技术领域technical field
本发明涉及一种壳体，尤其涉及一种胶囊状壳体、胶囊状壳体的制备方法及具有该胶囊状壳体的胶囊内窥镜。The invention relates to a casing, in particular to a capsule-shaped casing, a preparation method for the capsule-shaped casing and a capsule endoscope with the capsule-shaped casing.
背景技术Background technique
随着大规模集成电路技术、MEMS、无线通信、光学技术的发展，胶囊内窥镜作为一种有效的诊断肠道疾病的方法，目前已被广泛的研究并得到了迅速的发展。胶囊内窥镜一般包括胶囊状壳体、照明装置、摄像装置、射频发射装置、电池，受检者将胶囊内镜吞咽下后，通过放置在透明前端的摄像装置拍下的图片无线传送到体外的接收器，检查人员通过接收到的图片对受试者的病情进行合理判断。与插入式的消化道内镜相比，胶囊内窥镜最大的优点是无痛、无创、安全、便捷，尤其是对小肠的检查具有独到之处。With the development of large-scale integrated circuit technology, MEMS, wireless communication, and optical technology, capsule endoscopy, as an effective method for diagnosing intestinal diseases, has been widely studied and developed rapidly. Capsule endoscopes generally include a capsule shell, lighting device, camera device, radio frequency transmitter, and battery. After the subject swallows the capsule endoscope, the pictures taken by the camera device placed at the transparent front end are wirelessly transmitted to the outside of the body. The inspectors made a reasonable judgment on the condition of the subject through the received pictures. Compared with the insertion-type gastrointestinal endoscope, the biggest advantage of the capsule endoscope is that it is painless, non-invasive, safe, and convenient, especially for the inspection of the small intestine.
目前的检查都会遇到一个问题，当胶囊内窥镜深入消化道腔体内部时存在大量消化道粘液和残渣，如果这些内容物粘附在胶囊内窥镜前壳表面，会对镜头拍摄图片形成干扰造成漏检。目前胶囊内窥镜表面处理方式有两种，第一种方法：增加表面能使表面水的浸润角度接近零，使水液在镜头表面均匀分散开，防止水汽对镜头视线的影响。这种做法多采用使用前喷涂方式，也有二氧化硅镀膜方式，是最为常见的内窥镜镜头表面处理方法，但喷涂方式持续时间短，高表面能会引起水中携带的消化道内容物沾粘，对胶囊内窥镜不是优化选择。第二种方法：减少表面能使水的浸润角度大于150度，液体在胶囊表面形成水滴滚落，但一直以来由于镀膜要求很高，成本高的原因在实际中没有大量使用。The current inspection will encounter a problem. When the capsule endoscope penetrates into the cavity of the digestive tract, there will be a lot of mucus and residues in the digestive tract. Interference caused missed detection. At present, there are two ways to treat the surface of the capsule endoscope. The first method is to increase the surface energy to make the infiltration angle of surface water close to zero, so that the water liquid can be evenly dispersed on the lens surface, and prevent the influence of water vapor on the lens line of sight. This method mostly adopts the method of spraying before use, and there is also the method of silica coating, which is the most common method for surface treatment of endoscope lenses, but the duration of the spraying method is short, and the high surface energy will cause the contents of the digestive tract carried in the water to stick , is not optimal for capsule endoscopy. The second method: reduce the surface energy so that the wetting angle of water is greater than 150 degrees, and the liquid forms water droplets on the surface of the capsule and rolls down. However, due to the high requirements and high cost of coating, it has not been widely used in practice.
有鉴于此，有必要对现有的胶囊状壳体、胶囊状壳体的制备方法及具有该胶囊状壳体的胶囊内窥镜予以改进，以解决上述问题。In view of this, it is necessary to improve the existing capsule shell, the preparation method of the capsule shell and the capsule endoscope with the capsule shell, so as to solve the above problems.
发明内容Contents of the invention
本发明要解决的技术问题是克服现有的缺陷，提供一种胶囊状壳体，其最外层经过纳米镀膜处理具有自清洁功能，能有效解决胶囊内窥镜工作时易沾染消化道粘液和残渣的问题，从而降低胶囊内窥镜的漏检率。The technical problem to be solved by the present invention is to overcome the existing defects and provide a capsule-shaped shell whose outermost layer has a self-cleaning function after nano-coating treatment, which can effectively solve the problem of easy contamination of digestive tract mucus and The problem of residues, thereby reducing the missed detection rate of capsule endoscopy.
为了解决上述技术问题，本发明提供一种胶囊状壳体，包括前端、壳主体以及尾部，前端、壳主体及尾部皆使用生物相容材料，前端透明，其特征在于：所述前端外表面具有增透膜以及位于所述增透膜外的防粘膜。In order to solve the above-mentioned technical problems, the present invention provides a capsule-shaped shell, which includes a front end, a shell body and a tail. The front end, the shell body and the tail are all made of biocompatible materials, and the front end is transparent. It is characterized in that: the outer surface of the front end has An antireflection film and an anti-adhesive film outside the antireflection film.
上述方案中，所述增透膜的最外层为SiO2镀膜。In the above solution, the outermost layer of the anti-reflection coating is SiO2 coating.
上述方案中，所述防粘膜为与SiO2镀膜进行反应或与SiO2镀膜化学亲和性强的的氟化物形成的氟化物镀膜。In the above solution, the anti-sticking film is a fluoride coating formed by reacting with the SiO2 coating or having a strong chemical affinity with the SiO2 coating.
进一步地，所述氟化物为CF3-(CF2)m-(CH2)n-R，其中m介于1～20，n介于1～20，R为SiCl3或SiF3。Further, the fluoride is CF3 -(CF2 )m -(CH2 )n -R, wherein m is between 1-20, n is between 1-20, and R is SiCl3 or SiF3 .
进一步地，所述防粘膜为单分子层薄膜。Further, the anti-adhesive film is a monolayer film.
进一步地，所述前端、壳主体及尾部的生物相容材料为聚碳酸酯或聚砜。Further, the biocompatible material of the front end, the shell body and the tail is polycarbonate or polysulfone.
进一步地，所述增透膜为TiO2纳米镀膜与SiO2纳米镀膜层叠形成的镀膜。Further, the anti-reflection film is a coating formed by stackingTiO2 nano-coating andSiO2 nano-coating.
进一步地，所述氟化物为CF3(CF2)5(CH2)2SiCl3或者CF3(CF2)5(CH2)2SiF3。Further, the fluoride is CF3 (CF2)5 (CH2)2 SiCl3 or CF3 (CF2)5 (CH2)2 SiF3 .
