Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, completeSite preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based onEmbodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every otherEmbodiment shall fall within the protection scope of the present invention.
Implantation equipment wirelessly carries out communication and/capacitor fill/powers to et al. Ke battery.It plantsEnter equipment and generally comprises circuit board, charging and communication coil, battery, output electrode and several sampling resistors.The embodiment of the present inventionIn tested implantation equipment do not include battery or capacitor.
The embodiment of the present invention provide it is a kind of for detecting the Auto-Test System of implantation medical instrument, as shown in Figure 1, this isSystem includes: displacement tooling 11, power supply 12 and computer 13.It shifts tooling 11 and is equipped with charging programmable device 14 and test board 16, movePosition tooling 11 is for changing charging programmable device 14 and the tested relative position for being implanted into equipment 15.
There are many selections for the specific structure of displacement tooling 11, such as can be the electronic dress for being equipped with one or more guide railsIt sets, charging programmable device 14 and tested implantation equipment 15 can be individually positioned on two platforms that can be realized relative motion, soThe change in location between the two then may be implemented.What the charging programmable device 14 in the embodiment of the present invention was simulated is external charging device,Induction coil also is provided with inside charging programmable device 14.Relative position described in the present embodiment can be relative distance, while can also be withIncluding relative angle etc., it is specifically dependent upon the structure of displacement tooling 11.
Test board 16, which is equipped with, provides the element and the tested implantation equipment 15 of connection of load for tested implantation equipment 15Interface.Element on test board 16 for example may include the devices such as several relays, analog switch, resistance, these elements are usedTo simulate loading condition of the tested implantation equipment 15 when being actually implanted into human body.
Computer 13 is connect with test board 16, charging programmable device 14 and power supply 12 respectively, for controlling on test board 16Element provides load to tested implantation equipment 15, and the coil of control charging programmable device 14 passes through tested implantation 15 pairs of electricity of equipmentSource 12 (this power supply is battery simulator, is set as rechargeable battery during charging measurement) is charged, and passes through chargingProgrammable device 14 obtains the running parameter of tested implantation equipment 15.These running parameters can pass to through wireless communicationCharge programmable device 14.
During power supply 12 is electrically charged, displacement tooling 11 can change the coil of charging programmable device 14 and be tested implantationThe relative position of equipment 15, the change of the two distance or angle will affect the running parameter of tested implantation equipment 15, such as canTo include charging current, charging voltage, temperature etc..The coil of charging programmable device 14 will mode and tested implantation by wireless communicationEquipment 15 is communicated to read these parameters.For acquiring charging current, can be arranged between power supply 12 and test board 16Ammeter 17 measures charging current, and later computer 13 can set the data with the tested implantation spread out of by wireless communicationThe charging current of standby 15 included current sensors compares, these running parameters will be used to judge that tested implantation is set as test resultWhether standby 15 is qualified reliable.In non-charged state, i.e., tested implantation equipment 15 carries out the stage for the treatment of test, and ammeter 17 can be withReading for power supply power supply power consumption test data.
Test macro provided in an embodiment of the present invention utilizes charging programmable device mould using the battery of power supply simulation implantation equipmentQuasi- external charging device, and the loading condition using test board simulation implantation equipment in a state of use, make tested implantation equipmentUnder actual working environment, while changing charging programmable device coil using displacement tooling and being implanted into the relative position of equipment,The charging operations being likely to occur in actual use with analog subscriber are controlled charging process by computer and read implantationThe running parameter of equipment, the system carry out the stronger test of specific aim to the charging performance of implantation equipment, and entire test process is realExisting automatic operation, working efficiency with higher.
As a preferred embodiment, the computer 13 in the present embodiment can also read the work of charging programmable device 14Make parameter, and charge efficiency is calculated according to the running parameter of tested implantation equipment 15 and the running parameter of charging programmable device 14.It fillsThe voltage of the tested implantation equipment 15 of electrical efficiency=tested implantation equipment 15 charging current */(charging programmable device voltage * charging is compiledJourney device electric current).
The charging current and voltage of tested implantation equipment 15 and the programmable device 14 that charges can be respectively by its own sampling, chargingsEfficiency is sent to computer 13 after being calculated by charging programmable device 14.
