技术领域technical field
本发明涉及贴附于皮肤的皮肤遮蔽材料。The present invention relates to a skin masking material attached to the skin.
背景技术Background technique
面部等的皮肤产生痣、斑等异质部分的人期望隐藏异质部分而不被他人看见。因此，一直以来使用粉底、遮瑕膏等化妆品遮盖异质部分并上妆。但是，化妆品接触汗时会流落，接触手、物体时会剥落，无法十分放心地遮盖异质部分。People who have heterogeneous parts such as moles and spots on the skin of the face want to hide the heterogeneous parts from being seen by others. Therefore, cosmetics such as foundation and concealer have been used to cover the uneven parts and put on makeup. However, cosmetics run off when exposed to sweat, and peel off when touched by hands or objects, making it impossible to cover foreign parts with confidence.
对此，专利文献1公开了一种皮肤遮蔽材料，其在薄膜层的一面层叠有粘合剂层，并在前述薄膜层的另一面形成有微细的凹凸。将专利文献1记载的皮肤遮蔽材料粘贴于异质部分时，异质部分被遮盖而隐藏。进而，在贴附后的该皮肤遮蔽材料上涂布化妆品时，化妆品中包含的粉末附着于另一面，能够使该皮肤遮蔽材料不显眼。In contrast, Patent Document 1 discloses a skin masking material in which an adhesive layer is laminated on one side of a film layer and fine unevenness is formed on the other side of the film layer. When the skin masking material described in Patent Document 1 is pasted on the heterogeneous part, the heterogeneous part is covered and hidden. Furthermore, when cosmetics are applied to the attached skin masking material, the powder contained in the cosmetic material adheres to the other side, and the skin masking material can be made inconspicuous.
现有技术文献prior art literature
专利文献patent documents
专利文献1：日本特开平10-23923号公报Patent Document 1: Japanese Patent Application Laid-Open No. 10-23923
发明内容Contents of the invention
发明要解决的问题The problem to be solved by the invention
但是，可以认为：即使在专利文献1中记载的皮肤遮蔽材料的另一面涂布化妆品，化妆品中包含的粉末大多也会从另一面滑落。另外，可以认为：即使在该另一面重复涂布化妆品至一定程度的厚度，在手、物体碰触时，妆也会立即剥落，完全无法将化妆品保持为稳定状态。上妆性差时，使用者无法通过化妆来调整另一面的颜色以使其与肤色保持一致，掉妆的痕迹明显。However, it is considered that even if cosmetics are applied to the other side of the skin masking material described in Patent Document 1, the powder contained in the cosmetics often slips off from the other side. In addition, it is considered that even if the cosmetic is repeatedly applied to a certain thickness on the other side, the makeup will immediately peel off when touched by a hand or an object, and the cosmetic cannot be kept in a stable state at all. When the makeup is poor, the user cannot adjust the color of the other side through makeup to keep it consistent with the skin tone, and the traces of makeup falling off are obvious.
因而，本发明提供皮肤遮蔽材料，其是在皮肤产生认为是外观异常的部位时为了隐藏该部位而贴附于皮肤的皮肤遮蔽材料，在已贴附的该皮肤遮蔽材料的表面进一步涂抹化妆品时，上妆性良好。Therefore, the present invention provides a skin-masking material that is attached to the skin in order to hide a site that is considered to have an abnormal appearance in the skin, and when cosmetics are further applied to the surface of the skin-masking material that has been attached. , Good makeup application.
用于解决问题的方案solutions to problems
本发明人针对皮肤遮蔽材料的上妆性进行了如下研究。粉底、遮瑕膏之类的化妆品因其种类不同，其粉末的平均粒径在0.1～60μm左右的范围内明显不同。可以认为：根据平均粒径的尺寸，适于保持粉末的凹凸的高低差尺寸是不同的。但是，专利文献1并未研究化妆品中包含的粉末的粒径尺寸、形成于另一面的凹凸的高低差尺寸。可以认为：即使使用专利文献1记载的皮肤遮蔽材料，由于形成于另一面的凹凸的高低差小，因此，化妆品中包含的粉末未被另一面充分保持，上妆性差。The inventors of the present invention conducted the following studies on the makeup application properties of skin masking materials. Cosmetics such as foundations and concealers have significantly different powder average particle diameters in the range of about 0.1 to 60 μm depending on the type. It is considered that the size of the unevenness suitable for holding the powder differs depending on the size of the average particle diameter. However, Patent Document 1 does not study the particle size of the powder contained in the cosmetic and the size of the unevenness formed on the other surface. It is considered that even if the skin masking material described in Patent Document 1 is used, since the unevenness formed on the other surface has a small level difference, the powder contained in cosmetics is not sufficiently held by the other surface, resulting in poor makeup application.
本发明人基于皮肤遮蔽材料的上妆性的好坏取决于在该另一面形成的凹凸的高低差尺寸与化妆品中包含的粉末的粒径尺寸的比率的想法，使用了另一面的微观不平度十点高度Rz大至化妆品中包含的粉末的平均粒径以上的皮肤遮蔽材料。结果发现：与另一面的Rz低于平均粒径的情况相比，能够提供上妆性显著优异的皮肤遮蔽材料。The present inventors used the microscopic roughness of the other side based on the idea that the makeup application performance of the skin masking material depends on the ratio of the size of the unevenness formed on the other side to the particle size of the powder contained in the cosmetics. The ten-point height Rz is as large as the average particle diameter of the powder contained in the cosmetics and is a skin covering material. As a result, it was found that it was possible to provide a skin-masking material that was remarkably excellent in makeup application properties compared to the case where Rz on the other side was lower than the average particle diameter.
即，为了实现前述目的，本发明的皮肤遮蔽材料在具有伸缩性的薄膜层的一面的至少一部分层叠有粘合剂层，将涂布于前述薄膜层的另一面的化妆品中包含的粉末的平均粒径记作d、将该薄膜层的厚度记作w时，前述另一面的微观不平度十点高度Rz满足d≤Rz≤60d、且Rz≤w。That is, in order to achieve the aforementioned object, the skin masking material of the present invention has an adhesive layer laminated on at least a part of one side of the stretchable film layer, and the average amount of the powder contained in the cosmetics coated on the other side of the film layer is When the particle size is denoted as d, and the thickness of the thin film layer is denoted as w, the ten-point height Rz of the microscopic roughness on the other surface satisfies d≤Rz≤60d, and Rz≤w.
或者，本发明的皮肤遮蔽材料在具有伸缩性的薄膜层的一面的至少一部分层叠有粘合剂层，将前述薄膜层的厚度记作w时，该薄膜层的另一面的微观不平度十点高度Rz为6μm≤Rz≤40μm、且Rz≤w。Alternatively, in the skin masking material of the present invention, an adhesive layer is laminated on at least a part of one side of a stretchable film layer, and when the thickness of the film layer is denoted by w, the microscopic unevenness of the other side of the film layer is 10 points. The height Rz is 6 μm≦Rz≦40 μm, and Rz≦w.
另外，可以以前述薄膜层的总光线透射率达到75～90％的方式在该薄膜层内分散微粒。In addition, fine particles may be dispersed in the thin film layer so that the total light transmittance of the thin film layer becomes 75 to 90%.
透湿度可以为400g/(m2·天)以上。The moisture permeability may be 400 g/(m2 ·day) or more.
前述粘合剂层可以包含10～50重量％的在常温下为液体且具有极性基团的有机化合物。The pressure-sensitive adhesive layer may contain 10 to 50% by weight of an organic compound that is liquid at normal temperature and has a polar group.
前述粘合剂层可以包含针对皮肤的药效成分。The aforementioned adhesive layer may contain a medicinal ingredient for the skin.
前述药效成分可以包含选自由α-羟基酸类、水杨酸和它们的混合物组成的组中的化合物。The foregoing medically effective ingredient may contain a compound selected from the group consisting of α-hydroxy acids, salicylic acid, and mixtures thereof.
前述药效成分可以包含抗菌剂。The aforementioned medically effective ingredients may contain an antibacterial agent.
前述抗菌剂可以包含选自由异丙基甲基苯酚、银系抗菌剂和它们的混合物组成的组中的化合物。The aforementioned antibacterial agent may contain a compound selected from the group consisting of isopropylmethylphenol, silver-based antibacterial agents, and mixtures thereof.
前述药效成分可以包含非类固醇抗炎药。The aforementioned medicinal ingredients may contain non-steroidal anti-inflammatory drugs.
前述薄膜层的原材料可以为聚醚聚氨酯或聚酯聚氨酯。The raw material of the aforementioned film layer may be polyether polyurethane or polyester polyurethane.
前述薄膜层的厚度w可以满足6μm≤w≤100μm。The thickness w of the aforementioned thin film layer may satisfy 6 μm≦w≦100 μm.
