技术领域technical field
本发明涉及一种植入式眼压监测器。The invention relates to an implanted intraocular pressure monitor.
背景技术Background technique
青光眼是排名首位的不可逆性致盲眼病。目前全球约有6000万青光眼患者，其中840万双眼失明。在中国，40岁以上人群青光眼患病率约2.6％，其中致盲率约30％。青光眼发病机制复杂，普遍认为与眼内压力(有时也称“眼压”)增高有关，病理性眼压升高或波动导致视网膜神经节细胞死亡，视神经萎缩，视野逐渐缺损，直至全盲。Glaucoma is the leading irreversible blinding eye disease. There are currently about 60 million glaucoma patients worldwide, of whom 8.4 million are blind. In China, the prevalence of glaucoma among people over 40 years old is about 2.6%, and the blindness rate is about 30%. The pathogenesis of glaucoma is complicated, and it is generally believed that it is related to the increase of intraocular pressure (sometimes called "intraocular pressure"). The increase or fluctuation of pathological intraocular pressure leads to the death of retinal ganglion cells, atrophy of the optic nerve, and gradual loss of visual field until total blindness.
由于大多数青光眼患者在早期没有任何症状，患者往往因为视野缺损而前去就诊，但此时的视功能损害已很严重。在发达国家，有一半的青光眼患者不知道自己患有青光眼；而在发展中国家，有高达90％的青光眼患者对自己的疾病一无所知。中国青光眼患者的治疗率仅有10％～20％，很多患者都是到了晚期才来就诊，增加了治疗的难度和致盲的概率。因此，对于确诊为青光眼的患者，最有效的慢病管理策略就是通过滴眼液或手术等治疗手段来降低眼压，并保持其稳定，从而减缓和控制视觉损伤的进展，终生保留有用视力。Since most glaucoma patients do not have any symptoms in the early stage, patients often go to see a doctor because of visual field defect, but at this time the visual function damage is already very serious. In developed countries, half of glaucoma patients do not know they have glaucoma; in developing countries, up to 90% of glaucoma patients do not know their disease. The treatment rate of glaucoma patients in China is only 10% to 20%, and many patients come to see a doctor at an advanced stage, which increases the difficulty of treatment and the probability of blindness. Therefore, for patients diagnosed with glaucoma, the most effective chronic disease management strategy is to reduce intraocular pressure through eye drops or surgery and keep it stable, so as to slow down and control the progression of visual damage and preserve useful vision for life.
目前，医院大部分使用外部眼压检测器来测量眼压。这样的测量方法包括单点眼压测量和24小时眼压测量。单点测量包括压平式及压陷式两种，需要患者在医院门诊就诊时进行测量。其中Goldmann眼压计，是公认的眼压测量“金标准”。患者坐在裂隙灯前，点麻药及荧光素进行测量。通过压平角膜所需的重量来计算眼压。因此测量眼压值受到角膜厚度、曲率、弹性等生理指标的影响，与真实眼压值存在一定差异。一般认为，角膜厚度增加20-30m，测量眼压值偏高1mmHg。24小时眼压测量需要住院测量，每2-4小时一次，共12次，记录昼夜眼压波动，从而捕捉到门诊单点眼压测量未能捕捉到的眼压高值。特别是对于眼压波动较为明显的患者，可以调整优化用药时间。Currently, most hospitals use external tonometers to measure intraocular pressure. Such measurement methods include single-point tonometry and 24-hour tonometry. Single-point measurement includes applanation type and indentation type, which need to be measured when the patient visits the hospital. Among them, the Goldmann tonometer is recognized as the "gold standard" for intraocular pressure measurement. The patient sits in front of the slit lamp, anesthesia and fluorescein are administered for measurement. The intraocular pressure is calculated by the weight required to flatten the cornea. Therefore, the measured intraocular pressure value is affected by physiological indicators such as corneal thickness, curvature, and elasticity, and there is a certain difference between the measured intraocular pressure value and the real intraocular pressure value. It is generally believed that the corneal thickness increases by 20-30m, and the measured intraocular pressure value is 1mmHg higher. 24-hour intraocular pressure measurement requires inpatient measurement, once every 2-4 hours, a total of 12 times, and records diurnal intraocular pressure fluctuations, so as to capture high intraocular pressure values that cannot be captured by outpatient single-point intraocular pressure measurement. Especially for patients with obvious intraocular pressure fluctuations, the medication time can be adjusted and optimized.
发明内容Contents of the invention
然而，上述测量方法都需要在医生的辅助下完成，青光眼患者无法在日常生活状态下自行进行眼压测量，因此无法获得在两次就诊中间的日常生活状态下的眼压数据。一方面，对于医生而言，无法及时获得病人眼压数据开具相应的治疗方案甚至治疗方案有误，因此，处于上述治疗方式中的青光眼患者也都不同程度地出现视功能持续受损；另一方面，对于患者而言，由于缺少动态眼压数据作为反馈和激励，其配合执行治疗方案的依从性非常低，直接导致进一步的视野损害进展；同时导致下一次就诊时，医生无法判断视野损害进展是由于治疗方案需要优化调整还是患者未能有效执行治疗方案。However, the above measurement methods all need to be completed with the assistance of a doctor. Glaucoma patients cannot measure intraocular pressure by themselves in daily life, so it is impossible to obtain intraocular pressure data in daily life between two visits to the doctor. On the one hand, for doctors, it is impossible to obtain the patient's intraocular pressure data in time to prescribe a corresponding treatment plan or even the treatment plan is wrong. Therefore, glaucoma patients who are under the above treatment methods also suffer from continuous impairment of visual function to varying degrees; on the other hand On the one hand, for patients, due to the lack of dynamic intraocular pressure data as feedback and incentives, their compliance with the implementation of treatment plans is very low, which directly leads to further progression of visual field damage; at the same time, doctors cannot judge the progress of visual field damage at the next visit Is it because the treatment plan needs to be optimized or the patient fails to implement the treatment plan effectively.
本发明是有鉴于上述的现状而完成的，其目的在于，提供一种便于连续监测眼内压力的植入式眼压监测器。The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an implantable intraocular pressure monitor that facilitates continuous monitoring of intraocular pressure.
