CN107126290B - An artificial optic nerve cannula for experimental animals - Google Patents

Abstract

Translated fromChinese

本发明提供一种实验动物用人工视神经套管，以无毒环保的聚甲基丙烯酸甲酯为制作材料，包括上半空心圆柱体和下半空心圆柱体，上半空心圆柱体和下半空心圆柱体的一侧通过连接部连接在一起，下半空心圆柱体中心有半球形突起，上半空心圆柱体设有上延展部，上延展部上设有两个方孔，下半空心圆柱体设有下延展部，下延展部上设有两个扣子，将其套在视神经上将扣子扣上，半球形突起可对视神经局部进行长期压迫状态，通过选择不同半球形凸起可以对压迫程度进行控制可定量损伤视神经。

The invention provides an artificial optic nerve cannula for experimental animals, which is made of non-toxic and environmentally friendly polymethyl methacrylate, including an upper half-hollow cylinder and a lower half-hollow cylinder, an upper half-hollow cylinder and a lower half-hollow cylinder. One side of the cylinder is connected together by a connecting part, the center of the lower half hollow cylinder has a hemispherical protrusion, the upper half hollow cylinder is provided with an upper extension part, and two square holes are arranged on the upper extension part, and the lower half hollow cylinder is provided with an upper extension part. There is a lower extension part, and two buttons are arranged on the lower extension part. Put them on the optic nerve and fasten the buttons. The hemispherical protrusion can compress the optic nerve for a long time. Controlling quantifies damage to the optic nerve.

Description

Artificial optic nerve casing for experimental animal

Technical Field

The invention belongs to a medical model tool, and particularly relates to an artificial optic nerve casing for animal experiments.

Background

Indirect Traumatic Optic Neuropathy (ITON) is a serious damage to optic nerve function caused by sudden external blunt force striking on the frontotemporal part above the orbital-eyebrow arch, and most patients show acute visual deterioration after injury, even complete loss. According to statistics, the ITON accounts for about 5% of closed craniocerebral injury, and along with rapid development of industrial and mining industry, traffic industry, tourism industry and the like, the incidence rate of ITON is increasing in China, and the ITON becomes common serious eye trauma.

The pathogenesis of ITON comprises three aspects, namely, instant external force indirectly acts on optic nerves to cause nerve injury, fractured optic nerve sleeve impacts and generates long-term compression on the optic nerves, and the intact part of the optic nerve sleeve forms constraint on the optic nerves of inflammatory edema to further cause high pressure in the tube. For better treatment of the disease, there is an urgent need for a quantitative/analyzable animal model that is consistent with the pathogenesis of the disease, and includes a number of aspects: firstly, manufacturing extrusion pressure to act on optic nerve; secondly, the pressure can be quantized/graded; and thirdly, the intraductal high pressure state of the local optic nerve can be simulated.

In order to cause pressure to optic nerves, the patent application No. CN200820155530.3 provides an automatic quantitative injury device for peripheral nerves of experimental animals, the motor control is adopted, the optic nerve sleeve is accurately pressurized, the method is accurate and quantitative, but only temporarily causes damage to the optic nerves, and the high-pressure state in a long-term optic nerve pipe after ITON cannot be simulated; the article on page 283-: the morphological research of optic nerve injury on retinal structure provides an optic nerve impact animal model, the optic nerve of the apical part of the orbit of a guinea pig is exposed in the cranium by operation, a blunt round head wood strip is vertically arranged above the optic nerve, a weight is completely vertically and freely dropped from a high position to impact the wood strip, so that the indirect impact injury of the optic nerve intraorbital section in the cranium is caused. Therefore, the current technology can not completely meet the three conditions, and a model which can simultaneously meet the requirements of manufacturing the extrusion pressure acting on the optic nerve, quantifying/grading the pressure and simulating the intraductal high-pressure state of the local optic nerve needs to be designed for research.

Disclosure of Invention

The invention provides an artificial optic nerve casing for experimental animals, which comprises an upper half hollow cylinder and a lower half hollow cylinder, wherein one sides of the upper half hollow cylinder and one side of the lower half hollow cylinder are connected together through a connecting part, a hemispherical bulge is arranged in the center of the lower half hollow cylinder, the upper half hollow cylinder is provided with an upper extension part, two square holes are arranged on the upper extension part, the lower half hollow cylinder is provided with a lower extension part, and two buttons are arranged on the lower extension part.

Specifically, the inner diameters of the upper half hollow cylinder and the lower half hollow cylinder are the same and are 0.1-3 mm.

Specifically, the diameters of the hemispherical bulges are set in a gradient manner to different sizes.

Specifically, the artificial optic nerve casing is made of polymethyl methacrylate.

The invention has the advantages that: the optic nerve compression sleeve is sleeved on an optic nerve, the hemispherical protrusions can compress the optic nerve locally for a long time, the compression degree can be controlled by selecting different hemispherical protrusions, the optic nerve can be quantitatively damaged, and the optic nerve compression sleeve can be detached after a period of time to simulate optic nerve decompression operation.

Drawings

FIG. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a front view of the present invention.

