技术领域technical field
本发明涉及医疗诊断机械技术领域，具体来说，是一种可穿戴式的智能尿检系统。The invention relates to the technical field of medical diagnostic machinery, specifically, a wearable intelligent urine testing system.
背景技术Background technique
在医院、养老机构或家庭中，大多数医疗工作者常常使用试纸条对疾病进行初步筛查，例如西门子的Multistix 10SG和拜耳的Multistixor，这在临床疾病的初筛过程中扮演着重要角色。但是对(部分)失能老人和行动不变的人而言，采用试纸条的方法会存在极大的不便利，对这部分人而言，他们常常佩戴尿不湿，因此将尿不湿与试纸条结合似乎成为一种体液检测疾病有效的方法，且这种体液采集方式具有无痛和便携的特点。In hospitals, nursing homes or families, most medical workers often use test strips for initial screening of diseases, such as Siemens' Multistix 10SG and Bayer's Multistixor, which play an important role in the initial screening of clinical diseases. However, for (partial) disabled old people and people with constant actions, there will be great inconvenience in the method of using test strips. For this part of people, they often wear diapers, so they will use diapers Combining with test strips seems to be an effective way to detect diseases in body fluids, and this method of body fluid collection is painless and portable.
专利US 9131893B2健康诊断系统和方法，将试纸条贴附在尿不湿外侧，并用智能手机301APP对结果进行分析，该方法将测试的指标增加到了12个，但是其中的试纸条附着在尿不湿内，由于尿不湿佩戴到身上一定时间后，无法保证试纸条长时间稳定的颜色，且二次甚至多次撒尿对颜色的判断的影响并未给出定论。In the patent US 9131893B2 health diagnosis system and method, the test strip is attached to the outside of the diaper, and the result is analyzed with the smart phone 301APP. This method increases the test indicators to 12, but the test strip is attached to the urine. In the non-wet, after wearing the diaper for a certain period of time, it is impossible to guarantee the long-term stable color of the test strip, and the influence of the second or even multiple urination on the judgment of the color has not been conclusively given.
专利US 9131893B2提出了一种基于尿不湿的样本收集和计算系统，用于疾病的诊断，但该设备没有自锁系统，二次进尿的影响并未阐述。瑞士Swiss Med Wkly公司开发出了一种基于尿不湿的产品Tena U test，该产品通过设备的自锁模块将试纸条密封在尿不湿中一个特定的固定的环境，用于尿路感染的初步筛查，尽管其有效期能达到24小时，但是该产品只是定性检测尿液中的白细胞和亚硝酸盐，其功能较单一，并不能满足临床中尿液生理指标的筛查需求。Patent US 9131893B2 proposes a diaper-based sample collection and calculation system for disease diagnosis, but the device does not have a self-locking system, and the impact of secondary urine intake is not explained. The Swiss Med Wkly company in Switzerland has developed a diaper-based product Tena U test, which seals the test strip in a specific fixed environment in the diaper through the self-locking module of the device, and is used for urinary tract infection Although its validity period can reach 24 hours, this product only qualitatively detects white blood cells and nitrite in urine, and its function is relatively simple, which cannot meet the screening needs of clinical urine physiological indicators.
专利CN105929148B公开了一种基于纸尿裤的被动式体液样本筛查与检验装置及使用方法，在该装置中，尿液从收集层进入到测试层中的路径网络中，通过路径网络中水平设置的亲水通道进入到生物标志物反应模块中，从而与生物标志物反应模块中的试剂进行反应。该装置中，尿液要先经过自锁模块中的膨胀体吸收后，再进入到亲水性通道中，很可能导致生物标志物反应模块还没被完全湿润自锁模块就自锁，导致生物标志物反应模块不能显色反应；同时该亲水性通道是水平设置的，生物标志物反应模块位于亲水性通道的末端，也可能会导致尿液不能流到生物标志物反应模块，或者不能均匀湿润生物标志物反应模块，导致反应不准确；该装置只能定性的反应检测结果，无法给出定量的反应结果。Patent CN105929148B discloses a passive body fluid sample screening and testing device based on diapers and its use method. In this device, urine enters the path network in the test layer from the collection layer, and passes through the horizontally arranged hydrophilic The channel enters the biomarker reaction module to react with the reagents in the biomarker reaction module. In this device, the urine must first be absorbed by the expansion body in the self-locking module, and then enter the hydrophilic channel, which may cause the biomarker reaction module to self-lock before it is completely wetted, resulting in biological The marker reaction module cannot develop a color reaction; at the same time, the hydrophilic channel is set horizontally, and the biomarker reaction module is located at the end of the hydrophilic channel, which may also cause urine to fail to flow to the biomarker reaction module, or cannot Evenly wet the biomarker reaction module, resulting in inaccurate reaction; the device can only respond qualitatively to the test results, but cannot give quantitative reaction results.
发明内容Contents of the invention
本发明目的是旨在提供了一种可穿戴式智能尿检系统，在不超额润湿的情况下，少量的尿液就能保证每一块生物标志物反应模块都能得到完全的润湿，保证反应结果的准确性，同时还可以通过智能检测软件对反应结果进行定性和定量的分析，使得检测结果更加的精准。The purpose of the present invention is to provide a wearable intelligent urine testing system, in the case of no excess wetting, a small amount of urine can ensure that each biomarker reaction module can be completely wetted, ensuring the reaction The accuracy of the results, and at the same time, the qualitative and quantitative analysis of the reaction results can be carried out through intelligent detection software, making the detection results more accurate.
为实现上述技术目的，本发明采用的技术方案如下：For realizing above-mentioned technical purpose, the technical scheme that the present invention adopts is as follows:
一种可穿戴式智能尿检系统，包括收集层、测试层，所述测试层包括测试层本体、镶嵌在所述测试层本体上的若干个生物标志物反应模块，还包括用于定性或者定量分析生物标志物反应模块反应结果的智能检测软件，所述收集层包括自锁模块、与所述生物标志物连通的收集通道，所述自锁模块包括自锁开关、膨胀体，所述收集通道竖直的开设在所述膨胀体上，所述收集通道的吸水性大于所述膨胀体的吸水性；所述测试层由疏水材料制成。A wearable smart urine testing system, including a collection layer and a test layer, the test layer includes a test layer body, several biomarker response modules embedded on the test layer body, and a qualitative or quantitative analysis module. Intelligent detection software for the reaction results of the biomarker response module, the collection layer includes a self-locking module, a collection channel connected with the biomarker, the self-locking module includes a self-locking switch, an expansion body, and the collection channel is vertical The water absorption of the collection channel is greater than that of the expansion body; the test layer is made of hydrophobic material.