为此，本发明提供了一种植入式眼压监测器，其包括：一种植入式眼压监测器，其包括：密封腔体，其端部具有跟随压力强度变化而产生形变的形变膜；支撑部，其与所述密封腔体联接，并且定位所述密封腔体的所述形变膜的朝向；压力传感器，其设置在所述密封腔体内，并且通过检测所述形变膜的形变变化来获得压力信号；以及信号传输装置，其设置在所述支撑部内，并且将来自所述压力传感器的所述压力信号传输到外部。To this end, the present invention provides an implantable intraocular pressure monitor, which includes: an implantable intraocular pressure monitor, which includes: a sealed cavity, the end of which has a deformable membrane that deforms following changes in pressure intensity; a support part, which is coupled with the sealed cavity, and locates the direction of the deformable membrane of the sealed cavity; a pressure sensor, which is arranged in the sealed cavity, and detects the deformation change of the deformed membrane obtaining a pressure signal; and a signal transmission device provided in the support portion and transmitting the pressure signal from the pressure sensor to the outside.
在本发明所涉及的植入式眼压监测器中，由于眼压监测器的感测眼内压力的形变膜可以直接接触眼睛内的组织液，因此，能够直接测量眼内的压力。因此，相对于常规外部眼压检测器来测量眼压的方式而言，本发明的植入式眼压监测器，能够更高精度地测量眼内压力。In the implantable intraocular pressure monitor of the present invention, since the deformable membrane of the intraocular pressure monitor for sensing intraocular pressure can directly contact the interstitial fluid in the eye, the intraocular pressure can be directly measured. Therefore, compared with the method of measuring intraocular pressure with conventional external intraocular pressure detectors, the implantable intraocular pressure monitor of the present invention can measure intraocular pressure with higher precision.
另外，在本发明所涉及的植入式眼压监测器中，可选地，还包括处理电路，所述处理电路驱动所述压力传感器，并且对由所述压力传感器获得的压力信号进行处理。由此，能够获得噪声得到抑制的压力信号，从而提高眼内压力的测量精度。In addition, in the implantable intraocular pressure monitor of the present invention, optionally, a processing circuit is further included, the processing circuit drives the pressure sensor, and processes the pressure signal obtained by the pressure sensor. Thereby, a pressure signal with suppressed noise can be obtained, thereby improving the measurement accuracy of the intraocular pressure.
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述信号传输装置接收从外部输入的能量，并且将所述能量经由所述处理电路提供给压力传感器。另外，可选地，所述信号传输装置接收从外部输入的能量，并且将所述能量经由所述处理电路提供给压力传感器。通过信号传输装置，能够从外部接收能量，同时能够有效地将压力信号传输到外部。此外，所述信号传输装置可以是线圈。在这种情况下，能够经由无线的方式进行能量和数据的传输。In addition, in the implantable intraocular pressure monitor of the present invention, optionally, the signal transmission device receives energy input from the outside, and provides the energy to the pressure sensor via the processing circuit. In addition, optionally, the signal transmission device receives energy input from the outside, and provides the energy to the pressure sensor via the processing circuit. Through the signal transmission device, energy can be received from the outside, and at the same time, the pressure signal can be effectively transmitted to the outside. Furthermore, the signal transmission means may be a coil. In this case, energy and data can be transmitted wirelessly.
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述压力传感器是带有光栅的压力传感器，并且所述压力传感器包括激光器和光电探测器，所述光电探测器通过探测由所述激光器发出且经过所述光栅发生干涉的光的条纹变化来获得所述形变膜的形变变化，以计算出所述压力信号。在这种情况下，通过识别干涉光条纹的变化来获得形变膜的形变变化量，由此，能够高精度地测量形变膜的形变变化量，从而得到更加精确的压力信号。In addition, in the implantable intraocular pressure monitor involved in the present invention, optionally, the pressure sensor is a pressure sensor with a grating, and the pressure sensor includes a laser and a photodetector, and the photodetector The deformation change of the deformable membrane is obtained by detecting the fringe change of the light emitted by the laser and interfered by the grating, so as to calculate the pressure signal. In this case, the amount of deformation change of the deformable membrane is obtained by identifying the change of the interference light fringes, so that the amount of deformation change of the deformable membrane can be measured with high precision, thereby obtaining a more accurate pressure signal.
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述压力传感器与所述形变膜间形成内部腔体。In addition, in the implantable intraocular pressure monitor of the present invention, optionally, an internal cavity is formed between the pressure sensor and the deformable membrane.
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述内部腔体通过延伸至所述支撑部的管道与外部空气连通。在这种情况下，能够保证内部腔体与体外的空气压力保持均衡，由此能够抑制测量眼内压力时的压力信号漂移。In addition, in the implantable intraocular pressure monitor according to the present invention, optionally, the internal cavity communicates with external air through a pipe extending to the support part. In this case, it can be ensured that the air pressure in the internal cavity is kept equal to that outside the body, thereby suppressing the drift of the pressure signal when measuring the intraocular pressure.
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述密封腔体呈圆筒状。在这种情况下，能够更方便地制造密封腔体In addition, in the implantable intraocular pressure monitor of the present invention, optionally, the sealed cavity is cylindrical. In this case, it is more convenient to manufacture the sealed cavity
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述支撑部包括设置有所述信号传输装置的基部、以及从所述基部伸出的突起部，所述突起部与所述密封腔体固定联接。In addition, in the implantable intraocular pressure monitor according to the present invention, optionally, the support part includes a base part provided with the signal transmission device, and a protrusion protruding from the base part, and the protrusion part The part is fixedly connected with the sealed cavity.
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述基部呈圆盘状。In addition, in the implantable intraocular pressure monitor of the present invention, optionally, the base is disc-shaped.
另外，在本发明所涉及的植入式眼压监测器中，可选地，所述支撑部还设置有用于手术器械操作的安装孔。In addition, in the implantable intraocular pressure monitor of the present invention, optionally, the support part is also provided with mounting holes for operation of surgical instruments.
此外，在本发明所涉及的植入式眼压监测器中，可选地，所述远端套管与所述近端部分经由外管联接。由此，能够通过外管将远端套管与近端部分实现联接。In addition, in the implantable intraocular pressure monitor according to the present invention, optionally, the distal cannula is connected to the proximal part via an outer tube. Thereby, the coupling of the distal cannula and the proximal part can be achieved via the outer tube.
根据本发明，能够直接且精度高地测量眼内的压力。According to the present invention, the pressure in the eye can be measured directly and with high precision.
