Summary of the invention
For solving above-mentioned technical problem, the invention provides a kind of at the stream for patient is administeredIn body infusion apparatus use flow regulator, with described flow regulator infusion apparatus andManufacture method, is configured to the flow of the segment fluid flow passage in multiple fluid passages or whole fluid passageDifferent from each other, then the flow by being arranged between outlet and the outlet conduit of multiple fluid passage selectsMechanism selects the segment fluid flow passage of multiple fluid passages to connect with outlet conduit, utilizes mechanical structure to obtainObtain multiple different flow to select.
First aspect according to embodiment of the present invention, it is provided that a kind of for patient is administeredThe flow regulator used in fluid infusion device, this device comprises the steps that multiple fluid passage, is used forConveyance fluid and the segment fluid flow passage being configured to make to flow through in the plurality of fluid passage or all fluidThe flow of the fluid of passage is different from each other；Inlet duct, connects with the entrance of the plurality of fluid passage,For described fluid is delivered to the plurality of fluid passage；Outlet conduit, for by the plurality of fluidThe fluid output of conveying in passage；Flow selection mechanism, be arranged in the outlet of the plurality of fluid passage withBetween described outlet conduit and be configured to select the segment fluid flow passage in the plurality of fluid passage and instituteState outlet conduit connection.
In some embodiments, the plurality of fluid passage may be disposed in single layer of chips.Chip is permissibleBeing made up of the material of such as glass, resin or other macromolecular materials etc, the shape of chip can also beVaried, such as, rectangle, square, circular etc..And, the fluid passage on chip can be passed throughThe cutting mode such as (such as, cut etc.) or etching makes, and such as, is cut into the opening of groove-likeFormula passage.Certainly, fluid passage can also is that the enclosed channel embedding chip.The width of fluid passageOr the degree of depth can be in the scope of 5 μm to 100 μm.Multiple fluid passages can be with various different on chipMode is arranged, and such as, the orthoscopic that multiple passages can be parallel on chip is arranged, multiple passagesCan also arrange in chip upper curve formula or coiling, be that concentric discs is around cloth with the center of chip for the center of circlePut, arrange radially along radial direction for the center of circle with the center of chip, it is also possible to the center of chip withOuter is some center of circle layout etc. radially.According to fluid passage arrangement on chip, canCorrespondingly to arrange entrance and exit position and the passage length etc. of multiple fluid passage.
In some embodiments, described flow selection mechanism comprises the steps that channel connection parts, describedIn single layer of chips and be positioned on the outlet of the plurality of fluid passage, having can be by the plurality of fluidMultiple selector channels that the outlet of passage connects with described outlet conduit respectively；Channel switching parts, with instituteState channel connection parts to engage, and be configured to selectively turn on or close described selector channel.
In some embodiments, the plurality of selector channel can be disposed on described channel connection partsOn multiple through holes, such as, the quantity of through hole can be equal with the quantity of selector channel.
In some embodiments, described channel switching parts comprise the steps that diaphragm seal, are covered in described logicalOn multiple through holes of road communication means；Multiple select buttons are corresponding with the plurality of through hole and be positioned at instituteState on diaphragm seal, each in the plurality of select button have with on described channel connection partsThe protuberance of through hole coupling, and described protuberance is configured to engage with described through hole and leads to described to closeThe connection of fluid passage corresponding to hole and described outlet conduit or can from the release of described through hole or depart fromOpen the connection of the fluid passage corresponding with described through hole and described outlet conduit.
In some embodiments, described channel switching parts comprise the steps that diaphragm seal, are covered in described logicalOn the through hole of road communication means；Select slide block, be positioned on described diaphragm seal, have and described passageThe protuberance of the through hole coupling in communication means, wherein, described selection slide block is configured to be pressed in described diaphragm sealUpper slip is so that described protuberance can engage to close the fluid passage corresponding with described through hole with described through holeConnection with described outlet conduit or can be from the release of described through hole or depart to open and described through hole pairThe fluid passage answered and the connection of described outlet conduit.
In some embodiments, the quantity of the protuberance of described selection slide block can be less than described fluid passageQuantity.
In some embodiments, the plurality of fluid passage can be configured to outlet and is positioned at described single layer of chipsCircular surface circumference on.
