技术领域technical field
本发明属于医疗器械技术领域，涉及一种用于急、慢性肝功能衰竭等疾病的新型肝功能支持系统，即一种可实现多种吸附剂的再生与重复利用，增加血液净化系统毒素清除的种类，维持体内电解质平衡，消除人体水肿，提高血液净化效率的生物相容性好、能有效防止医用白蛋白和吸附剂进入人体的新型多功能再生血液净化系统的设计。The invention belongs to the technical field of medical devices, and relates to a new type of liver function support system for acute and chronic liver failure and other diseases, that is, a system that can realize the regeneration and reuse of various adsorbents and increase the removal of toxins in the blood purification system Species, maintaining electrolyte balance in the body, eliminating human edema, improving blood purification efficiency, good biocompatibility, and the design of a new multifunctional regenerative blood purification system that can effectively prevent medical albumin and adsorbents from entering the human body.
背景技术Background technique
肝功能衰竭已成为威胁我国人民健康的危重疾病，其诱因主要有免疫伤害、病毒入侵、药物滥用和长期酗酒等。肝移植是目前治疗肝衰竭最有效的方式，但由于肝源匮乏、匹配困难、等待供体时间漫长及治疗费用昂贵而限制其临床应用，因此迫切需要肝功能支持系统医疗设备的发展。多功能再生血液净化系统（ALSS）作为一种肝功能替代装置，能暂时辅助病变的肝脏（清除多种有害物质、执行部分代谢功能），直至自体肝脏功能恢复或进行肝脏移植，故而成为肝衰竭治疗的有效方法之一。多功能再生血液净化系统通常基于血浆置换、血液透析、血液过滤、血浆透析过滤、血液灌流、白蛋白透析、吸附等技术去除血液中毒素。当前，多功能再生血液净化系统主要有单循环白蛋白透析系统（SPAD）、分子吸附再循环系统（MARS）和普罗米修斯（Prometheus）等。这些系统能清除不溶于水的、与蛋白质结合的毒素，但都存在各自的问题，例如：MARS系统毒素的清除效率不仅受吸附剂用量和种类的影响，同时也受到纤维膜传质效率的限制；Prometheus系统人体自身的白蛋白损失大；SPAD系统需用大量人白蛋白致使治疗成本高昂。Liver failure has become a critical disease that threatens the health of our people, and its main causes are immune injury, virus invasion, drug abuse and long-term alcoholism. Liver transplantation is currently the most effective way to treat liver failure, but its clinical application is limited due to lack of liver sources, difficulty in matching, long waiting time for donors, and high treatment costs. Therefore, the development of medical equipment for liver function support systems is urgently needed. As a liver function replacement device, the multifunctional regenerative blood purification system (ALSS) can temporarily assist the diseased liver (remove a variety of harmful substances and perform some metabolic functions) until the autologous liver function is restored or liver transplantation is performed, so it becomes liver failure. One of the effective methods of treatment. Multifunctional regenerative blood purification systems are usually based on plasma exchange, hemodialysis, hemofiltration, plasma diafiltration, hemoperfusion, albumin dialysis, adsorption and other technologies to remove toxins from the blood. Currently, multifunctional regenerative blood purification systems mainly include single-cycle albumin dialysis system (SPAD), molecular adsorption recirculation system (MARS), and Prometheus. These systems can remove toxins that are insoluble in water and bound to proteins, but they all have their own problems. For example, the removal efficiency of toxins in the MARS system is not only affected by the amount and type of adsorbent, but also limited by the mass transfer efficiency of the fiber membrane. ; The Prometheus system has a large loss of human albumin; the SPAD system requires a large amount of human albumin, resulting in high treatment costs.
肝支持系统的基本原理是通过一个装置暂时或完全替代严重病变的肝脏部分或全部功能，主要是去除患者体内由于肝脏功能丧失而累积的可促使肝脏组织无法再生、硬化以致癌变的代谢物毒素。当前，通常采用透析方式清除水溶性的代谢物毒素，采用吸附方式去除不溶于水的、与白蛋白结合的代谢物毒素。但是，不合理的设计可能导致自身白蛋白的损耗、吸附微粒进入人体、吸附剂利用率低、自身白蛋白被外来白蛋白污染等，从而导致不仅肝支持系统价格昂贵，而且可造成毒素清除效率低及安全性隐患。The basic principle of the liver support system is to use a device to temporarily or completely replace part or all of the liver function in severe disease, mainly to remove the metabolite toxins accumulated in the patient's body due to the loss of liver function, which can cause liver tissue to fail to regenerate, harden and become cancerous. Currently, dialysis is usually used to remove water-soluble metabolite toxins, and adsorption is used to remove water-insoluble, albumin-bound metabolite toxins. However, unreasonable design may lead to loss of self-albumin, adsorption of particles into the human body, low utilization rate of adsorbent, contamination of self-albumin by foreign albumin, etc., which will not only lead to expensive liver support system, but also cause toxin removal efficiency Low and security risks.
发明内容Contents of the invention
本发明的目的是提供一种多功能再生血液净化系统。The object of the present invention is to provide a multifunctional regenerative blood purification system.
