Content of the invention
Technical problem solved by the invention is to provide a kind of dried orange peel wine of regulating qi-flowing for eliminating phlegm, and it is with dried orange peel, Poria cocos, wild jujubeBenevolence, Radix Glycyrrhizae, sea-buckthorn are bulk drug, allocate preparation with wine.The modulation local flavor such as xylitol can also be added on this basis, dashed forwardGo out the peculiar fragrance of dried orange peel, there is regulating qi-flowing for eliminating phlegm effect, the plentiful dried orange peel wine of mouthfeel.
Regulating qi-flowing for eliminating phlegm dried orange peel wine of the present invention, including the following raw material medicine and white wine:
Bulk drug, by weight ratio count: 0.5～5 part of dried orange peel, 0.1～0.53 part of Poria cocos, 0.19～0.67 part of spina date seed,0.03～0.13 part of Radix Glycyrrhizae, 0.07～0.33 part of sea-buckthorn；
Appropriate white wine.
Further preferably, regulating qi-flowing for eliminating phlegm dried orange peel wine of the present invention, the bulk drug including following weight proportion and white wine:
Bulk drug, 0.5～5 part of dried orange peel, 0.1～0.53 part of Poria cocos, 0.19～0.67 part of spina date seed, Radix Glycyrrhizae 0.03～0.13Part, 0.07～0.33 part of sea-buckthorn；
93.24～99.11 parts of white wine.
Still more preferably, regulating qi-flowing for eliminating phlegm dried orange peel wine of the present invention, also includes flavor enhancement, and described flavor enhancement is rock sugar, wood sugarAt least one of alcohol, lemon, peppermint, preferably xylitol.
Most preferably, regulating qi-flowing for eliminating phlegm dried orange peel wine of the present invention, including the bulk drug of following weight proportion, flavor enhancement and white wine:
Bulk drug, 0.5～5 part of dried orange peel, 0.1～0.53 part of Poria cocos, 0.19～0.67 part of spina date seed, Radix Glycyrrhizae 0.03～0.13Part, 0.07～0.33 part of sea-buckthorn；
Flavor enhancement: 0.01～0.1 part of xylitol；
93.24～99.11 parts of white wine.
The white wine that the present invention adopts is aromatic Chinese spirit.The alcoholic strength of gained regulating qi-flowing for eliminating phlegm dried orange peel wine is 18～45%vol.
The preparation method of regulating qi-flowing for eliminating phlegm dried orange peel wine of the present invention, without flavor enhancement it is characterised in that: comprise the steps:
(1) weigh bulk drug；Count by weight ratio: 0.5～5 part of dried orange peel, 0.1～0.53 part of Poria cocos, spina date seed 0.19～0.67 part, 0.03～0.13 part of Radix Glycyrrhizae, 0.07～0.33 part of sea-buckthorn；
(2) bulk drug Poria cocos, spiny jujuba seed powder are broken to and at least cross 20 mesh sieves；
(3) bulk drug Poria cocos, spina date seed, Radix Glycyrrhizae, sea-buckthorn, plus 5～12 times amount 30～45%vol soaking in Chinese liquor, during immersionBetween be 15～30 days, temperature be 20～30 DEG C；Filter to obtain compound raw material extraction stoste；
(4) take dried orange peel, at 50～140 DEG C, baking time is 30min～6h to baked temperature；
(5) take the described baking dried orange peel of step (4), with 5～40 times amount water extraction modes in addition Soxhlet thermal circulation method to dried orange peelActive material and flavor substance are extracted, and extraction time is 1～4h, obtains dried orange peel aqueous extract；
(6) dried orange peel after step (5) water extraction is extracted with 5～20 times amount 20～60%vol soaking in Chinese liquor, soak time is7～25 days, soaking temperature was 20～30 DEG C；Filter, concentrate, obtain dried orange peel alcohol extract；
(7) step (3) gained compound raw material extraction stoste, step (5) gained dried orange peel aqueous extract, step (6) gained is oldSkin alcohol extract, plus white wine adjustment alcoholic strength is to setting.
