A kind of valve and preparation method thereofTechnical field
The present invention relates to heart valve fields, more particularly to a kind of valve and preparation method thereof.
Background technique
The artificial valve of clinical use has two major classes at present, first is that mechanical prosthetic valve, main to be made by pyrolytic carbon.With St-Jude Medical and Carbomedics mechanical prosthetic valve is representative.Its main feature is that long service life, but its leaflet is rigid leaflet sheetStructure, leaflet folding sound is larger, because of blood compatibility reason, needs lifelong Anticoagulation of Warfarin, thrombosis and bleedingRisk seriously affects therapeutic effect and patients ' life quality.Second is that biovalve, using valve made of cattle pericardium and porcine aortic valve as representative.It is good with haemodynamics, it is not required to long-term anticoagulant advantage, but its calcification in vivo, decay, keeps its service life shorter, it is moreNumber is adapted only to gerontal patient.
Summary of the invention
In view of the above drawbacks of the prior art and problem, the purpose of the embodiment of the present invention is that provide a kind of long service life andThe good valve of antithrombotic effect.
In order to achieve the above object, the invention provides the following technical scheme: a kind of valve preparation method, including, it is following to walkIt is rapid:
S1: cylindrical die is soaked in polyurethane solutions, using Best-Effort request coating method on cylindrical die surfacePrepare polyurethane inner membrance；
S2: taking valve bracket, and the outer surface that valve bracket is set in polyurethane inner membrance is obtained prefabricated valve semi-finished product, willPrefabricated valve semi-finished product are soaked in polyurethane solutions, are coated and are gathered in prefabricated valve surface of semi-finished using Best-Effort request coating methodUrethane outer membrane；Demoulding, obtains prefabricated valve；
S3: moulding is arranged to prefabricated valve, obtains valve finished product.
Wherein, the step S3 includes:
S301: prefabricated valve includes support portion and polyurethane film portion, by the extra polyurethane film at the outlet end of support portionExcision, the polyurethane film at support portion liquid inlet is inwardly overturn, and is stretched out from the outlet end of support portion, extending area forms annularOpen leaflet；
S302: the circumference trisection point of ring-shape open leaflet end is fixed on support portion by the stickup of 5%THF solutionOutlet end makes it be consistent with human heart valve closed state shape, obtains valve semi-finished product；
S303: valve semi-finished product are placed in 80-90 DEG C of drying box, keep the temperature 8-12 hours, obtain valve finished product.
Wherein, the step S2 includes:
Step using Best-Effort request coating method prefabricated valve surface of semi-finished coat polyurethane outer membrane after, further include asLower step:
S201: taking reinforcing rib, and reinforcing rib is pasted on support portion by binder, uses Best-Effort request coating method support portionSurface forms reinforcing rib polyurethane outer membrane.
Wherein, the polyurethane solutions mass concentration is 5-30%.
Wherein, the polyurethane solutions the preparation method comprises the following steps: by PU grain dissolution into THF solution, stir evenly, and quietSet 1-2h.
Wherein, the material of the bracket is selected as stainless steel.
A kind of valve, including the poly- ammonia including annular frame support portion and leaflet portion obtained by tubular polyurethane film mouldingEster valve further includes ring support, and the ring support is embedded in the annular frame support portion of the polyurethane valve.
Wherein, the tubular polyurethane film is coated on the ring support surface, from the liquid inlet of the ring support toOuter extension；The extension of tubular polyurethane film is to overturning inside the ring support, extreme circumferential trisection point and the annularThe outlet end of bracket is fixedly connected.
Wherein, reinforcing rib is arranged in the ring support surface.
Wherein, the ring support surface is smooth mirror surface.
The valve as prepared by this method, so that leaflet and bracket are integrally formed, has higher by impregnating lifting moldingService life, bracket is not good with contacting blood antithrombotic effect, and valve can be obtained opening area in the production process, guaranteeSufficient opening area and the disqualification rate for reducing finished product, while there is production technology step is simple compared with the existing technology, it canControl property is stronger, conducive to the batch production of valve.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show belowThere is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only thisSome embodiments of invention without any creative labor, may be used also for those of ordinary skill in the artTo obtain other drawings based on these drawings.
Fig. 1 is perspective view of the invention；
Fig. 2 is top view of the invention.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear thatDescribed embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the implementation in the present inventionExample, every other embodiment obtained by those of ordinary skill in the art without making creative efforts belong toThe scope of protection of the invention.
