技术领域technical field
本发明涉及生物化学领域，特别涉及POCT全自动化学发光免疫分析仪。The invention relates to the field of biochemistry, in particular to a POCT automatic chemiluminescence immunoassay analyzer.
背景技术Background technique
随着人们对于健康的日益重视，临床检验技术也进入了一个高速发展的时代，而化学发光仪作为临床检验机构的重要一员，现在基本上属于标配。一方面由于其测试项目的多样性，能胜任多种病症的检验、筛查，同时化学发光仪的精准的测量属性，能对临床诊断给出精确的判断依据。With people's increasing emphasis on health, clinical testing technology has also entered an era of rapid development, and chemiluminescence instruments, as an important member of clinical testing institutions, are now basically standard equipment. On the one hand, due to the diversity of its test items, it is capable of testing and screening a variety of diseases. At the same time, the precise measurement properties of the chemiluminescence instrument can provide accurate judgment basis for clinical diagnosis.
现有技术中的POCT全自动化学发光免疫分析仪，通常体积庞大，灵活性低，对于一些空间有限的科室，无法满足其使用需求，严重地影响了测试的及时性，有可能对临床产生一些负面的影响。The POCT automatic chemiluminescence immunoassay analyzer in the prior art is usually bulky and has low flexibility. For some departments with limited space, it cannot meet its use requirements, seriously affecting the timeliness of the test, and may have some clinical consequences. negative influence.
发明内容Contents of the invention
本发明的主要目的是提出一种POCT全自动化学发光免疫分析仪，旨在解决现有技术中POCT全自动化学发光免疫分析仪体积庞大，灵活性低，测试速度慢的问题。The main purpose of the present invention is to propose a POCT automatic chemiluminescence immunoassay analyzer, which aims to solve the problems of bulky volume, low flexibility and slow test speed in the prior art.
为实现上述目的，本发明提出的POCT全自动化学发光免疫分析仪，包括：机架、反应机构、清洗机构及与所述反应机构相对设置的试剂样本机构，所述反应机构与所述试剂样本机构均设置于所述机架上，所述反应机构为中空结构，所述清洗机构设置于所述反应机构的中空结构中，用于清洗所述反应机构中的反应杯。In order to achieve the above object, the POCT automatic chemiluminescence immunoassay analyzer proposed by the present invention includes: a frame, a reaction mechanism, a cleaning mechanism and a reagent sample mechanism arranged opposite to the reaction mechanism, the reaction mechanism and the reagent sample The mechanisms are all arranged on the frame, the reaction mechanism is a hollow structure, and the cleaning mechanism is arranged in the hollow structure of the reaction mechanism for cleaning the cuvettes in the reaction mechanism.
优选地，所述反应机构包括用于放置反应杯的反应盘、与所述反应盘连接的第一驱动件，所述反应盘转动设置于所述机架上，所述第一驱动件驱动所述反应盘转动以使所述反应杯转动至对应的加样位。Preferably, the reaction mechanism includes a reaction disk for placing reaction cups, and a first driving member connected with the reaction disk, the reaction disk is rotatably arranged on the frame, and the first driving member drives the The reaction disk is rotated so that the reaction cup is rotated to the corresponding sample adding position.
优选地，所述反应机构还包括用于混匀反应杯的第一混匀件，所述反应盘上设有开口，所述第一混匀件设置于所述开口处，所述反应盘将所述反应杯转动至所述开口处时使所述反应杯与所述第一混匀件抵接。Preferably, the reaction mechanism further includes a first mixing member for mixing the reaction cup, an opening is provided on the reaction disk, the first mixing member is arranged at the opening, and the reaction disk will When the cuvette rotates to the opening, the cuvette abuts against the first mixing member.
优选地，所述清洗机构包括升降件、第三驱动件、用于放置所述反应杯的转动盘、用于注入清洗剂的出水管及用于排水的排水管，所述转动盘设置于所述反应盘的中空结构中，所述第三驱动件驱动所述转动盘转动以使所述反应杯转动至清洗位，所述出水管与所述排水管设置于所述清洗位上方，并连接所述升降件，所述转动盘为中空结构，所述升降件设置于所述转动盘的中空结构中，所述升降件降下时使所述出水管与所述排水管伸入所述反应杯中，且所述排水管与所述反应杯的底壁相抵接。Preferably, the cleaning mechanism includes a lifting member, a third driving member, a rotating disk for placing the cuvette, an outlet pipe for injecting cleaning agent, and a drain pipe for draining water, and the rotating disk is arranged on the In the hollow structure of the reaction disk, the third driving member drives the rotation disk to rotate the reaction cup to the cleaning position, and the water outlet pipe and the drain pipe are arranged above the cleaning position and connected to The lifting member, the rotating disk is a hollow structure, the lifting member is arranged in the hollow structure of the rotating disk, when the lifting member is lowered, the outlet pipe and the drain pipe extend into the cuvette , and the drain pipe abuts against the bottom wall of the cuvette.
优选地，所述清洗机构还包括磁吸件，所述磁吸件设置于对应所述出水管与所述排水管下方的转动盘上。Preferably, the cleaning mechanism further includes a magnetic attraction, and the magnetic attraction is arranged on the rotating disk corresponding to the water outlet pipe and the bottom of the drain pipe.
优选地，所述清洗机构还包括第二混匀件，所述第二混匀件设置于所述转动盘上，所述转动盘将所述反应杯转动至与所述第二混匀件抵接。Preferably, the cleaning mechanism further includes a second mixing member, the second mixing member is arranged on the rotating disk, and the rotating disk rotates the cuvette to be against the second mixing member. catch.
优选地，所述试剂样本机构包括试剂样本盘及与所述试剂样本盘连接的第二驱动件，所述试剂样本盘转动设置于所述机架上，所述第二驱动件驱动所述试剂样本盘转动以使所述试剂管及所述样本管转动至取样位。Preferably, the reagent sample mechanism includes a reagent sample disk and a second driving member connected to the reagent sample disk, the reagent sample disk is rotatably arranged on the frame, and the second driving member drives the reagent The sample disc rotates to rotate the reagent tube and the sample tube to the sampling position.
