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CN107045190A - Sample bearing module and portable microscope device - Google Patents

Sample bearing module and portable microscope device
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Publication number
CN107045190A
CN107045190ACN201710015923.8ACN201710015923ACN107045190ACN 107045190 ACN107045190 ACN 107045190ACN 201710015923 ACN201710015923 ACN 201710015923ACN 107045190 ACN107045190 ACN 107045190A
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China
Prior art keywords
module
sample
light
adhesive
sample carrying
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CN201710015923.8A
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Chinese (zh)
Inventor
林建明
陈昌佑
蒋存超
林书圣
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Aidmics Biotechnology Co ltd
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Aidmics Biotechnology Co ltd
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Application filed by Aidmics Biotechnology Co ltdfiledCriticalAidmics Biotechnology Co ltd
Priority to US15/416,386priorityCriticalpatent/US10495868B2/en
Priority to EP17153238.5Aprioritypatent/EP3203293B1/en
Priority to AU2017200620Aprioritypatent/AU2017200620A1/en
Priority to JP2017018695Aprioritypatent/JP6585642B2/en
Publication of CN107045190ApublicationCriticalpatent/CN107045190A/en
Pendinglegal-statusCriticalCurrent

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Abstract

The application relates to a sample bearing module and a portable microscope device. A portable microscope device is matched with an image acquisition module for use and comprises a sample bearing module, a light source module and a convex lens module. The sample bearing module comprises a body and an adhesion assembly, wherein the body is provided with a light transmission area and a sample observation surface. The adhesion assembly is removably adhered to the body and at least partially covers the light-transmitting area, so that the adhesion assembly is adjacent to the sample observation surface. The light source module is movably assembled at one side of the body and comprises a seat body and a light source. The base body is provided with a light outlet, and the sample bearing module is movably assembled at one side of the light outlet. The light source is arranged in the seat body. The convex lens module comprises at least one convex lens, the movable group of the convex lens is arranged on one side of the sample bearing module, is focused on the sample observation surface substantially and corresponds to the light source module.

Description

Translated fromChinese
样品承载模块与可携式显微镜装置Sample Carrier Module and Portable Microscope Unit

技术领域technical field

本发明可携式显微镜装置,尤指一种可与一智能型通讯装置搭配使用的可携式显微镜装置。The portable microscope device of the present invention particularly refers to a portable microscope device that can be used in conjunction with an intelligent communication device.

背景技术Background technique

一般传统显微镜多用于观察微生物、细胞或一些物质的细微结构,然而为了要能方便观察,需要先将待测物制作成易透光的薄切片样本,然后再将切片放置于载玻片上,接着在切片上滴上少量的液体(通常是水),最后在切片上盖上盖玻片,如此方能完成一个可供显微镜观察的标本。如果要保存利用上述方法制作的样本,更需要再利用其他的材料来将所制作的样本包覆起来,方能做成标本。Generally, traditional microscopes are mostly used to observe the microstructure of microorganisms, cells or some substances. However, in order to facilitate observation, it is necessary to make the object to be tested into a thin section sample that is easy to transmit light, and then place the section on a glass slide. Drop a small amount of liquid (usually water) on the slice, and finally cover the slice with a coverslip, so that a specimen for microscope observation can be completed. If the samples made by the above-mentioned method are to be preserved, it is necessary to use other materials to wrap the samples made so as to make specimens.

基于对科学追求真理的热情,期待能够随处观察环境中各式各样的生物、非生物样本(毛发、织品、写意等等)的细微结构与纹理,可携式的显微镜装置的设计便油然而生,例如美国专利第US20120157160号「Compact wide-field fluorescent imaging on amobile device」、中国台湾专利第M444520号「轻便型高倍显微放大镜头」、中国专利第CN200920005757.4号「多功能显微镜装置」等等,然而仅有可携式的显微装置并不足以大幅提升使用上的便利性,只要制作样本的方法依旧繁琐复杂,就不可能完全享受到能够随处观察的好处。因此,有需要提出一种可以搭配可携式的显微装置使用的样品承载模块,以达到随处观察的功效。Based on the enthusiasm for scientific pursuit of truth, looking forward to observing the microstructure and texture of various biological and non-biological samples (hair, fabric, freehand, etc.) in the environment, the design of the portable microscope device is spontaneous For example, U.S. Patent No. US20120157160 "Compact wide-field fluorescent imaging on a mobile device", Taiwan Patent No. M444520 "Portable High Power Micromagnification Lens", Chinese Patent No. CN200920005757.4 "Multifunctional Microscope Device", etc. etc. However, only portable microscopic devices are not enough to greatly improve the convenience of use. As long as the method of making samples is still cumbersome and complicated, it is impossible to fully enjoy the benefits of being able to observe anywhere. Therefore, there is a need to propose a sample carrying module that can be used with a portable microscopic device to achieve the effect of observation anywhere.

发明内容Contents of the invention

有鉴于上述课题,本发明的目的为提供一种能够可以搭配可携式的显微装置使用的样品承载模块。In view of the above problems, the object of the present invention is to provide a sample carrying module that can be used with a portable microscope device.