进一步地，所述壳主体和/或所述尾部的外表面具有增透膜以及位于所述增透膜外的防粘膜。Further, the outer surface of the shell body and/or the tail has an anti-reflection film and an anti-adhesive film outside the anti-reflection film.
进一步地，所述增透膜的外表面具有微纳结构。Further, the outer surface of the antireflection film has a micro-nano structure.
本发明还提供一种胶囊内窥镜，包括所述胶囊状壳体、照明装置、摄像装置、射频发射装置、电池。The present invention also provides a capsule endoscope, comprising the capsule casing, an illuminating device, an imaging device, a radio frequency transmitting device, and a battery.
上述方案中，所述胶囊内窥镜内部含有小磁体。In the above solution, the capsule endoscope contains small magnets inside.
本发明还提供一种制备胶囊状壳体的方法，所述胶囊状壳体包括前端、壳主体以及尾部，前端透明，制备胶囊状壳体的方法包括如下步骤：S1:提供用于制备胶囊状壳体的生物相容材料做为材料基质，在所述材料基质的外表面通过凝胶法、真空溅射法、真空蒸镀法镀上增透膜；S2：提供防粘膜材料，并于所述增透膜最外层形成防粘膜。The present invention also provides a method for preparing a capsule-shaped shell. The capsule-shaped shell includes a front end, a shell body and a tail. The front end is transparent. The method for preparing a capsule-shaped shell includes the following steps: S1: providing a The biocompatible material of the shell is used as the material matrix, and an anti-reflection film is coated on the outer surface of the material matrix by gel method, vacuum sputtering method, and vacuum evaporation method; S2: provide an anti-adhesive film material, and The outermost layer of the antireflection film forms an anti-adhesive film.
上述方案中，所述增透膜的最外层为SiO2镀膜；所述防粘膜为与SiO2镀膜进行反应的氟化物形成的氟化物镀膜。In the above solution, the outermost layer of the anti-reflection film is SiO2 coating; the anti-sticking film is a fluoride coating formed by fluoride reacting with the SiO2 coating.
上述方案中，还包括介于S1与S2之间的制微纳结构步骤，所述制微纳结构步骤为在前端、或者前端和壳主体、或者前端和壳主体和尾部的外表面经光刻或等离子轰击形成微纳结构。In the above scheme, the step of making a micronanostructure between S1 and S2 is also included, and the step of making a micronanostructure is to photoetch the outer surface of the front end, or the front end and the main body of the shell, or the front end, the main body of the shell and the tail. Or plasma bombardment to form micro-nano structures.
本发明的有益效果是：本发明的胶囊状壳体及含有这种胶囊状壳体的胶囊内窥镜，有效解决了目前检查过程中前端表面易沾染消化道粘液而导致图像不清晰的问题，能有效降低胶囊内窥镜检查的漏检率。The beneficial effects of the present invention are: the capsule-shaped casing of the present invention and the capsule endoscope containing the capsule-shaped casing effectively solve the problem that the front surface is easily contaminated with digestive tract mucus during the current inspection process, resulting in unclear images. It can effectively reduce the missed detection rate of capsule endoscopy.
附图说明Description of drawings
图1是本发明胶囊状壳体的结构示意图。Fig. 1 is a schematic diagram of the structure of the capsule shell of the present invention.
图2是氟化物在最外层为SiO2镀膜的增透膜外形成增透膜前的结构示意图。Fig. 2 is a schematic diagram of the structure of fluoride before forming an anti-reflection film outside the anti-reflection film whose outermost layer is SiO2 coating.
图3是另一实施例中氟化物在最外层为SiO2镀膜的增透膜外形成增透膜前的结构示意图。FIG. 3 is a schematic diagram of the structure of fluoride before forming an anti-reflection film outside the anti-reflection film whose outermost layer is SiO2 coating in another embodiment.
图4是本发明的增透膜的最外层被光刻或等离子轰击形成微纳结构后的展开结构图。Fig. 4 is a diagram showing the unfolded structure of the outermost layer of the anti-reflection coating of the present invention formed by photolithography or plasma bombardment to form a micro-nano structure.
图5是图4于另一角度的视图。FIG. 5 is a view of FIG. 4 from another angle.
图6是氟化物在最外层为SiO2镀膜且具有微纳结构的增透膜外形成增透膜前的结构示意图。6 is a schematic diagram of the structure of fluoride before forming an anti-reflection film outside the anti-reflection film whose outermost layer is SiO2 coating and has a micro-nano structure.
图7另一实施例中氟化物在最外层为SiO2镀膜且具有微纳结构的增透膜外形成增透膜前的结构示意图。FIG. 7 is a schematic diagram of the structure of fluoride before forming an anti-reflection film outside the anti-reflection film with a SiO2 coating and a micro-nano structure in another embodiment.
图8为氟化物在SiO2镀膜形成防粘膜的示意图。Fig. 8 is a schematic diagram of fluoride coating on SiO2 to form an anti-adhesive film.
图9为具有增透膜和防粘膜的胶囊状壳体外表面遇水滴自动滚落的示意图。Fig. 9 is a schematic diagram of the outer surface of the capsule-shaped shell with the anti-reflection film and the anti-adhesive film automatically rolling down when encountering water droplets.
图10为本发明的胶囊内窥镜的分解图。Fig. 10 is an exploded view of the capsule endoscope of the present invention.
具体实施方式Detailed ways
下面结合附图和具体实施例对本发明作进一步的详细说明，以下实施例是对本发明的解释而本发明并不局限于以下实施例。The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. The following embodiments are explanations of the present invention and the present invention is not limited to the following embodiments.
如图1～图10所示，本发明提供一种胶囊状壳体及采用该胶囊状壳体的胶囊内窥镜。As shown in FIGS. 1 to 10 , the present invention provides a capsule-shaped casing and a capsule endoscope using the capsule-shaped casing.
请参阅图10所示，所述胶囊内窥镜包括胶囊状壳体、位于所述胶囊状壳体内的照明装置22、摄像装置23、电池24、射频发射装置25及小磁体(未图示)。Please refer to FIG. 10 , the capsule endoscope includes a capsule housing, an illuminating device 22 located in the capsule housing, an imaging device 23, a battery 24, a radio frequency transmitting device 25 and a small magnet (not shown). .