In some embodiments, described flow selection mechanism comprises the steps that selection dish, covers described monolayerThe plurality of fluid passage on chip, has round-shaped, at the circle on a surface of circle selection dishHave on week respectively with multiple through holes of the outlet of the plurality of fluid passage, diaphragm seal, be covered inOn described selection dish, select knob, be positioned on described diaphragm seal, have corresponding with described selection dishRound-shaped, the circumference that circle selects knob has the protuberance mated with described through hole, described outletPipeline runs through described diaphragm seal by described selection knob and the vented liquid with described selection dish connects, itsDescribed in select knob to be configured to rotate so that described protuberance is pressed into described logical together with described diaphragm sealThe fluid communication of hole outlet with described outlet conduit to close the fluid passage corresponding with described through hole, itsDescribed in the quantity of protuberance less than the quantity of described traffic channel.
In some embodiments, described selection knob can have storage described diaphragm seal, described selection dishRecess with described chip.
In some embodiments, the plurality of fluid passage can be respectively arranged on multilayer chiop, such as,Can arrange a fluid passage on one layer of chip, fluid passage can be with various different on chipMode is arranged.
In some embodiments, described multilayer chiop can be coated with on layer chip stacked together and eachBarrier film.
In some embodiments, described inlet duct can run through in one end of the multilayer chiop of described stackingDescribed multilayer chiop connects with the entrance with the plurality of fluid passage with described barrier film.
In some embodiments, described flow selection mechanism comprises the steps that hollow penetrating member, described inThe cardinal extremity of empty penetrating member connects with described outlet conduit, and the sidewall of front end has opening；Select slide block,Fix with the cardinal extremity of described hollow penetrating member, be configured to be slided so that described hollow penetrating memberFront-end selectivity pierce through the barrier film on described multilayer chiop so that described opening and the plurality of fluid lead toA fluid passage connection in road.
In some embodiments, described hollow penetrating member can form as one with described outlet conduit,Such as, the hollow penetrating member on the sidewall of front end with opening can either serve as outlet conduit, also canEnough parts as flow selection mechanism.
In some embodiments, described chip is arranged the opposite side of fluid passage can have bellmouth,Described inlet duct carries to the plurality of fluid passage with the state being stuck in described bellmouth through flexible ballFluid.
In some embodiments, in the plurality of fluid passage, the flow of fluid can be by the length of fluid passageOne or more in degree, shape of cross section or cross-sectional area determines.
In some embodiments, the plurality of fluid passage can be formed on chip by cutting or etching.
In some embodiments, described fluid can include insulin.
Second aspect according to embodiment of the present invention, it is provided that a kind of being used for flow regulatorThe fluid infusion device being administered patient, this equipment comprises the steps that (such as, housing may be adapted to housingIt is worn on patient skin so that patient's portable use, or can be worn on belt, be placed in pocket)；Reservoir, is positioned at described housing, for storing the fluid of infusion；Conveying assembly, is positioned at described housingIn and connect with described reservoir fluid, the fluid in described reservoir is delivered to injecting assembly；Injecting assembly, is positioned at described housing and connects with described conveying assembly, for by described conveying assemblyThe fluid of output connects with described Patient Fluid via the entry needle extended from described housing；Wherein, instituteState conveying assembly and include flow regulator recited above, the inlet duct of described flow regulator withDescribed reservoir connects, and described outlet conduit connects with described injecting assembly.
The third aspect according to embodiment of the present invention, it is provided that a kind of for manufacturing for patient is enteredThe method of the flow regulator used in the fluid infusion device that row is administered, the method comprises the steps that offerFor multiple fluid passages of conveyance fluid, wherein, the plurality of fluid passage is configured to make to flow through describedSegment fluid flow passage or the flow of the fluid of whole fluid passage in multiple fluid passages are different from each other；CarryFor the inlet duct for described fluid being delivered to the plurality of fluid passage, wherein, described inlet tubeRoad connects with the entrance of the plurality of fluid passage；There is provided for by conveying in the plurality of fluid passageThe outlet conduit of fluid output；Arrange between outlet and described outlet conduit in the plurality of fluid passageFlow selection mechanism, wherein, described flow selection mechanism is configured to select in the plurality of fluid passageSegment fluid flow passage connects with described outlet conduit.
