A kind of novel antibacterial aerogel dressing and preparation method thereofTechnical field
The present invention relates to medical material tech field, particularly relate to a kind of novel antibacterial hydrogel and applyMaterial and preparation method thereof.
Background technology
Medical dressing is the medical material that a class covers for various wounds, wound surface temporarilyMaterial, can make wound exempt from antibacterial infect and the impact of other foeign element, play protection wound,The effect of wound surface, degreasing cotton gauze, as a kind of traditional dressing, plays at medicine and hygiene fieldsImportant function, but degreasing cotton gauze liquid absorption is big not, and easily glue with skin wound tissueEven, it is easily destroyed epithelium and the granulation tissue of new life when changing dressings, causes bleeding, wound is causedSecondary injury, making Principle of Pain, degreasing cotton gauze be replaced becomes market trend, current cityMore and more using aerogel dressing on field, aerogel dressing is the three-dimensional containing certain moistureThe swelling body of reticular polymer, has good water absorption and biocompatibility, hydrogel tableSurface tension between face and ambient water solution is low, it is possible to reduce to the absorption of protein in body fluidEffect, aerogel dressing has good moisture-vapor transmission and suitable gas percent of pass, energyClosely fit with irregular wound surface and do not stick together, reduce bacteria breed, and be easily changed,It addition, the thermal capacity of aerogel dressing itself is big, wound there is is cooling effect, wound can be alleviatedPain, at present, aerogel dressing is conducted extensive research by Chinese scholars, but stateInterior development is relatively slow, and also have greatly improved in terms of research and development of products space.
Summary of the invention
For the present situation of above-mentioned prior art, the technical problem to be solved is to provideOne can shorten wound healing time, alleviates patient pain, improves the novel anti-of local wound microenvironmentBacterium aerogel dressing and preparation method thereof.
The present invention solves the technical scheme that above-mentioned technical problem used: a kind of novel antibacterial waterGel dressing, according to mass percent, including:
Chitosan: 1-5%；
Carbomer: 0.5-5%；
Propylene glycol: 0.5-20%；
Ethyl hydroxybenzoate: 0.02-0.1%；
Triethanolamine: 0.2-0.7%；
Ketone peptide: 0.1-0.4%；
Deionized water: 70-95%.
The preparation method of a kind of novel antibacterial aerogel dressing, comprises the following steps:
A, being dissolved in deionized water by chitosan, temperature controls between 55-65 degree, fullyStirring is allowed to dissolve, and obtains first liquid；
B, carbomer is dissolved in deionized water swelling, and is sufficiently stirred for being allowed to dissolve, obtainsSecond liquid；
C, the second liquid of step (b) is slowly added in the first liquid of step (a)It is sufficiently stirred for, mixing；
D, in the liquid of step (c), it is sequentially added into propylene glycol, ethyl hydroxybenzoate, ketone peptide,And it is sufficiently stirred for mixing, add triethanolamine and PH is adjusted between 5.5-7；
After e, stirring eliminate bubble, obtain product.
Compared with prior art, it is an advantage of the current invention that: the present invention uses chitosan as killingMicrobial inoculum, can effective Antibacterial activity, and combine antiseptic and inhibiting bacteria function agent ethyl hydroxybenzoate, effectively changeKind local wound microenvironment, ethyl hydroxybenzoate is relatively strong to the fungistatic effect of fungus, and ethyl hydroxybenzoate coordinatesThe propylene glycol of low concentration, can strengthen antisepsis, and propylene glycol can absorb greatly as wetting agentAmount wound dissolution fluid also keeps wound moist, will not adhesion wound, alleviate patient pain, it addition,Ketone peptide is a kind of good consolidant, can shorten wound healing time, promotes that wound is more preferableHealing, reduces cicatrix, and this product adjusts the order of material mixing during configuration and strictly controlsThe temperature of prepared material so that product safety is stable.
Detailed description of the invention
Below by embodiment, the present invention is described in further detail, and following example are rightThe explanation of the present invention and the invention is not limited in following example.
A kind of novel antibacterial aerogel dressing, according to mass percent, including:
Chitosan: 1-5%；
Carbomer: 0.5-5%；
Propylene glycol: 0.5-20%；
Ethyl hydroxybenzoate: 0.02-0.1%；
Triethanolamine: 0.2-0.7%；
Ketone peptide: 0.1-0.4%；
Deionized water: 70-95%.
Wherein, chitosan is antibacterial, can be with Antibacterial activity, and chitosan also has fastThe function of short stopping blood, carbomer is high molecular weight water soluble polymer, good stability, has thickening to hangFloating grade acts on, and ethyl hydroxybenzoate is as antiseptic and inhibiting bacteria function agent, relatively strong to the inhibition of fungus, andAnd ethyl hydroxybenzoate coordinates the propylene glycol of low concentration, antisepsis is higher, and propylene glycol is as moisturizingAgent can absorb a large amount of wound dissolution fluid and keep wound moist, will not adhesion wound, alleviate troublePerson's pain, ketone peptide is a kind of good consolidant, can shorten wound healing time, promotes woundMouthful preferably healing, reduces cicatrix, triethanolamine as nertralizer, by with the carboxylic such as carbomerBase neutralizes, and forms stable macromolecular structure, reaches the application effect of thickening and moisturizing.
The preparation method of a kind of novel antibacterial aerogel dressing, comprises the following steps:
A, being dissolved in deionized water by chitosan, temperature controls between 55-65 degree, fullyStirring is allowed to dissolve, and obtains first liquid；
B, carbomer is dissolved in deionized water swelling, and is sufficiently stirred for being allowed to dissolve, obtainsSecond liquid；
C, the second liquid of step (b) is slowly added in the first liquid of step (a)It is sufficiently stirred for, mixing；
D, in the liquid of step (c), it is sequentially added into propylene glycol, ethyl hydroxybenzoate, ketone peptide,And it is sufficiently stirred for mixing, add triethanolamine and PH is adjusted between 5.5-7；
After e, stirring eliminate bubble, obtain product.
The present invention use chitosan as antibacterial, can effective Antibacterial activity, and combine anti-Rotten antibacterial ethyl hydroxybenzoate, is effectively improved local wound microenvironment, and fungus is pressed down by ethyl hydroxybenzoateBacterium effect is relatively strong, and ethyl hydroxybenzoate coordinates the propylene glycol of low concentration, can strengthen antisepsis,Propylene glycol can absorb a large amount of wound dissolution fluid as wetting agent and keep wound moist, will not glueEven wound, alleviates patient pain, it addition, ketone peptide is a kind of good consolidant, can shortenWound healing time, promotes that wound preferably heals, reduces cicatrix, this product is in configuration processThe order of middle adjustment material mixing the temperature of strict control of material so that product safety are stable.
Last it is noted that above example is only in order to illustrate technical scheme, andNon-to its restriction；Although the present invention being described in detail with reference to previous embodiment, abilityTerritory it will be appreciated by the skilled person that it still can be to the technical side described in foregoing embodimentsCase is modified, or replaces wherein portion of techniques feature on an equal basis；And these amendment orPerson replaces, and does not make the essence of appropriate technical solution depart from various embodiments of the present invention technical schemeSpirit and scope.