A kind of ophthalmology imaging diagnosis systemTechnical field
The present invention relates to a kind of ophthalmology imaging diagnosis systems.
Background technique
Optical coherent chromatographic imaging (OCT, Optical Coherence Tomography) technology has high-resolution,High image taking speed, it is not damaged the features such as, wherein the OCT device for possessing ophthalmic diagnosis is that OCT technology one of is most widely applied.
Refering to Figure 1, describe a kind of OCT optical path in patent US8427654, especially describe a kind of eyeground andThe switching method of anterior ocular segment imaging optical path.By moving into a lens group in OCT optical path, make the lens group focal plane close to eyesPosition is moved to anterior ocular segment from internal system.Such method advantage is that structure is relatively easy, but deposits anterior ocular segment visual field after handoverThe control of small and anterior ocular segment light angle is not flexible.
It please refers to shown in Fig. 2, a kind of OCT system for making eyes refraction index test is described in patent US20080106696A1System, especially contains the two kinds of imaging patterns in eyeground and anterior ocular segment.It is similar with patent US8427654, by being moved in OCT optical pathEnter a lens group, makes the focusing position of focal plane of ocular lens attachment, be moved to anterior ocular segment from internal system.
It please refers to shown in Fig. 3,4 and 5, a kind of OCT system and imaging method is described in patent CN102438505ZHONG,Also include a kind of anterior ocular segment and oculi posterior segment switching mode, by moving into a dichroscope, while will be close to the reflection of scanning mirrorMirror is rotated by 90 ° direction, and anterior ocular segment optical path is replaced oculi posterior segment optical path, accesses subsequent optical path acquisition system.Wherein, the dotted line side 1a1Frame is fundus imaging part, and 1b1 is dashed rectangle fundus imaging part.
It please refers to shown in Fig. 6, a kind of OCT system is described in patent US2008/0106696A1, in fundus imaging modeUnder setting, by the way that another ocular lens is added in former eye position attachment, former conjugation is made to switch to conjugation to eye to the optical path on eyegroundProsthomere.But such method has that fixation optical path meeting image quality is impacted, originally clear for eyeball measurandFixation target can thicken after being switched to anterior ocular segment.
In the existing market OCT, substantial portion of product covers anterior ocular segment and oculi posterior segment scanning function simultaneously, and is directed toThe switching of anterior ocular segment imaging function and fundus imaging function is had nothing in common with each other mode.
Wherein, external switching mode such as patent US2008/0106696A1 needs user to be manually operated, and convenience is poor,And it is difficult to take into account interior fixation lamp；Some internal switching mode such as CN102438505ZHONG, are by multi-disc plane reflection opticsElement carries out the switching between two independent optical paths；There are also internal switching mode such as US8427654 andUS20080106696A1, by the way that system intermediate image plane is moved to mode at the moment, available fields are smaller, and design in thisIt is difficult to realize telecentric imaging, limits the ability of systematic quantification measurement.
Therefore, it is necessary to a kind of new ophthalmology imaging diagnosis systems to solve the above problems.
Summary of the invention
To solve defect of the existing technology, a kind of ophthalmology imaging diagnosis system is provided.
In order to achieve the above objectives, the present invention adopts the following technical scheme that:
A kind of ophthalmology imaging diagnosis system, including ocular lens and OCT image module, the OCT image module includes eyegroundOCT image mode and anterior ocular segment OCT image mode；
OCT image module has the first intermediate image plane in the eyeground OCT image mode, and first intermediate image plane is located atBetween the ocular lens and OCT image module；
Lens group, the OCT are set in the inside optical path of the OCT image module of the eyeground OCT image modeImage-forming module has the second intermediate image plane, and second intermediate image plane is located in the OCT image module, the OCT image mouldThe conjugate position of the imaging optical path aperture diaphragm of block between the ocular lens and OCT image module, obtain anterior ocular segment OCT atAs mode.
It further, further include the first dichronic mirror, the one of first dichronic mirror is arranged in the OCT image moduleSide, the ocular lens are arranged on the reflected light path of first dichronic mirror, and first intermediate image plane is located at the ocular lensAnd first between dichronic mirror, the conjugate position of the imaging optical path aperture diaphragm of the OCT image module be located at the ocular lens andBetween first dichronic mirror.
