Embodiment
In one embodiment, as shown in figure 1, a kind of pacemaking generation device, including detection pace the impedance value of object simultaneouslyThe impedance detection module 100 of output, applies pacemaker impulse to the pacemaker impulse sending module 200 for pacing object, receives initial riseFight electric current, according to initial pacemaker current calculate obtain initial pace-making vector and by the initial pace-making vector export to pace-making arteries and veinsThe first processor 300 of sending module 200 is rushed, according to the second processor of impedance value and initial pacemaker current output regulation signal400, and receive Regulate signal and pace-making vector is adjusted according to Regulate signal and exports the pace-making vector after adjustment to pace-makingThe pace-making boost module 500 of pulse sending module 200；
Impedance detection module 100 is connected with second processor 400, pacemaker impulse sending module 200 and first processor 300Connection, first processor 300 is connected with second processor 400, and second processor 400 is connected with pace-making boost module 500, is pacedBoost module 500 is connected with pacemaker impulse sending module 200.
Wherein, pace-making object refers to the effective object of pacemaking generation device, and the effective object of pacemaking generation device can beSevere cardiac skip slowly, heart contraction is powerless or patient of cardiac arrest.
Structure in the one embodiment of impedance detection module 100 is as shown in Fig. 2 the carrier wave shaping circuit including being sequentially connected110th, capacitance coupling circuit 120, differential amplifier circuit 130, bandwidth-limited circuit 140 and filter rectifier 150, at firstReason device 300 sends the square wave for the 30KHz frequencies that dutycycle is 50%, is shaped as sine wave through carrier wave shaping circuit 110, passes through electricityHold termination power 120 to be loaded on human body, then pass through the differential amplification of the signal of 130 pairs of differential amplifier circuit coupling, band logicalThe analog-digital converter of first processor 300 is sent into after the filtering of filter circuit 140 and the filter rectification of filter rectifier 150Carry out sampling processing.To ensure the accuracy of impedance measurement, impedance detection module 100 need to be calibrated, using 2 points of calibrationsMethod.
Pacemaker impulse sending module 200 is as shown in figure 3, pace-making vector sample circuit, pace-making object including being sequentially connectedVoltage sampling circuit, constant-current source circuit and pacemaker current sample circuit.Pacemaking generation device receive first host computer instruct intoEnter noninvasive pacing mode, set initial pacemaker current I, according to the pace-making Ω of object maximum impedance 750, set initial pace-making electricityPress the initial pacemaker current * 750 of PACE_PWR=.According to the initial pacemaker current of setting, the control digital-to-analogue conversion of first processor 300Device DAC exports constant constant-current source driving voltage VDAC=I* (R5+R6), if risen according to driving voltage now to Low ESRObject of fighting is paced, and metal-oxide-semiconductor Q3 will bear very big voltage V1, is caused Q3 heatings serious, is increased the hair of pacemaking generation deviceHeat and power consumption, carry out real-time sampling to pace-making object voltage V2 during pace-making, are carried out according to the pace-making object voltage of samplingThe adjustment of pace-making vector, pace-making vector PACE_PWR=V1+I* (R5+R6)+V2.According to the special parameter of component, in electric currentIn the case of scope is confirmable, to ensure that the pressure drop of Q3 in the normal work of circuit, circuit is confirmable, metal-oxide-semiconductor can be setQ3 pressure drop is a fixed value V3.It is determined that after Q3 pressure drop, being adjusted to pace-making vector, pace-making vector PACE_PWR=V2+ I* (R5+R6)+V3 or multiplied by with a fixed coefficient, according to the pace-making object voltage V2 measured in real time, enter to pace-making vectorMobile state is adjusted, and the voltage for making to be loaded on Q3 is a constant value, can reduce Q3 caloric value, reduces power consumption.
First processor 300 and second processor 400 can be digital signal processors, and digital signal processor is by bigThe processor for being used for completing certain signal processing tasks of scale or VLSI chip composition, it is high to adapt toGradually grow up the need for fast real time signal processing task, with integrated circuit technique and digital signal processing algorithmDevelopment, the implementation method of digital signal processor is also being continually changing, and processing function is improved constantly and expanded.