一种多功能再生血液净化系统包括血液净化机构、透析液补充机构、毒素吸附机构9；A multifunctional regenerative blood purification system includes a blood purification mechanism, a dialysate replenishment mechanism, and a toxin adsorption mechanism 9;
所述血液净化机构包括串联的第一高通量透析器71和第二高通量透析器72；The blood purification mechanism includes a first high-flux dialyzer 71 and a second high-flux dialyzer 72 connected in series;
所述第一高通量透析器71的第一血液进口711依次串联着第一动脉壶61、血泵11和输入单向阀211，输入单向阀211的进口为血液净化机构的进口；The first blood inlet 711 of the first high-flux dialyzer 71 is sequentially connected in series with the first arterial jug 61, the blood pump 11 and the input one-way valve 211, and the inlet of the input one-way valve 211 is the inlet of the blood purification mechanism;
第一高通量透析器71的白蛋白溶液出口713通过依次串联的第一超滤泵13、第一吸毒单向阀25和第二动脉壶62连通着毒素吸附机构9的进口，第一高通量透析器71的白蛋白溶液进口712通过串联的第二动力泵14连通着第一白蛋白溶液接口；The albumin solution outlet 713 of the first high-flux dialyzer 71 is connected to the inlet of the toxin adsorption mechanism 9 through the first ultrafiltration pump 13, the first drug intake check valve 25 and the second arterial pot 62 connected in series in sequence. The albumin solution inlet 712 of the flux dialyzer 71 is connected to the first albumin solution interface through the second power pump 14 connected in series;
第一高通量透析器71的第一血液出口714和第二高通量透析器72的第二血液进口721之间串联着第三动脉壶63；A third arterial jug 63 is connected in series between the first blood outlet 714 of the first high-flux dialyzer 71 and the second blood inlet 721 of the second high-flux dialyzer 72;
所述第二高通量透析器72的透析液出口722通过依次串联的第二超滤泵15和第二废液单向阀210连接着废液接口；第二高通量透析器72的第二血液出口723依次串联着静脉壶64、输出单向阀212；The dialysate outlet 722 of the second high-throughput dialyzer 72 is connected to the waste liquid interface through the second ultrafiltration pump 15 and the second waste liquid one-way valve 210 connected in series; The second blood outlet 723 is connected in series with the venous pot 64 and the output one-way valve 212 in sequence;
其中输入单向阀211的入口为所述系统的输入端，输出单向阀212的出口为所述系统的输出端；Wherein the inlet of the input check valve 211 is the input end of the system, and the outlet of the output check valve 212 is the output end of the system;
所述透析液补充机构包括第一动力泵12、透析单向阀21、置换单向阀22和净化单向阀23；透析单向阀21和置换单向阀22并联在第一动力泵12的进口，透析单向阀21的进口连通着透析液袋81，置换单向阀22的进口连通着置换液袋82；净化单向阀23的出口为透析液补充机构的出口，透析液补充机构的出口或连通着第三动脉壶63的进口或连通着静脉壶64的进口；The dialysate replenishing mechanism includes a first power pump 12, a dialysis one-way valve 21, a replacement one-way valve 22 and a purification one-way valve 23; Inlet, the inlet of the dialysis check valve 21 is connected to the dialysate bag 81, the inlet of the replacement check valve 22 is connected to the replacement bag 82; the outlet of the purification check valve 23 is the outlet of the dialysate replenishment mechanism, and the dialysate replenishment mechanism The outlet or the inlet connected to the third arterial jug 63 or the inlet connected to the venous jug 64;
所述毒素吸附机构9包括串联的第二吸毒单向阀26、碳吸附柱911和树脂吸附柱912，串联的碳吸附柱911和树脂吸附柱912位于振荡机构5上；其中碳吸附柱911的进口端为毒素吸附机构9的进口，树脂吸附柱912的出口端为毒素吸附机构9的出口，形成一种毒素吸附模式；The toxin adsorption mechanism 9 includes the second drug absorption check valve 26 connected in series, the carbon adsorption column 911 and the resin adsorption column 912, and the carbon adsorption column 911 and the resin adsorption column 912 connected in series are located on the oscillation mechanism 5; wherein the carbon adsorption column 911 The inlet end is the inlet of the toxin adsorption mechanism 9, and the outlet end of the resin adsorption column 912 is the outlet of the toxin adsorption mechanism 9, forming a toxin adsorption mode;
毒素吸附机构9的进口处设有第二动脉壶62，第二动脉壶62的第一进口通过解毒单向阀24连通第一动力泵12的出口，第二动脉壶62的第二进口连通着第一吸毒单向阀25的出口；The entrance of the toxin adsorption mechanism 9 is provided with a second arterial jug 62, the first inlet of the second arterial jug 62 is connected to the outlet of the first power pump 12 through the detoxification check valve 24, and the second inlet of the second arterial jug 62 is connected to the The outlet of the first drug intake check valve 25;
毒素吸附机构9的出口通过第三吸毒单向阀29连通着第二白蛋白溶液接口或通过第一废液单向阀28连通着废液池16；The outlet of the toxin adsorption mechanism 9 is connected to the second albumin solution interface through the third drug absorption one-way valve 29 or connected to the waste liquid pool 16 through the first waste liquid one-way valve 28;
工作时，第一白蛋白溶液接口和第二白蛋白溶液接口分别连通白蛋白容器10的两个端口；When working, the first albumin solution interface and the second albumin solution interface are respectively connected to the two ports of the albumin container 10;
所述输入单向阀211、血泵11、第一动脉壶61、第一高通量透析器71、第三动脉壶63、第二高通量透析器72、静脉壶64和输出单向阀212构成血液循环机构；The input one-way valve 211, the blood pump 11, the first arterial jug 61, the first high-flux dialyzer 71, the third arterial jug 63, the second high-flux dialyzer 72, the venous jug 64 and the output one-way valve 212 constituting a blood circulation mechanism;
所述第一高通量透析器71、第一超滤泵13、第一吸毒单向阀25和第二动脉壶62、毒素吸附机构9、第三吸毒单向阀29、白蛋白溶液容器10、第二动力泵14构成白蛋白循环机构；The first high-flux dialyzer 71, the first ultrafiltration pump 13, the first drug intake one-way valve 25 and the second arterial jug 62, the toxin adsorption mechanism 9, the third drug intake one-way valve 29, and the albumin solution container 10 , The second power pump 14 constitutes an albumin circulation mechanism;
所述透析单向阀21、透析液袋81、置换单向阀22、置换液袋82、第一动力泵12、解毒单向阀24、第二动脉壶62、毒素吸附机构9、第一废液单向阀28、废液池16构成吸附剂和白蛋白再生机构；The dialysis check valve 21, the dialysate bag 81, the replacement check valve 22, the replacement bag 82, the first power pump 12, the detoxification check valve 24, the second arterial jug 62, the toxin adsorption mechanism 9, the first waste The liquid one-way valve 28 and the waste liquid pool 16 constitute the regeneration mechanism of adsorbent and albumin;
所述系统实现以下操作：The system implements the following operations:
