Antimicrobial seal laber of patch and its preparation method and application can repeatedly be tornTechnical field
The invention belongs to label and its field of material technology, and in particular to a kind of antimicrobial sealing mark that can repeatedly tear patchSign material, label and its preparation method and application.
Background technology
The pressure-sensitive adhesive label that body is cut out as information, is seen everywhere, basic function is to carry to be pasted in daily lifeThe information of commodity and its producer are interspersed and are beautified by patch commodity.With the development of material science, commodity and its packaged formIncreasingly varied, the higher function requirement that body label is cut out as information is also increasingly various.Therefore, the exploitation of functionality tabsIt is also diversified therewith with application, there are many functionalization labels, such as high temperature resistant labels, be subjected to freezing label, printable markLabel, organic solvent-resistant wiping label, continuous productive process process label, air guide reticulate pattern label etc..
In order to meet the needs of different purposes, industry further developed such as multiple Wet paper towel packing bag seal labers, baby childrenThe wet tissue that degreases used in the packaging bag seal laber of youngster's amenities, the packaging bag seal laber of sanltary towel, kitchenThe one kind such as packaging bag seal laber repeated multiple times can tear the seal laber of patch；This kind of label is to post one in the packaging bag of commodityOpen the pressure sensitive adhesive Sealing piece that repeated multiple times can tear patch of " sealing ".It is main to evaluate this pressure sensitive adhesive Sealing piece whether qualified oneStandard be see by repeatedly tear repeatedly patch after can or can not in commodity packaging there are residue glues；Therefore the seal laber of patch can be torn repeatedlyIt is a kind of typical adhesive functional label, there is the performance characteristic that can tear patch repeatedly.The repeated multiple times seal laber for tearing patch is answeredWhen sealing for pack content hygenic towelette etc., due to by the content of patch product there are a certain amount of moisture (such as：Water, alcohol or other liquid mediums) label cohesive force function can be offset, to which the bond strength of adhesive, therefore, viscose glue can be reducedThe viscosity of agent is an important indicator of the seal laber that can tear patch repeatedly；The existing seal laber that can tear patch repeatedly is usedAdhesive with tear patch number be incremented by and continuously decrease even lose cement properties, cause sealing function to lack.
For can repeatedly tear in the seal laber of patch applied to typical wet product, " sealing " is by film substrate pairBy the content of patch product moisture (such as：Water, alcohol or other liquid mediums) closed and barrier is carried out, film substrate has lowOxygen permeability and low-moisture permeability are to investigate the closed important indicator with barrier property of seal laber；Chinese patent applicationThe film substrate of seal laber disclosed in CN201280076406.7 is using polyolefin, polyethylene terephthalate, polychlorostyreneA kind of single layer structure in ethylene or two or more multilayered structures；Currently used this kind of film substrate oxygen permeabilityIt is too big with penetrability, cause label barrier property low, sealing effect is poor.
For personal hygiene article, such as hygenic towelette, infant's Dribble towel, sanltary towel, facial mask is nursed, and currently existTechnology, product, market still it is leaved for development tourism, health, nursing, health treatment, the health of product, sterilize and meet it is certain fromRule standard and pressure standard are inevitable, and as the seal laber that can tear patch repeatedly applied to health, sterilising prods, moreIt is secondary unpacking, closed, then break seal, it is closed again during, in addition to binder described above viscosity and film substrate it is lowOther than oxygen permeability and low-moisture permeability, the antimicrobial function of seal laber, bacteriostasis and safe and healthy it is also important indexOne of.
To sum up, the existing seal laber that can tear patch repeatedly is primarily present problems with：1) film substrate generally usedOxygen permeability and penetrability are too big, cause label barrier property low, sealing effect is poor；2) label having does not have the defence of antibiotic and sterilizingBarrier causes label repeatedly to open and is easy to by microbial attack, safe and healthy not up to standard；3) existing label through repeatedly tear open,The bonding force of adhesive, which reduces, after stickup even loses, and sealing is caused to fail；4) because the coated face surface tension of plane materiel is insufficient, whenWhen seal laber is pasted on the stratiform bag and/or container of high surface tension, it be easy to cause the multiple adhesive transfer for tearing patch simultaneouslyRemain on affixed object.
Invention content
For overcome the deficiencies in the prior art, the antimicrobial close of patch can repeatedly be torn the purpose of the present invention is to provide a kind ofLabel material is sealed, the tearable patch number and sealing effect of seal laber are improved while ensureing safe and healthy, sealing is avoided to markLabel are attached to adhesive residue on affixed object because repeatedly tearing.
To solve the above problems, the technical solution adopted in the present invention is as follows：
A kind of antimicrobial seal laber material that can repeatedly tear patch comprising：
Oxygen permeability is less than 5.0mL/ (m20.1MPa for 24 hours), penetrability be less than 5g/ (m2The PVDC that contains for 24 hours) is coated withThe film substrate of object；
Glutinous base power is more than the antimicrobial pressure sensitive adhesive compositions of 44mN/m, cohesive force more than 2N/ inches；
The release substrate of siliceous oil coating of the off-type force less than 25g/ inches.
As further embodiment, film substrate of the present invention be polyolefins, polyethylene terephthalate,Polyvinyl chloride etc., including polypropylene, polyethylene, polyester, synthesis PP, synthesis BCA in a kind of material film or two or moreCoextruded film is blended in material.
As further embodiment, antimicrobial pressure sensitive adhesive compositions of the present invention are by Acrylate pressure sensitiveThe composition of adhesive and chlorohexidene composition, the wherein a concentration of 1wt%-5wt% of chlorohexidene.
As further embodiment, Acrylic Pressure Sensitive Adhesive of the present invention is polymerize by following component by weightIt forms：
30-40 parts of acrylic acid, 20-30 parts of butyl acrylate, 50-70 parts of methyl acrylate, Isooctyl acrylate monomer 10-20Part, 2-10 parts of rosin, 5-10 parts of glycerine, 180-270 parts of ethyl acetate, 3-5 parts of initiator, isocyanate curing agent 0.7-1.5Part.
As further embodiment, the antimicrobial seal laber of the present invention that can repeatedly tear patch passes through 50-150 timesTear repeatedly and be attached on affixed object not adhesive residue.
As further embodiment, the thickness of PVDC coating material of the present invention is 0.8-3.0 μm.