为达上述的目的,本发明的样品承载模块与可携式显微镜装置,与一影像撷取模块搭配使用,包括一样品承载模块、一光源模块以及一凸透镜模块。样品承载模块包括一本体以及一黏着组件,本体具有一通光区域与一样品观察面。黏着组件可移除地黏设于本体,且至少部份覆盖通光区域,使黏着组件邻接于样品观察面。光源模块活动组设于本体的一侧,且包括一座体以及一光源。座体具有一出光孔,样品承载模块活动组设于出光孔的一侧。光源设于座体中。凸透镜模块包括至少一凸透镜,其活动组设于样品承载模块的一侧,且实质上对焦于样品观察面,与光源模块相对应。一检测样本预先被黏着组件沾黏后,再将黏着组件黏设置于本体上,此时将光源模块沿之样品承载模块一侧组设以开启光源,然后再将凸透镜模块组设于样品承载模块的另一侧,光源模块所发出的光线穿过样品后进入凸透镜模块,操作者即可以影像撷取模块于凸透镜模块背后拍摄所述样本所成的实像。In order to achieve the above purpose, the sample carrying module and the portable microscope device of the present invention are used together with an image capture module, including a sample carrying module, a light source module and a convex lens module. The sample carrying module includes a body and an adhesive component. The body has a light-transmitting area and a sample observation surface. The adhesive component is removably adhered to the body, and at least partially covers the light-transmitting area, so that the adhesive component is adjacent to the sample observation surface. The light source module is movable and arranged on one side of the main body, and includes a base and a light source. The base body has a light exit hole, and the sample carrying module is movably arranged on one side of the light exit hole. The light source is arranged in the seat body. The convex lens module includes at least one convex lens, the movable group of which is arranged on one side of the sample carrying module, and substantially focuses on the sample observation surface, corresponding to the light source module. A test sample is pre-sticked by the adhesive component, and then the adhesive component is glued to the body. At this time, the light source module is assembled along the side of the sample carrying module to turn on the light source, and then the convex lens module is assembled on the sample carrying module. On the other side, the light emitted by the light source module passes through the sample and then enters the convex lens module. The operator can then use the image capture module to take a real image of the sample formed by the convex lens module.

在一实施例中,黏着组件为一透光组件。In one embodiment, the adhesive component is a transparent component.

在一实施例中,黏着组件为一贴纸。In one embodiment, the adhesive component is a sticker.

在一实施例中,黏着组件为一透光组件,具有一样品黏着面,且具有一黏着区及一非黏着区。In one embodiment, the adhesive component is a light-transmitting component, has a sample adhesive surface, and has an adhesive area and a non-adhesive area.

在一实施例中,黏着组件具有一黏着区及一非黏着区,黏着区包括一透光区及一不透光区。In one embodiment, the adhesive component has an adhesive area and a non-adhesive area, and the adhesive area includes a light-transmitting area and an opaque area.

在一实施例中,黏着组件为一透光组件,具有一样品黏着面,且具有一黏着区及一非黏着区,且黏着区具有辅助观测的一图样。In one embodiment, the adhesive component is a light-transmitting component, has a sample adhesive surface, and has an adhesive area and a non-adhesive area, and the adhesive area has a pattern for assisting observation.

在一实施例中,样品承载模块更包括至少一第一磁性组件,设于本体的一侧。In one embodiment, the sample carrying module further includes at least one first magnetic component disposed on one side of the body.

在一实施例中,样品承载模块更包括至少一第一磁性组件,设于本体的一侧,磁性连接于光源模块,或凸透镜模块。In one embodiment, the sample carrying module further includes at least one first magnetic component disposed on one side of the body and magnetically connected to the light source module or the convex lens module.

在一实施例中,光源模块更包括一第二磁性组件,设于座体,且磁性连接于样品承载模块,或凸透镜模块。In one embodiment, the light source module further includes a second magnetic component disposed on the base and magnetically connected to the sample carrying module or the convex lens module.

在一实施例中,凸透镜模块更包括一第三磁性组件,磁性连接于样品承载模块,或光源模块。In one embodiment, the convex lens module further includes a third magnetic component magnetically connected to the sample carrying module or the light source module.

在一实施例中,样品承载模块更包括至少一玻片,设于本体的一侧。In one embodiment, the sample carrying module further includes at least one glass slide disposed on one side of the main body.

在一实施例中,样品承载模块更包括至少一玻片,设于本体的一侧,且黏着组件可移除地黏设于玻片。In one embodiment, the sample carrying module further includes at least one slide disposed on one side of the main body, and the adhesive component is removably adhered to the slide.

在一实施例中,本体具有一凸部,设于本体的一侧。In one embodiment, the body has a protrusion disposed on one side of the body.

在一实施例中,座体具有一限位部,样品承载模块活动组设于限位部。In one embodiment, the seat body has a limiting portion, and the sample carrying module is movably arranged on the limiting portion.

在一实施例中,可携式显微镜装置更包括一组固定件,以固定凸透镜模块与影像撷取模块的相对位置。In one embodiment, the portable microscope device further includes a set of fixing parts for fixing the relative positions of the convex lens module and the image capture module.

在一实施例中,影像撷取模块为一智能型手机、一平板计算机、一笔记本电脑、一行车纪录器、一照相机或一自拍器的影像撷取模块。In one embodiment, the image capture module is an image capture module of a smart phone, a tablet computer, a notebook computer, a driving recorder, a camera or a Selfie.

在一实施例中,可携式显微镜装置更包括一第一偏光片及一第二偏光片,相对设置于样品承载模块两侧的光学路径上。In one embodiment, the portable microscope device further includes a first polarizer and a second polarizer, which are relatively arranged on the optical path at two sides of the sample carrying module.

为使贵审查委员得以清楚了解本发明的目的、技术特征及其实施后的功效,以下列说明搭配图示进行说明,敬请参阅。In order to enable your examining committee members to clearly understand the purpose, technical features and effects of the present invention after implementation, the following descriptions are provided together with illustrations, please refer to them.

附图说明Description of drawings

图1A为本发明可携式显微装置的一实施例的立体爆炸图。FIG. 1A is a three-dimensional exploded view of an embodiment of the portable microscopic device of the present invention.

图1B为本发明可携式显微装置搭配一可携式电子装置使用的一实施例的立体爆炸图。FIG. 1B is a three-dimensional exploded view of an embodiment of the portable microscopic device of the present invention used together with a portable electronic device.

图1C为本发明可携式显微装置的另一实施例的立体爆炸图。FIG. 1C is a three-dimensional exploded view of another embodiment of the portable microscopic device of the present invention.

图1D为本发明可携式显微装置搭配一可携式电子装置使用的另一实施例的立体爆炸图。FIG. 1D is a three-dimensional exploded view of another embodiment of the portable microscopic device of the present invention used together with a portable electronic device.

