A kind of medical high-strength degree eptfe membrane flake products and preparation method thereofTechnical field
The present invention relates to field of medical materials, and in particular to a kind of medical high-strength degree eptfe membrane flake products andIts preparation method.
Background technology
Expanded PTFE (expanded polytetrafluoroethylene, e-PTFE) is in the industry cycle commonly called as " swollenBody ".It is characterized in that " stretching " process, produces substantial amounts of " section and fiber " structure, forms micropore, exactly because these are specialMicrocellular structure, impart the special property of expanded PTFE material:It is good biocompatibility, stability, hydrophobicity, softToughness etc..Come out so far since the sixties in last century, be widely used in the fields such as industry, military affairs, medical treatment.But meshThere is certain deficiency in the preceding expanded PTFE material clinically used, i.e.,：
(1) using being directly thermally bonded, the peel strength deficiency of product, the risk of layering be present；
(2) it is that tensile strength has directionality that expanded PTFE material, which has the problem of maximum, in fiber orientationIntensity is far longer than the intensity in its vertical direction.If applied in medical surgery field, material needs certain support in itselfIntensity and certain anti-suture tension.
The content of the invention
It is an object of the invention to provide a kind of medical high-strength degree eptfe membrane flake products and preparation method thereof, withSolve the problems, such as that its tensile strength of expanded PTFE sheet material is insufficient, anti-suture tension has directionality.
To reach above-mentioned purpose, the invention provides a kind of preparation of medical high-strength degree eptfe membrane flake productsMethod, it comprises the following steps：Step 1：Prepare eptfe layer；Step 2：The varicosity that two layers of step 1 obtains is gatheredTetrafluoroethene layer is placed according to respective fiber orientation in 90 ° of angle dislocation stackings, and places adhesive layer between the two layers；StepRapid 3：Layered product obtained by step 2 is fixed and press perpendicular in the stacking direction, heats afterwards and be incubated a period of time,Obtain eptfe membrane flake products.
The preparation method of above-mentioned medical high-strength degree eptfe membrane flake products, wherein, in step 3, verticallyAfter pressurization, it is heated to 300-380 DEG C and is incubated 8-12 minutes.
The preparation method of above-mentioned medical high-strength degree eptfe membrane flake products, wherein, the step 1 include withLower step：Step 1.1：At less than 19 DEG C, polyflon and extrusion aid are pressed 6:1-2:1 weight is quiet than mixingPut overnight；Step 1.2：Temperature is raised to 25 DEG C -35 DEG C, it is bar-shaped to be pre-formed as base；Step 1.3：At 45 DEG C -60 DEG C, carry outPush, form the first sheet material；Step 1.4：The first sheet material obtained by step 1.3 is subjected to roll-in, forms the second sheet material；Step1.5：Temperature is raised to 80-120 DEG C, the second sheet material obtained by step 1.4 is dried, so that extrusion aid volatilizees；Step1.6：Dried second sheet material is fixed on one-way stretcher, is warming up to 280-350 DEG C, carries out simple tension and maintenance oneThe section time, obtain eptfe layer.
The preparation method of above-mentioned medical high-strength degree eptfe membrane flake products, wherein, push the first of formationThe thickness of sheet material is 0.8-1.5mm；The thickness for the second sheet material that roll-in is formed is 0.3-0.4mm.
The preparation method of above-mentioned medical high-strength degree eptfe membrane flake products, wherein, in step 1.6, instituteThe multiple of stretching is stated as 5-8 times and maintains 8-10 minutes.
It is described present invention also offers medical high-strength degree eptfe membrane flake products prepared by a kind of above methodEptfe membrane flake products are three-decker, are followed successively by from top to bottom：First eptfe layer, adhesive layerWith the second eptfe layer；The fiber of first eptfe layer and the second eptfe layer is walkedTo angle be in 90 °.
Above-mentioned medical high-strength degree eptfe membrane flake products, wherein, first eptfe layerThickness with the second eptfe layer is 0.24-0.32mm.
Above-mentioned medical high-strength degree eptfe membrane flake products, wherein, the eptfe membrane piece productionThe thickness of product is 0.5-0.6mm.
Above-mentioned medical high-strength degree eptfe membrane flake products, wherein, the material of the adhesive layer is moulded for fluorineMaterial.
Above-mentioned medical high-strength degree eptfe membrane flake products, wherein, the fluoroplastics are polytetrafluoroethylene (PTFE).
Had the advantages that relative to prior art：
(1) after being directed to expanded PTFE drawn, there is direction otherness in its tensile strength.The present invention takes dislocationThe mode of stacking, it is in 90 ° of angles using fiber orientation, reduces or eliminates difference, meet the requirement sutured in surgical operation.