胶囊状壳体又分为前端11、壳主体12以及尾部13，前端11、壳主体12及尾部13皆使用聚碳酸酯(PC)或聚砜(PSF)等生物相容材料。且前端11透明。照明装置22、摄像装置23位于前端11，便于很好地摄取消化道腔体内的情况。The capsule shell is further divided into a front end 11, a shell body 12 and a tail 13. The front end 11, the shell body 12 and the tail 13 are all made of biocompatible materials such as polycarbonate (PC) or polysulfone (PSF). And the front end 11 is transparent. The illuminating device 22 and the camera device 23 are located at the front end 11, which is convenient for photographing the situation in the digestive tract cavity well.
以下将结合具体实施例详细说明所述胶囊状壳体的结构及其制备方法。The structure of the capsule shell and its preparation method will be described in detail below in conjunction with specific examples.
所述前端11外表面具有增强透光率的增透膜以及位于所述增透膜外的防粘膜，所述防粘膜与所述增透膜的最外层之间具有很强的结合力，以防止所述防粘膜脱落。The outer surface of the front end 11 has an anti-reflection film with enhanced light transmittance and an anti-adhesive film outside the anti-reflection film. There is a strong bonding force between the anti-adhesive film and the outermost layer of the anti-reflection film. To prevent the detachment of the anti-adhesive film.
所述增透膜是为了提高胶囊状壳体尤其是前端11的透光性，以免对摄像装置23的拍摄造成光线影响。所述增透膜可以由多层交替形成多层干涉膜，其中各层的材料选择和厚度等参数由增透波长的范围决定。于其中一个实施例中，所述增透膜的最外层为SiO2镀膜，便于在其外表面进一步形成防粘膜。进一步地，所述增透膜为TiO2纳米镀膜与SiO2纳米镀膜层叠形成的镀膜，如TiO2、SiO2、TiO2、SiO2、TiO2、SiO2镀膜，对可见光部分增透，减少反射，透光性能好。当然，在其他实施例中，上述增透膜的材料选择还可以增加或替换为氟化钙、氟化镁等，以达到相同的效果。The anti-reflection film is used to improve the light transmittance of the capsule-shaped casing, especially the front end 11 , so as not to affect the shooting of the camera 23 by light. The anti-reflection film can be formed of multiple layers alternately to form a multi-layer interference film, wherein parameters such as material selection and thickness of each layer are determined by the range of the anti-reflection wavelength. In one of the embodiments, the outermost layer of the anti-reflection film is SiO2 coating, which is convenient for further forming an anti-sticking film on its outer surface. Further, the anti-reflection film is a coating formed by laminatingTiO2 nano-coating andSiO2 nano-coating, such asTiO2 ,SiO2 ,TiO2 ,SiO2 ,TiO2 ,SiO2 coating, which can increase the reflection of visible light and reduce Reflection, light transmission performance is good. Of course, in other embodiments, the material selection of the anti-reflection film can also be added or replaced with calcium fluoride, magnesium fluoride, etc., so as to achieve the same effect.
防粘膜透明、无毒且具有较小的表面能，其浸润角大于100°或滚动角较小；如浸润角为100°，110°，120°，130°，140°，150°，160°，170°，175°；滚动角为：5°，10°，15°，20°，30°，40°，50°，60°，70°等；可有效防止消化道粘液和残渣粘附在前端11的外表面，从而避免对摄像装置23拍摄图片形成干扰造成漏检。The anti-mucosal film is transparent, non-toxic and has a small surface energy, and its wetting angle is greater than 100° or the rolling angle is small; if the wetting angle is 100°, 110°, 120°, 130°, 140°, 150°, 160° , 170°, 175°; rolling angles: 5°, 10°, 15°, 20°, 30°, 40°, 50°, 60°, 70°, etc.; can effectively prevent the mucus and residues of the digestive tract from adhering to the The outer surface of the front end 11, so as to avoid interference with the pictures taken by the camera device 23 and cause missed detection.
为了增强防粘膜与增透膜之间的结合力，避免防粘膜在胶囊状外壳使用过程中脱落，所述防粘膜由可与所述增透膜的最外层材料进行反应并在所述增透膜的外表面形成薄膜的材料形成，或者防粘膜由与所述增透膜的最外层材料化学亲和性强的材料形成。其中，化学亲和性强是指两种材料具有相似或相互吸引的基团，使得两种材料之间的作用力强。In order to enhance the bonding force between the anti-adhesive film and the anti-reflection film and avoid the anti-adhesive film from falling off during the use of the capsule shell, the anti-adhesive film is made of materials that can react with the outermost layer of the anti-reflection film and react with the anti-reflection film. The outer surface of the anti-reflection film is made of a material that forms a thin film, or the anti-adhesive film is made of a material that has a strong chemical affinity with the material of the outermost layer of the anti-reflection film. Among them, strong chemical affinity means that two materials have similar or mutually attractive groups, so that the interaction force between the two materials is strong.
请参阅图8所示，基于最外层为SiO2镀膜的增透膜，所述防粘膜为可与SiO2镀膜进行反应的氟化物形成的氟化物镀膜。优选的，所述氟化物为CF3-(CF2)m-(CH2)n-R，其中m介于1～20，n介于1～20，R为SiCl3或SiF3。将CF3-(CF2)m-(CH2)n-R用于外层镀膜是未来半导体4nm生产技术nanoimprint的核心。CF3-(CF2)m-(CH2)n-R与SiO2镀膜基材表面可以在气相或溶液中反应，CF3-(CF2)m-(CH2)n-R与SiO2镀膜通过Si-O-Si键结合，由于CF3-(CF2)m-(CH2)n-R分子链两端的性能差别，只会在SiO2镀膜基材表面形成单分层子的无毒透明纳米薄层防粘膜。Please refer to FIG. 8 , based on the antireflection coating whose outermost layer is SiO2 coating, the anti-sticking film is a fluoride coating formed by fluoride that can react with SiO2 coating. Preferably, the fluoride is CF3 -(CF2 )m -(CH2 )n -R, wherein m is between 1-20, n is between 1-20, and R is SiCl3 or SiF3 . The use of CF3 -(CF2 )m -(CH2 )n -R for outer layer coating is the core of nanoimprint, the future semiconductor 4nm production technology. CF3 -(CF2 )m -(CH2 )n -R and SiO2 coated substrate surface can react in gas phase or solution, CF3 -(CF2 )m -(CH2 )n -R and SiO2 The coating is bonded by Si-O-Si bonds, and due to the difference in properties between the two ends of the CF3 -(CF2 )m -(CH2 )n -R molecular chain, only a single layer of molecular molecules will be formed on the surface of the SiO2 coating substrate. Toxic transparent nano thin layer anti-adhesive film.