Fourth aspect according to embodiment of the present invention, it is provided that a kind of for manufacturing with Flow-rate adjustment dressThe method of the fluid infusion device for patient is administered put, the method comprises the steps that offer housing,Providing a store for the reservoir of the fluid of infusion, wherein, described reservoir is positioned at described housing；CarryThe infusion assembly of injecting assembly, wherein, described conveying group it is delivered to for the fluid in described reservoirPart is positioned at described housing and connects with described reservoir fluid；There is provided for by defeated for described conveying assemblyThe injecting assembly that the fluid gone out connects with described Patient Fluid via the entry needle extended from described housing,Wherein, described injecting assembly is positioned at described housing；Wherein, described conveying assembly includes above-mentioned flowAdjusting means, the inlet duct of described flow regulator connects with described reservoir, described outlet conduitConnect with described injecting assembly.
Said apparatus, equipment and the method that embodiment of the present invention provides, by by multiple fluid passagesPart or all of fluid passage in the flow of fluid be configured to different from each other and utilize flow selection mechanismA part of fluid passage therein is selected to connect with outlet conduit, it is possible to obtain multiple different flow and select.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing to thisBright it is described in further detail.It should be noted that the present invention is not limited to parts structure shown in the drawingsMake and/or arrange, without departing from the case in the spirit of the invention, it is also possible to the various embodiment party to the present inventionFormula carries out various different combination.
Seeing Fig. 1, Fig. 1 is defeated at the fluid for being administered patient according to embodiment of the present inventionThe conceptual schematic view of the flow regulator used in note equipment.Flow regulator 1 comprises the steps that multipleInlet duct 12 (such as, the thorn of hollow that fluid passage 11 connects with the entrance of the plurality of fluid passageWear parts etc.), by multiple fluid passages fluid export outlet conduit 13 (such as, the thorn of hollowWear parts etc.) and the flow choosing that is arranged between outlet and the outlet conduit 13 of multiple fluid passage 11Select a good opportunity structure 14.Wherein, fluid can include the fluid media (medium) of such as insulin, analgesics etc, and flow isFlowing through the Fluid Volume of the cross section of fluid passage in unit interval, Fluid Volume can calculate with volume.When infusion fluid is insulin, the unit of flow can be unit/hour (unit/hour), wherein,Unit/hour in unit and the substitution ratio of milliliter be 100:1, say, that 1 milliliter is 100 units.Multiple fluid lines 11 entrance receive inlet duct 12 conveying fluid and fluid in each fluid passageMiddle circulation, and be configured to make to flow through the segment fluid flow passage of the plurality of fluid passage or all fluid lead toThe flow in road is different from each other.For example, it is possible to by multiple (such as, more than or equal to 2) fluid passageFlow be configured to all differ, or can by the part in multiple fluid passages (such as, wherein2,3,4 or more) be configured to different from each other.Flow selection mechanism 14 is arranged on manyBetween outlet and the outlet conduit 13 of individual fluid passage 11, its entrance goes out with multiple fluid passage 11Mouth fluid communication, outlet is in fluid communication with outlet conduit 13, is configurable to select multiple fluid passageSegment fluid flow passage (fluid passage that such as, 1,2,3 or more flow differ) withOutlet conduit is in fluid communication, thus obtains multiple different flow and select.
[the first embodiment]
Fig. 2 is setting at the fluid infusion for being administered patient according to first embodiment of the inventionThe structural representation of the flow regulator of standby middle use；Fig. 3 be shown in Fig. 2 for patient is enteredThe decomposition view of the flow regulator used in the fluid infusion device that row is administered.Flow regulator 100Fluid passage 101, inlet duct 102, outlet conduit 103, channel connection parts 104, close can be includedSealer 105 and select button 106.Wherein, multiple fluid passages 101 are to be arranged in rectangle in parallelSingle layer of chips 107 on, have embed chip groove-like structure, top be coated with cover plate 108 with will streamBody passage 101 is closed with extraneous.Such as, chip 107 can be by such as glass, resin or other high scoresThe material of sub-material etc is made, fluid passage 201 can by cutting (such as, cut) orEtching mode is formed on chip 107.Multiple fluid passages 101 on chip 107 except usingOutside above-mentioned parallel form is arranged, it is also possible to use the form wriggled to arrange.Embodiments of the present inventionMultiple fluid passages arrangement form on chip is not defined.Fluid in each fluid passage 101Flow can by the one in the length of fluid passage, cross-sectional area or shape of cross section, the two orThree determines.Inlet duct 102 can pass through the through hole 1081 on cover plate 108 at fluid channel inlet endThe common fluid communication of multiple fluid passages 101 with on chip 107.