发明的效果The effect of the invention
根据包括上述技术方案的本发明的皮肤遮蔽材料，在另一面的微观不平度十点高度Rz满足d≤Rz≤60d时，由于形成于另一面的凹凸的高低差大至化妆品中包含的粉末的平均粒径d以上，因此，粉末大多进入凹凸中的凹部内，并保持在凹部内。进而，在该情况下，另一面的Rz为平均粒径d的60倍以下的尺寸，因此，使用者能够拭去进入凹部内的粉末。此时，使用者能够调整涂布于另一面的化妆品的量，因此，能够在避免妆容较厚的同时，进行微调以使另一面的色调与肤色保持一致。According to the skin masking material of the present invention including the above-mentioned technical solution, when the ten-point height Rz of the microscopic unevenness on the other side satisfies d≤Rz≤60d, the level difference of the unevenness formed on the other side is as large as that of the powder contained in the cosmetics. Since the average particle size d is greater than or equal to d, the powder mostly enters the concave portions of the unevenness and remains in the concave portions. Furthermore, in this case, Rz on the other surface is 60 times or less the average particle diameter d, so that the user can wipe off the powder that entered the concave portion. At this time, since the user can adjust the amount of cosmetics applied to the other side, it is possible to make fine adjustments so that the color tone of the other side matches the skin tone while avoiding thick makeup.
或者，根据本发明的皮肤遮蔽材料，在另一面的微观不平度十点高度Rz满足6μm≤Rz≤40μm时，与以往的皮肤遮蔽材料相比，形成于另一面的凹凸的高低差大，化妆品中包含的粉末容易保持在凹部内。进而，在该情况下，另一面的Rz满足Rz≤40μm，因此，凹凸的高低差不会过大，极其容易拭去保持在凹部内的粉末。此时，使用者可容易地补妆，因此，无需慎重地调整颜色亦可。Or, according to the skin masking material of the present invention, when the ten-point height Rz of the microscopic roughness on the other side satisfies 6 μm≤Rz≤40 μm, compared with the conventional skin masking material, the level difference of the unevenness formed on the other side is large, and cosmetics The powder contained in is easily held in the recess. Furthermore, in this case, Rz on the other surface satisfies Rz≦40 μm, so that the unevenness does not become too large, and it is extremely easy to wipe off the powder held in the concave portion. In this case, since the user can easily touch up makeup, it is not necessary to carefully adjust the color.
因此，根据本发明能够提供皮肤遮蔽材料，其是在皮肤产生认为是外观异常的部位时为了隐藏该部位而贴附于皮肤的皮肤遮蔽材料，在已贴附的该皮肤遮蔽材料的表面进一步涂抹化妆品时，上妆性良好。Therefore, according to the present invention, it is possible to provide a skin-masking material that is attached to the skin in order to hide a site that is considered to be abnormal in appearance when the skin has an abnormal appearance, and is further applied to the surface of the skin-masking material that has been attached. For cosmetics, the make-up property is good.
附图说明Description of drawings
图1是示出实施方式1、2的皮肤遮蔽材料的截面图。FIG. 1 is a cross-sectional view showing a skin masking material according to Embodiments 1 and 2. As shown in FIG.
图2是示出以层叠有氨酯薄膜和疏水性薄膜的复合薄膜作为薄膜层的原材料时的其它实施方式的皮肤遮蔽材料的截面图。Fig. 2 is a cross-sectional view showing a skin masking material according to another embodiment when a composite film in which a urethane film and a hydrophobic film are laminated is used as a raw material of the film layer.
图3是示出以层叠有具有凹凸的薄膜和红色薄膜的复合薄膜作为薄膜层的原材料时的其它实施方式的皮肤遮蔽材料的截面图。3 is a cross-sectional view showing a skin masking material of another embodiment when a composite film in which a film having unevenness and a red film is laminated is used as a raw material of the film layer.
图4是示出层叠有粘合剂保护部和凹凸保护部时的其它实施方式的皮肤遮蔽材料的截面图。Fig. 4 is a cross-sectional view showing a skin masking material of another embodiment in which an adhesive protection part and an unevenness protection part are laminated.
图5的(a)是示出在薄膜层的一面的中央部设置有不层叠粘合剂层的部分时的其它实施方式的皮肤遮蔽材料的截面图，图5的(b)是示出在薄膜层的一面的中央部设置有不层叠粘合剂层的部分和格子状粘合剂层时的其它实施方式的皮肤遮蔽材料的截面图，图5的(c)是从粘合剂层的接触皮肤的一侧观察(b)所示的皮肤遮蔽材料时的主视图。(a) of FIG. 5 is a cross-sectional view showing a skin masking material of another embodiment when a portion not laminated with an adhesive layer is provided at the center of one side of the film layer, and (b) of FIG. A cross-sectional view of the skin masking material of another embodiment when the central portion of one side of the film layer is provided with a portion not laminated with an adhesive layer and a grid-shaped adhesive layer. FIG. 5(c) is a view from the adhesive layer A front view when the skin masking material shown in (b) is seen from the side in contact with the skin.
具体实施方式detailed description
[实施方式1][Embodiment 1]
如图1所示那样，实施方式1的皮肤遮蔽材料2a是具备薄膜层4a和粘合剂层6a的层叠体14。粘合剂层6a层叠于薄膜层4a的一面12。As shown in FIG. 1, the skin masking material 2a of Embodiment 1 is the laminated body 14 provided with the film layer 4a and the adhesive layer 6a. The adhesive layer 6a is laminated on one side 12 of the film layer 4a.
薄膜层4a具有伸缩性。将皮肤遮蔽材料2a粘贴于皮肤时，薄膜层4a的至少一部分追随皮肤的曲面而呈现拉伸了的状态。皮肤遮蔽材料2a能够以粘合剂层6a的一面12的对侧的皮肤接触面16整体密合于曲面状皮肤的方式进行贴附。The film layer 4a has stretchability. When the skin masking material 2a is attached to the skin, at least a part of the film layer 4a is stretched following the curved surface of the skin. The skin masking material 2a can be attached so that the entire skin-contacting surface 16 opposite to the one surface 12 of the adhesive layer 6a closely adheres to the curved skin.
为了使薄膜层4a具有伸缩性，优选将拉伸弹性模量为0.2～5MPa的薄膜用作薄膜层4a的原材料。拉伸弹性模量低于0.2MPa时，薄膜层4a会伸缩至必要程度以上，因此，难以用指尖摘取皮肤遮蔽材料2a并从皮肤上剥离。拉伸弹性模量超过5MPa时，薄膜层4a不会追随于皮肤的曲面，因此，皮肤遮蔽材料2a粘贴于皮肤后有可能在短时间内从皮肤剥离。另外，超过5MPa时，粘贴皮肤遮蔽材料2a后，使用者会感到皮肤紧绷，因此，使用者会产生不舒服感。In order to impart stretchability to the film layer 4a, a film having a tensile modulus of 0.2 to 5 MPa is preferably used as a raw material of the film layer 4a. When the tensile modulus is less than 0.2 MPa, the film layer 4a expands and contracts more than necessary, making it difficult to pick and peel the skin masking material 2a from the skin with fingertips. When the tensile elastic modulus exceeds 5 MPa, the film layer 4a does not follow the curved surface of the skin, and therefore, the skin masking material 2a may be peeled off from the skin in a short time after being attached to the skin. In addition, if it exceeds 5 MPa, the user will feel that the skin is tight after sticking the skin masking material 2a, so the user will feel uncomfortable.
薄膜的拉伸弹性模量值通过以下方法测定。The tensile elastic modulus value of the film was measured by the following method.
(1)测定在氮气气氛中以35℃进行。对试样薄膜施加10分钟的初始载重1mN，试样温度保持与气氛温度平衡。(1) The measurement was performed at 35°C in a nitrogen atmosphere. An initial load of 1 mN was applied to the sample film for 10 minutes, and the temperature of the sample was kept in equilibrium with the temperature of the atmosphere.
(2)使试样以100mm/分钟的拉伸速度进行伸长直至载重达到30kPa。(2) The sample is elongated at a tensile speed of 100 mm/min until the load reaches 30 kPa.
(3)在载重为30kPa的状态下，使试样发生蠕变。(3) The sample is allowed to creep under a load of 30 kPa.
(4)将施加10分钟的初始载重1mN时的试样长度(卡盘间距离)记作L0，将载重达到30kPa时的试样长度记作L30。并且，使用如下数学式求出E值。(4) Let L0 be the sample length (distance between chucks) when an initial load of 1 mN is applied for 10 minutes, and let L30 be the sample length when the load reaches 30 kPa. And, E value was calculated|required using the following mathematical formula.
E＝W×L0/(L30-L0)E=W×L0/(L30-L0)
此处，W的值为30kPa。将根据上述数学式算出的E值记作拉伸弹性模量的值。Here, the value of W is 30kPa. Let the E value calculated by the said mathematical formula be the value of tensile elastic modulus.