优选地，所述试剂样本机构还包括壳体，所述试剂样本盘设置于所述壳体内，所述试剂管上设有至少两个相互独立的容置腔，所述壳体内壁上设有内齿，位于最外侧的所述容置腔底部设有齿轮，所述试剂样本盘转动时所述齿轮与所述内齿啮合以带动位于最外侧的所述容置腔转动。Preferably, the reagent sample mechanism further includes a housing, the reagent sample disc is arranged in the housing, the reagent tube is provided with at least two mutually independent accommodating cavities, and the inner wall of the housing is provided with Inner teeth, gears are provided at the bottom of the outermost accommodating chamber, and when the reagent sample disk rotates, the gears mesh with the inner teeth to drive the outermost accommodating chamber to rotate.
优选地，所述POCT全自动化学发光免疫分析仪还包括采样机构，所述采用机构包括底座以及采样针，所述采样针与所述底座可移动连接，所述采样针沿所述底座移动时由所述取样位移动至所述加样位，以将所述样本管中的样本及所述试剂管中的试剂与磁珠加入到所述反应杯中。Preferably, the POCT automatic chemiluminescence immunoassay analyzer also includes a sampling mechanism, the adopting mechanism includes a base and a sampling needle, the sampling needle is movably connected to the base, and when the sampling needle moves along the base, moving from the sampling position to the adding position, so as to add the sample in the sample tube, the reagent and the magnetic beads in the reagent tube into the cuvette.
优选地，所述采样机构还包括用于清洗所述采样针的清洗部件，所述清洗部件设置于所述采样针的移动轨迹上。Preferably, the sampling mechanism further includes a cleaning component for cleaning the sampling needle, and the cleaning component is arranged on the moving track of the sampling needle.
本发明技术方案通过将反应机构设为中空结构，并将清洗机构设置在反应机构的中空结构中。采样机构移动到取样位，同时试剂样本机构将试剂样本盘中的试剂管与样本管转动到与该取样位对应的位置处，采样机构从该取样位伸入到试剂管与样本管中吸取样本、试剂及磁珠；此时，反应盘将空的反应杯转动到与加样位对应的位置处，采样机构从所述取样位移动到加样位，并将样本、试剂与磁珠放入到该空的反应杯中进行反应。反应后反应杯被转移到清洗机构上，该清洗机构可转动设置于所述反应盘的中空结构中，该清洗机构包括多组出水管及排水管以供多次对反应杯中的磁珠进行清洗，通过转动盘实现反应杯在多组出水管与排水管之间的传递，从而实现在反应机构中即可完成清洗操作，从而达到减小设备体积的目的，符合当前的临床测试需求。清洗后再将反应杯传送到光学检测机构上进行检测。The technical proposal of the present invention sets the reaction mechanism as a hollow structure, and arranges the cleaning mechanism in the hollow structure of the reaction mechanism. The sampling mechanism moves to the sampling position, and the reagent sample mechanism rotates the reagent tube and sample tube in the reagent sample tray to the position corresponding to the sampling position, and the sampling mechanism extends into the reagent tube and sample tube from the sampling position to suck the sample , reagents and magnetic beads; at this time, the reaction tray rotates the empty cuvette to the position corresponding to the sample loading position, and the sampling mechanism moves from the sampling position to the sample loading position, and puts the sample, reagent and magnetic beads into the to the empty cuvette for the reaction. After the reaction, the cuvette is transferred to the cleaning mechanism, which is rotatably installed in the hollow structure of the reaction tray. The cleaning mechanism includes multiple sets of water outlet pipes and drain pipes for multiple cleaning of the magnetic beads in the cuvette. For cleaning, the transfer of reaction cups between multiple sets of outlet pipes and drain pipes is realized by rotating the disc, so that the cleaning operation can be completed in the reaction mechanism, thereby achieving the purpose of reducing the volume of the equipment, which meets the current clinical test needs. After cleaning, the cuvette is sent to the optical detection mechanism for detection.
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图示出的结构获得其他的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. For those skilled in the art, other drawings can also be obtained according to the structures shown in these drawings without creative effort.
图1为本发明POCT全自动化学发光免疫分析仪的具体结构示意图；Fig. 1 is the specific structure schematic diagram of POCT automatic chemiluminescence immunoassay analyzer of the present invention;
图2为本发明反应机构的具体结构示意图；Fig. 2 is the specific structural representation of reaction mechanism of the present invention;
图3为本发明清洗机构的具体结构示意图；Fig. 3 is the specific structural representation of cleaning mechanism of the present invention;
图4为图3中A处的放大结构示意图；Fig. 4 is a schematic diagram of the enlarged structure at A in Fig. 3;
图5为本发明试剂样本机构的具体结构示意图；Fig. 5 is a schematic diagram of the specific structure of the reagent sample mechanism of the present invention;
图6为本发明采样机构的具体结构示意图；Fig. 6 is the concrete structural representation of sampling mechanism of the present invention;
图7为本发明抓取机构的具体结构示意图；Fig. 7 is a specific structural schematic diagram of the grasping mechanism of the present invention;
图8为本发明回收机构的具体结构示意图；Fig. 8 is the specific structural schematic diagram of recovery mechanism of the present invention;
图9为本发明外部结构示意图。Fig. 9 is a schematic diagram of the external structure of the present invention.
附图标号说明：Explanation of reference numbers:
本发明目的的实现、功能特点及优点将结合实施例，参照附图做进一步说明。The realization of the purpose of the present invention, functional characteristics and advantages will be further described in conjunction with the embodiments and with reference to the accompanying drawings.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.
