技术领域technical field
本发明涉及一种儿童变径球囊扩张导管，是儿童静脉血管成形专用的介入手术器材，属于医疗器械领域。The invention relates to a variable-diameter balloon dilatation catheter for children, which is special interventional operation equipment for children's venous angioplasty, and belongs to the field of medical equipment.
背景技术Background technique
儿童肝移植是解决儿童终末期肝病的首选治疗手段。儿童肝移植的预后受多种因素影响，其中最重要的是并发症的防治。静脉狭窄是儿童肝移植术后常见血管并发症，若不及时有效治疗，致死率可达24％。肝移植术后儿童血管并发症发生率显著高于成人，临床上有大量存在儿童肝移植术后静脉狭窄的患儿被检出。但目前并无有效解决移植术后静脉狭窄的治疗方法。Pediatric liver transplantation is the preferred treatment for children with end-stage liver disease. The prognosis of liver transplantation in children is affected by many factors, the most important of which is the prevention and treatment of complications. Venous stenosis is a common vascular complication after liver transplantation in children. If it is not treated in time and effectively, the fatality rate can reach 24%. The incidence of vascular complications in children after liver transplantation is significantly higher than that in adults, and a large number of children with venous stenosis after liver transplantation in children have been detected clinically. However, there is currently no effective treatment for vein stenosis after transplantation.
目前临床上广泛应用的血管支架成形术均采用不变径的筒型支架。有研究报道，使用血管支架成形术治疗儿童肝移植术后门静脉狭窄的技术成功率为66.7％，临床治疗成功率为73.0％，但是五年长期通畅率未知。解剖学和临床已经证实，肝移植供体与受体门静脉的直径差异，是儿童肝移植术后发生门静脉狭窄以及影响支架成形术临床治疗成功率的重要因素。由于筒型非变径支架无法同时兼顾受体与供体的直径，低龄患儿血管直径随生长发育而增宽，植入圆筒非变径状支架可能引起近心端贴壁不良，远端过度扩张，以上均会引起血管损伤、内膜增生，增加支架内再狭窄甚至门静脉血栓的发生率。因此筒型非变径支架置入患儿血管中后常不能保证患儿门静脉长期通畅，影响术后临床治疗成功率。At present, the widely used vascular stent angioplasty in clinic all adopts the cylindrical stent with constant diameter. Studies have reported that the technical success rate of portal vein stenosis after liver transplantation in children using stent angioplasty is 66.7%, and the clinical treatment success rate is 73.0%, but the five-year long-term patency rate is unknown. Anatomical and clinical studies have confirmed that the difference in portal vein diameter between liver transplantation donors and recipients is an important factor for portal vein stenosis after liver transplantation in children and affects the clinical success rate of stenting. Since the diameter of the cylindrical non-reducing stent cannot take into account the diameters of the recipient and the donor at the same time, the diameter of blood vessels in young children increases with growth and development. Excessive expansion, all of the above will cause vascular injury, intimal hyperplasia, increase the incidence of in-stent restenosis and even portal vein thrombosis. Therefore, the long-term patency of the portal vein cannot be guaranteed after the cylindrical non-reducing stent is placed in the blood vessel of the child, which affects the success rate of postoperative clinical treatment.
本申请人发明了一种儿童变径球囊扩张式血管支架，中国专利申请号为201711470561.8。该用于儿童肝移植术后门静脉狭窄的支架，支架主体由沿轴向分布的多个环状支撑件构成，相邻的两个环状支撑件通过至少一个连接件连接；支架主体分为三部分，依次为近心端部、中端部和远心端部，中端部的管径最小，近心端部的管径最大；中端部与其两侧的近心端部和远心端部分别以斜肩自然过渡连接。现有技术中缺少与该儿童变径球囊扩张式血管支架的结构相匹配的球囊扩张导管，导致该儿童变径球囊扩张式血管支架无法被应用。The applicant invented a children's variable-diameter balloon-expandable vascular stent, and the Chinese patent application number is 201711470561.8. In the stent for portal vein stenosis after liver transplantation in children, the stent body is composed of a plurality of ring-shaped supports distributed along the axial direction, and two adjacent ring-shaped supports are connected by at least one connecting piece; the stent body is divided into three parts. The proximal end, the middle end, and the distal end in turn, the diameter of the middle end is the smallest, and the diameter of the proximal end is the largest; the middle end and the proximal end and the distal end on both sides The parts are connected with a natural transition of oblique shoulders. The prior art lacks a balloon expansion catheter matching the structure of the children's variable-diameter balloon-expandable vascular stent, so that the children's variable-diameter balloon-expandable vascular stent cannot be applied.