作为薄膜层4a的原材料，可列举出氨酯树脂系薄膜、醋酸乙烯酯系薄膜、丙烯酸类树脂系薄膜、有机硅树脂系薄膜。作为丙烯酸类树脂系薄膜，可列举出由如下共聚物形成的薄膜，所述共聚物以烷基的碳数为1～8的丙烯酸烷基酯和甲基丙烯酸烷基酯作为主要成分，并包含能够与它们共聚且具有氢键合能力的聚合性单体或预聚物，包含0～20摩尔％的聚合单元。例如，作为丙烯酸类树脂系薄膜，可列举出丙烯酸羟乙基酯(HEA)等丙烯酸羟基烷基酯、羟基乙基丙烯酰胺(HEAA)等具有羟基的丙烯酰胺。Examples of the raw material of the film layer 4 a include urethane resin-based films, vinyl acetate-based films, acrylic resin-based films, and silicone resin-based films. Examples of the acrylic resin film include a film formed of a copolymer containing an alkyl acrylate and an alkyl methacrylate having 1 to 8 carbon atoms in the alkyl group as main components, and containing The polymerizable monomer or prepolymer capable of copolymerizing with these and having hydrogen bonding ability contains 0 to 20 mol% of polymerized units. For example, examples of the acrylic resin film include hydroxyalkyl acrylates such as hydroxyethyl acrylate (HEA), and acrylamides having a hydroxyl group such as hydroxyethylacrylamide (HEAA).
此处，作为甲基丙烯酸烷基酯，可例示出甲基丙烯酸甲酯。进而，此处作为丙烯酸烷基酯，可例示出丙烯酸乙酯。甲基丙烯酸甲酯与丙烯酸乙酯的摩尔比例如为40:90～40:180。将它们共聚而成的丙烯酸类树脂系薄膜在其表面平滑且其厚度为30μm的情况下，透湿度达到900～1,300g/(m2·天)。Here, methyl methacrylate can be illustrated as an alkyl methacrylate. Furthermore, ethyl acrylate can be illustrated here as an alkyl acrylate. The molar ratio of methyl methacrylate to ethyl acrylate is, for example, 40:90 to 40:180. The acrylic resin film obtained by copolymerizing these has a moisture permeability of 900 to 1,300 g/(m2 ·day) when the surface is smooth and the thickness is 30 μm.
或者，此处作为丙烯酸烷基酯，可例示出丙烯酸丁酯。甲基丙烯酸甲酯与丙烯酸丁酯的摩尔比例如为10:16～10:25。将它们共聚而成的丙烯酸类树脂系薄膜在其表面平滑且其厚度为30μm的情况下，透湿度达到900g/(m2·天)左右。Alternatively, butyl acrylate can be exemplified here as the alkyl acrylate. The molar ratio of methyl methacrylate to butyl acrylate is, for example, 10:16 to 10:25. The acrylic resin film obtained by copolymerizing these has a moisture permeability of about 900 g/(m2 ·day) when the surface is smooth and the thickness is 30 μm.
作为粘合剂层6a的原材料，可列举出选自由丙烯酸系粘合剂、橡胶系粘合剂、有机硅系粘合剂、氨酯系粘合剂和它们的混合物组成的组中的粘合剂。另外，丙烯酸系粘合剂、有机硅系粘合剂、氨酯系粘合剂的透湿度比橡胶系粘合剂高，因此，优选将选自由丙烯酸系粘合剂、有机硅系粘合剂、氨酯系粘合剂和它们的混合物组成的组中的粘合剂用作粘合剂层6a的原材料来得到透湿度高的皮肤遮蔽材料2a。As the raw material of the adhesive layer 6a, adhesives selected from the group consisting of acrylic adhesives, rubber adhesives, silicone adhesives, urethane adhesives, and mixtures thereof are exemplified. agent. In addition, the moisture permeability of acrylic adhesives, silicone adhesives, and urethane adhesives is higher than that of rubber adhesives. Adhesives in the group consisting of urethane adhesives, urethane adhesives, and mixtures thereof are used as raw materials for the adhesive layer 6a to obtain the skin masking material 2a with high moisture permeability.
粘合剂层6a的原材料进一步优选为丙烯酸系粘合剂。使用丙烯酸系粘合剂时，可通过单体的组合来调整粘合剂层6a的透湿度。例如，将选自由羟基乙基丙烯酰胺(HEAA)、丙烯酸烷氧基烷基酯、醋酸乙烯酯(VA)和它们的混合物组成的组中的单体的共聚物用作粘合剂的原料时，粘合剂层6a的透湿度变高。另外，使用丙烯酸系粘合剂时，能够将粘合剂层6a制成凝胶状。粘合剂层6a为凝胶状时，将皮肤遮蔽材料2a贴附于皮肤时、从皮肤上剥离时，能够抑制角质的损伤。丙烯酸系粘合剂为高分子量体且具有粘合性，因此使用丙烯酸系粘合剂时，粘合剂层6a基本不含可成为过敏的原因物质的分子量1,000以下的低分子量添加物。The raw material of the adhesive layer 6a is more preferably an acrylic adhesive. When an acrylic adhesive is used, the moisture permeability of the adhesive layer 6a can be adjusted by combining monomers. For example, when a copolymer of monomers selected from the group consisting of hydroxyethylacrylamide (HEAA), alkoxyalkyl acrylate, vinyl acetate (VA) and mixtures thereof is used as a raw material for the adhesive , the moisture permeability of the adhesive layer 6a becomes high. In addition, when an acrylic adhesive is used, the adhesive layer 6a can be made into a gel form. When the adhesive layer 6a is in the form of a gel, damage to the keratin can be suppressed when the skin masking material 2a is attached to the skin or when it is peeled off from the skin. Since the acrylic adhesive is high molecular weight and has adhesiveness, when an acrylic adhesive is used, the adhesive layer 6a does not substantially contain low-molecular-weight additives with a molecular weight of 1,000 or less that may cause allergies.
粘合剂层6a的厚度优选为10～30μm。厚度低于10μm时，根据成为粘合剂层6a的原材料的粘合剂种类的不同，皮肤遮蔽材料2a对皮肤不具有规定的粘合力。厚度超过30μm时，粘贴皮肤遮蔽材料2a后，不仅化妆品有可能附着于粘合剂层6a的边缘部分而导致边界变得显眼，还可能成为皮肤遮蔽材料2a挂住手指、衣服而剥落的原因。另外，超过30μm时，根据成为原材料的粘合剂种类的不同，难以使粘合剂层6a具备充分的透湿性。The thickness of the adhesive layer 6 a is preferably 10 to 30 μm. When the thickness is less than 10 μm, the skin masking material 2a does not have a predetermined adhesive force to the skin depending on the type of adhesive used as the raw material of the adhesive layer 6a. If the thickness exceeds 30 μm, after sticking the skin masking material 2a, not only the cosmetics may adhere to the edge of the adhesive layer 6a to make the border conspicuous, but also the skin masking material 2a may catch fingers and clothes and peel off. Moreover, when it exceeds 30 micrometers, it becomes difficult to provide the adhesive layer 6a with sufficient moisture permeability depending on the kind of adhesive used as a raw material.
粘合剂层6a的粘合力是根据基于JIS K 6854-2的粘接剂的剥离粘接强度试验方法的180度剥离而测定的值，皮肤遮蔽材料2在SUS板上的粘合力优选为0.1～10(N/25mm)。粘合力低于0.1N/25mm时，粘合力太弱，因此，皮肤遮蔽材料2a有可能在短时间内从皮肤上剥离。粘合力超过10N/25mm时，粘合力太强，因此，将皮肤遮蔽材料2a从皮肤上剥离时，有可能刺激皮肤而使角质损伤。The adhesive force of the adhesive layer 6a is a value measured by 180-degree peeling according to the peel adhesive strength test method of an adhesive based on JIS K 6854-2, and the adhesive force of the skin masking material 2 on the SUS board is preferably 0.1 to 10 (N/25mm). When the adhesive force is less than 0.1N/25mm, the adhesive force is too weak, and therefore, the skin masking material 2a may be peeled off from the skin in a short time. When the adhesive force exceeds 10N/25mm, the adhesive force is too strong, and therefore, when the skin masking material 2a is peeled off from the skin, the skin may be irritated and the keratin may be damaged.