The preparation method of regulating qi-flowing for eliminating phlegm dried orange peel wine of the present invention, containing flavor enhancement it is characterised in that: comprise the steps:
(1) weigh bulk drug；Count by weight ratio: 0.5～5 part of dried orange peel, 0.1～0.53 part of Poria cocos, spina date seed 0.19～0.67 part, 0.03～0.13 part of Radix Glycyrrhizae, 0.07～0.33 part of sea-buckthorn；
Weigh flavor enhancement: 0.01～0.1 part；
(2) bulk drug Poria cocos, spiny jujuba seed powder are broken to and at least cross 20 mesh sieves；
(3) bulk drug Poria cocos, spina date seed, Radix Glycyrrhizae, sea-buckthorn, plus 5～12 times amount 30～45%vol soaking in Chinese liquor, during immersionBetween be 15～30 days, temperature be 20～30 DEG C；Filter to obtain compound raw material extraction stoste；
(4) dried orange peel is taken to bake, at 50～140 DEG C, baking time is 30min～6h to baked temperature；
(5) take the described baking dried orange peel of step (4), with 5～40 times amount water extraction modes in addition Soxhlet thermal circulation method to dried orange peelActive material and flavor substance are extracted, and extraction time is 1～4h, obtains dried orange peel aqueous extract；
(6) dried orange peel after step (5) water extraction is extracted with 5～20 times amount 20～60%vol soaking in Chinese liquor, soak time is7～25 days, soaking temperature was 20～30 DEG C；Filter, concentrate, obtain dried orange peel alcohol extract；
(7) step (3) gained compound raw material extraction stoste, step (5) gained dried orange peel aqueous extract, step (6) gained is oldSkin alcohol extract, flavor enhancement, plus white wine adjustment alcoholic strength is to setting.
Wherein, described flavor enhancement is at least one of rock sugar, xylitol, lemon, sweet osmanthus, peppermint；Preferably xylitol；Enter oneWalk 0.01～0.1 part of preferred xylitol.
Further, the aqueous solution of at least one of described flavor enhancement rock sugar, xylitol, lemon, sweet osmanthus, peppermint；ExcellentSelect wood sugar alcohol solution；Described wood sugar alcohol solution: take xylitol, be dissolved in water, filter, obtain wood sugar alcohol solution；Preferably,Amount of water is at least 0.5 times amount；It is furthermore preferred that amount of water is 1 times amount.
Dried orange peel wine of the present invention weighs bulk drug, flavor enhancement and white wine by aforementioned weight proportioning, and preparation method includes walking as followsRapid:
(1) in order to be in harmonious proportion dried orange peel entirety local flavor, dried orange peel is carried out or is not baked, baked temperature at 50～140 DEG C, dryThe roasting time is 30min～6h.
(2) Poria cocos, spina date seed are crushed, cross 20 mesh sieves.
(3) claim dried orange peel, with 5～40 times amount water extraction modes in addition Soxhlet thermal circulation method to dried orange peel active material and local flavorMaterial is extracted, and extraction time is 1～4h, obtains dried orange peel aqueous extract.
(4) the dried orange peel raw material after water extraction is extracted with 5～20 times amount 20～60%vol white wine, extraction time be 7～25 days, Extracting temperature was 20～30 DEG C, extract was carried out filter, distillation and concentration is processed, and obtains dried orange peel alcohol extract.
(5) weigh the Poria cocos after crushing, spina date seed, Radix Glycyrrhizae, sea-buckthorn, add 5～12 times amount 30～45%vol white wine to carry outSoak extraction, soak time is 15～30 days, and temperature is 20～30 DEG C.
(6) leaching liquor is removed the dregs of a decoction, become Poria cocos extraction stoste after filtration treatment.
(7) take xylitol, be dissolved in water, filter, obtain wood sugar alcohol solution；Preferably, amount of water is at least 0.5 times amount；It is furthermore preferred that amount of water is 1 times amount；Or omit this step.
(8) dried orange peel Aqueous extracts, dried orange peel alcohol extract, Poria cocos extraction stoste, wood sugar alcohol solution are proportionally added into white wineIn, adjustment alcoholic strength is 18～45%vol, and is settled to 1000l, filters, filling, obtains the reason of alcoholic strength 18～45%volGasification phlegm dried orange peel wine.
