技术领域technical field
本发明涉及医用检测装置，具体是一种可部分脱离的智能胶囊，通过吞食胶囊，检测胃部疾病。The invention relates to a medical detection device, in particular to a partially detachable intelligent capsule, which detects stomach diseases by swallowing the capsule.
背景技术Background technique
目前，临床医学上，胃部疾病的诊断方法主流是胃镜，但胃镜检查整个操作过程给受检者带来一定的痛苦甚至创伤，使人们对于胃镜检查存在一定的恐惧心理，为了达到无创检测，胶囊内镜逐渐应用于临床。但是由于胶囊内镜是被动移动，因而在胃中的检测部位很受局限，虽然很多专用于胃部的主动式胶囊内镜被提出，但大都处于研究阶段，而且是在胃内进行拍摄来诊断疾病，并没有专门对胃液进行分析来诊断胃部疾病的智能胶囊。At present, in clinical medicine, gastroscopy is the mainstream diagnostic method for gastric diseases, but the whole operation process of gastroscopy brings certain pain and even trauma to the subjects, which makes people have a certain fear of gastroscopy. In order to achieve non-invasive detection, Capsule endoscopy is gradually being used clinically. However, because the capsule endoscope is passively moved, the detection site in the stomach is very limited. Although many active capsule endoscopes dedicated to the stomach have been proposed, most of them are in the research stage, and the diagnosis is made by shooting in the stomach Diseases, and there is no smart capsule that analyzes gastric juice to diagnose gastric diseases.
在中国专利CN201210134190中提出了一种新型胃液隐血智能检测系统，该系统包括胃液隐血检测胶囊、体外便携式接收显示装置，胃液隐血检测胶囊主要包括胃液隐血检测模块、图像传感器、微处理器、信号无线发射模块等，胃液隐血检测模块检测胃液隐血情况并呈现颜色变化，图像传感器采集检测结果图像信息，经微处理器处理后由信号无线发射模块发射至体外便携式接收显示装置进行无线接收、存储及显示，并通过特定算法白动识别胃液隐血信息，医务工作人员或者患者根据体外便携式接收显示装置上的显示模块或报警模块判断胃内是否存在隐血。使用该隐血检测胶囊，受试者进行胃液隐血筛查时无创、无痛。但该胶囊系统检测项目单一，只能用于检测胃液中的隐血，且图像传感器与检测试纸之间有一定的距离用来聚焦，占据了胶囊内的很大空间。In Chinese patent CN201210134190, a novel gastric occult blood intelligent detection system is proposed. The system includes a gastric occult blood detection capsule and an in vitro portable receiving and display device. Transmitting module, etc. Gastric occult blood detection module detects gastric occult blood and presents color changes. The image sensor collects the image information of the detection results, and after processing by the microprocessor, the signal wireless transmitting module transmits to the external portable receiving and displaying device for wireless reception, storage and display. , and automatically identify gastric juice occult blood information through a specific algorithm, medical staff or patients judge whether there is occult blood in the stomach according to the display module or alarm module on the external portable receiving display device. Using the occult blood detection capsule, the test subjects performed non-invasive and painless gastric juice occult blood screening. However, the capsule system has a single detection item and can only be used to detect occult blood in gastric juice, and there is a certain distance between the image sensor and the detection test paper for focusing, which occupies a large space in the capsule.
发明内容Contents of the invention
本发明的目的是提供一种可部分脱离的智能胶囊，检测胃液当中的疾病标志物，胶囊检测完成后可脱离成两到三个部分，大大缩减了长度，便于排出体外，降低胶囊检测风险。The purpose of the present invention is to provide a partially detachable smart capsule to detect disease markers in gastric juice. After the capsule is detected, it can be detached into two to three parts, which greatly reduces the length, facilitates excretion, and reduces the risk of capsule detection.
本发明的技术方案：Technical scheme of the present invention:
可部分脱离的智能胶囊，包括主舱、反应舱、电池舱和两个固定环，其中，主舱内包含电源控制模块、无线发射模块、信号采集电路、两个挡板，反应舱内包括一个挡板、胃液检测传感器以及通孔，电池舱内包含微型电池和一个挡板。A partially detachable smart capsule, including a main cabin, a reaction cabin, a battery cabin and two fixing rings, wherein the main cabin contains a power control module, a wireless transmission module, a signal acquisition circuit, two baffles, and the reaction cabin includes a A baffle, a gastric juice detection sensor and a through hole, and the battery compartment contains a micro battery and a baffle.
