A kind of medicament sprayerTechnical field
The present invention relates to a kind of medicament sprayer, more particularly, to one kind can convenient, stably by multi-medicament component mistThe device changed, mix.
Background technology
In modern surgery operation, some medicines need to join to be used, such as Clinical practice fibrin sealant(fibrin sealant), the key component of this product is the protein-based one-tenth such as Fibrinogen, the xiii factor, thrombin, fnDivide and ca2+Deng salt ion composition, this pure biological product, simulate the final stage of body hemostasis and work, permissibleFor stopping blooding, bonding, wound closure, wound healing etc..
Fibrinogen in fibrin sealant is the structural protein in Blood Coagulation Process mid-term Main Function, leads toCrossing thrombin makes Fibrinogen hydrolysis fibroblast cells monomer, and this fiber monomer is condensed into little fiber, then again byGradually form the reticular fiber of three-dimensional.The xiii factor is in ca2+In the presence of.Activity form is changed into by thrombin hydrolytic scission.SoThe active xiii factor being activated afterwards is converted into the non-covalent bond between the fiber monomer assembled covalently by transaminationKey.This reduces the sensitivity of the proteolytic digestion to fibrin solvent for the fiber gel, increase the total of gel simultaneouslyBody intensity and dynamics so as to be adhere strongly on wet wound surface, formed a kind of semihard, hemostasis, immobilising viscousProperty material, play hemostasis and bonding wound effect.
Because the condition that Fibrinogen and thrombin react is room temperature, normal pressure, therefore, both can not mix in advanceClose, need to mix Fibrinogen and thrombin when using temporarily, and coat rapidly to wound surface.
In prior art, generally use double syringe blender as the applicator of bio-tissue binding agent, by fibreTwo kinds of drug components such as fibrillarin original solution and thrombin solution are added separately in different syringes, and drug component is releasedMix in same hydrid component afterwards, then spray atomization, medicinal liquid mixing as disclosed in cn2561423y, cn101554502aAerosol apparatus.There are some problems in the blender of this structure, as poor in atomizing effect, and the droplet size after atomization is larger；Next, byIt is much smaller than syringe intracavity diameter in dispersive nozzle diameter, releases extremely difficult during medicine, need to apply very big external force；SeparatelyOutward, after being applied to the pressure release of syringe, in syringe, syringe plunger can be rebounded certain distance by medicine resilience, releasesInjection volume is difficult to control to.
Content of the invention
The release medicine existing for current multicomponent pharmaceutical blender is difficult, atomizing effect is poor and metering is inaccurateProblem, the invention provides a kind of medicament sprayer and a kind of medicine spray method.
The present invention the is to provide a kind of medicament sprayer on one side, preferably multicomponent pharmaceutical mixing sprayer, includingAt least one drug component syringe, at least one air syringe.
Wherein, at least one drug component syringe described, at least one air syringe all include cavity, from cavity endPush rod, the outlet of cavity top end of described cavity is stretched at end.
Wherein, the outlet of at least one drug component syringe described, at least one air syringe is to sameMixing chamber, mixing chamber connects spray nozzle.
In one preferred embodiment of the invention, described drug component syringe at least two.
In one preferred embodiment of the invention, described mixing chamber inwall is provided with least one fluid intake, describedThe cavity of drug component syringe is communicated to mixing chamber by the fluid intake of mixing chamber's inwall.Wherein, described medicine groupDispensing emitter can be to connect mixing chamber by identical or different fluid intakes.
In an advantageous embodiment, described medicament sprayer, preferably multicomponent pharmaceutical mixing sprayer include twoDrug component syringe, an air syringe.Wherein, described air syringe can be in two drug component syringesBetween.
In one preferred embodiment of the invention, described medicament sprayer, preferably multicomponent pharmaceutical mixing sprayerIncluding nebulizer, described nebulizer includes: described mixing chamber, described spray nozzle and connection member.Wherein, described medicineThing component syringe is connected with nebulizer by described connection member with air syringe.
In one preferred embodiment of the invention, described nebulizer includes multiple first medicine circulation ducts, and describedOne medicine circulation duct extends along described nebulizer base wall to the direction of described mixing chamber, and with described mixing chamber evenLogical；Preferably, connected with mixing chamber by described fluid intake.
In one preferred embodiment of the invention, described spray nozzle is hollow structure, including connection end and spraying end,Described mixing chamber both ends open, described spray nozzle connection end is connected at the one end open of described mixing chamber, described sprayThe hollow structure of atomizing nozzle is connected with described mixing chamber.
It is highly preferred that forming the second mixing chamber between the spraying end of described spray nozzle and mixing chamber.