图2A为本发明样品承载模块的另一实施例的立体图。Fig. 2A is a perspective view of another embodiment of the sample carrying module of the present invention.

图2B为图2A的一变化态样的立体图。FIG. 2B is a perspective view of a variation of FIG. 2A .

图2C为图2A的另一变化态样的立体图。FIG. 2C is a perspective view of another variation of FIG. 2A .

图3A至图3E为图1A中黏着组件的其他态样俯视示意图。3A to 3E are schematic top views of other aspects of the adhesive component in FIG. 1A .

图4为本发明样品承载模块搭配常规载玻片使用的一实施例的示意图。Fig. 4 is a schematic diagram of an embodiment of the use of the sample carrying module of the present invention with a conventional glass slide.

具体实施方式detailed description

以下将参照相关附图,说明依本发明较佳实施例的一种光学观测装置,其中相同的组件将以相同的参照符号加以说明。An optical observation device according to a preferred embodiment of the present invention will be described below with reference to related drawings, wherein the same components will be described with the same reference symbols.

请参阅图1A及图1B,图1A为本发明可携式显微装置的一实施例的立体爆炸图。图1B为本发明可携式显微装置搭配一可携式电子装置使用的一实施例的立体爆炸图。可携式显微镜装置1与一可携式电子装置60的影像撷取模块61搭配使用。例如:可携式电子装置60为一智能型手机、一平板计算机、一笔记本电脑、一行车纪录器、一照相机或一自拍器。可携式显微镜装置1包括一样品承载模块10、一光源模块20以及一凸透镜模块30。Please refer to FIG. 1A and FIG. 1B . FIG. 1A is a three-dimensional exploded view of an embodiment of the portable microscopic device of the present invention. FIG. 1B is a three-dimensional exploded view of an embodiment of the portable microscopic device of the present invention used together with a portable electronic device. The portable microscope device 1 is used together with an image capturing module 61 of a portable electronic device 60 . For example: the portable electronic device 60 is a smart phone, a tablet computer, a notebook computer, a driving recorder, a camera or a Selfie. The portable microscope device 1 includes a sample carrying module 10 , a light source module 20 and a convex lens module 30 .

样品承载模块10包括一本体11以及一黏着组件12,本体11可为一载体承载黏着组件12及检测样本S,于此以本体11为一金属片为例,本体11还可具有一通光区域111、一凸部112、一限位件114与一样品观察面L。黏着组件12可为一透光组件,其透光率大于90%。黏着组件12可以是贴纸、胶带或是树脂,具有一样品黏着面,其可于沾黏一检测样本S后,黏贴于本体11形成一观测标本,即,黏着组件12以可移除地的方式黏设于本体11上。黏着组件12至少部份覆盖通光区域111,使黏着组件12邻接于样品观察面L。本实施例中,通光区域111只要是光线能通过的区域即可,可具有一开口或一透光物,于此通光区域111以一通光孔为例。The sample carrying module 10 includes a main body 11 and an adhesive component 12. The main body 11 can be a carrier carrying the adhesive component 12 and the detection sample S. Here, the main body 11 is a metal sheet as an example, and the main body 11 can also have a light-transmitting area 111. , a convex portion 112 , a limiting member 114 and a sample observation surface L. The adhesive component 12 can be a transparent component with a light transmittance greater than 90%. The adhesive component 12 can be a sticker, tape or resin, and has a sample adhesive surface, which can be pasted on the main body 11 to form an observation specimen after sticking a test sample S, that is, the adhesive component 12 can be removably The method is glued on the body 11. The adhesive component 12 at least partially covers the light-transmissive area 111 , so that the adhesive component 12 is adjacent to the sample observation surface L. In this embodiment, as long as the light-transmitting region 111 is a region through which light can pass, it can have an opening or a light-transmitting object. Here, the light-transmitting region 111 takes a light-through hole as an example.