所述两个固定环分别将主舱和电池舱，主舱和反应舱连接起来，在舱体接合处呈环状环绕于胶囊外壳外侧，宽度为2～5mm；选用的材料可降解或不可降解，有四种组合方式：电池舱一侧的固定环可降解，反应舱一侧的固定环可降解；电池舱一侧的固定环可降解，反应舱一侧的固定环不可降解；电池舱一侧的固定环不可降解，反应舱一侧的固定环可降解；电池舱一侧的固定环不可降解，反应舱一侧的固定环不可降解。The two fixing rings respectively connect the main cabin with the battery cabin, the main cabin and the reaction cabin, and surround the outside of the capsule shell in a ring shape at the junction of the cabins, with a width of 2-5 mm; the selected materials are degradable or non-degradable , there are four combinations: the fixing ring on the side of the battery compartment is degradable, the fixing ring on the side of the reaction compartment is degradable; the fixing ring on the side of the battery compartment is degradable, and the fixing ring on the side of the reaction compartment is not degradable; The fixing ring on the battery side is non-degradable, and the fixing ring on the side of the reaction chamber is degradable; the fixing ring on the battery side is non-degradable, and the fixing ring on the side of the reaction chamber is not degradable.
根据两个固定环所选材料的四种组合方式，所述电池舱和反应舱的脱落方式也有四种组合：电池舱可脱落，反应舱可脱落；电池舱可脱落，反应舱不可脱落；电池舱不可脱落，反应舱可脱落；电池舱不可脱落，反应舱不可脱落。According to the four combinations of materials selected by the two fixing rings, there are also four combinations for the detachment of the battery compartment and the reaction compartment: the battery compartment can be detached, and the reaction compartment can be detached; the battery compartment can be detached, and the reaction compartment cannot be detached; The compartment cannot fall off, but the reaction compartment can fall off; the battery compartment cannot fall off, and the reaction compartment cannot fall off.
所述两个固定环所选用的可降解材料选自以下物质中的一种：虫胶、聚乙烯醇乙酸苯二甲酸酯、丙烯酸树脂、邻苯二甲酸乙酸纤维素、邻苯二甲酸羟丙基甲基纤维素、聚乳酸。The degradable material selected for the two fixing rings is selected from one of the following substances: shellac, polyvinyl alcohol acetate phthalate, acrylic resin, cellulose acetate phthalate, phthalate hydroxy Propyl methylcellulose, polylactic acid.
所述反应舱所在端的两个挡板是透明的，电池舱所在端的两个挡板可以是透明的，也可以是不透明的。The two baffles at the end where the reaction chamber is located are transparent, and the two baffles at the end where the battery compartment is located may be transparent or opaque.
所述胃液检测传感器为检测试纸或检测电极或两者的组合；检测试纸选自以下的一种或几种：血红蛋白检测试纸、转铁蛋白检测试纸、幽门螺旋杆菌检测试纸以及癌胚抗原检测试纸；检测电极选自以下的一种或几种：pH检测电极、血红蛋白检测电极以及温度检测电极。The gastric juice detection sensor is a detection test paper or a detection electrode or a combination of both; the detection test paper is selected from one or more of the following: hemoglobin detection test paper, transferrin detection test paper, Helicobacter pylori detection test paper and carcinoembryonic antigen detection test paper ; The detection electrode is selected from one or more of the following: pH detection electrode, hemoglobin detection electrode and temperature detection electrode.
所述信号采集电路所采集的信号为以下信号形式的一种或几种：图像信号、数字编码信号、光信号、电流信号、电压信号、压力信号、电磁信号。The signal collected by the signal collection circuit is one or more of the following signal forms: image signal, digital code signal, light signal, current signal, voltage signal, pressure signal, electromagnetic signal.
所述微型电池采用三块纽扣电池。Described microbattery adopts three button batteries.
所述微型电池与电源控制模块之间的通过导线或触点连接。The micro-battery is connected with the power control module through wires or contacts.
所述胃液检测传感器与信号采集电路之间采用有线或无线连接，其中有线连接为导线连接或触点连接；无线连接时，信号采集电路所采集的信号为光信号或图像信息或电磁信息。The gastric juice detection sensor is connected to the signal acquisition circuit by wired or wireless connection, wherein the wired connection is a wire connection or a contact connection; in the wireless connection, the signal collected by the signal acquisition circuit is optical signal or image information or electromagnetic information.
