A kind of bionical acetabular componentTechnical field
The present invention relates to a kind of medicine equipment, more particularly to a kind of bionical acetabular component.
Background technology
Replacement of Hip Joint is that clinic rebuilds the maximally efficient medical means of disease damage hip joint function at present, clinicallyObtain extensive use.Traditional acetabular component all includes the parts such as acetabular cup and liner, but its acetabular cup and liner installation sideFormula often to be directly placed into formula, does not carry out position and fixes, thus in use it is possible that loosening or displacement, have impact onProduct stability in use.Additionally, also existed as outer implant between implantation prosthese and tissue lack mass exchange,Biocompatibility is poor, is subject to rejection, and postoperation recovery effect on driving birds is not good, and connective stability is not strong, easily loosen,The general character defect such as rotate and come off.
Porous material has the characteristics such as relative density is low, specific strength is high, specific surface area is high, good penetrability, in chemical industry, medicineHad a wide range of applications Deng numerous areas.Wherein, multilevel hole material is due to its unique performance --- while having the excellent of holes at different levelsGesture, and there is the advantage not available for the material in single hole simultaneously, and receive much concern.For example, the macropore with three-dimensional orderThe molecular sieve of (aperture ＞ 50nm)-mesoporous (2nm ＜ apertures ＜ 50nm)-micropore (aperture ＜ 2nm) structure, with reference toMulti-stage artery structure and molecular sieve both advantages nanocrystalline, impart the more open three-dimensional open-framework of molecular sieve, whileNano molecular sieve crystal substantially reduces mass transfer path, is effectively improved materialization activity of gained molecular sieve etc..However,The multilevel hole material being applied in prosthetic replacement at present is extremely limited.This may be mainly due to existing porous material sheetBody can not have porosity and structural mechanics intensity higher concurrently, therefore, its porosity is generally relatively low, heavier, connectivity of conducting oneself with dignityIt is poor, it is unfavorable for the efficient exchange of material in tissue, biocompatibility is undesirable, postoperation recovery effect on driving birds is not good；Human bodyTissue can not cover with inside configuration, it is impossible to eliminate the reasons such as cell stress barrier.
Additionally, being applied to biomimetic artificial bone need material uniform in itself, such as pore size, hole are evenly distributed, to cause propertyEnergy uniformity, but in fact, there are many multilevel hole materials not reach the requirement；In spite of call oneself and reached high uniformity,But its uniformity is still the uniformity under large volume yardstick, if carrying out measurement comparing with small size yardstick, such as is taken up an official post in materialThe said three-dimensional body that polylith volume is not more than one cubic centimetre and formed objects is taken, its quality is surveyed respectively, its degree of irregularity difference is stillSo very big, the various performances for thus resulting in multilevel hole material are uneven, and such as pore size, space skewness result in powerThe uneven distributions such as intensity, elastic modelling quantity are learned, the defects such as hidden danger of quality is caused, so as to have a strong impact on its function.Such asCN201210185031 discloses a kind of preparation method of the biomimetic artificial bone of multistage (micrometer/nanometer) pore structure, but adoptsThe three-dimensional multistage pore structure obtained with the method, randomness, scrambling due to its pore structure still can not meet bionicalThe functional requirement of artificial bone.
The content of the invention
It is an object of the invention to provide a kind of bionical acetabular component, its structure stable connection is easily installed, and has concurrently higherBiocompatibility.
The purpose of the present invention is achieved through the following technical solutions：
A kind of bionical acetabular component, it includes acetabular cup and liner, it is characterised in that：The rim of a cup inner surface of the acetabular cupIt is provided with draw-in groove；Spring collar is had additional in the draw-in groove；It is placed with the liner in the acetabular cup, and the linerRim of a cup props up the lower surface of the spring collar；The acetabular cup is made of multilevel hole material.
To further facilitate installation, above-mentioned spring collar is set to two interruption annulars of journal stirrup.During installation, journal stirrup is pinchedFirmly, spring collar is cylindrical diminishes, and now spring collar can be put into draw-in groove；Journal stirrup, spring collar are decontroled after being put into againRestore to the original state, you can be installed in place, it is simple to operate, Same Way is used during taking-up.
To further facilitate operation, a breach is provided with the rim of a cup of above-mentioned acetabular cup；On the rim of a cup inner surface of above-mentioned acetabular cupDraw-in groove is in interruption annular；The breach that above-mentioned journal stirrup is stretched out at above-mentioned acetabular cup rim of a cup.
