技术领域technical field
本发明涉及一种向胃肠道提供药物的系统。The present invention relates to a system for delivering drugs to the gastrointestinal tract.
背景技术Background technique
对于肠道的不同部位，其手术可及性大为不同。例如，对人类小肠功能紊 乱进行诊断以及治疗的过程就十分困难，这是由小肠的长度(一般情况下长约 21英尺或者7米)以及小肠的难以触及性决定的。同样地，结肠的某些部位也 难以接近并进行治疗。因此，很有必要提供一种采用小创面或者微创技术的设 备来用于肠道难以触及部位(例如小肠以及结肠)的诊断或治疗。Surgical accessibility varies widely for different parts of the bowel. For example, the process of diagnosing and treating disorders of the human small bowel is difficult due to its length (typically about 21 feet or 7 meters) and its inaccessibility. Likewise, certain parts of the colon are difficult to access and treat. Therefore, it is necessary to provide a device that uses a small wound or a minimally invasive technique for diagnosis or treatment of difficult-to-reach parts of the intestinal tract (such as the small intestine and colon).
可吞咽遥测胶囊已被用于多种治疗与诊断的实际应用中。某些应用研究已 经提出利用可吞咽胶囊向肠道的特定部位给送治疗药物，胶囊可根据所接收到 的外部射频信号来实现精确的药物释放。射频信号能够启动位于胶囊内部的机 电设备，进而释放药剂。相似地，某些应用研究还提出利用胶囊从肠道中获取 样本，可通过远程遥控启动胶囊内的机电取样设备以完成整个取样过程，之后 胶囊将通过人体排泄得以回收。还有一些应用研究提出将胶囊用于获取肠道的 内部图像或者视频信息，或者测量肠道的pH值、压力或者温度。还有一种装 备有电极的自动胶囊已被提出用于在经过胃肠道时提供电刺激，以刺激恢复胃 肠道的有效蠕动功能。此类设备系统能够推进吞入式胶囊通过肠道并抵达目的 区域。Swallowable telemetry capsules have been used in a variety of therapeutic and diagnostic applications. Some applied research has proposed the use of swallowable capsules to deliver therapeutic drugs to specific parts of the intestinal tract, and the capsules can achieve precise drug release according to the received external radio frequency signals. The radio frequency signal activates an electromechanical device located inside the capsule, which releases the drug. Similarly, some applied research also proposes to use capsules to obtain samples from the intestinal tract, and the electromechanical sampling equipment inside the capsules can be remotely activated to complete the entire sampling process, after which the capsules will be recovered through human excretion. There are also some applied studies that propose using the capsules to obtain internal images or video information of the intestinal tract, or to measure the pH, pressure or temperature of the intestinal tract. Also, an automated capsule equipped with electrodes has been proposed to provide electrical stimulation while passing through the GI tract to stimulate the recovery of effective peristaltic function of the GI tract. These device systems are capable of advancing swallowable capsules through the intestinal tract and to the area of interest.
目前医疗领域使用的胶囊内窥镜不可避免的存在患者体内滞留和所得图 片无位置信息等问题，对疾病的诊断主要依靠医生的临床经验，因此具有定位 功能的胶囊内窥镜被提上日程。目前国际上主要有以下几种定位方式：RF射 频信号定位、内置永磁元件的磁场定位、声音定位、RF射频信号+CT定位或 者MRI定位，更甚者采用辐射源定位。上述的几种定位方式，要么需要采用 昂贵、笨重的辅助设备，如RF射频信号定位和内置永磁元件的磁场定位需要 穿戴式医疗辅助设备完成定位；要么对人体产生或多或少的危害，如内置永磁元件的磁场定位和辐射源定位。Capsule endoscopes currently used in the medical field inevitably have problems such as patient retention in the body and no location information in the obtained images. The diagnosis of diseases mainly depends on the clinical experience of doctors. Therefore, capsule endoscopes with positioning functions are put on the agenda. At present, there are mainly the following positioning methods in the world: RF radio frequency signal positioning, magnetic field positioning with built-in permanent magnet components, sound positioning, RF radio frequency signal + CT positioning or MRI positioning, and even radiation source positioning. The above positioning methods either require expensive and cumbersome auxiliary equipment, such as RF radio frequency signal positioning and magnetic field positioning with built-in permanent magnet components, which require wearable medical auxiliary equipment to complete positioning; or cause more or less harm to the human body, Such as magnetic field positioning and radiation source positioning of built-in permanent magnet components.