Channel connection parts 104 are bearing on chip 107 and are positioned on the outlet of fluid passage 101,Such as, it is mountable to cover on the cover plate 108 of fluid passage 101, cover plate 108 has and fluidThe through hole 1082 of the positions and dimensions coupling that passage 101 respectively exports, channel connection parts 104 are via through hole1082 connect with fluid passage 101.Channel connection parts 104 have going out fluid passage 101 respectivelyMultiple through holes 1041 that mouth connects with outlet conduit 103, such as, the quantity of through hole 1041 and fluid passageThe quantity of 101 is equal.Through hole 1041 can select the cylindricality through hole of upper and lower surface equal diameters,Can also select the through hole in that side of contact diaphragm seal 105 with bowl-like depression, such shape setsCount and can strengthen sealing property further when select button closes through hole.Channel connection parts 104 also can setPutting the recess 1042 all connected with multiple through holes 1041, outlet conduit 103 can pass through flexible block 109 (exampleAs, silica gel block) insert recess 1042, thus connect with through hole 1041 fluid on channel connection parts 104Logical.
Diaphragm seal 105 (such as, pellosil) is covered on the through hole 1041 of channel connection parts 104,The sealing closed can be strengthened when the through hole 1041 of select button 106 closing passage communication means 104.Multiple select buttons 106 be arranged on diaphragm seal 105 and with the through hole 1041 of channel connection parts 104Correspondence in quantity and position.Each button in multiple select buttons 106 can have and channel connection portionThe protuberance 1061 (such as, salient point) of through hole 1041 coupling of part 104, such as, size or vpg connectionCoupling.Such as, user and/or patient can press a select button 106 with by the protuberance 1031 of this buttonIt is pressed into through hole 1041 corresponding with this protuberance on channel connection parts 104 together with diaphragm seal 105, fromAnd close the fluid passage 101 of this through hole 1041 correspondence and the fluid communication of outlet conduit 103.Such as,User can also lift a button in multiple select button 106 with by the protuberance 1061 of this button from thisThe through hole 1041 that protuberance is corresponding discharges or makes protuberance 1061 depart from from the through hole 1041 that this protuberance is corresponding,Thus the fluid passage 101 of this through hole 1041 correspondence is turned on outlet conduit 103.It is to say, useFamily is by selecting the different select button of pressing can obtain multiple different flow, and flow selects operation letterSingle, quick, it is simple to user uses under several scenes (such as, outdoor activity scene etc.).
The flow summation that flow is multiple fluid passages on X and chip in the fluid passage closed is YWhen, the button corresponding by this fluid passage on pressing select button carrys out closing passage communication meansThe through hole that this fluid passage upper is corresponding, can obtain the flow of (Y-X) at outlet conduit.Due on chipThe flow of multiple fluid passages is different from each other, say, that the value of X is variable, then logicalCross and select different buttons (fluid passages that corresponding closedown is different) can obtain different at select buttonFlow.By select button open a fluid passage connect with outlet conduit when, can obtainThe flow that flow is this fluid passage opened.
Flow for fluid passage a part of in multiple fluid passages is different from each other, and remainder fluid leads toThe situation that road flow is identical, that portion that on channel connection parts, the quantity of through hole can be different from each other with flowThe quantity of shunting body passage is identical, corresponding select button may select the passage closed or open be flow thatThese those different fluid passages.
[deformation of the first embodiment]
Mode except selecting diaphragm seal to coordinate with multiple select buttons realizes through hole on channel connection partsSwitch, it is also possible to use diaphragm seal with selection slide block mode realize.For diaphragm seal and selection slide blockEmbodiment, diaphragm seal is covered on the through hole of channel connection parts, select slide block be positioned at diaphragm sealOn, there is the protuberance mated with the through hole on channel connection parts, and can be configured to be pressed in sealingSlide on film so that protuberance is pressed into the through hole on channel connection parts together with diaphragm seal, thus close this and lead toThe fluid communication of fluid passage corresponding to hole and outlet conduit, it is also possible to be configured to protuberance from channel connectionRelease in through hole on parts is so that fluid passage corresponding to this through hole connects with outlet conduit.