Used as further optimization, the above-mentioned multilevel hole material that above-mentioned acetabular cup is used specifically is made up of multistage porous material,Including material body, body is the vestibule being classified with material pore size, and is constituted around the cavity wall for forming vestibule, itsVestibule is in uniform distribution, and subordinate's vestibule is set in the cavity wall for constituting higher level's vestibule in three dimensions；Vestibules at different levels are eachFrom being mutually communicated and vestibule at different levels also insertion each other each other, vestibule refers to each vestibule on multilevel hole material in uniform distributionIt is in uniform distribution under arbitrary unit level volume.
More specifically, above-mentioned multilevel hole material, its intrinsic every grade of porous material is a continuous structure body certainly.
Above-mentioned multilevel hole material, the cavity wall of higher level's vestibule can be made up of next stage porous material, so that vestibule is layered step by step,And the structure and pore size of reasonable Arrangement vestibule；The cavity wall of higher level's vestibule can also be combined by the multistage porous material of its subordinateConstitute, to cause that material meets specific functional requirement.
Above-mentioned multilevel hole material, it is suitable with the space boundary of whole material body per the maximum external boundary of one-level porous material.The porous material that i.e. every grade porous material can serve as one-level independence is present in body, and with its physical and chemical performance alone.Such structure can cause the physical and chemical performance of porous materials at different levels difference, have in the whole space of relatively-stationary materialThere are different physical and chemical performances, preferably meet many functional requirements.
More specifically, above-mentioned unit level volume refers to cubic centimetre level or cubic millimeter level or more subsection level volume.
More specifically, above-mentioned vestibule refers to be not more than 1 cube in the take up an official post volume that takes of the multilevel hole material in uniform distributionThe said three-dimensional body of the formed objects of millimeter, their quality are substantially suitable.
Above-mentioned quality quite refers to be not more than 1 cubic millimeter of formed objects in take up an official post multiple volumes for taking of multilevel hole material substantiallySaid three-dimensional body, its quality is claimed respectively, obtain the average value of their quality, and any three-dimensional weight is relative to mass average valueAbsolute value of the bias be not more than the 4% of said three-dimensional body mass average value.
Above-mentioned multilevel hole material in the present invention, can be specifically made of conventional medical metal, alloy and the material such as nonmetallic.
The invention has the advantages that：
(1) the invention provides a kind of bionical acetabular component, it is set by the draw-in groove on acetabular cup rim of a cup inner surfaceSpring collar, is used to prop up liner, realizes and liner is secured firmly in acetabular cup, it is therefore prevented that in use it is possible thatDisplacement or loosening, it is ensured that product stability in use.And further set by journal stirrup, breach etc., simplify installation andTake out operation.
(2) its acetabular cup is integrally made of multilevel hole material；The multilevel hole material is three-dimensional insertion (including every grade of holeThree-dimensional insertion, holes at different levels three-dimensional insertion mutually), its connectivity is greatly improved, and fully meets material as bionicalVarious functional requirements of artificial bone, for example, having good structural mechanical property and porosity higher concurrently, greatly alleviateDead load, enhances the efficient exchange of material in implantation Periprosthetic tissue, greatly accelerates the convalescence after Miles operation.AndBefore implantation the phase increase the contact area between structure and tissue, increase adhesive force；And phase, its vestibule after the implantationConstitute, the multistage space of approximating anatomy's Tissue distribution structure, good sky is grown into for the fast-growth of tissue is providedBetween so that tissue in order, selectively enter spaces at different levels, and then form multistage and grow into robust structure, both kept awayExempt to set stable connection structure on acetabular cup again, and greatly improved the connective stability of structure, also greatly reducedThe rejection of human body, and the bad impression that thus brings, its healing effect is more preferably faster.
(3) also the vestibule of multilevel hole material is evenly distributed in the present invention and proposes the metric form of specific, concrete, specify thatIt is the pore size distribution uniformity that multilevel hole material is measured under compared with the yardstick of subsection level volume, such multilevel hole material is highDegree is uniform, so as to ensure that the uniformity consistency of the various performances of multilevel hole material, it is to avoid the internal flaw of selection.
Brief description of the drawings
Fig. 1 is the structural representation of bionical acetabular component described in the embodiment of the present invention 1.
Fig. 2 is the A-A sectional views of bionical acetabular component described in Fig. 1.
Fig. 3 is the upward view of bionical acetabular component described in Fig. 2.
