技术领域technical field
本发明涉及成像领域，尤其涉及一种光声探头及光声成像系统。The invention relates to the field of imaging, in particular to a photoacoustic probe and a photoacoustic imaging system.
背景技术Background technique
光声成像是兼具光学成像高敏感性与超声成像深度优势的新型成像手段。与光学成像不同，光声成像检测的是光声效应产生的超声波，即脉冲激光束照射目标区域并被吸收，这将导致目标区域瞬时温度上升，随后产生热弹性膨胀的超声波，然后通过采集超声波信号重建图像反映物质的光学吸收特性。光学技术成像在分辨率等方面具有很大优势。同时超声波在生物组织的传播衰减远小于光信号，具有更深的成像深度；因此光声成像同时具有光学分辨率和声学成像深度的优点。此外，光声成像还具有无电离辐射、可实时扫描等其他分子成像技术不具备的优势；光声成像技术已被证明适用于经直肠的卵巢癌检测。光在近红外区域的吸收与血红蛋白含量直接相关，而癌细胞会引发复杂血管的快速生长，这使得光声成像成为检测肿瘤血管的优秀工具。近些年有研究尝试在现有超声成像设备的经直肠阵列式内窥超声探头的基础上直接进行光耦合，其优点在于能够充分利用原有超声探头的易操纵性，得到的光声图像也能够与超声图像自动重合匹配，实现多模成像的目的。但这一设计的主要难点在于，在不显著增加原有的超声探头尺寸的情况下，如何将光简单高效地传递到目标组织部位，并使光在组织上的照射区域和超声探头的探测区域重合，得到高质量的光声图像。Photoacoustic imaging is a new imaging method that combines the advantages of high sensitivity of optical imaging and depth of ultrasound imaging. Different from optical imaging, photoacoustic imaging detects ultrasonic waves generated by the photoacoustic effect, that is, pulsed laser beams irradiate the target area and are absorbed, which will cause an instantaneous temperature rise in the target area, and then generate ultrasonic waves that expand thermoelastically, and then collect ultrasonic waves The reconstructed image of the signal reflects the optical absorption properties of the substance. Optical technology imaging has great advantages in terms of resolution and so on. At the same time, the propagation attenuation of ultrasonic waves in biological tissues is much smaller than that of optical signals, and has a deeper imaging depth; therefore, photoacoustic imaging has the advantages of both optical resolution and acoustic imaging depth. In addition, photoacoustic imaging has advantages that other molecular imaging technologies do not have, such as no ionizing radiation and real-time scanning; photoacoustic imaging technology has been proven to be suitable for transrectal ovarian cancer detection. The absorption of light in the near-infrared region is directly related to the hemoglobin content, and cancer cells induce rapid growth of complex blood vessels, making photoacoustic imaging an excellent tool for detecting tumor blood vessels. In recent years, some studies have tried to directly perform optical coupling on the basis of the transrectal array endoscopic ultrasound probe of the existing ultrasound imaging equipment. It can be automatically overlapped and matched with ultrasound images to achieve the purpose of multi-mode imaging. However, the main difficulty of this design lies in how to transmit light to the target tissue in a simple and efficient manner without significantly increasing the size of the original ultrasound probe, so that the irradiation area of the light on the tissue and the detection area of the ultrasound probe Coincidentally, a high-quality photoacoustic image is obtained.
当前的光声内窥成像系统中，其激光照射部分与超声探头110的耦合设计主要是：从激光器出射的脉冲光被耦合进入四根光纤120，如图1所示，光声探头包括超声探头110、光纤120和铝箔130，所述光纤120分别被绑定到超声探头110四周，经过超声探头110外表面的铝箔130以及光声探头内表面的铝箔130进行漫反射，使激光发散照射到样本140表面，并在超声探头110正下方一定深度汇聚。由于光纤120中出来的激光仅靠铝箔130反射到超声探头下方，激光照射在样本表面时光发散不完全，其照射区域与超声探头探测区域的重叠面积小于探测区域面积的10％，从而难以激发出足够强的光声信号，从而造成成像效果不理想。In the current photoacoustic endoscopic imaging system, the coupling design of the laser irradiation part and the ultrasonic probe 110 is mainly: the pulsed light emitted from the laser is coupled into four optical fibers 120, as shown in Figure 1, the photoacoustic probe includes an ultrasonic probe 110. An optical fiber 120 and an aluminum foil 130. The optical fiber 120 is respectively bound to the surroundings of the ultrasonic probe 110, and undergoes diffuse reflection through the aluminum foil 130 on the outer surface of the ultrasonic probe 110 and the aluminum foil 130 on the inner surface of the photoacoustic probe, so that the laser beam diverges and irradiates the sample 140 surface, and converge at a certain depth right below the ultrasound probe 110. Since the laser light coming out of the optical fiber 120 is only reflected by the aluminum foil 130 to the bottom of the ultrasonic probe, the light divergence of the laser light on the sample surface is not complete, and the overlapping area of the irradiation area and the detection area of the ultrasonic probe is less than 10% of the detection area, so it is difficult to excite The photoacoustic signal is strong enough, resulting in unsatisfactory imaging effect.