Further, in the eyeground OCT image mode and anterior ocular segment OCT image mode of the OCT image module, eyeThe light path ratio of bottom OCT image mode and anterior ocular segment OCT image mode meets following formula requirement:
In formula, OPLretinaRepresent optical path length under the mode of eyeground, OPLcorneaRepresent optical path length under anterior ocular segment mode.It adoptsIn the handoff procedure that can guarantee OCT fundus imaging mode and anterior ocular segment imaging pattern with above-mentioned design, 24mm standard people is consideredUnder the premise of eye length, after being guaranteed before the handover by optical design, sample arm optical path length is approximate consistent.
It further, further include the second dichronic mirror and eyeground SLO scanning laser ophthalmoscope module, second dichronic mirrorIt is arranged on the transmitted light path or reflected light path of first dichronic mirror, the light between second dichronic mirror and the first dichronic mirrorRoad is provided with the first relay, and the anti-of second dichronic mirror is arranged in the eyeground SLO scanning laser ophthalmoscope moduleIt penetrates on optical path or transmitted light path.
It further, further include third dichronic mirror, fixation target module and anterior ocular segment photographing module, the third color separationMirror is arranged on the transmitted light path or reflected light path of second dichronic mirror, sets between the third dichronic mirror and the second dichronic mirrorIt is equipped with the second relay, the fixation target module is arranged on the transmitted light path or reflected light path of the third dichronic mirror,The anterior ocular segment photographing module is arranged on the reflected light path or transmitted light path of the third dichronic mirror.
It further, further include OCT galvanometer, the OCT galvanometer is arranged in the OCT image module far from described firstOne end of dichronic mirror.
Further, the OCT image module includes the first lens group and the third lens, and first lens group includesFirst lens and the second lens, for first lens close to the ocular lens, second lens are described far from the ocular lensThe side of first lens group far from the ocular lens is arranged in the third lens.First lens and the second lens are respectively biconvexLens and meniscus shaped lens can also be respectively biconvex positive lens and meniscus shaped lens.The third lens are biconvex lens or bent moonShape lens.
Further, the lens group is arranged between second lens and the third lens.
Further, the lens group includes the second lens group and the third lens group, second lens group and thirdLens group is located at the two sides of second intermediate image plane.
Further, second lens group includes the 4th lens, and the third lens group includes the 5th lens and theSix lens, the 5th lens and the 6th lens are successively far from second intermediate image plane.4th lens be plano-convex lens, the 5thLens are negative-power lenses, and the 6th lens are falcate positive lens.
Further, second lens group include the two or four lens and the two or five lens, the two or four lens andTwo or five lens successively far from second intermediate image plane, the third lens group include the two or six lens, the two or seven lens andTwo or eight lens, the two or six lens, the two or seven lens and the two or eight lens are successively far from second intermediate image plane.ItsIn, specifically, the two or four lens 24 and the two or five lens 25 are meniscus shaped lens, and mould is being imaged close to anterior ocular segment in the face center of circleIntermediate image plane side under formula.Two or six lens 26 are double-concave negative lens, and the two or seven lens 27 are meniscus shaped lens, and the two can beCurvature of field compensation is carried out close to intermediate image position.Two or eight lens 28 are biconvex positive lens.
The utility model has the advantages that ophthalmology imaging diagnosis system of the invention, which has both, realizes what OCT fundus imaging and OCT anterior ocular segment were imagedFunction, and realize the inside switching of the two.From fundus imaging be switched to anterior ocular segment imaging after, increased one newly in OCT image moduleA second intermediary image, such method make light be incident on anterior ocular segment angle control it is more flexible, anterior ocular segment visual field resolution ratio refers toMark can be improved.The present invention inside the optical path of OCT image module using switching simultaneously, to other systems optical path in handoff procedureDo not influence.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of OCT optical path in patent US8427654；
Fig. 2 is the structural schematic diagram for making the OCT system of eyes refraction index test in patent US20080106696A1；
Fig. 3 is the first structure diagram of OCT system in patent CN102438505ZHONG；
Fig. 4 is the second structural schematic diagram of OCT system in patent CN102438505ZHONG；
Fig. 5 is the third structural schematic diagram of OCT system in patent CN102438505ZHONG；
Fig. 6 is the structural schematic diagram of OCT system in patent US2008/0106696A1；
Fig. 7 is the optical system diagram of first embodiment of the invention；
Fig. 8 is the optical system diagram of second embodiment of the invention；
Fig. 9 is switching OCT image module section microscope group in first embodiment of the invention, completes the eyeground OCT and anterior ocular segmentThe structure chart of switching；
Figure 10 is the whole microscope groups for switching OCT image module in first embodiment of the invention, completes the eyeground OCT and at the momentSave the structure chart of switching；
Figure 11 is switching OCT image module section microscope group in second embodiment of the invention, completes the eyeground OCT and anterior ocular segmentThe structure chart of switching；
Figure 12 is the whole microscope groups for switching OCT image module in second embodiment of the invention, completes the eyeground OCT and at the momentSave the structure chart of switching.