In an advantageous embodiment, described mixing chamber is provided with to the second hybrid chamber towards the end of the second mixing chamberThe protuberance that room extends, protuberance inserts in the segment space of the second mixing chamber.
In a kind of more preferred embodiment, described mixing chamber is being provided with to the end non-central location of the second mixing chamberFluid issuing, and the fluid issuing of preferably eccentric position is communicated to the second mixing chamber.
In a kind of more preferred embodiment of the present invention, on spray nozzle inwall, in addition to the coupling part with mixing chamber,It is provided with groove, and be preferably the groove but it is also possible to be other forms for the spiral grooves extending to spraying end.Wherein, described mixedThe fluid issuing closing chamber is communicated to the second mixing chamber by described groove.
In one preferred embodiment of the invention, it is provided with intake chute inside described spraying end, intake chute connects spraying sprayMouth edge, it is highly preferred that the intake chute other end connects the spiral grooves of inwall, in more preferred embodiment, described intake chute is anotherOne end is tangent with edge in spraying.
In one preferred embodiment of the invention, the dispensing end of described air syringe extend into described mixing chamber,It is highly preferred that sealing between described air syringe dispensing end outer wall and mixing chamber.
In an advantageous embodiment, described nebulizer also includes housing, and described housing is the hollow cavity of both ends open,Described medicament mixed room and spray nozzle are located at described enclosure interior, and the side wall of described medicament mixed room and described connection member is insertedIt is connected in described inner walls, described mixing chamber inserts the one end open of described housing, at least part of position of described connection memberIn described enclosure interior.
In an advantageous embodiment, the push rod of described drug component syringe and air syringe connects in syringe exteriorIt is connected into one, or promoted by same pushing mechanism.
In an advantageous embodiment, described medicament sprayer, preferably multicomponent pharmaceutical mixing sprayer also include notingEmitter housing, drug component syringe and air syringe are fixed by described injector housing.
In more preferred embodiment, the housing of described force nebulizer and/or connection member are connected with described injector housing.
In one preferred embodiment of the invention, described medicament sprayer, preferably multicomponent pharmaceutical mixing sprayerAlso include medicine glass perforator, for adding medicine into drug component syringe.
In a kind of more preferred embodiment, described medicine glass perforator, comprising: multiple medicine glasses and medicine glass support.
Preferably, described medicine glass opening is towards same direction.
Preferably, it is equipped with puncture needle in described medicine glass, described puncture needle bottom is provided with imbibition passage.
Preferably, described medicine glass support is provided with medicine circulation duct, and described medicine circulation duct is with described imbibition passage evenLogical.
Described medicine glass support is provided with connector, is used for being connected to syringe, and the end of described connector is provided with connector,For connecting syringe internal cavities；Described connector connects described medicinal fluid pipeline.
In an advantageous embodiment, described medicine glass perforator can include medicine glass support, and described medicine glass is connected to described medicineOn cup, and medicine glass support is connected by described medicine glass support.
In an advantageous embodiment, described medicine glass support is additionally provided with air flow conduit, and described air flow conduit is evenLogical air.
In an advantageous embodiment, described medicine glass support is additionally provided with air intake, described air flow conduit passes through instituteState air intake connection air.
As a preferred embodiment of the present invention, described air intake was additionally provided with the junction of described circulation ductFilter screen, the diameter with diameter greater than described air flow conduit of described drainage screen, described drainage screen is used for filtering the described sky of entranceAir-flow thread a pipe in air.
Wherein, in a kind of more preferred embodiment, contain disinfection filter screen in described drainage screen, or contain disinfectionMaterial.
Second aspect of the present invention is to provide a kind of spray method, preferably drug component mixed atomizing method, comprising:
Promote (preferably at least two) the drug component syringe containing medicine, the air syringe of filling air simultaneouslyPush rod, medicine is expelled to together with air medicament mixed within the chamber, medicament mixed chamber diameter be more than drug component streamBody passage, therefore, medicine forms turbulent flow, is mixed；
Described push rod is pushed away, mixed medicine, under pressure promotion, passes through spray nozzle from medicament mixed chamber before continuationAtomization sprays.
In an advantageous embodiment, the injection of at least two groups of described drug component syringe, and, each group drug componentDrug component in device is different.
In an advantageous embodiment, mixed medicine, under pressure promotion, is gone out by fluid from medicament mixed chamberMouth enters the second mixing chamber, and the second mixing chamber, with diameter greater than fluid issuing, forms turbulent flow again, mixed further,Then, under pressure promotion, it is atomized by spray nozzle from medicament mixed chamber and sprays.