Another embodiment of the present invention provides a kind of systems for detecting implantation medical instrument circuit board, in previous realityOn the basis of applying example, as shown in Fig. 2, being additionally provided with magnet 19 in the displacement tooling 11 of the present embodiment.Implantation equipment is typically provided with useIn the electromagnetic switch of reset, user can trigger this switch by magnet and realize corresponding control, the magnet 19 in the present embodimentThen it is used to detect the reset function of tested implantation equipment 15, computer 13 can control 11 variations in magnet 19 of displacement tooling and be testedIt is implanted into the relative position of equipment 15, and detects the working condition for the electromagnetic switch surveyed in tested implantation equipment 15.
In the present embodiment, displacement tooling 11 will control the change in location of two groups of devices, i.e. magnet 19 is set with tested implantationStandby 15 relative position, charging 14 coil of programmable device and the tested relative position for being implanted into equipment 15.For this purpose, displacement tooling 11 can be withTwo orthogonal guide rails are set, and wherein X-axis guide rail works as magnet for changing the relative position of magnet 19 and tested implantation equipment 1519 can be laterally accessible or far from tested implantation equipment 15 when moving along X-axis guide rail；Y-axis guide rail is for changing charging programmable deviceThe relative position of 14 coils and tested implantation equipment 15, can longitudinally approach when the programmable device 14 that charges is moved along Y-axis guide railOr far from tested implantation equipment 15.
In order to detect the performance of implantation equipment more fully hereinafter, the system of the present embodiment is also to the defeated of tested implantation equipment 15Signal is acquired out.Power supply 12 in the present embodiment is also used to charging programmable device 14, test board 16 and tested implantation equipment15 provide electric energy, so that the load board output waveform signals that tested implantation equipment 15 is provided according to test board 16, e.g. electric arteries and veinsSpurt energizing signal.
Correspondingly, this system further includes capture card 18, and the waveform signal exported for acquiring tested implantation equipment 15 calculatesMachine 13 obtains the waveform signal that tested implantation equipment 15 exports by capture card.
Computer 13 can also pass through the output parameter of the tested implantation equipment 15 of the charging setting of programmable device 14.Computer 13 is controlledSystem charging programmable device through wireless communication, is programmed tested implantation equipment 15, for example can be with according to testing requirementPulse output amplitude and the frequency etc. of tested implantation equipment 15 are set.
Test to output waveform, the test to charging process, can be successive with any order to the test of reset functionIt carries out, these detection operations do not conflict.
It will be understood by those skilled in the art that there are many type and model of the implantation equipment that manufacturer provides are also usual, exampleIf any brain pacemaker, spinal stimulator etc..In order to be able to detect detection system provided by the invention from different implantation equipmentCircuit board, as a preferred embodiment, the charging programmable device 14 in the present embodiment is also used to read tested implantation and setsStandby 15 intrinsic information, computer 13 can determine the signal for controlling the element on test board 16 according to the intrinsic information.ByThis can provide suitable load signal to the implantation equipment of different model, and this system is made to have preferable scalability.
The process of above-mentioned reading intrinsic information should carry out before detection starts, in conjunction with above-mentioned detection function, the present inventionEmbodiment also provides a kind of detection method, and this method is executed by above-mentioned computer 13, as shown in figure 3, this method includes following stepIt is rapid:
S1 obtains the intrinsic information of the tested implantation equipment 15 of implantation equipment by charging programmable device 14, which can be withIt is recorded in tested implantation equipment 15, also can recorde in charging programmable device 14, specifically can be type information, type informationEtc.；
S2A determines distance value and charge parameter according to intrinsic information, and what this distance value indicated is charging 14 coil of programmable deviceAt a distance between tested implantation equipment 15；Charge parameter for example can be charging current.It, can will be each before being testedIntrinsic information and its corresponding testing scheme (including distance value and charge parameter) are stored in computer 13, after detection startsWhen test board 16 is connect with tested implantation equipment 15, computer 13 can get intrinsic information, and inquire its corresponding surveyExamination scheme (including distance value and charge parameter).