发明内容Contents of the invention
本发明实施例所要解决的技术问题在于，提供一种光声探头及光声成像系统，成像效果较理想。The technical problem to be solved by the embodiments of the present invention is to provide a photoacoustic probe and a photoacoustic imaging system with ideal imaging effects.
为了解决上述技术问题，本发明第一方面一实施例提供了一种光声探头，包括：In order to solve the above technical problems, an embodiment of the first aspect of the present invention provides a photoacoustic probe, including:
超声探头，其用于探测样本发出的光声信号；an ultrasonic probe for detecting photoacoustic signals emitted by the sample;
光纤束，其包括第一光纤束和第二光纤束，该两个光纤束分别位于超声探头的相对两外侧，第一光纤束和第二光纤束用于传输激光；An optical fiber bundle, which includes a first optical fiber bundle and a second optical fiber bundle, the two optical fiber bundles are respectively located on the opposite two outer sides of the ultrasonic probe, and the first optical fiber bundle and the second optical fiber bundle are used to transmit laser light;
反射装置，其位于第一光纤束末端和第二光纤束末端的延长线上，所述反射装置倾斜设置，且所述反射装置的中心轴靠近光纤束的一端距离超声探头中心轴的距离大于反射装置的中心轴远离光纤束的一端距离超声探头中心轴的距离，所述反射装置用于将第一光纤束和第二光纤束出射的激光反射向样本上，且所述反射装置用于使第一激光束和第二激光束出射的激光在样本表面的照射区域与超声探头的探测区域的重叠面积大于探测区域面积的30％。Reflecting device, which is located on the extension line of the end of the first optical fiber bundle and the end of the second optical fiber bundle, the reflecting device is arranged obliquely, and the distance between the central axis of the reflecting device and the end of the ultrasonic probe central axis close to the optical fiber bundle is greater than that of the reflecting device The central axis of the device is far away from the distance between the end of the optical fiber bundle and the central axis of the ultrasonic probe. The reflecting device is used to reflect the laser light emitted by the first optical fiber bundle and the second optical fiber bundle to the sample, and the reflecting device is used to make the first optical fiber bundle The overlapping area of the irradiation area of the laser beam emitted by the first laser beam and the second laser beam on the sample surface and the detection area of the ultrasonic probe is greater than 30% of the area of the detection area.
在本发明一实施例中，所述第一光纤束和第二光纤束靠近反射装置一端的厚度小于远离反射装置一端的厚度。In an embodiment of the present invention, the thickness of the end of the first optical fiber bundle and the second optical fiber bundle near the reflecting device is smaller than the thickness of the end away from the reflecting device.
在本发明一实施例中，所述第一光纤束和第二光纤束靠近反射装置一端为扁平状。In an embodiment of the present invention, the ends of the first fiber bundle and the second fiber bundle near the reflection device are flat.
在本发明一实施例中，所述第一光纤束与超声探头末端的距离范围为5-15mm；所述第二光纤束与超声探头末端的距离范围为5-15mm。In an embodiment of the present invention, the distance between the first optical fiber bundle and the end of the ultrasonic probe is in the range of 5-15 mm; the distance between the second optical fiber bundle and the end of the ultrasonic probe is in the range of 5-15 mm.
在本发明一实施例中，所述超声探头呈U型，所述第一光纤束和所述第二光纤束分别位于U型超声探头的扁平区域。In an embodiment of the present invention, the ultrasonic probe is U-shaped, and the first optical fiber bundle and the second optical fiber bundle are respectively located in the flat area of the U-shaped ultrasonic probe.
在本发明一实施例中，还包括夹持件，所述第一光纤束、第二光纤束和所述反射装置通过夹持件安装在超声探头上。In an embodiment of the present invention, a clamping part is also included, and the first optical fiber bundle, the second optical fiber bundle and the reflection device are installed on the ultrasonic probe through the clamping part.