采用上述技术方案的发明，收集通道的吸水性大于膨胀体的吸水性，使得膨胀体的吸水速率小于收集通道的速率，从而在膨胀体膨胀将自锁开关关闭时，保证有足够的尿液被生物标志物反应模块所吸收，保证生物标志物反应模块的足够润湿；收集通道竖直的开设在膨胀体上这种结构课为尿液提供毛细作用，同时再加上尿液其自身的重力作用以及收集通道的吸水性能，使得尿液能顺利流入到每一块生物标志物反应模块，进一步保证生物标志物反应模块的足够润湿，保证结果的准确性；疏水材料制成的测试层保证了各个生物标志物反应模块之间互不干扰，进一步保证反应结果的准确性；通过智能检测软件对反应结果进行定性和定量的分析，可提高结果的精确性。With the invention of the above technical solution, the water absorption of the collection channel is greater than that of the expansion body, so that the water absorption rate of the expansion body is lower than the rate of the collection channel, so that when the expansion body expands and the self-locking switch is turned off, enough urine is guaranteed to be collected. The biomarker reaction module is absorbed to ensure sufficient wetting of the biomarker reaction module; the collection channel is vertically opened on the expansion body. This structure provides capillary action for the urine, and at the same time, the gravity of the urine itself The function and the water absorption performance of the collection channel enable the urine to flow smoothly into each biomarker reaction module, further ensuring sufficient wetting of the biomarker reaction module and the accuracy of the results; the test layer made of hydrophobic materials ensures Each biomarker reaction module does not interfere with each other to further ensure the accuracy of the reaction results; qualitative and quantitative analysis of the reaction results through intelligent detection software can improve the accuracy of the results.
作为本发明一种可穿戴式智能尿检系统的一种优选，所述收集通道里填充有导流物质，所述导流物质的吸水性大于所述膨胀体的吸水性。As a preferred embodiment of the wearable intelligent urine testing system of the present invention, the collecting channel is filled with a diversion substance, and the water absorption of the diversion substance is greater than that of the expansion body.
导流物质的加入可增大毛细作用，加快收集通道的尿液导流速度，保证尿液可以足够润湿生物标志物反应模块。最优的，导流物质为无纺布或吸墨纸中的一种或者多种。The addition of the diversion substance can increase the capillary action, accelerate the urine diversion speed of the collection channel, and ensure that the urine can sufficiently wet the biomarker reaction module. Optimally, the diversion material is one or more of non-woven fabric or ink-absorbing paper.
作为本发明一种可穿戴式智能尿检系统的另一种优选，在所述膨胀体的上表面没有开设收集通道的区域覆盖一层薄膜，所述薄膜的吸水性小于所述膨胀体的吸水性。As another preference of the wearable intelligent urine testing system of the present invention, a film is covered on the upper surface of the expansion body where no collection channel is opened, and the water absorption of the film is lower than that of the expansion body. .
薄膜可以延缓膨胀体对尿液的吸收，保证每一块生物标志物反应模块的足够润湿。优选的，该薄膜为玻璃纸或聚甲基丙烯酸甲酯；膨胀体可为支链淀粉、超吸水性聚丙烯树脂、聚马来酸、HP(MA-VAC-MMA)、HP(MA-VAC)及其混合物。The film can delay the absorption of urine by the expansion body, ensuring sufficient wetting of each biomarker response module. Preferably, the film is cellophane or polymethyl methacrylate; the expansion body can be pullulan, superabsorbent polypropylene resin, polymaleic acid, HP (MA-VAC-MMA), HP (MA-VAC) and mixtures thereof.
作为本发明一种可穿戴式智能尿检系统的又一种优选，所述收集通道位于所述生物标志物反应模块的正上方。As another preference of the wearable smart urine testing system of the present invention, the collection channel is located directly above the biomarker reaction module.
该收集通道可使尿液快速直达生物标志物反应模块的中心，并使尿液从中心往外扩散，保证反应颜色的均匀，为定量分析的准确性提供基础。The collection channel can make the urine quickly reach the center of the biomarker reaction module, and make the urine diffuse from the center to ensure uniform reaction color and provide a basis for the accuracy of quantitative analysis.
作为本发明一种可穿戴式智能尿检系统的再一种优选，所述收集层还包括由疏水材料制成的长方体框架，所述膨胀体、收集通道、测试层均位于所述框架内，所述收集通道由所述框架与所述膨胀体围设而成。As another preference of the wearable intelligent urine testing system of the present invention, the collection layer further includes a cuboid frame made of hydrophobic material, the expansion body, the collection channel, and the test layer are all located in the frame, so The collection channel is surrounded by the frame and the expansion body.
疏水材料制成的长方体框架将膨胀体、收集通道、测试层均包裹在其内，在生物标志物反应模块与尿液反应以后，被锁在一个密闭的环境中，这个密闭的环境可组织反应过后的试剂块与空气产生副反应，于此同时避免了颜色水合底物的蒸发。The cuboid frame made of hydrophobic material wraps the expansion body, the collection channel, and the test layer. After the biomarker reaction module reacts with urine, it is locked in an airtight environment. This airtight environment can organize the reaction The later reagent block reacts side-by-side with the air while avoiding evaporation of the color hydration substrate.
作为本发明一种可穿戴式智能尿检系统的另一种优选，所述收集通道包括竖直段和用于覆盖所述生物标志物反应模块的延伸段，所述竖直段和延伸段内均填充有导流物质。As another preference of the wearable smart urine testing system of the present invention, the collection channel includes a vertical section and an extension section for covering the biomarker reaction module, and both the vertical section and the extension section are Filled with a diversion substance.
延伸段保证在此种结构下，尿液能完全均匀润湿生物标志物反应模块。The extension section ensures that under this structure, the urine can completely and evenly wet the biomarker reaction module.