附图说明Description of drawings
图1是示出了本发明的实施方式所涉及的植入式眼压监测器的立体结构图。FIG. 1 is a perspective view showing an implantable intraocular pressure monitor according to an embodiment of the present invention.
图2是示出了本发明的实施方式所涉及的植入式眼压监测器另一立体结构图。Fig. 2 is another perspective view showing the implantable intraocular pressure monitor according to the embodiment of the present invention.
图3是示出了本发明的实施方式所涉及的植入式眼压监测器在眼睛的植入位置的示意图。Fig. 3 is a schematic diagram showing the implantation position of the implantable intraocular pressure monitor according to the embodiment of the present invention in the eye.
图4是示出了本发明的实施方式所涉及的植入式眼压监测器的密封腔体与支撑部分离的结构图。Fig. 4 is a structural view showing the separation of the sealed cavity and the supporting part of the implantable intraocular pressure monitor according to the embodiment of the present invention.
图5是示出了图1所示的植入式眼压监测器的内部结构示意图。FIG. 5 is a schematic diagram showing the internal structure of the implantable intraocular pressure monitor shown in FIG. 1 .
图6是本发明的实施方式所涉及的植入式眼压监测器的线圈的示意图。Fig. 6 is a schematic diagram of a coil of the implantable intraocular pressure monitor according to the embodiment of the present invention.
图7是示出了本发明的实施方式所涉及的植入式眼压监测器中的压力传感器的示意图。Fig. 7 is a schematic diagram showing a pressure sensor in the implantable tonometry monitor according to the embodiment of the present invention.
符号说明：Symbol Description:
1…植入式眼压监测器，2…眼睛，10…密封腔体，12…腔体侧壁，14…形变膜，16…馈通结构20…支撑部，22…基部，100…压力传感器，200…处理电路，16…馈通孔，300…线圈。1...implantable intraocular pressure monitor, 2...eye, 10...sealed cavity, 12...cavity side wall, 14...deformable membrane, 16...feedthrough structure 20...support, 22...base, 100...pressure sensor , 200...processing circuit, 16...feedthrough hole, 300...coil.
具体实施方式Detailed ways
以下，参考附图，详细地说明本发明的优选实施方式。在下面的说明中，对于相同的部件赋予相同的符号，省略重复的说明。另外，附图只是示意性的图，部件相互之间的尺寸的比例或者部件的形状等可以与实际的不同。Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. In the following description, the same reference numerals are given to the same components, and repeated descriptions are omitted. In addition, the drawings are only schematic diagrams, and the ratio of dimensions between components, the shape of components, and the like may be different from the actual ones.
图1是示出了本发明的实施方式所涉及的植入式眼压监测器的立体结构图。图2是示出了本发明的实施方式所涉及的植入式眼压监测器另一立体结构图。图3是示出了本发明的实施方式所涉及的植入式眼压监测器在眼睛的植入位置的示意图。FIG. 1 is a perspective view showing an implantable intraocular pressure monitor according to an embodiment of the present invention. Fig. 2 is another perspective view showing the implantable intraocular pressure monitor according to the embodiment of the present invention. Fig. 3 is a schematic diagram showing the implantation position of the implantable intraocular pressure monitor according to the embodiment of the present invention in the eye.
如图1和图2所示，本发明所涉及的植入式眼压监测器1(也称“眼压监测器1”)可以大致呈“T”字形结构。眼压监测器1包括密封腔体10和与密封腔体10联接的支撑部20。此外，尽管本实施方式示出了眼压监测器1呈“T”字形结构，但是本实施方式并没有特别限制眼压监测器1的形状，例如也可以是其他形状结构，比如圆柱形、抛物形、柱台状等。As shown in FIG. 1 and FIG. 2 , the implantable intraocular pressure monitor 1 (also referred to as "intraocular pressure monitor 1") of the present invention can be roughly in the shape of a "T" shape. The intraocular pressure monitor 1 includes a sealed cavity 10 and a support part 20 coupled with the sealed cavity 10 . In addition, although this embodiment shows that the intraocular pressure monitor 1 has a "T"-shaped structure, this embodiment does not particularly limit the shape of the intraocular pressure monitor 1, for example, it can also be other shapes and structures, such as cylindrical, parabolic shape, pedestal shape, etc.
在本实施方式中，密封腔体10内可以充填有气体，例如充填有氮气、氩气等惰性气体。另外，在眼压监测器1呈“T”字形结构的情况下，与密封腔体10联接的支撑部20(具体是支撑部20的外周区域)可以贴合在眼球的外表面。In this embodiment, the sealed cavity 10 may be filled with gas, such as nitrogen, argon and other inert gases. In addition, when the intraocular pressure monitor 1 has a "T" shape structure, the support part 20 coupled with the sealed cavity 10 (specifically, the peripheral area of the support part 20 ) can be attached to the outer surface of the eyeball.
本发明所涉及的眼压监测器1可以植入在眼睛的许多部位处以便直接测量眼内的压力强度。可植入的位置例如包括角膜内、前房、后房、玻璃体、视网膜上层空间、上层脉络膜、脉络膜上层空间、副结膜、巩膜外、巩膜内、眼周、小梁切除术部位、滤帘切除术部位，或睫状体分离术空间等。The intraocular pressure monitor 1 involved in the present invention can be implanted in many parts of the eye to directly measure the pressure intensity in the eye. Implantable sites include, for example, intracorneal, anterior chamber, posterior chamber, vitreous, supraretinal space, superior choroid, suprachoroidal space, accessory conjunctiva, extrasclera, intrasclera, periocular, trabeculectomy site, filter curtain resection Surgical site, or cyclodivision space, etc.
在本实施方式中，眼压监测器1可以植入在眼睛的前房，并且使密封腔体10的形变膜接触位于前房的眼内组织液。作为示例，图3示出了将眼压监测器1植入到眼睛2的前房2a的情形。在该示例中，通过将眼压监测器1植入在眼睛的前房，从而眼压监测器1能够直接测量眼内的压力强度。In this embodiment, the intraocular pressure monitor 1 can be implanted in the anterior chamber of the eye, and the deformable membrane of the sealed cavity 10 can be in contact with intraocular tissue fluid located in the anterior chamber. As an example, FIG. 3 shows the implantation of the tonometry monitor 1 in the anterior chamber 2 a of the eye 2 . In this example, the intraocular pressure monitor 1 can directly measure the pressure intensity in the eye by implanting the intraocular pressure monitor 1 in the anterior chamber of the eye.
