A kind of stimulus generatorTechnical field
The present invention relates to medical instruments field, in particular it relates to a kind of stimulus generator.
Background technology
Traditional cardiac stimulation system provides elicited by direct current pulse cardiac muscle using stimulating electrode as negative electrode, and electric current is from the moonPole is flowed out, and anode is flowed into after tissue, body fluid, forms loop.For this using fixed cathode electrode and direct currentPulse paces the mode of heart tissue, can inevitably form polarization potential in electrode head end, produces polarization impedance, influence thornSwash threshold values.In the electrode using the small surface area of high impedance, polarization impedance can reach more than the 70% of whole system impedance, makeSystem pace-making efficiency reduction, the battery of pacemaker is easily exhausted.Meanwhile, Unidirectional direct-current pulse causes tissue reactive to increase, fineDimensionization degree increases, and have impact on the long-time stability of stimulation parameter.
In view of this, how further to improve stimulus generator, improving stimulates efficiency, reduction be stimulated tissue reactive andExtend the battery life of stimulus generator, be that this area has technology to be solved to overcome the defect of above-mentioned traditional stimulating systemProblem.
The content of the invention
It is an object of the invention to provide a kind of stimulus generator, it is it is critical that improve stimulus generator grantingThe pattern of boost pulse, reduces the polarization impedance of excitable tissue, reduces the battery of stimulus threshold and extension stimulus generatorLife-span；It is compared with conventional pacemaker, increased the position of the application of anode pace-making and pace-making.
The present invention is adopted the technical scheme that：
The invention provides a kind of stimulus generator.The stimulus generator includes at least two impulse output circuits and at least oneControl circuit is perceived, each electric stimulation pulse that the impulse output circuit is exported is single-phase ripple, is showed during alternate changeIt is two single-phase and in opposite direction boost pulses；The control circuit that perceives is stimulated the level signal of body for perceiving and controlsImpulse output circuit processed sends pulse signal to the stimulating electrode.
Preferably, the electric stimulation pulse of the impulse output circuit is connected to stimulating electrode by triode and lead,The control circuit that perceives is located between triode and stimulating electrode while being also electrically connected with the impulse output circuit respectively.
Preferably, the pulse signal output end of the impulse output circuit connects the base stage of the triode, triodeEmitter stage the stimulating electrode is connected by lead.This case triode preferentially uses NPN type triode.
Preferably, the control circuit that perceives includes perceiving unit and control unit, the perception unit is used for real-timeReceiving is stimulated the perception electrocardiosignal of body, and is sent to control unit, and control unit detects the effective of the electrocardiosignalProperty, and impulse output circuit sends polarity pulse signal to stimulating electrode according to the Polarity Control of the electrocardiosignal.
Preferably, multiple stimulating electrodes can be derived on the stimulating electrode, positioned at multiple stimulating electrodes of same one endIt is parallel with one another, to realize multipole reversal.
This stimulus generator can connect traditional monopole electrode, thus change conventional method using lead distal end electrode fix asNegative electrode and the fixation of pacemaker shell as anode stimulation mode, traditional monopolar electrode can pierce alternately as negative electrode or anodeSwash cardiac muscle.
This stimulus generator can also be connected with traditional bipolar electrode, thus change conventional method and fix remote electrodeAs negative electrode and annular electrode fixation as anode stimulation mode, remote electrode and annular electrode can alternately as negative electrode orAnode excitation cardiac muscle.
This stimulus generator can be also used for the heart intramuscular electrode independent with two and be connected, and make this two electrodes only respectivelyIt is vertical to provide boost pulse, or boost pulse is provided respectively as negative electrode and anode joint, meanwhile, polarity of electrode can alternately becomeChange.
Preferably, the stimulus generator that the present invention is provided includes：Double pulse generator, referred to as " double-core " stimulus generator,Referred to as " double-core " pacemaker when being used in heart；And/or multipulse generator（≤ 3 impulse generators）Associated workingPattern, referred to as " multinuclear " stimulus generator, referred to as " multinuclear " pacemaker when being used in heart.Described stimulus generatorImpulse stimulation electric current in opposite direction alternately can be provided, be equal to negative electrode and anode polarity alternate change.Described stimulation hairThe component connection circuit of raw device includes the connection circuit of any mode of pulse-pair output circuit or multiple-pulse output circuit.
Special instruction, the stimulus generator and Patent No. US4402322-A of present invention offer,The stimulus generator that JP2001190695-A with US6341235 B1 are provided is different.Patent No. US4402322-A,It is by two phase waves that the stimulus generator that JP2001190695-A and US6341235 B1 are provided sends out impulse stimulation（two-Phase or biphase）The single boost pulse for constituting, its first phase and the second phase wave form, wave amplitude, time are different.AndStimulus generator of the present invention sends out each impulse stimulation and is single-phase rectangular wave, and two single and directions are shown as during alternate changeDifferent boost pulses, pulsewidth and amplitude can be adjusted through program controller.