Charge parameter is sent to charging programmable device 14 and tested implantation equipment 15 by S3A.Charge parameter in the present embodimentPower output parameter including the programmable device 14 that is suitable for charging and the electric energy suitable for tested implantation equipment 15 receive parameter.TheseCharge parameter can specify charging programmable device 14 for example with some or multiple charging currents output electric energy, can also correspondingly refer toFixed tested implantation equipment 15 switches suitable resistance parameter to adapt to the size of the charging current.As described above, computer 13 connectsWhat is connect is test board 16, which can pass to tested implantation equipment 15 by test board 16.
S4A, between coil and tested implantation equipment 15 that the adjustment charging programmable device 14 of Mobile tool 11 is controlled according to distance valueDistance, power supply 12 is arranged to be electrically charged state by computer 13, and controls charging programmable device 14 and pass through tested implantation equipment 15It is charged based on charge parameter to 12 inlet wire of power supply.This step can be there are many specific embodiment, such as above-mentioned distance value can be withSetting is one or more, both can also make fixed or multiple and different apart from upper carry out wireless charging at one；EachIt is a apart from upper, one or more also can be set in corresponding charge parameter, flexibly comprehensively detects according to product and user demandCharging effect.
S5A receives the running parameter that tested implantation equipment 15 is fed back according to charge parameter, can specifically pass through test board 16Read the running parameter that the sensor in tested implantation equipment 15 is recorded, for example, may include charging voltage, charging current,Temperature value etc.；
S6A judges whether tested implantation equipment 15 is normal according to running parameter, such as can judge that tested implantation is set respectivelyWhether standby 15 charging voltage, charging current, temperature value etc. meets expection, so that it is determined that whether its state is normal.
Detection method provided in an embodiment of the present invention determines phase by obtaining the intrinsic information of tested implantation equipment automaticallyThe test parameter answered sends suitable charge parameter to charging programmable device and tested implantation equipment, is in tested implantation equipmentUnder actual working environment, while changing using displacement tooling the coil of charging programmable device and the opposite position of tested implantation equipmentIt sets, the charging operations being likely to occur in actual use with analog subscriber, this method controls charging process simultaneously by computerThe running parameter of tested implantation equipment is read, the stronger detection of specific aim is carried out to implantation equipment with this, which realizesAutomatic operation, working efficiency with higher.
In order to improve convenience and accuracy, above-mentioned intrinsic information is preferably stored in tested implantation equipment 15, above-mentioned stepRapid S1 can specifically include following steps:
S11 sends enabling signal to charging programmable device 14, and programmable device 14 to be charged is waited to carry out with tested implantation equipment 15Communication is to obtain intrinsic information.
S12 receives the intrinsic information that charging programmable device 14 is fed back.
Enabling signal can be simple digital signal, and charging programmable device 14 can be by wireless after receiving enabling signalMode sends handshake to tested implantation equipment 15, which can be a waveform signal；Tested implantation equipment 15 can be withIt parses the handshake and is responded, intrinsic information is sent to charging programmable device 14, then re-sends to computer 13.
As a preferred embodiment, the charge parameter in the present embodiment includes charging time and charging current,In each distance value respectively correspond identical charging time and multiple charging currents.Such as four distance value X1 ... can be presetX4, charging time t, charging current A1 ... A4, these parameters can form multiple combinations, and S4A may include steps of:
S4A1, control Mobile tool 11 will charge and be separately positioned on each distance between programmable device 14 and tested implantation equipment 15It is upper to stop the corresponding charging time；
S4A2, when stopping, control charging programmable device 14 distinguishes base by tested implantation equipment 15 and tested implantation equipment 15It charges in multiple charging currents to power supply 12.
Such as can be in X1 apart from upper stop at least 4*t (four length identical period), and divide in each periodNot Cai Yong A1 ... A4 charge, thus complete the corresponding charging action of X1；Then distance is adjusted to X2, equally stops fourA length identical period, and A1 is respectively adopted in each period ... A4 charges, and uses later in X3, X4 distanceIdentical mode of operation, the corresponding charging action of X4 that X1 can be completed ....
S5A is carried out with S4A is synchronous, and computer 13 acquires the work ginseng that implantation equipment 15 is tested in above-mentioned charging process in real timeNumber, it is hereby achieved that four groups of parameters, i.e. running parameter corresponding to four kinds of different distances, wherein include again in every group of parameter withThe corresponding running parameter of four charging currents.