用于清除血液中毒素时，血液循环机构、血液净化机构、透析液补充机构、毒素吸附机构9和白蛋白循环机构工作，吸附剂和白蛋白再生机构停止工作；第二动脉壶62的第一进口关闭，第二动脉壶62的第二进口接通；清除与白蛋白结合类毒素时，所述第一高通量透析器71的第一白蛋白溶液接口和毒素吸附机构9出口的第二白蛋白溶液接口分别连通着白蛋白容器10；清除清除血液中不与白蛋白结合类毒素和多余的水分时，透析液补充机构工作，所述第二高通量透析器的第二血液入口连通着第三动脉壶63的出口，第二高通量透析器72的透析液出口连通废液池16；When used to remove toxins in the blood, the blood circulation mechanism, the blood purification mechanism, the dialysate replenishment mechanism, the toxin adsorption mechanism 9 and the albumin circulation mechanism work, and the adsorbent and albumin regeneration mechanism stop working; the first arterial pot 62 The inlet is closed, and the second inlet of the second arterial jug 62 is connected; when the toxoid bound to albumin is removed, the first albumin solution interface of the first high-flux dialyzer 71 and the second outlet of the toxin adsorption mechanism 9 The albumin solution interface is respectively connected to the albumin container 10; when the toxoid and excess water not bound to the albumin in the blood are removed, the dialysate replenishment mechanism works, and the second blood inlet of the second high-flux dialyzer is connected to Next to the outlet of the third arterial jug 63, the dialysate outlet of the second high-flux dialyzer 72 is connected to the waste liquid pool 16;
其中，用于血液循环时，人体血液经输入单向阀211输入系统，经输出单向阀212输出系统后流回人体；补充透析液时，透析液接口和置换液接口分别连接透析液袋81和置换液袋82，透析液补充机构的出口有三种连接模式，单独连通着第三动脉壶63的进口形成第一种透析液补充模式，单独连通着静脉壶64的进口形成第二种透析液补充模式，还可以同时连通着第三动脉壶63的进口和静脉壶64的进口形成第三种透析液补充模式；毒素吸附时，所述毒素吸附机构9的入口和出口分别接通着第二动脉壶62的出口和白蛋白容器10第二白蛋白溶液接口；Wherein, when used for blood circulation, human blood is input into the system through the input check valve 211, and then flows back to the human body after being output through the output check valve 212; And the replacement fluid bag 82, the outlet of the dialysate replenishment mechanism has three connection modes, the inlet of the third arterial pot 63 is connected separately to form the first dialysate replenishment mode, and the inlet of the venous pot 64 is independently connected to form the second dialysate Supplementary mode can also be connected to the inlet of the third arterial jug 63 and the inlet of the venous jug 64 to form the third dialysate replenishment mode; during toxin adsorption, the inlet and outlet of the toxin adsorption mechanism 9 are respectively connected to the second The outlet of the arterial jug 62 and the second albumin solution interface of the albumin container 10;
用于吸附剂和白蛋白再生时，血液循环机构、透析液补充机构、血液净化机构和白蛋白循环机构停止工作，毒素吸附机构9和吸附剂和白蛋白再生机构工作；所述第二动脉壶62的第二进口关闭，第二动脉壶62的第一进口打开；所述透析液接口和置换液接口分别连接透析液袋和置换液袋，毒素吸附机构9出口的第二白蛋白溶液接口关闭；毒素吸附机构9的出口通过单向阀28连通着废液池16；第二高通量透析器72的废液接口连通废液池16。When used for regeneration of adsorbent and albumin, the blood circulation mechanism, dialysate replenishment mechanism, blood purification mechanism and albumin circulation mechanism stop working, and the toxin adsorption mechanism 9 and the regeneration mechanism of adsorbent and albumin work; the second arterial jug The second inlet of 62 is closed, and the first inlet of the second arterial jug 62 is opened; the dialysate interface and the replacement fluid interface are respectively connected to the dialysate bag and the replacement fluid bag, and the second albumin solution interface at the outlet of the toxin adsorption mechanism 9 is closed The outlet of the toxin adsorption mechanism 9 is connected to the waste liquid pool 16 through the one-way valve 28;
进一步限定的技术方案如下：Further defined technical solutions are as follows:
所述血泵11、第一动力泵12、第一超滤泵13、第二动力泵14，第二超滤泵15均为医用蠕动泵。The blood pump 11, the first power pump 12, the first ultrafiltration pump 13, the second power pump 14, and the second ultrafiltration pump 15 are all medical peristaltic pumps.
所述透析单向阀21、置换单向阀22、净化单向阀23、解毒单向阀24、第一吸毒单向阀25、第二吸毒单向阀26、旁路单向阀27、第一废液单向阀28、第三吸毒单向阀29、第二废液单向阀210、输入单向阀211、输出单向阀212均为医用单向阀。The dialysis one-way valve 21, the replacement one-way valve 22, the purification one-way valve 23, the detoxification one-way valve 24, the first drug taking one-way valve 25, the second drug taking one-way valve 26, the bypass one-way valve 27, the second one-way valve A waste liquid one-way valve 28, a third drug inhalation one-way valve 29, a second waste liquid one-way valve 210, an input one-way valve 211, and an output one-way valve 212 are all medical one-way valves.
所述血泵11的进口设有第一抗凝剂供给器件31，第二高通量透析器72的出口设有第二抗凝剂供给器件32；所述第一抗凝剂供给器件31和第二抗凝剂供给器件32均为注射器。The inlet of the blood pump 11 is provided with a first anticoagulant supply device 31, and the outlet of the second high-flux dialyzer 72 is provided with a second anticoagulant supply device 32; the first anticoagulant supply device 31 and The second anticoagulant supply devices 32 are all syringes.
所述毒素吸附机构9的进口和出口之间串联着旁路单向阀27，旁路单向阀27进口端为毒素吸附机构9的进口，旁路单向阀27的出口端为毒素吸附机构9的出口，形成另一种毒素吸附模式。A bypass check valve 27 is connected in series between the inlet and outlet of the toxin adsorption mechanism 9, the inlet end of the bypass check valve 27 is the inlet of the toxin adsorption mechanism 9, and the outlet end of the bypass check valve 27 is the toxin adsorption mechanism 9, forming another toxin adsorption mode.
所述第一动力泵12的出口串联着第一加热机构41，所述第二动力泵14的出口串联着第二加热机构42；所述第一加热机构41和第二加热机构42均为医用血液加热机构。The outlet of the first power pump 12 is connected in series with the first heating mechanism 41, and the outlet of the second power pump 14 is connected in series with the second heating mechanism 42; the first heating mechanism 41 and the second heating mechanism 42 are both medical Blood heating mechanism.
所述振荡器件5为医用振荡器。The oscillating device 5 is a medical oscillator.
所述第一动脉壶61、第二动脉壶62、第三动脉壶63、静脉壶64、毒素吸附机构9的出口和第二高通量透析器72的透析液出口722上分别设有压力传感器；所述第二动脉壶62和静脉壶64上分别设有液面传感器；所述透析液袋81、置换液袋82、白蛋白容器10和废液池16上分别设有重量传感器；所述第一高通量透析器71的白蛋白溶液出口713和第二高通量透析器72的透析液出口722上分别设有血漏传感器；所述第一加热机构41的出口和第二加热机构42的出口分别设有温度传感器；所述输出单向阀212的进口处设有气泡传感器。The outlets of the first arterial jug 61, the second arterial jug 62, the third arterial jug 63, the venous jug 64, the toxin adsorption mechanism 9, and the dialysate outlet 722 of the second high-flux dialyzer 72 are respectively provided with pressure sensors The second arterial jug 62 and the venous jug 64 are respectively provided with a liquid level sensor; the dialysate bag 81, the replacement fluid bag 82, the albumin container 10 and the waste liquid pool 16 are respectively provided with a weight sensor; The albumin solution outlet 713 of the first high-flux dialyzer 71 and the dialysate outlet 722 of the second high-flux dialyzer 72 are respectively provided with a blood leakage sensor; the outlet of the first heating mechanism 41 and the second heating mechanism The outlets of 42 are respectively provided with temperature sensors; the inlet of the output check valve 212 is provided with air bubble sensors.