关于薄膜层4a的另一面10a的微观不平度十点高度Rz，将涂布于薄膜层4a的另一面10a的粉底、遮瑕膏之类的化妆品中包含的粉末的平均粒径记作d时，该Rz为d的1～60倍、即d≤Rz≤60d。另外，将薄膜层4a的厚度记作w时，另一面10的Rz为w以下、即Rz≤w。需要说明的是，另一面10a的Rz是按照JIS B 0601:2001在基准长度500μm、取样长度200μm的条件下使用表面粗糙度测定机测定另一面10a的表面形状而得到的值。Regarding the ten-point height Rz of the microscopic roughness of the other surface 10a of the film layer 4a, when the average particle diameter of the powder contained in the cosmetics such as foundation and concealer coated on the other surface 10a of the film layer 4a is denoted as d, This Rz is 1 to 60 times d, that is, d≤Rz≤60d. In addition, when the thickness of the film layer 4a is expressed as w, Rz of the other surface 10 is w or less, that is, Rz≦w. It should be noted that Rz of the other surface 10a is a value obtained by measuring the surface shape of the other surface 10a using a surface roughness measuring machine under the conditions of a reference length of 500 μm and a sampling length of 200 μm in accordance with JIS B 0601:2001.
化妆品中包含的粉末的平均粒径d是按照JIS Z 8825-1:2001利用粒径分析·激光衍射法测定的以体积基准粒度分布计的累积值为50％的粒径、即中值粒径。The average particle size d of powder contained in cosmetics is the particle size at which the cumulative value of the volume-based particle size distribution is 50% measured by particle size analysis and laser diffraction method in accordance with JIS Z 8825-1:2001, that is, the median particle size .
粉底、遮瑕膏之类的化妆品中包含的颗粒的平均粒径d存在0.1μm≤d≤60μm左右的幅度。与此相对，另一面10a的Rz为d的1倍～60倍。另一面10a的Rz大至平均粒径d以上，因此，化妆品中包含的粉末大多进入形成于另一面10a的凹凸中的凹部内，并保持在凹部内。可以认为：在另一面10a涂布化妆品时，粉末被挤进凹部内，由于薄膜层4a具有伸缩性，因此凹部配合着粉末形状而伸缩，即使另一面10a的Rz为d的1倍或接近1倍的尺寸，粉末的大部分也会进入并保持在凹部内。进而，另一面10a的Rz为平均粒径d的60倍以下的尺寸，因此，使用者能够拭去进入凹部内的粉末。使用者能够调整涂布至另一面10a的化妆品量，因此，能够在避免妆容较厚的同时，进行微调以使另一面10a的色调与肤色保持一致。The average particle diameter d of particles contained in cosmetics such as foundation and concealer has a range of about 0.1 μm≤d≤60 μm. On the other hand, Rz of the other surface 10 a is 1 to 60 times d. Since Rz of the other surface 10a is as large as the average particle diameter d or more, most of the powder contained in the cosmetic enters into the recesses formed in the unevenness of the other face 10a and is held in the recesses. It can be considered that when cosmetics are applied on the other side 10a, the powder is squeezed into the concave portion, and since the film layer 4a has stretchability, the concave portion expands and contracts according to the shape of the powder, even if the Rz of the other side 10a is 1 time or close to 1 d. times the size, most of the powder will also enter and remain in the recess. Furthermore, since Rz of the other surface 10a is 60 times or less the average particle diameter d, the user can wipe off the powder that entered the concave portion. The user can adjust the amount of cosmetics applied to the other surface 10a, and thus can fine-tune the color tone of the other surface 10a to match the skin color while avoiding thick makeup.
形成于薄膜层4a的另一面10a的凹凸的高低差不会超过薄膜层4a的厚度w，因此，另一面10a的Rz为w以下。即使在Rz＝w的状态下，换言之，在形成于另一面10a的凹部是贯穿薄膜层4a的贯穿孔、该贯穿孔的底部露出粘合剂层6a的状态下，也能够将化妆品中包含的粉末保持于另一面10a。Since the unevenness formed on the other surface 10a of the film layer 4a does not exceed the thickness w of the film layer 4a, Rz of the other surface 10a is equal to or less than w. Even under the state of Rz=w, in other words, in the state where the concave portion formed on the other surface 10a is a through hole penetrating the film layer 4a, and the bottom of the through hole exposes the adhesive layer 6a, the cosmetics contained The powder is held on the other side 10a.
通过上述的构成和作用，皮肤遮蔽材料2a可以在皮肤产生认为是外观异常的部位时为了隐藏该部位而贴附于皮肤，在已贴附的皮肤遮蔽材料2a的表面进一步涂抹化妆品时，上妆性良好。Through the above-mentioned structure and function, the skin masking material 2a can be attached to the skin in order to hide the part when the skin has a part that is considered to be abnormal in appearance. sex is good.
目前制造了在表面施加了压花加工的氨酯薄膜，但其表面性状是：算术平均粗糙度Ra低于0.3μm，Rz约为1μm以下。即使在以往的氨酯薄膜的表面涂布平均粒径d处于2～60μm范围的粉末，粉末也会从薄膜表面滑落。Currently, urethane films embossed on the surface are produced, but the surface properties thereof are such that the arithmetic mean roughness Ra is less than 0.3 μm, and Rz is approximately 1 μm or less. Even if a powder having an average particle diameter d in the range of 2 to 60 μm is coated on the surface of a conventional urethane film, the powder slips off the surface of the film.
与此相对，皮肤遮蔽材料2a的另一面10a的Rz为d≤Rz≤60d，因此，即使在化妆品中包含的粉末的平均粒径d处于2～60μm范围的情况下，上妆性也良好。需要说明的是，关于另一面10a的Rz，在d为2μm的情况下，2μm≤Rz≤120μm、且Rz≤w。在d为6μm的情况下，6μm≤Rz≤360μm、且Rz≤w。在d为60μm的情况下，60μm≤Rz≤3,600μm、且Rz≤w。On the other hand, Rz of the other surface 10a of the skin masking material 2a satisfies d≤Rz≤60d, so even when the average particle diameter d of the powder contained in the cosmetic is in the range of 2 to 60 μm, the makeup application property is good. In addition, regarding Rz of the other surface 10a, when d is 2 micrometers, 2 micrometers≤Rz≤120 micrometers, and Rz≤w. When d is 6 μm, 6 μm≦Rz≦360 μm, and Rz≦w. When d is 60 μm, 60 μm≦Rz≦3,600 μm, and Rz≦w.
[实施方式2][Embodiment 2]
本说明书中，各图中示出的相同符号表示同一或相同的构件。关于图1所示的实施方式2的皮肤遮蔽材料2b，针对与皮肤遮蔽材料2a不同的构成和作用效果进行说明。皮肤遮蔽材料2b的另一面10b的Rz为6μm≤Rz≤40μm，且Rz≤w。In this specification, the same code|symbol shown in each drawing represents the same or the same member. Regarding the skin-shielding material 2b of Embodiment 2 shown in FIG. 1, the configuration and operation effect different from the skin-shielding material 2a will be described. The Rz of the other surface 10b of the skin masking material 2b is 6 μm≤Rz≤40 μm, and Rz≤w.
与以往的皮肤遮蔽材料相比，皮肤遮蔽材料2b的形成于其另一面10b的凹凸的高低差较大，化妆品中包含的粉末容易保持在凹部内。进而，皮肤遮蔽材料2b的另一面10b的Rz为Rz≤40μm，因此，凹凸的高低差不会过大，极其容易拭去保持在凹部内的粉末。使用者可容易地补妆，因此，无需慎重地调整颜色亦可。Compared with the conventional skin masking material, the skin masking material 2b has a larger unevenness formed on the other surface 10b, and the powder contained in cosmetics is easily retained in the concave portion. Furthermore, the Rz of the other surface 10b of the skin masking material 2b is Rz≦40μm, so the level difference of the unevenness will not be too large, and it is extremely easy to wipe off the powder held in the concave portion. The user can easily touch up the makeup, so there is no need to carefully adjust the color.
另一面10b的Rz优选为10μm≤Rz≤40μm、且Rz≤w。在另一面10b涂布多种遮瑕膏、粉底之类的化妆品时，形成于另一面10b的凹凸中的凹部内会保持平均粒径d各不相同的多种粉末。与6μm≤Rz＜10μm的情况相比，10μm≤Rz≤40μm时，凹凸的高低差充分大，因此，连涂布在遮瑕膏的粉末上的粉底的粉末也能够充分保持。Rz of the other surface 10b is preferably 10 μm≦Rz≦40 μm, and Rz≦w. When various cosmetics such as concealer and foundation are applied to the other surface 10b, various types of powders having different average particle diameters d are retained in the recesses formed in the unevenness of the other surface 10b. Compared with the case of 6 μm ≤ Rz < 10 μm, when 10 μm ≤ Rz ≤ 40 μm, the difference in height of the unevenness is sufficiently large, so that the powder of the foundation coated on the powder of the concealer can be sufficiently retained.