Select slide block can have one or more protuberance (such as, salient point) on the surface of contact diaphragm seal,Can be slided selection slide block by user and/or patient by the way of sliding shoe or sliding bar, so that thereonProtuberance is pressed into different through holes together with diaphragm seal, and selectivity is closed fluid corresponding to different through holes and led toRoad and the fluid communication of outlet conduit, or, or remove to open and this through hole from through hole release by protuberanceCorresponding fluid passage and the connection of outlet conduit.
When being connected with unlatching from through hole release by protuberance, selectable flow is openedOr the flow sum of passage corresponding to multiple through hole.For protuberance being pressed into the through hole situation with closedown connection,When on selection slide block, the quantity of salient point is 1, obtainable flow is chosen as multiple fluid passages on chipFlow summation deduct the flow of 1 fluid passage selecting to close.Selecting the quantity of salient point on slide block is 2Time, obtainable flow is chosen as the flow summation of multiple fluid passages on chip and deducts select to close 2The flow of individual fluid passage.When the salient point of selection slide block is other quantity, by that analogy.Preferably, choosingSelect the quantity quantity less than fluid passage of slide block upper convex portion, such as, few 1.At other embodimentsIn, select fewer than the quantity of fluid passage 2 of the quantity of slide block upper convex portion, or 3, etc..
Fig. 4 is the schematic diagram of the fluid passage according to one embodiment of the present invention.Fig. 5 a to Fig. 5 c is rootThe slip schematic diagram selecting slide block according to one embodiment of the present invention.As shown in Figure 4, with insulinAs a example by conveying, 3 fluid passages 401,402 and 403, the flow of the fluid flow through inside them is respectivelyIt is 40 units/sky, 20 units/sky, 20 units/sky.Shown in as shown in Figure 5 a to 5 c, select the convex of slide blockPoint is 2, fewer than the quantity of fluid passage 1, selects slide block when shown in Fig. 5 a, selectsSlide block closes the through hole on the channel connection parts of passage 401 and 402 correspondence, passage 403 and outletPipeline communication, obtainable flow is 20 units/sky；Slide block is selected to slide down to figure along the direction of diagramState shown in 5b, selects slide block to close leading on the channel connection parts of passage 402 and 403 correspondenceHole, passage 401 connects with outlet conduit, and obtainable flow is 40 units/sky；Select slide block along diagramDirection slide down to the state shown in Fig. 5 c, select slide block to close the passage of passage 403 correspondence evenThrough hole on logical parts, passage 401 connects with outlet conduit with 402, and obtainable flow is (40+20)Unit/sky.
[the second embodiment]
In the embodiment shown in Fig. 2 and Fig. 3, chip has the surface of rectangle, multiple fluid passageIn the square surface of chip, orthoscopic is arranged in parallel, and chip can also have various difform surface(such as, circular etc.) and fluid passage can also use diversified layout (such as, spiral,Radial radiation layout etc.).
Fig. 6 a is setting at the fluid infusion for being administered patient according to second embodiment of the inventionThe structural representation of the flow regulator of standby middle use；Fig. 6 b be shown in Fig. 6 a for patientThe flow regulator used in the fluid infusion device being administered is along the diametric sectional view of A-A '；Fig. 7 is the Flow-rate adjustment used in the fluid infusion device for being administered patient shown in Fig. 6 aThe decomposition view of device；Fig. 8 is the layout schematic diagram of the fluid passage according to second embodiment of the invention；Fig. 9 a is the structural representation of the selection dish according to second embodiment of the invention；Fig. 9 b is shown in Fig. 9 aSelection dish along the diametric sectional view of B-B '；Figure 10 is the selection according to second embodiment of the inventionThe upward view of knob.
As shown in Fig. 6 to Figure 10, flow regulator 200 can include fluid passage 201, inlet duct202, outlet conduit 203, selection dish 204, diaphragm seal 205, selection knob 206.Fig. 8 shows streamThe arrangement of body passage, multiple fluid passages 201 on the chip 207 have circular surface with circleThe center of circle on surface is that concentric circles is arranged, the common entrance in multiple fluid passages 201 is arranged on circular surfaceThe center of circle, four outlets are respectively provided with circumferentially, spaced 90 degree.Can be according to fluid passage dishAround length or channel cross-sectional area limit inner fluid passage flow.Fluid passage on chip except useOutside mode shown in Fig. 8 is arranged, it is also possible to adopt layout in other ways, such as, fluid passage is commonSame entrance may be disposed at the position in the deviation circular surface center of circle, and each outlet is arranged on circumference, along this positionPut curvilinear layout fluid passage (such as, shown in Figure 14), or along the center of circle to each outlet radial direction inRadial layout fluid passage (such as, as shown in figure 15).