所述碳吸附柱911为医用碳吸附柱，所述树脂吸附柱912为医用树脂吸附柱。The carbon adsorption column 911 is a medical carbon adsorption column, and the resin adsorption column 912 is a medical resin adsorption column.
所述第一动脉壶61、第二动脉壶62、第三动脉壶63均为医用动脉壶，静脉壶64为医用静脉壶，第一高通量透析器71和第二高通量透析器72均为医用高通量透析器。The first arterial jug 61, the second arterial jug 62, and the third arterial jug 63 are all medical arterial jugs, the venous jug 64 is a medical venous jug, the first high-flux dialyzer 71 and the second high-flux dialyzer 72 All are medical high-flux dialyzers.
本发明系统可减少自身白蛋白的损失，防止外来白蛋白污染，实现多种吸附剂的再生、重复和充分利用，提高现有吸附剂使用效率和系统毒素清除效率，避免血液与吸附剂接触而导致的免疫问题，防止可能的吸附剂颗粒进入人体，以及有效实现电解质平衡，排出血液中多余水分和人体中多余体液（水肿），节约成本，缩短治疗时间，减少系统损耗，增加系统安全性和实现个性化治疗。The system of the present invention can reduce the loss of its own albumin, prevent foreign albumin pollution, realize the regeneration, repetition and full utilization of various adsorbents, improve the use efficiency of existing adsorbents and the removal efficiency of system toxins, and avoid contact between blood and adsorbents. The immune problems caused by it can prevent possible adsorbent particles from entering the human body, and effectively achieve electrolyte balance, discharge excess water in the blood and excess body fluid (edema) in the human body, save costs, shorten treatment time, reduce system loss, increase system safety and Realize personalized treatment.
本发明的有益技术效果体现在以下方面：Beneficial technical effect of the present invention is embodied in the following aspects:
1、本发明系统工作时，吸附剂不与血液直接接触，减少对血细胞的损伤以及对血液的污染，同时，增加系统的生物相容性。1. When the system of the present invention is working, the adsorbent does not directly contact with blood, which reduces damage to blood cells and pollution to blood, and at the same time increases the biocompatibility of the system.
2、本系统采用吸附剂再生系统，实现吸附剂的多次重复利用，提高吸附剂的利用率，减少吸附剂大量耗费，降低系统损耗，节省成本。2. The system adopts the adsorbent regeneration system to realize the repeated use of the adsorbent, improve the utilization rate of the adsorbent, reduce the large consumption of the adsorbent, reduce the loss of the system, and save the cost.
3、本系统利用纤维膜将血液模块与白蛋白模块隔开，阻止吸附剂微颗粒进入人体，避免吸附剂微颗粒对人体的伤害。3. The system uses fiber membranes to separate the blood module from the albumin module, preventing the adsorbent microparticles from entering the human body and avoiding the damage of the adsorbent microparticles to the human body.
4、本系统采用白蛋白循环系统，减少自身白蛋白的损失，白蛋白循环系统中的白蛋白不进入人体，从而避免外来白蛋白对自身白蛋白的污染。4. This system adopts the albumin circulation system to reduce the loss of self-albumin, and the albumin in the albumin circulation system does not enter the human body, thereby avoiding the pollution of foreign albumin to self-albumin.
5、本系统采用连续性血液净化，能快速平衡人体电解质浓度，快速清除血液中水溶性中、小分子毒素，有效去除患者体内过量的水从而消除水肿。5. The system adopts continuous blood purification, which can quickly balance the electrolyte concentration of the human body, quickly remove water-soluble medium and small molecule toxins in the blood, and effectively remove excess water in the patient's body to eliminate edema.
6、本系统采用连续性血液净化，能快速清除血液中水溶性中、小分子毒素，能有效去除患者体内过量的水，从而消除水肿。6. The system adopts continuous blood purification, which can quickly remove water-soluble medium and small molecular toxins in the blood, and can effectively remove excess water in the patient's body, thereby eliminating edema.
7、本系统通过结合监控装置，能实现监控整个系统的运行，为了实现远程控制奠定了基础。7. The system can monitor the operation of the whole system by combining the monitoring device, which lays the foundation for remote control.
8、本系统采用透析液补充（即血液滤过）和血液透析自动切换模式，可避免系统运行停机和实现个性化治疗。8. The system adopts dialysate replenishment (ie hemofiltration) and hemodialysis automatic switching mode, which can avoid system shutdown and realize personalized treatment.
附图说明Description of drawings
图1为本发明系统工作示意图。Fig. 1 is a working diagram of the system of the present invention.
图2为本发明毒素吸附机构示意图，91毒素吸附模式，92无毒素吸附模式。Fig. 2 is a schematic diagram of the toxin adsorption mechanism of the present invention, 91 in the toxin adsorption mode, and 92 in the non-toxin adsorption mode.
图3为本发明血液净化机构B1前稀释模式示意图。Fig. 3 is a schematic diagram of the pre-dilution mode of the blood purification mechanism B1 of the present invention.
图4为本发明血液净化机构B2后稀释模式示意图。Fig. 4 is a schematic diagram of the post-dilution mode of the blood purification mechanism B2 of the present invention.
图5为本发明吸附剂和白蛋白再生时系统工作示意图。Fig. 5 is a schematic diagram of the system working when the adsorbent and albumin of the present invention are regenerated.
