技术领域technical field
本发明属于透皮给药技术领域，具体涉及一种光诱导微针透皮给药装置。The invention belongs to the technical field of transdermal drug delivery, and in particular relates to a light-induced microneedle transdermal drug delivery device.
背景技术Background technique
透皮给药是指通过在皮肤表面给药，使药物以恒定速度或接近恒定速度通过皮肤各层，进入体循环产生全身或局部治疗作用的一种给药方式。随着现代医药科技的发展，人们对精确给药及给药方式的便捷性、耐受性等方面提出了更高的要求，使透皮给药成为新一代药物制剂的研究热点。但是由于皮肤的屏障作用，大多数透皮制剂的透过率低，应用成功的药物局限于小分子量的高脂溶性非电解质药物。Transdermal drug delivery refers to a drug delivery method that allows drugs to pass through the layers of the skin at a constant or near constant rate and enter the systemic circulation to produce systemic or local therapeutic effects by administering the drug on the skin surface. With the development of modern medical technology, people have put forward higher requirements for precise drug delivery and the convenience and tolerance of drug delivery methods, making transdermal drug delivery a research hotspot for a new generation of pharmaceutical preparations. However, due to the barrier effect of the skin, most of the transdermal preparations have a low penetration rate, and the successful application of drugs is limited to small molecular weight, high fat-soluble non-electrolyte drugs.
为了克服这一障碍，近年来，科研人员相继开发出多种新技术；其中，一种结合皮下注射与透皮贴片的双重释药优点的微侵袭透皮给药系统－微针，由于微针细而尖，一般的穿刺深度仅在角质层，未接触到神经末梢，其尖度亦大幅度减低了针尖接触到神经末梢的几率，减少了对机体相应附属组织的损伤程度，显示出广阔的发展前景。微针透皮贴片可增加药物的渗透性，特别是其可使大分子药物(如多肽、蛋白和疫苗等)经皮渗透性显著提高，使其能够达到治疗效果。In order to overcome this obstacle, in recent years, researchers have developed a variety of new technologies; among them, a micro-invasive transdermal drug delivery system that combines the advantages of subcutaneous injection and transdermal patch-microneedle, The needle is thin and sharp, and the general puncture depth is only in the stratum corneum, without touching the nerve endings. Its sharpness also greatly reduces the probability of the needle tip touching the nerve endings, reduces the degree of damage to the corresponding accessory tissues of the body, and shows a broad development prospects. The microneedle transdermal patch can increase the permeability of drugs, especially it can significantly improve the transdermal permeability of macromolecular drugs (such as peptides, proteins and vaccines, etc.), so that it can achieve therapeutic effects.
众所周知，人体内血液中的离子、分子或细胞需控制在一个正常的水平范围内才能维持机能的正常运作。例如，人体在空腹状态下血糖的浓度范围为80～120mg/dL，由于饮食和活动水平的差异，人体在一天中的血糖水平也总是在发生变化。如果降血糖药物被快速地释放至人体内，则有可能引起另一种极端反应，即低血糖症，低血糖是指人体的血糖浓度持续低于60mg/dL，严重且长期的低血糖症可引发神经系统损伤与其它并发症。而采用微针透皮给药方式可较好地解决上述给药过快的问题，但目前微针透皮给药方式仅限于人为的进行给药及停止给药，其完全取决于人们的主观操作和主观判断，易造成给药不足或过量、给药不均等问题，无法达到良好的治疗效果。As we all know, the ions, molecules or cells in the blood of the human body need to be controlled within a normal level range to maintain normal functioning. For example, the concentration range of blood sugar in the human body in the fasting state is 80-120 mg/dL. Due to differences in diet and activity levels, the blood sugar level of the human body is always changing throughout the day. If the hypoglycemic drug is released into the human body quickly, it may cause another extreme reaction, that is, hypoglycemia. Causes nervous system damage and other complications. The use of microneedle transdermal drug delivery can better solve the above-mentioned problem of excessive drug delivery, but at present, the microneedle transdermal drug delivery method is limited to artificial administration and stop of drug administration, which depends entirely on people's subjective Operation and subjective judgment can easily lead to problems such as insufficient or excessive administration, uneven administration, etc., and good therapeutic effect cannot be achieved.
发明内容Contents of the invention
针对现有技术中存在的上述不足，本发明提供一种光诱导微针透皮给药装置，该装置可根据人体的生理指标信息进行给药或停止给药。In view of the above-mentioned deficiencies in the prior art, the present invention provides a light-induced microneedle transdermal drug delivery device, which can perform or stop drug delivery according to the physiological index information of the human body.