发明内容Contents of the invention
有鉴于此，本申请实施例提供一种儿童变径球囊扩张导管，在球囊部位设置具有多个变径区域的球囊，以实现与儿童肝移植术后门静脉位置生理结构的匹配，配合支架进行病变血管的预扩和后扩，对于简单狭窄的病变也可进行单纯球囊扩张进行治疗，配合儿童变径球囊扩张式血管支架进行释放。In view of this, the embodiment of the present application provides a variable-diameter balloon dilatation catheter for children. A balloon with multiple variable-diameter regions is provided at the balloon site to match the physiological structure of the portal vein after liver transplantation in children. The stent performs pre-expansion and post-expansion of the diseased blood vessel. For simple stenotic lesions, simple balloon dilation can also be used for treatment, and children's variable-diameter balloon-expandable vascular stent can be released.
为实现上述目的，本申请实施例提供的技术方案如下：In order to achieve the above purpose, the technical solutions provided by the embodiments of the present application are as follows:
一种儿童变径球囊扩张导管，包括：外管、球囊、内管和连接件，其中：A children's variable-diameter balloon dilatation catheter, comprising: an outer tube, a balloon, an inner tube and a connecting piece, wherein:
所述外管为中空的圆柱状管体，外管的近端与连接件相固定，并且与连接件之间相密封，外管的远端与球囊的近端相密封固定；The outer tube is a hollow cylindrical tube, the proximal end of the outer tube is fixed to the connector, and is sealed with the connector, and the distal end of the outer tube is sealed and fixed to the proximal end of the balloon;
所述内管贯穿于所述外管的内腔中，所述内管的远端伸出所述外管的远端，并且所述内管的远端与所述球囊的远端相密封固定；The inner tube runs through the lumen of the outer tube, the distal end of the inner tube protrudes from the distal end of the outer tube, and the distal end of the inner tube is sealed with the distal end of the balloon fixed;
所述连接件固定在所述外管的近端，所述连接件上设置有第一接口和第二接口，并且所述第一接口与所述内管外表面和球囊内标表面之间的空间、所述内管外表面与外管内表面之间的空间相连通；所述第二接口与所述内管的近端开口相连通；The connecting piece is fixed on the proximal end of the outer tube, the connecting piece is provided with a first interface and a second interface, and the connection between the first interface and the outer surface of the inner tube and the internal standard surface of the balloon The space between the outer surface of the inner tube and the inner surface of the outer tube communicates; the second interface communicates with the proximal opening of the inner tube;
所述球囊为分段式管状腔体，具有横截面均为圆形的远端部分、中端部分和近端部分，其中该近端部分可膨胀至比该远端部分大的扩张直径，该远端部分可膨胀至比该中端部分大的扩张直径，所述球囊的远端部分、中端部分和近端部分均具有锥形过渡结构。The balloon is a segmented tubular cavity having a distal portion, a middle portion, and a proximal portion all of which are circular in cross-section, wherein the proximal portion is expandable to a larger expanded diameter than the distal portion, The distal portion is expandable to a larger expanded diameter than the middle portion, and the distal, middle, and proximal portions of the balloon all have tapered transition structures.