上图中序号：血泵11、第一动力泵12、第一超滤泵13、第二动力泵14、第二超滤泵15、透析单向阀21、置换单向阀22、净化单向阀23、解毒单向阀24、第一吸毒单向阀25、第二吸毒单向阀26、旁路单向阀27、第一废液单向阀28、第三吸毒单向阀29、第二废液单向阀210、输入单向阀211、输出单向阀212、第一抗凝剂供给器件31、第二抗凝剂供给器件32、第一加热机构41、第二加热机构42、振荡机构5、第一动脉壶61、第二动脉壶62、第三动脉壶63、静脉壶64、第一高通量透析器71、第二高通量透析器72、第一血液进口711、白蛋白溶液进口712、白蛋白溶液出口713、第一血液出口714、第二血液进口721、透析液出口722、第二血液出口723、透析液袋81、置换液袋82、毒素吸附机构9、碳吸附柱911、树脂吸附柱912、白蛋白容器10、废液池16。Serial numbers in the above picture: blood pump 11, first power pump 12, first ultrafiltration pump 13, second power pump 14, second ultrafiltration pump 15, dialysis one-way valve 21, replacement one-way valve 22, purification one-way Valve 23, detoxification check valve 24, first drug intake check valve 25, second drug intake check valve 26, bypass check valve 27, first waste liquid check valve 28, third drug intake check valve 29, the first Two waste liquid one-way valve 210, input one-way valve 211, output one-way valve 212, first anticoagulant supply device 31, second anticoagulant supply device 32, first heating mechanism 41, second heating mechanism 42, Oscillating mechanism 5, first arterial jug 61, second arterial jug 62, third arterial jug 63, venous jug 64, first high-flux dialyzer 71, second high-flux dialyzer 72, first blood inlet 711, Albumin solution inlet 712, albumin solution outlet 713, first blood outlet 714, second blood inlet 721, dialysate outlet 722, second blood outlet 723, dialysate bag 81, replacement fluid bag 82, toxin adsorption mechanism 9, Carbon adsorption column 911 , resin adsorption column 912 , albumin container 10 , waste liquid pool 16 .
具体实施方式detailed description
下面结合附图，通过实施例对本发明作进一步地说明。The present invention will be further described through the embodiments below in conjunction with the accompanying drawings.
参见图1，一种多功能再生血液净化系统包括血液净化机构、透析液补充机构、毒素吸附机构9。Referring to FIG. 1 , a multifunctional regenerative blood purification system includes a blood purification mechanism, a dialysate replenishment mechanism, and a toxin adsorption mechanism 9 .
血液净化机构包括串联的第一高通量透析器71和第二高通量透析器72，第一高通量透析器71和第二高通量透析器72均为医用高通量透析器。The blood purification mechanism includes a first high-flux dialyzer 71 and a second high-flux dialyzer 72 connected in series, both of which are medical high-flux dialyzers.
第一高通量透析器71的第一血液进口711依次串联着第一动脉壶61、血泵11和输入单向阀211，输入单向阀211的进口为血液净化机构的进口。The first blood inlet 711 of the first high-flux dialyzer 71 is sequentially connected in series with the first arterial jug 61 , the blood pump 11 and the input one-way valve 211 , and the inlet of the input one-way valve 211 is the inlet of the blood purification mechanism.
第一高通量透析器71的白蛋白溶液出口713通过依次串联的第一超滤泵13、第一吸毒单向阀25和第二动脉壶62连通着毒素吸附机构9的进口，第一高通量透析器71的白蛋白溶液进口712通过串联的第二动力泵14连通着第一白蛋白溶液接口。The albumin solution outlet 713 of the first high-flux dialyzer 71 is connected to the inlet of the toxin adsorption mechanism 9 through the first ultrafiltration pump 13, the first drug intake check valve 25 and the second arterial pot 62 connected in series in sequence. The albumin solution inlet 712 of the flux dialyzer 71 is connected to the first albumin solution interface through the second power pump 14 connected in series.
第一高通量透析器71的第一血液出口714和第二高通量透析器72的第二血液进口721之间串联着第三动脉壶63。A third arterial jug 63 is connected in series between the first blood outlet 714 of the first high-flux dialyzer 71 and the second blood inlet 721 of the second high-flux dialyzer 72 .
第二高通量透析器72的透析液出口722通过依次串联的第二超滤泵15和第二废液单向阀210连接着废液接口；第二高通量透析器72的第二血液出口723依次串联着静脉壶64、输出单向阀212。The dialysate outlet 722 of the second high-flux dialyzer 72 is connected to the waste liquid interface through the second ultrafiltration pump 15 and the second waste liquid check valve 210 connected in series in sequence; the second blood of the second high-flux dialyzer 72 The outlet 723 is connected in series with the venous pot 64 and the output one-way valve 212 in sequence.
其中输入单向阀211的入口为多功能再生血液净化系统的输入端，输出单向阀212的出口为多功能再生血液净化系统的输出端。The inlet of the input one-way valve 211 is the input end of the multifunctional regenerative blood purification system, and the outlet of the output one-way valve 212 is the output end of the multifunctional regenerative blood purification system.
参见图3，透析液补充机构包括第一动力泵12、透析单向阀21、置换单向阀22和净化单向阀23。透析单向阀21和置换单向阀22并联在第一动力泵12的进口，透析单向阀21的进口连通着透析液袋81，置换单向阀22的进口连通着置换液袋82；净化单向阀23的出口为透析液补充机构的出口，透析液补充机构的出口或连通着第三动脉壶63的进口或连通着静脉壶64的进口。Referring to FIG. 3 , the dialysate replenishment mechanism includes a first power pump 12 , a dialysis one-way valve 21 , a replacement one-way valve 22 and a purification one-way valve 23 . The dialysis one-way valve 21 and the replacement one-way valve 22 are connected in parallel at the inlet of the first power pump 12, the inlet of the dialysis one-way valve 21 is connected with the dialysate bag 81, and the inlet of the replacement one-way valve 22 is connected with the replacement fluid bag 82; The outlet of the one-way valve 23 is the outlet of the dialysate replenishment mechanism, and the outlet of the dialysate replenishment mechanism is either connected to the inlet of the third arterial jug 63 or connected to the inlet of the venous jug 64 .
参见图2，毒素吸附机构包括串联的第二吸毒单向阀26、碳吸附柱911和树脂吸附柱912，碳吸附柱911为医用碳吸附柱，树脂吸附柱912为医用树脂吸附柱。串联的碳吸附柱911和树脂吸附柱912位于振荡机构5上，振荡器件5为医用振荡器。碳吸附柱911的进口端为毒素吸附机构9的进口，树脂吸附柱912的出口端为毒素吸附机构9的出口，形成一种毒素吸附模式。Referring to Fig. 2, the toxin adsorption mechanism includes a second drug absorption one-way valve 26 connected in series, a carbon adsorption column 911 and a resin adsorption column 912, the carbon adsorption column 911 is a medical carbon adsorption column, and the resin adsorption column 912 is a medical resin adsorption column. The carbon adsorption column 911 and the resin adsorption column 912 connected in series are located on the oscillating mechanism 5, and the oscillating device 5 is a medical oscillator. The inlet end of the carbon adsorption column 911 is the inlet of the toxin adsorption mechanism 9, and the outlet end of the resin adsorption column 912 is the outlet of the toxin adsorption mechanism 9, forming a toxin adsorption mode.
