技术领域technical field
本发明涉及医疗器材领域，具体而言，涉及一种骨缺损填充支架结构。The invention relates to the field of medical equipment, in particular to a bone defect filling bracket structure.
背景技术Background technique
各种创伤、感染和疾病导致的器官缺损的治疗仍是医学难题之一，组织工程领域的发展为构建“安全、有效的组织器官移植替代物”带来了新希望，尤其是3D打印技术，可根据缺损的位置和形态设计个性化的支架材料。体外将材料复合外源性种子细胞一直是组织工程学研究的热点，但近年来，越来越多的学者认识到外源性细胞很少直接参与组织修复，而内源性细胞在修复重建中起到至关重要的作用。因此，促进内源性细胞的浸润对组织工程修复效果的提升具有重要意义。The treatment of organ defects caused by various traumas, infections and diseases is still one of the medical problems. The development of tissue engineering has brought new hope for the construction of "safe and effective tissue and organ transplant substitutes", especially 3D printing technology, Individualized scaffold materials can be designed according to the location and shape of the defect. Combining materials with exogenous seed cells in vitro has always been a hot spot in tissue engineering research, but in recent years, more and more scholars have realized that exogenous cells are rarely directly involved in tissue repair, while endogenous cells play a role in repair and reconstruction. play a vital role. Therefore, promoting the infiltration of endogenous cells is of great significance to the improvement of tissue engineering repair effect.
内源性细胞的迁移和爬行替代必须依附于支架结构，特别是在术后早期，材料结构直接影响了细胞的存活和归巢。在组织工程尤其是骨组织工程的研究中发现，细胞浸润具有明显的趋势和方向，如图1所示，传统的骨缺损填充支架结构多采用叠层结构，其包括多根横向支撑杆1和纵向支撑杆2，横向支撑杆1和纵向支撑杆2纵横交错形成网孔结构从而促进细胞的长入。The migration and crawling replacement of endogenous cells must be attached to the scaffold structure, especially in the early postoperative period, the material structure directly affects the survival and homing of cells. In the study of tissue engineering, especially bone tissue engineering, it is found that cell infiltration has a clear trend and direction. As shown in Figure 1, the traditional bone defect filling scaffold structure mostly adopts a laminated structure, which includes multiple transverse support rods 1 and The longitudinal support rods 2, the horizontal support rods 1 and the longitudinal support rods 2 are criss-crossed to form a mesh structure to promote the growth of cells.
然而密集交错的横向支撑杆1和纵向支撑杆2的会形成界壁遮挡，内源性细胞只能从外向内、层间向上、向下3个方向迁移，导致细胞的浸润速度和数量明显受到抑制。However, the densely staggered horizontal support rods 1 and longitudinal support rods 2 will form a barrier barrier, and endogenous cells can only migrate from outside to inside, interlayer upward, and downward, resulting in a significant decrease in the infiltration speed and number of cells. inhibition.
发明内容Contents of the invention
本发明的主要目的在于提供一种骨缺损填充支架结构，以至少解决现有技术中的支架结构存在界壁遮挡而影响细胞的浸润速度和数量的问题。The main purpose of the present invention is to provide a scaffold structure for bone defect filling, so as to at least solve the problem in the prior art that the scaffold structure is blocked by a boundary wall and affects the infiltration speed and quantity of cells.
为了实现上述目的，根据本发明，提供了一种骨缺损填充支架结构，包括：多层筒状基层，筒状基层上具有网孔结构，多层筒状基层逐层嵌套设置以在骨缺损填充支架结构植入骨缺损位置时使内源性细胞沿多层筒状基层的径向、轴向以及周向迁移；层间连接杆，设置在相邻的两层筒状基层之间，用于将多层筒状基层相互连接固定。In order to achieve the above object, according to the present invention, a bone defect filling scaffold structure is provided, including: a multi-layer cylindrical base layer with a mesh structure, and the multi-layer cylindrical base layer is nested layer by layer to form a bone defect. When the scaffold structure is implanted into the bone defect, the endogenous cells migrate along the radial, axial and circumferential directions of the multi-layer cylindrical base; It is used to connect and fix the multi-layer cylindrical base layer to each other.