发明内容Contents of the invention
本发明为了解决现有技术中存在的问题，设计了一种向胃肠道提供药物的 系统。In order to solve the problems in the prior art, the present invention designs a system for supplying medicine to the gastrointestinal tract.
为实现上述目的，本发明采用的技术方案为：To achieve the above object, the technical solution adopted in the present invention is:
一种向胃肠道提供药物的系统，该系统包括：A system for delivering a drug to the gastrointestinal tract comprising:
一个尺寸可以穿过病人胃肠道的胶囊；a capsule sized to pass through the patient's gastrointestinal tract;
一个与胶囊相连的发射器，该发射器可以在胶囊和病人体外的一个位置 之间发送追踪信号，从而追踪胶囊在病人肠道内的线性位置；a transmitter attached to the capsule that transmits a tracking signal between the capsule and a location outside the patient's body, thereby tracking the linear position of the capsule within the patient's intestinal tract;
一个参考信号发生器，该发生器与胶囊相连，该参考信号发生器可用来生 成和传送参考引号，用来识别追踪信号组织的时间；A reference signal generator, which is connected to the capsule, which can be used to generate and transmit reference marks to identify the time of tracing signal tissue;
一个药物运送装置，用来将药物运送到肠道中；以及a drug delivery device to deliver the drug into the intestine; and
一个控制器，用来在胶囊穿过肠道的时候，根据胶囊在肠道中的位置，向 所需的位置提供药物。A controller to deliver the drug to the desired location as the capsule travels through the intestine, based on where the capsule is in the intestine.
作为本发明所述的向胃肠道提供药物的系统的一种优选方案，所述的药物 运送装置包括一个阀门或一个电磁阀。As a preferred solution of the system for supplying drugs to the gastrointestinal tract of the present invention, the drug delivery device includes a valve or an electromagnetic valve.
作为本发明所述的向胃肠道提供药物的系统的一种优选方案，所述的药物 运送装置包括一个RF接收器，可接收外部信号，RF接收器可与控制器或药物 运送装置相连。As a preferred solution of the system for supplying drugs to the gastrointestinal tract of the present invention, the drug delivery device includes an RF receiver capable of receiving external signals, and the RF receiver can be connected with the controller or the drug delivery device.
作为本发明所述的向胃肠道提供药物的系统的一种优选方案，还包括一个 传感器，用来感应肠道的状况，该传感器可以与控制器或药物运送装置相连， 传感器包括一个压力传感器、一个应变仪。As a preferred solution of the system for supplying drugs to the gastrointestinal tract according to the present invention, it also includes a sensor for sensing the condition of the intestinal tract, the sensor can be connected with the controller or the drug delivery device, and the sensor includes a pressure sensor , a strain gauge.
附图说明Description of drawings
图1是本发明用在某用户身上的追踪系统。Fig. 1 is the tracking system used by the present invention on a certain user.
图2是图1所述追踪系统的部分截面视图。FIG. 2 is a partial cross-sectional view of the tracking system of FIG. 1 .
图3是所述的胶囊的部分截面视图。Figure 3 is a partial sectional view of the capsule.
图4是图3所述胶囊部分结构放大示意图。Fig. 4 is an enlarged schematic diagram of a partial structure of the capsule described in Fig. 3 .
图5是图1所述胶囊的电子电路图。Fig. 5 is an electronic circuit diagram of the capsule of Fig. 1 .
其中:100、电线导管 100a、100b、电线 101、102、103、104、诊断 帖 105、外部记录器 106、壳体 106a、接口壁 107a、声换能器 107m、衬垫材料 108a、射频线圈 109、粘结层110、胶囊 111、胶 囊主体 111a、不透射线标志物 131、后端 131a、后端内端面 132、 前端132a、前端内端面 135、射频线圈 136a、136b、136c、声换能器 137、压电晶体 138、电极板139、衬垫材料Wherein: 100, wire conduit 100a, 100b, wire 101, 102, 103, 104, diagnostic post 105, external recorder 106, housing 106a, interface wall 107a, acoustic transducer 107m, gasket material 108a, radio frequency coil 109 , adhesive layer 110, capsule 111, capsule main body 111a, radiopaque marker 131, rear end 131a, rear end inner end surface 132, front end 132a, front end inner end surface 135, radio frequency coil 136a, 136b, 136c, sound transducer 137, piezoelectric crystal 138, electrode plate 139, liner material
具体实施方式detailed description
下面结合附图和具体实施方式对本发明作进一步详细说明。The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.