(2) it is small for polytetrafluoroethylene (PTFE) material self friction power, the characteristics of being not easy to bond.The present invention is bonded by introducingAgent so that the bonding force between eptfe layer and layer is stronger, overcomes the problem of existing varicosity is layered, togetherWhen, the introducing of adhesive enhances tensile strength.
(3) adhesive used in is fluoroplastics；Preferentially using polytetrafluoroethylene (PTFE) (Poly tetra fluoroethylene,PTFE) film, products obtained therefrom only contain polytetrafluoroethylene (PTFE) composition.
(4) adhesive phase is physical layer, in terms of control histocyte " infinitely growing into ", iris action is played, to preventSecond operation is needed when necessary, is easily peeled off and takes out.
Brief description of the drawings
Fig. 1 is the structural representation of medical high-strength degree eptfe membrane flake products of the present invention.
Embodiment
Below in conjunction with accompanying drawing, by specific embodiment, the invention will be further described, and these embodiments are merely to illustrateThe present invention, it is not limiting the scope of the invention.
The invention provides a kind of preparation method of medical high-strength degree eptfe membrane flake products, it includes followingStep：Step 1：Prepare eptfe layer；Step 2：The eptfe layer that two layers of step 1 is obtained is according to eachFrom fiber orientation placed in the dislocation stacking of 90 ° of angles, and place adhesive layer between the two layers and (preferably, select polytetrafluoroVinyl film)；Step 3：Layered product obtained by step 2 is fixed, it is ensured that smooth after placement, non-wrinkled and bubble, and edgeStacked direction press perpendicular, heat afterwards and be incubated a period of time, obtain eptfe membrane flake products.
Preferably, in step 3, after press perpendicular, it is heated to 300-380 DEG C and is incubated 8-12 minutes.
Specifically, the step 1 comprises the following steps：Step 1.1：At less than 19 DEG C, by polyflon withExtrusion aid presses 6:1-2:1 weight is stood overnight than mixing, it is ensured that extrusion aid is fully penetrated into inside raw material；Step 1.2：RiseIt is bar-shaped to be pre-formed as base to 25 DEG C -35 DEG C for high-temperature；Step 1.3：At 45 DEG C -60 DEG C, pushed, form the first sheet material；Step 1.4：The first sheet material obtained by step 1.3 is subjected to roll-in, forms the second sheet material；Step 1.5：Temperature is raised to 80-120 DEG C, the second sheet material obtained by step 1.4 is dried, so that extrusion aid volatilizees；Step 1.6：By dried secondSheet material is fixed on one-way stretcher, is warming up to 280-350 DEG C, is carried out simple tension and is maintained a period of time, obtains varicosity and gatherTetrafluoroethene layer.
Preferably, the thickness for pushing the first sheet material of formation is 0.8-1.5mm；The thickness of the second sheet material that roll-in is formed is0.3-0.4mm。
Preferably, in step 1.6, the multiple of the stretching is 5-8 times and maintains 8-10 minutes.
As shown in figure 1, present invention also offers medical high-strength degree eptfe membrane prepared by a kind of above methodFlake products, the eptfe membrane flake products are three-decker, are followed successively by from top to bottom：First expanded PTFELayer 1, the eptfe layer 3 of adhesive layer 2 and second；The varicosity poly- four of first eptfe layer 1 and secondThe angle of the fiber orientation of PVF layer 3 is in 90 ° (direction of arrow is fiber orientation in Fig. 1).
Preferably, the thickness of the eptfe layer 3 of the first eptfe layer 1 and second is 0.24-0.32mm。
Preferably, the thickness of the eptfe membrane flake products is 0.5-0.6mm.
Preferably, the material of the adhesive layer 2 is fluoroplastics.
It is highly preferred that the fluoroplastics are polytetrafluoroethylene (PTFE).
In summary, the present invention uses simple tension, dislocation stacking, and uses binding agent, passes through sintering, sizing, gainedEptfe membrane flake products have high intensity, while eliminate each to otherness.Intermediary adhesive layer is physical layer, canInfinitely grown into, realized " limited to grow into " with obstructing histocyte, good clear interface is provided for second operation, it is convenient using bluntProperty peel off, take out.Eptfe membrane flake products provided by the present invention are used mainly for department of general surgery, such as hernia repair,Itself is very thin, and thickness is 0.5-0.6mm or so, it is possible to reduce the foreign body sensation of postoperative patient.
Although present disclosure is discussed in detail by above preferred embodiment, but it should be appreciated that above-mentionedDescription is not considered as limitation of the present invention.After those skilled in the art have read the above, for the present invention'sA variety of modifications and substitutions all will be apparent.Therefore, protection scope of the present invention should be limited to the appended claims.