进一步地，筒状基层包括：多个环形圈，多个环形圈沿其轴心线方向相互间隔设置；多根环间连接杆，多根环间连接杆沿环形圈周向相互间隔设置以将多个环形圈相互连接；其中，各个环形圈与各根环间连接杆相互交错以形成筒状基层的网孔结构。Further, the cylindrical base layer includes: a plurality of annular rings, the plurality of annular rings are arranged at intervals along the direction of the axis line; a plurality of connecting rods between the rings, and the plurality of inter-annular connecting rods are arranged at intervals along the circumferential direction of the annular rings to connect A plurality of annular rings are connected to each other; wherein, each annular ring and each connecting rod between the rings are interlaced to form a mesh structure of the cylindrical base.
进一步地，多个环形圈之间相互平行。Further, the plurality of annular rings are parallel to each other.
进一步地，多个环形圈之间的间距相等。Further, the intervals between the plurality of annular rings are equal.
进一步地，各根环间连接杆之间相互平行。Further, the connecting rods between the rings are parallel to each other.
进一步地，各根环间连接杆之间的间距相等。Further, the distances between the connecting rods between the rings are equal.
进一步地，层间连接杆为多根，多根层间连接杆沿环形圈周向间隔设置和/或多根层间连接杆沿环形圈轴向间隔设置。Further, there are multiple interlayer connecting rods, and the plurality of interlayer connecting rods are arranged at intervals along the circumferential direction of the annular ring and/or the plurality of interlayer connecting rods are arranged at intervals along the axial direction of the annular ring.
进一步地，每根层间连接杆与其中一个环形圈共面；且每根层间连接杆与其中一根环间连接杆或者沿环形圈的径向相对的两根环间连接杆相交。Further, each interlayer connecting rod is coplanar with one of the annular rings; and each interlayer connecting rod intersects with one of the interannular connecting rods or two interannulus connecting rods radially opposite to each other along the annular ring.
进一步地，骨缺损填充支架结构由磷酸三钙、羟基磷灰石、壳聚糖、胶原蛋白采用3D打印技术制成。Further, the bone defect filling scaffold structure is made of tricalcium phosphate, hydroxyapatite, chitosan, and collagen using 3D printing technology.
进一步地，骨缺损填充支架结构中添加有以下各种组织修复因子的至少之一：骨形态发生蛋白、血管内皮生长因子、成纤维细胞生长因子、转化生长因子-β、胶原、富血小板纤维蛋白、富血小板血浆。Further, at least one of the following tissue repair factors is added to the bone defect filling scaffold structure: bone morphogenetic protein, vascular endothelial growth factor, fibroblast growth factor, transforming growth factor-β, collagen, platelet-rich fibrin , Platelet-rich plasma.
应用本发明技术方案的骨缺损填充支架结构，包括：多层筒状基层，筒状基层上具有网孔结构，多层筒状基层逐层嵌套设置以在骨缺损填充支架结构植入骨缺损位置时使内源性细胞沿多层筒状基层的径向、轴向以及周向迁移；层间连接杆设置在相邻的两层筒状基层之间，用于将多层筒状基层相互连接固定。本发明的骨缺损填充支架结构减少了界壁遮挡，能够使内源性细胞沿多个方向自由迁移，加速细胞的浸润速度和数量，解决了现有技术中的支架结构存在界壁遮挡而影响细胞的浸润速度和数量的问题。The bone defect filling scaffold structure applying the technical solution of the present invention includes: a multi-layer cylindrical base layer with a mesh structure, and the multi-layer cylindrical base layer is nested layer by layer to implant the bone defect in the bone defect filling scaffold structure The position enables the endogenous cells to migrate along the radial, axial and circumferential directions of the multi-layer cylindrical base; the interlayer connecting rod is arranged between two adjacent layers of cylindrical base, and is used to connect the multi-layer cylindrical base to each other. The connection is fixed. The bone defect filling scaffold structure of the present invention reduces the shielding of the boundary wall, enables the free migration of endogenous cells in multiple directions, accelerates the infiltration speed and quantity of the cells, and solves the problem caused by the shielding of the boundary wall in the scaffold structure in the prior art. The speed and quantity of cell infiltration.