为了达到上述发明目的，本发明采用以下技术方案：In order to achieve the above object of the invention, the present invention adopts the following technical solutions:
一种光诱导微针透皮给药装置，包括基体、感测模块、发光模块和光感微针；所述感测模块设于基体上，用于监测人体生理指标信息；所述光感微针与基体或感测模块可拆卸连接；所述发光模块设于光感微针的一侧，用于根据人体生理指标信息控制光感微针释放药物。用户根据人体生理指标信息以指示控制光感微针释放药物，解决了人为主观判断易造成的给药误差问题；另外，无需手动进行给药，通过发光模块控制控制光感微针释放药物即可。A light-induced microneedle transdermal drug delivery device, including a base body, a sensing module, a light-emitting module, and a light-sensitive microneedle; the sensing module is arranged on the base body for monitoring human physiological index information; the light-sensitive microneedle It is detachably connected with the base body or the sensing module; the light-emitting module is arranged on one side of the light-sensitive microneedle, and is used to control the light-sensitive microneedle to release medicine according to the information of human physiological indicators. The user controls the light-sensitive microneedle to release the drug according to the information of human physiological indicators, which solves the problem of drug administration error easily caused by human subjective judgment; in addition, there is no need to manually administer the drug, and the light-sensitive microneedle can be controlled to release the drug through the light-emitting module .
作为优选方案，所述感测模块包括温度传感器、钠离子传感器、钾离子传感器、葡萄糖传感器和乳酸传感器中的一个或多个，还包括与传感器构成回路的参考电极。通过传感器的设置，保证监测得到的人体生理指标的准确性。As a preferred solution, the sensing module includes one or more of a temperature sensor, a sodium ion sensor, a potassium ion sensor, a glucose sensor and a lactate sensor, and also includes a reference electrode forming a loop with the sensor. Through the setting of the sensor, the accuracy of the monitored physiological indicators of the human body is guaranteed.
作为优选方案，所述感测模块为圆环状结构，传感器及参考电极均匀布设于圆环状结构的周边。其圆环状结构的内部空间用于装配其它部件，提高了装置结构的紧凑性。As a preferred solution, the sensing module is a ring-shaped structure, and the sensors and reference electrodes are evenly arranged around the ring-shaped structure. The inner space of the annular structure is used for assembling other parts, which improves the compactness of the device structure.
作为优选方案，所述透皮给药装置还包括控制模块，控制模块与发光模块、感测模块连接，控制模块接收感测模块监测的人体生理指标信息，并根据人体生理指标信息控制发光模块的打开或关闭。通过发光模块的打开或关闭以控制光感微针释放药物或停止释放药物，自动化程度高。As a preferred solution, the transdermal drug delivery device further includes a control module, the control module is connected with the light-emitting module and the sensing module, the control module receives the human body physiological index information monitored by the sensing module, and controls the light-emitting module according to the human body physiological index information On or off. The light-sensitive microneedles are controlled to release or stop releasing drugs by turning on or off the light-emitting module, and the degree of automation is high.
作为优选方案，所述透皮给药装置还包括存储模块，存储模块与控制模块连接，存储模块内存储预设的人体正常生理指标信息；所述根据人体生理指标信息控制发光模块的打开或关闭，包括：将人体生理指标信息与预设的人体正常生理指标信息进行匹配，若人体生理指标信息与预设的人体正常生理指标信息匹配，则保持或控制发光模块关闭；若人体生理指标信息与预设的人体正常生理指标信息不匹配，则控制发光模块打开。在人体生理指标出现异常时，能及时控制发光模块打开以释放药物；在人体生理指标由异常转化为正常时，还能及时控制发光模块关闭以停止释放药物，实现给药及停止给药的自由切换。As a preferred solution, the transdermal drug delivery device further includes a storage module, which is connected to the control module, and stores preset normal physiological index information of the human body in the storage module; the light-emitting module is controlled to be turned on or off according to the physiological index information of the human body. , including: matching the information of the physiological indicators of the human body with the information of the preset normal physiological indicators of the human body; If the preset normal physiological index information of the human body does not match, the light-emitting module is controlled to be turned on. When the physiological index of the human body is abnormal, it can control the light-emitting module to open in time to release the drug; when the physiological index of the human body changes from abnormal to normal, it can also control the light-emitting module to turn off in time to stop the release of the drug, so as to realize the freedom of drug administration and stop drug administration switch.