Fig. 4 is the structural representation of bionical acetabular component described in the embodiment of the present invention 2.
Specific embodiment
Premised on technical solution of the present invention, its detailed implementation method is following present, but protection scope of the present invention is not onlyIt is limited to embodiment disclosed below.In the case of not departing from and changing above-mentioned technological thought of the invention, according to the common skill of this areaArt knowledge and/or customary means, it is clear that the replacement or change of diversified forms can also be made, and model of the invention all should be included inWithin enclosing.
Embodiment 1
As shown in Figure of description 1-3, a kind of bionical acetabular component, it includes acetabular cup 1, liner 2 and spring collar 3；A breach 5 is provided with the rim of a cup of its acetabular cup 1, and the rim of a cup inner surface of acetabular cup 1 is provided with the annular draw-in groove 4 of interruption；Spring collar 3 is provided with draw-in groove 4；The spring collar 3 is set to be stretched out with two interruption annulars of journal stirrup 6, and journal stirrup 6Breach 5 at the rim of a cup of acetabular cup 1；Liner 2 is placed with acetabular cup 1, and the rim of a cup of liner 2 props up spring collar 3Lower surface；Its acetabular cup 1 is made of multilevel hole material；Multilevel hole material in this example is porous tantalum, and it has three-level hole,Wherein, there is the second level vestibule for being uniformly distributed, being mutually communicated in the cavity wall of the first order vestibule be uniformly distributed, being mutually communicated,There is the third level vestibule for being uniformly distributed, being mutually communicated in the cavity wall of second level vestibule；And vestibules at different levels also insertion each other each other,Described insertion is three-dimensional insertion；Every grade of porous material is a continuous structure body certainly, per the maximum external boundary of one-level porous materialSuitable with whole material body space boundary, every grade of porous material is with physical and chemical performance alone.Total effective drainage porosity is 80%,First order hole average pore size is 510 μm, there is the second level hole of the insertion of 25 μm of average pore size in the cavity wall in first order hole,There is the third level hole of average pore size 780nm insertions in the cavity wall in second level hole.
Taken up an official post in the multilevel hole material with conventional machining method and take 9 the three of the same size of 10mm × 10mm × 10mmDimension body, its quality is tested with plum Teller-support benefit XP26Microbalance balances, as a result as shown in table 1, wherein, phaseAbsolute value of the bias for average value is expressed as a percentage, and its value is average divided by quality relative to the absolute value of the bias of average valueValue, as shown in Table 1, its mass deviation is not more than 4%.
Table 1
| Piece number | Quality (mg) | Relative to the absolute value of the bias (%) of average value |
| 1 | 3282.624 | 1.6% |
| 2 | 3292.63 | 1.3% |
| 3 | 3242.592 | 2.8% |
| 4 | 3265.944 | 2.1% |
| 5 | 3285.960 | 1.5% |
| 6 | 3469.440 | 4% |
| 7 | 3409.392 | 2.2% |
| 8 | 3396.048 | 1.8% |
| 9 | 3379.368 | 1.3% |
| Mass average value | 3336 | |
The preparation method of this kind of material is：
(1) material prepares
It is the polystyrene sphere of 900 ± 30nm to choose particle diameter, is assembled the colloid template to form three-dimensional order arrangement, systemStandby tantalum nanocrystal solution, tantalum nanocrystal solution is introduced into the three-dimensional colloid template that polystyrene sphere is made, by three-dimensional colloidThe mixture of template/tantalum nanocrystal solution is dried, and is then broken for the particle that particle diameter is 5 μm；
(2) starch that particle diameter is 900 ± 30nm is taken, is mixed with distilled water according to part by weight 1: 40, be made starch moltenLiquid, slurry is made by ethyl cellulose that above-mentioned particle, particle diameter are 35 μm and starch solution according to part by weight 12: 1: 8,It is uniformly impregnated with to aperture as on 600 ± 20 μm of polyester form；
(3) polyester form after dipping is sintered in vacuum or protective atmosphere, conventional follow-up place is carried out according still further to tantalum techniqueReason, is obtained the porous tantalum with three-level hole.