Specific embodiment
Below in conjunction with detailed description of the invention by specific embodiments.
The present invention is ophthalmology imaging diagnosis system, and the inside switching method of proposition, user's operation is simply.In view of testedObject diopter is different, in order to ensure fixation system can blur-free imaging, be both needed to progress Diopter accommodation on eyeground and at the moment.This hairBright use switches inside OCT optical path, does not influence in handoff procedure on fixation system light path.
Present invention realization is after being switched to anterior ocular segment OCT image from eyeground OCT image, image position among OCT optical path Central PlainsWhile constant, an intermediary image has been increased newly, the angle control that such method makes light be incident on anterior ocular segment is more flexible, canTo realize telecentric imaging.And anterior ocular segment visual field resolution ratio index can be improved.
Diagnostic system based on ophthalmology OCT technology described in the embodiment of the present invention, including OCT image module, laser scanning eyeBottom mirror (scanning laser ophthalmoscope) image-forming module, anterior ocular segment photographing module and fixation target module system.RespectivelyImage-forming module operation wavelength is different, is boundary by multiple dichroscopes, is completed according to the dichroism of dichroscope eachThe imaging of wave band and illumination functions.
Technical problems to be solved of the embodiment of the present invention: one, a kind of diagnostic system based on ophthalmology OCT technology and its are providedImaging method during realizing eyeground and anterior ocular segment OCT image function switch, guarantees other auxiliary positionings, diagnostic function not byIt influences, i.e. anterior ocular segment photographing module, the imaging of eyeground SLO scanning laser ophthalmoscope module and fixation module is unaffected；Two,After from eyeground, OCT is switched to anterior ocular segment OCT mode, OCT image inside modules have increased an intermediary image newly, and such method makes lightThe angle control that line is incident on anterior ocular segment is more flexible, and anterior ocular segment telecentric imaging may be implemented, and anterior ocular segment visual field resolution ratioIndex can be improved.
Ophthalmology imaging diagnosis system, including the two kinds of OCT image modes in eyeground and anterior ocular segment, under the OCT image mode of eyeground,By switching part or whole OCT image modules, completes eyeground to anterior ocular segment imaging pattern and switch.OCT image module is to connect meshAll non-planar optical elements between mirror and galvanometer.OCT image module, it is mobile by the microscope group of OCT optical path according to instruction, from onePattern switching is planted to another scan pattern.Anterior ocular segment imaging pattern is will increase in OCT image module with respect to fundus imaging modeOne intermediate image plane, and it is different from the intermediate image position of eyeground mode.
In OCT fundus imaging mode and anterior ocular segment mode, OCT galvanometer theoretical position is all theoretical under two kinds of imaging patternsAperture diaphragm position, and the position with eye pupil conjugation.The switching of eyeground and anterior ocular segment is actually approximate pictureThe switching in face and pupil face, the intermediate image face position in the present invention under OCT fundus imaging mode, in OCT anterior ocular segment imaging patternDown it is the approximate conjugate position of imaging optical path aperture diaphragm, i.e., equally completes the switching of image planes to pupil face.In addition it is incident on eyePreceding light is less parallel light, therefore intermediate image position is the back focal length position of approximate ocular lens under fundus imaging mode,It is switched to anterior ocular segment mode back aperture stop position and is also similar to the coincidence of eyepiece back focal length position, the telecentricity of anterior ocular segment is realized with thisImaging.The eyeground OCT and anterior ocular segment imaging optical path handoff procedure, no planar optical elements participate in switching movement, or change position orDirection.The eyeground OCT and anterior ocular segment imaging optical path handoff procedure, without increasing or decreasing reflecting mirror or other planar waves in optical pathElement.