光源模块20活动组设于样品承载模块10的本体11的一侧,且包括一座体21、一光源22、以及一开关23。座体21内呈中空状,使其可容置光源22及其他相关电路。座体21具有一出光孔211以及限位部212,限位部212与出光孔211位于座体21的同侧。光源22耦接于开关23,其所发出的光线可经过出光孔211射出座体21。限位部212具有一组沟槽C(如图4所示),当样品承载模块10活动组设于限位部212上时,其卡合于沟槽C中,此时凸部112会对应按压开关23,使得光源22被打开发出光线。在本实施例中,光源22所发出的光线为可见光。然而,在其他实施例中,光源22所发出的光线亦可以是非可见光,例如红外光光源、紫外光光源或拉曼光源等,只要影像撷取模块61的感光组件能够对应进行感光即可。举例来说,当光源22为紫外光光源时,可携式显微镜装置1便可为应用于生物细胞样本的计数的荧光检测器。凸透镜模块30包括一凸透镜31、一镜座32,凸透镜31嵌入于镜座32中。凸透镜模块30活动组设于样品承载模块10的一侧,且实质上对焦于样品观察面L,并与光源模块20相对应(如图1A所示),即光源模块20与凸透镜模块30分别组设于样品承载模块10不同的两侧。请参阅1B图,在本实施例中,可携式显微镜装置1更包括一组固定件33,固定件33具有一公次件331设置于镜座32上,以及一母次件332对应设置于影像撷取模块61上,在本实施例中,公次件331与母次件332分别具有互相匹配的一螺纹,彼此螺接,以达到固定凸透镜模块30a与影像撷取模块61的相对位置的功效。然而本实施例仅作为范例说明之用,并非作为本发明的限制条件,举例来说,固定件33亦可以是黏着剂、夹具、磁铁、吸盘、卡榫等,此外,如图1B所示,固定件33亦可整合于手机背盖或保护壳中。The light source module 20 is movably arranged on one side of the body 11 of the sample carrying module 10 , and includes a base 21 , a light source 22 , and a switch 23 . The inside of the seat body 21 is hollow, so that it can accommodate the light source 22 and other related circuits. The base body 21 has a light outlet hole 211 and a limiting portion 212 , the limiting portion 212 and the light outlet hole 211 are located on the same side of the base body 21 . The light source 22 is coupled to the switch 23 , and the light emitted by it can exit the base body 21 through the light exit hole 211 . The limiting portion 212 has a set of grooves C (as shown in FIG. 4 ). When the sample carrying module 10 is movably arranged on the limiting portion 212 , it engages in the grooves C. At this time, the convex portion 112 will correspond to Pressing the switch 23 causes the light source 22 to be turned on to emit light. In this embodiment, the light emitted by the light source 22 is visible light. However, in other embodiments, the light emitted by the light source 22 can also be non-visible light, such as an infrared light source, an ultraviolet light source or a Raman light source, as long as the photosensitive component of the image capture module 61 can sense light correspondingly. For example, when the light source 22 is an ultraviolet light source, the portable microscope device 1 can be a fluorescence detector for counting biological cell samples. The convex lens module 30 includes a convex lens 31 and a mirror seat 32 , and the convex lens 31 is embedded in the mirror seat 32 . The convex lens module 30 is movably arranged on one side of the sample carrying module 10, and is substantially focused on the sample observation surface L, and corresponds to the light source module 20 (as shown in FIG. 1A ), that is, the light source module 20 and the convex lens module 30 are assembled separately. They are arranged on different two sides of the sample carrying module 10 . Please refer to Figure 1B. In this embodiment, the portable microscope device 1 further includes a set of fixing parts 33. The fixing parts 33 have a male secondary part 331 arranged on the mirror base 32, and a female secondary part 332 correspondingly arranged on the On the image capture module 61, in this embodiment, the male secondary part 331 and the female secondary part 332 respectively have a thread that matches each other, and are screwed together to achieve the purpose of fixing the relative position of the convex lens module 30a and the image capture module 61. effect. However, this embodiment is only used as an example and not as a limitation of the present invention. For example, the fixing member 33 can also be an adhesive, a clamp, a magnet, a sucker, a tenon, etc. In addition, as shown in FIG. 1B , The fixing part 33 can also be integrated into the back cover or protective case of the mobile phone.

图1C为本发明可携式显微装置的另一实施例的立体爆炸图。如图1C所示,本体11a亦可为一载玻片。本实施例中,操作者仅需将沾黏有检测样本S的黏着组件12直接贴附于载玻片上,再将载玻片卡合于座体212的限位部212中,即完成检测样本S的设置。FIG. 1C is a three-dimensional exploded view of another embodiment of the portable microscopic device of the present invention. As shown in FIG. 1C , the body 11a can also be a glass slide. In this embodiment, the operator only needs to directly attach the adhesive assembly 12 with the test sample S attached to the glass slide, and then snap the glass slide into the limit portion 212 of the base 212 to complete the test sample. S settings.

图1D为本发明可携式显微装置搭配一可携式电子装置使用的另一实施例的立体爆炸图。如图1D所示,可携式显微镜装置1更可包括一第一偏光片40及一第二偏光片50,相对设置于样品承载模块10两侧的光学路径上,以观察具有双折射性质的检测样本S,例如:淀粉的结晶或昆虫的复眼。第一偏光片40及第二偏光片50可为线性偏光片,于预设情况下,第一偏光片40及第二偏光片50的偏振轴方向互相垂直。此外,第一偏光片40及第二偏光片50亦可为圆偏光片或楕圆偏光片。FIG. 1D is a three-dimensional exploded view of another embodiment of the portable microscopic device of the present invention used together with a portable electronic device. As shown in FIG. 1D, the portable microscope device 1 may further include a first polarizer 40 and a second polarizer 50, which are relatively arranged on the optical path on both sides of the sample carrying module 10, so as to observe the birefringence Test sample S, for example: crystals of starch or compound eyes of insects. The first polarizer 40 and the second polarizer 50 may be linear polarizers, and in a default condition, the directions of the polarization axes of the first polarizer 40 and the second polarizer 50 are perpendicular to each other. In addition, the first polarizer 40 and the second polarizer 50 can also be circular polarizers or elliptic circular polarizers.

第一偏光片40可设置于检测样本S与影像撷取模块61之间的光学路径上,第二偏光片50可设置于检测样本S与光源模块20之间的光学路径上。于本实施例中,第一偏光片40是设置于凸透镜模块30与影像撷取模块61之间,故可先将第一偏光片40装设于凸透镜模块30上再一并固定于影像撷取模块61,亦可将第一偏光片40直接贴附于影像撷取模块61上。第二偏光片50则设置于样品承载模块10与光源模块20之间,例如:第二偏光片50可装设于出光孔211处或贴附于样品承载模块10靠近出光孔211的一侧。The first polarizer 40 can be disposed on the optical path between the detection sample S and the image capture module 61 , and the second polarizer 50 can be disposed on the optical path between the detection sample S and the light source module 20 . In this embodiment, the first polarizer 40 is arranged between the convex lens module 30 and the image capture module 61, so the first polarizer 40 can be installed on the convex lens module 30 first and then fixed on the image capture module. The module 61 can also directly attach the first polarizer 40 to the image capture module 61 . The second polarizer 50 is disposed between the sample carrying module 10 and the light source module 20 , for example, the second polarizer 50 can be installed at the light exit hole 211 or attached to the side of the sample carrying module 10 close to the light exit hole 211 .