所述球囊的远端部分、中端部分和近端部分膨胀后的横截面均为圆形，远端部分圆形横截面的直径为6mm-12mm，适用于低龄儿童门静脉，中端部分圆形横截面的直径为5mm-10mm，适用于门静脉吻合口直径，近端部分圆形横截面的直径为10mm-16mm，适用于成人静脉，球囊的长度为10mm-70mm。支架整体呈变径圆筒状，远端部分的直径小于近端部分的直径，二者直径相差2-6毫米，中端部分为最小直径，与远端部分、近端部分相差4-6毫米。The inflated distal part, middle part and proximal part of the balloon have a circular cross-section, the diameter of the circular cross-section of the distal part is 6mm-12mm, which is suitable for the portal vein of young children, and the middle part is round The diameter of the circular cross-section is 5mm-10mm, which is suitable for the diameter of portal vein anastomosis, the diameter of the circular cross-section of the proximal part is 10mm-16mm, which is suitable for adult veins, and the length of the balloon is 10mm-70mm. The overall shape of the stent is cylindrical with variable diameter, the diameter of the distal part is smaller than the diameter of the proximal part, the difference between the two diameters is 2-6 mm, the middle part is the smallest diameter, and the difference between the distal part and the proximal part is 4-6 mm .
所述球囊的长度优选为20mm-40mm，其中远端部分的长度为7mm-10mm，中端部分的长度为6mm-8mm，近端部分的长度为10mm-15mm，锥形过渡结构的长度为2mm-4mm。每一个部分的锥形过渡结构的长度可以是相等的，锥形的夹角为常规度数。The length of the balloon is preferably 20mm-40mm, wherein the length of the distal part is 7mm-10mm, the length of the middle part is 6mm-8mm, the length of the proximal part is 10mm-15mm, and the length of the tapered transition structure is 2mm-4mm. The length of the tapered transition structure of each part may be equal, and the included angle of the tapered shape is a conventional degree.
优选的，该球囊扩张导管进一步包括：至少一个显影标记，至少一个所述显影标记嵌在或套设在所述内管上，并且显影标记的位置与所述球囊的位置相对应。显影标记采用不透X射线的铂金或具有显影特性的材料制造。Preferably, the balloon dilation catheter further includes: at least one visible mark, at least one visible mark is embedded or sleeved on the inner tube, and the position of the visible mark corresponds to the position of the balloon. Developable markers are manufactured from X-ray opaque platinum or materials with developing properties.
优选的，该球囊扩张导管进一步包括：应力扩散管，应力扩散管固定在外管与连接件之间或包覆在外管与连接件的连接处，其作用是增加外管近端与连接件之间的强度。Preferably, the balloon dilation catheter further includes: a stress diffusion tube, the stress diffusion tube is fixed between the outer tube and the connector or coated at the connection between the outer tube and the connector, and its function is to increase the stress between the proximal end of the outer tube and the connector. Strength of.
所述球囊的材料为尼龙类聚合物、生物可降解聚合物、天然纤维材料或其混合物。The material of the balloon is nylon polymer, biodegradable polymer, natural fiber material or a mixture thereof.
所述球囊的外表面涂有亲水涂层，所述亲水涂层带有羧酸基、磺酸基、硫酸及、氨基、季氨基和醚基官能团中的一种或几种。The outer surface of the balloon is coated with a hydrophilic coating, and the hydrophilic coating has one or more functional groups of carboxylic acid group, sulfonic acid group, sulfuric acid group, amino group, quaternary amino group and ether group.
本发明的球囊采用变径设计，球囊工作段有3段不同直径的球囊管体，采用一体成型制作。球囊的整体结构为中端部分的直径最小，近端部分的直径较远端部分的直径大，远端部分的直径较中端部分的直径大，即近端部分具有最大的直径。采用这样的结构设计，可以与儿童变径球囊扩张式血管支架(中国专利申请号为201711470561.8)的形状、构造完全匹配，将支架固定在球囊外部，在体内相应部位进行释放。球囊采用横截面为圆形的结构可适应静脉系统解剖结构，贴壁性更好并因此可以避免进行扩张手术时将静脉远心端病变血管的远端扩张过渡而近心端静脉近端扩张不足而影响扩张手术效果，降低术后的血栓或再狭窄发生的可能性。The balloon of the present invention adopts a diameter-variable design, and the working section of the balloon has three sections of balloon tubes with different diameters, which are manufactured by integral molding. The overall structure of the balloon is that the diameter of the middle part is the smallest, the diameter of the proximal part is larger than that of the distal part, and the diameter of the distal part is larger than that of the middle part, that is, the proximal part has the largest diameter. With such a structural design, it can completely match the shape and structure of the children's variable-diameter balloon-expandable vascular stent (Chinese patent application number 201711470561.8), fix the stent outside the balloon, and release it in the corresponding part of the body. The balloon adopts a circular structure in cross section, which can adapt to the anatomical structure of the venous system, and has better wall-attachment, so it can avoid the expansion of the distal end of the diseased blood vessel at the distal end of the vein and the expansion of the proximal end of the vein during dilation surgery. If it is insufficient, it will affect the effect of dilation surgery and reduce the possibility of postoperative thrombus or restenosis.