We can assume that having the first aperture diaphragm in the OCT image mode of eyeground, the first aperture diaphragm position is to sweepRetouch galvanometer position, and the first aperture diaphragm and eye pupil imaging conjugate；Have first in section OCT image mode before eyesAperture diaphragm and the second aperture diaphragm, the first aperture diaphragm position is constant, and the second aperture diaphragm is located at ocular lens and OCT image mouldBetween block, and the second aperture diaphragm and the first aperture diaphragm imaging conjugate.
The handoff procedure of OCT fundus imaging mode and anterior ocular segment imaging pattern, under the premise of considering 24mm standard human eye length,After being guaranteed before the handover by optical design, sample arm optical path length is approximate consistent.Therefore during this switching, reference arm canReduce or omit the compensation rate of coherence length.
When ophthalmology imaging diagnosis system carries out eyeground scanning imagery, near infrared light reaches galvanometer scanning device, then successivelyBy OCT fundus imaging module and ocular lens, and focus on eyeground.Light after fundus reflex and scattering, backtracking is extremelyGalvanometer.Its imaging optical path feature is to have an intermediate image face, this intermediate image plane between OCT fundus imaging module and ocular lensIt is approximately telecentric imaging.
When ophthalmology imaging diagnosis system carries out anterior ocular segment scanning imagery, near-infrared light source passes through galvanometer scanning device, entersOCT anterior ocular segment image-forming module and ocular lens, and focus on anterior ocular segment.Light after anterior ocular segment reflects and scatters, backtrackingTo galvanometer.Its imaging optical path feature are as follows: first, the identical position in OCT fundus imaging mode intermediate image face, section imaging before eyesBecome the approximate conjugate position of imaging optical path diaphragm under mode.Second, OCT anterior ocular segment image-forming module is relative to OCT fundus imagingModule, inside increase an intermediate image face newly.Third, having at least one before OCT anterior ocular segment module intermediate image plane or after intermediate image planeA negative-power lenses.
SLO scanning laser ophthalmoscope module in ophthalmology imaging diagnosis system, for using eyeground as the aid imaging of imageable targetModule.When SLO scanning imagery, infrared diaphanoscopy light source with OCT different-waveband successively passes through SLO galvanometer scanning device, SLOFundus imaging module and ocular lens, and focus on eyeground.Light after fundus reflex and scattering, backtracking to SLO scanGalvanometer.
Embodiment 1:
Ophthalmology imaging diagnosis system, as shown in fig. 7, OCT image module, SLO scanning laser ophthalmoscope image-forming module, at the momentIt saves photographing module and fixation target module shares ocular lens.The operating distance L1A of ocular lens to tested human eye is adjustable, in order to eyeProsthomere conjugate imaging system focuses；It is adjustable to the first two distance L2A to dichronic mirror DM01 after ocular lens, for human eyeHetero refraction difference compensates, and can specifically compensate for +/- 20 power range.
Ophthalmology imaging diagnosis system, as shown in fig. 7, OCT image module and SLO image-forming module are all in where the eyes optical axisThe same side of straight line；Anterior ocular segment photographing module is in the opposite other side.This embodiment advantage is two that SLO image-forming module passes throughOnly a piece of to dichronic mirror quantity, the influence to image quality and transmitance is minimum.
In the present embodiment between OCT image module and other functional modules, by DM01A long wave reflecting short transmission two toDichronic mirror carries out light path separating.R1A relaying group is SLO image-forming module, and anterior ocular segment photographing module and fixation module share microscope group.Between SLO image-forming module and anterior ocular segment photographing module, fixation module, two are transmitted to dichronic mirror by DM02A long wave reflecting shortCarry out light path separating.R2A relaying group is that anterior ocular segment photographing module and fixation module share microscope group.Anterior ocular segment photographing module and fixationObject module carries out light path separating to dichronic mirror by DM03A long wave reflecting short transmission two.