另一面10的Rz进一步优选为17μm≤Rz≤35μm、且Rz≤w。与10μm≤Rz＜17μm的情况相比，17μm≤Rz≤35μm时，凹凸内可保持大量粉末，因此，涂布多种化妆品时，上妆性特别良好。另外，与35μm＜Rz≤40μm的情况相比，17μm≤Rz≤35μm时，凹凸的高低差尺寸接近于皮肤表面存在的凹凸的高低差，使用者能够以近似于从肌肤上拭去化妆品时的感觉从另一面10b拭去化妆品。Rz of the other surface 10 is more preferably 17 μm≦Rz≦35 μm, and Rz≦w. Compared with the case of 10 μm ≤ Rz < 17 μm, when 17 μm ≤ Rz ≤ 35 μm, a large amount of powder can be retained in the unevenness, so when applying various cosmetics, the makeup application property is particularly good. In addition, compared with the case of 35 μm < Rz ≤ 40 μm, when 17 μm ≤ Rz ≤ 35 μm, the size of the unevenness is close to that of the unevenness existing on the skin surface, and the user can wipe off the cosmetics from the skin in a similar manner. Make-up is felt to be wiped off from the other side 10b.
需要说明的是，对于皮肤遮蔽材料2b而言，相对于涂布于另一面10b的化妆品中包含的粉末的平均粒径d，另一面10b的Rz为d≤Rz≤60d时，可发挥出上妆性良好的效果。另一面10b的Rz为6μm≤Rz≤40μm、且Rz≤w时，会发挥出上妆性良好的效果的粉末的平均粒径d的最大范围为0.1μm≤d≤40μm、且d≤w。另一面10b的Rz为6μm≤Rz≤40μm、且Rz≤w时，会发挥出上妆性良好的效果的粉末的平均粒径d的最大范围约为0.17μm≤d≤40μm、且d≤w。另一面10b的Rz为17μm≤Rz≤35μm、且Rz≤w时，会发挥出上妆性良好的效果的粉末的平均粒径d的最大范围约为0.28μm≤d≤35μm、且d≤w。It should be noted that, for the skin masking material 2b, with respect to the average particle diameter d of the powder contained in the cosmetics applied to the other surface 10b, when the Rz of the other surface 10b is d≤Rz≤60d, the above characteristics can be exhibited. Good makeup effect. When Rz of the other surface 10b is 6 μm≤Rz≤40 μm and Rz≤w, the maximum range of the average particle diameter d of the powder exhibiting a good makeup application effect is 0.1 μm≤d≤40 μm and d≤w. When the Rz of the other surface 10b is 6 μm≤Rz≤40 μm and Rz≤w, the maximum range of the average particle diameter d of the powder exhibiting a good makeup application effect is about 0.17 μm≤d≤40 μm and d≤w . When the Rz of the other surface 10b is 17 μm≤Rz≤35 μm and Rz≤w, the maximum range of the average particle diameter d of the powder exhibiting a good makeup application effect is about 0.28 μm≤d≤35 μm and d≤w .
关于另一面(10a、10b)，将涂布于另一面(10a、10b)的遮瑕膏、粉底之类的化妆品中包含的粉末的平均粒径记作d，将薄膜层4a的厚度记作w时，另一面(10a、10b)的按照JISB 0601:2001定义的算术平均粗糙度Ra优选为0.15d≤Ra≤3d、且Ra≤(w/2)。具体而言，d为2μm时，0.3μm≤Ra≤6μm、且Ra≤(w/2)。另外，d为6μm时，0.9μm≤Ra≤18μm、且Ra≤(w/2)。另一面(10a、10b)若为这种表面性状，则在保持化妆品中包含的粉末的方面是适合的。With regard to the other surface (10a, 10b), the average particle diameter of the powder contained in the cosmetics such as concealer and foundation applied to the other surface (10a, 10b) is denoted as d, and the thickness of the film layer 4a is denoted as w , the arithmetic average roughness Ra defined in JISB 0601:2001 of the other surface (10a, 10b) is preferably 0.15d≤Ra≤3d, and Ra≤(w/2). Specifically, when d is 2 μm, 0.3 μm≦Ra≦6 μm, and Ra≦(w/2). In addition, when d is 6 μm, 0.9 μm≦Ra≦18 μm, and Ra≦(w/2). If the other surface (10a, 10b) has such a surface texture, it is suitable for holding powder contained in cosmetics.
形成于另一面(10a、10b)的凹凸中的凹部可以是选自由大致圆柱形的孔状、大致棱柱形的孔状、大致研钵形的孔状、槽状、以及这些形状混合存在的形状组成的组中的形状。关于形成于另一面(10a、10b)的凹部的深度、凸部的高度，每个凹部、每个凸部均可以不同。通过分别调整并设置多个凹部、凸部的配置、凹部的深度、凸部的高度，可以在另一面(10a、10b)以形成几何学花纹的方式设置凹凸。在另一面(10a、10b)形成有这种凹凸时，与平滑的情况相比，射入薄膜层4a的光因凹凸而折射或漫反射而扩散，因此，皮肤遮蔽材料(2a、2b)的遮蔽性高。另外，出于相同的原因，若另一面(10a、10b)的Rz大，则薄膜层4a的总光线透射率低、皮肤遮蔽材料(2a、2b)的遮蔽性高。The recess formed in the unevenness of the other surface (10a, 10b) may be a shape selected from a substantially cylindrical hole shape, a substantially prismatic hole shape, a substantially mortar-shaped hole shape, a groove shape, and a mixture of these shapes. Composed of shapes in the set. The depth of the recesses and the height of the protrusions formed on the other surface (10a, 10b) may be different for each recess and each protrusion. By adjusting and providing a plurality of recesses, the arrangement of protrusions, the depth of recesses, and the height of protrusions, irregularities can be provided on the other surface (10a, 10b) to form a geometric pattern. When such unevenness is formed on the other surface (10a, 10b), compared with the smooth case, the light entering the film layer 4a is diffused due to refraction or diffuse reflection due to the unevenness, so the skin masking material (2a, 2b) High shielding. Also, for the same reason, if the Rz of the other surface (10a, 10b) is large, the total light transmittance of the film layer 4a is low, and the shielding property of the skin shielding material (2a, 2b) is high.
形成于另一面(10a、10b)的凹部为孔状时，孔径优选为3～35μm。另外，凹部为槽状时，槽的宽度优选为5～35μm。为这种孔的直径、槽的宽度时，入射光发生折射或扩散，因此，皮肤遮蔽材料(2a、2b)的遮蔽性高，在另一面(10a、10b)涂布多种化妆品的粉末时，上妆性良好。When the concave portion formed on the other surface (10a, 10b) has a hole shape, the hole diameter is preferably 3 to 35 μm. In addition, when the concave portion is in the shape of a groove, the width of the groove is preferably 5 to 35 μm. When the diameter of the hole and the width of the groove are such that the incident light is refracted or diffused, the skin masking material (2a, 2b) has high shielding properties, and when the powder of various cosmetics is coated on the other side (10a, 10b) , Good makeup application.
形成于另一面(10a、10b)的凹凸的形状优选为与天然皮革或人工皮革的表面上设置的凹凸形状类似的形状。为这种形状时，皮肤遮蔽材料(2a、2b)的遮蔽性高，另一面(10a、10b)的上妆性良好，涂布化妆品后，被皮肤遮蔽材料(2a、2b)遮盖的部分与未被遮盖的肌肤部分的外观差异小。The shape of the irregularities formed on the other surface (10a, 10b) is preferably similar to the irregularities provided on the surface of natural leather or artificial leather. In such a shape, the skin masking material (2a, 2b) has high concealment performance, and the other side (10a, 10b) has good makeup application property. After applying cosmetics, the part covered by the skin masking material (2a, 2b) and There is little difference in the appearance of the uncovered parts of the skin.
[皮肤遮蔽材料的制造方法][Manufacturing method of skin masking material]
在具有反转图案的流延用剥离性基板的表面流延树脂溶液并干燥，将干燥物从基板上剥离，得到成为薄膜层4a原材料的薄膜M。在薄膜M的另一面(转印面)转印反转图案，从而形成凹凸。The resin solution is cast and dried on the surface of a release substrate for casting having a reverse pattern, and the dried product is peeled off from the substrate to obtain a film M to be a raw material of the film layer 4a. On the other surface (transfer surface) of the film M, a reverse pattern is transferred to form unevenness.
