A kind of novel lower limb artery sclerosis modelTechnical field
The present invention relates to medical apparatus technical field, and in particular to a kind of novel lower limb artery sclerosis model.
Background technology
Atherosclerotic occlusive disease is the common disease of blood vessel section, and one of focal disease of Gerontological Research Center, not onlyPatient's Charcot's syndrome is caused, and the violent rest pain occurred at pathological development to the later stage makes limbs be in sick hair-like state,Many patients finally have to amputation, severe patient's even threat to life.Clinically there is an urgent need to a kind of more satisfactory artery is hardChange Occlusion Model.But so far, except minority utilizes local intra-arterial scar caused by mechanical injuries and photosensitive endothelial injuriesProperty it is narrow, utilize limb ischemia mould caused by the inflammatory narrow and artery side shoot of local intra-arterial chemistry ligatures caused by laurateOutside type, more preferably animal model there is no.
The content of the invention
In view of the defects and deficiencies of the prior art, the present invention intends to provide one kind is simple in construction, reasonable in design, makesWith convenient novel lower limb artery sclerosis model.
To achieve the above object, the technical solution adopted by the present invention is：It includes arterial blood pipe die；Described arteriesMould is made up of inner membrance from inside to outside, middle film, elastic membrane and outer membrane；Narrow section is provided with described arterial blood pipe die；It is describedThe inwall of inner membrance be provided with calcification necrosis patch mould, the outer wall of outer membrane is provided with non-calcified property patch mould；In described inner membranceIt is provided with thrombus mould and cast-off cells mould；Described elastic membrane is provided with discontinuities；Hyperplasia structure is provided with described middle film.
Preferably, anomaly sxtructure section is provided with described inner membrance.
Preferably, it is provided with foam cells mould on described calcification necrosis patch mould and non-calcified property patch mould.
Preferably, described hyperplasia structure penetrates elastic membrane and inner membrance.
Preferably, described middle film, elastic membrane and outer membrane is sequentially sleeved on inner membrance.
Preferably, described arterial blood pipe die and non-calcified property patch mould are made up of silica gel, calcification necrosis patch mould, bloodBolt mould, cast-off cells mould and hyperplasia structure are made up of biogum.
During present invention operation, drug study at arteriotomy is carried out using animal, observation, animal is put to death within the 20th week and substantially solvesCut open in addition to atheromatous plaque is found in sustainer, the arteria renalis, tube chamber obvious stenosis, a large amount of atheromatous plaque shapes are found in bone femoral arteryInto；Light microscopic and Electronic Speculum are shown in typical artery sclerosis model pathological change：Luminal stenosis, thrombosis, interior pachyhymenia, endothelium are thinBorn of the same parents are come off, textural anomaly, and interior elastic membrane is interrupted or disappeared, and middle film proliferation of smooth muscle is tied through interior elastic membrane to subendothelial migrationForm hyperblastosis arrangement disorder, visible foam cell in patch, partially visible necrosis and calcification are formed.
After said structure, had the beneficial effect that caused by the present invention：A kind of novel lower limb artery of the present invention is hardChange model, vivid can demonstrate the occlusion of artery of lower extremity vascular sclerosis, provide study condition for arterial sclerosis treatment, the present invention hasHave the advantages that simple in construction, setting is reasonable, low manufacture cost.
Brief description of the drawings
Fig. 1 is the structure chart of the present invention.
Description of reference numerals：
Arterial blood pipe die 1, inner membrance 2, middle film 3, elastic membrane 4, outer membrane 5, narrow section 6, calcification necrosis patch mould 7, non-calcified property spotBlock mould 8, thrombus mould 9, cast-off cells mould 10, discontinuities 11, hyperplasia structure 12, anomaly sxtructure section 13, foam cells mould 14.
Embodiment
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existingThere is the required accompanying drawing used in technology description to be briefly described, it should be apparent that, drawings in the following description are only thisSome embodiments of invention, for those of ordinary skill in the art, without having to pay creative labor, may be used alsoTo obtain other accompanying drawings according to these accompanying drawings.
Referring to as shown in figure 1, present embodiment adopts the following technical scheme that：It includes arterial blood pipe die 1；DescribedArterial blood pipe die 1 is made up of inner membrance 2 from inside to outside, middle film 3, elastic membrane 4 and outer membrane 5；Set on described arterial blood pipe die 1There is narrow section 6；The inwall of described inner membrance 2 is provided with calcification necrosis patch mould 7, and the outer wall of outer membrane 5 is provided with non-calcified property spotBlock mould 8；Thrombus mould 9 and cast-off cells mould 10 are provided with described inner membrance 2；Described elastic membrane 4 is provided with discontinuities 11；InstituteHyperplasia structure 12 is provided with the middle film 3 stated.
Preferably, it is provided with anomaly sxtructure section 13 on described inner membrance 2.
Preferably, it is provided with foam cells mould 14 on described calcification necrosis patch mould 7 and non-calcified property patch mould 8.
Preferably, described hyperplasia structure 12 penetrates elastic membrane 4 and inner membrance 2.
Preferably, described middle film 3, elastic membrane 4 and outer membrane 5 are sequentially sleeved on inner membrance 2.
Preferably, described arterial blood pipe die 1 and non-calcified property patch mould 8 are made up of silica gel, calcification necrosis patch mould7th, thrombus mould 9, cast-off cells mould 10 and hyperplasia structure 12 are made up of biogum.
When present embodiment operates, drug study at arteriotomy is carried out using animal, observation, is put to death within the 20th week dynamicThing gross anatomy finds tube chamber obvious stenosis in addition to atheromatous plaque is found in sustainer, the arteria renalis, in bone femoral artery, a large amount of athero-Patch is formed；Light microscopic and Electronic Speculum are shown in typical artery sclerosis model pathological change：Luminal stenosis, thrombosis, interior pachyhymenia,Endothelial denudation, textural anomaly, interior elastic membrane are interrupted or disappeared, and middle film proliferation of smooth muscle is moved through interior elastic membrane to subendothelialMove, connective tissue proliferation arrangement disorder, visible foam cell in patch, partially visible necrosis and calcification are formed.
After said structure, had the beneficial effect that caused by present embodiment：One described in present embodimentKind novel lower limb artery sclerosis model, the occlusion of artery of lower extremity vascular sclerosis vivid can be demonstrated, treats and provides for arterial sclerosisStudy condition, present embodiment have the advantages that simple in construction, setting is reasonable, low manufacture cost.
The general principle and principal character and advantages of the present invention of the present invention has been shown and described above.The skill of the industryFor art personnel it should be appreciated that the present invention is not limited to the above embodiments, described in above-described embodiment and specification is explanationThe principle of the present invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, theseChanges and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims andIts equivalent thereof.