A kind of temperature sensitive active compacts peptide and preparation method thereofTechnical field
The present invention relates to a kind of skin care item, compact peptide and preparation method thereof more particularly, to a kind of temperature sensitive active.
Background technology
Skin aging refers to that skin function Aging damages, and protective capacities of the skin to body, regulating power etc. is declined,Thus skin does not adapt to the change of internal and external environment, the change of the appearance integral status such as color, color and luster, form, texture occurs.SkinThe aging of skin is divided into intrinsic aging and extrinsic aging.Intrinsic aging refers to the natural aging that skin increases with the age.TableIt is now whiteness of skin, fine wrinkles, flexibility decrease, cutis laxa etc. occurs.Extrinsic aging is main the reason is that solarization instituteThe light aging of cause.Show as wrinkle, cutis laxa, coarse, Beige color dermatodyschroia, telangiectasis, pigmentSpot formation etc..
The muscle and fascia that the Main Tissues of vagina elasticity and elasticity are basin bottom are maintained, vaginal delivery can different journeysThe damage pelvic floor tissue of degree, meanwhile, with advancing age, ovarian function is faded, and amount of estrogen is reduced, and props up fascia etc.Hold structure and retrogression occurs, muscle tone declines, and mucosal atrophy, makes vagina become more loose, lacks elasticity, long and longIt, there is urethra or Cystocele in some women, causes stress incontinence（Sneeze or can't help doing urine when jumping）, urinationDifficult or urinary infection repeatedly, or cause constipation because of Rectocele.
Part vaginal relaxation patient to the slow in reacting of stimulation or does not react in sexual life, is extremely difficult to orgasm, dayCause frigidity long, influence love life quality and even result in the alienation of mutual affection.Vaginal relaxation can cause vagina powerless " tightHold " penis, voluptus and orgasm lose, and frigidity, the moon are blown, and vaginal dryness, loose vagina is remained by pathogenic toxin, are triggeredVaginitis, cervicitis, or even uplink infect to endometritis, adnexitis etc. and are difficult to the gynecological disease cured.
Most products only have effects that firm skin in existing product, but cutis laxa aging, particularly femaleProperty cutis laxa can cause the appearance of many complication, so that substantial amounts of bacterium can be grown, and sunburn, microgroove, wrinkle on skinThe problems such as line, oily skin, acne, needs different skin care item to be maintained, and cost is larger and time-consuming and laborious.
The content of the invention
The technical problem to be solved in the present invention is overcome the defects of existing, there is provided a kind of temperature sensitive active compacts peptide and its preparationMethod, so as to solve the above problems.
To achieve the above object, the present invention provides following technical solution：A kind of temperature sensitive active compacts peptide, including below intoPoint：Deionized water, oriental cherry odor type, ASAP, poloxamer188, PLURONICS F87, propane diols, antibacterial peptide.
The temperature sensitive active peptide components percentage that compacts is：Deionized water 72.99%, oriental cherry odor type 0.01%,ASAP1%, poloxamer188 20%, PLURONICS F87 1%, propane diols 4%, antibacterial peptide 1%.
The temperature sensitive active compacts peptide pH value between 5-6.
The deionized water and oriental cherry odor type need carry out 72.99 before being configured:0.01 sample preparation is handled, light when havingDelicate fragrance produces, and confirms specific proportioning.
The poloxamer188 and PLURONICS F87 need carry out 20 before being configured:1 sample preparation is handled, then oneThe warm water of 50 degree of cup, canned pipe is put into warm water, to test whether that moment solidifies.
A kind of temperature sensitive active compacts peptide and preparation method thereof, comprises the following steps：
Step 1: preparing a certain amount of deionized water as base stock, a small amount of oriental cherry odor type is added afterwards, 5 points are stirred to itClock, adds a certain amount of ASAP after stirring, carry out dispensing while quickly being stirred, it is merged rapidly.
Step 2: soak 8 after the solution prepared and a certain amount of poloxamer188 and PLURONICS F87 are mixedHour is as spare.