在一些示例中，可以在眼压监测器1内设置电池(微型电池)以便给眼压监测器1供电。另外，在另一些示例中，也可以通过与眼压监测器1耦接的外部设备来供电，例如体外电源通过无线传输的方式传递给眼压监测器1。In some examples, a battery (microbattery) may be provided within the tonometer 1 to power the tonometer 1 . In addition, in some other examples, power may also be provided by an external device coupled to the intraocular pressure monitor 1 , for example, external power is transmitted to the intraocular pressure monitor 1 through wireless transmission.
在一些示例中，眼内压力可以通过眼压监测器1经常地进行测量。例如，可以使用与眼压监测器1耦接的手持式读取器(未图示)来进行测量。作为示例，该手持式读取器可以具有发射能量的部件、以及接收从眼压监测器1发射出来的压力信号的接收线圈(未图示)。通过该手持式读取器，既可以给眼压监测器1供电，也可以接收由眼压监测器1测量的压力信号。In some examples, intraocular pressure may be measured frequently by the tonometry monitor 1 . For example, measurements may be taken using a hand-held reader (not shown) coupled to the tonometer 1 . As an example, the handheld reader may have an energy emitting component, and a receiving coil (not shown) that receives the pressure signal emitted from the tonometer 1 . Through the hand-held reader, the tonometry monitor 1 can be supplied with power, and the pressure signal measured by the tonometry monitor 1 can also be received.
在本实施方式中，眼内压力的测量可以以间断的方式监测(非连续监测)，也可以以连续(例如足够的频度)的方式监测(连续监测)。通过手持式读取器读取眼压监测器1的压力数据，可以确定每日的眼压曲线，从而探测眼压峰值和压力峰值。手持式读取可以自动地将所获得的病人眼压信息传送给主治医生，从而帮助医生远距离监控病人的眼压情况。In this embodiment, the measurement of the intraocular pressure may be monitored intermittently (discontinuous monitoring) or continuously (for example, with sufficient frequency) (continuous monitoring). By reading the pressure data of the intraocular pressure monitor 1 with a hand-held reader, the daily intraocular pressure curve can be determined, thereby detecting intraocular pressure peaks and pressure peaks. The hand-held reading can automatically transmit the obtained patient's intraocular pressure information to the attending doctor, thereby helping the doctor to remotely monitor the patient's intraocular pressure.
通过眼压监测器1所获得的直接眼压测量数据有许多益处。例如，眼压测量数据可以对病人触发警报，并且将该数据发送到远程的服务器或病人主治医生的办公室。另外，发送到远程服务器的数据可以进行分析，例如进行数据挖掘以确定统计学的趋势和分析。由此，借助这些数据，医生便可以及时地监控病人病情，以让病人能够得到及时和有效的治疗。Direct tonometric data obtained by tonometer 1 has many benefits. For example, tonometry data can trigger an alert to the patient, and the data can be sent to a remote server or to the office of the patient's attending physician. In addition, the data sent to the remote server may be analyzed, such as data mining to determine statistical trends and analysis. Therefore, with the help of these data, doctors can monitor the patient's condition in time, so that the patient can receive timely and effective treatment.
再次参见图3，眼睛包括巩膜和晶状体，晶状体使光线折射而在眼睛的视网膜形成图像。视网膜包括视锥细胞和视杆细胞，能够探测光颜色敏感度和高视觉灵敏度。视网膜还包括盲点，视神经在此汇集并连接到大脑。虹膜位于晶状体上方，其在黑暗中响应于光线而扩张却在明亮光线中收缩，这样射到视网膜上的光线强度可分别增强和减弱。眼睛包括前部和后部，晶状体就设置在两者之间。前部包括水状体，后部包括玻璃体。眼睛的后腔室延伸在虹膜和晶状体的前包膜之间，并包括水状体。前部包括该后房。眼睛的液体通常从后房排放到前房，并排出到施累姆氏管之外以保持眼内压力。Referring again to Figure 3, the eye includes the sclera and the lens which refracts light to form an image on the retina of the eye. The retina consists of cone and rod cells that detect light color sensitivity and high visual acuity. The retina also includes the blind spot, where the optic nerves converge and connect to the brain. The iris, which sits above the lens, expands in response to light in the dark and contracts in bright light, so that the intensity of the light hitting the retina increases and decreases, respectively. The eye consists of a front and a back, with the lens located between the two. The anterior part contains the aqueous humor and the posterior part contains the vitreous humor. The posterior chamber of the eye extends between the iris and the anterior capsule of the lens and contains the aqueous humor. The front includes this rear room. Fluid from the eye normally drains from the posterior to the anterior chamber and out of Schlemm's canal to maintain intraocular pressure.
眼压监测器1的测量端(即包含形变膜的端部)可以植入到眼睛的前房，使眼压监测器1的前端与眼睛内的组织液直接接触，从而眼压监测器1能够直接测量眼睛的眼内压力。The measuring end of the intraocular pressure monitor 1 (that is, the end containing the deformable membrane) can be implanted into the anterior chamber of the eye, so that the front end of the intraocular pressure monitor 1 is in direct contact with the interstitial fluid in the eye, so that the intraocular pressure monitor 1 can directly Measures the intraocular pressure of the eye.
在本实施方式中，眼压监测器1的尺寸没有特别限制，例如眼压监测器1的长度可达2～15mm。另外，从目前手术安全的观点看，其最宽处的宽度约为5mm，在这种情况下，能够降低术后的并发症。In this embodiment, the size of the intraocular pressure monitor 1 is not particularly limited, for example, the length of the intraocular pressure monitor 1 can reach 2-15 mm. In addition, from the point of view of current surgical safety, the width at its widest point is about 5 mm, and in this case, postoperative complications can be reduced.
图4是示出了本发明的实施方式所涉及的植入式眼压监测器的密封腔体与支撑部分离的结构图。图5是示出了图1所示的植入式眼压监测器的内部结构示意图。Fig. 4 is a structural view showing the separation of the sealed cavity and the supporting part of the implantable intraocular pressure monitor according to the embodiment of the present invention. FIG. 5 is a schematic diagram showing the internal structure of the implantable intraocular pressure monitor shown in FIG. 1 .