作为本发明一种可穿戴式智能尿检系统的另一种优选，所述智能检测软件包括用于采集标准色卡与生物标志物反应模块反应结果的图像采集模块，图像定位模块、图像透视转换模块、特征提取模块、数据处理模块、结果分析模块。As another preference of the wearable intelligent urine testing system of the present invention, the intelligent detection software includes an image acquisition module for collecting the reaction results of the standard color card and the biomarker reaction module, an image positioning module, and an image perspective conversion module , feature extraction module, data processing module, and result analysis module.
最优的，智能检测软件为安装在手机上的智能检测软件，可以利用手机本身的相机来进行图像的采集。Optimally, the intelligent detection software is the intelligent detection software installed on the mobile phone, which can use the camera of the mobile phone itself to collect images.
作为本发明一种可穿戴式智能尿检系统的又一种优选，还包括位于最表层的、由亲水材料制成的表面过滤层，所述表面过滤层边缘超出所述收集层，所述标准色卡粘贴在所述表面过滤层超出所述收集层那部分区域的底面。As another preference of the wearable intelligent urine testing system of the present invention, it also includes a surface filter layer made of hydrophilic material on the outermost layer, the edge of the surface filter layer exceeds the collection layer, and the standard The color card is pasted on the bottom surface of the area where the surface filter layer exceeds the collection layer.
将标准色卡贴在表面过滤层超出所述收集层那部分区域的底面，可同时采集标准色卡与生物标志物反应模块反应颜色的图像，同时也方便对采集的图像进行定位和特征提取。Sticking the standard color card on the bottom surface of the part of the surface filter layer beyond the collection layer can simultaneously collect images of the standard color card and the reaction color of the biomarker reaction module, and also facilitate the positioning and feature extraction of the collected images.
最优的，标准色卡可以环绕收集层贴在表面过滤层底面，或者贴在收集层的两侧。Optimally, the standard color card can be pasted on the bottom of the surface filter layer around the collection layer, or on both sides of the collection layer.
作为本发明一种可穿戴式智能尿检系统的另一种优选，所述标准色卡的四个角上设置有识别码，用于图像定位模块对图像的定位。最优的，识别码为二维码或者圆点。As another preference of the wearable intelligent urine testing system of the present invention, the four corners of the standard color card are provided with identification codes for positioning the image by the image positioning module. Optimally, the identification code is a two-dimensional code or a dot.
作为本发明一种可穿戴式智能尿检系统的再一种优选，所述图像透视转换模块通过采用尺度不变特征转换(scale-invariant feature transform,sift)、SURF算法、BRISK算法或广义霍夫变换(generalized Hough transform)中的一种算法对图像进行透视转换。As another preference of the wearable intelligent urine testing system of the present invention, the image perspective transformation module adopts scale-invariant feature transform (sift), SURF algorithm, BRISK algorithm or generalized Hough transform An algorithm in (generalized Hough transform) performs a perspective transformation on an image.
作为本发明一种可穿戴式智能尿检系统的另一种优选，所述特征提取模块提取图像中生物标志物反应模块和标准色卡所对应的特征数据，其特征数据为RGB,sRGB,LMS,VonKries LMS，XYZ中的一种。As another preference of the wearable intelligent urine testing system of the present invention, the feature extraction module extracts the feature data corresponding to the biomarker response module and the standard color card in the image, and the feature data are RGB, sRGB, LMS, VonKries LMS, one of XYZ.
作为本发明一种可穿戴式智能尿检系统的又一种优选，所述数据处理模块是基于生物标志物反应模块颜色与所对应的标准色卡的相似度来实现生物标志物定性和半定量的判断，相似度最高的标准色卡所对应的水平为尿液中该生物标志物的水平，图像相似度的比较采用线性判别(linear discriminant analysis,LDA)、二次判别(quadraticdiscriminant analysis，QDA)或K均值聚类法(k-means clustering)中的一种方法。As another preference of the wearable intelligent urine testing system of the present invention, the data processing module is based on the similarity between the color of the biomarker response module and the corresponding standard color card to realize the qualitative and semi-quantitative detection of biomarkers Judgment, the level corresponding to the standard color card with the highest similarity is the level of the biomarker in urine, and the image similarity is compared using linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) or A method in k-means clustering.
智能检测软件用于提取生物标志物反应模块和标准色卡上的色标的特征颜色，图像处理的过程包括特征数据提取和图像相似度比较，所述的特征数据采用的是颜色空间，可以是RGB,sRGB,LMS,Von Kries LMS或XYZ，在特征数据提取之前可采用尺度不变特征转换(scale-invariant feature transform,sift)、SURF、BRISK或广义霍夫变换(generalized Hough transform)等算法对图片进行预处理。生物标志物定性和半定量判断方法是基于生物标志物反应模块颜色与所对应的标准色卡的相似度，相似度最高的标准色块所对应的水平为尿液中该生物标志物的水平，图像相似度的比较采用线性判别(linear discriminant analysis,LDA)、二次判别(quadratic discriminant analysis，QDA)或K均值聚类法(k-means clustering)。The intelligent detection software is used to extract the characteristic color of the color standard on the biomarker reaction module and the standard color card. The process of image processing includes feature data extraction and image similarity comparison. The feature data uses a color space, which can be RGB , sRGB, LMS, Von Kries LMS or XYZ, before feature data extraction, algorithms such as scale-invariant feature transform (sift), SURF, BRISK or generalized Hough transform (generalized Hough transform) can be used to image Do preprocessing. The qualitative and semi-quantitative judgment methods of biomarkers are based on the similarity between the color of the biomarker response module and the corresponding standard color card. The level corresponding to the standard color block with the highest similarity is the level of the biomarker in the urine. The comparison of image similarity adopts linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) or K-means clustering (k-means clustering).
本发明在不超额润湿的情况下，能保证每一块生物标志物反应模块都能得到完全的润湿，保证反应结果的准确性，同时还可以对反应结果进行定性和定量的分析，使得检测结果更加的精准。The present invention can ensure that each biomarker reaction module can be completely wetted without excessive wetting, ensuring the accuracy of the reaction results, and can also perform qualitative and quantitative analysis on the reaction results, so that the detection The result is more precise.