实施例1Example 1
在图1中，展示了安装在病人深山的本发明的追踪系统160。追踪系统160 包含一个外部记录器105；四个诊断贴101、102、103和104，这些诊断仪含 有声音及EM发射器/接收器；以及一个胶囊110，该胶囊能够被患者吞服，或 是能够在肠道内进行运动。外部记录器105固定在患者腹部之外。诊断贴101、 102、103和104粘贴在病人皮肤上，并且具有声音传送/耦合材料，如凝胶层， 位于病人皮肤和诊断贴101、102、103和104之间。In FIG. 1 , the tracking system 160 of the present invention installed in a remote mountain of a patient is shown. Tracking system 160 includes an external recorder 105; four diagnostic patches 101, 102, 103, and 104, which contain sound and EM transmitters/receivers; and a capsule 110, which can be swallowed by the patient, or Ability to move through the intestines. External recorder 105 is fixed outside the patient's abdomen. The diagnostic patches 101 , 102 , 103 and 104 are attached to the patient's skin and have a sound transmitting/coupling material, such as a gel layer, between the patient's skin and the diagnostic patches 101 , 102 , 103 and 104 .
如图2所示，诊断贴101包括一个塑料外壳106，其中具有一个声音传送 器107a和一个RF线圈108a。外壳106具有一个接触壁106a用来与病人的皮 肤进行接触。在接触壁106a的一部分，形成了一个粘结层109，用来将诊断贴 粘贴到病人的皮肤上，而剩余的接触壁的部分则暴露于病人的皮肤。声音发射 器107a粘贴在靠近壁106a暴露部分的外壳106中的壁106a上，可以让声音 或超声能量穿过接触壁106a。在声音发射器107a的另外一侧，提供了一种声 音基底材料107m，可以吸收向基底材料107m的方向传送的声音能量。一般 情况下，在接触壁106a的暴露部分的外侧会涂抹胶水或其他声音传导/耦合材 料。声音发射器107a的输出连接到了导线100a上，导线通过伸出外壳106的 导线导管100连接到外部记录器105上。RF线圈108a通过导线也从导线管100 连接到了外部记录器105上。诊断贴102、103和104具有类似的结构。As shown in Figure 2, diagnostic patch 101 includes a plastic housing 106 having an acoustic transmitter 107a and an RF coil 108a therein. The housing 106 has a contact wall 106a for contacting the patient's skin. In a portion of the contact wall 106a, an adhesive layer 109 is formed for affixing the diagnostic patch to the patient's skin, while the remaining portion of the contact wall is exposed to the patient's skin. The sound emitter 107a is affixed to the wall 106a in the housing 106 near the exposed portion of the wall 106a, allowing sound or ultrasonic energy to pass through to contact the wall 106a. On the other side of the sound emitter 107a, there is provided an acoustic base material 107m which can absorb sound energy transmitted in the direction of the base material 107m. Typically, glue or other sound conducting/coupling material will be applied to the outside of the exposed portion of contact wall 106a. The output of the sound emitter 107a is connected to a lead 100a which is connected to an external recorder 105 through a lead guide 100 protruding from the housing 106. RF coil 108a is also connected from conduit 100 to external recorder 105 by wire. Diagnostic stickers 102, 103 and 104 have a similar structure.