Above-mentioned preferred detection scheme can be detected accurately under different distance, be tested implantation equipment under different charge parametersWorking condition, thus improve the reliability of testing result.
Can also include: after above-mentioned steps S1 to further increase reliability and the convenience of detection operation
S1A determines criteria parameter according to intrinsic information, this step synchronous with S2A can carry out.Criteria parameter therein is answeredIt when corresponding with running parameter collected in step S5A, such as may include standard charge voltage, standard charging current, temperatureSpend upper limit value etc..
In the case where that can obtain criteria parameter, step S6A be may include steps of:
Running parameter is compared S6A1 with criteria parameter；
S6A2 judges whether tested implantation equipment 15 is normal according to comparison result, such as judges that running parameter and criterion are joinedWhether whether normally whether within the acceptable range consistent or the two error, be implanted into equipment 15 so that it is determined that being tested to number.
The detection operation of output waveform is introduced below.After step S1, computer 13 can control charging and compileMode is configured tested implantation equipment 15 to journey device 14 by wireless communication, such as its output amplitude and frequency can be setDeng the subsequent detection process for carrying out output signal, specifically, as shown in figure 4, this method can also include the following steps:
S2B determines that load parameter and power supply parameter, load parameter and power supply parameter are also possible to test according to intrinsic informationA part of content of scheme, the step for can it is synchronous with above-mentioned steps S2A carry out.The load of the product of each type or modelParameter and power supply parameter are not quite similar, and load parameter is, for example, nerve stimulator 1k resistance, 500 ohm of electricity of spinal stimulatorResistance；Power supply parameter is, for example, supply voltage etc..
S3B controls power supply 12 according to power supply parameter and powers to tested implantation equipment 15, and power supply 12 is arranged to by computer 13Energy state is exported, powers tested implantation equipment 15 to simulate actual working state；
S4B sends load parameter to the test board 16 of the tested implantation equipment 15 of connection, and test board 16 receives basisLoad parameter adjusts the element state of itself to simulate the load of tested implantation equipment 15, joins tested implantation equipment 15 in loadOutput waveform signals under the influence of number；
S5B obtains the waveform signal that tested implantation equipment 15 exports by capture card 18；
S6B judges whether tested implantation equipment 15 is normal according to waveform signal.
Above-mentioned steps S3B-S6B is not interfere with each other with step S3A-S6A isolated execution, and this method is to tested implantation equipment 15Output signal is automatically detected, and the comprehensive and convenience of detection operation is further increased.
Judgement for output waveform similarly with step S1A can also include: after step S1
S1B determines criterion signal according to intrinsic information；
Step S6B may include: in the case
Waveform signal is compared S6B1 with criterion signal；
S6B2 judges whether tested implantation equipment 15 is normal, and there are many concrete modes of signal fusing according to comparison result,The present invention repeats no more.
In addition to the detection of charge function and output signal, the step of tested implantation 15 reset function of equipment of detection can also be addedSuddenly, this step carries out in the state of guaranteeing that power supply 12 is in and is powered for tested implantation equipment 15, and the control of computer 13 movesIt starts building to fill the magnet on 11 and whether examines tested implantation equipment 15 close to tested implantation equipment 15, while by charging programmable device 14Be reset (various parameters recovery initial value).
The embodiment of the invention provides a kind of computer equipments, comprising: at least one processor；And at least oneManage the memory of device communication connection；Wherein, memory is stored with the computer program that can be executed by least one processor, calculatesMachine program is executed by least one processor, so that at least one processor executes above-mentioned implantation medical instrument circuit board detecting sideMethod.
Correspondingly, the embodiment of the invention provides a kind of circuits suitable for implantable medical equipment complete automatic test systemPlate, as above-mentioned test board 16, test board 16 as shown in Figure 5 includes:
Tested implantation apparatus connecting unit 161, for connecting each output electrode of tested implantation equipment 15, tested implantation is setThere are many concrete forms of standby interconnecting piece 161, and the purpose is to be electrically connected with output electrode holding.
Load unit 163, for simulating the load of tested implantation equipment.Implantation equipment will bear certain in human bodyThe load of the implantation equipment of load, variety classes and purposes is not identical, and a variety of load elements can be set to simulate not in this elementWith the load that tested implantation equipment 15 is born, such as there can be nerve stimulator 1k resistance, spinal stimulator is with 500 ohmResistance etc..