本发明的另一目的是提供一种可穿戴式智能尿检系统的尿检方法，包括如下步骤：Another object of the present invention is to provide a urine testing method of a wearable intelligent urine testing system, comprising the following steps:
1)图像采集，将本装置从尿不湿中取出来，通过图像采集模块对标准色卡与生物标志物反应模块反应结果进行图像采集；1) Image acquisition, the device is taken out from the diaper, and image acquisition is performed on the reaction results of the standard color card and the biomarker reaction module through the image acquisition module;
2)图像定位与透视转换，图像定位模块利用识别码进行定位识别，图像透视转换模块采用尺度不变特征转换(scale-invariant feature transform,sift)、SURF、BRISK或广义霍夫变换(generalized Hough transform)中的一种算法对图像进行透视转换；2) Image positioning and perspective transformation, the image positioning module uses identification codes for positioning and recognition, and the image perspective transformation module uses scale-invariant feature transform (scale-invariant feature transform, sift), SURF, BRISK or generalized Hough transform (generalized Hough transform) An algorithm in ) performs perspective transformation on the image;
3)特征提取，采集图像中反应色块和标准色卡所对应的特征数据，其特征数据可以是RGB,sRGB,LMS,Von Kries LMS或XYZ中的一种；3) Feature extraction, collect the feature data corresponding to the reaction color block and the standard color card in the image, and the feature data can be one of RGB, sRGB, LMS, Von Kries LMS or XYZ;
4)数据处理，生物标志物定性和半定量判断方法是基于生物标志物反应模块颜色与所对应的标准色卡的相似度，相似度最高的标准色块所对应的水平为尿液中该生物标志物的水平，图像相似度的比较采用线性判别(linear discriminant analysis,LDA)、二次判别(quadratic discriminant analysis，QDA)或K均值聚类法(k-means clustering)中的一种；4) Data processing, biomarker qualitative and semi-quantitative judgment methods are based on the similarity between the color of the biomarker response module and the corresponding standard color card, and the level corresponding to the standard color block with the highest similarity is the level of the biological marker in the urine. One of linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) or K-means clustering was used to compare the level of markers and image similarity;
5)结果分析。5) Analysis of results.
附图说明Description of drawings
本发明可以通过附图给出的非限定性实施例进一步说明；The invention can be further illustrated by the non-limiting examples given in the accompanying drawings;
图1为实施例1中一种可穿戴式智能尿检系统的立体分解图；Fig. 1 is a three-dimensional exploded view of a wearable smart urine testing system in Example 1;
图2为实施例1中一种可穿戴式智能尿检系统的结构示意图；Fig. 2 is the structural representation of a kind of wearable intelligent urine detection system in embodiment 1;
图3为实施例1中自锁开关的另一种结构示意图；Fig. 3 is another kind of structural representation of self-locking switch in embodiment 1;
图4为实施例1中收集通道中加入导流物质后的尿检系统的结构示意图；4 is a schematic structural view of the urine testing system after adding a diversion substance to the collection channel in Example 1;
图5为实施例2中一种可穿戴式智能尿检系统中的结构示意图；Fig. 5 is a schematic structural view of a wearable smart urine testing system in Embodiment 2;
图6为实施例3中一种可穿戴式智能尿检系统的结构示意图；Fig. 6 is a schematic structural diagram of a wearable smart urine testing system in embodiment 3;
图7为一种可穿戴式智能尿检系统检测方法的流程图；Fig. 7 is a flow chart of a detection method of a wearable intelligent urine detection system;
图8为标准色卡的一种位置关系图；Fig. 8 is a kind of position relationship diagram of standard color card;
图9为标准色卡的另一种位置关系图；Fig. 9 is another position relationship diagram of the standard color card;
主要元件符号说明如下：The main component symbols are explained as follows:
表面过滤层1、标准色卡2、识别码21、收集层3、框架31、入口311、自锁模块32、自锁开关321、膨胀体322、收集通道33、导流物质331、竖直段332、延伸段333、测试层4、测试层本体41、生物标志物反应模块42。Surface filter layer 1, standard color card 2, identification code 21, collection layer 3, frame 31, inlet 311, self-locking module 32, self-locking switch 321, expansion body 322, collection channel 33, diversion material 331, vertical section 332 , extension section 333 , test layer 4 , test layer body 41 , biomarker response module 42 .
具体实施方式Detailed ways
为了使本领域的技术人员可以更好地理解本发明，下面结合附图和实施例对本发明技术方案进一步说明。In order to enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be further described below in conjunction with the accompanying drawings and embodiments.
实施例1Example 1
如图1和图2所示，一种可穿戴式智能尿检系统，包括位于最表层的由亲水材料制成的表面过滤层1，粘贴在表面过滤层1底面的标准色卡2，收集层3，测试层4，用于定性或者定量分析生物标志物反应模块反应结果的智能检测软件。As shown in Figures 1 and 2, a wearable smart urine testing system includes a surface filter layer 1 made of a hydrophilic material located on the outermost layer, a standard color card 2 pasted on the bottom of the surface filter layer 1, and a collection layer 3. Testing layer 4, intelligent detection software for qualitative or quantitative analysis of the response results of the biomarker response module.
表面过滤层1由无纺布或棉组成，其能有效透过尿液成分且能有效过滤尿不湿中的粪便残渣，与此同时，能使佩戴尿不湿的人更加舒适。表面过滤层1的边缘延伸出框架31的顶面，标准色卡2粘贴在延伸出来的那部分区域上，可以是围绕收集层3粘贴如图8所示，也可以是粘贴在收集层3的两侧，图9所示。The surface filter layer 1 is made of non-woven fabric or cotton, which can effectively permeate urine components and effectively filter fecal residues in the diaper, and at the same time, can make people wearing the diaper more comfortable. The edge of the surface filter layer 1 extends out of the top surface of the frame 31, and the standard color card 2 is pasted on the extended part of the area, which can be pasted around the collection layer 3 as shown in Figure 8, or it can be pasted on the collection layer 3. Both sides, as shown in Figure 9.