在本发明一实施例中，所述超声探头外表面和包覆装置内表面之间设有间隙，所述光纤束和所述反射装置位于所述间隙中，所述间隙内填充有耦合件。In an embodiment of the present invention, a gap is provided between the outer surface of the ultrasonic probe and the inner surface of the covering device, the optical fiber bundle and the reflection device are located in the gap, and the gap is filled with a coupling piece.
在本发明一实施例中，所述反射装置的倾斜角度为60°-80°。In an embodiment of the present invention, the inclination angle of the reflection device is 60°-80°.
在本发明一实施例中，所述反射装置包括第一平面镜和第二平面镜，所述第一平面镜位于第一光纤束末端的延长线上，所述第二平面镜位于第二光纤束末端的延长线上。In one embodiment of the present invention, the reflection device includes a first plane mirror and a second plane mirror, the first plane mirror is located on the extension line of the end of the first fiber bundle, and the second plane mirror is located on the extension line of the end of the second fiber bundle on-line.
本发明第二方面一实施例提供了一种光声成像系统，包括激光发生装置、光路系统、光声探头和成像装置，其中，An embodiment of the second aspect of the present invention provides a photoacoustic imaging system, including a laser generator, an optical system, a photoacoustic probe, and an imaging device, wherein,
所述激光发生装置用于发出激光；The laser generating device is used to emit laser light;
所述光路系统用于传输所述激光发生装置发出的激光给光声探头；The optical path system is used to transmit the laser light emitted by the laser generating device to the photoacoustic probe;
所述光声探头为上述的光声探头，所述光声探头中的光纤束接收光路系统传输的激光，所述超声探头用于接收样本发出的超声波；The photoacoustic probe is the above-mentioned photoacoustic probe, the optical fiber bundle in the photoacoustic probe receives the laser light transmitted by the optical path system, and the ultrasonic probe is used to receive the ultrasonic waves emitted by the sample;
成像装置，其用于接收超声探头传输的信号。The imaging device is used for receiving the signal transmitted by the ultrasound probe.
实施本发明实施例，具有如下有益效果：Implementing the embodiment of the present invention has the following beneficial effects:
由于本实施例具有反射装置，且反射装置位于第一光纤束末端和第二光纤束末端的延长线上，也即反射装置与第一光纤束末端和第二光纤束末端存在一定的距离，从而，从第一光纤束末端和第二光纤束出射的激光分别经空间展开后由反射装置反射到超声探头下方，斜入射到样本表面，并在样本内不同深度激发出光声信号，所产生的光声信号被超声探头接收，使激光在样本表面的照射区域与超声探头探测区域重叠面积大于探测区域面积的30％，比现有技术的重叠面积多，从而使成像效果较理想；而且，本实施例实现了不显著增加超声探头的尺寸，将激光简单高效地传递到样品的需要照射的部位。Since this embodiment has a reflection device, and the reflection device is located on the extension line of the first fiber bundle end and the second fiber bundle end, that is, there is a certain distance between the reflection device and the first fiber bundle end and the second fiber bundle end, thus , the laser light emitted from the end of the first fiber bundle and the second fiber bundle is respectively expanded in space, reflected by the reflection device to the bottom of the ultrasonic probe, obliquely incident on the sample surface, and excites photoacoustic signals at different depths in the sample, the generated light The acoustic signal is received by the ultrasonic probe, so that the overlapping area of the irradiation area of the laser on the sample surface and the detection area of the ultrasonic probe is greater than 30% of the area of the detection area, which is more than the overlapping area of the prior art, so that the imaging effect is ideal; moreover, this implementation The example realizes that the size of the ultrasonic probe is not significantly increased, and the laser light is simply and efficiently delivered to the part of the sample that needs to be irradiated.
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work.
图1是本发明现有技术光声探头的示意图；Fig. 1 is the schematic diagram of the prior art photoacoustic probe of the present invention;
图2是本发明一实施例光声探头的示意图；2 is a schematic diagram of a photoacoustic probe according to an embodiment of the present invention;
图示标号：Icon label:
10-超声探头；21-第一光纤束；22-第二光纤束；30-夹持件；41-第一平面镜；42-第二平面镜；50-包覆装置；60-间隙。10-ultrasonic probe; 21-first optical fiber bundle; 22-second optical fiber bundle; 30-clamping member; 41-first plane mirror; 42-second plane mirror; 50-coating device; 60-gap.
具体实施方式detailed description
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.
本发明实施例提供了一种光声探头，请参见图2，所述光声探头包括超声探头10、光纤束、反射装置和包覆装置50。An embodiment of the present invention provides a photoacoustic probe. Please refer to FIG. 2 . The photoacoustic probe includes an ultrasonic probe 10 , an optical fiber bundle, a reflection device and a coating device 50 .