作为优选方案，所述透皮给药装置还包括遮光盖，所述遮光盖盖合于基体以使控制模块、发光模块及感测模块的第一侧位于遮光盖内。遮光盖的设置，用于保护其内部器件，并保护光感微针不受外界光源的影响。As a preferred solution, the transdermal drug delivery device further includes a light-shielding cover, and the light-shielding cover is closed to the base so that the first side of the control module, the light-emitting module and the sensing module are located in the light-shielding cover. The setting of the light-shielding cover is used to protect its internal components and protect the light-sensitive microneedles from the influence of external light sources.
作为优选方案，所述光感微针包括底座和针头，所述底座嵌入感测模块的第二侧以使针头处于外侧；所述针头包埋光致热因子和药物。通过光诱导触发光感微针中的近红外光致热转化因子产生热量并使针体融化释放出药物。As a preferred solution, the photosensitive microneedle includes a base and a needle head, the base is embedded in the second side of the sensing module so that the needle head is outside; the needle head embeds photothermal factors and medicines. The near-infrared photothermal conversion factor in the light-sensitive microneedle is triggered by light induction to generate heat and melt the needle body to release the drug.
作为优选方案，所述光致热因子为近红外光致热因子；相应地，所述发光模块为近红外光光源。采用近红外光光源无破坏性且无污染。As a preferred solution, the photothermal factor is a near-infrared photothermal factor; correspondingly, the light-emitting module is a near-infrared light source. The near-infrared light source is non-destructive and non-polluting.
作为优选方案，所述透皮给药装置还包括电源模块，电源模块与控制模块、发光模块、感测模块连接以提供电力支持。无需外接电源模块设备，使透皮给药装置的使用便利。As a preferred solution, the transdermal drug delivery device further includes a power supply module, which is connected with the control module, the light emitting module, and the sensing module to provide power support. No external power supply module equipment is needed, which makes the use of the transdermal drug delivery device convenient.
作为优选方案，所述电源模块为电压为6V的纽扣型电池。As a preferred solution, the power module is a button battery with a voltage of 6V.
作为优选方案，所述基体为手环式穿戴结构。用户使用透皮给药装置时，只需将其佩戴在手腕上，用户体验佳。As a preferred solution, the base body is a bracelet-type wearing structure. When users use the transdermal drug delivery device, they only need to wear it on the wrist, which provides a good user experience.
作为优选方案，所述近红外光光源外包覆有透明石英玻璃或有机玻璃；对近红外光光源进行保护。As a preferred solution, the near-infrared light source is covered with transparent quartz glass or plexiglass; the near-infrared light source is protected.
作为优选方案，近红外光光源发射波长为808nm的近红外光。As a preferred solution, the near-infrared light source emits near-infrared light with a wavelength of 808nm.
本发明与现有技术相比，有益效果是：本发明的光诱导微针透皮给药装置，能对体内的各类生理指标水平进行智能响应，当其高于正常水平时能加快微针针体装载药物的释放，而当其低于正常水平时能减缓药物的释放速率，形成一个传感诊断和药物可控释放治疗的循环体系，实现药物补给的高度自动化和智能化，具有较为光明的应用前景。Compared with the prior art, the present invention has the beneficial effects that: the light-induced microneedle transdermal drug delivery device of the present invention can intelligently respond to various physiological index levels in the body, and can accelerate microneedle injection when the level is higher than the normal level. The needle is loaded with drug release, and when it is lower than the normal level, it can slow down the release rate of the drug, forming a circulatory system of sensory diagnosis and drug controllable release therapy, realizing highly automated and intelligent drug supply, and has a relatively bright future. application prospects.
附图说明Description of drawings
图1是本发明实施例一的光诱导微针透皮给药装置的结构示意图；Figure 1 is a schematic structural view of a light-induced microneedle transdermal drug delivery device according to Example 1 of the present invention;
图2是本发明实施例一的光诱导微针透皮给药装置的结构爆炸图；Fig. 2 is an exploded view of the structure of the light-induced microneedle transdermal drug delivery device in Example 1 of the present invention;
图3是本发明实施例一的感测模块中各传感器及参考电极的结构示意图；3 is a schematic structural diagram of sensors and reference electrodes in the sensing module according to Embodiment 1 of the present invention;
图4是本发明实施例一的光诱导微针透皮给药装置中光感微针分离的结构示意图；Fig. 4 is a schematic diagram of the separation of light-sensitive microneedles in the light-induced microneedle transdermal drug delivery device according to Example 1 of the present invention;
图5是本发明实施例一的光诱导微针透皮给药装置佩戴于手腕时的结构示意图。Fig. 5 is a schematic structural view of the light-induced microneedle transdermal drug delivery device according to Example 1 of the present invention when it is worn on the wrist.