In an advantageous embodiment, under pressure promotion, spirally flow path flows to described mixed medicineSpray nozzle or flow to the second mixing chamber.
In the above of the present invention, described first aspect and second aspect can be mutually combined, various preferred embodiments, morePreferred embodiment can also be mutually combined.
Aerosol apparatus that the present invention provides, it is preferably drug component mixing sprayer, during use, air syringe and medicineComponent syringe before pushes away simultaneously, and because air has larger compressibility, the resilience of drug component pressure is applied to skyGas syringe, mixing chamber, are compressed to air, thus reducing the power promoting required for drug component syringe；Meanwhile,The presence of air is so that drug component in mixing chamber being capable of more preferable mix homogeneously；Additionally, medicinal mixture is from spraying sprayAfter mouth sprays, because volume of air expands rapidly, liquid can be dispersed as less drop, thus obtaining preferably atomization effectReally.
Brief description
Fig. 1 is the multicomponent pharmaceutical mixing sprayer overall structure diagram of three syringes；
Fig. 2 is the multicomponent pharmaceutical mixing sprayer syringe part-structure schematic diagram of three syringes；
Fig. 3 is the multicomponent pharmaceutical mixing sprayer syringe partial cross structural representation of three syringes；
Fig. 4 is the injector housing part-structure schematic diagram of the multicomponent pharmaceutical mixing sprayer of three syringes；
Fig. 5 is the nebulizer partial sectional view of the multicomponent pharmaceutical mixing sprayer of three syringes；
Fig. 6 is the nebulizer cross section structure diagram of the multicomponent pharmaceutical mixing sprayer of three syringes；
Fig. 7 is the nebulizer fractionation structural representation of the multicomponent pharmaceutical mixing sprayer of three syringes；
Fig. 8 is present invention spraying spray nozzle cross section structure diagram；
Fig. 9 is the medicine glass perforator surface structure schematic diagram of the multicomponent pharmaceutical mixing sprayer of three syringes；
Figure 10 is the medicine glass perforator fractionation structural representation of the multicomponent pharmaceutical mixing sprayer of three syringes；
Figure 11 is the medicine glass perforator cross section structure diagram of the multicomponent pharmaceutical mixing sprayer of three syringes.
Specific embodiment
Embodiment 1
See figures.1.and.2, multicomponent pharmaceutical mixing sprayer of the present invention includes syringe part and aerosol apparatus part.
, syringe part includes two drug component syringes 11 and an air syringe taking three syringes as a example12, air syringe 12 is located between two drug component syringes 11, but the present embodiment is not limited to three syringes,As long as at least two drug component syringes 11 and at least one air syringe 12.
Referring to figs. 1 to Fig. 3, air syringe 12 and two drug component syringes 11 are fixed by fixing shell 10.Drug component injector push-rod 110, the outer end of air syringe push rod 120 are linked together by integral piece 13, so permissiblePush or pull on the push rod of three syringes simultaneously；The head end of syringe is provided with fixture 14, and syringe is fixed by fixture 14In fixing shell 10.
With reference to Fig. 3, fixture 14 can be the cylindrical structure of two ends insertion, and inner surface is provided with screw thread, and passes through thread bushPut the head in centrally located syringe, such as outside air syringe liquid outlet 122.In addition, fixture can also beBore a hole including three, the head of three syringes passes in perforation.
In the present invention, fixing shell 10 can be two parts up and down fastening, and such as Fig. 4 gives a kind of fixing shell 10Upper part-structure, lower partly can be symmetrical with it, it is fixing that two parts pass through multiple connectors 103.Fixing shell 10 includesThe outside framework 100 of the left and right sides, three syringes are located between outside framework 100.Between outside framework 100, it is provided with head limiting section101 and afterbody limiting section 102.
Head limiting section 101, afterbody limiting section 102 include three curved portions, and three syringes are located at different curved portionsThe inner recess space being formed.Head limiting section 101 is provided with baffle plate (not showing in accompanying drawing), baffle plate towards the side of blowing portionIt is provided with perforation, the head for syringe stretches out, but syringe tube is by baffle.Pass through plug-in unit between fixed mount 14 and baffle plateStructure connects.
Blowing portion includes aerosol apparatus 2, and with reference to Fig. 5 to Fig. 7, aerosol apparatus 2 include shell 20, drug component passage 21, skyGas passage 22, mixing chamber 23, spray nozzle 24.