In the present embodiment OCT image module shown in Fig. 7 be eyeground mode, can by switch OCT image module section microscope group,The switching of two imaging patterns in the eyeground OCT and anterior ocular segment is completed, as shown in Figure 9.Two imaging patterns in the eyeground OCT and anterior ocular segmentSwitching can also complete the switching of two imaging patterns in the eyeground OCT and anterior ocular segment, such as by switching OCT image module whole microscope groupShown in Figure 10.
In OCT fundus imaging mode and anterior ocular segment mode, OCT galvanometer theoretical position is all theoretical under two kinds of imaging patternsAperture diaphragm position.The switching of eyeground and anterior ocular segment is actually the switching of approximate image planes and pupil face, in the present embodimentIntermediate image face position under OCT fundus imaging mode is the close of imaging optical path aperture diaphragm under OCT anterior ocular segment imaging patternLike conjugate position, i.e., equally complete the switching of image planes to pupil face.In addition the light being incident at the moment is less parallel light, thereforeIntermediate image position is the back focal length position of approximate ocular lens under fundus imaging mode, is switched to anterior ocular segment mode back aperture diaphragmPosition is also similar to the coincidence of eyepiece back focal length position, and the telecentric imaging of anterior ocular segment is realized with this.
Image-forming module is made of the first lens 11, the second lens 12, the third lens 13 under the mode of the eyeground OCT in Fig. 9.FirstLens 11 are biconvex lens, and wherein the face S1 should be near the optical surface of approximate diaphragm conjugate position after being switched to anterior ocular segment mode(the i.e. close optical surface with galvanometer and eye pupil conjugate position) easily generates stray light if the face lens S1 is designed as planeGhost image, therefore constrain S1 radius surface and be less than 300mm.Second lens 12 are meniscus shaped lens, and two surfaces bend towards OCT galvanometer reasonBy position.The third lens 13 are biconvex lens.The third lens 13 be near OCT galvanometer theoretical position, the second lens 12 andThe distance between the third lens 13 L0For the space that eyeground and anterior ocular segment switch, L0Meet following constraint condition:
Wherein, L1It is the first intermediate image plane at a distance from any point a on the first dichronic mirror, L2It is any on the first dichronic mirrorPoint a to galvanometer distance.
Image-forming module also wraps in addition to the first lens 11, the second lens 12, the third lens 13 under OCT anterior ocular segment mode in Fig. 9The 4th lens 14, the 5th lens 15, the 6th lens 16 are included to constitute.4th lens 14 are approximate plano-convex lens, almost plane be byThe one side of nearly anterior ocular segment intermediate image plane, the convex surface center of circle is in OCT galvanometer side.There is a negative light in the other side close to the intermediate image planeThe 5th lens 15 of focal power, to carry out curvature of field compensation near intermediate image plane.And the 5th lens 15 of negative power are in intermediary imageBetween face and OCT galvanometer theoretical position.The 6th close lens 16 are positive lens therewith, are meniscus shaped lens, the circle in two facesThe heart is far from OCT galvanometer side.
As shown in FIG. 9 and 10, it will increase an intermediary image in switching OCT to anterior ocular segment mode, OCT image moduleFace, and it is different from the intermediate image position of eyeground mode.Intermediate image face position under OCT fundus imaging mode, before OCTSave the approximate conjugate position under imaging pattern for imaging optical path aperture diaphragm.The eyeground OCT and anterior ocular segment imaging optical path handoff procedure,No planar optical elements participate in switching movement, or change position or orientation.The eyeground OCT and anterior ocular segment imaging optical path handoff procedure,Without increasing or decreasing reflecting mirror or other planar optical elements in optical path.It is cut on OCT module eyeground and anterior ocular segment scan patternProcess is changed, other modules are such as in system: SLO module, the imaging of anterior ocular segment photographing module and fixation target module and illumination pathIt is unaffected.
The present embodiment considers that 24mm standard human eye is long in the handoff procedure of fundus imaging mode and anterior ocular segment imaging patternUnder the premise of degree, after being guaranteed before the handover by optical design, sample arm optical path length is approximate consistent.Therefore in this handoff procedureIn, reference arm can reduce or omit the variable quantity of coherence length.
In formula, OPLretinaRepresent optical path length under the mode of eyeground, OPLcorneaRepresent optical path length under anterior ocular segment mode.