Pace-making boost module 500 is as shown in figure 4, digital regulation resistance circuit, voltage-regulation feedback electricity including being sequentially connectedRoad and flyback transformer.Feedback current is adjusted by changing the resistance of digital regulation resistance, so as to change second processorPWM (Pulse Width Modulation, pulse width modulation) feedback voltage in 400, and then change PWM output dutyThan driving flyback transformer to complete the regulation of pace-making vector finally by PWM controls；First processor 300 passes through IIC(Inter-Integrated Circuit, IC bus) interface sends corresponding number to digital regulation resistance U4 registerAccording to changing the resistance value of digital regulation resistance.U3 is a three-terminal voltage-stabilizing diode, and reference edge node voltage is that U3 4 pin are stableIn 2.5V.Pace-making vector provides bias current for voltage-regulator diode, and VFB is the feedback end of PWM controls, pace-making vector PACE_PWRIt is also the output end of flyback transformer simultaneously, pace-making vector regulation circuit is isolated by optocoupler with the PWM feedback ends controlled.It is firstFirst, initial pace-making vector is obtained according to setup algorithm, first processor passes through past digital regulation resistance according to initial pace-making vector valueRegister in corresponding data are write to change the resistance value of digital regulation resistance, and then change the electricity at reference voltage terminal two endsResistance, the resistance at reference voltage terminal two ends is Rx, and digital regulation resistance constitutes adjustable current source with R3 resistance.Digital regulation resistance electricityThe change of resistance can cause the change of feedback branch electric current, and then cause PWM control feedback ends VFB change, so as to change PWM'sDutycycle, finally realizes the regulation of pace-making vector, pace-making vector PACE_PWR=2.5 (Rx+R3)/Rx.
Above-mentioned pacemaking generation device, first processor 300 obtains initial pace-making vector according to initial pacemaker current, will be initialPace-making vector is exported to pacemaker impulse sending module 200, and pacemaker impulse sending module 200 exports pacemaker impulse to pacing object,The impedance value and initial pacemaker current for the pace-making object that second processor 400 is detected according to impedance detection module 100 are generatedRegulate signal is to boost module 500 is paced, and pace-making boost module 500 adjusts pace-making vector according to the Regulate signal, after adjustmentPace-making vector export to pacemaker impulse sending module 200, such pacemaking generation device passes through two processors monitoring pace-makingsPulse is exported, and can effectively ensure that the electric current and voltage security for being carried in pace-making object, so as to ensure to pace the safety of object.
In one embodiment, pacemaking generation device is counted respectively using first processor 300 and second processor 400When, concrete structure block diagram is as shown in figure 5, host computer sends pacing frequency to second processor 400, second processor by serial portsPacing frequency is transmitted to first processor 300 by 400 by serial ports, now starts pace-making, and first processor 300 is fixed by insideWhen device pacemaker impulse is sent to pacing object by pacemaker impulse sending module 200 according to the pacing frequency of setting, the first processingDevice 300 exports PACE markers while pacemaker impulse is sent by IO (Input/Ouput, input and output) mouth, shouldPACE markers capture PACE letters by giving second processor 400, second processor 400 after magnetic coupling isolation circuit 600Number mark carries out the calculating of PACE frequencies, and is compared obtained frequency is calculated with setpoint frequency, if frequency unanimously ifExpression pacemaking generation device is normal condition, can perform next step action；Second processor control is closed if frequency is inconsistentThe output for pulse module of fighting is shut to stop pace-making, and sends failure code.