粘合剂层6a的原材料使用丙烯酸系粘合剂时，将作为粘合剂原料的单体等混合溶解于醋酸乙酯，添加聚合引发剂而使其共聚，添加交联剂来制备流延用溶液。另外，粘合剂层6a的原材料使用有机硅系粘合剂时，使用为将规定的两种溶液混合的方式等的市售的有机硅系粘合剂，制备流延用溶液。粘合剂层6a的原材料使用橡胶系粘合剂时，将作为粘合剂原料的聚合物混合溶解于甲苯，添加软化剂、赋粘剂、抗氧化剂，制备流延用溶液。粘合剂层6a的原材料使用氨酯系粘合剂时，在即将流延之前混合规定的两种溶液来制备流延用溶液。进而，在使用丙烯酸系、有机硅系、橡胶系或氨酯系中的任意粘合剂时，也将流延用溶液流延在剥离片材上，将流延物干燥或加热，从而得到成为粘合剂层6a原材料的粘合剂片材N。When an acrylic adhesive is used as the raw material of the adhesive layer 6a, a monomer for the adhesive raw material is mixed and dissolved in ethyl acetate, a polymerization initiator is added to copolymerize it, and a crosslinking agent is added to prepare a resin for casting. solution. In addition, when a silicone-based adhesive is used as a raw material of the adhesive layer 6a, a commercially available silicone-based adhesive such as a method of mixing two predetermined solutions is used to prepare a solution for casting. When a rubber-based adhesive is used as the raw material of the adhesive layer 6a, a polymer used as an adhesive raw material is mixed and dissolved in toluene, and a softener, a tackifier, and an antioxidant are added to prepare a casting solution. When a urethane-based adhesive is used as a raw material of the adhesive layer 6a, a solution for casting is prepared by mixing two predetermined solutions immediately before casting. Furthermore, when any adhesive of acrylic, silicone, rubber, or urethane is used, the solution for casting is also cast on a release sheet, and the cast product is dried or heated to obtain The adhesive sheet N which is the raw material of the adhesive layer 6a.
将薄膜M的一面(不是转印面的面)载置贴合在粘合剂片材N的不具有剥离片材的面上，得到M和N和剥离片材的层叠物。针对该层叠物，从M的另一面(转印面)侧用刀具冲切成规定形状时，能够得到皮肤遮蔽材料(2a、2b)的皮肤接触面16被剥离片材的切片(剥离纸)遮盖而成的形态。One side of the film M (the side that is not the transfer side) was placed and bonded on the side of the adhesive sheet N that did not have the release sheet to obtain a laminate of M and N and the release sheet. When this laminate is punched into a predetermined shape from the other surface (transfer surface) side of the M, the skin contact surface 16 of the skin masking material (2a, 2b) can be covered by a slice (release paper) of the release sheet. formed form.
需要说明的是，皮肤遮蔽材料(2a、2b)以其皮肤接触面16被剥离纸覆盖的形态作为产品进行流通，使用者在即将贴附于皮肤之前剥掉剥离纸。另外，制造皮肤遮蔽材料(2a、2b)时，例如，通过使用对反转图案的凹凸形状进行加工而改变的基板，能够调整形成于皮肤遮蔽材料(2a、2b)的另一面(10a、10b)的凹凸形状。It should be noted that the skin masking materials (2a, 2b) are distributed as a product in the form that the skin contact surface 16 is covered with release paper, and the user peels off the release paper immediately before sticking to the skin. In addition, when manufacturing the skin-masking materials (2a, 2b), for example, by using a substrate that changes the concavo-convex shape of the reversed pattern by processing, it is possible to adjust the surface area (10a, 10b) formed on the other surface (10a, 10b) of the skin-masking materials (2a, 2b). ) concave-convex shape.
[薄膜层的光线透射率][Light transmittance of film layer]
皮肤遮蔽材料(2a、2b)可以在分散于其薄膜层4a内的状态下包含微粒，以使在基于JIS K 7105:1981的塑料的光学特性试验方法中，使用积分球式光线透射率测定装置测得的薄膜层4a的总光线透射率达到75～90％。另外，皮肤遮蔽材料(2a、2b)可以在分散于其薄膜层4a内的状态下包含微粒，以使在基于JIS K 7105:1981的塑料的光学特性试验方法中，使用积分球式光线透射率测定装置测得的薄膜层4a的平行光线透射率达到0～12％，且薄膜层4a的雾度(雾值)达到84～100％。The skin masking materials (2a, 2b) may contain microparticles in the state of being dispersed in the film layer 4a thereof, so that in the optical characteristic test method of plastics based on JIS K 7105:1981, the light transmittance measuring device of the integrating sphere type is used. The measured total light transmittance of the film layer 4a reaches 75-90%. In addition, the skin masking materials (2a, 2b) may contain fine particles in the state of being dispersed in the film layer 4a thereof, so that in the optical characteristic test method of plastics based on JIS K 7105:1981, the light transmittance of the integrating sphere is used. The parallel light transmittance of the film layer 4a measured by the measuring device reaches 0-12%, and the haze (haze value) of the film layer 4a reaches 84-100%.
薄膜层4a的总光线透射率为75～90％时，入射至薄膜层4a的一部分光被微粒吸收。另外，薄膜层4a的平行光线透射率为0～12％且薄膜层4a的雾度(雾值)为84～100％时，入射至薄膜层4a的大部分光在分散在薄膜层4a内的微粒的表面漫反射而扩散。通过这些作用，将皮肤遮蔽材料(2a、2b)贴附于皮肤的异质部分时，不会隔着皮肤遮蔽材料(2a、2b)清晰地透视出异质部分，能够淡化并隐藏异质部分。进而，在另一面(10a、10b)不会产生油光。此时，在皮肤遮蔽材料(2a、2b)上进一步涂布化妆品时，难以分辨出其与肌肤的其它部分之间的不同，在外观上是优选的。When the total light transmittance of the thin film layer 4a is 75 to 90%, part of the light incident on the thin film layer 4a is absorbed by the fine particles. In addition, when the parallel light transmittance of the film layer 4a is 0 to 12% and the haze (haze value) of the film layer 4a is 84 to 100%, most of the light incident on the film layer 4a is dispersed in the film layer 4a. The surface of the particle diffuses and diffuses. Through these functions, when the skin masking material (2a, 2b) is attached to the heterogeneous part of the skin, the heterogeneous part will not be clearly seen through the skin masking material (2a, 2b), and the heterogeneous part can be diluted and hidden. . Furthermore, there is no shine on the other surface (10a, 10b). In this case, when cosmetics are further applied to the skin masking materials (2a, 2b), it is difficult to distinguish the difference from other parts of the skin, which is preferable in terms of appearance.
薄膜层4a的总光线透射率超过90％时，会隔着皮肤遮蔽材料(2a、2b)透视到应隐藏的部位。薄膜层4a的平行光线透射率超过12％时、薄膜层4a的雾度(雾值)低于84％时，也会透视到应隐藏的部位。另外，薄膜层4a的总光线透射率低于75％时，粘贴有皮肤遮蔽材料(2a、2b)的部分基本反映不出肌肤的颜色，因此，皮肤遮蔽材料(2a、2b)的外观不会融合于周围的皮肤。在皮肤遮蔽材料(2a、2b)上进一步涂布粉底后，相对于周围的皮肤，粘贴有皮肤遮蔽材料(2a、2b)的部分变为不自然的颜色，比较显眼。When the total light transmittance of the film layer 4a exceeds 90%, it can see through the skin masking materials (2a, 2b) to the parts that should be hidden. When the parallel ray transmittance of the thin film layer 4a exceeds 12%, and when the haze (haze value) of the thin film layer 4a is lower than 84%, the portion to be hidden is seen through. In addition, when the total light transmittance of the film layer 4a is lower than 75%, the part where the skin masking material (2a, 2b) is pasted does not reflect the color of the skin substantially, so the appearance of the skin masking material (2a, 2b) will not change. Blends into surrounding skin. After the foundation is further applied to the skin masking materials (2a, 2b), the parts to which the skin masking materials (2a, 2b) are pasted become unnaturally conspicuous compared to the surrounding skin.
薄膜层4a内包含的微粒的粒径p可以为10nm≤p≤20μm、且p≤(w/2)。关于微粒的含量，针对在制造成为薄膜层4a原材料的薄膜时成为原材料的薄膜自身，可以以总光线透射率达到75～90％、平行光线透射率达到0％～12％、且雾度(雾值)达到84～100％的方式进行调整。微粒的含量相对于薄膜重量优选为0.05～30重量％。The particle size p of the fine particles contained in the thin film layer 4 a may be 10 nm≤p≤20 μm, and p≤(w/2). Regarding the content of microparticles, for the film itself that becomes the raw material when the film that becomes the raw material of the film layer 4a is manufactured, the total light transmittance can reach 75-90%, the parallel light transmittance can reach 0%-12%, and the haze (fog) value) to 84 to 100% to adjust. The content of fine particles is preferably 0.05 to 30% by weight relative to the weight of the film.