本发明例举所述氟化物为可与SiO2镀膜进行反应的CF3(CF2)5(CH2)2SiCl3或者CF3(CF2)5(CH2)2SiF3、CF3(CF2)7(CH2)3SiF3、CF3(CF2)2CH2SiF3等。将CF3(CF2)5(CH2)2SiCl3或者CF3(CF2)5(CH2)2SiF3等氟化物用于外层镀膜是未来半导体4nm生产技术nanoimprint的核心。CF3(CF2)5(CH2)2SiCl3或者CF3(CF2)5(CH2)2SiF3与SiO2镀膜基材表面可以在气相或溶液中反应，两者通过Si-O-Si键结合在一起，由于其分子链两端的性能差别，CF3(CF2)5(CH2)2SiCl3或者CF3(CF2)5(CH2)2SiF3只会在SiO2镀膜基材表面形成单分层子的无毒透明纳米薄层防粘膜。The present invention exemplifies that the fluoride is CF3 (CF2)5 (CH2)2 SiCl3 or CF3 (CF2)5 (CH2)2 SiF3 , CF3 (CF2 )7 which can react with SiO2 coating (CH2 )3 SiF3 , CF3 (CF2 )2 CH2 SiF3 , etc. The use of fluorides such as CF3 (CF2 )5 (CH2 )2 SiCl3 or CF3 (CF2)5 (CH2)2 SiF3 for outer layer coating is the core of nanoimprint, the future semiconductor 4nm production technology. The surface of CF3 (CF2 )5 (CH2 )2 SiCl3 or CF3 (CF2)5 (CH2)2 SiF3 and SiO2 coated substrate can react in gas phase or solution, and the two pass Si-O-Si Bonded together, due to the performance difference at both ends of its molecular chain, CF3 (CF2 )5 (CH2 )2 SiCl3 or CF3 (CF2)5 (CH2)2 SiF3 will only be on the surface of SiO2 coating substrate A non-toxic transparent nano-thin anti-adhesive film that forms a monolayer of molecules.
图2、图3所示为CF3-(CF2)m-(CH2)n-R在最外层为SiO2镀膜的增透膜外形成防粘膜前的结构示意图；图6、图7所示为CF3-(CF2)m-(CH2)n-R在最外层为SiO2镀膜且具有微纳结构的增透膜外形成防粘膜前的结构示意图；请参阅图8所示，一旦CF3-(CF2)m-(CH2)n-R在SiO2镀膜外形成了增透膜，则CF3-(CF2)m-(CH2)n-R与SiO2镀膜通过Si-O-Si键结合。进一步相邻的CF3-(CF2)m-(CH2)n-R之间也会通过Si-O-Si键结合在一起。Fig. 2 and Fig. 3 are schematic diagrams showing the structure of CF3 -(CF2 )m -(CH2 )n -R before forming an anti-adhesive film outside the anti-reflective coating with SiO2 coating on the outermost layer; Fig. 6 and Fig. 7 Shown is a schematic diagram of the structure of CF3 -(CF2 )m -(CH2 )n -R before forming an anti-adhesive film on the outermost antireflection film coated with SiO2 and having a micro-nano structure; please refer to Figure 8 It shows that once CF3 -(CF2 )m -(CH2 )n -R forms an anti-reflective coating outside the SiO2 coating, then CF3 -(CF2 )m -(CH2 )n -R and SiO2 Coatings are bonded by Si-O-Si bonds. Further adjacent CF3 -(CF2 )m -(CH2 )n -R will also be bonded together through Si-O-Si bonds.
于另外的实施例中，所述增透膜的外表面具有微米级、亚微米级或纳米级的微纳结构，从而使得位于该微纳结构外的防粘膜的粗糙度增大，以进一步减少防粘膜的表面能，更加有效地防止消化道粘液和残渣粘附在前端11的外表面。胶囊外壳表面的微纳结构可以提高等效浸润角，其中部分空气被封于界面处的微纳结构之间，使滚动角进一步减小，便于胶囊外壳实现自洁功能。In another embodiment, the outer surface of the anti-reflection film has a micron-scale, sub-micron-scale or nano-scale micro-nano structure, so that the roughness of the anti-adhesive film outside the micro-nano structure is increased to further reduce The surface energy of the anti-mucosal film can more effectively prevent mucus and residues of the digestive tract from adhering to the outer surface of the front end 11 . The micro-nano structure on the surface of the capsule shell can increase the equivalent wetting angle, and part of the air is sealed between the micro-nano structures at the interface, which further reduces the rolling angle and facilitates the self-cleaning function of the capsule shell.
另外，所述壳主体12和/或所述尾部13的外表面也具有上述增透膜以及位于所述增透膜外的防粘膜；所述增透膜包括外表面是否具有微纳结构两种。具体结构有：所述前端11具有上述具有微纳结构或不具有微纳结构的增透膜、防粘膜；所述前端11、主壳体12均具有上述具有微纳结构或不具有微纳结构的增透膜、防粘膜；所述前端11、尾部13均具有上述具有微纳结构或不具有微纳结构的增透膜、防粘膜；前端11、主壳体12和尾部13均具有上述具有微纳结构或不具有微纳结构的增透膜、防粘膜。In addition, the outer surface of the shell main body 12 and/or the tail 13 also has the above-mentioned anti-reflection film and an anti-adhesive film outside the anti-reflection film; the anti-reflection film includes whether the outer surface has a micro-nano structure. . The specific structure is as follows: the front end 11 has the above-mentioned anti-reflection film and anti-adhesive film with a micro-nano structure or without a micro-nano structure; The anti-reflection film and anti-adhesive film; the front end 11 and the tail part 13 all have the above-mentioned anti-reflection film and anti-adhesion film with or without micro-nano structure; the front end 11, the main casing 12 and the tail part 13 all have the above-mentioned Anti-reflection film and anti-adhesive film with micro-nano structure or without micro-nano structure.
在所述壳主体12和/或所述尾部13的外表面不具有防粘膜的实施例中，所述壳主体12和/或所述尾部13的摩擦力大于前端11，在外部磁场控制胶囊内窥镜运动的过程中可作为相对固定的支点停靠于消化道内腔壁上，以使得前端11处于最佳角度，便于拍摄。In the embodiment in which the outer surface of the shell body 12 and/or the tail portion 13 does not have an anti-adhesive film, the friction force of the shell body 12 and/or the tail portion 13 is greater than that of the front end 11, and in the external magnetic field control capsule During the movement of the speculum, it can be used as a relatively fixed fulcrum to rest on the lumen wall of the digestive tract, so that the front end 11 is at an optimal angle for easy shooting.