Used as bone-regeneration material, first order hole size is particularly suitable for meeting the demand that the vital tissues such as blood vessel grow into this kind of porous tantalum；Second level hole is particularly suitable for living away from home for various kinds of cell；Third level hole is particularly conducive to meet cell because of its substantial amounts of nano-poreStick, differentiation demand, and specific surface area is very big, can load many growth factors, and the adhesive force organized between bone is also stronger,And, the connectivity in hole is good, and holes at different levels are each mutually communicated and hole at different levels also insertion each other each other, can fully meet bloodLiquid, the infiltration of tissue fluid, transmission, realize the discharge of protein degradation products and metabolism product, therefore it is a kind of truePositive bone-regeneration material.
During using installing, first journal stirrup 6 is pinched, spring collar 3 is cylindrical to diminish, and now spring collar 3 can be put into cardIn groove 4；Journal stirrup 6 is decontroled after being put into again, spring collar 3 restores to the original state, you can be installed in place, simple to operate, takesSame Way is used when going out.
Embodiment 2
As shown in Figure of description 4, a kind of bionical acetabular component, it includes acetabular cup 1, liner 2 and spring collar 3；The rim of a cup inner surface of its acetabular cup 1 is provided with an annular slot；Spring collar 3 is provided with draw-in groove；The spring collar 3 is set toWith two interruption annulars of journal stirrup 6；Liner 2 is placed with acetabular cup 1, and the rim of a cup of liner 2 props up spring collar 3Lower surface；Its acetabular cup 1 is made of multilevel hole material；Multilevel hole material in this example is POROUS TITANIUM, and it has three-levelHole, wherein, there is the second level hole for being uniformly distributed, being mutually communicated in the cavity wall of the first order vestibule be uniformly distributed, being mutually communicated, there is the third level vestibule for being uniformly distributed, being mutually communicated in chamber in the cavity wall of second level vestibule；And vestibules at different levels are each other also each otherInsertion, described insertion is three-dimensional insertion.Every grade of porous material is a continuous structure body certainly, per the maximum of one-level porous materialExternal boundary is suitable with whole material body space boundary, and every grade of porous material is with physical and chemical performance alone.Total effective drainage porosityIt is 75%, first order hole average pore size is 450 μm, have the insertion of 30 μm of average pore size in the cavity wall in first order hole theSecond hole, the third level hole for having the insertion of average pore size 670nm in the cavity wall in second level hole.
Taken up an official post in the POROUS TITANIUM with conventional machining method and take 9 said three-dimensional bodies of the same size of 10mm × 10mm × 10mm,Its quality is tested with plum Teller-support benefit XP26 Microbalance balances, as a result as shown in table 2, wherein, relative to flatThe absolute value of the bias of average is expressed as a percentage, its value be the absolute value of the bias relative to average value divided by mass average value, byTable 2 understands that its mass deviation is not more than 4%.
Table 2
| Piece number | Quality (mg) | Relative to the absolute value of the bias (%) of average value |
| 1 | 1156.184 | 1.4% |
| 2 | 1135.077 | 3.2% |
| 3 | 1151.493 | 1.8% |
| 4 | 1157.356 | 1.3% |
| 5 | 1145.630 | 2.3% |
| 6 | 1217.159 | 3.8% |
| 7 | 1197.225 | 2.1% |
| 8 | 1191.362 | 1.6% |
| 9 | 1201.915 | 2.5% |
| Mass average value | 1172.600 | |
The preparation method of this kind of POROUS TITANIUM is：
(1) material prepares
It is raw material for 2 μm of titanium valve to use particle diameter, and particle diameter is the minimum one-level of the starch as multilevel hole material to be made of 770nmThe pore creating material of vestibule, with the stearic acid that particle diameter is 770nm as adhesive, according to titanium valve: starch: stearic acid: distilled waterIt is configured to slurry at 3: 1: 1: 11 by volume.
Using a diameter of 30 μm of polyester form of rib, by the slurry, with foam impregnation method, uniformly filling wherein, forms base substrateAnd dry, then crush and obtain the hybrid particles containing raw material, pore creating material and polyester form that particle is 30 μm.
(2) will equably be poured into after methylcellulose that hybrid particles, particle diameter are 30 μm by volume 3: 1 uniform mixingDuring a diameter of 560 ± 20 μm of rib, aperture are for the polyester form of 400 ± 15 μm of three-dimensional insertion, then polyester form is put intoClosed mold is pressed into dense green.
(3) by dense green vacuum-sintering；Base substrate after sintering carries out conventional subsequent heat treatment according to titanium technique to be hadThere is the POROUS TITANIUM in three-level hole.
Similar to embodiment 1, this kind of material is particularly suitable for doing bone-regeneration material.