当光源模块20开启时,若第一偏光片40及第二偏光片50的偏振轴方向互相垂直,且样品承载模块10承载了不具有双折射性质的检测样本S时,用户将无法看到检测样本S的成像。当样品承载模块10承载了具有双折射性质的检测样本S时,光源22所发出的光线将依序通过第二偏光片50、检测样本S、凸透镜模块30及第一偏光片40,而到达影像撷取模块61,操作者即可以影像撷取模块61拍摄检测样本S的成像。此外,由于第一偏光片40固定于影像撷取模块61上,操作者可借由旋转座体21,以改变第二偏光片50的偏振轴角度,使不同偏振角度的光通过检测样本S,借此可观察检测样本S中不同相的结构与型态,例如:在偏光模式下,不需经由染色,即可清楚观察到淀粉结晶的微观结构。When the light source module 20 is turned on, if the polarization axes of the first polarizer 40 and the second polarizer 50 are perpendicular to each other, and the sample carrying module 10 carries a test sample S that does not have birefringence properties, the user will not be able to see the detection sample S. Imaging of sample S. When the sample carrying module 10 carries the detection sample S with birefringence properties, the light emitted by the light source 22 will pass through the second polarizer 50, the detection sample S, the convex lens module 30 and the first polarizer 40 in sequence, and reach the image The capture module 61 , the operator can use the image capture module 61 to take an image of the test sample S. In addition, since the first polarizer 40 is fixed on the image capture module 61, the operator can change the angle of the polarization axis of the second polarizer 50 by rotating the base 21, so that light with different polarization angles passes through the detection sample S, In this way, the structures and types of different phases in the test sample S can be observed. For example, in the polarized light mode, the microstructure of starch crystals can be clearly observed without dyeing.

需注意的是,在上述的实施例中的「活动组设」透过磁力吸附的方式来达成,即,样品承载模块10、光源模块20或凸透镜模块30至少其一包括一磁性组件。在一较佳实施例中,样品承载模块10包括第一磁性组件(未绘示),此时光源模块20可包括对应第一磁性组件的第二磁性组件(未绘示)设置于座体21,亦或座体21可为导磁材质所制成;凸透镜模块30亦可包括对应第一磁性组件的第三磁性组件(未绘示)设置于镜座32,亦或镜座32可为导磁材质所制成。当第一磁性组件是磁铁时,第二磁性组件及/或第三磁性组件可以是磁铁或磁性金属;当第二磁性组件是磁铁,此时第一磁性组件可以是磁铁或磁性金属,第三磁性组件是磁铁;当第三磁性组件是磁铁,此时第一磁性组件可以是磁铁或磁性金属,第二磁性组件是磁铁。It should be noted that the "movable assembly" in the above-mentioned embodiments is achieved through magnetic adsorption, that is, at least one of the sample carrying module 10 , the light source module 20 or the convex lens module 30 includes a magnetic component. In a preferred embodiment, the sample carrying module 10 includes a first magnetic component (not shown), at this time the light source module 20 may include a second magnetic component (not shown) corresponding to the first magnetic component disposed on the base 21 , or the base body 21 can be made of a magnetically conductive material; the convex lens module 30 can also include a third magnetic component (not shown) corresponding to the first magnetic component and be arranged on the mirror base 32, or the mirror base 32 can be a guide Made of magnetic material. When the first magnetic component is a magnet, the second magnetic component and/or the third magnetic component can be a magnet or a magnetic metal; when the second magnetic component is a magnet, the first magnetic component can be a magnet or a magnetic metal, and the third magnetic component can be a magnet or a magnetic metal. The magnetic component is a magnet; when the third magnetic component is a magnet, the first magnetic component can be a magnet or magnetic metal, and the second magnetic component is a magnet.

承上所述,本发明的可携式显微镜装置1搭配可携式电子装置60操作时,凸透镜模块30固定在可携式电子装置60上,样品承载模块10与光源模块20分别透过限位件114与限位部212互相卡合,且凸透镜模块30与样品承载模块10之间透过磁力活动组设,此时样品承载模块10与光源模块20之间不会相对滑动,凸透镜模块30与可携式电子装置60之间也不会相对滑动,样品承载模块10与凸透镜模块30之间则可相对滑动,借此达到移动可携式显微装置1的功效,使得检测样本S可以正确位于可携式电子装置60的镜头视野中。Based on the above, when the portable microscope device 1 of the present invention is operated with the portable electronic device 60, the convex lens module 30 is fixed on the portable electronic device 60, and the sample carrying module 10 and the light source module 20 pass through the limiter respectively. The component 114 and the stopper 212 are engaged with each other, and the convex lens module 30 and the sample carrying module 10 are movable and assembled through magnetic force. At this time, the sample carrying module 10 and the light source module 20 will not slide relative to each other, and the convex lens module 30 and the The portable electronic device 60 will not slide relative to each other, but the sample carrying module 10 and the convex lens module 30 can slide relative to each other, so as to achieve the effect of moving the portable microscopic device 1, so that the detection sample S can be correctly positioned In the field of view of the lens of the portable electronic device 60 .

请参阅图2A至图2C,图2A为本发明样品承载模块的另一实施例的立体图。图2B为图2A的一变化态样的立体图。图2C为图2A的另一变化态样的立体图。在图2A至图2C中,样品承载模块10a、10b或10c的组成大致相似于样品承载模块10,不同之处在于样品承载模块10a、10b或10c皆另包括有一透光组件113。为了方便说明样品承载模块10a、10b或10c与样品承载模块10的不同之处,在图2A至图2C中省略了绘示黏着组件12,关于黏着组件12的说明将详述于后面的段落。如图2A所示,在样品承载模块10a中,透光组件113设置于本体11具有凸部112的同侧。如图2B所示,在样品承载模块10b中,透光组件113设置于本体11具有凸部112的反侧。如图2C所示,在样品承载模块10c中,透光组件113直接嵌入于通光区域111中。透光组件113可以是一玻片、塑料片、或树脂片。请注意,由于透光组件113具有通光的性质,在另一实施例中,在环境光充足的情况下时,透光组件113可以将部分环境光引入,使得可携式显微镜装置1亦可于光源22不开启的情况下使用,此时影像撷取模块61仍然可以观察到的标本,并且所观察到的画面会具有暗场的效果。Please refer to FIG. 2A to FIG. 2C . FIG. 2A is a perspective view of another embodiment of the sample carrying module of the present invention. FIG. 2B is a perspective view of a variation of FIG. 2A . FIG. 2C is a perspective view of another variation of FIG. 2A . In FIGS. 2A to 2C , the composition of the sample carrying module 10 a , 10 b or 10 c is roughly similar to that of the sample carrying module 10 , except that the sample carrying module 10 a , 10 b or 10 c further includes a light-transmitting component 113 . In order to facilitate the description of the difference between the sample carrying module 10a, 10b or 10c and the sample carrying module 10, the adhesive component 12 is omitted in FIG. 2A to FIG. As shown in FIG. 2A , in the sample carrying module 10 a, the light-transmitting component 113 is disposed on the same side of the body 11 as the convex portion 112 . As shown in FIG. 2B , in the sample carrying module 10 b , the light-transmitting component 113 is disposed on the opposite side of the body 11 with the convex portion 112 . As shown in FIG. 2C , in the sample carrying module 10c, the light-transmitting component 113 is directly embedded in the light-transmitting region 111 . The light-transmitting component 113 can be a glass sheet, a plastic sheet, or a resin sheet. Please note that since the light-transmitting component 113 has the property of passing light, in another embodiment, when the ambient light is sufficient, the light-transmitting component 113 can introduce part of the ambient light, so that the portable microscope device 1 can also When the light source 22 is not turned on, the image capture module 61 can still observe the specimen at this time, and the observed picture will have the effect of dark field.