Fig. 3 is a closed state diagram of the present invention.

Fig. 4 is a closed state diagram of the present invention.

Fig. 5 is a schematic diagram of the present invention.

Detailed Description

The artificial optic nerve casing for the experimental animal provided by the embodiment is made of non-toxic environment-friendly polymethyl methacrylate, and has a structure shown in fig. 1-4, and comprises an upper halfhollow cylinder 100 and a lower halfhollow cylinder 200, wherein the inner diameters of the upper halfhollow cylinder 100 and the lower halfhollow cylinder 200 are the same, and because the thicknesses of optic nerves of different experimental animals are different, the inner diameters of different hollow cylinders are set to be different sizes between 0.1 mm and 3mm for matching experiments on different optic nerves; firsthollow cylinder 100 links together through connectingportion 300 with one side of secondhollow cylinder 200, the opposite side of firsthollow cylinder 100 is equipped withextension portion 110, be equipped with twosquare holes 111 on theextension portion 110, the opposite side of secondhollow cylinder 200 is equipped withextension portion 210 down, be equipped with twobuckles 211 on theextension portion 110 down, passsquare hole 111 with firsthollow cylinder 100 and secondhollow cylinder 200 withbuckle 211 and link together and form hollow cylinder, secondhollow cylinder 200 center hashemisphere arch 400, and the size of different diameters is different to the oppression dynamics of nerve, consequently is the gradient withhemisphere arch 400's diameter and sets up different sizes into.

When the artificial optic nerve sleeve is used, as shown in fig. 5, the artificial optic nerve sleeve with the matched inner diameter is selected to be sleeved on an optic nerve, thebutton 211 penetrates through thesquare hole 111 to be fastened, thehemispherical bulge 400 at the center of thesemi-hollow cylinder 200 can locally extrude the optic nerve to generate constant pressure, and if the artificial optic nerve sleeve is not taken down, the pressure exists all the time, so that the effect of extruding the optic nerve by the bone flap of the optic nerve sleeve for a long time can be simulated.

Thehemispherical bulge 400 of different artificial optic nerve sleeves is that the gradient sets up to different diameters size and forms multiple specifications, and thehemispherical bulge 400 of different specifications is different to the oppression power of optic nerve, can come control oppression degree through the size of selectinghemispherical bulge 400, can quantitatively damage optic nerve, pull down the effect that can simulate optic nerve decompression operation after a period of time with it.

The above embodiments are only for the purpose of illustrating the present invention in detail, and are not to be construed as limiting the invention, and other persons in the art may make any changes and substitutions to the technical solution of the present invention without inventive efforts, and all fall within the protection scope of the present invention.

Claims (3)

Translated fromChinese

1.一种实验动物用人工视神经套管，其特征在于：其包括上半空心圆柱体(100)和下半空心圆柱体(200)，所述上半空心圆柱体(100)和下半空心圆柱体(200)的一侧通过连接部(300)连接在一起，所述下半空心圆柱体(200)中心有半球形凸起(400)，所述上半空心圆柱体(100)的另一侧设有上延展部(110)，所述上延展部(110)上设有两个方孔(111)，所述下半空心圆柱体(200)的另一侧设有下延展部(210)，所述下延展部(210)上设有两个扣子(211)；所述半球形凸起(400)的直径呈梯度设置成不同大小，将所述扣子(211)穿过所述方孔(111)将所述上半空心圆柱体(100)和所述下半空心圆柱体(200)连接在一起形成空心圆柱体。1. an artificial optic nerve cannula for experimental animals, characterized in that: it comprises an upper half-hollow cylinder (100) and a lower half-hollow cylinder (200), the upper half-hollow cylinder (100) and the lower half-hollow cylinder (100) One side of the cylinder (200) is connected together by a connecting portion (300), the center of the lower semi-hollow cylinder (200) has a hemispherical protrusion (400), and the other side of the upper semi-hollow cylinder (100) is provided. One side is provided with an upper extension portion (110), the upper extension portion (110) is provided with two square holes (111), and the other side of the lower semi-hollow cylinder (200) is provided with a lower extension portion (111). 210), two buttons (211) are provided on the lower extension part (210); the diameters of the hemispherical protrusions (400) are set to different sizes in a gradient, and the buttons (211) are passed through the A square hole (111) connects the upper semi-hollow cylinder (100) and the lower semi-hollow cylinder (200) together to form a hollow cylinder.2.根据权利要求1所述的一种实验动物用人工视神经套管，其特征在于：所述上半空心圆柱体(100)和下半空心圆柱体(200)的内径相同，大小为0.1-3mm。2. a kind of artificial optic nerve cannula for experimental animals according to claim 1, is characterized in that: the inner diameter of described upper half hollow cylinder (100) and lower half hollow cylinder (200) are the same, and the size is 0.1- 3mm.3.根据权利要求1所述的一种实验动物用人工视神经套管，其特征在于：其制作材料为聚甲基丙烯酸甲酯。3. a kind of artificial optic nerve sleeve for experimental animals according to claim 1, is characterized in that: its making material is polymethyl methacrylate.

Images