所述超声探头10用于侦测样本发射出来的超声波，并将超声波信号转换为电信号进行传输，具体说来，当激光照射到样本区域时，例如照射到活体组织表面时，被照射的样本区域瞬时温度上升，随后该区域的样本产生热弹性膨胀的光声信号，该光声信号为超声波，超声波发射出来可以通过超声探头10采集。在本实施例中，所述超声探头10为经直肠阵列式内窥超声探头10，在本发明的其他实施例中，所述超声探头还可以是其他的种类。The ultrasonic probe 10 is used to detect the ultrasonic wave emitted by the sample, and convert the ultrasonic signal into an electrical signal for transmission. Specifically, when the laser irradiates the sample area, for example, when the laser irradiates the surface of living tissue, the irradiated sample The temperature of the area rises instantaneously, and then the sample in this area generates a photoacoustic signal of thermoelastic expansion. The photoacoustic signal is an ultrasonic wave, and the emitted ultrasonic wave can be collected by the ultrasonic probe 10 . In this embodiment, the ultrasonic probe 10 is a transrectal array endoscopic ultrasonic probe 10 , and in other embodiments of the present invention, the ultrasonic probe can also be of other types.
所述光纤束包括第一光纤束21和第二光纤束22，所述第一光纤束21和第二光纤束22都包括多跟光纤，所述第一光纤束21中光纤的数目范围为60根-80根，例如为60根、65根、70根、75根、80根等数目，所述第二光纤束22中光纤的数目范围为60根-80根，例如为60根、65根、70根、75根、80根等数目。该两个光纤束分别位于超声探头10的相对两侧，例如第一光纤束21位于超声探头10的左侧，第二光纤束22位于超声探头10的右侧，或者相反，或者第一光纤束21位于超声探头10的前侧，第二光纤束22位于超声探头10的后侧，或者相反。所述第一光纤束21和第二光纤束22用于传输激光。Described optical fiber bundle comprises first optical fiber bundle 21 and second optical fiber bundle 22, and described first optical fiber bundle 21 and second optical fiber bundle 22 all comprise multi-fiber, and the number scope of the optical fiber in described first optical fiber bundle 21 is 60 root-80, such as 60, 65, 70, 75, 80, etc., the number of optical fibers in the second optical fiber bundle 22 ranges from 60 to 80, such as 60, 65 , 70, 75, 80 and other numbers. The two optical fiber bundles are respectively located on opposite sides of the ultrasonic probe 10, for example, the first optical fiber bundle 21 is located on the left side of the ultrasonic probe 10, and the second optical fiber bundle 22 is located on the right side of the ultrasonic probe 10, or vice versa, or the first optical fiber bundle 21 is located at the front side of the ultrasound probe 10, and the second optical fiber bundle 22 is located at the rear side of the ultrasound probe 10, or vice versa. The first fiber bundle 21 and the second fiber bundle 22 are used to transmit laser light.
所述反射装置位于第一光纤束21末端和第二光纤束22末端的延长线上，也即所述反射装置位于第一光纤束21传出的激光的路径上，所述反射装置也位于第二光纤束22传出的激光的路径上，所述反射装置倾斜设置，且所述反射装置的中心轴靠近光纤束的一端距离超声探头10中心轴的距离大于反射装置的中心轴远离光纤束的一端距离超声探头10中心轴的距离，也即反射装置的中心轴从上到下向内倾斜，在这里，反射装置的中心轴为其纵轴，也即反射装置从上到下依次向超声探头10方向倾斜，所述反射装置用于改变第一光纤束21和第二光纤束22出射的激光的方向，以将第一光纤束21和第二光纤束22出射的激光反射向样本上，且所述反射装置用于使第一激光束和第二激光束出射的激光在样本表面的照射区域与超声探头10的探测区域的重叠面积大于探测区域面积的30％，例如为30％、40％、50％、60％、70％、80％、90％、95％、100％等，当为100％时，所述照射区域与所述探测区域完全重叠。The reflection device is located on the extension line of the end of the first fiber bundle 21 and the end of the second fiber bundle 22, that is, the reflection device is located on the path of the laser emitted by the first fiber bundle 21, and the reflection device is also located at the first fiber bundle 21. On the path of the laser light emitted by the two optical fiber bundles 22, the reflection device is arranged obliquely, and the distance between the central axis of the reflection device and the end of the fiber bundle near the central axis of the ultrasonic probe 10 is greater than that of the central axis of the reflection device away from the fiber bundle. The distance between one end and the central axis of the ultrasonic probe 10, that is, the central axis of the reflecting device is inclined inwardly from top to bottom. Here, the central axis of the reflecting device is its longitudinal axis, that is, the reflecting device moves toward the ultrasonic probe from top to bottom 10 direction is inclined, and the reflection device is used to change the direction of the laser light emitted by the first fiber bundle 21 and the second fiber bundle 22, so as to reflect the laser light emitted by the first fiber bundle 21 and the second fiber bundle 22 to the sample, and The reflecting device is used to make the overlapping area of the laser irradiation area on the sample surface emitted by the first laser beam and the second laser beam and the detection area of the ultrasonic probe 10 be greater than 30% of the area of the detection area, for example, 30%, 40%. , 50%, 60%, 70%, 80%, 90%, 95%, 100%, etc., when it is 100%, the irradiation area and the detection area completely overlap.