Step 3: antibacterial peptide is placed on to 50 degree of warm water dissolves transparent and then dispensing propane diols, stir evenly, by itPour into the poloxamer188 and PLURONICS F87 bubbled open completely stir can carry out after five minutes it is filling.
Compared with prior art, the beneficial effects of the invention are as follows：This kind of temperature sensitive active compacts peptide and preparation method thereof, not onlyHigh effect nontoxic, and in use harmful effect will not be produced to human body and article, and inside can be effectively containing ASAPImprove the skin problems such as skin below aging, sunburn, microgroove, wrinkle, oily skin, acne.ASAP or a kind of natural organicAntiseptic, to bacterium can kill so as to reduce infringement of the bacterium to skin, while temperature sensitive active compacts in peptide containing anti-Bacterium peptide, antibacterial peptide have broad spectrum antibiotic activity, can quickly killing target, and be wherein much pure natural peptide, make it fastShort-term training can be to gramnegative bacterium, gram-positive bacterium, fungi, parasite, tumour cell for potential medicineGuarantee health is quickly killed Deng harmful bacteria virus etc., and immunity, accelerating wound healing process can be improved, to human body skinSkin has higher benefit, by the oriental cherry odor type that contains of inside, can remove temperature sensitive active and compact a small amount of peculiar smell in peptide, makeIt smells that A sweety scent assails the nostrils, improves use feeling, simple in structure, the easy to operate maintenance for skin plays very big sideHelp.
Embodiment
Technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is onlyIt is part of the embodiment of the present invention, instead of all the embodiments, based on the embodiments of the present invention, ordinary skill peopleMember's all other embodiments obtained without making creative work, belong to the scope of protection of the invention.
The present invention provides a kind of technical solution：A kind of temperature sensitive active compacts peptide, including following component：Deionized water, oriental cherryOdor type, ASAP, poloxamer188, PLURONICS F87, propane diols, antibacterial peptide.
The temperature sensitive active peptide components percentage that compacts is：Deionized water 72.99%, oriental cherry odor type 0.01%, ASAP1%, poolLuo Shamu 40720%, PLURONICS F87 1%, propane diols 4%, antibacterial peptide 1%.
Temperature sensitive active compacts peptide pH value between 5-6.
Deionized water and oriental cherry odor type need carry out 72.99 before being configured:0.01 sample preparation is handled, when there is light delicate fragranceGeneration, confirms specific proportioning.
Poloxamer188 and PLURONICS F87 need carry out 20 before being configured:1 sample preparation is handled, and is then filling a cup of 50The warm water of degree, canned pipe is put into warm water, to test whether that moment solidifies.
A kind of temperature sensitive active compacts peptide and preparation method thereof, comprises the following steps：
Step 1: preparing a certain amount of deionized water as base stock, a small amount of oriental cherry odor type is added afterwards, 5 points are stirred to itClock, adds a certain amount of ASAP after stirring, carry out dispensing while quickly being stirred, it is merged rapidly.
Step 2: soak 8 after the solution prepared and a certain amount of poloxamer188 and PLURONICS F87 are mixedHour is as spare.
Step 3: antibacterial peptide is placed on to 50 degree of warm water dissolves transparent and then dispensing propane diols, stir evenly, by itPour into the poloxamer188 and PLURONICS F87 bubbled open completely stir can carry out after five minutes it is filling.
Embodiment 1：Prepare the deionized water of 5000g as base stock, the rear oriental cherry odor type for adding 1g, 5 are stirred to itMinute, 5gASAP is added after stirring, dispensing is carried out while quickly being stirred, it is merged rapidly, will make4 hours are soaked as spare after solution and a certain amount of poloxamer188 and the PLURONICS F87 mixing got ready, by antibacterialThe warm water that peptide is placed on 60 degree dissolves transparent and then launches propane diols, stirs evenly, is poured into the poloxamer bubbled open completely407 and PLURONICS F87 in stir can carry out after five minutes it is filling.
