A kind of recyclable cardiac stentTechnical field
The present invention relates to technical field of medical instruments, and in particular to a kind of recyclable cardiac stent.
Background technology
Cardiac stent is also known as coronary stent, and being that a kind of needs are long-term intervenes in heart and with meeting heartbeatThe conventional high-value consumables medical instruments of physiology mechanical function, there is dredging arteries, improve myocardial blood supply caused by coronary heart diseaseThe effect of deficiency, heart arter obstruction, stable disease for openheart surgery and in the future have vital purpose.
Cardiac stent experienced the Course of development of metallic support, film coating bracket, Soluble Stent at present, at present third generation branchThe development of frame is not yet ripe, and occuping market leading position is still second generation film coating bracket.Main material is stainless steel, NiTiAlloy or cochrome.
For heart infarction patient, implantation support is the treatment means got instant result.But current cardiac stent still suffer fromLower defect：Due to coronary artery bracket and it is not required to fill a lifetime in body, but has ' military service ' cycle, in intervention coronary artery 6After individual month, mission has just been completed, ' can have been retired from political life after winning tremendous successes ', has allowed blood vessel to recover original looks.Metallic support can not due to materialRecovery, even if completing task, also will with heart together all one's life, can stimulate on the contrary sometimes blood vessel produce inflammatory reaction, or even productionRaw thrombus in stents and threat to life.
The content of the invention
(1) technical problems to be solved
It is not recyclable to solve existing cardiac stent it is an object of the invention to provide a kind of recyclable cardiac stent, and meetingThe problem of stimulating blood vessel to produce inflammatory reaction.
(2) technical scheme
In order to solve the above-mentioned technical problem, the present invention provides a kind of recyclable cardiac stent, including rack body and heatingDevice, the rack body are made up of liquid metal solidification, and the surface of the rack body is coated with medicine film, the heating dressPut for heating the rack body.
Wherein, the rack body is network structure, tubular structure or cyclic structure.
Wherein, the fusing point of the liquid metal is 40.5 DEG C~41.5 DEG C.
Wherein, the liquid metal is the one or more in bismuth, indium, tin, gallium alloy.
Wherein, the medicine film includes anti-proliferative drugs.
Wherein, the anti-proliferative drugs are rapamycin or everolimus.
Wherein, the medicine film also includes nutrient and antibiotic.
Wherein, the antibiotic is quadracycline and/or single-phase type alpha tricalcium phosphate.
Wherein, the heater is induction heating apparatus, microwave heating equipment, laser heating device or resistance heating dressPut.
(3) beneficial effect
Compared with prior art, the invention has the advantages that：
1) conversion of liquid metal solid liquid phase is flexible, and curing rate is fast, and stable mechanical property after solidification；If there is taking-up demandWhen, position where rack body is heated by family's thermal, makes liquid metal by Solid State Transformation be liquid, and by leadingPipe suctions out completely in blood vessel, realizes recovery.In addition, liquid metal possesses good biocompatibility, antithrombotic is corrosion-resistant,To vascular wall not damaged, avoiding stimulates blood vessel to produce inflammatory reaction.
2) medicine film is coated on the surface of rack body, eliminating rack body stimulates the misgivings of local organization as foreign matter, protectsDemonstrate,prove rack body and the normal growth of arterial contact position surrounding tissue.
3) liquid metal has good X-ray image in vivo, it is not necessary to is additionally adding other contrast agent, you can profitMonitored with X-ray machine, be easy to that at tracking rack body position, radiography observation can be accurately positioned, reduce cardiac stentThe difficulty of operation.
4) recyclable cardiac stent provided by the invention, its is simple in construction, is advantageous to reduce cost；Simple production process,Can high-speed and continuous production, and random length can be cut into as needed.
Brief description of the drawings
Fig. 1 is a kind of structural representation of recyclable cardiac stent in the embodiment of the present invention 1；
Fig. 2 is a kind of schematic cross-section of recyclable cardiac stent in Fig. 1；
Fig. 3 is a kind of structural representation of recyclable cardiac stent in the embodiment of the present invention 2；
Fig. 4 is a kind of schematic cross-section of recyclable cardiac stent in Fig. 3；
Description of reference numerals
1- medicine films；2- rack bodies.
Embodiment
With reference to the accompanying drawings and examples, the embodiment of the present invention is described in further detail.Following instanceFor illustrating the present invention, but it is not limited to the scope of the present invention.
In the description of the invention, it is necessary to explanation, unless otherwise indicated, " multiple " be meant that two or two withOn；The orientation of the instruction such as term " on ", " under ", "left", "right", " interior ", " outer ", " front end ", " rear end ", " head ", " afterbody "Or position relationship is based on orientation shown in the drawings or position relationship, is for only for ease of the description present invention and simplifies description, andIt is not instruction or implies signified device or element there must be specific orientation, with specific azimuth configuration and operation, thereforeIt is not considered as limiting the invention.In addition, term " first ", " second ", " the 3rd " etc. are only used for describing purpose, and can notIt is interpreted as indicating or implying relative importance.