Another object of the present invention is to provide a kind of preparation sides for the antimicrobial seal laber material that can repeatedly tear patchMethod obtains a kind of tearable patch often antimicrobial seal laber material that can repeatedly tear patch good with sealing effect by this methodMaterial；Scheme is as follows：
A kind of preparation method for the antimicrobial seal laber material that can repeatedly tear patch, which includes following stepSuddenly：
1) film substrate containing PVDC coating material is prepared：Film substrate is positioned over unreeling for double coating head web coatable machinesOn station, it is coated with silane coupling agent formation priming coat on the first web coatable device, passes through the second reticulate pattern after drying on priming coatApparatus for coating line is coated with PVDC coating material and baking and curing；Then on double coating head web coatable machines line cool down, wind fromLine is positioned in 40-60 DEG C of environment and cures 40-50h, obtains the film substrate containing PVDC coating material；
2) antimicrobial pressure sensitive adhesive compositions are prepared：Acrylic Pressure Sensitive Adhesive is mixed with chlorohexidene anti-Microorganism pressure sensitive adhesive compositions；
3) the antimicrobial seal laber material of patch can repeatedly be torn by preparing：By coating machine by antimicrobial pressure-sensitive adhesiveIt is coated on release substrate, baking and curing forms antimicrobial formation of pressure-sensitive adhesive layer, then contains PVDC by what step 1) obtainedOn compound to the antimicrobial formation of pressure-sensitive adhesive layer of film substrate of coating material, pass through the composite pressure of coating machine and release substrateAntimicrobial formation of pressure-sensitive adhesive layer is transferred to the film substrate layer containing PVDC coating material by off-type force, cold by coating machine lineBut device cools down, and winds, is offline, is positioned over 45-55 DEG C of environment curing 120-150h, obtains repeatedly tearing the antimicrobial close of patchSeal label material.
As further embodiment, Acrylic Pressure Sensitive Adhesive by pressing below in the step 2) described in above-mentioned preparation methodWeight meter component is polymerized：
30-40 parts of acrylic acid, 20-30 parts of butyl acrylate, 50-70 parts of methyl acrylate, Isooctyl acrylate monomer 10-20Part, 2-10 parts of rosin, 5-10 parts of glycerine, 180-270 parts of ethyl acetate, 3-5 parts of initiator, isocyanate curing agent 0.7-1.5Part；
The specific preparation method of antimicrobial pressure sensitive adhesive compositions is as follows；
a：1-3 parts of initiators are dissolved into 30-50 parts of ethyl acetate solutions, the propylene of formula ratio is then sequentially addedAcid, butyl acrylate, methyl acrylate, Isooctyl acrylate monomer, glycerine obtain mixed liquor after being thoroughly mixed uniformly；
b：30-50 parts of ethyl acetate are added in reactor and are warming up to 76-80 DEG C, 1/2 is slowly added dropwise after reflux is stablizedThe above-mentioned mixed liquor of volume is stirred to react 1.5-2 hours at 80-82 DEG C；
c:Remaining initiator is dissolved in the ethyl acetate solution for forming initiator in remaining ethyl acetate, and this is drawnSend out the ethyl acetate solution reaction system for being slowly added drop-wise to step 2) synchronous with the above-mentioned remaining mixed liquor of 1/2 volume of agentIn, continue that 2-10 part of rosin milk is added dropwise into reaction system after dripping, the reaction was continued that 0.5-1.5 is small for 80-82 DEG C of holdingWhen, obtain Acrylic Pressure Sensitive Adhesive；
d：After Acrylic Pressure Sensitive Adhesive is cooled to room temperature, 3-5 parts of chlorhexidine gluconates are added dropwise to get micro- to resistingBiological pressure sensitive adhesive compositions.
e：Before being coated with antimicrobial pressure sensitive adhesive compositions by isocyanate curing agent 0.7-1.5 parts be added to combinationIn object, homogenizer stirs 15-25 minutes, stands 10-20 minutes.
As further embodiment, the thickness of priming coat of the present invention is 0.2-0.5 μm；The PVDC coating materialThickness be 0.8-3.0 μm, the thickness of antimicrobial formation of pressure-sensitive adhesive layer is 12-30 μm.
Third object of the present invention is to provide a kind of tearable patch often with sealing effect it is good can repeatedly tear the anti-of patchMicroorganism-tight label, while adhesive residue on affixed object can be attached to avoid because repeatedly tearing.
A kind of antimicrobial seal laber that can repeatedly tear patch is by the anti-micro- life of the present invention that can repeatedly tear patchWhat object seal laber material was formed after printing, being die cut.
Fourth object of the present invention is the antimicrobial seal laber that can repeatedly tear patch in layer structure packetApplication in pack or packing container.It can repeatedly tear what the antimicrobial seal laber of patch was open for packaging bag or packing containerSealing.
The 5th of the present invention is designed to provide a kind of packaging including the antimicrobial seal laber that can repeatedly tear patchContainer, scheme are as follows：
A kind of packaging bag or packing container comprising packaging bag body or packing container ontology, the packaging bag body orPacking container ontology is equipped with the opening for picking and placeing content, the opening anti-micro- life of the present invention that can repeatedly tear patchObject seal laber seals.
Compared with prior art, the beneficial effects of the present invention are：
1. the film substrate of the antimicrobial seal laber material of the present invention that can repeatedly tear patch is coated with by PVDCObject is coated with, and reaches oxygen permeability and the low film substrate of penetrability, and can effectively improve seal laber containing PVDC coating materialObstruct the performance and sealing effect of moisture and oxygen；
2. containing antimicrobial pressure-sensitive adhesive in the antimicrobial seal laber material of the present invention that can repeatedly tear patchAgent composition can effectively improve tearable patch number, set up defensive barrier, it is ensured that microorganism is not easy to invade, and there is antibiotic and sterilizing to makeWith, ensure the safety and sanitation of packing material, while it is possible to prevente effectively from packing container or packaging bag adhesive residue.
Invention is further described in detail With reference to embodiment.
Description of the drawings
Fig. 1 be 10 groups of antimicrobial pressure sensitive adhesive seal labers of the present invention testing respectively of Quine's method it is antimicrobial andBacteriostasis result.
Specific implementation mode
" adherend " or " affixed object " appeared in the present invention refer to it is of the present invention with it is of the present invention can be moreThe object of bonding or the fitting of the secondary antimicrobial seal laber for tearing patch, such as can be stratiform packaging bag or packing container.
Term " antimicrobial ", " antibacterial " and " mould proof " used in the present invention, describes to bacterium, yeast, fungiOr algae killing and to the inhibition of growth and prevent growth；Term " antimicrobial pressure sensitive adhesive compositions " refer toThe dosage broad-spectrum antimicrobial agent, the dosage broad-spectrum antimicrobial agent are mixed in Acrylic Pressure Sensitive AdhesiveThe composition formed with Acrylic Pressure Sensitive Adhesive exists with the service life of seal laber, and to seal laber and its is pastedObject plays antimicrobial, antibacterial, mildew-proof function.
The antimicrobial seal laber material of the present invention that patch can repeatedly be torn comprising：
Oxygen permeability is less than 5.0mL/ (m20.1MPa for 24 hours), penetrability be less than 5g/ (m2The PVDC that contains for 24 hours) is coated withThe film substrate of object；
Glutinous base power is more than the antimicrobial pressure sensitive adhesive compositions of 44mN/m, cohesive force more than 2N/ inches；
The release substrate of siliceous oil coating of the off-type force less than 25g/ inches.