需要说明，若本发明实施例中有涉及方向性指示(诸如上、下、左、右、前、后……)，则该方向性指示仅用于解释在某一特定姿态(如附图所示)下各部件之间的相对位置关系、运动情况等，如果该特定姿态发生改变时，则该方向性指示也相应地随之改变。It should be noted that if there is a directional indication (such as up, down, left, right, front, back...) in the embodiment of the present invention, the directional indication is only used to explain the position in a certain posture (as shown in the accompanying drawing). If the specific posture changes, the directional indication will also change accordingly.
另外，若本发明实施例中有涉及“第一”、“第二”等的描述，则该“第一”、“第二”等的描述仅用于描述目的，而不能理解为指示或暗示其相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。另外，各个实施例之间的技术方案可以相互结合，但是必须是以本领域普通技术人员能够实现为基础，当技术方案的结合出现相互矛盾或无法实现时应当认为这种技术方案的结合不存在，也不在本发明要求的保护范围之内。In addition, if there are descriptions involving "first", "second" and so on in the embodiments of the present invention, the descriptions of "first", "second" and so on are only for descriptive purposes, and should not be interpreted as indicating or implying Its relative importance or implicitly indicates the number of technical features indicated. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In addition, the technical solutions of the various embodiments can be combined with each other, but it must be based on the realization of those skilled in the art. When the combination of technical solutions is contradictory or cannot be realized, it should be considered that the combination of technical solutions does not exist , nor within the scope of protection required by the present invention.
本发明提出一种POCT全自动化学发光免疫分析仪，请参照图1，所述POCT全自动化学发光免疫分析仪包括：The present invention proposes a POCT automatic chemiluminescence immune analyzer, please refer to Figure 1, the POCT automatic chemiluminescent immune analyzer includes:
反应机构20，反应机构20主要用于为样本与试剂提供一个反应场所，但样本与试剂需要一定的温度才能够发生反应，在实际运用中，温度通常为37度左右。因此可在反应机构20的底部设置加热组件以对反应机构20内部进行加热，从而为样本与试剂反应提高温度条件。同时，还可以在反应机构20外部贴上保温棉以提高反应机构20内部温度的稳定性。进一步地，还可以利用温度传感器对反应机构20内部的温度进行实时监测，当反应机构20内部的温度低于预设值时，则自动打开加热组件，当反应机构20内部的温度高于预设值时，则自动关断加热组件，通过震荡循环，从而是反应机构20内部达到相对稳定的预设温度；The reaction mechanism 20, the reaction mechanism 20 is mainly used to provide a reaction place for the sample and the reagent, but the reaction between the sample and the reagent requires a certain temperature, and in practice, the temperature is usually about 37 degrees. Therefore, a heating assembly can be provided at the bottom of the reaction mechanism 20 to heat the interior of the reaction mechanism 20, thereby increasing the temperature conditions for the reaction between the sample and the reagent. At the same time, thermal insulation cotton can also be pasted on the outside of the reaction mechanism 20 to improve the stability of the internal temperature of the reaction mechanism 20 . Further, the temperature sensor can also be used to monitor the temperature inside the reaction mechanism 20 in real time. When the temperature inside the reaction mechanism 20 is lower than the preset value, the heating assembly is automatically turned on. When the temperature inside the reaction mechanism 20 is higher than the preset value value, the heating assembly is automatically turned off, and through the oscillation cycle, the inside of the reaction mechanism 20 reaches a relatively stable preset temperature;
清洗机构30，清洗机构30主要用于对反应后的反应杯22溶液进行磁珠分离。所述清洗机构30设置于所述反应机构20的中空机构中，其各自相对独立转动，互不干涉，从而达到从平面空间上减小设备体积的目；The cleaning mechanism 30, the cleaning mechanism 30 is mainly used for magnetic bead separation of the cuvette 22 solution after the reaction. The cleaning mechanism 30 is arranged in the hollow mechanism of the reaction mechanism 20, and each of them rotates relatively independently without interfering with each other, so as to achieve the purpose of reducing the volume of the equipment from the plane space;
试剂样本机构40，试剂样本机构40主要用于储存试剂管42及样本管43，在实际运用中，为了保证试剂样本机构40内的试剂与样本不被污染，通常使试剂样本机构40处于基本密封的状态，并在外部粘贴保温棉以保证试剂样本机构40内部的温度处于一个相对稳定的状态。进一步地，还可以通过降低温度以降低样本与试剂的活性，从而降低其被污染的概率，还可以在试剂样本机构40的底部设置制冷组件，该制冷组件包括但不限于半导体制冷片。该半导体制冷片制冷的一面与试剂样本机构40底部紧贴，以降低试剂样本机构40内部的温度，而发热的一面与散热片通过导热膏连接，通过风冷的方式来施行散热，及时地把制冷片所产生的热量排放到设备外部。进一步的，还可以利用温控系统随时监控试剂样本机构40内部的温度，从而使该试剂样本机构40内的温度得到有效的控制。当检测到试剂样本机构40内部温度高于预设值时，则温控系统自动打开制冷片电源使工作，直到温度降低到预设值内的范围后，制冷片停止工作。从而达到控制试剂样本机构40内部温度的目的；The reagent sample mechanism 40, the reagent sample mechanism 40 is mainly used to store the reagent tube 42 and the sample tube 43. In actual use, in order to ensure that the reagents and samples in the reagent sample mechanism 40 are not polluted, the reagent sample mechanism 40 is usually kept in a basically sealed state, and paste insulation cotton on the outside to ensure that the temperature inside the reagent sample mechanism 40 is in a relatively stable state. Further, the activity of samples and reagents can also be reduced by lowering the temperature, thereby reducing the probability of contamination, and a refrigeration component can also be installed at the bottom of the reagent sample mechanism 40, which includes but not limited to semiconductor refrigeration chips. The refrigerated side of the semiconductor refrigerating sheet is in close contact with the bottom of the reagent sample mechanism 40 to reduce the temperature inside the reagent sample mechanism 40, while the heating side is connected to the heat sink through heat conduction paste, and the heat dissipation is carried out by air cooling, so that the heat can be dissipated in time The heat generated by the cooling sheet is discharged to the outside of the device. Furthermore, the temperature control system can also be used to monitor the temperature inside the reagent sample mechanism 40 at any time, so that the temperature inside the reagent sample mechanism 40 can be effectively controlled. When it is detected that the internal temperature of the reagent sample mechanism 40 is higher than the preset value, the temperature control system automatically turns on the power supply of the cooling chip to work until the temperature drops to the range within the preset value, and the cooling chip stops working. Thereby achieving the purpose of controlling the internal temperature of the reagent sample mechanism 40;
机架10，主要用于支撑POCT全自动化学发光免疫分析仪上各个部件；所述试剂样本机构40与所述反应机构20相对设置在所述机架10上，所述反应机构20为中空结构，所述清洗机构30设置于所述反应机构20的中空结构中，用于清洗所述反应机构20中的反应杯22。The frame 10 is mainly used to support various components on the POCT automatic chemiluminescence immunoassay analyzer; the reagent sample mechanism 40 is arranged on the frame 10 opposite to the reaction mechanism 20, and the reaction mechanism 20 is a hollow structure , the cleaning mechanism 30 is disposed in the hollow structure of the reaction mechanism 20 for cleaning the cuvettes 22 in the reaction mechanism 20 .
