can be withThe mode that is moved by the way of moving in transverse direction, along short transverse or along the mode of own axis driving plusHeat structure 2 adjusts position along short transverse A, and can be using any for the fit structure between drive rod 4 and heating structure 2Mode appropriate adjusts position along short transverse A as long as can be realized driving heating structure 2.Pass through drive rod 4 as a result,Heating structure 2 can be easily driven to adjust position along short transverse A.In addition, the drive rod 4 in the assembled condition can be with clothIt sets in the lower section of assembly pedestal 1, therefore without the inner space for occupying nucleic acid extraction instrument, so that inside nucleic acid extraction instrumentStructure arrangement is more rationalized.But it's not limited to that for the disclosure, and the driving mechanism can also use other structures, such as driveMotivation structure can be using lifting device, driving cylinder, link mechanism etc., as long as realizing can drive heating structure 2 along short transverse AAdjust the function of position.
Optionally, the drive rod 4 can adjust position, and the driving on the assembly pedestal 1 along the transverse direction BDescribed a part of bar 4 is cooperated with the heating structure 2 by fit structure, so that the heating structure 2 is describedUnder the driving of drive rod 4 position can be adjusted along the short transverse A.That is, drive rod 4 and heating structure 2 pass through fit structureMutual cooperation and can be pushed in drive rod 4 transversely B moving process heating structure 2 along short transverse A adjust position,The mutual conversion being achieved between rest position and operating position.Here, fit structure can use a variety of structures appropriate.For example, optionally, the fit structure includes prominent described a part for being formed in the drive rod 4 above and has inclined surface 12Fitting projection 5 and be arranged in 2 bottom of heating structure and with the inclined surface 12 roll cooperation pulley 6.Here, working asWhen described a part of drive rod 4 is arranged in the position between heating structure 2 and pulley 6, fitting projection 5 is towards drive rod 4The lower section of described a part is prominent.In the case, on the rest position, the top of pulley 6 and the inclined surface 12 of fitting projection 5End in contact, in operating position, pulley 6 is contacted with the bottom end of the inclined surface 12 of fitting projection 5.And when described one of drive rod 4When point being arranged in the lower position of pulley 6, fitting projection 5 towards drive rod 4 described a part top protrusion.In this situationUnder, in rest position, pulley 6 is contacted with the bottom end of the inclined surface 12 of fitting projection 5, in operating position, pulley 6 and fitting projectionThe tip contact of 5 inclined surface 12.In addition, fit structure as described above can on the drive rod 4 arranged for interval have it is moreIt is a can be reliable and to be stably driven with the heating decoupling stock 2 along short transverse A adjustment position.In addition, the inclined surface 12It can be the inclination flat face with predetermined inclination angle, or may be curved inclined surface.For operating position and idle positionThe conversion regime set can transversely be realized by the way of B is moved back and forth using drive rod 4, can also use the transversely B of drive rod 4The mobile mode of a side direction realize, be arranged symmetrically at this point, the inclined surface 12 of fitting projection 5 is effectively used with center lineCurved inclined surface.But it's not limited to that for the disclosure, can carry out fit structure described in reasonable design according to actual needs.
Optionally, as shown in Fig. 2, Fig. 3 and Fig. 5, the heating structure 2 penetrates through the assembly bottom along the short transverse AThe bottom of seat 1 and the heating structure 2 is provided with support base 7, and the pulley 6 is fixed with the heating structure 2 with compartment of terrainOn the support base 7, described a part of the drive rod 4 is mounted in the support base 7 and is located at the pulley 6 and instituteThe position between heating structure 2 is stated, in the rest position, the tip contact of the pulley 6 and the inclined surface 12, describedOperating position, the pulley 6 are contacted with the bottom end of the inclined surface 12.Wherein, support base 7 can be formed as U-shaped seat and canTo be fixed on assembly pedestal 1 by fasteners such as bolts.By structure as described above, in drive rod 4, transversely B is mobileIn the process, the inclined surface 12 of fitting projection 5 is cooperated by rolling with pulley 6, so that being fixed on heating structure 2 by support base 7On pulley 6 drive heating structure 2 along short transverse A adjust position, from there through it is as described above simply structure come reliablyRealize heating structure 2 relative to the movement that assembly pedestal 1 is prominent or retracts.But it's not limited to that for the disclosure, can also useOther reasonable structures.
Optionally, the drive rod 4 is formed as zigzag shape, and the both ends of the drive rod 4 are higher than on the short transverse ADescribed a part of the drive rod 4, and the both ends are movably supported at the assembly pedestal 1 along the transverse direction B respectivelyOn.The drive rod 4 can save the assembly space of assembly pedestal 1 as a result, for other component, so that can on assembly pedestal 1More reasonably arrange other structures, simultaneously because the most of lower section for being arranged in assembly pedestal 1 of drive rod 4 and in the course of workIn will not with assembly pedestal 1 on other structures interfere, guarantee the reliable operating of whole equipment.