PVDC resins are as composite material or monomer material and coextruded film, and PVDC is since its intermolecular cohesive force is strong, knotBrilliant degree is high, and the chlorine atom in PVDC molecules has hydrophobicity, will not form hydrogen bond, oxygen molecule and hydrone are difficult in PVDC moleculesIt is mobile, it is moist to make it have excellent oxygen barrier and resistance, and its oxygen barrier is not influenced by ambient humidity；NamelyIt says, under the conditions of any temperature and humidity, has both the ability of remarkable barrier steam, oxygen, smell and fragrance.It is of the present inventionPVDC be high-molecular compound polyvinylidene chloride abbreviation, since polyvinylidene chloride homopolymer thermal stability is poor, moldingPoor processability may not apply to conventional plastics processing method machine-shaping, so, in the present invention by being by PVDCPVDC latex is coated on polyolefins, polyethylene terephthalate etc. comprising poly- by the coating process of vinylidene chloride routinePropylene, polyethylene, polyester, polyvinyl chloride, PP synthesis, BCA are synthesized and its are blended on any one film of coextruded film and formedThe PVDC film layers of highly crystalline.Find that PVDC is coated on film substrate in the research of the present invention, with the poly- of biaxial tensionFor Polypropylene film, its oxygen transmission rate reduces by 1000 times after coating, and permeability rate reduces by 3 times；Coating can be general single with single-layer or multi-layerLayer can be obtained good barrier applied to 2 μm.Using the film substrate containing PVDC coating material with good in the present inventionGas barrier property and resistance are moist, and wherein gas barrier property is the generation for referring to delay the content oxidation deterioration phenomenon of packaging, can be avoidedThe intrusion of the content of packaging, especially fragrance and alcohol scattered and disappeared and obstruct external peculiar smell；It is to refer to prevent from packing to hinder moistContent, especially high moisture content, high alcohol-content, liquor aromas etc. occur dehydration and are dried, and prevent quantitative product from nature damage occursIt consumes (weightlessness).In addition, being dry products, such as sanltary towel, baby paper diaper, PVDC moisture barrier properties for pack contentEnough outside moisture is prevented to invade, moreover, the gas barrier properties of PVDC of the present invention do not change because of the variation of ambient humidity, i.e.,Make the rotten and variable for also not causing content in hot and humid environment.
As further embodiment, film substrate of the present invention be polyolefins, polyethylene terephthalate,Polyvinyl chloride etc., including polypropylene, polyethylene, polyester, synthesis PP, synthesis BCA in a kind of material film or two or moreCoextruded film is blended in material.
In the present invention, due to being less than 5.0mL/ (m using oxygen permeability20.1MPa for 24 hours), penetrability be less than 5g/(m2The film substrate containing PVDC coating material for 24 hours) is directly exposed to sunlight even if being chronically exposed to outdoor, will notLabel colour fading or aging phenomenon, safety and environmental protection occurs, and is food, medicine by FDA (U.S. Food and Drug Administration) certificationProduct, nursing health products packaging escort safely.
" glutinous base power (keying) " specifically refer to adhesive and base material or adhesive and silane coupling agent and silane coupling agent and base material itBetween cohesive force.Glutinous base power of the present invention, refer to by the antimicrobial pressure-sensitive adhesive and base material or adhesive withBonding strength between silane coupling agent and silane coupling agent and base material.Base material or surface free energy coated on the silane coupling agent above base materialThe cohesive strength of size and the antimicrobial pressure-sensitive adhesive is the essential condition for determining to stick base power size.In existing skillIn art, pressure-sensitive adhesive label is formed as to oneself, glutinous base power size can not be characterized with test.It finds, presses in the present invention studiesThe glutinous base power of quick glue product needs to be characterized with the surface tension mN/m (dyne) of base material (and/or silane coupling agent).It is of the present inventionGlutinous base power be more than 44mN/m, be that the antimicrobial seal laber that can repeatedly tear patch is pasted on surface tension to be more than44mN/m, i.e. 46mN/m be either on the breadboard of 48mN/m or 50mN/m, then passes through 66 DEG C, the high temperature of relative humidity 80%The degradation of high humidity 48-96h, and label is removed from breadboard with the angle of the rate of 5-50/s and 120 ° or so,It tests with this and confirms that the adhesive for the antimicrobial seal laber that can repeatedly tear patch does not remain on affixed object, and pass throughThe experiment of high temperature and humidity and 48-96h were come prejudge that the seal laber is pasted on the packaging bag and packing container 1 year and 2 yearsPeriod in whether adhesive residue referring in detail to the present inventor on affixed object in the present invention in (on the same day applying《Pressure-sensitive adhesiveProduct residue glue rank test method》).It can be seen that glutinous base power of the present invention can be multiple for described more than 44mN/mThe antimicrobial seal laber for tearing patch is pasted on the packaging bag and packing container through 1-150 unlatching, closed, be then turned on,Closed sealing applications are beneficial again.
Cohesive force of the present invention is more than 2N/ inches of antimicrobial pressure sensitive adhesive seal laber, is particularly applied to wrapWhen content-filled sealing for hygenic towelette etc., due to by the content of patch product there are a certain amount of moisture (such as：Water, alcoholOr other liquid mediums) label cohesive force function can be offset, to which the bonding strength of adhesive can be reduced；Meanwhile the sealingLabeling requirement is repeatedly torn label and paste after through long period (such as Product transport way or product wait for pin, including half a year in libraryOr 1 year or even longer period) and therefore cohesive force cannot reduce or the patch seal laber of repeatedly tearing such as become largerCharacteristic, and be different from certain pressure-sensitive adhesive labels of the prior art, cohesive force is the bigger the better or label paste after with the timePassage cohesive force is with becoming larger.The patch seal laber such as cohesive force of the present invention that repeatedly tears declines, and the sealing function of label will loseIt loses；As cohesive force becomes larger, or after label stickup through long period due to become larger, by the unlatching of label, closed, be then turned on, be close againIt closes and causes difficulty, particularly with the packaging bag of layer structure, the change of label cohesive force will tear greatly packaging bag, and sealing is made to fail.ThisThe invention seal laber that can repeatedly tear patch, described in cohesive force be more than 2N/ inches or 2.5-10N/ inches, beIt is realized by the adjusting of Acrylic Pressure Sensitive Adhesive disclosed in this invention and its component amount, and is more than with the glutinous base power44mN/m and formula middle-molecular-weihydroxyethyl is small realizes that the cohesive force is more than 2N/ inches, and its according to the 2.5-10N/ inches of designRelative constant cohesive force, and not because repeatedly tear patch due to reduce or prolonged period and become larger.