在前端11、主壳体12和尾部13均具有防粘膜的实施例中，所述胶囊状壳体整体运行较为灵活，阻力小，转动角度360无死角。In the embodiment in which the front end 11 , the main housing 12 and the tail 13 all have an anti-adhesive film, the overall operation of the capsule-shaped housing is more flexible, the resistance is small, and the rotation angle 360 has no dead angle.
本发明还提供一种制备上述胶囊状壳体的方法，包括如下步骤:The present invention also provides a method for preparing the above-mentioned capsule shell, comprising the steps of:
S1:提供用于制备胶囊状壳体的生物相容材料做为材料基质，在所述材料基质的外表面通过凝胶法、真空溅射法、真空蒸镀法镀上增透膜；S1: provide a biocompatible material for preparing a capsule-shaped shell as a material matrix, and coat an anti-reflection film on the outer surface of the material matrix by gel method, vacuum sputtering method, or vacuum evaporation method;
S2：提供可与所述增透膜的最外层材料进行反应、或者与所述增透膜的最外层材料化学亲和性强的材料作为防粘膜材料，并于所述增透膜最外层形成防粘膜。S2: Provide a material that can react with the outermost material of the anti-reflection film, or has a strong chemical affinity with the outermost material of the anti-reflection film as an anti-adhesive film material, and place it on the outermost layer of the anti-reflection film The outer layer forms an anti-adhesive film.
优选的实施例中，所述增透膜的最外层为SiO2镀膜；所述防粘膜为与SiO2镀膜进行反应的氟化物形成的氟化物镀膜。氟化物与SiO2薄膜可在气象或溶液中反应形成防粘膜，具体地，在室温下，氟化物在真空挥发到SiO2表面，通少量水汽反应，形成薄膜。具体真空度根据氟化物的挥发性质设定。生产使用低真空环境，设备成本和材料成本低。In a preferred embodiment, the outermost layer of the anti-reflection film is SiO2 coating; the anti-sticking film is a fluoride coating formed by fluoride reacting with the SiO2 coating. Fluoride andSiO2 films can react in the atmosphere or in solution to form an anti-adhesive film. Specifically, at room temperature, fluoride volatilizes to the surface ofSiO2 in a vacuum, and reacts with a small amount of water vapor to form a film. The specific vacuum degree is set according to the volatile properties of the fluoride. The production uses a low vacuum environment, and the equipment cost and material cost are low.
进一步地，制备上述胶囊状壳体的方法还包括介于S1与S2之间的制微纳结构步骤，所述制微纳结构步骤为在前端11、或者前端11和壳主体12、或者前端11和尾部13或者前端11和壳主体12和尾部13的外表面经光刻或等离子轰击等形成微纳结构。以下为几种胶囊状壳体的结构及其制备方法。Further, the method for preparing the above-mentioned capsule-shaped shell also includes a step of making a micro-nano structure between S1 and S2. and the tail part 13 or the outer surfaces of the front end 11 and the shell body 12 and the tail part 13 to form a micro-nano structure through photolithography or plasma bombardment. The structures and preparation methods of several capsule shells are as follows.
实施例一Embodiment one
图1为本发明胶囊状壳体的结构示意图，它包括前端11、壳主体12以及尾部13。前端11透明，对应内部的位置放置摄像装置。前端11、壳主体12及尾部13皆为聚碳酸酯且外表面都经过镀膜处理。FIG. 1 is a schematic diagram of the structure of the capsule-shaped shell of the present invention, which includes a front end 11 , a shell body 12 and a tail 13 . The front end 11 is transparent, and the camera device is placed in a position corresponding to the inside. The front end 11 , the shell body 12 and the tail 13 are all made of polycarbonate and the outer surfaces are all coated.
前端11外表面如图2那样通过凝胶法、真空溅射法、真空蒸镀法镀上依次镀上14.96nm的TiO2、32.3nm的SiO2、49.78nm的TiO2、15nm的SiO2、37.86nm的TiO2、93.01nm的SiO2形成增透膜，最后采用CF3(CF2)5(CH2)2SiCl3在SiO2薄膜外表面进行纳米镀膜。关于增透膜各层的厚度可以根据需要做适当的调整，以下实施例参考本实施例的厚度或在本实施例的厚度的基础上做适应性修改，将不再赘述。CF3(CF2)5(CH2)2SiCl3这种材料用于胶囊状壳体镀膜最外层时能使防粘膜的浸润角大于130°，具有很好的防粘效果，降低胶囊内窥镜的漏检率。The outer surface of the front end 11 is plated sequentially with 14.96nm TiO2 , 32.3nm SiO2 , 49.78nm TiO2 , 15nm SiO2 , 37.86nm TiO2 and 93.01nm SiO2 form an anti-reflection coating, and finally use CF3 (CF2 )5 (CH2 )2 SiCl3 to perform nano-coating on the outer surface of the SiO2 film. The thickness of each layer of the anti-reflection film can be appropriately adjusted according to the needs. The following embodiments refer to the thickness of this embodiment or make adaptive modifications on the basis of the thickness of this embodiment, and will not repeat them. When CF3 (CF2 )5 (CH2 )2 SiCl3 is used for coating the outermost layer of the capsule-shaped shell, the wetting angle of the anti-adhesive film can be greater than 130°, which has a good anti-adhesive effect and reduces the internal pressure of the capsule. The missed detection rate of the speculum.
请参阅图8所示，将CF3(CF2)5(CH2)2SiCl3用于外层镀膜是未来半导体4nm生产技术nanoimprint的核心。CF3(CF2)5(CH2)2SiCl3与SiO2镀膜基材表面可以在气相或溶液中反应，并以CF3-(CF2)m-(CH2)n-SiCl2-O-Si结合于SiO2镀膜外，由于其分子链两端的性能差别，CF3(CF2)5(CH2)2SiCl3只会在SiO2镀膜基材表面形成单分层子的无毒透明纳米薄层防粘膜。进一步地，相邻的两个CF3-(CF2)m-(CH2)n-SiCl2-O-之间也通过Si-O-Si键结合在一起。于其他实施例中，CF3-(CF2)m-(CH2)n-R在SiO2镀膜外形成增透膜的机理相同，不再赘述。于本实施例中，将增透膜最外层为SiO2薄膜的胶囊状壳体及CF3(CF2)5(CH2)2SiCl3防粘膜材料放置于真空箱中，抽真空20min后再打开真空箱，通入少量水汽反应，形成防粘膜。Please refer to Figure 8, the use of CF3 (CF2 )5 (CH2 )2 SiCl3 for outer layer coating is the core of nanoimprint, the future semiconductor 4nm production technology. CF3 (CF2 )5 (CH2 )2 SiCl3 and SiO2 coated substrate surface can react in the gas phase or in solution, and form CF3 -(CF2 )m -(CH2 )n -SiCl2 -O -Si is combined outside the SiO2 coating, due to the performance difference at both ends of its molecular chain, CF3 (CF2 )5 (CH2 )2 SiCl3 will only form a single layer of non-toxic and transparent molecules on the surface of the SiO2 coating substrate Nano-thin anti-adhesive film. Further, two adjacent CF3 -(CF2 )m -(CH2 )n -SiCl2 -O- are also bonded together through Si-O-Si bonds. In other embodiments, the mechanism of CF3 -(CF2 )m -(CH2 )n -R forming the anti-reflection film outside the SiO2 coating is the same, and will not be repeated here. In this embodiment, the outermost layer of anti-reflection film is the capsule shell of SiO2 film and CF3 (CF2 )5 (CH2 )2 SiCl3 anti-adhesive film material are placed in a vacuum box, after 20 minutes of vacuuming Open the vacuum box again, feed a small amount of water vapor to react, and form an anti-adhesive film.