图3A至图3E为黏着组件的其他态样俯视示意图。请参阅图3A至图3C所示,黏着组件12可为一透光组件,其透光率大于90%。黏着组件12具有一黏着区121与非黏着区122,黏着区121用来沾黏检测样本S,其后再黏附于透光组件113上,黏着区121的直径不大于2.5公分;非黏着区122为用户拿取黏着组件12的部分。在一实施例中,黏着区121与非黏着区122之间可具有一半断切割线(easy tearing line)T,当使用者想要保存所黏的检测样本S时,可于将黏着组件12黏于保存区(例如,一黏贴簿或是一载玻片)后,将非黏着区122自黏着组件12撕除。黏着组件12在黏着区121所对应的区域中(可在黏着面上或非黏着面上)具有辅助观测的一图样P,图样P可以是由印刷的方式形成的规律几何图样或是复杂花纹图样。当用户在使用可携式显微镜装置1时,会需要调整移动样品承载模块10、10a、10b或10c来使检测样本S落入影像撷取模块61的镜头视野中,然而当使用者透过可携式显微镜装置1观看时,并不容易分辨检测样本S与影像撷取模块61的镜头视野之间的相对位置,此时图样P可以辅助用户快速找到检测样本S与影像撷取模块61的镜头视野之间的相对位置,举例来说,在一实施例中,图样P可以是沿设于黏着区121的边缘,如图3A所示,用户若在影像撷取模块61的镜头视野中看到图样P,便可知道目前影像撷取模块61的镜头视野位于黏着区121的边缘,使用者便知道要往反方向调整样品承载模块10、10a、10b或10c;在另一实施例中,图样P可以是具有指向性的图案(例如,环形、米字形或十字形),如图3B所示,图样P为一十字图样,位于黏着区121的正中心,当用户在影像撷取模块61的镜头视野中看到图样P时,便会知道目前影像撷取模块61的镜头视野已对准黏着区121的中心。此外,当用户透过可携式显微镜装置1观看时,会想要知道所观测到检测样本S实际上的大小,因此在另一实施例中,如图3C所示,图样P是一尺标,如此用户便可直接在影像撷取模块61的镜头视野中得知检测样本S的大小。3A to 3E are schematic top views of other aspects of the adhesive component. Please refer to FIG. 3A to FIG. 3C , the adhesive component 12 can be a light-transmitting component, and its light transmittance is greater than 90%. The adhesive component 12 has an adhesive area 121 and a non-adhesive area 122. The adhesive area 121 is used to stick the detection sample S, and then adhere to the light-transmitting component 113. The diameter of the adhesive area 121 is not greater than 2.5 cm; the non-adhesive area 122 Take part of the adhesive assembly 12 for the user. In one embodiment, there may be an easy tearing line T between the adhesive area 121 and the non-adhesive area 122. When the user wants to save the attached test sample S, the adhesive component 12 can be attached The non-adhesive area 122 is peeled off from the adhesive component 12 after the storage area (eg, a scrapbook or a glass slide). Adhesive component 12 has a pattern P to assist observation in the area corresponding to the adhesive area 121 (it can be on the adhesive surface or the non-adhesive surface). The pattern P can be a regular geometric pattern or a complex pattern pattern formed by printing. . When the user is using the portable microscope device 1, it is necessary to adjust the moving sample carrying module 10, 10a, 10b or 10c to make the detection sample S fall into the lens field of view of the image capturing module 61. When the portable microscope device 1 is viewed, it is not easy to distinguish the relative position between the test sample S and the lens field of view of the image capture module 61. At this time, the pattern P can help the user quickly find the test sample S and the lens of the image capture module 61. The relative positions between the fields of view, for example, in one embodiment, the pattern P can be set along the edge of the adhesive area 121, as shown in FIG. 3A, if the user sees the With the pattern P, it can be known that the lens field of view of the image capture module 61 is located at the edge of the adhesive area 121, and the user knows to adjust the sample carrying module 10, 10a, 10b or 10c in the opposite direction; in another embodiment, the pattern P can be a directional pattern (for example, ring, P-shaped or cross), as shown in FIG. When the pattern P is seen in the field of view of the lens, it will be known that the field of view of the lens of the image capture module 61 is aligned with the center of the adhesive area 121 . In addition, when the user looks through the portable microscope device 1, he will want to know the actual size of the observed test sample S, so in another embodiment, as shown in Figure 3C, the pattern P is a scale , so that the user can directly know the size of the detection sample S in the field of view of the lens of the image capture module 61 .