具体的，所述POCT全自动化学发光免疫分析仪还包括抓取机构70，所述抓取机构70设置于所述机架10上以将所述反应机构20上的反应杯22抓取至所述清洗机构30上或将反应后的反应杯22抓取至所述光学检测机构60上。抓取机构70主要用于抓取并转移反应杯22。所述抓取机构70可垂直上下运动，该抓取机构70下降以抓取反应杯22，并将反应杯22提升；所述抓取机构70可横向左右移动以在各个部件之间传动该反应杯22；上述中可通过步进电机但不限于步进电机来实现抓取机构70垂直或横向运动，利用导向组件定位传动方向、位置传感器来对初始位进行定义。所述抓取机构70还包括用于将反应杯夹紧夹杯组件，该运动机构由旋转步进电机控制，自然状态下，两个夹片在弹簧的作用下向两边分开，当需要夹紧时，电机带动两个夹片向内移动，压缩弹簧，同时两片夹子对杯子外壁形成挤压，在一定压力的情况下，夹子与杯子间的摩擦力支持夹杯组件把反应杯夹起并转移到目标位置，电机旋转松开后反应杯落在目标位置，夹杯组件离开，至此反应杯转移动作完成。Specifically, the POCT automatic chemiluminescence immunoassay analyzer also includes a grasping mechanism 70, and the grasping mechanism 70 is arranged on the frame 10 to grasp the cuvette 22 on the reaction mechanism 20 to the on the cleaning mechanism 30 or grasp the cuvette 22 after the reaction onto the optical detection mechanism 60 . The grasping mechanism 70 is mainly used to grasp and transfer the cuvette 22 . The grasping mechanism 70 can move vertically up and down, and the grasping mechanism 70 descends to grasp the cuvette 22 and lifts the cuvette 22; the grasping mechanism 70 can move laterally left and right to transmit the reaction between various components. Cup 22; in the above, the vertical or lateral movement of the gripping mechanism 70 can be realized by a stepping motor but not limited to a stepping motor, and the initial position is defined by using a guide assembly to locate the transmission direction and a position sensor. The gripping mechanism 70 also includes a clamping assembly for clamping the cuvette. The movement mechanism is controlled by a rotary stepping motor. In a natural state, the two clips are separated to both sides under the action of a spring. At the same time, the motor drives the two clips to move inward, compressing the spring, and at the same time, the two clips press against the outer wall of the cup. Under a certain pressure, the friction between the clip and the cup supports the cup clamping assembly to clamp the cuvette and close it. Transfer to the target position. After the motor rotates and loosens, the cuvette falls to the target position, and the clamping cup assembly leaves, and the cuvette transfer action is completed.
具体的，所述POCT全自动化学发光免疫分析仪还包括光学检测机构60及回收机构80，所述回收机构80包括上杯位81、检测位82、排废液位83、丢杯位84及用于放置反应杯的回收盘，所述回收盘转动至所述上杯位81时接收待检测的反应杯22，所述光学检测机构60设置于与所述检测位82对应处，所述回收盘转动至所述检测位82时使所述反应杯22被所述光学检测机构60检测，所述回收盘转动至所述排废液位83时使所述反应杯22排液，所述回收盘转动至所述丢被位84时使所述反应杯22丢出回收。在实际运用中，因为光线会对光学检测机构60的测试精度产生一定影响，因此需要将光学检测机构60与回收机构设置在机架10内部，以保证处于黑暗空间进行检测。光学检测机构60主要用于采集光学信号，向反应并清洗完成后的反应杯中添加发光底物，通过抓取机构70将反应杯22移动到回收机构80的上杯位81处以准备检测，回收盘转动以使反应杯22从上杯位81转动到检测位82进行检测，检测完毕后回收盘再次转动以使反应杯22从检测位82转动至排废液位83，将杯子中的废液抽离，排废液完毕后回收盘再次转动以使反应杯22从排废液位83转动至丢杯位84，并将杯子从窗口中丢出。回收盘再转回到上杯位81等待接应下一个反应杯22，如此循环。Specifically, the POCT automatic chemiluminescence immunoassay analyzer also includes an optical detection mechanism 60 and a recovery mechanism 80, and the recovery mechanism 80 includes an upper cup position 81, a detection position 82, a waste liquid level 83, a cup loss position 84 and A recovery tray for placing cuvettes. When the recovery tray rotates to the upper cup position 81, it receives the cuvettes 22 to be detected. The optical detection mechanism 60 is arranged at a position corresponding to the detection position 82. The return tray When the closing plate rotates to the detection position 82, the cuvette 22 is detected by the optical detection mechanism 60, and when the recovery plate rotates to the waste liquid level 83, the cuvette 22 is drained, and When the disk is closed and rotated to the discarding position 84, the cuvette 22 is discarded and recovered. In practice, because light will have a certain impact on the test accuracy of the optical detection mechanism 60, it is necessary to arrange the optical detection mechanism 60 and the recovery mechanism inside the rack 10 to ensure detection in a dark space. The optical detection mechanism 60 is mainly used for collecting optical signals, adding a luminescent substrate to the cuvette after the reaction and cleaning, and moving the cuvette 22 to the upper cup position 81 of the recovery mechanism 80 through the grasping mechanism 70 to prepare for detection, and returning to Close the plate and rotate to make the cuvette 22 rotate from the upper cup position 81 to the detection position 82 for detection. After the detection is completed, the recovery plate is rotated again to rotate the cuvette 22 from the detection position 82 to the waste liquid level 83, and the waste liquid in the cup After the waste liquid is discharged, the recovery tray is rotated again so that the cuvette 22 is rotated from the waste liquid level 83 to the cup throwing position 84, and the cup is thrown out from the window. The recovery tray turns back to the upper cup position 81 to wait for the next cuvette 22, and so on.