释放阶段：介入手术时，经皮门静脉穿刺，留置鞘管将导丝插入门静脉内，沿导丝插入支架输送鞘管至门静脉远心端处，退出输送和回收鞘管内芯和导丝，经输送和回收鞘送入血管内支架至鞘管远心端处，根据预先定位标志，将血管内支架前1/2定位于供体门静脉内，后1/2位于受体门静脉内，中端部置入于门静脉吻合口处，使用本发明的球囊扩张导管将支架释放于血管吻合口处。Release stage: During interventional surgery, the portal vein is punctured percutaneously, the guide wire is inserted into the portal vein with the indwelling sheath, and the stent is inserted along the guide wire to deliver the sheath to the distal end of the portal vein. and the recovered sheath into the endovascular stent to the distal end of the sheath. According to the pre-positioning marks, the front 1/2 of the endovascular stent is positioned in the donor's portal vein, the rear 1/2 is positioned in the recipient's portal vein, and the middle end is placed in the portal vein of the recipient. Inserted at the anastomosis of the portal vein, the balloon expansion catheter of the present invention is used to release the stent at the anastomosis of the blood vessel.
本发明的优点是：可解决当前无法释放非标准球囊扩张式支架的问题，使儿童变径球囊扩张式支架释放更准确，并可针对特殊解剖形态的病变进行治疗。The invention has the advantages that it can solve the problem that the current non-standard balloon-expandable stent cannot be released, makes the release of the variable-diameter balloon-expandable stent more accurate for children, and can treat lesions with special anatomical forms.
附图说明Description of drawings
为了更清楚地说明本申请实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图做简单地介绍，显而易见地，下面描述中的附图仅仅是本申请中记载的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments described in this application. Those skilled in the art can also obtain other drawings based on these drawings without creative work.
图1本发明的实施例1结构示意图Fig. 1 Structural schematic diagram of Embodiment 1 of the present invention
图2为球囊部分的A-A剖面图Figure 2 is the A-A sectional view of the balloon part
具体实施方式Detailed ways
为了使本领域的人员更好地理解本申请中的技术方案，下面将结合本申请实施例中的附图，对本申请实施例中国的技术方案进行清楚、完整的描述，显然，所述的实施例仅仅是本申请的一部分实施例，而不是全部的实施例。基于本申请中国的实施例，本领域普通技术人员在没有做出创造性的劳动的前提下所获得的所有其他实施例，都应当属于本申请的保护范围。In order to enable those skilled in the art to better understand the technical solutions in this application, the technical solutions in the embodiments of this application will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of this application. Obviously, the described implementation Examples are only some of the embodiments of the present application, but not all of them. Based on the Chinese embodiments of the present application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present application.
本文中的“远端”是指在输送时靠近病人的一端，“近端”是指在临床操作时靠近操作人员的一端。The "distal end" herein refers to the end close to the patient during delivery, and the "proximal end" refers to the end close to the operator during clinical operation.
实施例1Example 1
图1为本申请提供的球囊扩张导管的一种具体实施方式的结构示意图。FIG. 1 is a schematic structural view of a specific embodiment of a balloon dilatation catheter provided by the present application.
如图1和图2所示，该球囊扩张导管包括：外管1、内管2、球囊3、连接件4、显影标记5、应力扩散管6。As shown in FIGS. 1 and 2 , the balloon dilatation catheter includes: an outer tube 1 , an inner tube 2 , a balloon 3 , a connecting piece 4 , a developing mark 5 , and a stress diffusion tube 6 .