As embodiment, a kind of valve preparation method takes cylindrical die, and the diameter of cylindrical die is less than valve bracketDiameter, diameter are selected as 10-30mm, range needed for covering is clinical.The material of cylindrical die is preferably stainless steel, and surface polishing is extremelyMirror surface, seamless and corner angle.Using Best-Effort request coating method, cylindrical die is soaked in polyurethane solutions, impregnates 10 pointsClock, by cylindrical die with 2.5 × 10-3M/s is at the uniform velocity lifted, to prepare polyurethane inner membrance on cylindrical die surface.Wherein,The mass concentration of polyurethane solutions be 5-30%, preferably 15%.Preparation method be by PU grain dissolution into THF solution,It stirs evenly, and stands 1-2h.Preferably, PU grain dissolution is stirred evenly into THF solution, stands 1.5 hours.Take valveMembrane support, valve bracket are ring support, and the both ends of valve bracket are respectively the liquid inlet entered for blood stream and go out for blood streamOutlet end, valve bracket is set in film outer surface in polyurethane, the polyurethane inner membrance outside the liquid inlet of valve bracketLength is longer than the length of valve bracket.Prefabricated valve semi-finished product are obtained after the completion of suit.It, will be prefabricated using Best-Effort request coating methodValve semi-finished product are soaked in polyurethane solutions, are impregnated 5 minutes, by cylindrical die with 2.5 × 10-3M/s is at the uniform velocity lifted, thusPolyurethane outer membrane is coated in prefabricated valve surface of semi-finished.In valve bracket is coated on by polyurethane outer membrane and polyurethane inner membrance,Keep valve bracket not exposed, avoid directly contacting with blood, promotes antithrombotic property, prolong the service life.Polyurethane film andValve bracket from cylindrical die get under, demoulding, obtain prefabricated valve.Moulding is arranged to prefabricated valve, forms human heart valveFilm shape.To obtain valve finished product.
Arrange the specific steps of moulding are as follows:
Valve bracket position is support portion in prefabricated valve, remaining position is polyurethane film portion, by entering for support portionPolyurethane film excision at liquid end, will avoid valve bracket is exposed during excision.By the polyurethane at support portion liquid inletFilm is turned inside out to support portion, and is stretched out from the outlet end of support portion, and extending area is trimmed, and extending area is made to be higher than branchThe outlet end 10-30mm of support part.Extending area forms cyclic annular open leaflet, and the diameter of the open leaflet of ring-type is that theoretically valve is openedMaximum gauge is put, the openings of sizes of valve can be measured in the process, substandard product is filtered out, reduces finished product notQualification rate, and valve orifice size can get and accurately measure.By the end of ring-shape open leaflet, circumference trisection point passes through5%THF solution pastes the outlet end for being fixed on support portion, it is made to be consistent with human heart valve closed state shape, obtains valveSemi-finished product.Valve semi-finished product are placed in 80-90 DEG C of drying box, preferably 80 DEG C, keep the temperature 8-12 hour, acquisition valve atProduct.
In one embodiment, prefabricated valve can also be reinforced by reinforcing rib, improve the service life of valve.Reinforcing sideFormula is to take reinforcing rib, and reinforcing rib is pasted on support portion by binder, and binder is selected as existing binder, preferably,THF solution.The prefabricated valve for having reinforced reinforcing rib is soaked in polyurethane solutions using Best-Effort request coating method, in support portionSurface forms reinforcing rib polyurethane outer membrane.
Leaflet thickness is determined by soaking time, number, can is 0.02mm to 2mm, be depended on different parts valve to leafletThe requirement of across valve pressure, pliability, intensity.Valve sinus portion refers to the part between annular leaflet and bracket, made by the present inventionLeaflet pliability is high, open abundant, blood can sufficiently be squeezed out to sinus portion when open, blood is not easy to stop gathering in sinus portion, is not easy shapeAt thrombus.
Preferably, the outlet end of ring support is crown-shaped.
According to Fig. 1-2, a kind of valve, as made by the above method, including what is obtained by tubular polyurethane film mouldingPolyurethane valve including annular frame support portion and leaflet portion, further includes ring support 2, and the ring support 2 is embedded in instituteIt states in the annular frame support portion of polyurethane valve 1.Wherein, the tubular polyurethane film is coated on the ring support surface,Extend outwardly from the liquid inlet of the ring support；The extension of tubular polyurethane film is to overturning inside the ring support, endEnd circumference trisection point 3 is fixedly connected with the outlet end of the ring support.Wherein, the ring support surface setting is reinforcedMuscle.Wherein, the ring support surface is smooth mirror surface.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, anyThose familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all containLid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.