具体实施方式Detailed ways
下面通过具体实施例对本发明的技术方案作进一步描述说明。The technical solutions of the present invention will be further described and illustrated through specific examples below.
于实施例一中，如图1-5所示，本实施例的光诱导微针透皮给药装置，包括基体1、感测模块2、发光模块3、光感微针4、控制模块5、电源模块6和遮光盖7，基体1为手环式穿戴结构，优选地，基体1为手表型腕带结构，可以佩戴于手腕上；基体1的材质为柔性材质，优选为热塑性硅橡胶，热塑性硅橡胶为硫化硅橡胶颗粒在热塑性基材上形成的热塑性有机硅弹性体；通过有机硅的表面富集性和憎水性，拓展了热塑性弹性体和热塑性硫化胶的性能，使其具有优良的抗高温性能，高温时的低拉伸性和压缩性以及良好的耐磨性、抗水解性和耐化学；材料的回弹性好，比一般的热塑性聚氨酯弹性体橡胶TPU软；表面不易吸附灰尘，不发粘，而且抗油性和抗化学性好，不易污染；包覆性比较好，与许多热塑性工程塑料如PC、PC/ABS、ABS、PA、PVC等具有优异的粘接性，成型方便，可共挤、双注射成型，二次注塑；还可雕刻丰富图案，可以着色得到多彩的腕带。In Embodiment 1, as shown in Figures 1-5, the light-induced microneedle transdermal drug delivery device of this embodiment includes a base 1, a sensing module 2, a light-emitting module 3, a light-sensitive microneedle 4, and a control module 5 , the power module 6 and the light-shielding cover 7, the base body 1 is a bracelet-type wearing structure, preferably, the base body 1 is a watch-type wristband structure, which can be worn on the wrist; the material of the base body 1 is a flexible material, preferably thermoplastic silicone rubber, Thermoplastic silicone rubber is a thermoplastic silicone elastomer formed by vulcanized silicone rubber particles on a thermoplastic substrate; through the surface enrichment and hydrophobicity of silicone, the performance of thermoplastic elastomer and thermoplastic vulcanizate is expanded, making it have excellent High temperature resistance, low stretchability and compression at high temperature and good wear resistance, hydrolysis resistance and chemical resistance; the material has good resilience and is softer than the general thermoplastic polyurethane elastomer rubber TPU; the surface is not easy to absorb dust, It is not sticky, and has good oil and chemical resistance, and is not easy to be polluted; it has good coating performance, and has excellent adhesion to many thermoplastic engineering plastics such as PC, PC/ABS, ABS, PA, PVC, etc., and is easy to form. It can be co-extruded, double-injected, and double-injected; it can also be engraved with rich patterns, and can be colored to obtain colorful wristbands.