如图3和4所示，胶囊110包括一个液体无法渗透的和具有气密性的胶囊 主体111。整体来看，本发明的胶囊的尺寸可以保证其能够被服下，并穿过肠 道。对于成年人来说，需要对胶囊的优选实施例进行尺寸设置，将其长度设定 在1.5到2.5厘米之间，直径为8毫米以下。对于儿童和动物，胶囊的尺寸可 按照实际情况进行合理设置。胶囊主体111含有封闭电路，可以在胶囊穿过肠 道的时候，防止电路受到体液的破坏。胶囊主体111的至少一部分要用超声传 导擦了来制作，以便于在人体中进行使用，此类材料包括医用级塑料，如聚乙烯。在塑料外壳中嵌有一个不透射线标记，可以通过外部的成像源来定位装置， 可以确定其位置。胶囊主体111可以用可溶性外壳(没有显示)进行包裹。外 壳可以用适当的可溶性材料制作，例如可溶解的明胶或肠道涂层，这些涂层可 以被胃部和肠道内的体液所融化。此类材料可以根据pH值进行选择性溶解， 从而让外壳在胶囊110穿过高酸性的胃部并计入中性的小肠之后被溶解。胶囊 主体111包括一个半球状的后端131和一个半球状的前端132。后端131包括 一个内端表面131a。前端132包括一个内端表面132a。可溶性胶囊110的整 体构造是圆柱形35，形成了光滑的胶囊外表面。As shown in Figures 3 and 4, the capsule 110 includes a capsule body 111 which is liquid-impermeable and air-tight. Overall, the size of the capsule of the present invention is such that it can be swallowed and passed through the intestinal tract. For adults, the preferred embodiment of the capsule needs to be sized to have a length between 1.5 and 2.5 cm and a diameter of up to 8 mm. For children and animals, the size of the capsule can be reasonably set according to actual conditions. The capsule body 111 contains a closed circuit that prevents the circuit from being damaged by bodily fluids as the capsule passes through the intestinal tract. At least a part of the capsule body 111 will be made with ultrasonic conductive wipes, so that it can be used in the human body, such materials include medical grade plastics, such as polyethylene. A radiopaque marker embedded in the plastic housing allows the device to be located by an external imaging source, allowing its position to be determined. The capsule body 111 may be wrapped with a dissolvable shell (not shown). The casing can be made of suitable soluble materials such as soluble gelatin or enteric coatings that are melted by the body fluids of the stomach and intestines. Such materials can be selectively soluble based on pH, allowing the shell to dissolve after the capsule 110 passes through the highly acidic stomach and enters the neutral small intestine. The capsule body 111 includes a hemispherical rear end 131 and a hemispherical front end 132. The rear end 131 includes an inner end surface 131a. Front end 132 includes an inner end surface 132a. The overall configuration of the dissolvable capsule 110 is cylindrical 35, forming a smooth outer capsule surface.
胶囊110包含一个RF线圈135，用来传送和接收RF信号，和声音发射器 136a、136b和136c，这些传送器位于胶囊主体111中。声音发射器136a和136b 分别位于内端表面132a和131a上，并用声音传送/耦合材料对传送器136a和 136b与末端表面132a、131a之间的空隙进行了填充，以保证传送器能够通过 胶囊主体111向周边的组织或材料传送声音和超声波。声音发射器136c具有 圆柱形状，围绕胶囊的内周长进行扩张。用类似的声音传送/耦合材料填充了 声音发射器136c和胶囊主体111内壁之间的空隙。声音发射器136a-c进行了组合安排，从而对声音信号进行整体的定向发送。The capsule 110 includes an RF coil 135 for transmitting and receiving RF signals, and sound transmitters 136a, 136b and 136c, which are located in the capsule body 111. The sound emitters 136a and 136b are located on the inner end surfaces 132a and 131a respectively, and the gaps between the transmitters 136a and 136b and the end surfaces 132a, 131a are filled with sound transmission/coupling material to ensure that the transmitters can pass through the capsule body. 111 transmits sound and ultrasound to surrounding tissues or materials. The sound emitter 136c has a cylindrical shape that expands around the inner perimeter of the capsule. The gap between the sound emitter 136c and the inner wall of the capsule body 111 is filled with a similar sound transmitting/coupling material. The sound emitters 136a-c are arranged in combination to provide an overall directional transmission of sound signals.
发射器136a包括一个压电晶体137，位于电极板138之间，当通电的时候， 会让晶体按照超声频率震动。吸声材料139，如柔性聚合物中的氧颗粒，如环 氧基体钨粉，被放到了传送器136a的背面，来吸收与末端表面132a方向相反 的声音传递。声音发射器136b和136c的构造和材料与136a类似。其他声音 传送器的配置可以用来提供相对定向的声音信号传送。RF线圈135与声音传 送器136a、136b和136c通过电气连接与电子装置113进行了链接，该装置通 过电池114供电。Transmitter 136a includes a piezoelectric crystal 137, positioned between electrode plates 138, which, when energized, causes the crystal to vibrate at an ultrasonic frequency. Acoustic absorbing material 139, such as oxygen particles in a flexible polymer, such as tungsten epoxy powder, is placed on the back of the transmitter 136a to absorb sound transmission in the direction opposite to the end surface 132a. Sound emitters 136b and 136c are similar in construction and materials to 136a. Other acoustic transmitter configurations may be used to provide relatively directional acoustic signal transmission. RF coil 135 and sound transmitters 136a, 136b and 136c are linked by electrical connections to electronics 113, which is powered by battery 114.