As further embodiment, antimicrobial pressure sensitive adhesive compositions of the present invention are by Acrylate pressure sensitiveThe composition of adhesive and chlorohexidene composition, the wherein a concentration of 1wt%-5wt% of chlorohexidene.
Chlorohexidene also known as Chlorhexidine of the present invention, chemical name 1, bis- (n- to the chlorobenzene biguanides) hexanes of 6-, also known asChlorhexidine.So-called guanidine can regard that the oxygen atom in urea molecular structure (- NH-C0-NH-) is taken by imino group (=NH) asGeneration and the compound generated, the group after a hydrogen atom are removed in guanidine molecule guanidine radicals, guanidine radicals is the feature function of chlorohexideneGroup.Due to the presence of imido group, chlorohexidene sheet since it is difficult to ionize, thus is insoluble in water as alkaline matter.But it canWith inorganic acid chlorhexidine salt, the presence of stabilization soluble in water are formed such as acetic acid, hydrochloric acid or organic acid, such as gluconic acid.It washesSafe must be reacted with different acid, obtain different salt, as and acetic acid reaction, obtain chlorhexidine acetate (ChlorhexidineAcetate, CHA)；It is reacted with hydrochloric acid, obtains chlorhexidine hydrochloride (Chlorhexidine hydrochloride, CHH)；With PortugalGrape saccharic acid reacts, and obtains chlorhexidine gluconate (Chlorhexidine Gluconate, CHG).Being washed at the acetic acid after salt mustThailand, chlorhexidine hydrochloride, chlorhexidine gluconate are neutral substance.Wherein with the water solubility of chlorhexidine gluconate maximum(20%), secondly it is chlorhexidine acetate (1.8%), chlorhexidine hydrochloride (0.06%), it is preferred that chlorohexidene of the present inventionFor chlorhexidine gluconate.
As further embodiment, Acrylic Pressure Sensitive Adhesive of the present invention is polymerize by following component by weightIt forms：
30-40 parts of acrylic acid, 20-30 parts of butyl acrylate, 50-70 parts of methyl acrylate, Isooctyl acrylate monomer 10-20Part, 2-10 parts of rosin, 5-10 parts of glycerine, 180-270 parts of ethyl acetate, 3-5 parts of initiator, isocyanate curing agent 0.7-1.5Part.
The present invention has found that the cohesive force and viscous-elastic behaviour of adhesive and the molecular size range of monomer are close in the course of the researchThe molecular weight of correlation, monomer is small, and cohesive force is low, and viscous-elastic behaviour is high, such as：Acrylic acid (molecular weight 72.06), methyl acrylate(molecular weight 86.09), glycerine (molecular weight 92.09), butyl acrylate (molecular weight 128.17), Isooctyl acrylate monomer (molecular weight184.28), rosin (molecular weight 302.46)；The seal laber of the present invention that patch can repeatedly be torn, described in cohesive force it is bigIn 2N/ inches, 2.5-10N/ inches, realized by the adjusting of the component amount of the rosin resin of the tackifying resin of high molecular weight, the seal laber bonding that can repeatedly tear patch is effectively realized in the addition of the rosin resin of the tackifying resin of high molecular weightPower especially effectively realizes the seal laber that can repeatedly tear patch by the adjusting of the component amount to viscosifying rosin resinCohesive force from 2.0-10N/ inches of adjustable range；Cohesive force is not reduced significantly because tearing patch (50-150 times) repeatedly.ButIt is, it should be noted that the addition of tackifying resin needs to control in a certain range, and otherwise seal laber pastes prolonged periodAfterwards, difficulty will be caused for the unlatching of seal laber；Due to chlorhexidine gluconate (CHG, the molecular weight of antimicrobial property111.549) molecular weight is small, and content is high in component, and antimicrobial, antibacterial, mould proof characteristic significantly improves, the seal laberSignificantly extend with affixed object surface antimicrobial, antibacterial, mould proof effective period；But the small feature of its CHG molecular weight, works as mixingSo that the glutinous body of viscous-elastic behaviour is softened in the component of acrylate adhesive, the creep resistance of pressure sensitive adhesive is made to decline.Therefore,It can make each acrylate monomer molecule and the CHG in component by adjusting the dosage of the component of isocyanates in the present inventionMolecule is full cross-linked, realizes that the hardness for sticking body improves, to make the creep resistance of pressure sensitive adhesive significantly improve, meets and resist micro- lifeObject can repeatedly tear the functional characteristic of the seal laber of patch, and realize the gluing with the antimicrobial seal laber that can repeatedly tear patchThe viscous-elastic behaviour of agent meets small dB (Decibel) decibels for repeatedly tearing patch process softness.
By the important intermediate performance of the organic synthesis object of isocyanates, enhancing Acrylic Pressure Sensitive Adhesive is to filmThe throwing anchor-hold of base material makes Acrylic Pressure Sensitive Adhesive stick base power and is more than 44mN/m, contains acrylate pressure-sensitive adhesive to realizeThe glutinous base power that stick and chlorohexidene form the antimicrobial pressure-sensitive adhesive that composition is formed is more than 44mN/m, makes this hairThe bright antimicrobial seal laber that can repeatedly tear patch tears to be attached on affixed object and does not remain gluing repeatedly by 1-150 timesAgent.
As further embodiment, the thickness of PVDC coating material of the present invention is 0.8-3.0 μm.
Another object of the present invention is to provide a kind of preparation sides for the antimicrobial seal laber material that can repeatedly tear patchMethod obtains a kind of tearable patch often antimicrobial seal laber material that can repeatedly tear patch good with sealing effect by this methodMaterial；Scheme is as follows：
A kind of preparation method for the antimicrobial seal laber material that can repeatedly tear patch, which includes following stepSuddenly：
1) film substrate containing PVDC coating material is prepared：Film substrate is positioned over unreeling for double coating head web coatable machinesOn station, it is coated with silane coupling agent formation priming coat on the first web coatable device, passes through the second reticulate pattern after drying on priming coatApparatus for coating line is coated with PVDC coating material and baking and curing；Then on double coating head web coatable machines line cool down, wind fromLine is positioned in 40-60 DEG C of environment and cures 40-50h, obtains the film substrate containing PVDC coating material；
2) antimicrobial pressure sensitive adhesive compositions are prepared：Acrylic Pressure Sensitive Adhesive is mixed with chlorohexidene anti-Microorganism pressure sensitive adhesive compositions；
3) the antimicrobial seal laber material of patch can repeatedly be torn by preparing：By coating machine by antimicrobial pressure-sensitive adhesiveIt is coated on release substrate, baking and curing forms antimicrobial formation of pressure-sensitive adhesive layer, then contains PVDC by what step 1) obtainedOn compound to the antimicrobial formation of pressure-sensitive adhesive layer of film substrate of coating material, pass through the composite pressure of coating machine and release substrateAntimicrobial formation of pressure-sensitive adhesive layer is transferred to the film substrate layer containing PVDC coating material by off-type force, cold by coating machine lineBut device cools down, and winds, is offline, is positioned over 45-55 DEG C of environment curing 120-150h, obtains repeatedly tearing the antimicrobial close of patchSeal label material.