收集层3包括由透明塑料制成的长方体框架31，自锁模块32，与所述生物标志物反应模块42连通的收集通道33；其中自锁模块32、收集通道33、测试层4均位于框架31内。框架31的顶部中心处开设有尿液入口311。自锁模块32包括安装在尿液入口311处的自锁开关321、以及设置在框架31内部的膨胀体322，通过膨胀体322吸收尿液膨胀将自锁开关321关闭达到自锁的目的，如图2和图3所示，自锁开关321可以与入口311转动连接，也可以活动的设置在入口311处。收集通道33竖直设置，由所述框架31与所述膨胀体322围设而成，直接与生物标志物反应模块42连通，这种结构可为尿液提供毛细作用，使得收集通道33的吸水性大于膨胀体322的吸水性，使尿液渗透进入生物标志物反应模块42。如图4所示，为了进一步保证尿液的导流速度，在收集通道33中填充导流物质331，比如无纺布、吸墨纸等。为了避免发生生物标志物反应模块42还没润湿完全而发生自锁的情况，在所述膨胀体322的上表面没有开设收集通道的区域覆盖一层薄膜，所述薄膜的吸水性小于所述膨胀体322的吸水性，该薄膜的材料可以是玻璃纸或聚甲基丙烯酸甲酯。The collection layer 3 includes a rectangular parallelepiped frame 31 made of transparent plastic, a self-locking module 32, and a collection channel 33 communicated with the biomarker reaction module 42; wherein the self-locking module 32, the collection channel 33, and the test layer 4 are all located in the frame. within 31. A urine inlet 311 is opened at the top center of the frame 31 . The self-locking module 32 includes a self-locking switch 321 installed at the urine inlet 311, and an expansion body 322 arranged inside the frame 31. The expansion body 322 absorbs the expansion of urine and closes the self-locking switch 321 to achieve the purpose of self-locking, such as As shown in FIG. 2 and FIG. 3 , the self-locking switch 321 can be rotatably connected with the entrance 311 , and can also be movably arranged at the entrance 311 . The collection channel 33 is vertically arranged, surrounded by the frame 31 and the expansion body 322, and directly communicates with the biomarker reaction module 42. This structure can provide capillary action for urine, so that the water absorption of the collection channel 33 The water absorption property of the expansion body 322 is greater than that of the expansion body 322, so that the urine penetrates into the biomarker reaction module 42. As shown in FIG. 4 , in order to further ensure the diversion velocity of the urine, the collecting channel 33 is filled with a diversion material 331 , such as non-woven fabric, blotting paper and the like. In order to avoid the self-locking situation that the biomarker reaction module 42 is not fully wetted, a layer of film is covered on the upper surface of the expansion body 322 where there is no collection channel, and the water absorption of the film is lower than that of the The water absorption of the expansion body 322, the material of the film can be cellophane or polymethyl methacrylate.
所述测试层4包括测试层本体41、镶嵌在所述测试层本体41上的若干个生物标志物反应模块42，测试层本体41由疏水材料制成，位于框架31的最底层。框架31将测试层4包裹在其中，可对其进行保护，生物标志物反应模块42在与尿液中的生物标志物反应之后，所有的试剂块被锁在一个密闭的环境，这个密闭的环境可组织反应过后的试剂块与空气产生副反应，于此同时避免了颜色水合底物的蒸发。The test layer 4 includes a test layer body 41 and several biomarker reaction modules 42 embedded in the test layer body 41 . The test layer body 41 is made of hydrophobic material and is located at the bottom of the frame 31 . The frame 31 wraps the test layer 4 in it, which can protect it. After the biomarker reaction module 42 reacts with the biomarkers in the urine, all the reagent blocks are locked in a closed environment. This closed environment It can prevent the side reaction of the reacted reagent block with the air, and at the same time avoid the evaporation of the color hydration substrate.
所述智能检测软件包括用于采集标准色卡2与生物标志物反应模块42反应结果的图像采集模块，图像定位模块、图像透视转换模块、特征提取模块、数据处理模块、结果分析模块。The intelligent detection software includes an image acquisition module for collecting the reaction results of the standard color card 2 and the biomarker reaction module 42, an image positioning module, an image perspective conversion module, a feature extraction module, a data processing module, and a result analysis module.
如图8、图9所示，所述标准色卡2的四个角上设置有识别码21，用于图像定位模块对图像的定位。该识别码可以是圆点，也可以是二维码As shown in FIG. 8 and FIG. 9 , the four corners of the standard color card 2 are provided with identification codes 21 for positioning the image by the image positioning module. The identification code can be a dot or a QR code
所述图像透视转换模块通过采用尺度不变特征转换(scale-invariant featuretransform,sift)、SURF算法、BRISK算法或广义霍夫变换(generalized Hough transform)中的一种算法对图像进行透视转换。The image perspective transformation module performs perspective transformation on the image by using an algorithm among scale-invariant feature transform (scale-invariant feature transform, sift), SURF algorithm, BRISK algorithm or generalized Hough transform.
所述特征提取模块提取图像中生物标志物反应模块和标准色卡所对应的特征数据，其特征数据为RGB,sRGB,LMS,Von Kries LMS，XYZ中的一种。The feature extraction module extracts the feature data corresponding to the biomarker response module and the standard color card in the image, and the feature data is one of RGB, sRGB, LMS, Von Kries LMS, and XYZ.
所述数据处理模块是基于生物标志物反应模块颜色与所对应的标准色卡的相似度来实现The data processing module is realized based on the similarity between the color of the biomarker response module and the corresponding standard color card
生物标志物定性和半定量的判断，相似度最高的标准色卡所对应的水平为尿液中该生物标志物的水平，图像相似度的比较采用线性判别(linear discriminant analysis,LDA)、二次判别(quadratic discriminant analysis，QDA)或K均值聚类法(k-meansclustering)中的一种。For the qualitative and semi-quantitative judgment of biomarkers, the level corresponding to the standard color card with the highest similarity is the level of the biomarker in urine, and the image similarity is compared using linear discriminant analysis (LDA), quadratic One of quadratic discriminant analysis (QDA) or k-means clustering.