由于本实施例具有反射装置，且反射装置位于第一光纤束21末端和第二光纤束22末端的延长线上，也即反射装置与第一光纤束21末端和第二光纤束22末端存在一定的距离，从而，从第一光纤束21末端和第二光纤束22出射的激光分别经空间展开后由反射装置反射到超声探头10下方，斜入射到样本表面，并在样本内不同深度激发出光声信号，所产生的光声信号被超声探头10接收，使激光在样本表面的照射区域与超声探头10探测区域重叠面积大于探测区域面积的30％，比现有技术的重叠面积多，从而使成像效果较理想；而且，本实施例实现了不显著增加超声探头10的尺寸，将激光简单高效地传递到样品的需要照射的部位。Since the present embodiment has a reflection device, and the reflection device is located on the extension line of the first fiber bundle 21 end and the second fiber bundle 22 end, that is, there is a certain distance between the reflection device and the first fiber bundle 21 end and the second fiber bundle 22 end. Therefore, the laser light emitted from the end of the first optical fiber bundle 21 and the second optical fiber bundle 22 respectively expands in space and is reflected by the reflection device to the bottom of the ultrasonic probe 10, obliquely incident on the sample surface, and excites light at different depths in the sample Acoustic signal, the generated photoacoustic signal is received by the ultrasonic probe 10, so that the overlapping area of the irradiation area of the laser on the sample surface and the detection area of the ultrasonic probe 10 is greater than 30% of the detection area, which is more than the overlapping area of the prior art, so that The imaging effect is ideal; moreover, this embodiment realizes that the size of the ultrasonic probe 10 is not significantly increased, and the laser light is simply and efficiently delivered to the part of the sample that needs to be irradiated.
在本实施例中，所述第一光纤束21和第二光纤束22的首端是圆形或者方形，所述第一光纤束21中光纤的数目范围为60根-80根，例如为60根、65根、70根、72根、74根、75根、76根、78根、80根等数目，所述第二光纤束22中光纤的数目范围也为60根-80根，例如为60根、65根、70根、72根、74根、75根、76根、78根、80根等数目。由于超声探头10的末端体积比较大，也即超声探头10靠近样本一端体积比较大，为了减小光声探头的尺寸，所述第一光纤束21和第二光纤束22靠近反射装置的一端的厚度小于远离反射装置一端的厚度，从而可以减小整个光声探头末端的厚度，可以减小尺寸。在本实施例中，所述第一光纤束21和第二光纤束22靠近反射装置的一端为扁平状，从而既可以减小整个光声探头的末端的厚度，而且也可以增加第一光纤束21和第二光纤束22照射到样本表面的照射区域面积，从而，后面再通过调节反射装置的倾斜角度，使第一激光束和第二激光束出射的激光在样本表面的照射区域与超声探头10的探测区域的重叠面积大于探测区域面积50％，例如50％、60％、70％、80％、900％、100％等，最佳可以达到100％，也即所述照射区域与所述探测区域完全重叠。In this embodiment, the first ends of the first optical fiber bundle 21 and the second optical fiber bundle 22 are circular or square, and the number of optical fibers in the first optical fiber bundle 21 ranges from 60 to 80, for example, 60 root, 65, 70, 72, 74, 75, 76, 78, 80, etc., the number of optical fibers in the second optical fiber bundle 22 also ranges from 60 to 80, for example 60, 65, 70, 72, 74, 75, 76, 78, 80, etc. Since the volume of the end of the ultrasonic probe 10 is relatively large, that is, the volume of the end of the ultrasonic probe 10 close to the sample is relatively large, in order to reduce the size of the photoacoustic probe, the first optical fiber bundle 21 and the second optical fiber bundle 22 near the end of the reflection device The thickness is smaller than the thickness of the end away from the reflection device, so that the thickness of the end of the entire photoacoustic probe can be reduced, and the size can be reduced. In this embodiment, the ends of the first fiber bundle 21 and the second fiber bundle 22 near the reflection device are flat, so that the thickness of the end of the entire photoacoustic probe can be reduced, and the first fiber bundle can also be increased. 21 and the second optical fiber bundle 22 irradiate the area of the irradiation area on the sample surface, thereby, by adjusting the inclination angle of the reflection device later, the laser beams emitted by the first laser beam and the second laser beam are in the same area as the irradiation area of the sample surface and the ultrasonic probe The overlapping area of the detection area of 10 is greater than 50% of the area of the detection area, such as 50%, 60%, 70%, 80%, 900%, 100%, etc., and the best can reach 100%, that is, the irradiation area and the The detection areas overlap completely.