一个延长元件115固定到了胶囊主体背端131上。第一个和第二个双极电 极116、117位于延长元件115上，第二个双极电极117与第一个电极116在 电气方面是相对立的。延长元件115最好是用弹性材料制作，如捏钛合金。An elongate element 115 is secured to the back end 131 of the capsule body. First and second bipolar electrodes 116,117 are located on the elongate member 115, the second bipolar electrode 117 being electrically opposed to the first electrode 116. The extension member 115 is preferably made of elastic material, such as pinched titanium alloy.
胶囊主体111还包括一个位于胶囊主体111上的pFl传感器133。pFl传感 器133是用不同类金属制作的，如氯化银以及锑，这种材料能够感应到pFI中 的差异，并且会将感应到的结果转化成经过校对的电信号。pFl传感器通过导 线与电子装置113相连。The capsule body 111 also includes a pF1 sensor 133 located on the capsule body 111. The pFl sensor 133 is made of different metals, such as silver chloride and antimony, which can sense the difference in pFI and convert the sensed result into a calibrated electrical signal. The pFl sensor is connected to electronics 113 by wires.
如图5所示，电子装置113是一个芯片，其中包括各种可选连接器，因此， 可以按照多种诊断和治疗胶囊配置来使用。胶囊的电子装置113包括一个微处 理器或控制器112，用来控制电子装置的运行；一个内部时钟121；和电池装 置114，例如一对锂碘电池，用来为电路113的各部件供电。因此，控制器122 和电池装置114连接到了电路的主要部件上，如该领域的普通技术人员所知。As shown in Figure 5, the electronics 113 is a chip that includes various optional connectors and, therefore, can be used in a variety of diagnostic and therapeutic capsule configurations. The electronics 113 of the capsule include a microprocessor or controller 112 for controlling the operation of the electronics; an internal clock 121; Accordingly, the controller 122 and the battery unit 114 are connected to the main components of the circuit, as known to those of ordinary skill in the art.
控制器122与只读存储器ROM 123相连，其中含有控制器122的程序指 令，以及其他固定存储的信息，可以让微处理器/控制器122进行运行。控制 器122可以通过地址总线123a将存储器引导到ROM123中，且ROM123能够 通过数据总线123b将存储的程序指令提供到控制器122。Controller 122 is connected to read-only memory ROM 123, which contains program instructions for controller 122, as well as other permanently stored information, to allow microprocessor/controller 122 to operate. Controller 122 can direct memory into ROM 123 via address bus 123a, and ROM 123 can provide stored program instructions to controller 122 via data bus 123b.
声音发射器136a的电极板138是通过控制器122控制的振荡器137a通电 的，可以生成所需的声波输出。与之类似的是，声音发射器136b和136c的电 极板是通过振荡器137b和137c供电的，并通过控制器122进行控制。控制器 122控制RF线圈135，该线圈既可以发送RF追踪信号也可以用作一个遥测装 置，将数据发送到记录器105上。RF线圈135可以向诊断贴101、102、103 和104中的RF线圈108a-d发射信号，或从这些线圈接收信号。为了进行追踪， 控制器122将分别在固定的时间间隔使用RF线圈135和声音发射器136a-136c 中的至少一个来要求发射RF信号和声音信号。控制器的命令将加入RF信号 传送和声音信号启动之间的预设时间间隔。此类时间间隔(可能是零)将会纳 入到记录器105中，来确定声波的传送时间。在优选实施例中，胶囊的声音发 射器136a-136c能够立即传送声音信号，或在RF参考信号之后发送一个规定 的时间。声音发射器136a将在RF信号之后的规定时间发射第一个信号，且第 二和第三声音发射器136b和136c将会在RF信号之后的规定时间分别发送第 二个和第三个信号，而且信号之间要有足够的时间间隔，从而让声音信号具有 差异。另外，第二个和第三个声音信号可以根据第二个和第三个差异RF信号 进行参考。Electrode plate 138 of sound emitter 136a is energized by oscillator 137a controlled by controller 122 to generate the desired acoustic output. Similarly, the electrode plates of sound emitters 136b and 136c are powered by oscillators 137b and 137c and controlled by controller 122. Controller 122 controls RF coil 135, which can either send RF tracking signals or act as a telemetry device, sending data to recorder 105. RF coil 135 may transmit signals to, or receive signals from, RF coils 108a-d in diagnostic patches 101, 102, 103, and 104. For tracking, the controller 122 will request the transmission of an RF signal and an acoustic signal at regular intervals using at least one of the RF coil 135 and the acoustic transmitters 136a-136c, respectively. Commands from the controller will be added with a pre-set time interval between the transmission of the RF signal and the activation of the audible signal. Such time intervals (possibly zero) will be entered into the recorder 105 to determine the transit time of the sound waves. In a preferred embodiment, the capsule's sound transmitters 136a-136c are capable of transmitting the sound signal immediately, or a specified time after the RF reference signal. Sound transmitter 136a will transmit a first signal at a specified time after the RF signal, and second and third sound transmitters 136b and 136c will transmit a second and third signal, respectively, at a specified time after the RF signal, And there should be enough time interval between the signals, so that the sound signal has a difference. Alternatively, the second and third sound signals may be referenced to the second and third differential RF signals.