另一种毒素吸附模式，即在毒素吸附机构9的进口和出口之间串联着旁路单向阀27，旁路单向阀27进口端为毒素吸附机构9的进口，旁路单向阀27的出口端为毒素吸附机构9的出口。Another toxin adsorption mode, that is, a bypass check valve 27 is connected in series between the inlet and outlet of the toxin adsorption mechanism 9, the inlet end of the bypass check valve 27 is the inlet of the toxin adsorption mechanism 9, and the bypass check valve 27 The outlet end of the outlet is the outlet of the toxin adsorption mechanism 9.
毒素吸附机构9的进口处设有第二动脉壶62，第二动脉壶62的第一进口通过解毒单向阀24连通第一动力泵12的出口，第二动脉壶62的第二进口连通着第一吸毒单向阀25的出口；毒素吸附机构9的出口通过第三吸毒单向阀29连通着第二白蛋白溶液接口或通过第一废液单向阀28连通着废液池16。The entrance of the toxin adsorption mechanism 9 is provided with a second arterial jug 62, the first inlet of the second arterial jug 62 is connected to the outlet of the first power pump 12 through the detoxification check valve 24, and the second inlet of the second arterial jug 62 is connected to the The outlet of the first drug inhalation one-way valve 25; the outlet of the toxin adsorption mechanism 9 is connected to the second albumin solution interface through the third drug inhalation one-way valve 29 or connected to the waste liquid pool 16 through the first waste liquid one-way valve 28 .
工作时，第一白蛋白溶液接口和第二白蛋白溶液接口分别连通白蛋白容器10的两个端口。During operation, the first albumin solution interface and the second albumin solution interface communicate with the two ports of the albumin container 10 respectively.
参见图3和图4，所述输入单向阀211、血泵11、第一动脉壶61、第一高通量透析器71、第三动脉壶63、第二高通量透析器72、静脉壶64和输出单向阀212构成血液循环机构；3 and 4, the input check valve 211, blood pump 11, first arterial jug 61, first high-flux dialyzer 71, third arterial jug 63, second high-flux dialyzer 72, vein The kettle 64 and the output one-way valve 212 constitute a blood circulation mechanism;
参见图1，所述第一高通量透析器71、第一超滤泵13、第一吸毒单向阀25和第二动脉壶62、毒素吸附机构9、第三吸毒单向阀29、白蛋白溶液容器10、第二动力泵14构成白蛋白循环机构；Referring to Fig. 1, the first high-throughput dialyzer 71, the first ultrafiltration pump 13, the first drug intake check valve 25 and the second arterial pot 62, the toxin adsorption mechanism 9, the third drug intake check valve 29, white The protein solution container 10 and the second power pump 14 constitute an albumin circulation mechanism;
参见图1，所述透析单向阀21、透析液袋81、置换单向阀22、置换液袋82、第一动力泵12、解毒单向阀24、第二动脉壶62、毒素吸附机构9、第一废液单向阀28、废液池16构成吸附剂和白蛋白再生机构。Referring to Fig. 1, the dialysis check valve 21, the dialysate bag 81, the replacement check valve 22, the replacement bag 82, the first power pump 12, the detoxification check valve 24, the second arterial jug 62, and the toxin adsorption mechanism 9 , the first waste liquid one-way valve 28, and the waste liquid pool 16 constitute an adsorbent and albumin regeneration mechanism.
所述血泵11、第一动力泵12、第一超滤泵13、第二动力泵14，第二超滤泵15均为医用蠕动泵。The blood pump 11, the first power pump 12, the first ultrafiltration pump 13, the second power pump 14, and the second ultrafiltration pump 15 are all medical peristaltic pumps.
所述透析单向阀21、置换单向阀22、净化单向阀23、解毒单向阀24、第一吸毒单向阀25、第二吸毒单向阀26、旁路单向阀27、第一废液单向阀28、第三吸毒单向阀29、第二废液单向阀210、输入单向阀211、输出单向阀212均为医用单向阀。The dialysis one-way valve 21, the replacement one-way valve 22, the purification one-way valve 23, the detoxification one-way valve 24, the first drug taking one-way valve 25, the second drug taking one-way valve 26, the bypass one-way valve 27, the second one-way valve A waste liquid one-way valve 28, a third drug inhalation one-way valve 29, a second waste liquid one-way valve 210, an input one-way valve 211, and an output one-way valve 212 are all medical one-way valves.
所述血泵11的进口设有第一抗凝剂供给器件31，第二高通量透析器72的出口设有第二抗凝剂供给器件32；第一抗凝剂供给器件31和第二抗凝剂供给器件32均为注射器。The inlet of the blood pump 11 is provided with a first anticoagulant supply device 31, and the outlet of the second high-flux dialyzer 72 is provided with a second anticoagulant supply device 32; the first anticoagulant supply device 31 and the second The anticoagulant supply devices 32 are all syringes.
第一动力泵12的出口串联着第一加热机构41，所述第二动力泵14的出口串联着第二加热机构42；所述第一加热机构41和第二加热机构42均为医用血液加热机构。The outlet of the first power pump 12 is connected in series with the first heating mechanism 41, and the outlet of the second power pump 14 is connected in series with the second heating mechanism 42; the first heating mechanism 41 and the second heating mechanism 42 are both medical blood heating mechanism.
所述第一动脉壶61、第二动脉壶62、第三动脉壶63、静脉壶64、毒素吸附机构9的出口和第二高通量透析器72的透析液出口722上分别设有压力传感器；所述第二动脉壶62和静脉壶64上分别设有液面传感器；所述透析液袋81、置换液袋82、白蛋白容器10和废液池16上分别设有重量传感器；所述第一高通量透析器71的白蛋白溶液出口713和第二高通量透析器72的透析液出口722上分别设有血漏传感器；所述第一加热机构41的出口和第二加热机构42的出口分别设有温度传感器；所述输出单向阀212的进口处设有气泡传感器。The outlets of the first arterial jug 61, the second arterial jug 62, the third arterial jug 63, the venous jug 64, the toxin adsorption mechanism 9, and the dialysate outlet 722 of the second high-flux dialyzer 72 are respectively provided with pressure sensors The second arterial jug 62 and the venous jug 64 are respectively provided with a liquid level sensor; the dialysate bag 81, the replacement fluid bag 82, the albumin container 10 and the waste liquid pool 16 are respectively provided with a weight sensor; The albumin solution outlet 713 of the first high-flux dialyzer 71 and the dialysate outlet 722 of the second high-flux dialyzer 72 are respectively provided with a blood leakage sensor; the outlet of the first heating mechanism 41 and the second heating mechanism The outlets of 42 are respectively provided with temperature sensors; the inlet of the output check valve 212 is provided with air bubble sensors.
所述第一动脉壶61、第二动脉壶62、第三动脉壶63均为医用动脉壶，静脉壶64为医用静脉壶。The first arterial jug 61 , the second arterial jug 62 and the third arterial jug 63 are all medical arterial jugs, and the venous jug 64 is a medical venous jug.