所述导线连接，导线材料为铝，可以被胃酸分解，长度为5～20mm，直径为0.5～1.5mm，导线穿过两个挡板，并且在两个挡板被导线穿透处的表面涂抹防水胶，防止胃液进入舱体。The wire is connected, the wire material is aluminum, which can be decomposed by gastric acid, the length is 5-20 mm, the diameter is 0.5-1.5 mm, the wire passes through the two baffles, and the surface of the two baffles where the wire penetrates Waterproof glue to prevent gastric juice from entering the cabin.
所述触点穿过两个挡板，并且在两个挡板被触点穿透处的表面涂抹防水胶，防止胃液进入舱体。The contacts pass through the two baffles, and waterproof glue is applied on the surfaces of the two baffles where the contacts penetrate to prevent gastric juice from entering the cabin.
所述触点包括上拉杆、上端触盘、下端触盘、下拉杆、针孔和触针；上端触盘的厚度为0.5～2mm，与下端触盘的接触面积为2～12mm2，形状为圆形或椭圆形或矩形或菱形或梯形；下端触盘的厚度和形状与上端触盘相同；针孔是圆柱孔，直径为1～2mm，高度小于上端触盘的厚度，个数为1～3个；所述触针是圆柱体，直径略小于针孔，高度与针孔相同或略高于针孔，个数及位置分布与针孔相同。The contact includes an upper rod, an upper contact disc, a lower contact disc, a lower rod, a pinhole and a contact pin; the thickness of the upper contact disc is 0.5-2 mm, and the contact area with the lower contact disc is 2-12 mm2 , and the shape is Circular or oval or rectangular or rhombus or trapezoidal; the thickness and shape of the lower contact plate are the same as that of the upper contact plate; the pinhole is a cylindrical hole with a diameter of 1 to 2mm and a height smaller than the thickness of the upper contact plate, and the number is 1～ 3; the contact pins are cylinders, the diameter is slightly smaller than the pinhole, the height is the same as the pinhole or slightly higher than the pinhole, and the number and position distribution are the same as the pinhole.
胶囊内的四个挡板直径与胶囊内壁相同，挡板的外圆周用胶水固定在胶囊内壁上，不能移动。The four baffles in the capsule have the same diameter as the inner wall of the capsule, and the outer circumferences of the baffles are fixed on the inner wall of the capsule with glue and cannot be moved.
本发明的工作过程：Working process of the present invention:
所述可部分脱离的智能胶囊经口服进入胃内，胃液通过通孔进入反应舱，胃液检测传感器与胃液接触，检测胃部疾病标志物的信息，信号采集电路采集并处理胃液检测传感器检测到的信息，无线发射模块将检测信息发送到体外；智能胶囊检测完成之后，胶囊根据两个固定环所采用的材料而脱离成两个或三个独立舱体，或者不进行脱离，然后经由胃肠道的蠕动，排出体外。The partially detachable smart capsule enters the stomach through oral administration, and the gastric juice enters the reaction chamber through the through hole. The gastric juice detection sensor contacts the gastric juice to detect the information of gastric disease markers, and the signal acquisition circuit collects and processes the information detected by the gastric juice detection sensor. information, the wireless transmission module sends the detection information to the outside of the body; after the smart capsule detection is completed, the capsule is detached into two or three independent compartments according to the materials used in the two fixing rings, or does not detach, and then passes through the gastrointestinal tract Peristalsis, excreted from the body.
本发明所提供的可部分脱离的智能胶囊，可将一整个的胶囊分解成两个或三个小舱体，有效降低胶囊进入人体无法排出的风险；不采用传统的胶囊拍摄胃肠壁图片的方式，而是采用免疫化学传感器获取疾病信息，且检测多个标志物，增加检测结果的可靠性。The partially detachable smart capsule provided by the present invention can decompose a whole capsule into two or three small cabins, effectively reducing the risk of the capsule entering the human body and being unable to discharge; it does not use traditional capsules to take pictures of the gastrointestinal wall Instead, immunochemical sensors are used to obtain disease information and detect multiple markers to increase the reliability of the test results.