在本实施方式中，如图4所示，密封腔体10的端部可以具有跟随压力强度变化而产生形变的形变膜14。在一些示例中，密封腔体10的端部可以是前端，即，与眼内组织液接触的一端。In this embodiment, as shown in FIG. 4 , the end of the sealed cavity 10 may have a deformable film 14 that deforms following changes in pressure intensity. In some examples, the end of the sealed cavity 10 may be the front end, ie, the end that is in contact with intraocular tissue fluid.
另外，在一些示例中，形变膜14可以为弹性膜。在眼压监测器1植入到规定位置后，位于密封腔体10前端的形变膜14将与眼睛内部的组织液直接接触，由于形变膜14可以跟随眼内压力强度变化而产生形变，因此，通过形变膜14，能够获得眼内组织液的压力强度。Additionally, in some examples, deformable membrane 14 may be an elastic membrane. After the intraocular pressure monitor 1 is implanted at the specified position, the deformable membrane 14 located at the front end of the sealed cavity 10 will directly contact the interstitial fluid inside the eye. Since the deformable membrane 14 can deform according to the change of intraocular pressure intensity, therefore, by The deformable membrane 14 can obtain the pressure strength of intraocular tissue fluid.
在本实施方式中，密封腔体10可以呈大致圆筒状。另外，密封腔体10可以由侧壁12、形变膜14、以及馈通结构16形成。另外，尽管本实施方式示出密封腔体10为大致圆筒状，但密封腔体10也可以是其他形状，例如长方体或不规则形状等。In this embodiment, the sealed cavity 10 may be substantially cylindrical. In addition, the sealed cavity 10 may be formed by the sidewall 12 , the deformable membrane 14 , and the feedthrough structure 16 . In addition, although the present embodiment shows that the sealed cavity 10 is substantially cylindrical, the sealed cavity 10 may also be in other shapes, such as a rectangular parallelepiped or an irregular shape.
在本实施方式中，侧壁12可以形成为大致环状结构。侧壁12的厚度(即环壁的厚度)没有特别限制，例如在一些示例中，侧壁12的环壁厚度约为0.3mm以上便能够达到良好的支撑强度，例如，侧壁12的环壁厚度优选为0.3mm～1mm。In this embodiment, the side wall 12 may be formed in a substantially ring-shaped structure. The thickness of the side wall 12 (that is, the thickness of the ring wall) is not particularly limited. For example, in some examples, the thickness of the ring wall of the side wall 12 is about 0.3mm or more to achieve good support strength. For example, the ring wall of the side wall 12 The thickness is preferably 0.3 mm to 1 mm.
另外，在本实施方式中，形变膜14可以设置在侧壁12的端部，馈通结构16设置在侧壁12的另一端。另外，例如可以通过焊接的方式将形变膜14、侧壁12和馈通结构16焊接在一起。这里，焊接的方式可以采用本领域技术人员公知的技术例如激光焊接，因此，在本说明书中将不再赘述。In addition, in this embodiment, the deformable membrane 14 may be disposed at one end of the side wall 12 , and the feedthrough structure 16 may be disposed at the other end of the side wall 12 . In addition, for example, the deformable membrane 14 , the side wall 12 and the feedthrough structure 16 can be welded together by welding. Here, the way of welding may adopt techniques known to those skilled in the art, such as laser welding, so details will not be repeated in this specification.
在本实施方式中，侧壁12可以由选自钛及其合金、贵金属(包括金、银和铂族金属(钌、铑、钯、锇、铱、铂))及其合金、医用级(biograde)不锈钢、钽、铌、镍钛诺(Nitinol)、或镍钴铬钼合金(MP35N)中的至少一种构成。另外，侧壁12优选可以由钛或者钛合金材料构成。In this embodiment, the sidewall 12 can be selected from titanium and its alloys, noble metals (including gold, silver and platinum group metals (ruthenium, rhodium, palladium, osmium, iridium, platinum)) and their alloys, medical grade (biograde) ) stainless steel, tantalum, niobium, Nitinol (Nitinol), or nickel-cobalt-chromium-molybdenum alloy (MP35N). In addition, the side wall 12 can preferably be made of titanium or a titanium alloy material.
参考图5，馈通结构16可以由陶瓷基底16c和填充于馈通孔16a和馈通孔16b的金属柱构成。在这种情况下，可以实现陶瓷基底16c两侧经由填充于馈通孔16a和馈通孔16b的金属柱而导电。Referring to FIG. 5 , the feedthrough structure 16 may be composed of a ceramic substrate 16c and metal pillars filled in the feedthrough holes 16a and 16b. In this case, the two sides of the ceramic substrate 16c can be electrically conductive through the metal pillars filled in the feedthrough hole 16a and the feedthrough hole 16b.
另外，为了便于与处理电路200(稍后描述)的电连接，也可以在陶瓷基底16c上进行金属图案化。在陶瓷基底16c上的金属图案化的步骤可以包括金属沉积(deposition)或溅射(sputtering)、光刻(lithography)、刻蚀(etching)等常规工艺步骤，由于这些常规工艺步骤均属于公知技术，因此这里不再赘述。另外，在陶瓷基底11上的金属图案化也可以采用公知的丝网印刷工艺。In addition, metal patterning may also be performed on the ceramic substrate 16c in order to facilitate electrical connection with a processing circuit 200 (described later). The steps of metal patterning on the ceramic substrate 16c may include metal deposition (deposition) or sputtering (sputtering), photolithography (lithography), etching (etching) and other conventional process steps, because these conventional process steps belong to the known technology , so it will not be repeated here. In addition, the metal patterning on the ceramic substrate 11 can also use a known screen printing process.
如图4所示，馈通孔16a、16b内填充有金属柱。金属柱的形状可以分别与馈通孔16a、16b配合。通过设置馈通结构16，从而既能够确保密封腔体10的高气密性，又能够保证馈通结构16两侧的导电。As shown in FIG. 4, the feedthrough holes 16a, 16b are filled with metal pillars. The shape of the metal pillars can match the feedthrough holes 16a, 16b respectively. By providing the feedthrough structure 16 , it is possible to ensure high airtightness of the sealed cavity 10 and to ensure electrical conduction on both sides of the feedthrough structure 16 .