当RF线圈135收到外部遥测信号的时候，缓冲振荡器119将被关闭。RF 线圈135收到的遥测信号可以用探测器电路119a进行探测，并且发送到微处 理器122上。探测器电路119a最好能够根据为遥测信号使用的调制来选择。When the RF coil 135 receives an external telemetry signal, the buffer oscillator 119 will be turned off. Telemetry signals received by RF coil 135 may be detected by detector circuit 119a and sent to microprocessor 122. The detector circuit 119a is preferably selectable according to the modulation used for the telemetry signal.
一个或多个传感器127a(压力)、127b(pH值)、127c(光学)、127d(温 度)和116、117(电极)可以通过A/D转换器(配有放大器)126a、126b、 126c、126d、126e与控制器122进行连接，这些转换器可以将典型的模拟电信 号转化成数字信号。这些类型的适当传感器在该领域一般都是已知的，且可以 安装在胶囊主体111的内部或外部。用来实现刺激的电极116、117也可以用 来感应电活动或阻抗。One or more sensors 127a (pressure), 127b (pH), 127c (optical), 127d (temperature) and 116, 117 (electrodes) can be connected via A/D converters (equipped with amplifiers) 126a, 126b, 126c, 126d, 126e are connected to the controller 122, and these converters can convert typical analog electrical signals into digital signals. Suitable sensors of these types are generally known in the art and may be mounted inside or outside the capsule body 111. The electrodes 116, 117 used to effect stimulation may also be used to sense electrical activity or impedance.
控制器122通过一个地址总线120a与RAM 120相连，用来对RAM120 中的位置进行寻址，还可以通过一个双向数据总线120b与RAM120进行连接， 用来收发来自RAM120的信息。RAM120包括事件存储器124，可以暂时存储 传感器127a-127d以及电极116、117记录的数据。RAM120还可以包括一个可 编程存储器125，该存储器可以在胶囊位于肠道内的时候通过遥感技术进行编 程，从而提供治疗协议。存储在事件存储器124中的数据可以间歇式地通过 RF线圈135，用摇杆技术作为数据突发发送至外部线圈138a-d(图5)，从而 节省电力。存储在可编程存储器125中的数据可以包括对电刺激运行模式的说 明(如波形、刺激类型：如步测，包括收缩或其他类型)，以及各种程序参数(如何时用药或进行电刺激)。此类编程可以根据感应到的信息来完成，或由 外部控制器自动完成，或按照治疗医师的要求来完成。The controller 122 is connected to the RAM 120 through an address bus 120 a for addressing the locations in the RAM 120 , and can also be connected to the RAM 120 through a bidirectional data bus 120 b for sending and receiving information from the RAM 120 . RAM 120 includes event memory 124 that can temporarily store data recorded by sensors 127a-127d and electrodes 116,117. RAM 120 can also include a programmable memory 125 that can be programmed via telemetry while the capsule is in the intestinal tract to provide therapy protocols. Data stored in the event memory 124 can be intermittently passed through the RF coil 135, using rocker technology as data bursts to the external coils 138a-d (FIG. 5), thereby saving power. The data stored in the programmable memory 125 may include a description of the mode of operation of the electrical stimulation (e.g., waveform, type of stimulation: e.g. pacing, including contraction or other types), and various program parameters (when to administer medication or to perform electrical stimulation) . Such programming can be done based on sensed information, or automatically by an external controller, or at the request of the treating physician.