In the preparation method of the antimicrobial seal laber material of the present invention that can repeatedly tear patch, the filmBase material before the coating, must be surface-treated, and to reach surface state good enough, guarantee obtains continuous, pin-freePVDC coatings and PVDC coatings are the same as having good binding strength between film substrate.Film substrate is surface-treated common methodThere are sided corona treatment and primer coating two major classes, sided corona treatment that the surface of film substrate can be made to chemically react, generate polar groupGroup, increases the surface tension of film substrate, contributes to PVDC latex in the infiltration on film substrate surface, improves Painting effect；When sided corona treatment, it can also make to generate certain roughening effect on the surface of film substrate, so as to improve between coating and film substrateBond strength.But for low-surface-energy and nonpolar film substrate, passage that sided corona treatment effect can be at any time and go outLose, especially, PVDC latex is polar molecule, surface tension between 40-44mN/m, in conjunction with two-phase surface tension answer phaseTo balance.So polyurethane silane coupling agent of the present invention be then by specific coating formed silane coupling agent, make film substrate andPVDC applies the combination of interlayer, the combination of the combination and silane coupling agent and PVDC coatings for silane coupling agent and film substrate is changed, to protectThe permanent firmness of PVDC coatings is demonstrate,proved, and not because of hot and humid environment, the dipping of especially high alcohol environment and coating shedding.
The silane coupling agent of the present invention can be selected from vinyl group resin, polyurethanes copolymer, polyolefin copolymers, propyleneAny one of or mixtures thereof acid copolymer,.The selection and use of silane coupling agent are proper, and PVDC Painting effects can be made brightIt is aobvious to be promoted.Preferably, silane coupling agent of the present invention is selected from polyurethanes silane coupling agent.It is of the present invention in further embodimentPriming coat thickness be 0.2-0.5 μm.
Since PVDC coating layer thicknesses and drying condition have its substantial connection, the coating being disposably coated with is too thick, be easy to causeSurface drying and form coating cracking, destroy barrier property, and PVDC coating thickness becomes direct ratio with barrier property, coating layer thickness is got overThickness, barrier property are higher.So to obtain extraordinary barrier property, may be used double spread, two-sided secondary coating workSkill.The coating thickness of PVDC coating material of the present invention is 0.8-3.0 microns, can pass through a single side or primary two-sided paintingCloth technique.
As further embodiment, the thickness of the antimicrobial formation of pressure-sensitive adhesive layer is 12-30 μm.
As further embodiment, Acrylic Pressure Sensitive Adhesive by pressing below in the step 2) described in above-mentioned preparation methodWeight meter component is polymerized：
30-40 parts of acrylic acid, 20-30 parts of butyl acrylate, 50-70 parts of methyl acrylate, Isooctyl acrylate monomer 10-20Part, 2-10 parts of rosin, 5-10 parts of glycerine, 180-270 parts of ethyl acetate, 3-5 parts of initiator, isocyanate curing agent 0.7-1.5Part；
The specific preparation method of antimicrobial pressure sensitive adhesive compositions is as follows；
a：1-3 parts of initiators are dissolved into 30-50 parts of ethyl acetate solutions, the propylene of formula ratio is then sequentially addedAcid, butyl acrylate, methyl acrylate, Isooctyl acrylate monomer, glycerine obtain mixed liquor after being thoroughly mixed uniformly；
b：30-50 parts of ethyl acetate are added in reactor and are warming up to 76-80 DEG C, 1/2 is slowly added dropwise after reflux is stablizedThe above-mentioned mixed liquor of volume is stirred to react 1.5-2 hours at 80-82 DEG C；
c:Remaining initiator is dissolved in the ethyl acetate solution for forming initiator in remaining ethyl acetate, and this is drawnSend out the ethyl acetate solution reaction system for being slowly added drop-wise to step 2) synchronous with the above-mentioned remaining mixed liquor of 1/2 volume of agentIn, continue that 5-10 part of rosin milk is added dropwise into reaction system after dripping, the reaction was continued that 0.5-1.5 is small for 80-82 DEG C of holdingWhen, obtain Acrylic Pressure Sensitive Adhesive；
d：After Acrylic Pressure Sensitive Adhesive is cooled to room temperature, 3-5 parts of chlorhexidine gluconates are added dropwise to get micro- to resistingBiological pressure sensitive adhesive compositions.
e：Before being coated with antimicrobial pressure sensitive adhesive compositions by isocyanate curing agent 0.7-1.5 parts be added to combinationIn object, homogenizer stirs 15-25 minutes, stands 10-20 minutes.
Third object of the present invention is to provide a kind of tearable patch often with sealing effect it is good can repeatedly tear the anti-of patchMicroorganism-tight label, while adhesive residue on affixed object can be attached to avoid because repeatedly tearing.
A kind of antimicrobial seal laber that can repeatedly tear patch is by the anti-micro- life of the present invention that can repeatedly tear patchWhat object seal laber material was formed after printing, being die cut.
Fourth object of the present invention is the antimicrobial seal laber that can repeatedly tear patch in layer structure packetApplication in pack or packing container.It can repeatedly tear what the antimicrobial seal laber of patch was open for packaging bag or packing containerSealing.
The 5th of the present invention is designed to provide a kind of packaging including the antimicrobial seal laber that can repeatedly tear patchContainer, scheme are as follows：
A kind of packaging bag or packing container comprising packaging bag body or packing container ontology, the packaging bag body orPacking container ontology is equipped with the opening for picking and placeing content, the opening anti-micro- life of the present invention that can repeatedly tear patchObject seal laber seals.
Specific embodiment of the present invention below, in the following embodiments used by equipment, raw material and reagentTo be obtained by commercial channel.