在本实施例中，所述第一光纤束21和第二光纤束22紧贴所述超声探头10的外表面设置，所述第一光纤束21与超声探头10末端的距离范围为5-15mm，例如为5mm、7mm、9mm、10mm、12mm、15mm等；所述第二光纤束22与超声探头10末端的距离范围也为5-15mm，例如为5mm、7mm、9mm、10mm、12mm、15mm等，从而方便反射装置的设置和调节照射区域面积大小。In this embodiment, the first optical fiber bundle 21 and the second optical fiber bundle 22 are arranged close to the outer surface of the ultrasonic probe 10, and the distance between the first optical fiber bundle 21 and the end of the ultrasonic probe 10 is in the range of 5-15mm , such as 5mm, 7mm, 9mm, 10mm, 12mm, 15mm, etc.; the distance between the second optical fiber bundle 22 and the end of the ultrasonic probe 10 is also 5-15mm, such as 5mm, 7mm, 9mm, 10mm, 12mm, 15mm etc., so as to facilitate the setting of the reflecting device and the adjustment of the size of the irradiation area.
在本实施例中，所述超声探头10呈U型，也即超声探头10沿垂直图2纸面方向剖下去为U型，在图2所示的超声探头方向上，由于超声探头10位U型，从而超声探头10的左面和右面都为扁平区域，所述第一光纤束21和所述第二光纤束22分别位于U型超声探头的扁平区域，例如，所述第一光纤束21位于U型超声探头10左侧的扁平区域，所述第二光纤束22位于U型超声探头10右侧的扁平区域，从而方便了第一光纤束21和第二光纤束22的稳定夹持在超声探头10上。In the present embodiment, the ultrasonic probe 10 is U-shaped, that is, the ultrasonic probe 10 is U-shaped when cut along the direction perpendicular to the paper surface of FIG. 2 . In the direction of the ultrasonic probe shown in FIG. type, so that the left side and the right side of the ultrasonic probe 10 are flat areas, and the first optical fiber bundle 21 and the second optical fiber bundle 22 are respectively located in the flat area of the U-shaped ultrasonic probe, for example, the first optical fiber bundle 21 is located in the flat area of the U-shaped ultrasonic probe. The flat area on the left side of the U-shaped ultrasonic probe 10, the second optical fiber bundle 22 is located in the flat area on the right side of the U-shaped ultrasonic probe 10, thereby facilitating the stable clamping of the first optical fiber bundle 21 and the second optical fiber bundle 22 in the ultrasonic Probe 10 on.
在本实施例中，所述反射装置包括第一反射装置和第二反射装置，所述第一反射装置和第二反射装置分开设置，所述第一反射装置位于第一光纤束21末端的延长线上，所述第二反射装置位于第二光纤束22末端的延长线上，所述反射装置为平面镜，也即第一反射装置为第一平面镜41，所述第二反射装置为第二平面镜42。所述反射装置的倾斜角度为60°-80°，例如为60°、65°、70°、75°、80°等角度也即在本实施例中，所述第一平面镜41的倾斜角度为60°-80°，例如为60°、65°、70°、75°、80°等角度，所述第二平面镜42的倾斜角度为60°80°，例如为60°、65°、70°、75°、80°等角度。在此范围内，所述反射装置反射的激光在样本表面的照射区域与超声探头10的探测区域的重叠面积较大，例如达到探测区域面积的70％，甚至100％，此时所述照射区域与所述探测区域完全重叠。In this embodiment, the reflective device includes a first reflective device and a second reflective device, the first reflective device and the second reflective device are set separately, and the first reflective device is located at the extension of the end of the first optical fiber bundle 21 On the line, the second reflection device is located on the extension line of the second optical fiber bundle 22 end, the reflection device is a plane mirror, that is, the first reflection device is a first plane mirror 41, and the second reflection device is a second plane mirror 42. The inclination angle of the reflecting device is 60°-80°, such as 60°, 65°, 70°, 75°, 80°, etc. That is, in this embodiment, the inclination angle of the first flat mirror 41 is 60°-80°, such as 60°, 65°, 70°, 75°, 80°, etc., the inclination angle of the second plane mirror 42 is 60°80°, such as 60°, 65°, 70° , 75°, 80° and other angles. Within this range, the overlapping area of the irradiation area of the laser beam reflected by the reflection device on the sample surface and the detection area of the ultrasonic probe 10 is relatively large, for example reaching 70% or even 100% of the area of the detection area. completely overlap the detection area.