基体1的中部表盘的位置处装配圆环状结构的感测模块2，用于监测人体生理指标信息；感测模块2为圆环状结构，外径为5cm，内径为4cm；包括贴近人体皮肤面配置的温度传感器24、钠离子传感器21、钾离子传感器22、葡萄糖传感器26、乳酸传感器27以及与传感器构成回路的参考电极，用于检测皮肤上汗液的组成，以得到人体生理指标信息，如人体的体表温度、钠离子浓度水平、锂离子浓度水平、葡萄糖浓度水平和乳酸浓度水平；具体地，如图3所示，由钾离子传感器22、钠离子传感器21和银/氯化银电极23构成回路检测汗液中的盐类的浓度水平，由葡萄糖传感器26、乳酸传感器27和聚乙烯醇缩丁醛PVB参考电极25构成回路检测汗液中的葡萄糖水平和乳酸水平，同时搭载了温度传感器24用于检测体表温度；上述传感器及参考电极均匀布设于圆环状结构的周边；通过上述传感器的设置，保证监测得到的人体生理指标的准确性，为后续药物的可控释放提供了依据。A ring-shaped sensing module 2 is assembled at the position of the middle dial of the base body 1 to monitor human physiological index information; the sensing module 2 is a ring-shaped structure with an outer diameter of 5 cm and an inner diameter of 4 cm; A temperature sensor 24, a sodium ion sensor 21, a potassium ion sensor 22, a glucose sensor 26, a lactic acid sensor 27, and a reference electrode forming a circuit with the sensors are arranged on the surface, and are used to detect the composition of sweat on the skin to obtain information on human physiological indicators, such as Body surface temperature, sodium ion concentration level, lithium ion concentration level, glucose concentration level and lactic acid concentration level of the human body; specifically, as shown in Figure 3, the potassium ion sensor 22, the sodium ion sensor 21 and the silver/silver chloride electrode 23 forms a circuit to detect the concentration level of salts in sweat, a glucose sensor 26, a lactic acid sensor 27 and a polyvinyl butyral PVB reference electrode 25 form a circuit to detect the glucose level and lactic acid level in sweat, and a temperature sensor 24 is also equipped It is used to detect body surface temperature; the above-mentioned sensors and reference electrodes are evenly arranged around the ring-shaped structure; through the arrangement of the above-mentioned sensors, the accuracy of the monitored human physiological indicators is guaranteed, which provides a basis for the subsequent controlled release of drugs.
感测模块2与控制模块5连接，感测模块2将感测得到的人体生理指标信息发送至控制模块5；具体地，温度传感器、钠离子传感器、钾离子传感器、葡萄糖传感器、乳酸传感器均与控制模块5连接，以便于将各自监测的生理指标信息发送至控制模块5。The sensing module 2 is connected with the control module 5, and the sensing module 2 sends the sensed human physiological index information to the control module 5; specifically, the temperature sensor, sodium ion sensor, potassium ion sensor, glucose sensor, and lactate sensor are all connected with The control module 5 is connected so as to send the monitored physiological index information to the control module 5 .
光感微针4包括底座和针头，底座由高分子材料制成圆形贴片状，高分子材料选用明胶、海藻酸钠、透明质酸、聚己内酯和十三酸中的一种或几种；针头以阵列式分布于底座上，针头由具有较低的玻璃化转化温度或者较低熔点的高分子材料制得，并在其内包埋近红外光致热因子和药物组成。底座可拆卸地嵌入圆环状结构的感测模块2内周边的下侧以使针头处于最下侧，便于针头与皮肤直接接触；设置为可拆卸连接方式可使光感微针可替换。其中，光致热因子为近红外光致热因子，优选为普鲁士蓝。The light-sensitive microneedle 4 includes a base and a needle head. The base is made of a polymer material in a circular patch shape. The polymer material is selected from one or more of gelatin, sodium alginate, hyaluronic acid, polycaprolactone and tridecanoic acid. Several types; the needles are distributed on the base in an array, and the needles are made of polymer materials with a lower glass transition temperature or lower melting point, and are composed of near-infrared photothermal factors and drugs embedded in them. The base is detachably embedded in the lower side of the inner periphery of the sensing module 2 of the circular structure so that the needle is at the lowest side, which facilitates direct contact between the needle and the skin; the light-sensitive microneedle can be replaced by being set in a detachable connection. Wherein, the photothermal factor is a near-infrared photothermal factor, preferably Prussian blue.
感测模块2的上方设置发光模块3，发光模块3为近红外光光源，采用近红外光光源无破坏性且无污染；近红外光光源发射波长为808nm的近红外光，用于触发光热因子普鲁士蓝产生热量，以使针头融化从而释放药物。另外，近红外光光源外设有保护罩，保护罩为透明石英玻璃或有机玻璃，对近红外光光源进行保护；保护罩抵靠于圆环状结构的感测模块2的上侧以限制保护罩向下活动。其中，在保护罩内设置有四个近红外光源。A light-emitting module 3 is arranged above the sensing module 2. The light-emitting module 3 is a near-infrared light source, and the use of a near-infrared light source is non-destructive and non-polluting; the near-infrared light source emits near-infrared light with a wavelength of 808nm for triggering photothermal Factor Prussian blue generates heat to melt the needle and release the drug. In addition, a protective cover is provided outside the near-infrared light source, and the protective cover is transparent quartz glass or plexiglass to protect the near-infrared light source; The hood moves downward. Wherein, four near-infrared light sources are arranged in the protective cover.