此外,黏着组件12亦可设置遮光区域,以形成一暗场(dark field)贴纸。如图3D所示,黏着区121包括一透光区124及一不透光区123。于图3D的实施态样中,不透光区123为一印刷黑点,且可设置于黏着区121的任何位置,不一定要设置于黏着区121的中心位置,只要检测样本S的成像背景呈现出暗场的效果即可。不透光区123亦可由多个分散的印刷黑点构成。因此,仅需于原本整体透光的黏着组件12上设置一个或多个分散的印刷黑点,以形成遮光区域,尽量只让折射和散射的光线射至检测样本S,即可达到暗场的效果,以提升分辨率。In addition, the adhesive component 12 can also be provided with a light-shielding area to form a dark field sticker. As shown in FIG. 3D , the adhesive area 121 includes a transparent area 124 and an opaque area 123 . In the embodiment shown in FIG. 3D , the opaque area 123 is a printed black dot, and can be placed at any position of the adhesive area 121, not necessarily at the center of the adhesive area 121, as long as the imaging background of the sample S is detected It can show the effect of dark field. The opaque area 123 can also be formed by a plurality of scattered printed black dots. Therefore, it is only necessary to set one or more scattered printed black dots on the adhesive component 12 that is originally transparent as a whole to form a light-shielding area, so that only the refracted and scattered light hits the test sample S as much as possible, and the dark field effect can be achieved. effect to increase the resolution.

于另一实施态样中,如图3E所示,黏着区121包括一透光区126及一不透光区125,不透光区125以环状方式呈现。透光区126可设置于黏着区121的任何位置,不一定要位于黏着区121的中心,只要检测样本S的成像背景呈现出暗场的效果即可。因此,仅需于原本整体透光的黏着组件12上设置一环状遮光区域,即可让黏着组件12成为一暗场贴纸。此外,图3D与图3E的态样亦可结合使用。借由暗场贴纸的设计方式,可提高样品本身与背景之间的对比,进而获得较佳的成像效果。In another embodiment, as shown in FIG. 3E , the adhesive region 121 includes a light-transmitting region 126 and a light-impermeable region 125 , and the light-impermeable region 125 is presented in a ring shape. The light-transmitting area 126 can be disposed at any position of the adhesive area 121 , not necessarily at the center of the adhesive area 121 , as long as the imaging background of the detection sample S presents a dark field effect. Therefore, it is only necessary to set an annular light-shielding area on the originally transparent adhesive component 12 to make the adhesive component 12 a dark field sticker. In addition, the aspects of FIG. 3D and FIG. 3E can also be used in combination. With the design method of the dark field sticker, the contrast between the sample itself and the background can be improved, and a better imaging effect can be obtained.

在另一实施例中,样品承载模块10与光源模块20可搭配一常规载玻片使用,使得本发明可携式显微装置1可兼容于传统载玻片样本。请参阅图4,图4为本发明样品承载模块搭配常规载玻片使用的一实施例的示意图。如图4所示,常规载玻片G卡合于限位部212中,样品承载模块10活动组设于限位部212上时,卡合于沟槽C中,此时样品承载模块10会些微按压于常规载玻片G,以避免常规载玻片G于限位部212中滑动。在本实施例中,黏着组件12亦可搭配常规载玻片G使用,即,黏着组件12可直接黏设于常规载玻片G来形成可观察的玻片标本。In another embodiment, the sample carrying module 10 and the light source module 20 can be used with a conventional glass slide, so that the portable microscopic device 1 of the present invention can be compatible with the conventional glass slide sample. Please refer to FIG. 4 . FIG. 4 is a schematic diagram of an embodiment in which the sample carrying module of the present invention is used with a conventional slide glass. As shown in FIG. 4 , the conventional slide glass G is engaged in the limiting portion 212, and when the sample carrying module 10 is movably set on the limiting portion 212, it is engaged in the groove C. At this time, the sample carrying module 10 will Slightly press the conventional slide glass G to prevent the conventional slide glass G from sliding in the limiting part 212 . In this embodiment, the adhesive assembly 12 can also be used with the conventional slide glass G, that is, the adhesive assembly 12 can be directly attached to the conventional slide glass G to form an observable slide glass specimen.

唯,以上所述者,仅为本发明的较佳的实施例而已,并非用以限定本发明实施的范围;任何熟习此技艺者,在不脱离本发明的精神与范围下所作的均等变化与修饰,皆应涵盖于本发明的专利范围内。Only, the ones described above are only preferred embodiments of the present invention, and are not intended to limit the scope of the present invention; anyone skilled in this art can make equivalent changes and changes without departing from the spirit and scope of the present invention. Modifications should all be covered within the patent scope of the present invention.

Claims (23)