The reason present invention adopts each bulk drug is as follows:
Dried orange peel is dried pericarp for the variety of rutaceae orange, records according to the 5th edition Chinese Pharmacopoeia in 2010,Dried orange peel is divided into dried orange peel and citrus chachiensis hortorum.Dried orange peel mainly contains volatile oil, flavonoids, alkaloid, inositol, vitamin b1 etc..Volatile oilContent is of a relatively high, and about 2%～4%, mainly include limonene, γ-terpinene, beta-myrcene, australene, nopineneDeng, linalool, citral and α-terpineol etc. (containing limonene, 7- terpinene, foretelling the composition such as laurene and alpha-terpineol)；YellowThe basic parent nucleus of ketone compounds is 2- phenyl chromone, wherein with aurantiamarin (3.5%), neohesperidin, Nobiletin, shaddockSkin glycosides, narirutin and 3,5,6,7,8,3 ', 4 '-Heptamethoxyflavone is main component, also contain 5,6,7,3 ', 4 '-Pentamethoxyl flavones, 1,5,6,7,3 ', 4 '-hexa methoxy flavones, 1,5,7,8,3 ', many methoxies such as 4 '-hexa methoxy flavonesBase flavone compound；Alkaloid is then with synephrine as representative；Additionally, dried orange peel also contains k, the various trace elements such as na, ca.Dried orange peel is warm in nature, bitter, pungent, return lung, the spleen channel, there is regulating qi-flowing for strengthening spleen, hot-tempered humidifying phlegm.Dried orange peel is loaded in for the orange peel head that is used as medicineShennong's Herbal, the name of dried orange peel begins to see " dietetic materia medica ".It is bitter, pungent, warm that Chinese Pharmacopoeia records dried orange peel nature and flavor.Enter spleen, lung channel, haveWhet the appetite in regulating qi-flowing for strengthening spleen, stopping nausea and vomiting by lowering the adverse flow of QI, tune.Eliminating dampness and eliminating phlegm the effects such as.Shennong's Herbal remembers orange peel, that is, present oldSkin, has functions that qi-regulating." Mingyi Bielu " increases effect of its antidiarrheal, diuresis on the basis of qi-regulating.Until later, " thisGrass is picked up any lost article from the road ", just describe the effect of the dried orange peel being presently believed that the most prominent " resolving sputum " in numerous works such as " new compilation of materia medica ".
Radix Glycyrrhizae includes containing chemical composition: glucityl liquiritin, different glycyrrhiza glabra glucoside, summer stroke support glucoside, glycyrrhizin -4'- celery sugarGlucoside, liquiritin, 6'- acetyl liquiritin, isoviolanthin, isoliquiritigenin glucose apiin, liquiritoside a, liquiritoside b,Glycyrrhizin, 3-0- [beta -d-glucose- aldehydic acid methyl esters-(1 → 2)-beta -d-glucose- aldehydic acid] -24- hydroxyl-licorice root lactone, Radix Glycyrrhizae soapGlucoside e2, isoliquiritigenin, glycyrol, glycyrrhizic acid, glycycoumarin, licoisoflavanone, licoisoflavanone first, Glycyrrhiza UralensisSaponin second, neoglycyrol and glycyrrhizic acid b2.Radix Glycyrrhizae nature and flavor are sweet flat, and the thoughts of returning home, lung, spleen, stomach, have tonifying spleen and stomach, beneficial gas are multipleThe effect of arteries and veins.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitaition move, intermittent pulse.And Radix Glycyrrhizae is invigorated the spleen and benefited qi, clearing heat and detoxicating, expelling phlegm and arresting coughing,Relieving spasm to stop pain, coordinating the drug actions of a prescription.For taste void meat, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction,Carbuncle sore tumefacting virus, alleviate poisonous substance toxicity, strong.Modern medicine shows that Radix Glycyrrhizae has anti-inflammatory, the multiple efficacies such as antiviral, antitumor.Wherein enoxolone can be with anti-inflammatory, antibacterial, anti-arrhythmia；Licoflavone can antitumor, anti-arrhythmia, antiulcer etc.；Licorice polysaccharide participate in immunological regulation, can be antiviral, antitumor.