外管1为中空的结构，外管1的近端与连接件4相固定，并且与连接件4之间相密封，外管1的远端与球囊3的一端相密封固定。另外，为了保证外管1远端足够柔软可以进入血管，并且保证外管1的近端足够硬，以便在推送时可以提供较大的推力，在本申请其他实施例中，外管1还可以采用多段式设计，即从外管1的远端至近端，构成外管1的各段材料的硬度逐渐增加，例如位于外管1远端部分的段的材料可以选择材质较软的聚酰胺高分子材料、改性聚酰胺高分子材料或聚酰胺类高分子复合材料，而位于外管1近端部分的各段的材料可以选择材质相对较硬的尼龙或尼龙的混合物。The outer tube 1 is a hollow structure, the proximal end of the outer tube 1 is fixed with the connecting piece 4 and is sealed with the connecting piece 4 , and the distal end of the outer tube 1 is sealed and fixed with one end of the balloon 3 . In addition, in order to ensure that the distal end of the outer tube 1 is soft enough to enter blood vessels, and that the proximal end of the outer tube 1 is hard enough to provide a greater thrust when pushing, in other embodiments of the present application, the outer tube 1 can also be A multi-stage design is adopted, that is, from the far end to the proximal end of the outer tube 1, the hardness of each section of the outer tube 1 gradually increases. For example, the material of the section located at the distal part of the outer tube 1 can be soft polyamide Polymer material, modified polyamide polymer material or polyamide polymer composite material, and the material of each segment located at the proximal part of the outer tube 1 can be relatively hard nylon or a mixture of nylon.
球囊3为分段式管状腔体，具有膨胀后横截面均为圆形的远端部分31、中端部分32和近端部分33，其中该近端部分33可膨胀至比该远端部分31大的扩张直径，该远端部分31可膨胀至比该中端部分32大的扩张直径，所述球囊3的远端部分31、中端部分32和近端部分33均具有锥形过渡结构34。远端部分31圆形横截面的直径为12mm，长度为10mm；中端部分32的圆形横截面的直径为10mm，长度为8mm；近端部分33的圆形横截面的直径为16mm，长度为15mm。各部分的锥形过渡结构34的长度为2mm-4mm。The balloon 3 is a segmented tubular cavity, having a distal portion 31, a middle portion 32 and a proximal portion 33 that are circular in cross-section after expansion, wherein the proximal portion 33 can be expanded to be larger than the distal portion. 31 large expansion diameter, the distal portion 31 can be expanded to a larger expansion diameter than the middle portion 32, the distal portion 31, the middle portion 32 and the proximal portion 33 of the balloon 3 all have a tapered transition structure34. The diameter of the circular cross-section of the distal part 31 is 12 mm, and the length is 10 mm; the diameter of the circular cross-section of the middle part 32 is 10 mm, and the length is 8 mm; the diameter of the circular cross-section of the proximal part 33 is 16 mm, and the length is 10 mm. 15mm. The length of the tapered transition structure 34 of each part is 2mm-4mm.
球囊3通过热焊接、激光焊接或其他方式密封固定在外管1的远端，并且在焊接部位形成密封。球囊3的材料可以为医用高分子材料，例如聚酰胺类高分子材料、改性聚酰高分子材料或高分子复合材料。此外，为了能够顺利地对血管进行扩张，球囊3能够承受的爆破压力选择在6-30atm范围内。The balloon 3 is sealed and fixed on the distal end of the outer tube 1 by heat welding, laser welding or other means, and a seal is formed at the welding site. The material of the balloon 3 can be a medical polymer material, such as a polyamide polymer material, a modified polyamide polymer material or a polymer composite material. In addition, in order to expand the blood vessel smoothly, the burst pressure that the balloon 3 can withstand is selected within the range of 6-30 atm.
内管2贯穿于外管1的内腔中，内管2的远端伸出外管1的远端开口，并且内管2的远端与球囊3的远端相密封固定，内管2与球囊3同样可以通过热焊接或激光焊接的方式固定，焊接处密封。The inner tube 2 runs through the inner cavity of the outer tube 1, the distal end of the inner tube 2 protrudes from the distal opening of the outer tube 1, and the distal end of the inner tube 2 is sealed and fixed with the distal end of the balloon 3, and the inner tube 2 and the distal end of the balloon 3 are sealed and fixed. The balloon 3 can also be fixed by heat welding or laser welding, and the welding place is sealed.