附图说明：Description of drawings:
图1为可部分脱离的智能胶囊整体架构示意图；Figure 1 is a schematic diagram of the overall structure of a partially detachable smart capsule;
图2为可部分脱离的智能胶囊结构示意图；Fig. 2 is a schematic structural diagram of a partially detachable smart capsule;
图3为可部分脱离的智能胶囊主舱与电池舱的导线连接示意图；Fig. 3 is a schematic diagram of wire connections between the main compartment of the partially detachable smart capsule and the battery compartment;
图4为可部分脱离的智能胶囊主舱与电池舱的触点连接示意图；Fig. 4 is a schematic diagram of the contact connection between the main compartment of the partially detachable smart capsule and the battery compartment;
图5为可部分脱离的智能胶囊主舱与反应舱的导线连接示意图；Fig. 5 is a schematic diagram of wire connections between the main compartment of the partially detachable smart capsule and the reaction compartment;
图6为可部分脱离的智能胶囊主舱与反应舱的触点连接示意图；Fig. 6 is a schematic diagram of the contact connection between the main compartment of the partially detachable smart capsule and the reaction compartment;
图7为触点连接的具体结构示意图；Fig. 7 is a specific structural schematic diagram of contact connection;
图8为本发明实施例可部分脱离的智能胶囊结构示意图；Fig. 8 is a schematic structural diagram of a partially detachable smart capsule according to an embodiment of the present invention;
图9为本发明实施例可部分脱离的智能胶囊部分脱离之后的效果图；Fig. 9 is an effect diagram after partial detachment of the partially detachable smart capsule according to the embodiment of the present invention;
图10为本发明实施例胃液中疾病标志物检测的阳性结果示意图。Fig. 10 is a schematic diagram of positive results of detection of disease markers in gastric juice according to an embodiment of the present invention.
在图1至图10中：In Figures 1 to 10:
1━主舱、2━反应舱、3━电池舱、4━固定环、4a━固定环、5━微型电池、6━电源控制模块、7━无线发射模块、8━信号采集电路、9━胃液检测传感器、10━挡板、10a━挡板、10b━挡板、10c━挡板、11━通孔、12━血红蛋白检测试纸、13━癌胚抗原检测试纸、14━LED灯组、15━CMOS传感器、16━微控制器、17━导线、18━触点、17a━导线、18a━触点、19━上拉杆、20━上端触盘、21━下端触盘、22━针孔、23━触针、24━下拉杆。1━Main compartment, 2━Reaction compartment, 3━Battery compartment, 4━Fixed ring, 4a━Fixed ring, 5━Micro battery, 6━Power control module, 7━Wireless transmitter module, 8━Signal acquisition circuit, 9━ Gastric fluid detection sensor, 10━baffle, 10a━baffle, 10b━baffle, 10c━baffle, 11━through hole, 12━hemoglobin detection test paper, 13━carcinoembryonic antigen detection test paper, 14━LED lamp group, 15 ━CMOS sensor, 16━microcontroller, 17━wire, 18━contact, 17a━wire, 18a━contact, 19━upper rod, 20━upper contact plate, 21━lower contact plate, 22━pinhole, 23━stylus, 24━pull down bar.
具体实施方式detailed description
如图8所示，一种可部分脱离的智能胶囊，包括主舱1、反应舱2、电池舱3、固定环4和固定环4a，其中，主舱1内包含电源控制模块6、无线发射模块7、微控制器16、CMOS传感器15、LED灯组14、挡板10a和挡板10b，反应舱2内包括挡板10c、血红蛋白检测试纸12、癌胚抗原检测试纸13以及通孔11，电池舱3内包含微型电池5和挡板10。As shown in Figure 8, a partially detachable smart capsule includes a main compartment 1, a reaction compartment 2, a battery compartment 3, a fixing ring 4 and a fixing ring 4a, wherein the main compartment 1 contains a power control module 6, a wireless transmitter Module 7, microcontroller 16, CMOS sensor 15, LED lamp group 14, baffle 10a and baffle 10b, reaction chamber 2 includes baffle 10c, hemoglobin detection test paper 12, carcinoembryonic antigen detection test paper 13 and through hole 11, The battery compartment 3 contains a micro battery 5 and a baffle 10 .
固定环4将主舱1和电池舱3连接，固定环4a将主舱1和反应舱2连接，固定环4和4a在舱体接合处绕胶囊外壳外侧涂抹成环状，宽度为2～5mm。固定环4和4a都选用可降解材料，具体为聚乙烯醇乙酸苯二甲酸酯。The fixing ring 4 connects the main cabin 1 and the battery cabin 3, and the fixing ring 4a connects the main cabin 1 and the reaction cabin 2. The fixing rings 4 and 4a are formed into rings around the outside of the capsule shell at the junction of the cabins, with a width of 2-5 mm. . Both the fixing rings 4 and 4a are made of degradable materials, specifically polyvinyl acetate phthalate.