Embodiment 1
A kind of antimicrobial seal laber material that can repeatedly tear patch is prepared by the following method：
1) film substrate containing PVDC coating material is prepared：Film substrate is positioned over unreeling for double coating head web coatable machinesOn station, on the first web coatable device being coated with polyurethane silane coupling agent forms priming coat, by the on priming coat after dryingTwo web coatable device lines are coated with PVDC coating material and baking and curing；Then line cools down on double coating head web coatable machines,Winding is offline, is positioned in 40 DEG C of environment and cures 50h, obtains the film substrate containing PVDC coating material；
2) antimicrobial pressure sensitive adhesive compositions are prepared：Acrylic Pressure Sensitive Adhesive is mixed with chlorohexidene anti-Microorganism pressure sensitive adhesive compositions；
Acrylic Pressure Sensitive Adhesive is polymerized by following component by weight：
It is 30 parts of acrylic acid, 20 parts of butyl acrylate, 50 parts of methyl acrylate, 10 parts of Isooctyl acrylate monomer, 3 parts of rosin, sweet5 parts of oil, 180 parts of ethyl acetate, 3 parts of initiator, 0.7 part of isocyanate curing agent；
The specific preparation method of antimicrobial pressure sensitive adhesive compositions is as follows；
a：1 part of initiator is dissolved into 30 parts of ethyl acetate solutions, acrylic acid, the propylene of formula ratio are then sequentially addedAcid butyl ester, methyl acrylate, Isooctyl acrylate monomer, glycerine obtain mixed liquor after being thoroughly mixed uniformly；
b：30 parts of ethyl acetate are added in reactor and are warming up to 76 DEG C, 1/2 volume is slowly added dropwise after reflux is stablizedAbove-mentioned mixed liquor is stirred to react 1.5 hours at 80 DEG C；
c:Remaining initiator is dissolved in the ethyl acetate solution for forming initiator in remaining ethyl acetate, and this is drawnSend out the ethyl acetate solution reaction system for being slowly added drop-wise to step 2) synchronous with the above-mentioned remaining mixed liquor of 1/2 volume of agentIn, continue that rosin milk is added dropwise into reaction system after dripping, being kept for 80 DEG C, the reaction was continued 0.5 hour, obtains acrylatePressure-sensitive adhesive；
d：After Acrylic Pressure Sensitive Adhesive is cooled to room temperature, 3 parts of chlorhexidine gluconates are added dropwise to get to anti-micro- lifeObject pressure sensitive adhesive compositions.
e：Isocyanate curing agent is added in composition before being coated with antimicrobial pressure sensitive adhesive compositions, high speedBlender stirs 15 minutes, stands 10 minutes.
3) the antimicrobial seal laber material of patch can repeatedly be torn by preparing：By coating machine by antimicrobial pressure-sensitive adhesiveIt is coated on release substrate, baking and curing forms antimicrobial formation of pressure-sensitive adhesive layer, then contains PVDC by what step 1) obtainedOn compound to the antimicrobial formation of pressure-sensitive adhesive layer of film substrate of coating material, pass through the release of the composite pressure of coating machine and substrateAntimicrobial formation of pressure-sensitive adhesive layer is transferred to the film substrate layer containing PVDC coating material by power, is cooled down and is filled by coating machine lineCooling is set, winds, is offline, 45 DEG C of environment curing 150h is positioned over, obtains the antimicrobial seal laber material that can repeatedly tear patch.
By test, by the antimicrobial seal laber material obtained by the above method that can repeatedly tear patch, containingThe oxygen permeability of the film substrate of PVDC coating material is 4.5mL/ (m20.1MPa for 24 hours), penetrability be less than 4.8g/ (m2·24h)；
The glutinous base power of antimicrobial pressure sensitive adhesive compositions is 46mN/m, cohesive force is 4.8N/ inches；
The off-type force of the release substrate of siliceous oil coating is 12g/ inches；
The thickness of the priming coat is 0.4 μm；The thickness of the PVDC coating material is 1.5 μm, antimicrobial pressure sensitive adhesiveThe thickness of adhesive layer is 18 μm.
Application Example 1
By embodiment 1 it is obtained can repeatedly tear patch antimicrobial seal laber material by printing trade mark or pattern,It obtains repeatedly tearing the antimicrobial seal laber of patch after cross cutting, and the label is affixed on to the opening of baby paper diaper packaging bagPlace.
Embodiment 2
A kind of antimicrobial seal laber material that can repeatedly tear patch is prepared by the following method：
1) film substrate containing PVDC coating material is prepared：Film substrate is positioned over unreeling for double coating head web coatable machinesOn station, on the first web coatable device being coated with polyurethane silane coupling agent forms priming coat, by the on priming coat after dryingTwo web coatable device lines are coated with PVDC coating material and baking and curing；Then line cools down on double coating head web coatable machines,Winding is offline, is positioned in 45 DEG C of environment and cures 45h, obtains the film substrate containing PVDC coating material；
2) antimicrobial pressure sensitive adhesive compositions are prepared：Acrylic Pressure Sensitive Adhesive is mixed with chlorohexidene anti-Microorganism pressure sensitive adhesive compositions；
Acrylic Pressure Sensitive Adhesive is polymerized by following component by weight：
It is 35 parts of acrylic acid, 25 parts of butyl acrylate, 55 parts of methyl acrylate, 15 parts of Isooctyl acrylate monomer, 5 parts of rosin, sweet6 parts of oil, 200 parts of ethyl acetate, 4 parts of initiator, 1 part of isocyanate curing agent；
The specific preparation method of antimicrobial pressure sensitive adhesive compositions is as follows；
a：2 parts of initiators are dissolved into 40 parts of ethyl acetate solutions, acrylic acid, the propylene of formula ratio are then sequentially addedAcid butyl ester, methyl acrylate, Isooctyl acrylate monomer, glycerine obtain mixed liquor after being thoroughly mixed uniformly；
b：40 parts of ethyl acetate are added in reactor and are warming up to 76 DEG C, 1/2 volume is slowly added dropwise after reflux is stablizedAbove-mentioned mixed liquor is stirred to react 1.5 hours at 82 DEG C；
c:Remaining initiator is dissolved in the ethyl acetate solution for forming initiator in remaining ethyl acetate, and this is drawnSend out the ethyl acetate solution reaction system for being slowly added drop-wise to step 2) synchronous with the above-mentioned remaining mixed liquor of 1/2 volume of agentIn, continue that rosin milk is added dropwise into reaction system after dripping, being kept for 82 DEG C, the reaction was continued 1 hour, obtains acrylate pressureSensitive adhesive；
d：After Acrylic Pressure Sensitive Adhesive is cooled to room temperature, 4 parts of chlorhexidine gluconates are added dropwise to get to anti-micro- lifeObject pressure sensitive adhesive compositions.
e：Isocyanate curing agent is added in composition before being coated with antimicrobial pressure sensitive adhesive compositions, high speedBlender stirs 20 minutes, stands 15 minutes.
3) the antimicrobial seal laber material of patch can repeatedly be torn by preparing：By coating machine by antimicrobial pressure-sensitive adhesiveIt is coated on release substrate, baking and curing forms antimicrobial formation of pressure-sensitive adhesive layer, then contains PVDC by what step 1) obtainedOn compound to the antimicrobial formation of pressure-sensitive adhesive layer of film substrate of coating material, pass through the release of the composite pressure of coating machine and substrateAntimicrobial formation of pressure-sensitive adhesive layer is transferred to the film substrate layer containing PVDC coating material by power, is cooled down and is filled by coating machine lineCooling is set, winds, is offline, 50 DEG C of environment curing 130h is positioned over, obtains the antimicrobial seal laber material that can repeatedly tear patch.