Embodiment 2：Prepare the deionized water of 6000g as base stock, the rear oriental cherry odor type for adding 1g, 10 are stirred to itMinute, 4gASAP is added after stirring, dispensing is carried out while quickly being stirred, it is merged rapidly, will make6 hours are soaked as spare after solution and a certain amount of poloxamer188 and the PLURONICS F87 mixing got ready, by antibacterialThe warm water that peptide is placed on 70 degree dissolves transparent and then launches propane diols, stirs evenly, is poured into the poloxamer bubbled open completely407 and PLURONICS F87 in stir can carry out after five minutes it is filling.
Embodiment 3：Prepare the deionized water of 7000g as base stock, the rear oriental cherry odor type for adding 1g, 10 are stirred to itMinute, 3gASAP is added after stirring, dispensing is carried out while quickly being stirred, it is merged rapidly, will make8 hours are soaked as spare after solution and a certain amount of poloxamer188 and the PLURONICS F87 mixing got ready, by antibacterialThe warm water that peptide is placed on 80 degree dissolves transparent and then launches propane diols, stirs evenly, is poured into the poloxamer bubbled open completely407 and PLURONICS F87 in stir can carry out after five minutes it is filling.
Embodiment 4：Prepare the deionized water of 7500g as base stock, the rear oriental cherry odor type for adding 1g, 10 are stirred to itMinute, 2gASAP is added after stirring, dispensing is carried out while quickly being stirred, it is merged rapidly, will make10 hours are soaked as spare after solution and a certain amount of poloxamer188 and the PLURONICS F87 mixing got ready, by antibacterialThe warm water that peptide is placed on 90 degree dissolves transparent and then launches propane diols, stirs evenly, is poured into the poloxamer bubbled open completely407 and PLURONICS F87 in stir can carry out after five minutes it is filling.
Embodiment 4：Prepare the deionized water of 7700g as base stock, the rear oriental cherry odor type for adding 1g, 5 are stirred to itMinute, 1gASAP is added after stirring, dispensing is carried out while quickly being stirred, it is merged rapidly, will make12 hours are soaked as spare after solution and a certain amount of poloxamer188 and the PLURONICS F87 mixing got ready, by antibacterialThe warm water that peptide is placed on 50 degree dissolves transparent and then launches propane diols, stirs evenly, is poured into the poloxamer bubbled open completely407 and PLURONICS F87 in stir can carry out after five minutes it is filling.
Embodiment 5：Prepare the deionized water of 8000g as base stock, the rear oriental cherry odor type for adding 1g, 5 are stirred to itMinute, 1gASAP is added after stirring, dispensing is carried out while quickly being stirred, it is merged rapidly, will make8 hours are soaked as spare after solution and a certain amount of poloxamer188 and the PLURONICS F87 mixing got ready, by antibacterialThe warm water that peptide is placed on 40 degree dissolves transparent and then launches propane diols, stirs evenly, is poured into the poloxamer bubbled open completely407 and PLURONICS F87 in stir can carry out after five minutes it is filling.
This kind of temperature sensitive active compacts peptide and preparation method thereof, not only high effect nontoxic, but also in use will not be to peopleBody and article produce harmful effect, and the internal ASAP that contains can effectively improve skin below aging, sunburn, microgroove, wrinkle, oilThe skin problems such as property skin quality, acne.ASAP or a kind of natural organic antibacterial agent, to bacterium can kill thin so as to reduceInfringement of the bacterium to skin, while temperature sensitive active compacts and contains antibacterial peptide in peptide, antibacterial peptide has broad spectrum antibiotic activity, can be quickKilling target, and be wherein much pure natural peptide, it is rapidly become potential medicine to Gram-negativeHarmful bacteria virus such as bacterium, gram-positive bacterium, fungi, parasite, tumour cell etc. quickly kills guarantee health,And immunity, accelerating wound healing process can be improved, there is higher benefit to human skin, the oriental cherry contained by inside is fragrantType, can remove temperature sensitive active and compact a small amount of peculiar smell in peptide, smelling it, A sweety scent assails the nostrils, improves use feeling, structureSimply, the easy to operate maintenance for skin plays very big help.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention,Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be usedTo modify to the technical solution described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic,Within the spirit and principles of the invention, any modification, equivalent replacement, improvement and so on, should be included in the present invention'sWithin protection domain.