Embodiment 2:
Ophthalmology imaging diagnosis system, as shown in figure 8, OCT image module, SLO scanning laser ophthalmoscope image-forming module, at the momentIt saves photographing module and fixation target module shares ocular lens.The operating distance L1B of ocular lens to tested human eye is adjustable, in order to eyeProsthomere conjugate imaging system focuses；It is adjustable to the first two distance L2B to dichronic mirror DM01 after ocular lens, for human eyeHetero refraction difference compensates, and can specifically compensate for +/- 20 power range.
Ophthalmology imaging diagnosis system, as shown in figure 8, OCT image module, fixation module are all located with anterior ocular segment photographing moduleThe same side of straight line where the eyes optical axis, and anterior ocular segment photographing module is in the opposite other side.This embodiment advantage is eachModule distribution is compact, and system bulk is small.And DM02B is that long wave transmits shortwave reflection dichroscope, the optional range of product is big.
In the present embodiment between OCT image module and other functional modules, by DM01B long wave reflecting short transmission two toDichronic mirror carries out light path separating.R1B relaying group is SLO image-forming module, and anterior ocular segment photographing module and fixation module share microscope group.Between SLO image-forming module and anterior ocular segment photographing module, fixation module, shortwave reflection two is transmitted to dichronic mirror by DM02B long waveCarry out light path separating.R2B relaying group is that anterior ocular segment photographing module and fixation module share microscope group.Anterior ocular segment photographing module and fixationObject module carries out light path separating to dichronic mirror by DM03B long wave reflecting short transmission two.
Eyeground and anterior ocular segment switch in specific OCT image module, as shown in figure 11, image-forming module under the mode of the eyeground OCTIt is made of the first lens 21, the second lens 22, the third lens 23.First lens 21 are biconvex positive lens.Second lens 22 are curvedMoon-shaped lens are to balance the curvature of field, two face center of circle is far from OCT galvanometer theoretical position side.The third lens 23 are also curvedMoon-shaped lens, and two faces center of circle is close to OCT galvanometer theoretical position side.
Image-forming module also wraps in addition to the first lens 21, the second lens 22, the third lens 23 under OCT anterior ocular segment mode in Fig. 9Include the two or four lens 24, the two or five lens 25, the two or six lens 26, the two or seven lens 27, the two or eight lens 28.Two or four lens24 and second without lens 25 be meniscus shaped lens, and the face center of circle is in the intermediate image plane side under the anterior ocular segment imaging pattern.TheTwo or six lens 26 be double-concave negative lens, the two or seven lens 27 be meniscus shaped lens, the two can close to intermediate image position intoThe compensation of the row curvature of field.Two or eight lens 28 are biconvex positive lens.
In the present embodiment OCT image module shown in Fig. 8 be eyeground mode, can by switch OCT image module section microscope group,The switching of two imaging patterns in the eyeground OCT and anterior ocular segment is completed, as shown in figure 11.Or it can be whole by switching OCT image moduleMicroscope group completes the switching of two imaging patterns in the eyeground OCT and anterior ocular segment, as shown in figure 12.As shown in FIG. 9 and 10, switchingOCT will increase an intermediate image plane in OCT image module to anterior ocular segment mode, and not with the intermediate image position of eyeground modeTogether.In OCT fundus imaging mode and anterior ocular segment mode, OCT galvanometer theoretical position is all theoretical pore under two kinds of imaging patternsDiaphragm position.The switching of eyeground and anterior ocular segment is actually the switching of approximate image planes and pupil face, OCT in the present embodimentIntermediate image face position under the imaging pattern of bottom, it is total for the approximation of imaging optical path aperture diaphragm under OCT anterior ocular segment imaging patternYoke position equally completes the switching of image planes to pupil face.In addition light at the moment is incident on as less parallel light, therefore eyegroundIntermediate image position is the back focal length position of approximate ocular lens under imaging pattern, is switched to anterior ocular segment mode back aperture stop positionAlso it is similar to the coincidence of eyepiece back focal length position, the telecentric imaging of anterior ocular segment is realized with this.It is scanned on OCT module eyeground and anterior ocular segmentMode handover procedure, other modules are such as in system: SLO module, the imaging of anterior ocular segment photographing module and fixation target module and photographMingguang City road is unaffected.