By test, by the antimicrobial seal laber material obtained by the above method that can repeatedly tear patch, containingThe oxygen permeability of the film substrate of PVDC coating material is 4.3mL/ (m20.1MPa for 24 hours), penetrability be less than 4.9g/ (m2·24h)；
The glutinous base power of antimicrobial pressure sensitive adhesive compositions is 46mN/m, cohesive force is 5.5N/ inches；
The off-type force of the release substrate of siliceous oil coating is 16g/ inches；
The thickness of the priming coat is 0.3 μm；The thickness of the PVDC coating material is 1.5 μm, antimicrobial pressure sensitive adhesiveThe thickness of adhesive layer is 20 μm.
Application Example 2
By embodiment 2 it is obtained can repeatedly tear patch antimicrobial seal laber material by printing trade mark or pattern,It obtains repeatedly tearing the antimicrobial seal laber of patch after cross cutting, and the label is affixed on to the opening of moisture saver mask packaging bag.
Embodiment 3
A kind of antimicrobial seal laber material that can repeatedly tear patch, is prepared by the following method：
1) film substrate containing PVDC coating material is prepared：Film substrate is positioned over unreeling for double coating head web coatable machinesOn station, on the first web coatable device being coated with polyurethane silane coupling agent forms priming coat, by the on priming coat after dryingTwo web coatable device lines are coated with PVDC coating material and baking and curing；Then line cools down on double coating head web coatable machines,Winding is offline, is positioned in 55 DEG C of environment and cures 48h, obtains the film substrate containing PVDC coating material；
2) antimicrobial pressure sensitive adhesive compositions are prepared：Acrylic Pressure Sensitive Adhesive is mixed with chlorohexidene anti-Microorganism pressure sensitive adhesive compositions；
Acrylic Pressure Sensitive Adhesive is polymerized by following component by weight：
It is 28 parts of acrylic acid, 28 parts of butyl acrylate, 65 parts of methyl acrylate, 18 parts of Isooctyl acrylate monomer, 6 parts of rosin, sweet8 parts of oil, 250 parts of ethyl acetate, 4 parts of initiator, 1.2 parts of isocyanate curing agent；
The specific preparation method of antimicrobial pressure sensitive adhesive compositions is as follows；
a：2 parts of initiators are dissolved into 45 parts of ethyl acetate solutions, acrylic acid, the propylene of formula ratio are then sequentially addedAcid butyl ester, methyl acrylate, Isooctyl acrylate monomer, glycerine obtain mixed liquor after being thoroughly mixed uniformly；
b：50 parts of ethyl acetate are added in reactor and are warming up to 78 DEG C, 1/2 volume is slowly added dropwise after reflux is stablizedAbove-mentioned mixed liquor is stirred to react 2 hours at 80 DEG C；
c:Remaining initiator is dissolved in the ethyl acetate solution for forming initiator in remaining ethyl acetate, and this is drawnSend out the ethyl acetate solution reaction system for being slowly added drop-wise to step 2) synchronous with the above-mentioned remaining mixed liquor of 1/2 volume of agentIn, continue that rosin milk is added dropwise into reaction system after dripping, being kept for 80 DEG C, the reaction was continued 1.2 hours, obtains acrylatePressure-sensitive adhesive；
d：After Acrylic Pressure Sensitive Adhesive is cooled to room temperature, 2 parts of chlorhexidine gluconates are added dropwise to get to anti-micro- lifeObject pressure sensitive adhesive compositions.
e：Isocyanate curing agent is added in composition before being coated with antimicrobial pressure sensitive adhesive compositions, high speedBlender stirs 25 minutes, stands 20 minutes.
3) the antimicrobial seal laber material of patch can repeatedly be torn by preparing：By coating machine by antimicrobial pressure-sensitive adhesiveIt is coated on release substrate, baking and curing forms antimicrobial formation of pressure-sensitive adhesive layer, then contains PVDC by what step 1) obtainedOn compound to the antimicrobial formation of pressure-sensitive adhesive layer of film substrate of coating material, by the composite pressure of coating machine and release paper fromAntimicrobial formation of pressure-sensitive adhesive layer is transferred to the film substrate layer containing PVDC coating material by type power, is cooled down by coating machine lineDevice cools down, and winds, is offline, is positioned over 52 DEG C of environment curing 144h, obtains the antimicrobial seal laber material that can repeatedly tear patchMaterial.
By test, by the antimicrobial seal laber material obtained by the above method that can repeatedly tear patch, containingThe oxygen permeability of the film substrate of PVDC coating material is 3.9mL/ (m20.1MPa for 24 hours), penetrability be 4.1g/ (m2·24h)；
The glutinous base power of antimicrobial pressure sensitive adhesive compositions is 48mN/m, cohesive force is 5.8N/ inches；
The off-type force of the release substrate of siliceous oil coating is 15g/ inches；
The thickness of the priming coat is 0.4 μm；The thickness of the PVDC coating material is 2.0 μm, antimicrobial pressure sensitive adhesiveThe thickness of adhesive layer is 25 μm.
Application Example 3
By embodiment 3 it is obtained can repeatedly tear patch antimicrobial seal laber material by printing trade mark or pattern,It obtains repeatedly tearing the antimicrobial seal laber of patch after cross cutting, and the label is affixed on sanltary towel packaging bag and dry towelOpening on packing container.
Embodiment 4
A kind of antimicrobial seal laber material that can repeatedly tear patch is prepared by the following method：
1) film substrate containing PVDC coating material is prepared：Film substrate is positioned over unreeling for double coating head web coatable machinesOn station, on the first web coatable device being coated with polyurethane silane coupling agent forms priming coat, by the on priming coat after dryingTwo web coatable device lines are coated with PVDC coating material and baking and curing；Then line cools down on double coating head web coatable machines,Winding is offline, is positioned in 60 DEG C of environment and cures 40h, obtains the film substrate containing PVDC coating material；
2) antimicrobial pressure sensitive adhesive compositions are prepared：Acrylic Pressure Sensitive Adhesive is mixed with chlorohexidene anti-Microorganism pressure sensitive adhesive compositions；
Acrylic Pressure Sensitive Adhesive is polymerized by following component by weight：
It is 40 parts of acrylic acid, 30 parts of butyl acrylate, 70 parts of methyl acrylate, 20 parts of Isooctyl acrylate monomer, 4 parts of rosin, sweet10 parts of oil, 270 parts of ethyl acetate, 5 parts of initiator, 1.2 parts of isocyanate curing agent；
The specific preparation method of antimicrobial pressure sensitive adhesive compositions is as follows：
a：1 part of initiator is dissolved into 50 parts of ethyl acetate solutions, acrylic acid, the propylene of formula ratio are then sequentially addedAcid butyl ester, methyl acrylate, Isooctyl acrylate monomer, glycerine obtain mixed liquor after being thoroughly mixed uniformly；
b：50 parts of ethyl acetate are added in reactor and are warming up to 80 DEG C, 1/2 volume is slowly added dropwise after reflux is stablizedAbove-mentioned mixed liquor is stirred to react 1.5 hours at 82 DEG C；
c:Remaining initiator is dissolved in the ethyl acetate solution for forming initiator in remaining ethyl acetate, and this is drawnSend out the ethyl acetate solution reaction system for being slowly added drop-wise to step 2) synchronous with the above-mentioned remaining mixed liquor of 1/2 volume of agentIn, continue that rosin milk is added dropwise into reaction system after dripping, being kept for 82 DEG C, the reaction was continued 0.5 hour, obtains acrylatePressure-sensitive adhesive；
d：After Acrylic Pressure Sensitive Adhesive is cooled to room temperature, 3 parts of chlorhexidine gluconates are added dropwise to get to anti-micro- lifeObject pressure sensitive adhesive compositions.