当然，用作防粘膜的最外层材料还可以为CF3CF2(CH2)20SiCl3、CF3(CF2)2(CH2)13SiCl3、CF3(CF2)18(CH2)5SiCl3、CF3(CF2)20(CH2)3SiCl3、CF3(CF2)8(CH2)8SiCl3等氟化物。Of course, the outermost material used as the anti-adhesive film can also be CF3 CF2 (CH2 )20 SiCl3 , CF3 (CF2 )2 (CH2 )13 SiCl3 , CF3 (CF2 )18 (CH2 )5 SiCl3 , CF3 (CF2 )20 (CH2 )3 SiCl3 , CF3 (CF2 )8 (CH2 )8 SiCl3 and other fluorides.
实施例二Embodiment two
图1为本发明胶囊状壳体的结构示意图，它包括前端11、壳主体12以及尾部13。前端11透明，对应内部的位置放置摄像装置。将前端11、壳主体12的外表面如图3那样依次镀上TiO2、SiO2、TiO2、SiO2、TiO2、SiO2形成增透膜，最后采用CF3(CF2)7(CH2)3SiF3在SiO2薄膜外表面进行纳米镀膜。尾部13最外层不镀CF3(CF2)7(CH2)3SiF3这种材料，使尾部13最外表面的浸润角小于前端11和壳主体12的浸润角，尾部13最外表面的磨擦力大于前端11和壳主体12，当这种胶囊状壳体用于胶囊内窥镜外壳时，外部磁场可以对含有磁性的胶囊内窥镜进行控制，则摩擦力较大的尾部13可作为相对固定的支点，以控制前端11处于最佳角度。此外，这种方式也能通过在磁场控制下胶囊的晃动和与消化道内壁的接触擦拭实现自清洁功能，有效解决了胶囊内窥镜在检查过程中容易沾染肠道粘液致使漏检率增大的问题。FIG. 1 is a schematic diagram of the structure of the capsule-shaped shell of the present invention, which includes a front end 11 , a shell body 12 and a tail 13 . The front end 11 is transparent, and the camera device is placed in a position corresponding to the inside. The front end 11 and the outer surface of the shell main body 12 are sequentially coated with TiO2 , SiO2 , TiO2 , SiO2 , TiO2 , and SiO2 as shown in Figure 3 to form an anti-reflection coating, and finally CF3 (CF2 )7 (CH2 )3 SiF3 is nano-coated on the outer surface of SiO2 film. The outermost layer of the tail 13 is not coated with CF3 (CF2 )7 (CH2 )3 SiF3 material, so that the wetting angle of the outermost surface of the tail 13 is smaller than that of the front end 11 and the shell body 12, and the outermost surface of the tail 13 The friction force is greater than that of the front end 11 and the shell body 12. When this capsule-shaped shell is used for the capsule endoscope shell, the external magnetic field can control the magnetic capsule endoscope, and the tail portion 13 with greater friction can be As a relatively fixed fulcrum to control the front end 11 at an optimal angle. In addition, this method can also realize the self-cleaning function through the shaking of the capsule under the control of the magnetic field and the contact wiping with the inner wall of the digestive tract, which effectively solves the problem that the capsule endoscope is easily contaminated with intestinal mucus during the inspection process, resulting in an increase in the missed detection rate. The problem.
当然，也可以在前端11、尾部13的外表面如图2那样依次镀上TiO2、SiO2、TiO2、SiO2、TiO2、SiO2形成增透膜，最后采用CF3(CF2)5(CH2)2SiCl3在SiO2薄膜外表面进行纳米镀膜。壳主体12最外层不镀CF3(CF2)5(CH2)2SiCl3这种材料，壳主体12最外表面的浸润角小于前端11和尾部13的浸润角，壳主体12最外表面的磨擦力大于前端11和尾部13，当这种胶囊状壳体用于胶囊内窥镜外壳时，外部磁场可以对含有磁性的胶囊内窥镜进行控制，则摩擦力较大的壳主体12可作为相对固定的支点，以控制前端11处于最佳角度。此外，这种方式也能通过在磁场控制下胶囊的晃动和与消化道内壁的接触擦拭实现自清洁功能，有效解决了胶囊内窥镜在检查过程中容易沾染肠道粘液致使漏检率增大的问题。Of course, TiO2 , SiO2 , TiO2 , SiO2 , TiO2 , and SiO2 can also be sequentially coated on the outer surfaces of the front end 11 and tail 13 as shown in Figure 2 to form an anti-reflection coating, and finally CF3 (CF2 )5 (CH2 )2 SiCl3 is used for nano-coating on the outer surface of SiO2 film. The outermost layer of the shell body 12 is not coated with CF3 (CF2 )5 (CH2 )2 SiCl3 material, the wetting angle of the outermost surface of the shell body 12 is smaller than that of the front end 11 and the tail 13, and the outermost surface of the shell body 12 The friction force of the surface is greater than that of the front end 11 and the tail portion 13. When this capsule-shaped shell is used for the capsule endoscope shell, the external magnetic field can control the magnetic capsule endoscope, and the shell body 12 with greater friction It can be used as a relatively fixed fulcrum to control the front end 11 at an optimal angle. In addition, this method can also realize the self-cleaning function through the shaking of the capsule under the control of the magnetic field and the contact wiping with the inner wall of the digestive tract, which effectively solves the problem that the capsule endoscope is easily contaminated with intestinal mucus during the inspection process, resulting in an increase in the missed detection rate. The problem.