附图说明Description of drawings
此处所说明的附图用来提供对本发明的进一步理解，构成本申请的一部分，本发明的示意性实施例及其说明用于解释本发明，并不构成对本发明的不当限定。在附图中：The accompanying drawings described here are used to provide a further understanding of the present invention and constitute a part of the application. The schematic embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations to the present invention. In the attached picture:
图1是现有的骨缺损填充支架结构的示意图；Fig. 1 is the schematic diagram of existing bone defect filling scaffold structure;
图2是根据本发明实施例可选的一种骨缺损填充支架结构的第一视角的结构示意图；Fig. 2 is a structural schematic diagram of a first viewing angle of an optional bone defect filling scaffold structure according to an embodiment of the present invention;
图3是根据本发明实施例可选的一种骨缺损填充支架结构的第二视角的结构示意图；Fig. 3 is a structural schematic diagram of a second viewing angle of an optional bone defect filling scaffold structure according to an embodiment of the present invention;
图4是根据本发明实施例可选的一种骨缺损填充支架结构在手术时的安装结构示意图。Fig. 4 is a schematic diagram of an optional bone defect filling stent structure during surgery according to an embodiment of the present invention.
其中，上述附图包括以下附图标记：Wherein, the above-mentioned accompanying drawings include the following reference signs:
10、筒状基层；11、环形圈；12、环间连接杆；20、层间连接杆；30、自体骨；40、固定支板；50、支架结构。10. Cylindrical base; 11. Annular ring; 12. Connecting rod between rings; 20. Connecting rod between layers; 30. Autogenous bone; 40. Fixed support plate; 50. Bracket structure.
具体实施方式Detailed ways
为了使本技术领域的人员更好地理解本发明方案，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分的实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都应当属于本发明保护的范围。In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.
根据本发明实施例，如图2和图3所示，提供了一种骨缺损填充支架结构，包括多层筒状基层10和层间连接杆20，筒状基层10上具有网孔结构，多层筒状基层10逐层嵌套设置以在骨缺损填充支架结构植入骨缺损位置时使内源性细胞沿多层筒状基层10的径向、轴向以及周向迁移；层间连接杆20设置在相邻的两层筒状基层10之间，用于将多层筒状基层10相互连接固定。According to the embodiment of the present invention, as shown in Fig. 2 and Fig. 3, a bone defect filling scaffold structure is provided, comprising a multi-layer cylindrical base layer 10 and interlayer connecting rods 20, the cylindrical base layer 10 has a mesh structure, multiple Layers of cylindrical bases 10 are nested layer by layer to allow endogenous cells to migrate along the radial, axial and circumferential directions of the multi-layered cylindrical bases 10 when the bone defect filling scaffold structure is implanted into the bone defect; interlayer connecting rods 20 is arranged between two adjacent layers of cylindrical base layers 10, and is used for connecting and fixing the multiple layers of cylindrical base layers 10 to each other.