在本实施例中，所述光声探头还包括夹持件30，所述第一光纤束21、第二光纤束22和反射装置通过夹持件30安装在超声探头10上。所述夹持件30例如为夹子。从而，第一光纤束21、第二光纤束22和反射装置可以稳靠的安装在超声探头10上。In this embodiment, the photoacoustic probe further includes a clamping part 30 , and the first optical fiber bundle 21 , the second optical fiber bundle 22 and the reflection device are installed on the ultrasonic probe 10 through the clamping part 30 . The clip 30 is, for example, a clip. Therefore, the first optical fiber bundle 21 , the second optical fiber bundle 22 and the reflection device can be stably installed on the ultrasound probe 10 .
在本实施例中，所述光声探头还包括包覆装置50，所述包覆装置50构成所述光声探头的外壳，所述包覆装置50用于包覆所述超声探头10、光纤束和反射装置，从而使所述超声探头10、光纤束和反射装置形成一体，可以防止光纤束、反射装置等损坏，而且可以保护超声探头10。在本实施例中，所述光纤束与所述包覆装置50的内表面具有一定距离。In this embodiment, the photoacoustic probe further includes a coating device 50, the coating device 50 constitutes the housing of the photoacoustic probe, and the coating device 50 is used to cover the ultrasonic probe 10, optical fiber Bundle and reflection device, so that the ultrasonic probe 10, optical fiber bundle and reflection device are integrated, which can prevent damage to the optical fiber bundle, reflection device, etc., and can protect the ultrasonic probe 10. In this embodiment, the optical fiber bundle has a certain distance from the inner surface of the cladding device 50 .
在本实施例中，所述超声探头10外表面和包覆装置50内表面之间设有间隙60，所述光纤束和所述反射装置位于所述间隙60中，所述间隙60内填充有耦合件，在本实施例中，所述耦合件例如为水。In this embodiment, a gap 60 is provided between the outer surface of the ultrasonic probe 10 and the inner surface of the covering device 50, the optical fiber bundle and the reflection device are located in the gap 60, and the gap 60 is filled with A coupling piece, in this embodiment, the coupling piece is, for example, water.
本发明一实施例还提供了一种光声成像系统，所述光声成像系统包括激光发生装置、光路系统、光声探头和成像装置，所述激光发生装置用于发出激光，所述激光为脉冲激光，所述光路系统用于传输所述激光发生装置发出的激光给光声探头，所述光路系统包括光学组件，所述光学组件例如为透镜、反射镜等，所述光声探头为上述的光声探头，所述光声探头中的光纤束接收光路系统传输的激光，也即光路系统传输的激光耦合进入到第一光纤束21和第二光纤束22的首端，所述超声探头10用于接收样本发出的超声波，也即用于接收样本发出的光声信号，所述超声探头10将光声信号转换为电信号；所述成像装置用于接收超声探头10传输的信号，以得到高质量的图像。An embodiment of the present invention also provides a photoacoustic imaging system. The photoacoustic imaging system includes a laser generator, an optical path system, a photoacoustic probe, and an imaging device. The laser generator is used to emit laser light, and the laser beam is Pulse laser, the optical path system is used to transmit the laser light emitted by the laser generating device to the photoacoustic probe, the optical path system includes optical components, such as lenses, mirrors, etc., the photoacoustic probe is the above-mentioned A photoacoustic probe, the optical fiber bundle in the photoacoustic probe receives the laser light transmitted by the optical path system, that is, the laser light transmitted by the optical path system is coupled into the head ends of the first optical fiber bundle 21 and the second optical fiber bundle 22, and the ultrasonic probe 10 is used to receive the ultrasonic wave sent by the sample, that is, to receive the photoacoustic signal sent by the sample, and the ultrasonic probe 10 converts the photoacoustic signal into an electrical signal; the imaging device is used to receive the signal transmitted by the ultrasonic probe 10 to Get high quality images.