当然，用作防粘膜的最外层材料还可以为CF3CF2(CH2)20SiF3、CF3(CF2)2(CH2)13SiF3、CF3(CF2)18(CH2)5SiF3、CF3(CF2)20(CH2)3SiF3、CF3(CF2)8(CH2)8SiF3等氟化物。Of course, the outermost material used as the anti-adhesive film can also be CF3 CF2 (CH2 )20 SiF3 , CF3 (CF2 )2 (CH2 )13 SiF3 , CF3 (CF2 )18 (CH2 ) Fluorides such as5 SiF3 , CF3 (CF2 )20 (CH2 )3 SiF3 , CF3 (CF2 )8 (CH2 )8 SiF3 .
实施例三Embodiment three
胶囊状壳体依然如图1所示，包括前端11、壳主体12以及尾部13，他们组成材料为聚砜(PSF)。将前端11、壳主体12以及尾部13的外表面如图2那样依次镀上TiO2、SiO2、TiO2、SiO2、TiO2、SiO2形成增透膜，最后采用CF3(CF2)5(CH2)2SiCl3在SiO2薄膜外表面进行纳米镀膜。这样的胶囊状壳体用于胶囊内窥镜外壳时，胶囊状外壳表面的纳米级单层低表面能高分子材料使胶囊表面不沾，有效降低胶囊内窥镜的漏检率。The capsule-shaped shell is still shown in FIG. 1 , including a front end 11 , a shell body 12 and a tail 13 , which are made of polysulfone (PSF). The outer surfaces of the front end 11, the shell body 12, and the tail 13 are sequentially coated with TiO2 , SiO2 , TiO2 , SiO2 , TiO2 , and SiO2 as shown in Figure 2 to form an anti-reflection coating, and finally CF3 (CF2 )5 (CH2 )2 SiCl3 is used for nano-coating on the outer surface of SiO2 film. When such a capsule shell is used for the shell of a capsule endoscope, the nanoscale single-layer low surface energy polymer material on the surface of the capsule shell makes the surface of the capsule non-stick, effectively reducing the missed detection rate of the capsule endoscope.
实施例四Embodiment four
胶囊状壳体依然如图1所示，包括前端11、壳主体12以及尾部13，他们组成材料为聚碳酸酯(PC)，将前端11、壳主体12以及尾部13的外表面如图3那样依次镀上TiO2、SiO2、TiO2、SiO2、TiO2、SiO2形成增透膜，最后采用CF3(CF2)7(CH2)3SiF3在SiO2薄膜外表面进行纳米镀膜形成防粘膜。这样的胶囊状壳体用于胶囊内窥镜外壳时，胶囊状外壳表面的纳米级单层低表面能高分子材料使胶囊表面不沾，这样能有效降低胶囊内窥镜的漏检率。The capsule-shaped shell is still shown in Figure 1, including the front end 11, the shell body 12 and the tail part 13. Plate TiO2 , SiO2 , TiO2 , SiO2 , TiO2 , and SiO2 in sequence to form an anti-reflection coating, and finally use CF3 (CF2 )7 (CH2 )3 SiF3 to perform nano-coating on the outer surface of the SiO2 film Forms an anti-adhesive film. When such a capsule shell is used for the shell of a capsule endoscope, the nano-scale single-layer low surface energy polymer material on the surface of the capsule shell makes the surface of the capsule non-stick, which can effectively reduce the missed detection rate of the capsule endoscope.
实施例五Embodiment five
胶囊状壳体依然如图1所示，包括前端11、壳主体12以及尾部13，他们组成材料为聚碳酸酯(PC)。将前端11、壳主体12的外表面如图6那样依次镀上TiO2、SiO2、TiO2、SiO2、TiO2、SiO2形成增透膜，然后经过光刻形成如图4那样的SiO2微纳结构，最后采用CF3(CF2)5(CH2)2SiCl3在SiO2微纳结构外表面进行纳米镀膜形成防粘膜。尾部13的外表面最外层不镀CF3(CF2)5(CH2)2SiCl3防粘膜，使得尾部13的浸润角小于前端11和壳主体12的浸润角，尾部13最外表面的磨擦力大于前端11和壳主体12，当这种胶囊状壳体用于胶囊内窥镜外壳时，外部磁场可以对含有磁性的胶囊内窥镜进行控制，则摩擦力较大的尾部13可作为相对固定的支点，以控制前端11处于最佳角度。此外，这种方式也能通过在磁场控制下胶囊的晃动和与消化道内壁的接触擦拭实现自清洁功能。The capsule-shaped shell is still shown in FIG. 1 , including a front end 11 , a shell body 12 and a tail 13 , which are made of polycarbonate (PC). The front end 11 and the outer surface of the shell body 12 are sequentially coated with TiO2 , SiO2 , TiO2 , SiO2 , TiO2 , and SiO2 as shown in Figure 6 to form an anti-reflection coating, and then photolithography is used to form SiO as shown in Figure 42 micro-nano structure, and finally use CF3 (CF2 )5 (CH2 )2 SiCl3 to perform nano-coating on the outer surface of the SiO2 micro-nano structure to form an anti-adhesive film. The outermost layer of the outer surface of the tail 13 is not coated with CF3 (CF2 )5 (CH2 )2 SiCl3 anti-adhesive film, so that the wetting angle of the tail 13 is smaller than that of the front end 11 and the shell body 12, and the outermost surface of the tail 13 The friction force is greater than that of the front end 11 and the shell body 12. When this capsule-shaped shell is used for the shell of a capsule endoscope, the external magnetic field can control the magnetic capsule endoscope, and the tail 13 with greater friction can be used as Relatively fixed fulcrum to control the front end 11 at an optimal angle. In addition, this method can also realize the self-cleaning function through the shaking of the capsule under the control of the magnetic field and the contact wiping with the inner wall of the digestive tract.
如图9所示，当镀膜后外壳表面有水滴时，外磁场控制下胶囊内窥镜晃动，水滴自动从外表面滚落，实现自清洁功能，有效解决了胶囊内窥镜在检查过程中容易沾染肠道粘液致使漏检率增大的问题。As shown in Figure 9, when there are water droplets on the surface of the shell after coating, the capsule endoscope shakes under the control of the external magnetic field, and the water droplets automatically roll down from the outer surface, realizing the self-cleaning function, which effectively solves the problem that the capsule endoscope is prone to problems during the inspection process. Contamination of intestinal mucus leads to an increase in the missed detection rate.