应用本发明实施例的骨缺损填充支架结构，包括：多层筒状基层10和层间连接杆20，筒状基层10上具有网孔结构，多层筒状基层10逐层嵌套设置以在骨缺损填充支架结构植入骨缺损位置时使内源性细胞沿多层筒状基层10的径向、轴向以及周向迁移；层间连接杆20设置在相邻的两层筒状基层10之间，用于将多层筒状基层10相互连接固定。本发明的骨缺损填充支架结构减少了界壁遮挡，能够使内源性细胞沿多个方向自由迁移，加速细胞的浸润速度和数量，解决了现有技术中的支架结构存在界壁遮挡而影响细胞的浸润速度和数量的问题。The bone defect filling stent structure applying the embodiment of the present invention includes: a multi-layer cylindrical base layer 10 and an interlayer connecting rod 20, the cylindrical base layer 10 has a mesh structure, and the multi-layer cylindrical base layer 10 is nested layer by layer so that When the bone defect filling scaffold structure is implanted in the bone defect, endogenous cells migrate along the radial, axial and circumferential directions of the multi-layer cylindrical base layer 10; Between them, it is used to connect and fix the multi-layer cylindrical base layers 10 to each other. The bone defect filling scaffold structure of the present invention reduces the shielding of the boundary wall, enables the free migration of endogenous cells in multiple directions, accelerates the infiltration speed and quantity of the cells, and solves the problem caused by the shielding of the boundary wall in the scaffold structure in the prior art. The speed and quantity of cell infiltration.
具体实施时，筒状基层10包括：多个环形圈11和多根环间连接杆12，各个环形圈11的直径和粗细均相同，多个环形圈11沿其轴心线方向相互间隔设置，每根环间连接杆12沿环形圈11的轴向延伸设置，多根环间连接杆12沿环形圈11周向相互间隔一定的间距布置并与多个环形圈11相互连接，各个环形圈11与各根环间连接杆12相互交错以形成筒状基层10的网孔结构。During specific implementation, the cylindrical base layer 10 includes: a plurality of annular rings 11 and a plurality of inter-annular connecting rods 12, the diameter and thickness of each annular ring 11 are the same, and the plurality of annular rings 11 are arranged at intervals along the direction of the axis line. Each inter-ring connecting rod 12 is arranged along the axial extension of the annular ring 11, and a plurality of inter-ring connecting rods 12 are arranged at a certain distance from each other along the circumferential direction of the annular ring 11 and are connected with a plurality of annular rings 11. Each annular ring 11 Interlaced with each inter-ring connecting rod 12 to form a mesh structure of the cylindrical base layer 10 .
为了保证网孔结构的形状和大小均相同且分布均匀，进一步地，各个环形圈11之间相互平行且各个环形圈11的轴心线共线，多个环形圈11之间的间距相等；各根环间连接杆12之间相互平行且各根环间连接杆12之间的间距相等。从而使筒状基层10的网孔结构形状和大小均相同，且所有网孔结构呈矩阵状均匀布置。In order to ensure that the shape and size of the mesh structure are the same and evenly distributed, further, each annular ring 11 is parallel to each other and the axis lines of each annular ring 11 are collinear, and the spacing between a plurality of annular rings 11 is equal; The connecting rods 12 between the root rings are parallel to each other and the distance between the connecting rods 12 between the root rings is equal. Therefore, the shape and size of the mesh structure of the tubular base layer 10 are the same, and all the mesh structures are evenly arranged in a matrix.
筒状基层10的环形圈11和环间连接杆12以及层间连接杆20的规格大小以及数量均可根据实际情况调整，从而构建不同密度、不同孔隙率的支架结构。The size and quantity of the annular ring 11 of the cylindrical base layer 10, the inter-annular connecting rods 12 and the interlayer connecting rods 20 can be adjusted according to the actual situation, so as to construct support structures with different densities and porosities.
当骨缺损填充支架结构植入骨缺损位置时，内源性细胞首先沿骨缺损填充支架结构的径向通过筒状基层10上的网孔结构住逐层进入骨缺损填充支架结构，与此同时，内源性细胞在到达相邻的两层筒状基层10后会沿骨缺损填充支架结构的轴向和周向在层间迁移生长并最终迁移生长到骨缺损填充支架结构的中心以将整个骨缺损填充支架结构内部的空隙全部填充满，该结构增大了与组织的接触面积，从而有效提高细胞的浸润速度。When the bone defect filling scaffold structure is implanted into the bone defect position, endogenous cells first pass through the mesh structure on the cylindrical base layer 10 along the radial direction of the bone defect filling scaffold structure and enter the bone defect filling scaffold structure layer by layer, at the same time , endogenous cells will migrate and grow between the layers along the axial and circumferential directions of the bone defect filling scaffold structure after reaching the adjacent two-layer cylindrical base layer 10, and finally migrate and grow to the center of the bone defect filling scaffold structure to The gaps inside the bone defect filling scaffold structure are all filled, and the structure increases the contact area with the tissue, thereby effectively increasing the cell infiltration speed.