控制器122与一个缓冲振荡器119相连，可以提供需要从RF线圈135发 送的RF信号。RF信号的频率最好是100kHz到5MHz，从而让信号能够通过 组织进行传送。35控制器122控制振荡器119，并且能够提供各种数据，例如 感应到的数据，如压力、pH值、阻抗、电活动等，从而与需要通过RF线圈 135发送的RF信号进行调制。控制器122还可以通过刺激驱动器188和耦合 电容器116a、117a分别与刺激电极116、117相连。可以通过与本文所述方法 类似的方式提供电刺激。刺激模式和参数可以通过一个外部装置进行编程或设 置，该装置可以通过遥测方式发送参数。The controller 122 is connected to a buffered oscillator 119 which provides the RF signal to be sent from the RF coil 135. The frequency of the RF signal is preferably 100 kHz to 5 MHz to allow the signal to be transmitted through the tissue. The controller 122 controls the oscillator 119 and can provide various data, such as sensed data such as pressure, pH, impedance, electrical activity, etc., to be modulated with the RF signal that needs to be sent through the RF coil 135. The controller 122 may also be connected to the stimulation electrodes 116, 117 via the stimulation driver 188 and the coupling capacitors 116a, 117a, respectively. Electrical stimulation can be provided in a manner similar to the methods described herein. Stimulation patterns and parameters can be programmed or set via an external device that can send parameters via telemetry.
电池114将其输出供应到一个直流-直流转换器130，来提供更高的电压， 该转换器用来获得电刺激脉冲。直流-直流转换器130是一种传统转换器，能 够提供15到20伏特的输出电压。另外，电路113可包括一个或多个驱动器 128a、128b、128c、128d，用来驱动各种装置，例如诊断或治疗机电装置，如 用于药物供应、活体组织检查、内容取样或标记释放的控制阀、电磁阀等。控 制器122可以根据ROM123中预设的程序、存储在RAM 120中的感应参数及 /或通过遥测技术从记录器105或诊断贴101-104中的RF线圈108a-d收到的信 号向驱动器128a-d发送信号。电路还可以包括一个步进驱动器129，该驱动器 与步进电机相连，可以驱动成像装置(如诊断超声装置)或启动活体组织检查 装置等。The battery 114 supplies its output to a DC-DC converter 130 to provide a higher voltage, which is used to obtain electrical stimulation pulses. DC-DC converter 130 is a conventional converter capable of providing an output voltage of 15 to 20 volts. Additionally, the circuitry 113 may include one or more drivers 128a, 128b, 128c, 128d for driving various devices, such as diagnostic or therapeutic electromechanical devices, such as for the control of drug delivery, biopsy, content sampling, or label release valves, solenoid valves, etc. The controller 122 can communicate with the driver 128a according to the preset program in the ROM 123, the sensing parameters stored in the RAM 120, and/or the signals received by the recorder 105 or the RF coils 108a-d in the diagnostic stickers 101-104 by telemetry. -d Send a signal. The circuit can also include a stepper driver 129, which is connected to the stepper motor and can drive an imaging device (such as a diagnostic ultrasound device) or activate a biopsy device, etc.
虽然说明书中对本发明的实施方式进行了说明，但这些实施方式只是作为 提示，不应限定本发明的保护范围。在不脱离本发明宗旨的范围内进行各种省 略、置换和变更均应包含在本发明的保护范围内。Although the embodiments of the present invention have been described in the description, these embodiments are only as hints and should not limit the protection scope of the present invention. Various omissions, substitutions and changes within the scope not departing from the gist of the present invention should be included in the protection scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710057828.4ACN107638624A (en) | 2017-01-23 | 2017-01-23 | A kind of system that medicine is provided to intestines and stomach |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710057828.4ACN107638624A (en) | 2017-01-23 | 2017-01-23 | A kind of system that medicine is provided to intestines and stomach |
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| CN107638624Atrue CN107638624A (en) | 2018-01-30 |
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| TA01 | Transfer of patent application right | Effective date of registration:20200826 Address after:No.2101, building 5, xiangxieyuan, coastal Lishui Jiayuan, No.8 Daojiao Road, Daojiao Town, Dongguan City, Guangdong Province Applicant after:Zhong Xin Address before:436070 Optics Valley joint development science and Technology City, Gedian Development Zone, Huarong District, Hubei, Ezhou C3-6 Applicant before:WISEHEALTH, Ltd. | |
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