In the description of the invention, it is necessary to illustrate, unless otherwise clearly defined and limited, term " installation ", " phaseEven ", " connection " should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected, or be integrally connected；CanTo be mechanical connection or electrical connection；Can be joined directly together, can also be indirectly connected by intermediary, Ke YishiThe connection of two element internals.For the ordinary skill in the art, with concrete condition above-mentioned term can be understood at thisConcrete meaning in invention.
Embodiment 1：
As shown in Figure 1, 2, a kind of recyclable cardiac stent provided for the present embodiment, including rack body and heating fillPut.Rack body is made up of liquid metal solidification, and the surface of rack body is coated with medicine film, and heater is used for heated holderMain body.
Below by specific process, further detailed description.
The rack body 2 of medicine film 1 intervenes operation by cardiac stent and reaches blood vessel blockage position in coating；Work as operative failureOr when having the demand for taking out rack body 2, the place position of rack body 2 can be heated by heater；ReachAfter liquid metal fusing point, rack body 2 is liquid by Solid State Transformation, suctions out in blood vessel liquid metal using conduit, realizesRecovery.
Wherein, heater is induction heating apparatus, microwave heating equipment, laser heating device, resistive heating device etc..In the present embodiment, heater is electromagnetic induction heater.
Further, liquid metal is low-melting-point metal or its alloy, by bismuth, indium, tin, gallium alloy it is one or more of notMatch and form with content, its fusing point is 40.5 DEG C~41.5 DEG C.
Further, medicine film 1 includes anti-proliferative drugs.Wherein, anti-proliferative drugs be rapamycin, everolimus,Myolimus etc., eliminating rack body 2 stimulates the misgivings of local organization as foreign matter, ensures rack body 2 and arterial contact portionThe normal growth of position surrounding tissue.
Further, medicine film 1 also includes nutrient and antibiotic.Wherein, nutrient includes calcium, magnesium, phosphorus, ferro element,Exist with atom or with compound form；Antibiotic is quadracycline (TTCH) and single-phase type alpha tricalcium phosphate (α-TCP), is subtractedLess or avoid causing microorganism infection in surgical procedure.
Further, rack body 2 is network structure, tubular structure or cyclic structure.In the present embodiment, rack body 2For the diamond-mesh structure of interconnection.
The present embodiment provides a kind of recyclable cardiac stent, and its is simple in construction, is advantageous to reduce cost；Production technology letterIt is single, can high-speed and continuous production, and random length can be cut into as needed.The conversion of liquid metal solid liquid phase is flexible, and solidifies speedDegree is fast, recoverable；If have taking-up demand, position where rack body can be heated by local heating, madeLiquid metal is liquid by Solid State Transformation, and suctioned out completely in blood vessel by conduit, realizes recovery.In addition, liquid metal is gathered aroundThere is good biocompatibility, antithrombotic is corrosion-resistant, and to vascular wall not damaged, avoiding stimulates blood vessel to produce inflammatory reaction.TogetherWhen, liquid metal has good X-ray image in vivo, it is not necessary to is additionally adding other contrast agent, you can utilize X-ray machineMonitored, be easy to that at tracking rack body position, radiography observation can be accurately positioned, reduce the difficulty of cardiac stent operationDegree.
Embodiment 2：
The present embodiment is substantially the same manner as Example 1, brief for description, during the description of the present embodiment, no longerTechnical characteristic same as Example 1 is described, only illustrates the present embodiment difference from Example 1：
As shown in Figure 3,4, a kind of recyclable cardiac stent that the present embodiment provides, rack body 2 are positive six side of interconnectionShape network structure.
The present embodiment provides a kind of recyclable cardiac stent, and rack body makes support for the regular hexagon network structure of interconnectionMain body contacts the stress fully, increased between the two with blood vessel, and crystallized ability is strong, it is not easy to displacement, high mechanical strength, fitsUnifying a little stress can be with the larger position of load.
Biocompatibility refers to material and causes appropriate reaction in the privileged site of body.According to International Organization for standardizationThe explanation of (International Standards Organization, ISO) meeting, biocompatibility refer to life entity tissueA kind of performance aitiogenic to non-active material, generally refers to the compatibility between material and host.Biomaterial is implanted into peopleAfter body, to specific biological tissue's environmental effects and effect, biological tissue also can have an impact and act on to biomaterial,Both ringings are continued for, and are removed until reaching balance or implant.Biocompatibility is biomaterial researchIn the theme that runs through all the time.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present inventionGod any modification, equivalent substitution and improvements made etc., should be included in the scope of the protection with principle.