Poria cocos contains pachymose, pachymic acid, protein, fat, lecithin, histidine, choline, ergosterol and sylvite etc..There is the effects such as Li Shui, resolving sputum.With dried orange peel compatibility resolving sputum.
Spina date seed fat oil containing volume and protein, sterol, betulin, betulic acid, jujuboside, jujubogenin,Vitamin c.Nourishing the liver, calming heart, calm the nerves, arrest sweating.Control restlessness of asrhenia type and insomnia, palpitation of palpitating with fear, polydipsia, abnormal sweating.Then calm the nerves with Poria cocos compatibility.
Sea-buckthorn can be used as medicine, being capable of relieving cough and reducing sputum, stomach strengthening and digestion promoting, promoting blood circulation to remove blood stasis etc..Sea-buckthorn contains protein, fat, slightly fibreDimension, carbohydrate, carrotene, vitamin b1, vitamin b2, vitamin c, nicotinic acid etc..Additionally, also containing Isorhamnetin, AsiaOleic acid, leukotrienes, folic acid, malic acid, stearic acid, oleic acid, zeaxanthine, palmitic acid etc..There is higher nutrition and useIt is worth.
Xylitol is a kind of natural sweet taste extracting from the plant materials such as silver birch, Oak Tree, corncob, bagasseAgent.Xylitol provides energy for human body, synthesizes glycogen, reduces the consumption of the protein in fat and hepatic tissue, so that liver is subject toProtection and reparation, reduce the generation of harmful ketoboidies in human body, will not be, because edible, worry of getting fat.Can be widely used for food, doctorThe fields such as medicine, light industry.Xylitol, compared with common white granulated sugar, has heat every gram of xylitol of low advantage and contains only2.4 caloric heats, the heat few 40% of carbohydrate more most of than other, thus xylitol can be applied to various fat-reducingIn food, as the substitute of high heat white sugar.
The present invention, with natural products as raw material, has played medicine-food two-purpose medicinal material dried orange peel, Poria cocos, Radix Glycyrrhizae, spina date seed, sea-buckthorn etc.Respective advantage it is ensured that health be worth while, highlight the fragrance of dried orange peel, accomplished that wine body is plentiful, aroma Chen Ya, mouthfeel fromSo, without food additives, no side effectses, and there is the effect of regulating qi-flowing for eliminating phlegm health care.It is an advantage of the current invention thatProduction technology science is simple, and product has health value and cultureal value concurrently, has larger market development potential.
Specific embodiment
The following is formula and the preparation method screening test of regulating qi-flowing for eliminating phlegm dried orange peel wine of the present invention.
First, regulating qi-flowing for eliminating phlegm dried orange peel wine formula is selected
Process of the test of the present invention designs dried orange peel wine compound four according to regulating qi-flowing for eliminating phlegm traditional Chinese medical science logos altogether, specifically as shown in table 1.Finally we determine inventive formulation at screening process as follows.Concretely comprise the following steps: (1) is claimed respectively by compound designTake dried orange peel, Buddha's hand, Radix Glycyrrhizae, radish seed, sea-buckthorn, spina date seed, dried orange peel obtains high concentration extract extract, Buddhist with Soxhlet water extractionHand, Radix Glycyrrhizae, radish seed, sea-buckthorn, spina date seed extract to obtain respective extract with 10 times amount 35%vol white wine respectively.(2) by professional wineAbove 5 extracts are carried out mixing preparation according to different ratio and must test sample wine by body designer.(3) people please be tasted and appraised by wine bodyMember does sensory evaluation to gained test sample wine, and selects the group that sense organ compounds optimum, to determine inventive formulation.
Table 1 compound designs
| Compound is numbered | Compound |
| 1 | Dried orange peel, Buddha's hand |
| 2 | Dried orange peel, Radix Glycyrrhizae, radish seed |
| 3 | Dried orange peel, Poria cocos, Radix Glycyrrhizae, sea-buckthorn |
| 4 | Dried orange peel, Poria cocos, Radix Glycyrrhizae, sea-buckthorn, spina date seed |
By sensory test draw formula of the present invention go with wine body can show dried orange peel fragrance project, typical case, aromaFragrant coordination, the basic characteristics such as wine body rich in taste with medicine, this feature is coincide with target, so selecting inventive formulation.