实施例六Embodiment six
胶囊状壳体依然如图1所示，包括前端11、壳主体12以及尾部13，他们组成材料为聚碳酸酯(PC)，将前端11、壳主体12以及尾部13的外表面如图7那样依次镀上TiO2、SiO2、TiO2、SiO2、TiO2、SiO2形成增透膜，然后经过等离子轰击形成如图4和图5那样的SiO2微纳结构。其中图4是本发明的增透膜的最外层被光刻或等离子轰击形成微纳结构后的展开结构图，图5是图4于另一角度的视图，最后采用CF3(CF2)2CH2SiF3在SiO2薄膜外表面进行纳米镀膜形成防粘膜。这样的胶囊状壳体用于胶囊内窥镜外壳时，胶囊状外壳表面的微纳结构和纳米级单层低表面能高分子材料使胶囊表面不沾，这样能有效降低胶囊内窥镜的漏检率。The capsule-shaped shell is still shown in Figure 1, including the front end 11, the shell body 12 and the tail part 13. TiO2 , SiO2 , TiO2 , SiO2 , TiO2 , and SiO2 are sequentially plated to form an anti-reflection coating, and then the SiO2 micro-nano structure as shown in Figure 4 and Figure 5 is formed by plasma bombardment. Wherein Fig. 4 is the unfolded structure diagram after the outermost layer of the anti-reflection coating of the present invention is formed by photolithography or plasma bombardment to form a micro-nano structure, and Fig. 5 is a view of Fig. 4 from another angle, and finally adopts CF3 (CF2 )2 CH2 SiF3 is nano-coated on the outer surface of the SiO2 film to form an anti-adhesive film. When such a capsule shell is used for the shell of a capsule endoscope, the micro-nano structure and nano-scale single-layer low surface energy polymer material on the surface of the capsule shell make the surface of the capsule non-stick, which can effectively reduce the leakage of the capsule endoscope. inspection rate.
实施例七Embodiment seven
图10为含有胶囊状壳体的胶囊内窥镜示意图，包括胶囊状壳体、照明装置22、摄像装置23、电池24、射频发射装置25，胶囊状壳体又分为前端11、壳主体12以及尾部13。Figure 10 is a schematic diagram of a capsule endoscope with a capsule-shaped shell, including a capsule-shaped shell, an illumination device 22, a camera 23, a battery 24, and a radio frequency transmitter 25. The capsule-shaped shell is further divided into a front end 11 and a shell body 12 and tail 13.
胶囊状壳体的材料为聚碳酸酯(PC)，且外表面都经过镀膜处理。前端11外表面如图6那样依次镀上TiO2、SiO2、TiO2、SiO2、TiO2、SiO2形成增透膜，然后经光刻后表面形成如图4和图5那样的SiO2微纳结构，其中图4是本发明的增透膜的最外层被光刻或等离子轰击形成微纳结构后的展开结构图，图5是图4于另一角度的视图，最后采用CF3(CF2)5(CH2)2SiCl3在SiO2薄膜外表面进行纳米镀膜形成防粘膜。The material of the capsule shell is polycarbonate (PC), and the outer surface is coated. The outer surface of the front end 11 is sequentially plated with TiO2 , SiO2 , TiO2 , SiO2 , TiO2 , and SiO2 as shown in Figure 6 to form an anti-reflection film, and then the surface is formed with SiO2 as shown in Figure 4 and Figure 5 after photolithography Micro-nano structure, wherein Fig. 4 is the expanded structure diagram after the outermost layer of the anti-reflection coating of the present invention is formed by photolithography or plasma bombardment to form a micro-nano structure, and Fig. 5 is a view of Fig. 4 from another angle, and finally adopts CF3 (CF2 )5 (CH2 )2 SiCl3 Nano-coating on the outer surface of the SiO2 film to form an anti-adhesive film.
CF3(CF2)5(CH2)2SiCl3具有很好的防粘效果，将CF3(CF2)5(CH2)2SiCl3用于外层镀膜是未来半导体4nm生产技术nanoimprint的核心。CF3(CF2)5(CH2)2SiCl3与SiO2镀膜基材可以在气相或溶液中反应，由于其分子链两端的性能差别，分子层只会在SiO2镀膜基材表面形成单分层子的无毒透明纳米薄层防粘膜。CF3 (CF2 )5 (CH2 )2 SiCl3 has a good anti-adhesive effect, and the use of CF3 (CF2 )5 (CH2 )2 SiCl3 for outer layer coating is the future semiconductor 4nm production technology nanoimprint core. CF3 (CF2 )5 (CH2 )2 SiCl3 and SiO2 coating substrate can react in gas phase or solution. Due to the performance difference at both ends of the molecular chain, the molecular layer will only form a single layer on the surface of SiO2 coating substrate. Layered non-toxic transparent nano-thin layer anti-adhesive film.
本发明提供了一种胶囊状壳体及含有这种胶囊状壳体的胶囊内窥镜，通过在胶囊状壳体不同部位的外表面镀上纳米膜，有效解决了目前检查过程中胶囊状壳体表面易沾染消化道粘液及残渣而导致图像不清晰的问题，能有效降低胶囊内窥镜检查的漏检率。The invention provides a capsule-shaped shell and a capsule endoscope containing the capsule-shaped shell. By coating the outer surfaces of different parts of the capsule-shaped shell with nano-films, it effectively solves the problem of capsule-shaped shells in the current inspection process. The surface of the body is easily contaminated with mucus and residues in the digestive tract, resulting in unclear images, which can effectively reduce the missed detection rate of capsule endoscopy.
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。The above description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention will not be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
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| CN201510137638.4ACN106137760B (en) | 2015-03-26 | 2015-03-26 | Capsule-shaped shell and preparation method, capsule endoscope having the capsule-shaped shell |
| CN201911108970.2ACN110916599B (en) | 2015-03-26 | 2015-03-26 | Capsule-shaped shell and capsule endoscope with capsule-shaped shell |
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| CN201510137638.4ACN106137760B (en) | 2015-03-26 | 2015-03-26 | Capsule-shaped shell and preparation method, capsule endoscope having the capsule-shaped shell |
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| CN201911108970.2ADivisionCN110916599B (en) | 2015-03-26 | 2015-03-26 | Capsule-shaped shell and capsule endoscope with capsule-shaped shell |
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| CN201510137638.4AActiveCN106137760B (en) | 2015-03-26 | 2015-03-26 | Capsule-shaped shell and preparation method, capsule endoscope having the capsule-shaped shell |
| CN201911108970.2AActiveCN110916599B (en) | 2015-03-26 | 2015-03-26 | Capsule-shaped shell and capsule endoscope with capsule-shaped shell |
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| CN201911108970.2AActiveCN110916599B (en) | 2015-03-26 | 2015-03-26 | Capsule-shaped shell and capsule endoscope with capsule-shaped shell |
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