实施例2Example 2
如图5所示，一种可穿戴式智能尿检系统，包括位于最表层的由亲水材料制成的表面过滤层1，粘贴在表面过滤层1底面的标准色卡2，收集层3，测试层4，用于定性或者定量分析生物标志物反应模块42反应结果的智能检测软件。As shown in Figure 5, a wearable smart urine testing system includes a surface filter layer 1 made of hydrophilic material on the outermost layer, a standard color card 2 pasted on the bottom surface of the surface filter layer 1, a collection layer 3, and a test Layer 4, intelligent detection software for qualitative or quantitative analysis of the response results of the biomarker response module 42 .
表面过滤层1由无纺布或棉组成，其能有效透过尿液成分且能有效过滤尿不湿中的粪便残渣，与此同时，能使佩戴尿不湿的人更加舒适。表面过滤层1的边缘延伸出框架31的顶面，标准色卡2粘贴在延伸出来的那部分区域上，可以是围绕收集层3粘贴如图8所示，也可以是粘贴在收集层3的两侧，图9所示，本实施例采用图8所示的结构。The surface filter layer 1 is made of non-woven fabric or cotton, which can effectively permeate urine components and effectively filter fecal residues in the diaper, and at the same time, can make people wearing the diaper more comfortable. The edge of the surface filter layer 1 extends out of the top surface of the frame 31, and the standard color card 2 is pasted on the extended part of the area, which can be pasted around the collection layer 3 as shown in Figure 8, or it can be pasted on the collection layer 3. Both sides, as shown in FIG. 9 , this embodiment adopts the structure shown in FIG. 8 .
收集层3包括由透明塑料制成的长方体框架31，自锁模块32，与所述生物标志物反应模块42连通的收集通道33；其中自锁模块32、收集通道33、测试层4均位于框架31内。框架31的顶部中心处开设有尿液入口311。自锁模块32包括安装在尿液入口311处的自锁开关321、以及设置在框架31内部的膨胀体322，通过膨胀体322吸收尿液膨胀将自锁开关321关闭达到自锁的目的。收集通道33竖直设置，由所述框架31与所述膨胀体322围设而成，直接与生物标志物反应模块42连通，这种结构可为尿液提供毛细作用，使得收集通道33的吸水性大于膨胀体322的吸水性，使尿液渗透进入生物标志物反应模块42。为了进一步保证尿液的导流速度，在收集通道33中填充导流物质331，比如无纺布、吸墨纸等。为了进一步避免生物标志物反应模块42不能均匀显色反应，收集通道33包括竖直段332和用于覆盖所述生物标志物反应模块42的延伸段333，所述竖直段332和延伸段333内均填充有导流物质331。为了避免发生生物标志物反应模块42还没润湿完全而发生自锁的情况，在所述膨胀体322的上表面没有开设收集通道33的区域覆盖一层薄膜，所述薄膜的吸水性小于所述膨胀体322的吸水性，该薄膜的材料可以是玻璃纸或聚甲基丙烯酸甲酯。The collection layer 3 includes a rectangular parallelepiped frame 31 made of transparent plastic, a self-locking module 32, and a collection channel 33 communicated with the biomarker reaction module 42; wherein the self-locking module 32, the collection channel 33, and the test layer 4 are all located in the frame. within 31. A urine inlet 311 is opened at the top center of the frame 31 . The self-locking module 32 includes a self-locking switch 321 installed at the urine inlet 311 and an expansion body 322 arranged inside the frame 31. The expansion body 322 absorbs urine expansion and closes the self-locking switch 321 to achieve the purpose of self-locking. The collection channel 33 is vertically arranged, surrounded by the frame 31 and the expansion body 322, and directly communicates with the biomarker reaction module 42. This structure can provide capillary action for urine, so that the water absorption of the collection channel 33 The water absorption property of the expansion body 322 is greater than that of the expansion body 322, so that the urine penetrates into the biomarker reaction module 42. In order to further ensure the diversion speed of the urine, the collecting channel 33 is filled with a diversion material 331 , such as non-woven fabric, blotting paper and the like. In order to further prevent the biomarker reaction module 42 from being unable to develop a uniform color reaction, the collection channel 33 includes a vertical section 332 and an extension section 333 for covering the biomarker reaction module 42, the vertical section 332 and the extension section 333 Both are filled with diversion material 331 . In order to avoid the self-locking situation that the biomarker reaction module 42 is not fully wetted, the area where the collection channel 33 is not provided on the upper surface of the expansion body 322 is covered with a layer of film, and the water absorption of the film is less than the required one. For the water absorption of the expansion body 322, the material of the film can be cellophane or polymethyl methacrylate.
所述测试层4包括测试层本体41、镶嵌在所述测试层本体41上的若干个生物标志物反应模块42，测试层本体41由疏水材料制成，位于框架31的最底层。框架31将测试层4包裹在其中，可对其进行保护，生物标志物反应模块42在与尿液中的生物标志物反应之后，所有的试剂块被锁在一个密闭的环境，这个密闭的环境可组织反应过后的试剂块与空气产生副反应，于此同时避免了颜色水合底物的蒸发。The test layer 4 includes a test layer body 41 and several biomarker reaction modules 42 embedded in the test layer body 41 . The test layer body 41 is made of hydrophobic material and is located at the bottom of the frame 31 . The frame 31 wraps the test layer 4 in it, which can protect it. After the biomarker reaction module 42 reacts with the biomarkers in the urine, all the reagent blocks are locked in a closed environment. This closed environment It can prevent the side reaction of the reacted reagent block with the air, and at the same time avoid the evaporation of the color hydration substrate.
所述智能检测软件包括用于采集标准色卡2与生物标志物反应模块42反应结果的图像采集模块，图像定位模块、图像透视转换模块、特征提取模块、数据处理模块、结果分析模块。The intelligent detection software includes an image acquisition module for collecting the reaction results of the standard color card 2 and the biomarker reaction module 42, an image positioning module, an image perspective conversion module, a feature extraction module, a data processing module, and a result analysis module.
如图8、图9所示，所述标准色卡2的四个角上设置有识别码21，用于图像定位模块对图像的定位。As shown in FIG. 8 and FIG. 9 , the four corners of the standard color card 2 are provided with identification codes 21 for positioning the image by the image positioning module.