The stimulus generator that the present invention is provided alternately is provided electric pulse in opposite direction and is meant：Interval is certain or not etc.Number of times or interval is certain or after time that do not wait, the electric pulse of granting different directions.
The stimulus generator sends out impulse stimulation and is single-phase, and feature includes showing as direction during alternate change different.
" double-core " and " multinuclear " stimulus generator or pacemaker that the present invention is provided, its function should not be understood merely as providingBoost pulse, should also include：Perceptional function, diagnostic function and defibrillating function.
A kind of new electric stimulation pulse mode and/or " double-core " or " multinuclear " stimulus generator of present invention offer/Or pacemaker：Preferably used in heart as one kind, but be not limited to heart, it is understood that being applicable outside any heart needs electricityThe tissue for stimulating and/or perceiving, such as：Blood vessel, brain and peripheral nerve etc..
The stimulus generator that the present invention is provided has following advantage compared with prior art：
The stimulus generator that the present invention is provided alternately can provide pulse current in opposite direction, and this is one kind that the present invention is providedBrand-new electric stimulation pulse mode.Compared with one direction boost pulse, the stimulation of this checker pulse direction can be significantlyDegree reduces the histio-irritative adverse reaction of institute, reduces tissue polarity current potential and polarization impedance, reduces stimulus threshold, while convenientImplement the threshold value autocapture function of stimulus generator, make the longer cell life of stimulus generator.
Brief description of the drawings
Accompanying drawing is, for providing a further understanding of the present invention, and to constitute the part of specification, with following toolBody implementation method is used to explain the present invention together, but is not construed as limiting the invention.
Fig. 1 is the structure and operation principle block diagram of stimulus generator of the invention.
Fig. 2 is one kind " double-core " stimulus generator circuit catenation principle figure that the present invention is provided.
Specific embodiment
The present invention is described in detail with specific embodiment below in conjunction with the accompanying drawings.
Embodiment one.
As shown in figure 1, first aspect present invention provides a kind of stimulus generator, it includes at least two boost pulseOutput unit, at least one perceives and control unit.Such as Fig. 2, the pulse signal output end of the boost pulse output circuit leads toCross triode and lead is connected to the stimulating electrode, the perception control circuit is located between triode and stimulating electrode simultaneouslyAlso there is circuit with the boost pulse respectively to be electrically connected with, perceiving control circuit is used to perceive the level signal for being stimulated body simultaneouslyPulse signal is sent there is circuit to the stimulating electrode in control boost pulse.
One kind as the present embodiment is preferred, and the boost pulse occurs the pulse signal output end connection described three of circuitThe base stage of pole pipe, the emitter stage of triode connects the stimulating electrode by lead.The control circuit that perceives includes perceiving listUnit and control unit, the perception unit are used for receiving in real time and are stimulated the perception electrocardiosignal of body, and are sent to controlUnit, control unit detects the validity of the electrocardiosignal, and the boost pulse hair according to the Polarity Control of the electrocardiosignalRaw circuit sends polarity pulse signal to stimulating electrode.As shown in Fig. 2 multiple stimulation electricity can be derived on the stimulating electrodePole, the multiple stimulating electrodes positioned at same one end are parallel with one another, to realize multistage reversal.
Two boost pulse output circuits form double pulse generator associated working pattern, and referred to as " double-core " stimulation occursDevice, referred to as " double-core " pacemaker when being used in heart；And/or multipulse generator（≤ 3 impulse generators）Associated workingPattern, referred to as " multinuclear " stimulus generator, referred to as " multinuclear " pacemaker when being used in heart；The feature of the stimulus generatorIncluding：Pulse current in opposite direction can be alternately provided, i.e. boost pulse is provided in alternating polarity conversion.
Component connection circuit included by the stimulus generator that the present invention is provided should not be only understood shown in Fig. 2, it should managedSolution is the connection circuit of any mode for including pulse-pair output circuit or multiple-pulse output circuit.
The stimulus generator that the present invention is provided alternately is provided electric pulse in opposite direction and is meant：Interval is certain or not etc.Number of times or interval is certain or after time that do not wait, the electric pulse of granting different directions.
The stimulus generator sends out impulse stimulation and is single-phase, and feature includes showing as direction during alternate change different.
" double-core " and " multinuclear " stimulus generator or pacemaker that the present invention is provided, its function should not be understood merely as providingBoost pulse, should also include：Perceptional function, diagnostic function and defibrillating function.
A kind of new electric stimulation pulse mode and/or " double-core " or " multinuclear " stimulus generator of present invention offer/Or pacemaker：Preferably used in heart as one kind, but be not limited to heart, it is understood that being applicable outside any heart needs electricityThe tissue for stimulating and/or perceiving, such as：Blood vessel, brain and peripheral nerve etc..
The basic principles, principal features and advantages of the present invention have been shown and described above.One of ordinary skill in the artIt should be appreciated that the mode such as above-described embodiment protection domain that the invention is not limited in any way, all use equivalents is obtainedThe technical scheme for obtaining, falls within protection scope of the present invention.
Part that the present invention does not relate to is same as the prior art or can be realized using prior art.