发光模块3的上方设置控制模块5，即保护罩的上方设置控制模块5，控制模块5与发光模块3连接，用于根据人体生理指标信息以指示控制光感微针释放药物，解决了人为主观判断易造成的给药误差问题。具体地，控制模块5对人体生理指标信息进行分析并根据人体生理指标信息控制发光模块的打开或关闭，从而控制光感微针释放药物或停止释放药物。A control module 5 is set above the light-emitting module 3, that is, a control module 5 is set above the protective cover. The control module 5 is connected to the light-emitting module 3, and is used to control the light-sensitive microneedles to release drugs according to the information of human physiological indicators, which solves the problem of human subjective Judgment of easily caused drug administration errors. Specifically, the control module 5 analyzes the physiological index information of the human body and controls the light-emitting module to be turned on or off according to the physiological index information of the human body, so as to control the light-sensitive microneedle to release the drug or stop releasing the drug.
本实施例的光诱导微针透皮给药装置还包括存储模块，存储模块与控制模块5连接，存储模块内存储有预设的人体正常生理指标信息，如上述的人体的体表温度、钠离子浓度水平、锂离子浓度水平、葡萄糖浓度水平和乳酸浓度水平等。控制模块5根据人体生理指标信息控制发光模块的打开或关闭，具体包括：将实际测量的人体生理指标信息与预设的人体正常生理指标信息进行匹配，若实际测量的人体生理指标信息与预设的人体正常生理指标信息匹配，当发光模块处于打开状态，则将发光模块关闭；当发光模块处于关闭状态，则保持发光模块关闭；若人体生理指标信息与预设人体正常生理指标信息不匹配，则控制发光模块打开。在人体生理指标出现异常时，能及时控制发光模块打开以释放药物；在人体生理指标由异常转化为正常时，还能及时控制发光模块关闭以停止释放药物，实现给药及停止给药的自由切换。The light-induced microneedle transdermal drug delivery device of this embodiment also includes a storage module, which is connected to the control module 5, and preset normal physiological index information of the human body is stored in the storage module, such as the above-mentioned body surface temperature of the human body, sodium ion concentration level, lithium ion concentration level, glucose concentration level and lactic acid concentration level etc. The control module 5 controls the opening or closing of the light-emitting module according to the physiological index information of the human body, specifically including: matching the actually measured physiological index information of the human body with the normal physiological index information of the human body; When the light-emitting module is in the open state, turn off the light-emitting module; when the light-emitting module is in the off state, keep the light-emitting module off; if the human body physiological index information does not match the preset human body normal physiological index information, Then control the light emitting module to turn on. When the physiological index of the human body is abnormal, it can control the light-emitting module to open in time to release the drug; when the physiological index of the human body changes from abnormal to normal, it can also control the light-emitting module to turn off in time to stop the release of the drug, so as to realize the freedom of drug administration and stop drug administration switch.
其中，控制模块5可以是搭载有处理器芯片的电路板，通过各种处理器芯片完成逻辑运行和运算，例如，处理器芯片可以为CPLD(Complex Programmable Logic Device，复杂可编程逻辑器件)和FPGA(Field Programmable Gate Array，现场可编程门阵列)。Wherein, control module 5 can be the circuit board that is equipped with processor chip, completes logical operation and operation by various processor chips, for example, processor chip can be CPLD (Complex Programmable Logic Device, complex programmable logic device) and FPGA (Field Programmable Gate Array, Field Programmable Gate Array).
控制模块5的上方设置电源模块6，电源模块6与控制模块5、发光模块3、感测模块2连接以提供电力支持；无需外接电源模块设备，使透皮给药装置的使用更加便利。具体地，电源模块6为电压为6V的纽扣型电池，电源模块6与控制模块5、发光模块3以及感测模块2中的各种传感器电连接。A power module 6 is arranged above the control module 5, and the power module 6 is connected with the control module 5, the light emitting module 3, and the sensing module 2 to provide power support; no external power module equipment is needed, which makes the use of the transdermal drug delivery device more convenient. Specifically, the power module 6 is a button battery with a voltage of 6V, and the power module 6 is electrically connected with various sensors in the control module 5 , the light emitting module 3 and the sensing module 2 .