On chip 207, the opposite side of layout fluid passage 201 (is core from the point of view of the direction shown in Fig. 6 bThe lower section of sheet 207) bellmouth 2071, inlet duct 202 (such as, the penetrating member of hollow) can be setCan be stuck in bellmouth 2071 through flexible ball 208 (such as, silica-gel sphere), insert fluid passage 201Common entrance, to multiple fluid passages 201 conveyance fluid.By flexible ball 208 and bellmouth 2071Laminating can strengthen sealing.
Selection dish 204 has corresponding with circular chip 207 round-shaped, covers circular chip 207Multiple fluid passages 201.The circumference of selection dish 204 circular surface has and is arranged on circular chip 207 circleMultiple through holes 2041 of the outlet of each fluid passage 201 on week.As shown in figures 9 a and 9b,Through hole 2041 can be the through hole at upper surface with bowl-like depression.In other embodiments, through hole canTo be the cylindrical hole of upper and lower surface equal diameters.
It is coated with diaphragm seal 205 on selection dish 204, is to select knob 206 on diaphragm seal 205.ChoosingSelect knob 206 and there is the circular surface corresponding with selection dish 204, the circumference of this circular surface has withThe protuberance 2061 of through hole 2041 coupling of selection dish 204, such as, positions and dimensions is designed to blockThe salient point of the through hole shown in Fig. 9 a and Fig. 9 b.The home position selecting the circular surface of knob 206 also hasThere are the through hole 2062 allowing outlet conduit 203 (such as, the penetrating member of hollow) to pass in and out, outlet conduit203 can run through diaphragm seal 205 via through hole 2062, with through hole 2041 fluid on selection dish 204 evenLogical.Such as, outlet conduit 203 can be inserted into the circle centre position being positioned at selection dish 204 and each with on circumferenceThrough hole 2041 all connects the recess 2042 of (such as, can be connected) by the mode such as groove or pipeline, thusMake the fluid passage connection that outlet conduit 203 is corresponding with through hole 2041 on selection dish 204.
Select position and through hole 2041 position circumferentially on selection dish 204 of the protuberance 25 of knob 206Put correspondence and size can blocking via hole 2041.Knob 206 is selected to be configured to be rotated to drive itOn protuberance 2061 circumferentially move, select protuberance 2061 together with close by the radian that circumferentially rotatesSealer 205 is pressed into the one or more through holes 22 on selection dish 204 together, thus it is right to close through hole 2041The outlet of the fluid passage answered and the fluid communication of outlet conduit 203.Wherein, knob 206 epirelief is selectedThe number (such as, the protuberance number shown in Fig. 9 is 3) in portion 2061 can be less than the number of fluid passage(such as, the fluid passage number shown in Fig. 8 is 4).It that case, can obtain at outlet conduitFlow corresponding to fluid passage that flow is connection.By knob will be selected to rotate different radian, optionalSelect the through hole that the fluid passage being intended to close is corresponding on selection dish, thus obtain different flows and select.
In the flow regulator 200 shown in Fig. 6 b, select knob 206 to have and can receive diaphragm seal205, the recess 2063 of selection dish 204 and chip 207.The basal surface of recess 2063 is and selection dish 204The circular surface corresponding with chip 207 size, at the protuberance provided circumferentially about 2061 of this circular surface.ChoosingThe recess arrangement selecting knob 206 can reduce the overall dimensions of flow regulator, allows whole device more step upGather, also allow for device miniaturization.But, in other embodiments, selection knob may be designed as not to be hadThere are storage diaphragm seal, selection dish or a recess of chip, but are directly mounted at the profile on diaphragm seal and areCylindrical knob.
[the 3rd embodiment]
As it was previously stated, multiple fluid passages may be disposed in single layer of chips, it is possible to be arranged at multilayer laminatedOn chip.Such as, multiple fluid passages can be respectively arranged on multilayer chiop, can set on one layer of chipPutting a fluid passage, the fluid passage on every layer of chip can be to passage length, cross-sectional area or transversalOne in the shape of face, the two or three are configured.Additionally, fluid passage can be to cut on chipCut or etch the groove of formation, it is also possible to be the tube shaped embedding chip.For the passage of form of grooves,Multilayer chiop can cover barrier film (such as, pellosil etc.) on chip stacked together and each, thusBlock the fluid in passage to flow out.Inlet duct can the multilayer chiop of stacking one end (such as, with enterOne end that mouthful pipeline is corresponding) run through the barrier film on multilayer chiop and chip, thus with on each layer chipThe entrance connection of each fluid passage.