作为构成微粒的物质，可列举出珍珠系颜料、滑石、云母、二氧化硅、高岭土、粘土、云母粉、石英粉、硅藻土、蒙脱石、蛭石、无定形二氧化硅、二氧化硅-氧化铝、炭黑、铁素体、石墨、树脂粉末、钙、镁、铝、锂、钡、钛等的硅酸盐、硫酸盐、碳酸盐、磷酸盐、铝酸盐、金属氧化物等。这些微粒会吸收入射至薄膜层4a的光或者使其漫反射而扩散。另外，这些微粒是对皮肤等无害的物质。微粒优选由化学稳定的物质构成。Examples of materials constituting fine particles include pearl-based pigments, talc, mica, silica, kaolin, clay, mica powder, quartz powder, diatomaceous earth, montmorillonite, vermiculite, amorphous silica, Silicon-alumina, carbon black, ferrite, graphite, resin powder, silicates, sulfates, carbonates, phosphates, aluminates, metal oxides of calcium, magnesium, aluminum, lithium, barium, titanium, etc. things etc. These fine particles absorb light incident on the thin film layer 4a or diffusely reflect and diffuse it. In addition, these fine particles are harmless to skin and the like. The microparticles preferably consist of chemically stable substances.
成为薄膜层4a原材料的薄膜除了由微粒产生的作用以外，形成于另一面(10a、10b)的凹凸使射入薄膜的光发生折射，因此，总光线透射率达到75～90％、平行光线透射率达到0～12％、且雾度(雾值)达到84～100％。此时，成为薄膜层4a原材料的薄膜可显示如下的透明性：在透过薄膜观察到薄膜对侧存在的物体时，只要是距离薄膜约为1cm以内存在的物体，就能够识别该物体的形状、亮度等，对距离薄膜大于约1cm处存在的物体的形状、亮度等，则无法识别。In addition to the effect of the particles on the film that becomes the raw material of the film layer 4a, the unevenness formed on the other surface (10a, 10b) refracts the light incident on the film, so the total light transmittance reaches 75-90%. The rate reaches 0-12%, and the haze (haze value) reaches 84-100%. At this time, the film used as the raw material of the film layer 4a can exhibit such transparency that when an object existing on the opposite side of the film is observed through the film, as long as the object exists within about 1 cm from the film, the shape of the object can be recognized. , brightness, etc., the shape, brightness, etc. of objects that exist at a distance of more than about 1 cm from the film cannot be recognized.
成为薄膜层4a原材料的薄膜中，除了添加微粒之外，还可以添加染料、颜料。调整染料、颜料的添加量时，可以以容易调和成皮肤颜色的方式调整薄膜层4a的色调。通过这种调整，将皮肤遮蔽材料(2a、2b)贴附在皮肤上并进一步涂布化妆品时，能够减少为了使贴附部位无法与皮肤的其它部位区分而通过化妆来调整颜色的劳力和时间。In addition to fine particles, dyes and pigments may be added to the thin film used as the raw material of the thin film layer 4a. When adjusting the amount of dyes and pigments added, the color tone of the film layer 4a can be adjusted so that it can be easily adjusted to the skin color. Through this adjustment, when the skin masking materials (2a, 2b) are attached to the skin and further cosmetics are applied, labor and time for adjusting the color by makeup so that the attached part cannot be distinguished from other parts of the skin can be reduced. .
[皮肤遮蔽材料的透湿度][moisture permeability of the skin covering material]
皮肤遮蔽材料(2a、2b)的透湿度可以为400g/(m2·天)以上。日常从皮肤表面散发300g/(m2·天)左右的水蒸气，因此，将透湿度低的薄膜贴附于皮肤时，皮肤闷热而皮肤常驻菌增殖，有可能引发炎症。与此相对，皮肤遮蔽材料(2a、2b)的透湿度为400g/(m2·天)以上时，皮肤表面散发的水蒸气会透过皮肤遮蔽材料(2a、2b)。此时，将皮肤遮蔽材料(2a、2b)贴附于皮肤时，能够避免皮肤的闷热、因闷热而引发的皮肤损害。The moisture permeability of the skin masking materials (2a, 2b) may be 400 g/(m2 ·day) or more. About 300g/(m2 ·day) of water vapor is emitted from the surface of the skin on a daily basis. Therefore, when a film with low moisture permeability is attached to the skin, the skin will be stuffy and resident bacteria will proliferate, which may cause inflammation. On the other hand, when the moisture permeability of the skin masking materials (2a, 2b) is 400 g/(m2 ·day) or more, water vapor emitted from the skin surface will pass through the skin masking materials (2a, 2b). In this case, when the skin masking materials (2a, 2b) are attached to the skin, stuffiness of the skin and skin damage caused by the stuffiness can be avoided.
皮肤遮蔽材料(2a、2b)的透湿度进一步优选为900～5,000g/(m2·天)。透湿度为900g/(m2·天)以上时，贴附有皮肤遮蔽材料(2a、2b)时，可以基本消除皮肤的闷热感。透湿度为5,000g/(m2·天)以下时，水、汗或醇被皮肤遮蔽材料(2a、2b)吸收，这时，能够避免皮肤遮蔽材料(2a、2b)溶胀伸缩、容易剥脱而变得显眼。进而，透湿度为900～5,000g/(m2·天)时，将皮肤遮蔽材料(2a、2b)贴附于创处时，创面维持湿润状态，能够通过湿润疗法来进行创处的快速治疗。皮肤遮蔽材料(2a、2b)的透湿度更进一步优选为1,000～3,000g/(m2·天)。The moisture permeability of the skin masking materials (2a, 2b) is more preferably 900 to 5,000 g/(m2 ·day). When the moisture permeability is 900 g/(m2 ·day) or more, when the skin masking materials (2a, 2b) are attached, the stuffy feeling of the skin can be basically eliminated. When the moisture permeability is below 5,000g/(m2 ·day), water, sweat or alcohol are absorbed by the skin masking material (2a, 2b). become conspicuous. Furthermore, when the moisture permeability is 900 to 5,000 g/(m2 ·day), when the skin masking material (2a, 2b) is attached to the wound, the wound remains moist, and the wound can be quickly treated by moist therapy . The moisture permeability of the skin masking materials (2a, 2b) is still more preferably 1,000 to 3,000 g/(m2 ·day).
皮肤遮蔽材料(2a、2b)的透湿度受薄膜层4a的材质、形状和厚度的影响。作为薄膜层4a的原材料，优选使用制成30μm厚度时透湿度为1,000g/(m2·天)以上的薄膜。薄膜层4a使用透湿度高的原材料时，即使增大薄膜层4a的厚度w，也能够在粘贴皮肤遮蔽材料(2a、2b)时基本消除皮肤的闷热感。The moisture permeability of the skin masking materials (2a, 2b) is affected by the material, shape and thickness of the film layer 4a. As the raw material of the film layer 4a, a film having a water vapor transmission rate of 1,000 g/(m2 ·day) or more at a thickness of 30 μm is preferably used. When the film layer 4a uses a material with high moisture permeability, even if the thickness w of the film layer 4a is increased, the stuffy feeling of the skin can be basically eliminated when sticking the skin masking materials (2a, 2b).
皮肤遮蔽材料(2a、2b)的透湿度还受到另一面(10a、10b)的Rz大小的影响。皮肤遮蔽材料(2a、2b)将另一面(10a、10b)形成有大量较深的微细孔的薄膜用作原材料时，薄膜层4a显示高的透湿度。另外，皮肤遮蔽材料(2a、2b)的形成于另一面(10a、10b)的凹凸的高低差的尺寸相对于薄膜层4a的厚度w所占的比率有时非常大。此时，即使使用透湿度低的薄膜或者较厚的薄膜作为薄膜层4a的原材料，薄膜层4a也能够显示出高透湿度。The moisture permeability of the skin masking material (2a, 2b) is also affected by the magnitude of Rz on the other side (10a, 10b). When the skin masking material (2a, 2b) uses a film having a large number of deep micropores formed on the other side (10a, 10b) as a raw material, the film layer 4a exhibits high moisture permeability. In addition, the ratio of the size of the unevenness formed on the other surface (10a, 10b) of the skin masking material (2a, 2b) to the thickness w of the film layer 4a may be very large. In this case, even if a film with low moisture permeability or a thick film is used as the raw material of the film layer 4a, the film layer 4a can exhibit high moisture permeability.
皮肤遮蔽材料(2a、2b)在从形成于另一面(10a、10b)的凹凸中的凹部孔底至薄膜层4a的一面12为止的距离为30μm以下时能够显示出特别高的透湿度。即，薄膜层4a的厚度w为0μm＜w≤30μm时，无论Rz值如何均显示出特别高的透湿度。另外，30μm＜w时，若进而(w-30μm)＜Rz≤w，则能够显示出特别高的透湿度。The skin masking material (2a, 2b) exhibits a particularly high water vapor transmission rate when the distance from the bottom of the hole formed in the concavities and convexities of the other surface (10a, 10b) to the surface 12 of the film layer 4a is 30 μm or less. That is, when the thickness w of the thin film layer 4a is 0 μm<w≦30 μm, a particularly high water vapor transmission rate is exhibited regardless of the Rz value. In addition, when 30 μm<w, and further (w−30 μm)<Rz≦w, a particularly high water vapor transmission rate can be exhibited.