Selecting unit 164 and acquisition apparatus connecting unit 165.It acquires apparatus connecting unit 165 and quilt is connected by selecting unit 164Survey implantation apparatus connecting unit 161.Wherein the effect of selecting unit 164 is that control acquisition apparatus connecting unit 165 is connected to it defeatedThe connected relation of electrode out, while acquiring apparatus connecting unit 165 and connecting external acquisition equipment, i.e. capture card 18, capture card 18 canTo obtain the signal that be connected to electrode issues under load effect.
In actual conditions, tested implantation equipment 15 generally includes more output electrode, such as brain pacemaker may haveMore than ten output electrodes, each output electrode can individually issue stimulus signal.In order to accurately be detected, program is detectedOnly meeting control section output electrode signal may be issued in the same time, correspondingly, acquisition apparatus connecting unit 165 can pass through choosingIt selects unit 164 and connects all output electrodes, and same selection of time unit 164 can be connected only wherein just in output signalPartial electrode.
The implantation medical instrument detection circuit board provided according to embodiments of the present invention, can be by tested plant by the circuit boardEnter equipment and external detection equipment connects, and tested implantation equipment simulating actual working state is made by load unit, togetherShi Liyong selecting unit controls the connected state of external equipment and output electrode, to obtain the letter that tested implantation equipment issuesNumber, thus which can improve detection effect by carrying out flexible setting to selecting unit, to adapt to different detection demandsRate.
As a preferred embodiment, as shown in fig. 6, selecting unit 164 includes multiple analog switches, analog switchThe tested implantation corresponding output electrode of equipment (including metal shell) of connection correspondingly respectively, passes through the disconnection of analog switchWith the connected relation of closed state control output electrode and acquisition apparatus connecting unit 165.Acquisition apparatus connecting unit 165 is adopted to outsideThe waveform signal that collection equipment output electrode issues under load effect.
In the present embodiment, selecting unit 164 is set there are two switching group, and acquisition apparatus connecting unit 165 is equipped with correspondingTwo access interface Out1 and Out2, each access interface pass through the defeated of the different tested implantation equipment 15 of switching group connection respectivelyElectrode (including metal shell) out.In the present embodiment, one end of port Out1 connection first switch group 1641, first switch group1641 other end connects whole output electrodes and metal shell；One end of port Out2 connection second switch group 1642, secondThe other end of switching group 1642 connects whole output electrodes and metal shell.
Acquire two port Out1 and Out2 of apparatus connecting unit 165 and the whole output electrodes and gold of tested implantation equipmentAny two belonged in shell are connected.The state of first switch group 1641 and second switch group 1642 can be carried out by single-chip microcontrollerControl.Specifically, any two output electrode, by with computer connecting interface, serial port chip and single-chip microcontroller, by computerAccording to testing requirement, the control to analog switch is corresponded in first switch group 1641 and second switch group 1642 is realized, thus realThe connection of existing capture card and electrode output.
In practical application, in order to acquire the output signal of more multichannel simultaneously, more access interface and more also can be setMore switching groups.
In a preferred embodiment, load unit 163 may include:
Multiple groups load elements 1631 are respectively used to the load of simulation variety classes implantation equipment；
Multiple analog switches, these analog switches form third switching group 1632, for controlling multiple groups load elements 1631With the connection status of acquisition apparatus connecting unit 165 and output electrode.Two port Out1 and Out2 are connected with the both ends of loadIt connects.By realizing and being switched to third by computer according to testing requirement with computer connecting interface, serial port chip and single-chip microcontrollerThe control of analog switch is corresponded in group 1632, to realize the connection of two port Out1 and Out2 and different loads.It is optional negativeCarrying includes DBS (deep brain stimulation, deep brain stimulation), (vagusneve stimulation is confused absent-minded VNSThrough stimulating), SCS (Spinal cord stimulation, spinal cord stimulation trial) and SNM (Sacral Neuromodulation,Sacral nerve stimulation) load etc..
The load for being achieved in different product classification is connected with any two output electrode, while tested implantation equipment 15 is defeatedWaveform is connected to port Out1 and Out2 out, feeds back to capture card 18 and is handled.