The head 112 of drug component syringe is connected with drug component passage 21, and air syringe head 122 is led to airRoad 22 connects, and drug component passage 21 and air duct 22 are all communicated to mixing chamber 23.Push rod is pressed, the push rod of syringeBefore push away, the drug component of different syringes passes through different drug channels 21 and enters mixing chamber 23, and meanwhile, air is injected simultaneouslyAir in device 12 enters mixing chamber 23 by air duct 22, and drug component and air are mixed in mixing chamber 23Close.Mixing chamber 23 front end is provided with flow export 231, and the mixture in mixing chamber 23 enters spray nozzle by flow export 23124 intracavity, is sprayed by top aperture 241.
The diameter of mixing chamber 23 is more larger than drug channel 21, and drug component enters and forms turbulent flow during mixing chamber 23, fromAnd there is good mixed effect, meanwhile, air participates in turbulent flow and mixing in mixing chamber, further increases mixing effectReally.
In addition, in the case of pressing to push rod, the pressure pushing away before push rod usually makes medicine produce bounce, in addition, sprayAtomizing nozzle aperture 241 diameter very little, limited by drug flux, usually therefore leads in prior art be difficult to promote push rod and push rodBounce-back.But drug component syringe of the present invention and air syringe simultaneously in the presence of, the thrust of push rod and drug componentBounce, is transferred to mixing chamber 23 by medicinal fluid passage 22, and passes to air in mixing chamber 23 furtherAir in air syringe 12 is passed to by air duct 22, air has good compressibility, therefore, when promoting push rodSubstantially save external force it is easier to promote.
Additionally, in prior art, due to the elastic force of medicine, when stopping pressing to push rod, drug component also may proceed to fromSpray in spray nozzle aperture 241, exist delayed, but it was unexpectedly determined that drug component syringe of the present invention and air noteWhen emitter simultaneously promotion, once stopping promoting, then stop spraying at once, and push rod does not rebound.
And, air is compressed in mixture, after spraying through small holes 241, because pressure suddenly disappears, compressed airVery fast collision, occurs " blast ", liquid is atomized further, improves atomizing effect.
Embodiment 2
With reference to Fig. 5 to Fig. 7, in the present embodiment, aerosol apparatus 2 include shell 20, spray nozzle 24, mixing chamber 23, support26th, collet 25.
Support 26 includes ledge, mixing chamber 23 in the ledge of support 26, the ledge of support 26Bottom is provided with the extension stretching to both sides.
Collet 25 is fastened with extension, in the present embodiment, is provided with horizontal drug channel 212 inside extension；Or bottomSupport 25 is provided with horizontal drug channel 212；Or, after fastening between extension and collet 25 contact surface, form horizontal drug channel212.Laterally one end of drug channel 212 is connected with the drug channel 22 in protuberance.
Collet 25 is provided with the first connection end 211 connecting drug component syringe 11 head end and connects air syringe 12Second connection end 221；Each drug component syringe 11 connects the first different connection ends 211, as shown in Figures 5 to 7；ButIn the case that drug component allows, each drug component syringe 11 can also be coupled to same first connection end 211.EmptyGas passage 22 one end is communicated to mixing chamber 23 below support 26, and the other end connects air injection by the second connection end 211Device 12.
Outside the air duct of collet 25, it is surrounded with lobe 27, lobe is inserted into support 26, be easy to support 26 and bottomThe connection of support 25.The two ends of collet 25 can also pass through the connection member such as fastening, plug-in unit, fastener and the extension of support 26 between28 are connected.
Spray nozzle 24 is located at support 26 protuberance end, and mixture is sent into by the flow export 231 at mixing chamber 23 topSpray nozzle, sprays atomization by spray nozzle aperture 241.Preferably, flow export 231 and drug channel 21, air duct 22It is not in same straight line.Or flow export 231 is not in the center of mixing chamber 23 head, but eccentric setting.
In the present embodiment, with reference to Fig. 6 to Fig. 8, the protuberance of spray nozzle 24 one end open and opening and support 26Connect, for example, protuberance (or mixing chamber 23) top of support 26 is provided with slot, and spray nozzle 24 is inserted in slot.MixedClose the top of chamber 23, be provided with the extension 232 stretching to spray nozzle 24 inner space, nozzle wall 243 inner surface is formed with spiral shellSpin slot, extension 232 sidewall surfaces enter helicla flute near spiral fluted threaded top, the mixed liquor that flow export 231 flows out, andAnd form screw along helicla flute.
Leave in spray nozzle 24 certain space formed the second mixing chamber 240, mixed liquor along helicla flute flow into this secondMixing chamber 240, carries out second mixing.Second mixing chamber 240 is connected with spray nozzle aperture 241, secondary mixedLiquid passes through aperture 241 and sprays atomization.