此外，在密封腔体10内，设置有压力传感器100和处理电路200。由于密封腔体10需要作为植入体长期保留在眼睛内，因此密封腔体10的侧壁12、形变膜14以及馈通结构16各部分需要与眼睛内的组织液直接接触，面临体内的复杂生理环境。因此，密封腔体10的生物安全性、长期植入可靠性等需要满足相关的要求例如ISO 10993(国际标准)、GB/T 16886(中国标准)等。In addition, in the sealed cavity 10, a pressure sensor 100 and a processing circuit 200 are arranged. Since the sealed cavity 10 needs to be kept in the eye as an implant for a long time, the side wall 12, the deformable membrane 14 and the feedthrough structure 16 of the sealed cavity 10 need to be in direct contact with the interstitial fluid in the eye, facing complex physiological conditions in the body. surroundings. Therefore, the biological safety and long-term implantation reliability of the sealed cavity 10 need to meet relevant requirements such as ISO 10993 (international standard), GB/T 16886 (Chinese standard) and the like.
一般而言，为了确保眼压监测器1的生物安全性、长期植入可靠性等，密封腔体10一方面将眼压监测器1内的非生物安全性部件例如IC芯片、印刷电路板(PCB)等与被植入部位(例如组织液)隔离；另一方面，通过馈通结构16的馈通孔16a、16b从该密封腔体10引出信号交互的功能导线。也即，密封腔体10的线路经由馈通结构16的馈通孔16a、16b引出到信号传输装置(这里是线圈300)(参见图6)。Generally speaking, in order to ensure the biological safety and long-term implantation reliability of the intraocular pressure monitor 1, the sealed cavity 10 seals the non-biosafety components in the intraocular pressure monitor 1 such as IC chips, printed circuit boards ( PCB) and the like are isolated from the implanted site (such as interstitial fluid); That is, the lines of the sealed cavity 10 are led out to the signal transmission device (here, the coil 300 ) through the feedthrough holes 16 a, 16 b of the feedthrough structure 16 (see FIG. 6 ).
如图3和图4所示，支撑部20与密封腔体10联接。支撑部20可以包括基部22和从基部22伸出的突起部24。另外，基部22例如可以呈圆盘状，突起部24呈大致圆柱状。另外，突起部24可以在相对的两侧沿着植入方向布置的凸起24a、24b(参考图4)。在这种情况下，由于在突起部24的两侧设置有凸起24a和凸起24b，因此能够更容易使眼球表面的切口(巩膜切口)例如自然地水密，由此更有利于手术口的缝合。As shown in FIGS. 3 and 4 , the support part 20 is coupled with the sealed cavity 10 . The support part 20 may include a base part 22 and a protrusion part 24 extending from the base part 22 . In addition, the base portion 22 may have a disc shape, for example, and the protrusion portion 24 may have a substantially cylindrical shape. In addition, the protrusion 24 may be protrusions 24a, 24b arranged on opposite sides along the implantation direction (refer to FIG. 4 ). In this case, since the protrusion 24a and the protrusion 24b are provided on both sides of the protrusion 24, it is easier to make the incision (sclera incision) on the surface of the eyeball, for example, naturally watertight, thereby facilitating the opening of the operation port. suture.
此外，基部22内可以设置有信号传输装置。在本实施方式中，信号传输装置可以是线圈300(参见图5)。线圈300可以经由馈通结构16(具体是经由馈通孔16a、16b)与处理电路200连接。In addition, a signal transmission device may be provided in the base part 22 . In this embodiment, the signal transmission device may be a coil 300 (see FIG. 5 ). The coil 300 may be connected with the processing circuit 200 via the feedthrough structure 16 (in particular via the feedthrough holes 16a, 16b).
另外，图6是本发明的实施方式所涉及的植入式眼压监测器的线圈300的示意图。如图6所示，线圈300作为接收天线可以接收从外部输入的能量，也可以从设置在眼压监测器1内部的电池(未图示)来获取能量。线圈300作为发射天线将来自压力传感器100的压力信号传输到外部。换言之，来自压力传感器100的压力信号经由密封腔体10(具体是密封腔体的馈通结构16)而传输到支撑部20的线圈300。这里，馈通结构16的馈通孔16a、16b与线圈的连接线420、440电连接。通过线圈300，能够有效地将眼内的压力信号传输到眼外，同时将眼外的能量传输给眼内的眼压监测器1，由此能够实现方便的眼内压力的监测。In addition, FIG. 6 is a schematic diagram of the coil 300 of the implantable intraocular pressure monitor according to the embodiment of the present invention. As shown in FIG. 6 , the coil 300 as a receiving antenna can receive energy input from the outside, and can also obtain energy from a battery (not shown) provided inside the intraocular pressure monitor 1 . The coil 300 transmits the pressure signal from the pressure sensor 100 to the outside as a transmitting antenna. In other words, the pressure signal from the pressure sensor 100 is transmitted to the coil 300 of the support part 20 via the sealed cavity 10 (specifically, the feedthrough structure 16 of the sealed cavity). Here, the feedthrough holes 16a, 16b of the feedthrough structure 16 are electrically connected to the connecting wires 420, 440 of the coil. Through the coil 300, the intraocular pressure signal can be effectively transmitted to the outside of the eye, and at the same time, the energy outside the eye can be transmitted to the intraocular pressure monitor 1, thereby enabling convenient monitoring of the intraocular pressure.
在本实施方式中，压力传感器100可以经由处理电路200、线圈300而耦接到外部读取器(未图示)。这里，外部读取器可以根据直接测得的眼内压力和外部大气压力来确定病人的眼压。由于大气压力可在大约±10mmHg范围内波动，并且还会随着病人的海拔高度而变，因而根据由眼压监测器1所获得的眼压、以及眼睛外部的大气压力来确定所获得的最终眼压，由此，可以显著提高报告给医生和病人的眼压的精确度。In this embodiment, the pressure sensor 100 can be coupled to an external reader (not shown) via the processing circuit 200 and the coil 300 . Here, an external reader can determine the patient's intraocular pressure based on direct measurements of intraocular pressure and external atmospheric pressure. Since the atmospheric pressure can fluctuate in the range of approximately ±10mmHg and also varies with the altitude of the patient, the final obtained final pressure is determined based on the intraocular pressure obtained by the tonometer 1 and the atmospheric pressure outside the eye. Intraocular pressure, thereby, can significantly improve the accuracy of intraocular pressure reported to doctors and patients.