挡板4、4a、4b、4c均选用透明材料，直径与胶囊内壁相同，外圆周用胶水固定在胶囊内壁上，不能移动。The baffles 4, 4a, 4b, 4c are all made of transparent material, the diameter is the same as the inner wall of the capsule, and the outer circumference is fixed on the inner wall of the capsule with glue and cannot be moved.
微型电池5与电源控制模块6之间采用触点18连接，触点18穿过挡板10和10a，两个挡板被触点18穿透处的表面涂有防水胶。The contact 18 is used to connect the micro-battery 5 and the power control module 6, and the contact 18 passes through the baffles 10 and 10a, and the surfaces of the two baffles penetrated by the contacts 18 are coated with waterproof glue.
如图7所示，触点18包括上拉杆19、上端触盘20、下端触盘21、下拉杆24、针孔22和触针23；上端触盘的厚度为1.2mm，与下端触盘的接触面积为6mm2，形状为圆形；下端触盘的厚度和形状与上端触盘相同；针孔是圆柱孔，直径为1.2mm，高度为0.9mm，个数为2个；触针23是圆柱体，直径为1.1mm，高度1.2mm，个数及位置分布与针孔22相同。As shown in Figure 7, the contact 18 includes an upper pull rod 19, an upper contact disc 20, a lower contact disc 21, a lower rod 24, a pinhole 22 and a contact pin 23; The contact area is 6mm2 , and the shape is circular; the thickness and shape of the lower contact plate are the same as the upper contact plate; the pinhole is a cylindrical hole with a diameter of 1.2mm and a height of 0.9mm, and the number is 2; the contact pin 23 is The cylinder has a diameter of 1.1 mm and a height of 1.2 mm, and the number and position distribution are the same as those of the pinholes 22 .
通孔11设为椭圆形开孔，便于胃液流入胶囊，其长轴为2～5mm，短轴为1～2.5mm，个数为对称的两个；微控制器16采用现有技术中常用的控制电路；微型电池5采用三块纽扣电池；电源控制模块6采用磁控方式，LED灯组14的小灯个数为2～4个，采用贴片式发光二极管，颜色采用白光，且为散光照射；血红蛋白检测试纸12、癌胚抗原检测试纸13的检测端粘贴在两个通孔11处，另一端粘贴在反应舱2的内壁上。The through hole 11 is set as an elliptical opening, which is convenient for gastric juice to flow into the capsule. Its long axis is 2-5mm, its short axis is 1-2.5mm, and the number is two symmetrical; Control circuit; the micro battery 5 adopts three button batteries; the power control module 6 adopts a magnetic control method, and the number of small lights of the LED lamp group 14 is 2 to 4, and the color is white light, and it is astigmatism Irradiation; the detection ends of the hemoglobin detection test paper 12 and the carcinoembryonic antigen detection test paper 13 are pasted at the two through holes 11 , and the other ends are pasted on the inner wall of the reaction chamber 2 .
如图10所示，为本实施例的智能胶囊胃液中疾病标志物检测的阳性结果示意图，血红蛋白检测试纸12与癌胚抗原检测试纸13均采用胶体金免疫层析法制作，特异性针对人血红蛋白和癌胚抗原，且检测灵敏度高，若胃液中存在血红蛋白，则血红蛋白检测试纸12显示两条红线，若不存在，则显示一条红线；同理，若胃液中存有癌胚抗原，则癌胚抗原检测试纸13显示两条红线，若不存在，则显示一条红线。As shown in Figure 10, it is a schematic diagram of the positive results of the detection of disease markers in the smart capsule gastric juice of this embodiment. The hemoglobin detection test paper 12 and the carcinoembryonic antigen detection test paper 13 are both produced by colloidal gold immunochromatography, which are specific for human hemoglobin and carcinoembryonic antigen, and the detection sensitivity is high. If there is hemoglobin in the gastric juice, the hemoglobin test paper 12 will show two red lines, and if it does not exist, it will show a red line; similarly, if there is carcinoembryonic antigen in the gastric juice, the carcinoembryonic Antigen detection test paper 13 shows two red lines, if not present, then shows a red line.