遮光盖7为上、下端均开口的圆筒形结构，遮光盖7的下端口从上至下依次贯穿电源模块6、控制模块5、发光模块3至感测模块2的上侧并与基体1固定连接；固定连接的方式为螺纹连接或卡扣连接；遮光盖7的上端口设有可拆卸式盖体，当盖体盖合于遮光盖7的上端口时，遮光盖7内的电源模块6、控制模块5、发光模块3、感测模块2被限制上下活动，从而提高了光诱导微针透皮给药装置的结构紧凑性。遮光盖的设置，还保护了其内部的器件，并保护光感微针在使用时不受外界光源的影响。其中，盖体设置为可拆卸式便于电池的更换。The light-shielding cover 7 is a cylindrical structure with both upper and lower ends open. The lower port of the light-shielding cover 7 runs through the power supply module 6, the control module 5, the light-emitting module 3 to the upper side of the sensing module 2 from top to bottom and connects with the base 1 Fixed connection; the way of fixed connection is screw connection or buckle connection; the upper port of the light-shielding cover 7 is provided with a detachable cover body, when the cover is closed on the upper port of the light-shielding cover 7, the power module in the light-shielding cover 7 6. The control module 5, the light emitting module 3, and the sensing module 2 are restricted from moving up and down, thereby improving the structural compactness of the light-induced microneedle transdermal drug delivery device. The setting of the light-shielding cover also protects the internal devices and protects the light-sensitive microneedles from being affected by external light sources during use. Wherein, the cover body is set to be detachable to facilitate battery replacement.
本实施例的光诱导微针透皮给药装置的装配流程如下：将感测模块2装配于基体1的表盘位置处；将发光模块3正对于感测模块2并抵靠于感测模块2的上方；将控制模块5放置于发光模块3的上方；将电源模块6放置于控制模块5的上方，布置好相应的线路连接后将遮光盘7从上至下将上述模块罩于其内，并将遮光盖与基体固定连接，将盖体盖合于遮光盖的上端口；最后，将光感微针4嵌入感测模块2的内周边从而将光感微针4固定；用户使用该光诱导微针透皮给药装置时，如同佩戴手表般即可，使用方便。其中，光感微针4的装配顺序不作具体的限定，在装配完感测模块2之后也可进行安装。The assembly process of the light-induced microneedle transdermal drug delivery device of this embodiment is as follows: the sensing module 2 is assembled on the dial position of the base 1; the light emitting module 3 is facing the sensing module 2 and abutting against the sensing module 2 Place the control module 5 above the light-emitting module 3; place the power supply module 6 above the control module 5, arrange the corresponding line connections and cover the above-mentioned modules with the shielding disk 7 from top to bottom, And the light-shielding cover is fixedly connected with the base, and the cover is closed on the upper port of the light-shielding cover; finally, the light-sensitive microneedle 4 is embedded into the inner periphery of the sensing module 2 to fix the light-sensitive microneedle 4; When inducing the microneedle transdermal drug delivery device, it is as easy to use as wearing a watch. Wherein, the assembly order of the photosensitive microneedle 4 is not specifically limited, and it can also be installed after the sensing module 2 is assembled.
本发明的光诱导微针透皮给药装置将微针给药技术、光控释放药物技术及微纳电子传感技术相结合，实现可智能光控释放微针的载药，克服了一系列相关的难题；一方面，既保留了药物泵的优点(可变的药物释放)，消除了药物泵和病人之间的复杂管路连接，又能够避免化疗、传统皮下频繁注射给患者造成身体、精神和经济上的多重压力；另一方面，光控药物释放可有效调控药物的释放速率，避免药物过快或过慢释放，从而提高光控药物释放的安全性和有效性；还利用微电子传感技术继续实时监测体内各类指标的变化，调节药物的释放，最终实现智能给药的目标。本发明的光诱导微针透皮给药装置，能够为慢性疾病的治疗创造一个更加舒适，容易接受的治疗方式。The light-induced microneedle transdermal drug delivery device of the present invention combines microneedle drug delivery technology, light-controlled drug release technology and micro-nano electronic sensing technology, realizes drug loading of intelligent light-controlled release microneedles, and overcomes a series of problems. Related problems; on the one hand, it not only retains the advantages of the drug pump (variable drug release), eliminates the complicated pipeline connection between the drug pump and the patient, but also avoids the physical and Multiple mental and economic pressures; on the other hand, light-controlled drug release can effectively regulate the release rate of drugs, avoiding too fast or too slow drug release, thereby improving the safety and effectiveness of light-controlled drug release; also using microelectronics Sensing technology continues to monitor the changes of various indicators in the body in real time, adjust the release of drugs, and finally achieve the goal of intelligent drug delivery. The light-induced microneedle transdermal drug delivery device of the present invention can create a more comfortable and acceptable treatment mode for the treatment of chronic diseases.