所述图像透视转换模块通过采用尺度不变特征转换(scale-invariant featuretransform,sift)、SURF算法、BRISK算法或广义霍夫变换(generalized Hough transform)中的一种算法对图像进行透视转换。The image perspective transformation module performs perspective transformation on the image by using an algorithm among scale-invariant feature transform (scale-invariant feature transform, sift), SURF algorithm, BRISK algorithm or generalized Hough transform.
所述特征提取模块提取图像中生物标志物反应模块42和标准色卡2所对应的特征数据，其特征数据为RGB,sRGB,LMS,Von Kries LMS，XYZ中的一种。The feature extraction module extracts the feature data corresponding to the biomarker response module 42 and the standard color card 2 in the image, and the feature data is one of RGB, sRGB, LMS, Von Kries LMS, and XYZ.
所述数据处理模块是基于生物标志物反应模块42颜色与所对应的标准色卡2的相似度来实现生物标志物定性和半定量的判断，相似度最高的标准色卡2所对应的水平为尿液中该生物标志物的水平，图像相似度的比较采用线性判别(linear discriminantanalysis,LDA)、二次判别(quadratic discriminant analysis，QDA)或K均值聚类法(k-means clustering)中的一种。The data processing module realizes the qualitative and semi-quantitative judgment of biomarkers based on the similarity between the color of the biomarker response module 42 and the corresponding standard color card 2, and the level corresponding to the standard color card 2 with the highest similarity is The level of the biomarker in urine and the image similarity were compared using one of linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) or K-means clustering. kind.
实施例3Example 3
如图6所示，一种可穿戴式智能尿检系统，包括位于最表层的由亲水材料制成的表面过滤层1，粘贴在表面过滤层1底面的标准色卡2，收集层3，测试层4，用于定性或者定量分析生物标志物反应模块42反应结果的智能检测软件。As shown in Figure 6, a wearable smart urine testing system includes a surface filter layer 1 made of hydrophilic material on the outermost layer, a standard color card 2 pasted on the bottom surface of the surface filter layer 1, a collection layer 3, and a test Layer 4, intelligent detection software for qualitative or quantitative analysis of the response results of the biomarker response module 42 .
表面过滤层1由无纺布或棉组成，其能有效透过尿液成分且能有效过滤尿不湿中的粪便残渣，与此同时，能使佩戴尿不湿的人更加舒适。表面过滤层1的边缘延伸出框架31的顶面，标准色卡2粘贴在延伸出来的那部分区域上，可以是围绕收集层3粘贴如图8所示，也可以是粘贴在收集层3的两侧，图9所示，本实施例采用图8所示的结构。The surface filter layer 1 is made of non-woven fabric or cotton, which can effectively permeate urine components and effectively filter fecal residues in the diaper, and at the same time, can make people wearing the diaper more comfortable. The edge of the surface filter layer 1 extends out of the top surface of the frame 31, and the standard color card 2 is pasted on the extended part of the area, which can be pasted around the collection layer 3 as shown in Figure 8, or it can be pasted on the collection layer 3. Both sides, as shown in FIG. 9 , this embodiment adopts the structure shown in FIG. 8 .
收集层3包括由透明塑料制成的长方体框架31，自锁模块32，与所述生物标志物反应模块42连通的收集通道33；其中自锁模块32、收集通道33、测试层4均位于框架31内。框架31的顶部中心处开设有尿液入口311。自锁模块32包括安装在尿液入口311处的自锁开关321、以及设置在框架31内部的膨胀体322，通过膨胀体322吸收尿液膨胀将自锁开关321关闭达到自锁的目的。收集通道33竖直设置，直接开设在膨胀体322上，位于生物标志物反应模块的正上方，直接与生物标志物反应模块42连通，这种结构可为尿液提供毛细作用，使得收集通道33的吸水性大于膨胀体322的吸水性，使尿液渗透进入生物标志物反应模块42。为了进一步保证尿液的导流速度，在收集通道33中填充导流物质331，比如无纺布、吸墨纸等。为了避免发生生物标志物反应模块42还没润湿完全而发生自锁的情况，在所述膨胀体322的上表面没有开设收集通道33的区域覆盖一层薄膜，所述薄膜的吸水性小于所述膨胀体322的吸水性，该薄膜的材料可以是玻璃纸或聚甲基丙烯酸甲酯。The collection layer 3 includes a rectangular parallelepiped frame 31 made of transparent plastic, a self-locking module 32, and a collection channel 33 communicated with the biomarker reaction module 42; wherein the self-locking module 32, the collection channel 33, and the test layer 4 are all located in the frame. within 31. A urine inlet 311 is opened at the top center of the frame 31 . The self-locking module 32 includes a self-locking switch 321 installed at the urine inlet 311 and an expansion body 322 arranged inside the frame 31. The expansion body 322 absorbs urine expansion and closes the self-locking switch 321 to achieve the purpose of self-locking. The collection channel 33 is arranged vertically, directly opened on the expansion body 322, located directly above the biomarker reaction module, and directly communicated with the biomarker reaction module 42. This structure can provide capillary action for urine, so that the collection channel 33 The water absorption of the expansion body 322 is greater than that of the expansion body 322, so that the urine penetrates into the biomarker reaction module 42. In order to further ensure the diversion speed of the urine, the collecting channel 33 is filled with a diversion material 331 , such as non-woven fabric, blotting paper and the like. In order to avoid the self-locking situation that the biomarker reaction module 42 is not fully wetted, the area where the collection channel 33 is not provided on the upper surface of the expansion body 322 is covered with a layer of film, and the water absorption of the film is less than the required one. For the water absorption of the expansion body 322, the material of the film can be cellophane or polymethyl methacrylate.
所述测试层4包括测试层本体41、镶嵌在所述测试层本体41上的若干个生物标志物反应模块42，测试层本体41由疏水材料制成，位于框架31的最底层。框架31将测试层4包裹在其中，可对其进行保护，生物标志物反应模块42在与尿液中的生物标志物反应之后，所有的试剂块被锁在一个密闭的环境，这个密闭的环境可组织反应过后的试剂块与空气产生副反应，于此同时避免了颜色水合底物的蒸发。The test layer 4 includes a test layer body 41 and several biomarker reaction modules 42 embedded in the test layer body 41 . The test layer body 41 is made of hydrophobic material and is located at the bottom of the frame 31 . The frame 31 wraps the test layer 4 in it, which can protect it. After the biomarker reaction module 42 reacts with the biomarkers in the urine, all the reagent blocks are locked in a closed environment. This closed environment It can prevent the side reaction of the reacted reagent block with the air, and at the same time avoid the evaporation of the color hydration substrate.