本实施例的工作过程如下：受检者服入可部分脱离的智能胶囊，胶囊进入胃部且开始工作，胃液通过通孔11进入反应舱2，反应舱2中的血红蛋白检测试纸12和癌胚抗原检测试纸13与胃液接触，胃液沿着试纸向上层析并发生显色反应，CMOS传感器15采集到两个试纸的颜色变化，再经由微控制器16进行一定的处理，最由无线发射模块7传送到体外。体内的智能胶囊检测完成，进入小肠后，两个可降解的固定环4和4a逐渐降解，最终脱离成三个独立舱体，大大缩短了整个胶囊的长度，如图9所示，为本发明实施例可部分脱离的智能胶囊部分脱离之后的效果图。检测结果中如果血红蛋白检测试纸12出现两条红线，则说明胃部有出血；如果癌胚抗原检测试纸13出现两条红线，则说明胃液中含有一定量的癌胚抗原。The working process of this embodiment is as follows: the subject takes a partly detachable smart capsule, the capsule enters the stomach and starts to work, the gastric juice enters the reaction chamber 2 through the through hole 11, the hemoglobin detection test paper 12 and the carcinoembryon in the reaction chamber 2 The antigen detection test paper 13 is in contact with the gastric juice, and the gastric juice is chromatographically along the test paper and undergoes a color reaction. The CMOS sensor 15 collects the color changes of the two test papers, and then performs certain processing through the microcontroller 16. Finally, the wireless transmission module 7 sent outside the body. After the detection of the smart capsule in the body is completed, after entering the small intestine, the two degradable fixing rings 4 and 4a gradually degrade, and finally detach into three independent cabins, which greatly shortens the length of the entire capsule, as shown in Figure 9, which is an example of the present invention. The rendering of the partial detachable smart capsule of the embodiment after partial detachment. In the test result, if two red lines appear on the hemoglobin test paper 12, it means that there is bleeding in the stomach; if two red lines appear on the carcinoembryonic antigen test paper 13, it means that a certain amount of carcinoembryonic antigen is contained in the gastric juice.
本发明不局限于上述具体实施方式，根据上述内容，按照本领域的普通技术知识和惯用手段，在不脱离本发明上述基本技术思想前提下，本发明还可以做出其他多种形式的等效修改、替换或变更，均落在本发明的保护范围之中。The present invention is not limited to the above-mentioned specific implementation methods. According to the above-mentioned content, according to the common technical knowledge and conventional means in this field, without departing from the above-mentioned basic technical idea of the present invention, the present invention can also make other equivalents in various forms. Amendments, substitutions or alterations all fall within the protection scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610854129.8ACN106344044A (en) | 2016-09-27 | 2016-09-27 | Partially separable smart capsule |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610854129.8ACN106344044A (en) | 2016-09-27 | 2016-09-27 | Partially separable smart capsule |
| Publication Number | Publication Date |
|---|---|
| CN106344044Atrue CN106344044A (en) | 2017-01-25 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610854129.8APendingCN106344044A (en) | 2016-09-27 | 2016-09-27 | Partially separable smart capsule |
| Country | Link |
|---|---|
| CN (1) | CN106344044A (en) |
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| CN110464289A (en)* | 2019-07-12 | 2019-11-19 | 重庆金山医疗器械有限公司 | A kind of patency capsule and patency capsule detection system |
| US20240108241A1 (en)* | 2020-05-12 | 2024-04-04 | Massachusetts Institute Of Technology | Gastroretentive articles for alcohol sensing |
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| WO2005062717A2 (en)* | 2003-12-31 | 2005-07-14 | Given Imaging Ltd. | In-vivo sensing device with detachable part |
| CN102631183A (en)* | 2012-05-03 | 2012-08-15 | 重庆大学 | Novel intellectual detection system of gastric fluid occult blood |
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005062717A2 (en)* | 2003-12-31 | 2005-07-14 | Given Imaging Ltd. | In-vivo sensing device with detachable part |
| CN102631183A (en)* | 2012-05-03 | 2012-08-15 | 重庆大学 | Novel intellectual detection system of gastric fluid occult blood |
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| CN110464289A (en)* | 2019-07-12 | 2019-11-19 | 重庆金山医疗器械有限公司 | A kind of patency capsule and patency capsule detection system |
| US20240108241A1 (en)* | 2020-05-12 | 2024-04-04 | Massachusetts Institute Of Technology | Gastroretentive articles for alcohol sensing |
| US12138034B2 (en)* | 2020-05-12 | 2024-11-12 | Massachusetts Institute Of Technology | Gastroretentive articles for alcohol sensing |
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