需要说明的是，本说明书中的各个实施例均采用递进的方式描述，每个实施例重点说明的都是与其它实施例的不同之处，各个实施例之间相同相似的部分互相参见即可。对于装置实施例而言，由于其与方法实施例基本相似，所以描述的比较简单，相关之处参见方法实施例的部分说明即可。It should be noted that each embodiment in this specification is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. For the same and similar parts in each embodiment, refer to each other, that is, Can. As for the device embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and for related parts, please refer to the part of the description of the method embodiment.
通过上述实施例的描述，本发明具有以下优点：Through the description of the foregoing embodiments, the present invention has the following advantages:
由于本实施例具有反射装置，且反射装置位于第一光纤束末端和第二光纤束末端的延长线上，也即反射装置与第一光纤束末端和第二光纤束末端存在一定的距离，从而，从第一光纤束末端和第二光纤束出射的激光分别经空间展开后由反射装置反射到超声探头下方，斜入射到样本表面，并在样本内不同深度激发出光声信号，所产生的光声信号被超声探头接收，使激光在样本表面的照射区域与超声探头探测区域重叠面积大于探测区域面积的30％，比现有技术的重叠面积多，从而使成像效果较理想；而且，本实施例实现了不显著增加超声探头的尺寸，将激光简单高效地传递到样品的需要照射的部位。Since this embodiment has a reflection device, and the reflection device is located on the extension line of the first fiber bundle end and the second fiber bundle end, that is, there is a certain distance between the reflection device and the first fiber bundle end and the second fiber bundle end, thus , the laser light emitted from the end of the first fiber bundle and the second fiber bundle is respectively expanded in space, reflected by the reflection device to the bottom of the ultrasonic probe, obliquely incident on the sample surface, and excites photoacoustic signals at different depths in the sample, the generated light The acoustic signal is received by the ultrasonic probe, so that the overlapping area of the irradiation area of the laser on the sample surface and the detection area of the ultrasonic probe is greater than 30% of the area of the detection area, which is more than the overlapping area of the prior art, so that the imaging effect is ideal; moreover, this implementation The example realizes that the size of the ultrasonic probe is not significantly increased, and the laser light is simply and efficiently delivered to the part of the sample that needs to be irradiated.
可以理解的是，本发明的上述实施例在不冲突的情况下，可以相互结合来获得更多的实施例。It can be understood that the above-mentioned embodiments of the present invention can be combined with each other to obtain more embodiments under the condition of no conflict.
在本发明的描述中，需要理解的是，术语“中心”、“上”、“下”、“竖直”、“水平”、“顶”、“底”、“内”、“外”、“顺时针”、“逆时针”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括一个或者更多个该特征。在本发明的描述中，“多个”的含义是两个或两个以上，除非另有明确具体的限定。In describing the present invention, it is to be understood that the terms "center", "upper", "lower", "vertical", "horizontal", "top", "bottom", "inner", "outer", The orientation or positional relationship indicated by "clockwise", "counterclockwise", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying the referred device or element Must be in a particular orientation, be constructed in a particular orientation, and operate in a particular orientation, and therefore should not be construed as limiting the invention. In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, a feature defined as "first" and "second" may explicitly or implicitly include one or more of these features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.
在本发明中，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或一体地连接；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。In the present invention, unless otherwise clearly specified and limited, terms such as "installation", "connection", "connection" and "fixation" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection , or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.
以上所揭露的仅为本发明较佳实施例而已，当然不能以此来限定本发明之权利范围，因此依本发明权利要求所作的等同变化，仍属本发明所涵盖的范围。The above disclosures are only preferred embodiments of the present invention, and certainly cannot limit the scope of rights of the present invention. Therefore, equivalent changes made according to the claims of the present invention still fall within the scope of the present invention.
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| CN201710046338.4ACN106691390B (en) | 2017-01-22 | 2017-01-22 | A photoacoustic probe and photoacoustic imaging system |
| Application Number | Priority Date | Filing Date | Title |
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| CN201710046338.4ACN106691390B (en) | 2017-01-22 | 2017-01-22 | A photoacoustic probe and photoacoustic imaging system |
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| CN106691390Atrue CN106691390A (en) | 2017-05-24 |
| CN106691390B CN106691390B (en) | 2020-04-14 |
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| CN201710046338.4AActiveCN106691390B (en) | 2017-01-22 | 2017-01-22 | A photoacoustic probe and photoacoustic imaging system |
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