In the present embodiment, nipple top inner surface is also provided with oblique guiding gutter 243, guiding gutter 243 and spraying sprayMouth aperture 241 is connected in the way of tangent, and the mixture in second chamber tangentially flows to aperture 241 along guiding gutter 243, during ejectionForm helical flow, there is more preferable spray effect.
After spray nozzle 24, support 26 and collet 25 are connected, it is placed in outward appearance 20 fixing.
Embodiment 3
Multicomponent pharmaceutical mixing sprayer of the present invention also includes medicine glass perforator 3.
With reference to Fig. 9 to Figure 11, medicine glass perforator includes medicine glass 31 and medicine glass support 30, and medicine glass 31 is by the card positioned at bottomFastener 34 is detachably connected with the fixing hole 35 of medicine glass support 30.
This embodiment is provided with two medicine glasses 31 of one end open, and the opening direction of medicine glass 31 is identical, and medicine glass 31 is hollowStructure, is equipped with the puncture needle 34 puncturing medicine bottle top cement plug in the cup bottom of medicine glass, puncture needle 34 is the hollow structure of both ends open,Puncture needle 34 bottom is provided with imbibition passage 311, and puncture needle 34 is connected with imbibition passage 311, and imbibition passage 311 props up with positioned at medicine glassHorizontal medicine circulation duct (not shown) connection on frame 30.
Medicine glass support 30 is provided with the first connector 331 and is used for being connected to drug component syringe, and is provided with second evenFitting 332 is used for being connected to air syringe, and the end of described connector is provided with interface channel, the company of the first connector 331Connect passage end and connect horizontal medicinal fluid pipeline, the other end is used for being connected to syringe internal cavities.
Described horizontal medicine circulation duct one end connects imbibition passage 311, and the other end extends internally, and is communicated to connector endThe interface channel in portion.
With reference to Figure 11, it is additionally provided with screw thread inside medicine glass 31, this medicine glass perforator is detachably connected with medicine bottle by screw thread, preventDuring only inhaling medicine, medicine bottle drops.
It is provided with air intake 32, interface channel one end of the second connector 332 is used for connecting air between two medicine glasses 31Syringe 12, the other end connects air by air intake 32.In the present embodiment, in air intake 32 and the second connector 332Between be additionally provided with drainage screen 320, this drainage screen 320 can be physical filtering or can also be subsidiary sterilizing function.
In the present embodiment, in the passage being formed between air intake and the second connector 332, it is provided with placement drainage screen 320Chamber 301, chamber 301 can be in medicine glass support 30.Or, connect between medicine glass 31, junction starts air such as mouth32, drainage screen 320 and chamber 301 can also be in the junction of cavity entrance 32 lower section.
Medicine glass 30 bottom is provided with annular protrusion 312 around imbibition passage 311, and medicine glass support 30 is provided with and annular protrusion 312The cannelure 302 of cooperation, when medicine glass 31 is connected with medicine glass support 30, annular protrusion 312 inserts the cannelure 302 of medicine glass support 30Interior, to fix this medicine glass perforator.
When drawing medicinal liquid using this medicine glass perforator, place a piece of drainage screen 320 in chamber 301, medicine glass is passed through positionIt is detachably connected in the fastener 34 of its bottom and the snap ring 35 of medicine glass support 30, now annular protrusion 312 is inserted into cannelureIn 302.
During use, the first connection end 331 of medicine glass support 30 is connected to the head end of drug component syringe 11, second evenConnect the head end that end 332 is connected to air syringe 12；Can be similar to the connected mode of nebulizer in above-described embodiment 1 and 2.
By the medicine bottle of different component as in different medicine glasses 31, puncture needle 310 punctures the plug of medicine bottle, pulls out noteThe piston of emitter, then medicinal liquid and air pass through different passages and enter in corresponding syringe.
Embodiment 4
With reference to embodiment 1, in the case that different component medicine allows to mix in advance, it is possible to use only a drug componentSyringe and an air syringe, now, the medicine in drug component syringe can be various ingredients, can be unevenMixing.With reference to the mode of embodiment 1, medicinal mixture is pushed together with air mixing chamber, equally, the present embodiment can carryHigh mixed effect and spray effect.
Similar, the above embodiment of the present invention can also be only used for spraying, and non-mixed, the spray of such as single medicine componentMist.
Above the specific embodiment of the present invention is described in detail, but it has been intended only as example, the present invention has not limitedIt is formed on particular embodiments described above.To those skilled in the art, any equivalent modifications that the present invention is carried out andSubstitute also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention andModification, all should cover within the scope of the invention.