本发明技术方案通过将反应机构20设为中空结构，并将清洗机构30设置在反应机构20的中空结构中。待试剂样本机构40中的样本与试剂添加到反应杯22中反应。反应后反应杯22被抓取机构70转移到清洗机构30上，该清洗机构30可转动设置于所述反应机构20的中空结构中，从而实现在反应机构20中即可完成清洗操作，从而达到减小设备体积的目的，符合当前的临床测试需求。清洗后再将反应杯22传送到光学检测机构60上进行检测。The technical solution of the present invention sets the reaction mechanism 20 as a hollow structure, and arranges the cleaning mechanism 30 in the hollow structure of the reaction mechanism 20 . The samples and reagents in the reagent sample mechanism 40 are added to the cuvette 22 for reaction. After the reaction, the cuvette 22 is transferred to the cleaning mechanism 30 by the grasping mechanism 70, and the cleaning mechanism 30 is rotatably arranged in the hollow structure of the reaction mechanism 20, so that the cleaning operation can be completed in the reaction mechanism 20, thereby achieving The purpose of reducing the volume of the device meets the current clinical testing requirements. After cleaning, the cuvette 22 is transferred to the optical detection mechanism 60 for detection.
具体的，所述反应机构20包括用于放置反应杯22的反应盘21、与所述反应盘21连接的第一驱动件，所述反应盘21转动设置于所述机架10上，所述第一驱动件驱动所述反应盘21转动以使所述反应杯22转动至对应的加样位23。在反应盘21上设有若干用于放置所述反应杯22的容置槽，该容置槽分布在反应盘21的内圈与外圈上，并排设置从而增加了反应杯22的承载数量，能够容纳更多的反应杯进行反应，从而提高了设备的检测效率。可以理解，反应盘21可通过步进电机与同步带配合的方式，以使反应盘21转动，从而保证每个反应杯都可以运行到的加样轨位上。在反应盘21外侧设置一码盘经过传感器后行程高低电平变化，从而可以定位各个反应杯22经过加样位23的距离，从而使反应杯22能够停留在加样位处以进行加样。Specifically, the reaction mechanism 20 includes a reaction disk 21 for placing the reaction cup 22, and a first driving member connected to the reaction disk 21, the reaction disk 21 is rotatably arranged on the frame 10, the The first driving member drives the reaction disk 21 to rotate so that the reaction cup 22 rotates to the corresponding sample adding position 23 . The reaction tray 21 is provided with a plurality of accommodating grooves for placing the cuvettes 22, the accommodating grooves are distributed on the inner and outer rings of the reaction tray 21, arranged side by side so as to increase the carrying quantity of the cuvettes 22, It can accommodate more cuvettes for reaction, thereby improving the detection efficiency of the equipment. It can be understood that the reaction disk 21 can be rotated through the cooperation of the stepping motor and the synchronous belt, so as to ensure that each cuvette can run to the sample loading track position. A code disc is set outside the reaction disc 21 and the level of stroke changes after passing the sensor, so that the distance of each cuvette 22 passing the sample adding position 23 can be determined, so that the cuvette 22 can stay at the sample adding position for sample adding.