Translated fromChinese
1.一种样品承载模块,其与一光源模块搭配使用,包括:1. A sample carrying module, which is used in conjunction with a light source module, comprising:一本体,具有一通光区域与一样品观察面;以及a body having a light-transmitting area and a sample viewing surface; and一黏着组件,可移除地黏设于所述本体,且至少部份覆盖所述通光区域,以使所述黏着组件邻接于所述样品观察面。An adhesive component is removably adhered to the body and at least partially covers the light-transmissive area, so that the adhesive component is adjacent to the sample observation surface.2.如权利要求1所述的样品承载模块,其中所述黏着组件为一透光组件。2. The sample carrying module according to claim 1, wherein the adhesive component is a light-transmitting component.3.如权利要求2所述的样品承载模块,其中所述黏着组件为一贴纸。3. The sample carrying module of claim 2, wherein the adhesive component is a sticker.4.如权利要求1所述的样品承载模块,其中所述黏着组件具有一样品黏着面,且具有一黏着区及一非黏着区。4. The sample carrying module according to claim 1, wherein the adhesive component has a sample adhesive surface, and has an adhesive area and a non-adhesive area.5.如权利要求4所述的样品承载模块,其中所述黏着区具有辅助观测的一图样。5. The sample carrying module as claimed in claim 4, wherein the adhesive area has a pattern for assisting observation.6.如权利要求4所述的样品承载模块,其中所述黏着区包括一透光区及一不透光区。6. The sample carrying module as claimed in claim 4, wherein the adhesive area comprises a light-transmitting area and a light-impermeable area.7.如权利要求1所述的样品承载模块,更包括:至少一第一磁性组件,设于所述本体的一侧。7. The sample carrying module as claimed in claim 1, further comprising: at least one first magnetic component disposed on one side of the body.8.如权利要求1所述的样品承载模块,更包括:一玻片,设于所述本体的一侧。8. The sample carrying module as claimed in claim 1, further comprising: a glass slide disposed on one side of the body.9.如权利要求8所述的样品承载模块,其中所述黏着组件可移除地黏设于所述玻片。9. The sample carrying module as claimed in claim 8, wherein the adhesive component is removably attached to the glass slide.10.如权利要求1所述的样品承载模块,其中所述本体具有一凸部,设于所述本体的一侧。10. The sample carrying module as claimed in claim 1, wherein the body has a protrusion disposed on one side of the body.11.一种可携式显微镜装置,其与一影像撷取模块搭配使用,包括:11. A portable microscope device, which is used in conjunction with an image capture module, comprising:一样品承载模块,包括一本体以及一黏着组件,所述本体具有一通光区域与一样品观察面;所述黏着组件可移除地黏设于所述本体,且至少部份覆盖所述通光区域,使所述黏着组件邻接于所述样品观察面;A sample carrying module, including a body and an adhesive component, the body has a light-transmitting area and a sample observation surface; the adhesive component is removably attached to the body, and at least partially covers the light-transmitting an area where the adhesive assembly is adjacent to the sample viewing surface;一光源模块,其活动组设于所述本体的一侧,且包括一座体以及一光源,所述座体具有一出光孔,所述样品承载模块活动组设于所述出光孔的一侧,所述光源设于所述座体中;以及A light source module, the movable group is arranged on one side of the body, and includes a base and a light source, the base has a light exit hole, and the sample carrying module is movable set on one side of the light exit hole, the light source is disposed in the seat; and一凸透镜模块,包括至少一凸透镜,所述凸透镜模块实质上对焦于所述样品观察面,且与所述光源模块对应,且活动组设于所述样品承载模块的一侧。A convex lens module includes at least one convex lens, the convex lens module is substantially focused on the sample observation surface, corresponds to the light source module, and is movably arranged on one side of the sample carrying module.12.如权利要求11所述的可携式显微镜装置,其中所述黏着组件为一透光组件。12. The portable microscope device as claimed in claim 11, wherein the adhesive component is a light-transmitting component.13.如权利要求12所述的可携式显微镜装置,其中所述黏着组件为一贴纸。13. The portable microscope device as claimed in claim 12, wherein the adhesive component is a sticker.14.如权利要求11所述的可携式显微镜装置,其中所述黏着组件具有一样品黏着面,且具有一黏着区及一非黏着区。14. The portable microscope device as claimed in claim 11, wherein the adhesive component has a sample adhesive surface, and has an adhesive area and a non-adhesive area.15.如权利要求14所述的可携式显微镜装置,其中所述黏着区具有辅助观测的一图样。15. The portable microscope device as claimed in claim 14, wherein the adhesive area has a pattern for assisting observation.16.如权利要求14所述的可携式显微镜装置,其中所述黏着区包括一透光区及一不透光区。16. The portable microscope device as claimed in claim 14, wherein the adhesive area comprises a light-transmitting area and a light-impermeable area.17.如权利要求11所述的可携式显微镜装置,其中所述光源模块更包括一第二磁性组件,设于所述座体,且磁性连接于所述样品承载模块,或所述凸透镜模块。17. The portable microscope device as claimed in claim 11, wherein the light source module further comprises a second magnetic component, which is arranged on the base body and magnetically connected to the sample carrying module or the convex lens module .18.如权利要求11所述的可携式显微镜装置,其中所述凸透镜模块更包括:一第三磁性组件,且磁性连接于所述样品承载模块,或所述光源模块。18. The portable microscope device as claimed in claim 11, wherein the convex lens module further comprises: a third magnetic component, which is magnetically connected to the sample carrying module or the light source module.19.如权利要求11所述的可携式显微镜装置,其中所述样品承载模块更包括至少一第一磁性组件,设于所述本体的一侧,磁性连接于所述光源模块,或所述凸透镜模块。19. The portable microscope device as claimed in claim 11, wherein the sample carrying module further comprises at least one first magnetic component, disposed on one side of the body, magnetically connected to the light source module, or the Convex lens module.20.如权利要求11所述的可携式显微镜装置,其中所述座体具有一限位部,所述样品承载模块活动组设于所述限位部。20. The portable microscope device as claimed in claim 11, wherein the base body has a limiting portion, and the sample carrying module is movably assembled on the limiting portion.21.如权利要求11所述的可携式显微镜装置,更包括:一组固定件,以固定所述凸透镜模块与所述影像撷取模块的相对位置。21. The portable microscope device as claimed in claim 11, further comprising: a set of fixing parts for fixing the relative positions of the convex lens module and the image capturing module.22.如权利要求21所述的可携式显微镜装置,其中所述影像撷取模块为一智能型手机、一平板计算机、一笔记本电脑、一行车纪录器、一照相机或一自拍器的影像撷取模块。22. The portable microscope device as claimed in claim 21, wherein the image capture module is an image capture of a smart phone, a tablet computer, a notebook computer, a driving recorder, a camera or a Selfie Take the module.23.如权利要求11所述的可携式显微镜装置,更包括:23. The portable microscope device of claim 11, further comprising:一第一偏光片及一第二偏光片,相对设置于所述样品承载模块两侧的光学路径上。A first polarizer and a second polarizer are relatively arranged on the optical path on both sides of the sample carrying module.
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CN107045191B (en)2020-06-16
JP2017138603A (en)2017-08-10
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JP6521331B2 (en)2019-05-29
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CN107045188A (en)2017-08-15
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JP2017160419A (en)2017-09-14
JP6745734B2 (en)2020-09-02

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