A kind of antimicrobial form aciclovir eye drop and preparation method thereofTechnical field
The present invention relates to eye drop technical field, particularly relate to a kind of antimicrobial form aciclovir eye drop and preparation side thereofMethod.
Background technology
Collyrium is the liquid medicine for the treatment of disease of eye, and its composition has numerous species according to the difference of effect, such as steroid, anti-Raw element, antihistaminic, beta-blocker, non-steroidal anti-inflammatory analgesic etc..Acyclovir (AZV) is sick to I, II type herpes simplexPoison (HSV) is effective, secondly also effective to varicella zoster virus (AZV), and viral and big and small to EB (Epstein-Barr)Cellular virus effect is more weak.Acyclovir is owing to AZV can be sick to I, herpes simplex virus type 2 and varicella zoster virusThymidine kinase (TK) phosphoric acid of poison coding turns to monophosphate acycloguanosine, the latter again by the catalysis of cellular enzymes formed diphosphonic acid,Triphosphoric acid acycloguanosine.Triphosphoric acid acycloguanosine is the potent inhibitor of hsv dna polymerase, and it is as viral DNAThe substrate of polymerase is combined with enzyme and mixes in viral DNA, thus terminates the synthesis of viral DNA.Aciclovir eye drop canEffectively various ocular disease to be controlled, there is good sterilization effect simultaneously.
Summary of the invention
The invention aims to solve shortcoming present in prior art, and a kind of eye drip rifampicin system proposedAgent and preparation method thereof.
To achieve these goals, present invention employs following technical scheme:
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 8-10 gram, 4-5 gram of chloromycetin, chlorineChange 0.3-0.5 gram of sodium, Macrogol 600 2-3 gram, vitamin B6 1-1.5 gram, vitamin B12 1-1.3 gram, boric acid 0.5-0.8 gram, thickening agent 0.6-0.8 gram, taurine 0.1-0.2 gram, Borax 0.5-0.7 gram, distilled water 150-170 milliliter.
Preferably, described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, addsThe distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to addHeat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering deviceAperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
A kind of antimicrobial form aciclovir eye drop that the present invention provides and preparation method thereof, by mould with chlorine by acyclovirThe mixing of element adds so that collyrium has higher antibiotic property, can eliminate multiple eye inflammation simultaneously, so thatThe purposes of collyrium is greatly improved, and solves various problems.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with specific embodiment, to thisInvention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, notFor limiting the present invention.
Embodiment 1
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 8 grams, 4 grams of chloromycetin, sodium chloride0.3 gram, Macrogol 600 2 grams, vitamin B6 1 gram, vitamin B12 1 gram, boric acid 0.5 gram, thickening agent 0.6 gram, taurine0.1-0. gram, Borax 0.5 gram, distilled water 150 milliliters.
Described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, addsThe distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to addHeat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering deviceAperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
Embodiment 2
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 9 grams, 4.5 grams of chloromycetin, chlorination0.4 gram of sodium, Macrogol 600 2.5 grams, vitamin B6 1.3 grams, vitamin B12 1.2 grams, boric acid 0.7 gram, thickening agent 0.7Gram, taurine 0.15 gram, Borax 0.6 gram, distilled water 160 milliliters.
Described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, addsThe distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to addHeat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering deviceAperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
Embodiment 3
A kind of antimicrobial form aciclovir eye drop, its raw material is as follows: acyclovir 10 grams, 5 grams of chloromycetin, sodium chloride0.5 gram, Macrogol 600 3 grams, vitamin B6 1.5 grams, vitamin B12 1.3 grams, boric acid 0.8 gram, thickening agent 0.8 gram, cattleSulfonic acid 0.2 gram, Borax 0.7 gram, distilled water 170 milliliters.
Described thickening agent is hyaluronic acid sodium.
The preparation method of a kind of antimicrobial form aciclovir eye drop, comprises the steps:
S1: be pre-mixed with chloromycetin by acyclovir, joins in reagent bottle by mixed acyclovir and chloromycetin, addsThe distillation water yield entering 1/4th carries out mix and blend, uses the mode of heating in water bath to heat, and bath temperature controls at 35-Between 45 degrees Celsius, prepare mixed solution A, solution A is placed standby；
S2: Macrogol 600, vitamin B6, vitamin B12, boric acid, thickening agent, taurine and Borax are mixed in advance,Join in test tube, in test tube, add four/two-component distilled water, mix, use heating in water bath mode to heat,Bath temperature controls between 35-45 degree Celsius, it is thus achieved that mixed solution B, solution B is placed standby；
S3: mixed homogeneously in test tube by the distilled water of sodium chloride with remaining 1/4th, uses the mode of heating in water bath to addHeat, bath temperature controls between 35-45 degree Celsius, it is thus achieved that solution C, solution C is placed standby；
S4: solution A, solution B and solution C are mixed, uses vibrations instrument to carry out vibrations mixing；
S5: the solution that S4 obtains is carried out fine straining process, the impurity in solution can effectively be removed, the filter opening of fine filtering deviceAperture is 1200 mesh；
S6: the solution after essence being considered packs in the vial, should be noted that the sterilization treatment of bottle bottleneck during subpackage.
A kind of antimicrobial form aciclovir eye drop that the present invention provides and preparation method thereof, by mould with chlorine by acyclovirThe mixing of element adds so that collyrium has higher antibiotic property, can eliminate multiple eye inflammation simultaneously, so thatThe purposes of collyrium is greatly improved, and solves various problems.
The above, the only present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto,Any those familiar with the art in the technical scope that the invention discloses, according to technical scheme andInventive concept equivalent or change in addition, all should contain within protection scope of the present invention.