外部读取器例如可以根据直接测得的眼压和大气压力来确定病人的眼压。例如，外部读取器可以包括大气压力传感器，以便根据压力传感器100直接测得的眼压和当地的大气压力来确定报告给医生和病人的眼压。可选地，外部读取器也可以包括确定病人地理位置的专用电路，并且可以根据气象的天气信息，使用病人位置信息来确定病人所处位置的压力。病人的地理位置坐标可以由与外部读取器的移动电话或者全球定位系统(GPS)电路进行定位。An external reader can determine the patient's intraocular pressure, for example, from directly measured intraocular pressure and atmospheric pressure. For example, an external reader may include an atmospheric pressure sensor to determine the reported intraocular pressure to physicians and patients based on the intraocular pressure measured directly by pressure sensor 100 and the local atmospheric pressure. Optionally, the external reader may also include dedicated circuitry to determine the geographic location of the patient, and the patient location information may be used to determine the pressure at the patient's location, based on meteorological weather information. The patient's geographic coordinates can be located by a mobile phone with an external reader or a Global Positioning System (GPS) circuit.
众所周知，大气压力会随着天气变化而缓慢波动，并在大约±10mmHg的量级上。在这种情况下，可以在数据处理阶段根据气象信息来对测得的病人眼压所作的纠正，提供精确更高的眼压值。另外，通过确定病人的位置，便可以确定与病人所在海拔相关的大气压力的波动，并用来确定病人的眼压。例如，从直接测得的眼压中减去病人所在位置和海拔的大气压力，以确定报告给医生和病人的纠正过的眼压，由此可确定报告给医生和病人的眼压。It is well known that atmospheric pressure fluctuates slowly with weather and is on the order of about ±10mmHg. In this case, the measured intraocular pressure of the patient can be corrected according to the meteorological information in the data processing stage to provide a more accurate and higher intraocular pressure value. Additionally, by determining the patient's location, fluctuations in atmospheric pressure relative to the patient's altitude can be determined and used to determine the patient's intraocular pressure. For example, the corrected intraocular pressure reported to the physician and patient can be determined by subtracting the atmospheric pressure at the patient's location and altitude from the directly measured intraocular pressure.
图7是示出了本发明的实施方式所涉及的植入式眼压监测器中的压力传感器的示意图。压力传感器100设置在密封腔体10内并且靠近形变膜，压力传感器100通过检测形变膜的形变变化来获得压力信号。压力传感器100与形变膜14之间形成内部腔体16。Fig. 7 is a schematic diagram showing a pressure sensor in the implantable tonometry monitor according to the embodiment of the present invention. The pressure sensor 100 is arranged in the sealed cavity 10 and close to the deformable membrane, and the pressure sensor 100 obtains a pressure signal by detecting the deformation change of the deformable membrane. An internal cavity 16 is formed between the pressure sensor 100 and the deformable membrane 14 .
在本实施方式中，压力传感器100可以使用带有光栅的压力传感器。具体而言，压力传感器100包括基底110、光栅120、以及设置在基底110与光栅120之间的激光器150和光电探测器130。激光器150相对于基底110以一定的角度射出激光L。光栅120为半透明的光栅结构，其材料没有特别限制。由此，入射到光栅120的激光将有一部分透过光栅120，有一部分激光被光栅120反射。In this embodiment, the pressure sensor 100 may use a pressure sensor with a grating. Specifically, the pressure sensor 100 includes a substrate 110 , a grating 120 , and a laser 150 and a photodetector 130 disposed between the substrate 110 and the grating 120 . The laser 150 emits laser light L at a certain angle relative to the substrate 110 . The grating 120 is a translucent grating structure, and its material is not particularly limited. Therefore, part of the laser light incident on the grating 120 will pass through the grating 120 , and part of the laser light will be reflected by the grating 120 .
如图7所示，在一些示例中，由激光器150发射的激光L沿着图示箭头的方向行进。激光L遇到光栅120后发生衍射和透射，有一部分激光L被光栅120反射，有一部分激光L直接透过光栅120。并且通过反射而被光电探测器130捕获。透过光栅120的激光被形变膜14反射回来。这两部分反射的激光将发生干涉，干涉光的光强分布被光电探测器130所检测。由于形变膜14能够跟随眼内压力强度变化而产生形变，因此，在上述光衍射和干涉过程中，两部分激光所形成的干涉条纹将会变化。由于不同的干涉条纹对应不同的光强分布，光电探测器130所探测到的光强也不同。由此，通过分析眼压与光强度的关系，由此能够得到眼压的压力强度。As shown in FIG. 7 , in some examples, the laser light L emitted by the laser 150 travels in the direction of the arrow shown in the figure. The laser light L is diffracted and transmitted after encountering the grating 120 , part of the laser light L is reflected by the grating 120 , and part of the laser light L directly passes through the grating 120 . And captured by the photodetector 130 by reflection. The laser light passing through the grating 120 is reflected back by the deformable membrane 14 . The reflected laser light from these two parts will interfere, and the light intensity distribution of the interference light is detected by the photodetector 130 . Since the deformable membrane 14 can deform according to changes in intraocular pressure intensity, the interference fringes formed by the two laser beams will change during the above-mentioned light diffraction and interference process. Since different interference fringes correspond to different light intensity distributions, the light intensities detected by the photodetector 130 are also different. Thus, by analyzing the relationship between the intraocular pressure and the light intensity, the pressure intensity of the intraocular pressure can be obtained.
在本实施方式中，激光器150的能量可以由设置在眼压监测器1内的电池提供，也可以通过线圈300从外部获取能量。激光器150可以使用例如垂直腔表面发射激光器。这种激光器能够发射出垂直于激光器的表面的激光，因此，使用垂直腔表面发射激光器，能够容易地控制激光的射出方向。这里，光电探测器130可以设置多个，例如两个。In this embodiment, the energy of the laser 150 can be provided by a battery provided in the intraocular pressure monitor 1 , or can be obtained from the outside through the coil 300 . The laser 150 may use, for example, a vertical cavity surface emitting laser. Such a laser can emit laser light perpendicular to the surface of the laser, and therefore, the emission direction of the laser light can be easily controlled by using a vertical cavity surface emitting laser. Here, multiple photodetectors 130 may be provided, for example two.
在本实施方式中，突起部24可以与密封腔体10固定联接(参见图5)。另外，通过突起部24，能够方便定位密封腔体10的形变膜14的朝向。In this embodiment, the protrusion 24 can be fixedly coupled with the sealed cavity 10 (see FIG. 5 ). In addition, the orientation of the deformable membrane 14 of the sealed cavity 10 can be conveniently positioned through the protruding portion 24 .