为了增强本实施例的骨缺损填充支架结构的整体稳定性，进一步地，层间连接杆20为多根，多根层间连接杆20沿环形圈11周向间隔设置和/或多根层间连接杆20沿环形圈11轴向间隔设置；其中，每根层间连接杆20与其中一个环形圈11共面；且，每根层间连接杆20与其中一根环间连接杆12或者沿环形圈11的径向相对的两根环间连接杆12相交，从而有效减小层间连接杆20对内源性细胞迁移阻碍的作用，加速细胞的迁移浸润速度和数量。In order to enhance the overall stability of the bone defect filling scaffold structure of this embodiment, further, there are multiple interlayer connecting rods 20, and multiple interlayer connecting rods 20 are arranged at intervals along the circumferential direction of the annular ring 11 and/or multiple interlayer connecting rods The connecting rods 20 are arranged axially at intervals along the annular ring 11; wherein, each interlayer connecting rod 20 is coplanar with one of the annular rings 11; The two radially opposite inter-annular connecting rods 12 of the annular ring 11 intersect, thereby effectively reducing the effect of the interlayer connecting rods 20 on endogenous cell migration, and accelerating the migration and infiltration speed and quantity of cells.
进一步地，本实施例的骨缺损填充支架结构由磷酸三钙、羟基磷灰石、壳聚糖、胶原蛋白的混合材料采用3D打印技术制成，其中上述材料的混合比例为3：1：1：1。上述材料为可降解材料，在植入骨缺损位置后会逐渐降解，随之被迁移声场的组织细胞替代，最终达到修复缺损器官的目的。本实施例的骨缺损填充支架结构在具体制造过程中采用上述混合材料通过3D打印的方式由内层向外层逐层打印，从而打印成一体式的支架结构。Further, the bone defect filling scaffold structure of this embodiment is made of a mixed material of tricalcium phosphate, hydroxyapatite, chitosan, and collagen using 3D printing technology, wherein the mixing ratio of the above materials is 3:1:1 :1. The above-mentioned materials are degradable materials, which will gradually degrade after being implanted in the bone defect, and then be replaced by tissue cells that migrate to the sound field, and finally achieve the purpose of repairing the defect organ. The bone defect filling scaffold structure of this embodiment is printed layer by layer from the inner layer to the outer layer by using the above-mentioned mixed material in the specific manufacturing process, so as to print into an integrated scaffold structure.
为了提高支架结构的生物活性，使细胞容易迁移和附着，进一步地，骨缺损填充支架结构中添加有以下各种组织修复因子的至少之一：骨形态发生蛋白(BMP)、血管内皮生长因子(VEGF)、成纤维细胞生长因子(FGF)、转化生长因子-β(TGF-β)、胶原、富血小板纤维蛋白(PRF)、富血小板血浆(PRP)。In order to improve the bioactivity of the scaffold structure and make the cells easy to migrate and attach, further, at least one of the following tissue repair factors is added to the bone defect filling scaffold structure: bone morphogenetic protein (BMP), vascular endothelial growth factor ( VEGF), fibroblast growth factor (FGF), transforming growth factor-β (TGF-β), collagen, platelet-rich fibrin (PRF), platelet-rich plasma (PRP).