下面对本发明的工作原理分别说明。The working principle of the present invention will be described separately below.
用于清除血液中毒素的同时需要再生与毒素结合的白蛋白，参见图1，透析单向阀21、置换单向阀22、净化单向阀23、第一吸毒单向阀25、第二吸毒单向阀26、第三吸毒单向阀29、废液单向阀210、输入单向阀211和输出单向阀212打开，工作原理如下：It is used to remove toxins in the blood and needs to regenerate albumin combined with toxins, see Figure 1, dialysis check valve 21, replacement check valve 22, purification check valve 23, first drug intake check valve 25, second drug intake check valve The one-way valve 26, the third drug inhalation one-way valve 29, the waste liquid one-way valve 210, the input one-way valve 211 and the output one-way valve 212 are opened, and the working principle is as follows:
（1）人体血液流经输入单向阀211，随后经第一抗凝剂供给器件31补充抗凝剂后经血泵11泵入第一动脉壶61中，随后进入第一高通量透析器71，第一高通量透析器71膜过滤出的含毒素的溶液经第一超滤泵13流入第二动脉壶62。(1) Human blood flows through the input one-way valve 211 , then replenishes anticoagulant through the first anticoagulant supply device 31 , and then pumps it into the first arterial jug 61 through the blood pump 11 , and then enters the first high-flux dialyzer 71 , the toxin-containing solution filtered out by the membrane of the first high-flux dialyzer 71 flows into the second arterial jug 62 through the first ultrafiltration pump 13 .
（2）参见图2，随后含毒素的溶液经第二动脉壶62流入毒素吸附装置9，在使用碳吸附柱911和树脂吸附柱912的工作模式下吸附毒素溶液中的毒素；(2) Referring to Fig. 2, the toxin-containing solution then flows into the toxin adsorption device 9 through the second arterial pot 62, and the toxin in the toxin solution is adsorbed under the working mode of using the carbon adsorption column 911 and the resin adsorption column 912;
（3）被吸附去除毒素后的溶液经白蛋白容器10补充白蛋白后，通过第二动力泵14泵入第二加热机构42加热，使白蛋白溶液接近人体体温。(3) After the solution that has been adsorbed to remove toxins is supplemented with albumin through the albumin container 10, it is pumped into the second heating mechanism 42 by the second power pump 14 for heating, so that the albumin solution is close to the body temperature of the human body.
（4）通过重量传感器测量白蛋白容器10的重量，并通过调节第一超滤泵13和第二动力泵14控制白蛋白溶液的流量和第一高通量透析器71的超滤量。(4) Measure the weight of the albumin container 10 by a weight sensor, and control the flow rate of the albumin solution and the ultrafiltration volume of the first high-flux dialyzer 71 by adjusting the first ultrafiltration pump 13 and the second power pump 14 .
（5）补充白蛋白的溶液经第二加热机构42出口流入第一高通量透析器71的入口712。(5) The albumin-supplemented solution flows into the inlet 712 of the first high-flux dialyzer 71 through the outlet of the second heating mechanism 42 .
（6）参见图3，通过血液净化模块去除血液中多余的水分和水溶性的中、小分子毒素时，B1模式即前稀释模块，被吸附去除与白蛋白结合毒素的血液流入第三动脉壶63并通过透析液补充机构补充透析液，随后流入第二高通量透析器72，通过血液净化去除血液中多余的水分和水溶性的中、小分子毒素，随后除去毒素和多余水分的血液经静脉壶64和输出单向阀212流回人体；其中，通过重量传感器测量废液池16在给定时间内的重量变化以调节第二超滤泵15的流量。(6) See Figure 3. When excess water and water-soluble small and medium molecular toxins in the blood are removed through the blood purification module, the B1 mode is the pre-dilution module, and the blood that is adsorbed to remove the toxins bound to albumin flows into the third arterial jug 63 and the dialysate is supplemented by the dialysate replenishment mechanism, and then flows into the second high-flux dialyzer 72 to remove excess water and water-soluble small and medium molecular toxins in the blood through blood purification, and then the blood that removes the toxins and excess water passes through The venous pot 64 and the output one-way valve 212 flow back to the human body; wherein, the weight change of the waste liquid pool 16 within a given time is measured by a weight sensor to adjust the flow rate of the second ultrafiltration pump 15 .
实施例2Example 2
用于清除血液中毒素的同时需要再生与毒素结合的白蛋白，参见图1、图2和图4；It is used to remove toxins from the blood while regenerating albumin bound to toxins, see Figure 1, Figure 2 and Figure 4;
由图4可见，步骤（6）通过血液净化模块去除血液中多余的水分和水溶性的中、小分子毒素时，采用B2后稀释模式，被吸附或未被吸附去除与白蛋白结合毒素的血液也可经第三动脉壶63直接流入第二高通量透析器72去除血液中多余的水分和水溶性的中、小分子毒素，随后流入静脉壶64同时由透析液补充机构补充透析液。As can be seen from Figure 4, when step (6) removes excess water and water-soluble small and medium molecular toxins in the blood through the blood purification module, the B2 post-dilution mode is used to remove the blood that is adsorbed or not adsorbed toxins bound to albumin It can also directly flow into the second high-flux dialyzer 72 through the third arterial jug 63 to remove excess water and water-soluble medium and small molecule toxins in the blood, and then flow into the venous jug 64 while the dialysate is replenished by the dialysate replenishment mechanism.
其它步骤（1）、步骤（2）、步骤（3）、步骤（4）、步骤（5）同实施例1中。Other steps (1), step (2), step (3), step (4), and step (5) are the same as those in embodiment 1.
实施例3Example 3
用于清除血液中毒素的同时需要再生与毒素结合的白蛋白，参见图1、图2、图3和图4。When used to remove toxins from the blood, albumin bound to toxins needs to be regenerated, see Figure 1, Figure 2, Figure 3 and Figure 4.
由图3和图4可见，步骤（6）通过血液净化模块去除血液中多余的水分和水溶性的中、小分子毒素时，同时采用B1前稀释模式和B2后稀释模式，被吸附或未被吸附去除与白蛋白结合毒素的血液经第三动脉壶63并通过透析液补充机构补充透析液，随后流入第二高通量透析器72去除血液中多余的水分和水溶性的中、小分子毒素，随后流入静脉壶64同时由透析液补充机构补充透析液。It can be seen from Figure 3 and Figure 4 that when step (6) removes excess water and water-soluble small and medium molecule toxins in the blood through the blood purification module, B1 pre-dilution mode and B2 post-dilution mode are adopted at the same time, whether it is absorbed or not The blood that absorbs and removes toxins bound to albumin passes through the third arterial jug 63 and replenishes the dialysate through the dialysate replenishment mechanism, and then flows into the second high-flux dialyzer 72 to remove excess water and water-soluble small and medium molecular toxins in the blood , and then flow into the venous pot 64 while the dialysate is replenished by the dialysate replenishment mechanism.