所述智能检测软件包括用于采集标准色卡2与生物标志物反应模块42反应结果的图像采集模块，图像定位模块、图像透视转换模块、特征提取模块、数据处理模块、结果分析模块。The intelligent detection software includes an image acquisition module for collecting the reaction results of the standard color card 2 and the biomarker reaction module 42, an image positioning module, an image perspective conversion module, a feature extraction module, a data processing module, and a result analysis module.
如图8、图9所示，所述标准色卡2的四个角上设置有识别码21，用于图像定位模块对图像的定位。As shown in FIG. 8 and FIG. 9 , the four corners of the standard color card 2 are provided with identification codes 21 for positioning the image by the image positioning module.
所述图像透视转换模块通过采用尺度不变特征转换(scale-invariant featuretransform,sift)、SURF算法、BRISK算法或广义霍夫变换(generalized Hough transform)中的一种算法对图像进行透视转换。The image perspective transformation module performs perspective transformation on the image by using an algorithm among scale-invariant feature transform (scale-invariant feature transform, sift), SURF algorithm, BRISK algorithm or generalized Hough transform.
所述特征提取模块提取图像中生物标志物反应模块42和标准色卡2所对应的特征数据，其特征数据为RGB,sRGB,LMS,Von Kries LMS，XYZ中的一种。The feature extraction module extracts the feature data corresponding to the biomarker response module 42 and the standard color card 2 in the image, and the feature data is one of RGB, sRGB, LMS, Von Kries LMS, and XYZ.
所述数据处理模块是基于生物标志物反应模块42颜色与所对应的标准色卡2的相似度来实现生物标志物定性和半定量的判断，相似度最高的标准色卡2所对应的水平为尿液中该生物标志物的水平，图像相似度的比较采用线性判别(linear discriminantanalysis,LDA)、二次判别(quadratic discriminant analysis，QDA)或K均值聚类法(k-means clustering)中的一种。The data processing module realizes the qualitative and semi-quantitative judgment of biomarkers based on the similarity between the color of the biomarker response module 42 and the corresponding standard color card 2, and the level corresponding to the standard color card 2 with the highest similarity is The level of the biomarker in urine and the image similarity were compared using one of linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) or K-means clustering. kind.
使用时，本装置贴覆在尿不湿上使用，本发明还提供该装置的尿检方法，如图7所示，具体步骤如下：When in use, the device is pasted on the diaper for use, and the present invention also provides a urine testing method for the device, as shown in Figure 7, and the specific steps are as follows:
1)图像采集，将本装置从尿不湿中取出来，通过图像采集模块对标准色卡2与生物标志物反应模块42反应结果进行图像采集；1) Image acquisition, the device is taken out from the diaper, and image acquisition is performed on the reaction result of the standard color card 2 and the biomarker reaction module 42 through the image acquisition module;
2)图像定位与透视转换，图像定位模块利用识别码21进行定位识别，图像透视转换模块采用尺度不变特征转换(scale-invariant feature transform,sift)、SURF、BRISK或广义霍夫变换(generalized Hough transform)中的一中算法对图像进行透视转换；2) Image positioning and perspective transformation. The image positioning module uses the identification code 21 for positioning recognition. The image perspective transformation module uses scale-invariant feature transform (sift), SURF, BRISK or generalized Hough transform (generalized Hough transform). transform) performs perspective transformation on the image;
3)特征提取，采集图像中反应色块和标准色卡2所对应的特征数据，其特征数据可以是RGB,sRGB,LMS,Von Kries LMS或XYZ中的一种；3) feature extraction, collect the feature data corresponding to the reaction color block and the standard color card 2 in the image, and the feature data can be one of RGB, sRGB, LMS, Von Kries LMS or XYZ;
4)数据处理，生物标志物定性和半定量判断方法是基于生物标志物反应模块42颜色与所对应的标准色卡2的相似度，相似度最高的标准色块所对应的水平为尿液中该生物标志物的水平，图像相似度的比较采用线性判别(linear discriminant analysis,LDA)、二次判别(quadratic discriminant analysis，QDA)或K均值聚类法(k-meansclustering)种的一种；4) Data processing, biomarker qualitative and semi-quantitative judgment methods are based on the similarity between the color of the biomarker response module 42 and the corresponding standard color card 2, and the level corresponding to the standard color block with the highest similarity is the level in urine The level of the biomarker and the image similarity are compared using one of linear discriminant analysis (LDA), quadratic discriminant analysis (QDA) or K-means clustering (k-meansclustering);
5)结果分析。5) Analysis of results.
以上对本发明提供的一种可穿戴式智能尿检系统及尿检方法进行了详细介绍。具体实施例的说明只是用于帮助理解本发明的方法及其核心思想。应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以对本发明进行若干改进和修饰，这些改进和修饰也落入本发明权利要求的保护范围内。A wearable intelligent urine testing system and a urine testing method provided by the present invention have been introduced in detail above. The description of specific embodiments is only used to help understand the method and core idea of the present invention. It should be pointed out that for those skilled in the art, without departing from the principle of the present invention, some improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.
| Application Number | Priority Date | Filing Date | Title |
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| CN201810048332.5ACN108061732B (en) | 2018-01-18 | 2018-01-18 | Wearable intelligent urine detection system and urine detection method |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810048332.5ACN108061732B (en) | 2018-01-18 | 2018-01-18 | Wearable intelligent urine detection system and urine detection method |
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| CN108061732Atrue CN108061732A (en) | 2018-05-22 |
| CN108061732B CN108061732B (en) | 2023-06-30 |
| Application Number | Title | Priority Date | Filing Date |
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| CN201810048332.5AActiveCN108061732B (en) | 2018-01-18 | 2018-01-18 | Wearable intelligent urine detection system and urine detection method |
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