骨形态发生蛋白可诱导机体间充质干细胞分化为骨、软骨、韧带、肌腱和神经组织；血管内皮生长因子能够诱导血管新生；成纤维细胞生长因子能够促进新血管形成，并参与组织修复；转化生长因子-β能够调节细胞生长和分化；胶原能够介导细胞迁移和发育；富血小板纤维蛋白或富血小板血浆中富含多种生长因子，能够促进骨损伤修复。Bone morphogenetic protein can induce mesenchymal stem cells to differentiate into bone, cartilage, ligament, tendon and nerve tissue; vascular endothelial growth factor can induce angiogenesis; fibroblast growth factor can promote new blood vessel formation and participate in tissue repair; transformation Growth factor-β can regulate cell growth and differentiation; collagen can mediate cell migration and development; platelet-rich fibrin or platelet-rich plasma is rich in various growth factors, which can promote bone damage repair.
本实施例的骨缺损填充支架结构可以通过外科手术植入缺损部位，替代缺损组织器官，具体地，如图4所示，在手术过程中，通过固定支板40将缺损的自体骨30的两端固定，随后根据缺损处的形状将本实施例的支架结构50的外形加工成与缺损处的形状相匹配的外形，随后将本实施例的支架结构50植入缺损部位即可。The bone defect filling scaffold structure of this embodiment can be surgically implanted into the defect site to replace the defect tissues and organs. Specifically, as shown in FIG. The end is fixed, and then the shape of the stent structure 50 of this embodiment is processed to match the shape of the defect according to the shape of the defect, and then the stent structure 50 of this embodiment is implanted in the defect.
由于本实施例的支架结构50有一定的孔隙，内源性细胞可以沿着孔隙由外向内、层间向上、向下、向左、向右5个方向迁移至支架结构的中心,增加了与组织的接触面积，从而提高细胞浸润速度，支架结构50随之逐渐被降解，直至完全被新生组织替代，达到修复缺损器官的目的；另外，该支架结构可以复合多种生长因子，可提高其生物活性，利于细胞附着和迁移；最后，该支架结构的孔径、孔隙率可调，可打印成各种规格的组织器官，极大的扩展了该结构的应用范围。Since the scaffold structure 50 of this embodiment has certain pores, endogenous cells can migrate to the center of the scaffold structure in five directions along the pores from outside to inside, between layers upward, downward, leftward, and rightward, increasing the The contact area of the tissue can be increased to increase the speed of cell infiltration, and the scaffold structure 50 will be gradually degraded until it is completely replaced by new tissue, so as to achieve the purpose of repairing the defective organ; in addition, the scaffold structure can be compounded with a variety of growth factors, which can improve its biological function. Activity, which is conducive to cell attachment and migration; finally, the pore size and porosity of the scaffold structure are adjustable, and it can be printed into tissues and organs of various specifications, which greatly expands the application range of the structure.
本实施例的骨缺损填充支架结构的孔隙紧结构靠外围组织,消除了传统打印结构的界壁阻挡，同时具有良好的生物活性，植入体内后，可以迅速促进内源性细胞浸润进而修复缺损组织器官。The pores of the bone defect filling scaffold structure in this example are close to the peripheral tissue, which eliminates the boundary barrier of the traditional printing structure, and has good biological activity. After implanting in the body, it can quickly promote the infiltration of endogenous cells and repair the defect. tissues and organs.
以上仅是本发明的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以做出若干改进和润饰，这些改进和润饰也应视为本发明的保护范围。The above are only preferred embodiments of the present invention, and it should be pointed out that for those of ordinary skill in the art, some improvements and modifications can also be made without departing from the principle of the present invention, and these improvements and modifications should also be considered Be the protection scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711417123.5ACN108158697A (en) | 2017-12-25 | 2017-12-25 | bone defect filling bracket structure |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711417123.5ACN108158697A (en) | 2017-12-25 | 2017-12-25 | bone defect filling bracket structure |
| Publication Number | Publication Date |
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| CN108158697Atrue CN108158697A (en) | 2018-06-15 |
| Application Number | Title | Priority Date | Filing Date |
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| CN201711417123.5APendingCN108158697A (en) | 2017-12-25 | 2017-12-25 | bone defect filling bracket structure |
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| RJ01 | Rejection of invention patent application after publication | Application publication date:20180615 |