Figure 11 is setting at the fluid infusion for being administered patient according to third embodiment of the inventionThe structural representation of the flow regulator of standby middle use；Figure 12 be shown in Figure 11 for patientThe decomposition view of the flow regulator used in the fluid infusion device being administered；Figure 13 is Figure 11The section view of the shown flow regulator used in the fluid infusion device for patient is administeredFigure.Flow regulator 300 shown in Figure 11 can include multiple fluid passage 301 (being illustrated as 3),Inlet duct 302 (such as, the penetrating member of hollow), outlet conduit 303 and selection slide block 304.3Individual fluid circulation 301 is separately positioned on 3 layers of chip 305, and these 3 layers of chips can form a chipset.Fluid passage 301 is form of grooves passage at chip 305, is also covered with barrier film 306 on chip 305,For example, it may be pellosil etc., the fluid in block fluid passage 301 is flowed out by chip 305.EnterMouth pipeline 302 can run through each layer chip 305 and barrier film thereon at the arrival end of fluid passage 301306, to fluid passage conveyance fluid.For example, it is possible on barrier film 306 with the entrance of fluid passage 301Corresponding position arranges the hole more slightly larger than the entrance hole diameter of fluid passage 301, and fluid can via this some holes certainlyBy the fluid passage flowing into each layer.Cover plate 307 can also be covered on the superiors' barrier film 306 of chipset,Cover plate 307 has through hole 3071, exit passageway 303 in the outlet side of the fluid passage 301 of chipsetChipset can be inserted via the through hole 3071 on cover plate 307, thus flow with each fluid passage of chipsetBody connects.
Can have opening on the sidewall of outlet conduit 303 (such as, the penetrating member of hollow) front end, selectSlide block 304 can be fixed with the cardinal extremity of outlet conduit 303, and be configured to be slided so thatThe front-end selectivity of outlet conduit 303 pierces through the barrier film 306 on multilayer chiop, so that outlet conduit 303The opening of front end connects with a fluid passage in multiple fluid passages.Fluid passage due to each layerFlow is different, and the selection slide block 304 that slides controls outlet conduit 303 and pierces through the chipset of stacking, makes front endOpening connect with the fluid passage in chipset one layer of chip, can obtain this layer of chip fluid lead toThe flow that road is corresponding.Such as, in the embodiment shown in Figure 13, outlet conduit 303 inserts chipsetThe fluid passage of the superiors, then the flow that the fluid passage of the superiors' chip is corresponding can be obtained.
In the above-described embodiment, selecting slide block is to coordinate with outlet conduit to realize flow selection.At otherIn some embodiments, it is also possible to realize flow by selecting slide block and single hollow penetrating member to coordinateSelecting, in such embodiment, outlet conduit can be to be not designed to the penetrating member form of hollow.The cardinal extremity of hollow penetrating member (such as, the pin of hollow) can connect with outlet conduit, the sidewall of front endOn be designed with opening.Hollow can be made by the selection slide block that the cardinal extremity slided with hollow penetrating member is fixedThe penetrating member front end outlet side selectivity in fluid passage pierces through the barrier film of multilayer chiop, so that frontOpening on the wall of side and the outlet of the fluid passage of one layer of chip in multilayer chiop, it is thus achieved that this fluidThe flow that passage is corresponding.