具体的，所述清洗机构30包括升降件32、第三驱动件、用于放置所述反应杯22的转动盘31、用于注入清洗剂的出水管33及用于排水的排水管34，所述转动盘31设置于所述反应盘21的中空结构中，所述第三驱动件驱动所述转动盘31转动以使所述反应杯22转动至清洗位，所述出水管33与所述排水管34设置于所述清洗位上方，并连接所述升降件32，所述转动盘31为中空结构，所述升降件32设置于所述转动盘31的中空结构中，所述升降件32降下时使所述出水管33与所述排水34管伸入所述反应杯22中，且所述排水管34与所述反应杯22的底壁相抵接。在转动盘31上同样设有多个用于放置反应杯22的容置槽，转动盘31转动以使反应杯22转动到出水管33与排水管34的下方，升降件32与转动盘31相对独立，因此在转动盘31转动时，升降件32不会随着转动盘转动，即出水管33与排水管34相对转动盘31静止，从而使每个反应杯22都能够通过出水管33与排水管34下方进行清洗。升降件32下降以使出水管33与排水管34伸入到反应杯中，出水管33向反应杯22中加入清洗剂进行清洗，排水管34相对出水管33较长，因为排水管34需要将将清洗后的废液全部吸出，所以排水管34需要与反应杯22底部抵接以保证废液全部吸出，同时排液管34底部设有缺口，以防止管口被抵死堵塞。可以理解，清洗机构30可以包括多组出水管33与排水管34，以对反应杯22进行多次清洗以保证清洗干净。Specifically, the cleaning mechanism 30 includes a lifting member 32, a third driving member, a rotating disk 31 for placing the cuvette 22, a water outlet pipe 33 for injecting cleaning agent, and a drain pipe 34 for draining water. The rotating disk 31 is arranged in the hollow structure of the reaction disk 21, the third driving member drives the rotating disk 31 to rotate to make the reaction cup 22 rotate to the cleaning position, the outlet pipe 33 is connected to the drain The pipe 34 is arranged above the cleaning position and is connected to the lifting member 32. The rotating disk 31 is a hollow structure. The lifting member 32 is arranged in the hollow structure of the rotating disk 31. The lifting member 32 is lowered. At this time, the outlet pipe 33 and the drain pipe 34 extend into the cuvette 22 , and the drain pipe 34 abuts against the bottom wall of the cuvette 22 . A plurality of accommodating grooves for placing cuvettes 22 are also provided on the rotating disk 31. The rotating disk 31 rotates to make the cuvettes 22 rotate to the bottom of the water outlet pipe 33 and the drain pipe 34, and the lifting member 32 is opposite to the rotating disk 31. Independent, so when the rotating disk 31 rotates, the lifting member 32 will not rotate with the rotating disk, that is, the water outlet pipe 33 and the drain pipe 34 are stationary relative to the rotating disk 31, so that each cuvette 22 can pass through the water outlet pipe 33 and drain. Cleaning is performed below the tube 34. The lifting member 32 descends so that the outlet pipe 33 and the drain pipe 34 extend into the reaction cup, the outlet pipe 33 adds cleaning agent to the reaction cup 22 for cleaning, and the drain pipe 34 is longer than the outlet pipe 33, because the drain pipe 34 needs to be All the waste liquid after cleaning is sucked out, so the drain pipe 34 needs to abut against the bottom of the cuvette 22 to ensure that all the waste liquid is sucked out. At the same time, a gap is provided at the bottom of the drain pipe 34 to prevent the nozzle from being blocked. It can be understood that the cleaning mechanism 30 may include multiple sets of water outlet pipes 33 and drain pipes 34 to clean the cuvette 22 multiple times to ensure cleanliness.
具体的，所述清洗机构30还包括磁吸件，所述磁吸件设置于对应所述出水管33与所述排水管34下方的转动盘31上。因为在反应实际中含有许多磁珠，通过在转动盘31上设置一个特定强度的磁吸件，用以保证在排液时磁珠能被有效地留在反应杯22中，而其它废液则被排走。Specifically, the cleaning mechanism 30 further includes a magnetic attractor, and the magnetic attractor is disposed on the rotating disk 31 corresponding to the outlet pipe 33 and the drain pipe 34 below. Because many magnetic beads are contained in the reaction, a magnetic attraction piece with a specific strength is arranged on the rotating disk 31 to ensure that the magnetic beads can be effectively left in the cuvette 22 during liquid discharge, while other waste liquids are was drained away.
具体的，所述试剂样本机构40包括试剂样本盘41及与所述试剂样本盘连接的第二驱动件，所述试剂样本盘41转动设置于所述机架10上，所述第二驱动件驱动所述试剂样本盘41转动以使所述试剂管42及所述样本管43转动至取样位44。试剂样本盘41上试剂管42的摆放采用圆周阵列的方式，在试剂管42的间隙处为样本管43的放置位置，每一试剂管42与一样本管43对应，从而采样机构能够一次全部采样，无需多次进行清洗，提高效率。Specifically, the reagent sample mechanism 40 includes a reagent sample disk 41 and a second driving member connected to the reagent sample disk, the reagent sample disk 41 is rotatably arranged on the frame 10, and the second driving member The reagent sample disk 41 is driven to rotate to rotate the reagent tube 42 and the sample tube 43 to the sampling position 44 . The placement of the reagent tubes 42 on the reagent sample tray 41 adopts a circular array, and the gaps between the reagent tubes 42 are the placement positions of the sample tubes 43, and each reagent tube 42 corresponds to a sample tube 43, so that the sampling mechanism can collect all samples at one time. Sampling, without multiple cleaning, improve efficiency.
具体的，所述POCT全自动化学发光免疫分析仪还包括采样机构50，所述采样机构50包括底座以及采样针51，所述采样针51与所述底座可移动连接，所述采样针51沿所述底座移动时由所述取样位44移动至所述加样位23，以将所述样本管43中的样本及所述试剂管42中的试剂与磁珠加入到所述反应杯22中。所述采样针51具备液面检测功能，当该采样针51在下降的过程中，针尖接触到液面时，该采样针的电容值则会发生变化，进而在电路上给出判断信号，根据此判断信号判断采样针51到达液面，再根据实际需要做接下来的其它动作时序。Specifically, the POCT automatic chemiluminescence immunoassay analyzer also includes a sampling mechanism 50, the sampling mechanism 50 includes a base and a sampling needle 51, the sampling needle 51 is movably connected to the base, and the sampling needle 51 is movably connected to the base. When the base moves, the sampling position 44 moves to the sample adding position 23, so that the sample in the sample tube 43 and the reagent and magnetic beads in the reagent tube 42 are added to the cuvette 22 . The sampling needle 51 has a liquid level detection function. When the sampling needle 51 is in the process of descending, when the needle tip touches the liquid surface, the capacitance value of the sampling needle will change, and then a judgment signal will be given on the circuit, according to This judging signal judges that the sampling needle 51 has reached the liquid level, and then the next sequence of actions is performed according to actual needs.