如图1所示，连接件4固定在外管1的近端，在连接件4上设置两连个接口：第一接口41和第二接口42，其中：第一接口41与内管2外表面和球囊3内表面之间的空间、内管2外表面与外管1内表面之间的空间相连通，在手术过程中，当将球囊3输送到位后，可以向第一接口41内注入液体或气体，使球囊3在压力的作用下扩张，将病变处狭窄的血管扩张；所述第二接口42与内管2的近端开口相连通，在手术时，可以先将导丝前端穿入到血管内，然后从内管2的远端开口将导丝末端穿入，并由第二接口42穿出，这样可以在导丝的引导下，将该球囊扩张导管输送到位。As shown in Figure 1, the connector 4 is fixed on the proximal end of the outer tube 1, and two interfaces are arranged on the connector 4: a first interface 41 and a second interface 42, wherein: the first interface 41 and the outer surface of the inner tube 2 It communicates with the space between the inner surface of the balloon 3 and the space between the outer surface of the inner tube 2 and the inner surface of the outer tube 1. During the operation, when the balloon 3 is delivered in place, it can be inserted into the first interface 41 Inject liquid or gas to expand the balloon 3 under the action of pressure to dilate the narrow blood vessels at the lesion; the second interface 42 is connected with the proximal opening of the inner tube 2, and the guide wire can be inserted first during the operation. The front end is inserted into the blood vessel, and then the end of the guide wire is inserted through the distal opening of the inner tube 2, and passed out through the second interface 42, so that the balloon dilatation catheter can be delivered to the position under the guidance of the guide wire.
该球囊扩张导管还包括：至少一个显影标记5，显影标记5嵌在或套设在内管2上，其位置与球囊3的位置相对应，用于推送时显示球囊3的位置。在本申请实施例中，显影标记5的个数为2个，并且两个显影标记分别设置于球囊3两端相对内管2上。The balloon dilatation catheter also includes: at least one visualization mark 5, which is embedded or sheathed on the inner tube 2, and its position corresponds to the position of the balloon 3, and is used to display the position of the balloon 3 when pushed. In the embodiment of the present application, the number of developing marks 5 is two, and the two developing marks are respectively arranged on the two ends of the balloon 3 opposite to the inner tube 2 .
该球囊扩张导管还包括：应力扩散管6，应力扩散管6固定在外管1与连接件4之间或包覆在外管1与连接件4的连接处，其作用是增加外管1近端与连接件4之间的强度。The balloon dilation catheter also includes: a stress diffusion tube 6, the stress diffusion tube 6 is fixed between the outer tube 1 and the connector 4 or coated at the junction of the outer tube 1 and the connector 4, and its function is to increase the distance between the proximal end of the outer tube 1 and the connector 4. Strength between connectors 4.
实施例2.Example 2.
与实施例1的区别在于，球囊3为分段式管状腔体，具有膨胀后横截面均为圆形的远端部分31、中端部分32和近端部分33。远端部分31圆形横截面的直径为6mm，长度为7mm；中端部分32的圆形横截面的直径为5mm，长度为6mm；近端部分33的圆形横截面的直径为10mm，长度为10mm。各部分的锥形过渡结构34的长度为2mm。The difference from Embodiment 1 is that the balloon 3 is a segmented tubular cavity, which has a distal part 31 , a middle part 32 and a proximal part 33 all of which are circular in cross-section after inflation. The diameter of the circular cross-section of the distal part 31 is 6 mm, and the length is 7 mm; the diameter of the circular cross-section of the middle part 32 is 5 mm, and the length is 6 mm; the diameter of the circular cross-section of the proximal part 33 is 10 mm, and the length 10mm. The length of the tapered transition structure 34 in each section is 2 mm.