Optionally, the driving mechanism further includes that can be movably mounted at the assembly pedestal 1 along the transverse direction BThe operating block 9 in outside, the operating block 9 are connected to the outer end of the drive rod 4 for driving the drive rod 4 along the transverse directionB adjusts position.In the case where the sample container heating device of the disclosure is assembled to nucleic acid extraction instrument, such as Fig. 2 and Fig. 3 instituteShow, the assembly pedestal 1 of nucleic acid extraction instrument is formed on the surface corresponding to the close outside of the drive rod 4 along the transverse directionThe mounting hole 8 that B extends, the operating block 9 is movably mounted on the mounting hole 8 along the transverse direction B, and the operating block9 are connected to the outer end of the drive rod 4 so that transversely B adjusts position for driving the drive rod 4.Thus, it is possible to logicalOperator is crossed to automatically control operating block 9 either manually or by controller and can easily drive the transversely B adjustment position of drive rod 4It sets, drives heating structure 2 along height side by the rolling cooperation of the inclined surface 12 of fitting projection 5 and pulley 6 in the processPosition is adjusted to A, to easily realize switching of the heating structure 2 between rest position and operating position.In addition, for addingHeat structure 2 is locked in rest position or the lock mode of operating position can be using a variety of arragement constructions, such as can use logicalIt crosses and the structures such as operating block 9, drive rod 4 or pulley 6 is realized into line-locked locking structure, the disclosure does not limit this.
Optionally, according to another embodiment of the disclosure, it is formed with cam in described a part of the drive rod, instituteIt states heating structure 2 and the cam rolls the rotation with drive rod described in merga pass and can adjust along the short transverse APosition.That is, the cylindrical body that transversely B extends can be formed as in this drive rod, drive rod around 90 ° of own axis orDuring 180 ° of equal rotational angles, drive heating structure 2 along short transverse A tune by the cooperation of cam and heating structure 2Whole position, that is, contacted in the lowermost end of rest position, the cam with heating structure 2, in operating position, the cam is mostTop is contacted with heating structure 2.At this point it is possible to realize heating structure 2 in idle position by the plain mode for locking drive rodIt sets or the locking of operating position.
Optionally, the heating structure 2 includes having the heat block 10 of the heating surface and being arranged in the heatingThe bottom of block 10 and the heater circuit plate 11 for being used to heat the heat block 10.Wherein, the heating structure 2 can be by heat-insulatedOn assembly pedestal 1, wherein heat-insulating base 14 can be fixed on assembly pedestal 1 14 setting of seat by fasteners such as bolts, and be addedHeat structure 2 can be prominent relative to assembly pedestal 1 on heat-insulating base 14 or be retracted.The bottom of heater circuit plate 11 can be setConductive stud, in operating position, the heating groove 3 of heat block 10 is moved on the position corresponding to the bottom of sample container, itAfterwards by powering to conductive stud so that heater circuit plate 11 is towards 10 heat release of heat block, thus the heating groove on heat block 103 can be uniformly heated up the sample in sample container, improve heating efficiency.
In addition, heating structure 2 can C arranged for interval there are multiple groups along longitudinal direction on assembly pedestal 1, and can according to need,It is arranged with corresponding driving mechanism on each heating structure 2, or drive can also be passed through by multiple heating structures 2Motivation structure and it is prominent relative to assembly pedestal 1 in linkage or retract, in this regard, the disclosure does not limit.
According to another aspect of the present disclosure, a kind of nucleic acid extraction instrument is also provided, as shown in Figure 1, the nucleic acid extraction instrumentIt is described to add including assembly pedestal 1, deep-well plates 13 and the sample container heating device as described above for being used for nucleic acid extraction instrumentHeat structure 2 is mounted on the assembly pedestal 1, and the sample container is the deep-well plates 13, which is movably disposedThe top of the heating structure 2 can be located on the assembly pedestal 1 and on the short transverse A.Here, working as deep-well platesIn the case that 13 are moved into the top position of heating structure 2, by the driving of driving mechanism so that heating structure 2 is in height sideIt is prominent relative to assembly pedestal 1 on A, so that the heating groove 3 of heating structure 2 is corresponding with the bottom surface of deep-well plates 13,So that face heating method is realized in the bottom of heating groove 3 and sample container, thus, it is possible to the sample in sample containerThis is evenly heated and has good heating effect, so that the sample in deep-well plates 13 sufficiently reacts, is guaranteed eachThe consistency of the cracking of sample and elution efficiency etc..In addition, in a non-operative state, by the driving of driving mechanism so that heatingStructure 2 retracts on short transverse A relative to assembly pedestal 1, so that empty inside nucleic acid extraction instrument shared by sample containerBetween minimize, to avoid sample container heating device and other structures interfere and are convenient for the work of other component, thusSo that the total of nucleic acid extraction instrument is more rationalized.
The preferred embodiment of the disclosure is described in detail in conjunction with attached drawing above, still, the disclosure is not limited to above-mentioned realityThe detail in mode is applied, in the range of the technology design of the disclosure, a variety of letters can be carried out to the technical solution of the disclosureMonotropic type, these simple variants belong to the protection scope of the disclosure.
It is further to note that specific technical features described in the above specific embodiments, in not lanceIn the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the disclosure to it is various canNo further explanation will be given for the combination of energy.
In addition, any combination can also be carried out between a variety of different embodiments of the disclosure, as long as it is without prejudice to originallyDisclosed thought equally should be considered as disclosure disclosure of that.