进一步的，所述采样针51具备防撞功能，在采样针51的顶部设置有防撞机构。该防撞机构包括设置在所述采样针51顶部的弹性件，正常状态下由弹性件将采样针51压住，当采样针51出现触底或碰撞的情况下，采样针51通过挤压该弹性件以抵消碰撞，同时，该防撞机构还包括设置在采样针51上端的光耦及挡光片，当采样针51挤压弹性件时，所述挡光片脱离光耦，从而使得光耦改变了电路信号，从而控制停止采样针51继续下降，阻止了脆弱的采样针51被损坏，更重要的是，一旦出现扎手的现象时，采样针51也能够及时停止运动，以防进一步伤害造成。Further, the sampling needle 51 has an anti-collision function, and an anti-collision mechanism is provided on the top of the sampling needle 51 . The anti-collision mechanism includes an elastic member arranged on the top of the sampling needle 51. Under normal conditions, the elastic member presses the sampling needle 51. When the sampling needle 51 touches the bottom or collides, the sampling needle 51 squeezes the sampling needle 51 The elastic member is used to counteract the collision, and at the same time, the anti-collision mechanism also includes an optocoupler and a light shield arranged on the upper end of the sampling needle 51. When the sampling needle 51 squeezes the elastic member, the light shield is separated from the optocoupler, so that the light The coupling changes the circuit signal, thereby controlling the stop of the sampling needle 51 to continue to descend, preventing the fragile sampling needle 51 from being damaged, and more importantly, once the phenomenon of hand sticking occurs, the sampling needle 51 can also stop in time to prevent further damage cause.
作为一种实施例，其检测过程为：采样机构50移动到取样位44，同时试剂样本机构40将试剂样本盘41中的试剂管42与样本管43转动到与该取样位44对应的位置处，采样机构50从该取样位44伸入到试剂管42与样本管43中吸取样本、试剂及磁珠；此时，反应盘21将空的反应杯22转动到与加样位23对应的位置处，采样机构50从所述取样位44移动到加样位23，并将样本、试剂与磁珠放入到该空的反应杯22中进行反应。通过第一混匀机构24将反应杯中的试剂与样本混匀，混匀完成后静待样本与试剂在37°且相对密封的反应盘21中进行孵育反应。反应后反应杯22被抓取机构70转移到清洗机构30上，该清洗机构30可转动设置于所述反应盘21的中空结构中，该清洗机构30包括多组出水管33及排水管34以供多次对反应杯22中的磁珠进行清洗，磁珠通过设置在转动盘31上的磁吸件紧紧吸附在杯壁上，从而不会被排水管34排出反应杯22，通过转动盘31实现反应杯22在多组出水管33与排水管34之间的传递，从而实现在反应机构20中即可完成清洗操作，从而达到减小设备体积的目的，符合当前的临床测试需求。清洗后再将反应杯22通过抓取机构70传送反应盘21上，通过采样针51从底物瓶中取出定量的底物溶液添加到反应杯22中，并通过第一混匀件24混匀，再由抓取机构70抓取到到上杯位81，通过光学检测机构60进行检测。光学检测机构60采集反应杯22中的光电数据，亦即目标物质与底物溶液发生化学反应所产生的光子数量—光强，通过测出的光强，再结合到特定的计算公式，即可换算出该测定物的浓度值。之后通过回收机构80对反应杯22进行回收。As an embodiment, the detection process is as follows: the sampling mechanism 50 moves to the sampling position 44, and the reagent sample mechanism 40 rotates the reagent tube 42 and the sample tube 43 in the reagent sample tray 41 to the position corresponding to the sampling position 44 , the sampling mechanism 50 extends from the sampling position 44 into the reagent tube 42 and the sample tube 43 to absorb samples, reagents and magnetic beads; at this time, the reaction disk 21 rotates the empty reaction cup 22 to a position corresponding to the sample adding position 23 , the sampling mechanism 50 moves from the sampling position 44 to the sample adding position 23, and puts the samples, reagents and magnetic beads into the empty cuvette 22 for reaction. The reagent in the cuvette and the sample are mixed evenly by the first mixing mechanism 24 , and after the mixing is completed, wait for the sample and the reagent to incubate and react in the relatively sealed reaction disk 21 at 37°. After the reaction, the cuvette 22 is transferred to the cleaning mechanism 30 by the grasping mechanism 70. The cleaning mechanism 30 is rotatably arranged in the hollow structure of the reaction disk 21. The cleaning mechanism 30 includes multiple sets of water outlet pipes 33 and drain pipes 34. The magnetic beads in the cuvette 22 are cleaned for many times, and the magnetic beads are tightly adsorbed on the cup wall by the magnetic suction part arranged on the rotating disk 31, so that the cuvette 22 will not be discharged by the drain pipe 34, and the magnetic beads will pass through the rotating disk. 31 realizes the transfer of cuvettes 22 between multiple sets of water outlet pipes 33 and drain pipes 34, so that the cleaning operation can be completed in the reaction mechanism 20, thereby achieving the purpose of reducing the volume of the equipment and meeting the current clinical testing requirements. After cleaning, transfer the cuvette 22 to the reaction tray 21 through the grasping mechanism 70, take out a certain amount of substrate solution from the substrate bottle through the sampling needle 51, add it to the cuvette 22, and mix it evenly with the first mixing member 24 , and then grasped by the grasping mechanism 70 to the upper cup position 81, and then detected by the optical detection mechanism 60. The optical detection mechanism 60 collects the photoelectric data in the cuvette 22, that is, the number of photons produced by the chemical reaction between the target substance and the substrate solution—the light intensity. The measured light intensity is combined with a specific calculation formula to obtain Calculate the concentration value of the measured substance. Thereafter, the cuvette 22 is recovered by the recovery mechanism 80 .