以上显示和描述了本发明的基本原理和主要特征及本发明的优点，本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内，本发明要求保护范围由所附的权利要求书及其等效物界定。Above shows and described basic principle of the present invention and main feature and the advantage of the present invention, those skilled in the art should understand that, the present invention is not limited by above-mentioned embodiment, what described in above-mentioned embodiment and description just illustrates the present invention Principle, under the premise of not departing from the spirit and scope of the present invention, the present invention also has various changes and improvements, and these changes and improvements all fall within the claimed scope of the present invention, and the claimed protection scope of the present invention is defined by the appended claims Requirements and their equivalents are defined.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810477321.9ACN108578879B (en) | 2018-05-17 | 2018-05-17 | Special catheter for children's reducing saccule dilating vascular stent |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810477321.9ACN108578879B (en) | 2018-05-17 | 2018-05-17 | Special catheter for children's reducing saccule dilating vascular stent |
| Publication Number | Publication Date |
|---|---|
| CN108578879Atrue CN108578879A (en) | 2018-09-28 |
| CN108578879B CN108578879B (en) | 2024-02-09 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810477321.9AActiveCN108578879B (en) | 2018-05-17 | 2018-05-17 | Special catheter for children's reducing saccule dilating vascular stent |
| Country | Link |
|---|---|
| CN (1) | CN108578879B (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109701140A (en)* | 2018-12-29 | 2019-05-03 | 先健科技(深圳)有限公司 | Foley's tube and its lancing system |
| CN111228634A (en)* | 2020-02-21 | 2020-06-05 | 玮铭医疗器械(上海)有限公司 | Adjustable sacculus pipe |
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6464718B1 (en)* | 1998-11-16 | 2002-10-15 | Cordis Corporation | Balloon catheter for stent delivery having microchannels and method |
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| CN102380156A (en)* | 2011-08-25 | 2012-03-21 | 微创医疗器械(上海)有限公司 | Sectional type balloon expanding catheter |
| CN102727136A (en)* | 2011-04-06 | 2012-10-17 | 乐金电子(天津)电器有限公司 | Rolling brush structure with spiral blades |
| CN103316417A (en)* | 2013-06-08 | 2013-09-25 | 周玉杰 | Cone-shaped balloon dilatation catheter |
| CN105771069A (en)* | 2016-05-27 | 2016-07-20 | 心凯诺医疗科技(上海)有限公司 | Novel balloon dilatation catheter |
| CN208741722U (en)* | 2018-05-17 | 2019-04-16 | 首都医科大学附属北京友谊医院 | A child variable diameter balloon dilatation catheter |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5755707A (en)* | 1995-08-04 | 1998-05-26 | Nissho Corporation | Vascular dilating catheter |
| US6464718B1 (en)* | 1998-11-16 | 2002-10-15 | Cordis Corporation | Balloon catheter for stent delivery having microchannels and method |
| CN201135683Y (en)* | 2007-11-07 | 2008-10-22 | 乐普（北京）医疗器械股份有限公司 | A tapered balloon dilatation catheter |
| CN102727136A (en)* | 2011-04-06 | 2012-10-17 | 乐金电子(天津)电器有限公司 | Rolling brush structure with spiral blades |
| CN102380156A (en)* | 2011-08-25 | 2012-03-21 | 微创医疗器械(上海)有限公司 | Sectional type balloon expanding catheter |
| CN103316417A (en)* | 2013-06-08 | 2013-09-25 | 周玉杰 | Cone-shaped balloon dilatation catheter |
| CN105771069A (en)* | 2016-05-27 | 2016-07-20 | 心凯诺医疗科技(上海)有限公司 | Novel balloon dilatation catheter |
| CN208741722U (en)* | 2018-05-17 | 2019-04-16 | 首都医科大学附属北京友谊医院 | A child variable diameter balloon dilatation catheter |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109701140A (en)* | 2018-12-29 | 2019-05-03 | 先健科技(深圳)有限公司 | Foley's tube and its lancing system |
| CN111228634A (en)* | 2020-02-21 | 2020-06-05 | 玮铭医疗器械(上海)有限公司 | Adjustable sacculus pipe |
| Publication number | Publication date |
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| CN108578879B (en) | 2024-02-09 |
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