其它步骤（1）、步骤（2）、步骤（3）、步骤（4）、步骤（5）同实施例1中。Other steps (1), step (2), step (3), step (4), and step (5) are the same as those in embodiment 1.
实施例4Example 4
用于仅净化血液，不需要再生与毒素结合的白蛋白时，参见图1、图2和图3，透析单向阀21、置换单向阀22、净化单向阀23、第一吸毒单向阀25、旁路单向阀27、第三吸毒单向阀29、废液单向阀210、输入单向阀211和输出单向阀212打开，工作原理如下：When it is only used to purify blood and does not need to regenerate albumin combined with toxins, see Figure 1, Figure 2 and Figure 3, the dialysis check valve 21, the replacement check valve 22, the purification check valve 23, the first drug use check valve Valve 25, bypass check valve 27, third drug intake check valve 29, waste liquid check valve 210, input check valve 211 and output check valve 212 are opened, and the working principle is as follows:
参见图2，经过实施例1中的步骤（1）后，当不需要回收与毒素结合的白蛋白时，步骤（2）随后含毒素的溶液经第二动脉壶62流入毒素吸附装置9，在毒素吸附装置9中串联着旁路单向阀27的工作模式下毒素溶液中的毒素未被吸附直接流过。Referring to Figure 2, after step (1) in Example 1, when it is not necessary to recover the albumin bound to the toxin, step (2) then the toxin-containing solution flows into the toxin adsorption device 9 through the second arterial pot 62, and in In the working mode in which the bypass check valve 27 is connected in series in the toxin adsorption device 9, the toxin in the toxin solution flows through without being adsorbed.
其它步骤（1）、步骤（3）、步骤（4）、步骤（5）、步骤（6）同实施例1。Other steps (1), step (3), step (4), step (5), and step (6) are the same as in embodiment 1.
实施例5Example 5
用于仅净化血液，不需要再生与毒素结合的白蛋白时，参见图1、图2、图3和图4，For purifying blood only, without regeneration of toxin-bound albumin, see Figure 1, Figure 2, Figure 3 and Figure 4,
本实施例中步骤（1）、步骤（3）、步骤（4）、步骤（5）、同实施例1，步骤（2）同实施例4，步骤（6）同实施例2。In this embodiment, step (1), step (3), step (4), and step (5) are the same as in embodiment 1, step (2) is the same as in embodiment 4, and step (6) is the same as in embodiment 2.
实施例6Example 6
用于仅净化血液，不需要再生与毒素结合的白蛋白时，参见图1、图2、图3和图4，For purifying blood only, without regeneration of toxin-bound albumin, see Figure 1, Figure 2, Figure 3 and Figure 4,
本实施例中步骤（1）、步骤（3）、步骤（4）、步骤（5）同实施例1，步骤（2）同实施例4中，步骤（6）同实施例3。In this embodiment, step (1), step (3), step (4), and step (5) are the same as in embodiment 1, step (2) is the same as in embodiment 4, and step (6) is the same as in embodiment 3.
实施例7Example 7
用于吸附剂和白蛋白再生时，参见图5。透析单向阀21、置换单向阀22、解毒单向阀24、单向阀28打开； For sorbent and albumin regeneration, see Figure 5. Dialysis check valve 21, replacement check valve 22, detoxification check valve 24, check valve 28 are opened;
透析液袋81和置换液袋82中的透析液经第一动力泵12作用流经第一加热机构41、第一吸毒单向阀24、第二动脉壶62进入毒素吸附装置5，经过置于振荡器件上的碳过滤柱911，碳吸附剂解吸附与白蛋白结合的毒素，之后溶液流入置于振荡器件上的树脂过滤柱912，树脂吸附剂解吸附与白蛋白结合的毒素，随后溶液经单向阀28流入废液池16，持续此项操作直到碳过滤柱911和树脂过滤柱912中的吸附剂上所吸附的毒素被洗涤干净，完成吸附剂和白蛋白再生操作。The dialysate in the dialysate bag 81 and the replacement bag 82 flows through the first heating mechanism 41, the first drug taking check valve 24, and the second arterial pot 62 through the first power pump 12 and enters the toxin adsorption device 5, and passes through the The carbon filter column 911 on the oscillating device, the carbon adsorbent desorbs the toxin bound to albumin, and then the solution flows into the resin filter column 912 placed on the oscillating device, the resin adsorbent desorbs the toxin bound to albumin, and then The solution flows into the waste liquid pool 16 through the one-way valve 28, and this operation continues until the toxins adsorbed on the adsorbents in the carbon filter column 911 and resin filter column 912 are washed clean, and the regeneration of the adsorbent and albumin is completed.
上述实施例1-3适用于净化血液的同时需要再生与毒素结合的白蛋白的情况，其步骤（1）-（5）相同，步骤（6）不同，可根据病人的病情选取施例1-3中的（6）。The above-mentioned examples 1-3 are applicable to the situation where it is necessary to regenerate the albumin combined with the toxin while purifying the blood. The steps (1)-(5) are the same, but the step (6) is different. Example 1- (6) of 3.
上述实施例4-6适用于仅净化血液，不需要再生与毒素结合的白蛋白的情况，其步骤（1）-（5）相同，步骤（6）不同，可根据病人的病情选取施例4-6中的（6）。The above-mentioned embodiments 4-6 are applicable to the situation where only the blood is purified, and the albumin combined with the toxin does not need to be regenerated. The steps (1)-(5) are the same, but the step (6) is different, and the embodiment 4 can be selected according to the patient's condition. -(6) of 6.
上述实施例7适用于回收与毒素结合的白蛋白。Example 7 above is suitable for recovery of toxin-bound albumin.
| Application Number | Priority Date | Filing Date | Title |
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| CN201610834013.8ACN106344985B (en) | 2016-09-20 | 2016-09-20 | A kind of multifunctional recycled blood purification system |
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| CN201610834013.8ACN106344985B (en) | 2016-09-20 | 2016-09-20 | A kind of multifunctional recycled blood purification system |
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| CN106344985Atrue CN106344985A (en) | 2017-01-25 |
| CN106344985B CN106344985B (en) | 2018-06-12 |
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| CN201610834013.8AActiveCN106344985B (en) | 2016-09-20 | 2016-09-20 | A kind of multifunctional recycled blood purification system |
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