2nd, preparation method screening
1st, dried orange peel extract extracting method is selected
Fragrant to dried orange peel using methods such as heating water extraction, distillation extraction, normal temperature alcohol extracting, Soxhlet water extractions respectively in process of the present inventionGas composition is extracted and is compared, and is determined the Soxhlet water extraction of dried orange peel in the present invention.If method particularly includes: weigh dried orange peelDry, it is divided into 4 parts, with method in above 4, dried orange peel is extracted with identical solid-liquid ratio, and with gc-ms com-parison and analysis instituteObtain fragrance component Species differences in extract, do subjective appreciation.4 kinds of extracting methods are shown in figure to the impact of dried orange peel extract fragrance component1, sense organ measurement result is shown in as table 2 below.
Table 2 Different Extraction Method gained dried orange peel extract sense organ
| Extracting method | Color and luster | Fragrance, mouthfeel |
| Heating water extraction | Rufous | There is Chen Xiang and project, and have fruital；Numb, puckery, bitter |
| Distillation is extracted | White | Dried orange peel is fragrant, strong；Slight bitter, micro- fiber crops |
| Normal temperature alcohol extracting | Rufous | Dried orange peel is aromatic strongly fragrant, has Chen Muxiang and fruital；Fiber crops are puckery heavy, bitter |
| Soxhlet water extraction | Rufous | Dried orange peel perfume (or spice) is pure, typical case, and Chen Muxiang projects；Slight bitter, micro- fiber crops |
All be can be seen that by Fig. 1 and Biao 2, with fragrance component quantity in Soxhlet water extraction gained dried orange peel extract relativelyFew, but typical case and pure.And the bitter taste of method gained dried orange peel extract of Soxhlet water extraction, spicy, pungent taste are intended to than otherMethod gained extract is light.So the present invention selects the method that Soxhlet water extraction is extracted as dried orange peel Aqueous extracts.
The class material being represented with aurantiamarin for physiology active ingredient in dried orange peel is dissolved in alcohol, but less or water insoluble, soOn the basis of Soxhlet water extraction, dried orange peel is done with further alcohol extracting in the present invention, to obtain more beneficiating ingredients.
2nd, in dried orange peel Soxhlet water extraction method extracting parameter determination
After determining Soxhlet extraction method, we select to withdrawal ratio and extraction time.In experiment with 5 times amount it isGradient, sets the feed liquid multiples such as 5,10,15,20,25,30,35,40 respectively, and sets extraction time in 1～4h development extraction test,Finally organoleptic detection is carried out to the other extract of different group, modulated by sample wine, finally determine that setup parameter of the present invention is all permissibleRealize the preparation of described dried orange peel wine.
3rd, the white wine number of degrees are on total starches content impact in compound raw material extraction stoste
In compound extract extraction process, set 25%vol, 30%vol, 35%vol, 40%vol, 45%vol etc. 5Individual gradient does parallel test, respectively total starches in gained extract is measured, result is shown in Fig. 2.
As shown in Figure 2, in compound stoste total starches content be in maintenance level between 30%vol～45%vol it is considered toTo the stability (the wine degree difference between extract and product is relatively small) of final products wine, so setting the present invention to extract wine degreeIn 30%vol～45%vol.
4th, extraction number of days is on the extraction stoste color and luster impact of compound raw material
In order to determine compound raw material extraction number of days, during invention, setting 5 times of 10,15,20,25,30 grade are carriedTake, and detect gained extract all-wave length absorbance (200nm-800nm), finally select the extinction that 350nm measures gained stosteDegree, result is as shown in Figure 3.Can be seen that extract light absorption value by Fig. 3 result to a certain degree increases as time went on, in 25It reaches peak value, is then slightly decreased within 30 days, but sense organ is better than shorter extraction time group.Steady in order to guarantee product colorFixed, selective extraction number of days of the present invention was at 15-30 days.
Further describe the present invention with reference to embodiment, the present invention is not limited only to described embodiment.