具体的，所述反应机构20还包括用于混匀反应杯22的第一混匀件24，所述反应盘21上设有开口，所述第一混匀件24设置于所述开口处，所述反应盘21将所述反应杯22转动至所述开口处时使所述反应杯22与所述第一混匀件24抵接。所述开口使经过该位置的反应杯22部分暴露在外，反应盘21转动时，转动到该位置的反应杯22则与第一混匀件24抵接，第一混匀件24震动，从而使反应杯22内的样本、试剂与磁珠充分混匀反应。可以理解，反应盘21在内圈、外圈加样位各有一个第一混匀件24，以保证反应盘21上所有的反应杯22内的样本、试剂与磁珠充分混匀反应。Specifically, the reaction mechanism 20 also includes a first mixing member 24 for mixing the cuvette 22, the reaction plate 21 is provided with an opening, and the first mixing member 24 is arranged at the opening, When the reaction disc 21 rotates the cuvette 22 to the opening, the cuvette 22 abuts against the first mixing member 24 . The opening exposes part of the cuvette 22 that passes through this position. When the reaction disk 21 rotates, the cuvette 22 rotated to this position abuts against the first mixing member 24, and the first mixing member 24 vibrates, so that The samples, reagents and magnetic beads in the cuvette 22 are fully mixed and reacted. It can be understood that the inner ring and the outer ring of the reaction disk 21 have a first mixing member 24 respectively, so as to ensure that the samples, reagents and magnetic beads in all the reaction cups 22 on the reaction disk 21 are fully mixed and reacted.
具体的，所述清洗机构30还包括第二混匀件35，所述第二混匀件35设置于所述转动盘31上，所述转动盘31将所述反应杯22转动至与所述第二混匀件35抵接。通过第二混匀件35对磁珠进行混匀，减少因为结块、死角而造成的清洗不彻底的问题。Specifically, the cleaning mechanism 30 also includes a second mixing member 35, the second mixing member 35 is arranged on the rotating disk 31, and the rotating disk 31 rotates the cuvette 22 to the The second mixing member 35 abuts against it. The magnetic beads are mixed uniformly by the second mixing member 35 to reduce the problem of incomplete cleaning caused by agglomeration and dead ends.
具体的，所述试剂样本机构40还包括壳体，所述试剂样本盘41设置于所述壳体内，所述试剂管42上设有至少两个相互独立的容置腔，所述壳体内壁上设有内齿，位于最外侧的所述容置腔底部设有齿轮，所述试剂样本盘41转动时所述齿轮与所述内齿啮合以带动位于最外侧的所述容置腔转动。在实际运用中，不同类型的检测所需要的试剂种类不同，通常在每个试剂管42上设有四个独立的腔体，根据检测需要还可以设置更多或更少独立的腔体。该腔体分别存储各个检测项目所对应的不同的试剂成份，其中最外侧的腔体用于装载磁珠，呈圆柱体，底部带有齿轮，通过齿轮与壳体内齿轮相啮合，在试剂样本盘41转动时，该腔体可以相对自由转动，从而对试剂瓶中的磁珠溶液进行混匀，以防止磁珠沉降。Specifically, the reagent sample mechanism 40 also includes a housing, the reagent sample disc 41 is arranged in the housing, the reagent tube 42 is provided with at least two mutually independent accommodating cavities, and the inner wall of the housing Internal teeth are provided on the top, and gears are provided at the bottom of the outermost accommodating chamber. When the reagent sample disc 41 rotates, the gear meshes with the internal teeth to drive the outermost accommodating chamber to rotate. In practice, different types of tests require different types of reagents. Usually, each reagent tube 42 is provided with four independent cavities, and more or fewer independent cavities can be provided according to the detection requirements. The cavity stores different reagent components corresponding to each test item. The outermost cavity is used to load magnetic beads. It is in the shape of a cylinder with a gear at the bottom. 41 rotation, the cavity can rotate relatively freely, so as to mix the magnetic bead solution in the reagent bottle to prevent the magnetic beads from settling.
具体的，所述采样机构50还包括用于清洗所述采样针的清洗部件52，所述清洗部件设置于所述采样针51的移动轨迹上。当采样针51将试剂、样本与磁珠放入到反应杯22之后，移动到清洗部件52位置处进行清洗，以防止采样针51进行下一次采集时对样本与试剂等造成污染。Specifically, the sampling mechanism 50 further includes a cleaning component 52 for cleaning the sampling needle, and the cleaning component is arranged on the moving track of the sampling needle 51 . After the sampling needle 51 puts the reagents, samples and magnetic beads into the cuvette 22, it moves to the cleaning part 52 for cleaning, so as to prevent the sampling needle 51 from polluting the samples and reagents during the next collection.
具体的，所述采样针51为变径针管，从而保证针内的容积足够打，使定量吸取的样本或试剂不会超过针管进入管道或接头中从而难以清洗彻底，进而避免出现交叉污染。Specifically, the sampling needle 51 is a variable-diameter needle tube, so as to ensure that the volume inside the needle is sufficient, so that quantitatively drawn samples or reagents will not exceed the needle tube and enter the pipeline or joint, making it difficult to clean thoroughly, thereby avoiding cross-contamination.
以上所述仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是在本发明的发明构思下，利用本发明说明书及附图内容所作的等效结构变换，或直接/间接运用在其他相关的技术领域均包括在本发明的专利保护范围内。The above is only a preferred embodiment of the present invention, and does not therefore limit the patent scope of the present invention. Under the inventive concept of the present invention, the equivalent structural transformation made by using the description of the present invention and the contents of the accompanying drawings, or direct/indirect use All other relevant technical fields are included in the patent protection scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810569294.8ACN108469529B (en) | 2018-06-05 | 2018-06-05 | POCT full-automatic chemiluminescence immunoassay instrument |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810569294.8ACN108469529B (en) | 2018-06-05 | 2018-06-05 | POCT full-automatic chemiluminescence immunoassay instrument |
| Publication Number | Publication Date |
|---|---|
| CN108469529Atrue CN108469529A (en) | 2018-08-31 |
| CN108469529B CN108469529B (en) | 2024-09-13 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810569294.8AActiveCN108469529B (en) | 2018-06-05 | 2018-06-05 | POCT full-automatic chemiluminescence immunoassay instrument |
| Country | Link |
|---|---|
| CN (1) | CN108469529B (en) |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | Denomination of invention:POCT automatic chemiluminescence immunoassay analyzer Granted publication date:20240913 Pledgee:Shenzhen Unitone Electronics Co.,Ltd. Pledgor:SHENZHEN TIANCHEN MEDICAL TECHNOLOGY Co.,Ltd. Registration number:Y2025980036282 | |
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