Embodiment of the present invention additionally provide a kind of with flow regulator for patient is administeredFluid infusion device, this fluid infusion device can include housing, and such as, housing may be adapted to be worn on troublePerson's skin is so that patient's portable use, or can be worn on belt, be placed in pocket；It is positioned at housingIn and for storing the reservoir of fluid of infusion；It is positioned at housing and the fluid with reservoir connectsLogical conveying assembly, conveying assembly is for being delivered to injecting assembly by the fluid in reservoir；It is positioned at housingIn and with conveying assembly fluid communication injecting assembly, for by conveying assembly export fluid via fromThe entry needle that housing extends connects with Patient Fluid.Wherein, infusion assembly can include having the mostPlanting the flow regulator that embodiment describes, wherein, the inlet duct of flow regulator can be with storageLiquid device connects, and outlet conduit is in fluid communication with injecting assembly.Figure 16 is the band according to embodiment of the present inventionThere is the schematic diagram of the fluid infusion device for patient is administered of flow regulator.Fluid infusionEquipment 400 can include that select button 402 that shell 401, opening from shell 401 extend is (such as,Can be the select button 106 in flow regulator 100).Reservoir, defeated can be received in housing 401Sending component and injecting assembly etc., wherein, the surface of housing 401 can have transparent form 403, and it is permissibleAllow user to check the memory state of fluid in reservoir through shell 401, facilitate user to understand storage in timeThe conveying condition of fluid in liquid device；Conveying assembly can include for the assembly of basic crack injection with for pillThe assembly of amount injection, correspondingly, can arrange at housing 401 and control the injection button 404 that bolus quantities is injectedWith SR 405；Injecting assembly can include the entry needle that can connect with Patient Fluid, and this entry needle canControl by being arranged at the entry needle firing button 406 of housing 401.Additionally, housing 401 also can be arrangedStart pin 407, for controlling the startup of fluid infusion device 400.The fluid that embodiment of the present invention providesInfusion apparatus has flow and selects function, can pass through select button, selects slide block or select the machineries such as knobMode selects different flow quickly and easily.When infusion fluid is insulin, can facilitateUser and/or patient according to one day different periods or difference catering structure every day quickly to infusion of insulinFlow selects.And, the above-mentioned flow infusion apparatus of the present invention can by mechanical mechanism be onlyVarious flow rate selection can be carried out, compared with electronic type infusion apparatus power-actuated with needs, it is possible to significantly dropThe manufacturing cost of low infusion apparatus.
Embodiment of the present invention additionally provides a kind of defeated at the fluid for being administered patient for manufacturingThe method of the flow regulator used in note equipment.Figure 17 is the use according to one embodiment of the present inventionIn the method manufacturing the flow regulator used in the fluid infusion device for patient is administeredSchematic diagram, the method comprises the steps that step S101, it is provided that for multiple fluid passages of conveyance fluid, itsIn, segment fluid flow passage that these fluid passages can be configured to make to flow through in these fluid passages or all flowThe flow of the fluid of body passage is different from each other；Step S102, it is provided that be used for delivering the fluid to multiple fluidThe inlet duct of passage, wherein, inlet duct connects with the entrance of multiple fluid passages；Step S103,There is provided for the outlet conduit by the fluid output of conveying in multiple fluid passages；Step S104, multipleArranging flow selection mechanism between outlet and the outlet conduit of fluid passage, wherein, flow selection mechanism is joinedIt is set to select the segment fluid flow passage in multiple fluid passage to connect with outlet conduit.
Embodiments of the present invention additionally provide a kind of for manufacturing with the stream for being administered patientThe method of the fluid infusion device of quantity regulating device.Figure 18 be according to one embodiment of the present invention forManufacture the method signal of the fluid infusion device for patient is administered with flow regulatorFigure, the method comprises the steps that step S201, it is provided that housing, step S202, it is provided that for storing infusionThe reservoir of fluid, wherein, reservoir is positioned at housing；Step S203, it is provided that for by reservoirFluid be delivered to the infusion assembly of injecting assembly, wherein, conveying assembly is positioned at housing and and liquid storageDevice is in fluid communication；Step S204, it is provided that for the fluid that conveying assembly exports is extended via from housingThe injecting assembly that connects with Patient Fluid of entry needle, wherein, injecting assembly is positioned at housing.Wherein,Conveying assembly can include the flow regulator of above-mentioned various embodiment, wherein, flow regulatorInlet duct connects with reservoir, and outlet conduit is in fluid communication with injecting assembly.
Although it should be pointed out that, each side of said apparatus, equipment and method etc. is in a specific sequenceArrange with specific structure and be described, but this is only used for illustrating, and the present invention does not constitute restriction,Claimed theme is not limited to described order and structure is arranged.Those skilled in the art should manageSolve, without departing from essence of the present invention when, can to invention, various modification can be adapted, and can enterRow equivalent.Therefore, the theme that the present invention is claimed is not limited to disclosed above being embodied asMode, may also include all technical schemes falling into claims and the technology being equal to therewithScheme.Additionally, in the claims, except as otherwise noted, all of term should by broadest reasonablyThe meaning understands.