In one embodiment, host computer sends the initial pacemaker current set to second processor, and second processor is led toCross serial ports and be transmitted to first processor, first processor calculates and obtains initial pace-making vector, while passing through ADC pairs of analog-digital converterPace-making vector is sampled, and whether judge pace-making vector is setting value, if not being setting value, first processor control pace-makingPulse sending module closes pacemaker impulse or sends pace-making abnormal signal to second processor by serial ports, and second processor is closedClose the output of pace-making vector.Simultaneously by by pace-making vector PACE_PWR by after R7 and R8 partial pressures with fixed reference voltageVREF forms over-pressed hardware comparison circuit, over-pressed hardware comparison circuit as shown in fig. 6, when over-pressed hardware comparison circuit detects hairOver-pressed signal is sent during raw overvoltage, the over-pressed signal can be sent to first processor, first processor receives overvoltage letterNumber, control pacemaker impulse sending module closes the output of pacemaker impulse, to stop pace-making；Can also be by isolation optocoupler by overvoltageSignal feeds back to the power management chip of second processor and pacemaking generation device, second processor control pace-making boost moduleThe output of pace-making vector is closed, power management chip closes the power supply of pacemaking generation device, to close pace-making output.
In one embodiment, host computer sends initial pacemaker current to second processor, and second processor passes through serial portsFirst processor is transmitted to, starts pace-making, second processor is by the feedback sample pacemaker current signal of optocoupler, at firstReason device is directly sampled to pacemaker current signal.First processor and second processor are adopted with different resistance respectivelySample, the pacemaker current that first processor and second processor are sampled is contrasted, normal if both are consistent, if bothIt is inconsistent, stop pacing and sending failure code.Specifically, pacemaking generation device includes the first current sampling circuit and secondCurrent sampling circuit, the first current sampling circuit is connected with first processor, and the second current sampling circuit connects with second processorConnect, the pacemaker current for the second current sampling circuit sampling that second processor be sent can be received by first processor, compares theThe pacemaker current of the pacemaker current of one current sampling circuit and the second current sampling circuit, and export comparative result, when both oneDuring cause, it is failure to actuate；When both are inconsistent, first processor control pacemaker impulse sending module closes pacemaker impulse output, withStop pace-making；The pace-making electricity for the first current sampling circuit sampling that first processor is sent can also be received by second processorStream, compares the pacemaker current of the first current sampling circuit and the pacemaker current of the second current sampling circuit, and exports comparative result,When both are consistent, it is failure to actuate；When both are inconsistent, it is defeated that second processor control pace-making boost module stops pace-making vectorGo out, to stop pace-making.In addition, setting hardware comparator formation current foldback circuit on hardware, pacemaker current is judged,If excessively stream, the output of pacemaker impulse sending module is closed by the energizing signal of hardware comparator, stops pace-making output.
In one embodiment, pacemaking generation device also include isolation circuit, impedance detection module by isolation circuit withSecond processor is connected.Due to being related to the influence of high voltage and current impulse during pace-making, for reduction interference, it is ensured that impedanceThe accuracy of detection module, isolation circuit is powered with isolated form transformer.As shown in fig. 7, isolating transformer passes through LDO5V and 3.3V voltages are produced after the conversion of (Low Dropout Regulator, low pressure difference linear voltage regulator) change-over circuit for resistanceAnti- detection module is used, and impedance detection module one end is connected with pacing electrode, the impedance detection module other end and analog-digital converterConnection, second processor is sampled and controlled to analog-digital converter by Serial Peripheral Interface (SPI) through isolation circuit, and sampling is obtainedPace the impedance signal of object；And the impedance signal of pace-making object is sent to first processor, first processor by serial portsImpedance signal is made the following judgment：Predetermined threshold value of the obtained impedance value with setting that will sample is contrasted, when higher than defaultHighest threshold value when then think that electrode slice comes off, stop pacemaker impulse transmission, think electrode when less than default lowest thresholdPiece short circuit, stops the transmission of pacemaker impulse, if between highest threshold value and lowest threshold, then it is assumed that normal, sends pace-making arteries and veinsPunching.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned realityApply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not depositedIn contradiction, the scope of this specification record is all considered to be.
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneouslyCan not therefore it be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the artSay, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present inventionScope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.