此外，在本实施方式中，处理电路200可以驱动压力传感器100，并且对由压力传感器100获得的压力信号进行处理。处理电路200可以通过在印刷电路板(PCB)上制作包括例如电阻器、电容器或电感器等分立元器件或者集成电路芯片(IC)例如专用集成电路(ASIC)、可编程逻辑电路(FPGA)、电可擦除只读存储器(EEPROM)等而构成。另外，处理电路200也可以是其他功能部件，只要能够满足特定植入运用要求的功能即可。另外，处理电路200可以由PCB层叠而成。由此，可以有效地缩小处理电路200的占有面积。In addition, in this embodiment, the processing circuit 200 can drive the pressure sensor 100 and process the pressure signal obtained by the pressure sensor 100 . The processing circuit 200 can be fabricated on a printed circuit board (PCB), including discrete components such as resistors, capacitors, or inductors, or integrated circuit chips (ICs) such as application-specific integrated circuits (ASICs), programmable logic circuits (FPGAs), Electrically Erasable Read Only Memory (EEPROM) etc. In addition, the processing circuit 200 may also be other functional components, as long as it can meet the requirements of specific implant applications. In addition, the processing circuit 200 may be formed by stacking PCBs. Accordingly, the occupied area of the processing circuit 200 can be effectively reduced.
在本实施方式中，处理电路200例如可以起到对输入信号、刺激信号或检测信号等各种信号进行信号处理的作用。In this embodiment, the processing circuit 200 can perform signal processing on various signals such as input signals, stimulation signals, or detection signals, for example.
另外，为了改善眼压监测器1的测量精度，也可以使内部腔体16通过延伸至支撑部20的管道(未图示)与外部空气连通。由于内部腔体16通过管道与外部空气连接，因此，能够减小外部空气压力变化而导致的测量误差，提高眼压监测器1的测量精度。In addition, in order to improve the measurement accuracy of the intraocular pressure monitor 1 , the internal cavity 16 may also communicate with the outside air through a pipe (not shown) extending to the support part 20 . Since the internal cavity 16 is connected to the external air through the pipe, the measurement error caused by the change of the external air pressure can be reduced, and the measurement accuracy of the intraocular pressure monitor 1 can be improved.
本实施方式所涉及的压力传感器100可以通过微机电系统(MEMS)的方法来进行制造。例如，压力传感器100可以包括用基底(诸如玻璃基底)支承的单片传感器。可选地，压力传感器100也可以包括混合型传感器，其具有支承在诸如柔性印刷电路板(PCB)的柔性基底上的微机电系统压力传感器，例如是聚酰亚胺柔性印刷电路板。The pressure sensor 100 according to this embodiment can be manufactured by a microelectromechanical system (MEMS) method. For example, pressure sensor 100 may comprise a monolithic sensor supported by a substrate, such as a glass substrate. Alternatively, the pressure sensor 100 may also comprise a hybrid sensor having a MEMS pressure sensor supported on a flexible substrate such as a flexible printed circuit board (PCB), for example a polyimide flexible printed circuit board.
眼压监测器1植入眼镜内的方法并没有特别限制。例如，可以将封装好的眼压监测器1放置到套管内，并通过递送工具将眼压监测器1送入到植入部位例如前房靠近施累姆氏管的位置。The method of implanting the intraocular pressure monitor 1 into the glasses is not particularly limited. For example, the packaged intraocular pressure monitor 1 can be placed in a cannula, and the intraocular pressure monitor 1 can be delivered to the implantation site such as the anterior chamber near Schlemm's canal through a delivery tool.
在一些示例中，在支撑部20中，还设置有用于手术器械操作的安装孔22a。例如，通过眼科手术用的递送工具与该安装孔22a嵌合，从而能够通过递送工具将眼压监测器1植入到规定部位例如前房。递送工具尺寸适于接纳眼压监测器1。In some examples, a mounting hole 22a for operation of surgical instruments is also provided in the support portion 20 . For example, by fitting a delivery tool for ophthalmic surgery into the attachment hole 22a, the intraocular pressure monitor 1 can be implanted in a predetermined site such as the anterior chamber using the delivery tool. The delivery tool is sized to receive the tonometer 1 .
虽然以上结合附图和实施方式对本发明进行了具体说明，但是其并不是为了限制本发明，应当理解，对于本领域技术人员而言，在不偏离本发明的实质和范围的情况下，可以对本发明进行变形和改变，这些变形和改变均落入本发明的权利要求所保护的范围内。Although the present invention has been specifically described above in conjunction with the accompanying drawings and embodiments, it is not intended to limit the present invention. It should be understood that for those skilled in the art, without departing from the essence and scope of the present invention, the The invention carries out deformations and changes, and these deformations and changes all fall within the scope protected by the claims of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811315131.3ACN109157190B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor with protrusion |
| CN201811315050.3ACN109157189B (en) | 2016-05-27 | 2017-05-27 | Implantable pressure monitor |
| Application Number | Priority Date | Filing Date | Title |
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| CN2016103625899 | 2016-05-27 | ||
| CN201610362589 | 2016-05-27 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811315131.3ADivisionCN109157190B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor with protrusion |
| CN201811315050.3ADivisionCN109157189B (en) | 2016-05-27 | 2017-05-27 | Implantable pressure monitor |
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| CN107432733A CN107432733A (en) | 2017-12-05 |
| CN107432733Btrue CN107432733B (en) | 2019-08-20 |
| Application Number | Title | Priority Date | Filing Date |
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| CN201710393827.7AActiveCN107432733B (en) | 2016-05-27 | 2017-05-27 | Implantable Tonometry Monitor |
| CN201811315050.3AActiveCN109157189B (en) | 2016-05-27 | 2017-05-27 | Implantable pressure monitor |
| CN201811315131.3AActiveCN109157190B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor with protrusion |
| Application Number | Title | Priority Date | Filing Date |
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| CN201811315050.3AActiveCN109157189B (en) | 2016-05-27 | 2017-05-27 | Implantable pressure monitor |
| CN201811315131.3AActiveCN109157190B (en) | 2016-05-27 | 2017-05-27 | Implanted intraocular pressure monitor with protrusion |
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