e：Isocyanate curing agent is added in composition before being coated with antimicrobial pressure sensitive adhesive compositions, high speedBlender stirs 18 minutes, stands 18 minutes.
3) the antimicrobial seal laber material of patch can repeatedly be torn by preparing：By coating machine by antimicrobial pressure-sensitive adhesiveIt is coated on release substrate, baking and curing forms antimicrobial formation of pressure-sensitive adhesive layer, then contains PVDC by what step 1) obtainedOn compound to the antimicrobial formation of pressure-sensitive adhesive layer of film substrate of coating material, pass through the pressure of coating machine and the off-type force of release paperAntimicrobial formation of pressure-sensitive adhesive layer is transferred to the film substrate layer containing PVDC coating material, passes through coating machine connection cooling deviceIt is cooling, it winds, is offline, being positioned over 55 DEG C of environment curing 120h, obtain the antimicrobial seal laber material that can repeatedly tear patch.
By test, by the antimicrobial seal laber material obtained by the above method that can repeatedly tear patch, containingThe oxygen permeability of the film substrate of PVDC coating material is 3.0mL/ (m20.1MPa for 24 hours), penetrability be 4.1g/ (m2·24h)；
The glutinous base power of antimicrobial pressure sensitive adhesive compositions is 48mN/m, cohesive force is 6.1N/ inches；
The off-type force of the release substrate of siliceous oil coating is 13g/ inches；
The thickness of the priming coat is 0.5 μm；The thickness of the PVDC coating material is 3.0 μm, antimicrobial pressure sensitive adhesiveThe thickness of adhesive layer is 26 μm.
Application Example 4
By embodiment 4 it is obtained can repeatedly tear patch antimicrobial seal laber material by printing trade mark or pattern,It obtains repeatedly tearing the antimicrobial seal laber of patch after cross cutting, and the label is affixed on to the opening of high alcohol Wet paper towel packing bagPlace.
Effect and performance detection
1. the antimicrobial seal laber that can repeatedly tear patch in couple Application Example 1-4 carries out effect and performance test,The project and result of test are referring to table 1.
Table 1
2. the antimicrobial test of antimicrobial pressure sensitive adhesive seal laber and its effect
Test philosophy：Experiment bacterium solution is directly dripped on the gluing surface of label, making bacterium fully on the gluing surface of labelContact exposure certain time, culture medium is then covered, remaining thalli growth is made.Compare antimicrobial sample bacterium amount and decline percentage,Its antibacterial ability is judged.Colony Forming Unit is counted using magnifying glass.
Operation is as follows：1) prepared by bacterium solution：The fresh broth culture of Escherichia coli for 24 hours is taken, 20min is stood after shaking up, it is diluteIt is 10 to be interpreted into bacterium number5~106The bacterium solution of cfu/mL；2) microbiological contamination：The label that size is 5.0 × 5.0cm, gluing is put upwardlyIn the sterilized petri dishes for entering diameter 9cm, 1.5mL bacterium solutions are dropped evenly, so that it is uniformly distributed and is absorbed on the gluing surface of label, oftenA sample repeats 6 pieces, sets dry 1h in 37 DEG C of incubators；3) it is put down in nutrient agar by the gluing surface of the microbiological contamination label after drying is smoothPlate surface, then gluing surface with semisolid nutrient agar fat uniform fold microbiological contamination label surface, thickness is moderate, sets 37 DEG C of incubatorsInterior culture 48h；4) result is observed：It is added dropwise in dyeing 1h on above-mentioned semisolid nutrient agar fat, using magnifying glass with husky of common dye dyeing liquorThe clump count on the gluing surface of every label is counted, the clump count average value of 6 pieces of samples is calculated and is recorded；5) it compares：In experimentIf the pressure sensitive adhesive product control sample of homogeneity non-antimicrobial agent performance；6) antibacterial bacteriostatic rate is calculated：Above-mentioned experiment in triplicate, takesAverage value calculates antimicrobial and bacteriostasis rate using following manner：
Antimicrobial and bacteriostasis rate=[(A-B)/A] × 100%
In formula：A is to compare common pressure sensitive adhesive product average colony number；B is average bacterium on the gluing surface of antimicrobial labelFall number.
Antimicrobial experimental result and its analysis
The 10 groups of antimicrobial seal labers (1-10) of the present invention tested respectively with above-mentioned Quine's method resist micro-Biology and bacteriostasis the result is shown in Figure 1；Meanwhile the 10 groups of antimicrobial seal laber (1-10 of the present invention tested respectivelyExample), antimicrobial and bacteriostasis repeats to test in three times, and result is embodied in Fig. 1 together.
Quine's method is directly dripped bacterium solution on the label of antimicrobial compositions of the present invention, is covered to cultivateBase reinforces microorganism with the contact of antimicrobial label to show its anti-bacteriostasis, and experimental result is according to anti-bacteriostasis rate sizeJudge；The test of present invention confrontation bacteriostasis additionally uses dyeing liquor and is dyed to bacterium colony, and test effect is made to be easier to seeIt examines, method is feasible, as a result accurately and reliably.It is real that dyeing is carried out through the bacterium colony under double of the solid agar medium covering of husky of common dye dyeing liquorIt tests, the bacterium colony after dyeing takes on a red color, and bacterium colony is clear, is easy to observe, improves test accuracy and reliability.The present invention distinguishesThe antimicrobial seal laber sample that can repeatedly tear patch containing chlorohexidene (1-5%) of 10 groups of different contents is tested, is resistedMicroorganism and fungistatic effect all reach the desired effect of the present invention in various degree.Further to verify its repeatability, so adoptingIt is tested with 3 repetitions, 10 groups of antimicrobial compositions have antibacterial bacteriostatic effect to Escherichia coli etc..
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present inventionClaimed range.