于具体应用实例中，通过上述传感器对皮肤表面的汗液进行检测，从而对血糖水平进行估算，当血糖高于正常浓度时，通过控制模块利用近红外光照射光感微针，使光感微针的针头融化，释放出装载的药物；当控制药物释放并使血糖水平恢复到正常的浓度时，控制模块将会控制光源关闭，从而使光感微针逐渐停止融化，停止药物的释放。针对实际生理情况有针对性地给药或停止给药，实现药物释放的智能化控制。In a specific application example, the above sensor is used to detect the sweat on the surface of the skin, thereby estimating the blood sugar level. When the blood sugar is higher than the normal concentration, the control module uses near-infrared light to irradiate the light-sensitive microneedle, so that the light-sensitive microneedle The needle melts to release the loaded drug; when the release of the drug is controlled and the blood sugar level returns to a normal concentration, the control module will control the light source to turn off, so that the light-sensitive microneedle gradually stops melting and releases the drug. According to the actual physiological situation, the drug is administered or stopped in a targeted manner, and the intelligent control of drug release is realized.
作为优选实施例，本实施例的光诱导微针透皮给药装置与实施例一的不同之处在于：光感微针与感测模块可拆卸连接更改为光感微针与基体可拆卸连接，实现光诱导微针透皮给药装置的结构多样化。其它结构参照实施例一。As a preferred embodiment, the light-induced microneedle transdermal drug delivery device of this embodiment is different from the first embodiment in that: the detachable connection between the light-sensitive microneedle and the sensing module is changed to the detachable connection between the light-sensitive microneedle and the base , to achieve structural diversification of light-induced microneedle transdermal drug delivery devices. Refer to Embodiment 1 for other structures.
作为优选实施例，本实施例的光诱导微针透皮给药装置与实施例一的不同之处在于：发光模块与感测模块之间设有粘合层，控制模块与发光模块之间设有粘合层，电源模块与控制模块之间设有粘合层，提高光诱导微针透皮给药装置整体结构的稳定性。其它结构参照实施例一。As a preferred embodiment, the light-induced microneedle transdermal drug delivery device of this embodiment differs from Embodiment 1 in that an adhesive layer is provided between the light-emitting module and the sensing module, and an adhesive layer is provided between the control module and the light-emitting module. There is an adhesive layer, and an adhesive layer is provided between the power supply module and the control module to improve the stability of the overall structure of the light-induced microneedle transdermal drug delivery device. Refer to Embodiment 1 for other structures.
作为优选实施例，本实施例的光诱导微针透皮给药装置与实施例一的不同之处在于：光诱导微针透皮给药装置还包括显示模块，显示模块与控制模块连接，用于显示实时监测的各项生理指标信息，以使用户能直观了解自身的生理状况。其它结构参照实施例一。As a preferred embodiment, the difference between the light-induced microneedle transdermal drug delivery device of this embodiment and the first embodiment is that the light-induced microneedle transdermal drug delivery device also includes a display module, and the display module is connected with the control module. It is used to display various physiological index information monitored in real time, so that users can intuitively understand their own physiological conditions. Refer to Embodiment 1 for other structures.
应当说明的是，上述实施例均可根据需要自由组合。以上所述仅是对本发明的优选实施例及原理进行了详细说明，对本领域的普通技术人员而言，依据本发明提供的思想，在具体实施方式上会有改变之处，而这些改变也应视为本发明的保护范围。It should be noted that the above embodiments can be freely combined as required. The above is only a detailed description of the preferred embodiments and principles of the present invention. For those of ordinary skill in the art, according to the ideas provided by the present invention, there will be changes in the specific implementation, and these changes should also be It is regarded as the protection scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711474319.8ACN108310615B (en) | 2017-12-29 | 2017-12-29 | A light-induced microneedle transdermal drug delivery device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711474319.8ACN108310615B (en) | 2017-12-29 | 2017-12-29 | A light-induced microneedle transdermal drug delivery device |
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| CN108310615Atrue CN108310615A (en) | 2018-07-24 |
| CN108310615B CN108310615B (en) | 2021-06-08 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711474319.8AActiveCN108310615B (en) | 2017-12-29 | 2017-12-29 | A light-induced microneedle transdermal drug delivery device |
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| CN (1) | CN108310615B (en) |
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