About the power supply of test board 16 and the acquisition of charging current, power supply 12 and ammeter 17 can be connected to test board16.Power supply 12 can provide duplex feeding, is variable power voltage supply 10 (range is 4.1V~2V) all the way, simulates electricity using batterySource (charge prepd does charge function test) is that tested implantation equipment 15 is powered；Another way is constant voltage, passes through voltage chipsTo the electrical component power supply on test board 16.
About tested implantation apparatus connecting unit 161, the present invention provides two kinds of optional embodiments.
As the first embodiment, as shown in fig. 7, tested implantation apparatus connecting unit 161 includes contact switching device1611, finger plug 1612 and golden finger socket 1613.Contact switching device 1611 is fixedly connected with finger plug 1612,Such as it can be wholely set；Pluggable connection between finger plug 1612 and golden finger socket 1613.Wherein
Contact switching device 1611 is equipped with multiple metal clips, for being separately connected each output electricity of tested implantation equipmentPole.Such as having 8 output electrodes on an output cable of tested implantation equipment, then contact switching device 1611 is correspondingly arranged8 groups of metal clips keep status of electrically connecting with these electrodes；
Finger plug 1612 is equipped with multiple metal contact pieces, is connected respectively the metal elastic of contact switching device 1611Piece, such as can be electrically connected by conducting wire；
Golden finger socket 1613 is fixed in circuit board body 160, is used for grafting finger plug 1612, and pass through conducting wireConnect selecting unit 164.
Golden finger socket is arranged in above embodiment in circuit board body, passes through finger plug and contact switching deviceConnection realizes the connection to tested implantation equipment output electrode with this, and golden finger socket not only can connect tested implantation equipmentComplete machine, can be also used for the core circuit plate for connecting tested implantation equipment, and which makes test board itself have certain lead toWith property, different testing requirements can satisfy.
As second of embodiment, as shown in figure 8, tested implantation apparatus connecting unit 161 includes:
Contact switching device 1611, the difference is that, which is directly fixed on circuit with former embodimentOn plate ontology 160.Its metal clips is separately connected each output electrode of tested implantation equipment, and is directly connected and selected by conducting wireSelect unit 164.
Relative to former embodiment, above embodiment structure is simple, and specific aim is stronger, can be exclusively used in meeting quiltSurvey the testing requirement of implantation equipment complete machine.
About contact switching device 1611, the embodiment of the present invention provides a kind of preferred structure, as shown in figure 9, the deviceThe shell 16110 of groove 16111 is equipped with including one.In the present embodiment, being tested implantation equipment has two groups of output electrodes, thereforeThe device is correspondingly provided with two grooves 16111, and metal clips 16112 is arranged in pairs in groove 16111, metal clips pair with16111 bottom of groove can clamp the output cable 151 of tested implantation equipment.Itself has certain bullet between metal clips pairProperty, combines with housing bottom, the structure can play be fixedly secured and convenient for plug effect.
Multiple output electrodes of tested implantation equipment are equably arranged in the end of output cable 151, correspondingly this implementationNumber of electrodes in groove 16111 in example on the single output cable 151 of the quantity of metal clips pair and tested implantation equipmentIt is identical.151 end of output cable of tested implantation equipment in the present embodiment as shown in Figure 9 is equipped with 8 output electrodes, and two recessed8 pairs of metal clips 16112 are respectively equipped in slot 16111.151 end of length and output cable of groove 16111 in the present embodimentThe length of end arrangement output electrode is consistent, and only is suitable for accommodating the end of output cable 151, when output cable 151 is inserted into grooveWhen in 16111,151 end of cable can be made to contact 16111 side bottom of groove, at the same make each metal clips to just withEach output electrode is in contact.
In said structure, the groove length of contact switching device is consistent with output cable end electrodes spread length, andAnd the clamping of the output cable of tested implantation equipment is accepted and a little is only that on metal electrode, the structure be convenient for tester intoRow operation, and can play the role of protecting output cable.
Particular embodiments described above has carried out further in detail the purpose of the present invention, technical scheme and beneficial effectsDescribe in detail it is bright, it should be understood that the above is only a specific embodiment of the present invention, the guarantor being not intended to limit the present inventionRange is protected, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should be included in thisWithin the protection scope of invention.