薄膜层4a的透湿度基于JIS Z 0208按照杯法来测定。测定中，吸湿剂使用氯化钙，密封剂使用作为试剂的市售的熔点为52～54℃的石蜡。测定中，将放有吸湿剂的杯子设置在温度40℃、湿度90％RH的恒温恒湿槽内，自测定开始起每隔1.5小时测定一次杯整体的增重，共测定三次。透湿度的值根据第2次和第3次测定的平均值求出。The water vapor transmission rate of the film layer 4a was measured by the cup method based on JIS Z 0208. In the measurement, calcium chloride was used as a hygroscopic agent, and commercially available paraffin wax having a melting point of 52 to 54° C. as a reagent was used as a sealing agent. During the measurement, the cup with the hygroscopic agent was placed in a constant temperature and humidity tank with a temperature of 40°C and a humidity of 90% RH, and the weight gain of the entire cup was measured every 1.5 hours from the start of the measurement, and the measurement was performed three times in total. The value of water vapor transmission rate was calculated|required from the average value of the 2nd and 3rd measurement.
[在常温下为液体且具有极性基团的有机化合物等][Organic compounds that are liquid at normal temperature and have polar groups, etc.]
粘合剂层6a可以包含10～50重量％的在常温下为液体且具有极性基团的有机化合物。此处的常温是指5～35℃。在常温下为液体且具有极性基团的有机化合物相对于粘合剂层6a低于10重量％时，根据成为原材料的粘合剂的组成的不同，粘合剂层6a不会形成凝胶状。另外，相对于粘合剂层6a超过50重量％时，根据粘合剂的组成的不同，有可能不会在粘合剂层6a形成凝胶体，粘合剂层6a的粘接力变得不充分。The adhesive layer 6a may contain 10 to 50% by weight of an organic compound that is liquid at normal temperature and has a polar group. The normal temperature here means 5-35 degreeC. When the organic compound that is liquid at normal temperature and has a polar group is less than 10% by weight relative to the adhesive layer 6a, the adhesive layer 6a will not form a gel depending on the composition of the adhesive used as the raw material. shape. In addition, when it exceeds 50% by weight with respect to the adhesive layer 6a, depending on the composition of the adhesive, a gel may not be formed in the adhesive layer 6a, and the adhesive force of the adhesive layer 6a may decrease. insufficient.
此处，极性基团是指酰胺基、氨基、醛基、醚基、酯基、羧基、酮基、磺基、羟基、磷酸基等具有极性的官能团。作为在常温下为液体且具有极性基团的有机化合物，可列举出选自由脂肪酸酯、山梨糖醇酐脂肪酸酯、聚氧乙烯山梨糖醇酐脂肪酸酯、聚氧乙烯山梨醇脂肪酸酯、聚氧乙烯烷基醚、聚氧乙烯氢化蓖麻油、甘油脂肪酸酯、聚甘油脂肪酸酯、聚氧乙烯甘油脂肪酸酯、脂肪酸、脂肪族醇、磷脂、1,3-丁二醇、甘油、聚乙二醇等多元醇、以及它们的混合物组成的组中的有机化合物。Here, the polar group refers to a polar functional group such as an amide group, an amino group, an aldehyde group, an ether group, an ester group, a carboxyl group, a ketone group, a sulfo group, a hydroxyl group, or a phosphoric acid group. Examples of organic compounds that are liquid at room temperature and have a polar group include fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters. Esters, polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, glycerin fatty acid esters, polyglycerol fatty acid esters, polyoxyethylene glycerin fatty acid esters, fatty acids, fatty alcohols, phospholipids, 1,3-butanediene Organic compounds in the group consisting of polyhydric alcohols such as alcohols, glycerin, polyethylene glycol, and mixtures thereof.
粘合剂层6a包含10～50重量％的在常温下为液体且具有极性基团的有机化合物时，粘合剂层6a成为凝胶状，因此，皮肤遮蔽材料(2a、2b)会缓和因皮肤的伸缩而产生的应力。另外，由于有机化合物为亲水性的物质或者极性高的物质，因此，皮肤遮蔽材料(2a、2b)的粘合剂层6a显示高的透湿度。因此，皮肤遮蔽材料(2a、2b)能抑制贴附有皮肤遮蔽材料(2a、2b)的部位的皮肤处产生斑疹，并且使用者不易产生不适感。另外，能减少将皮肤遮蔽材料(2a、2b)从皮肤剥离时对皮肤的刺激，从而抑制角质的损伤。粘合剂层6a为凝胶状、皮肤遮蔽材料(2a、2b)的透湿度为900～5,000g/(m2·天)时，将所述皮肤遮蔽材料(2a、2b)贴附于伤口等异质部分时，异质部分被维持为湿润状态，可确认到异质部分的快速治愈。When the adhesive layer 6a contains 10 to 50% by weight of an organic compound that is liquid at room temperature and has a polar group, the adhesive layer 6a becomes gel-like, so that the skin masking materials (2a, 2b) are relaxed. Stress due to expansion and contraction of the skin. In addition, since the organic compound is a hydrophilic substance or a highly polar substance, the adhesive layer 6a of the skin masking materials (2a, 2b) exhibits high moisture permeability. Therefore, the skin-masking material (2a, 2b) can suppress skin rashes at the site where the skin-masking material (2a, 2b) is attached, and the user is less likely to feel uncomfortable. In addition, it is possible to reduce irritation to the skin when the skin masking material (2a, 2b) is peeled off from the skin, thereby suppressing damage to the keratin. When the adhesive layer 6a is gel-like and the moisture permeability of the skin masking materials (2a, 2b) is 900 to 5,000 g/(m2 ·day), stick the skin masking materials (2a, 2b) on the wound When waiting for the heterogeneous part, the heterogeneous part is maintained in a moist state, and rapid healing of the heterogeneous part can be confirmed.
粘合剂层6a中包含的有机化合物可以是选自由角鲨烷、角鲨烯、聚丁烯、聚异丁烯等烃系化合物和它们的混合物组成的组中的烃系化合物。粘合剂层6a中包含的有机化合物可以为1种以上的表面活性剂。The organic compound contained in the adhesive layer 6 a may be a hydrocarbon-based compound selected from the group consisting of squalane, squalene, polybutene, polyisobutylene, and other hydrocarbon-based compounds, and mixtures thereof. The organic compound contained in the adhesive layer 6a may be one or more surfactants.
一直以来，为了治疗痤疮、伤口、伤痕等皮肤的异质部分，市售有用于治疗痤疮的软膏、霜等。但是，应避免在异质部分涂覆软膏等，并进一步在其上覆盖化妆品。同样地，对痤疮、小脓疱粘贴贴附材也是不好的。认为其原因是分泌腺会因软膏等、贴附材料而被堵塞，细菌有可能在异质部分发生增殖。Conventionally, ointments, creams, and the like for treating acne have been commercially available to treat heterogeneous parts of the skin such as acne, wounds, and scars. However, it should be avoided to apply ointment etc. on the heterogeneous part and further cover it with cosmetics. Similarly, it is also not good to stick to acne and small pustules. The reason for this is considered to be that the secretory glands are clogged with ointment, etc., and adhesive materials, and bacteria may proliferate in heterogeneous parts.
因此，以往皮肤产生异质部分时，难以同时兼顾用于模糊其与皮肤的其它部分的差异的覆盖和皮肤异质部分的治疗。或者优先覆盖、或者优先治疗，需要选择其中的一者。在意自身外观的人会感到很不便。Therefore, in the past, when skin has heterogeneous parts, it has been difficult to simultaneously cover the skin for blurring the difference from other parts of the skin and treat the skin heterogeneous parts. Or priority coverage, or priority treatment, you need to choose one of them. People who are concerned about their appearance will find it very inconvenient.
[针对皮肤的药效成分][Effective ingredients for the skin]
相对于此，粘合剂层6a可以包含针对皮肤的药效成分。通过该构成，将皮肤遮蔽材料(2a、2b)贴附于皮肤的异质部分时，能够使该部分恢复而得以治疗。例如，药效成分具有溶解会堵塞分泌腺、汗腺的皮脂等的功能、抗菌作用时，若将皮肤遮蔽材料(2a、2b)粘贴于痤疮、小脓疱之类的皮肤患病部分，则能够在遮蔽的同时对患病部分进行治疗。需要说明的是，即使药效成分在常温下为固体时，若粘合剂层6a包含脂肪酸酯等，则药效成分能够溶解于脂肪酸酯等而发挥出前述的治疗效果。On the other hand, the adhesive layer 6a may contain a medicinal ingredient for skin. With this configuration, when the skin masking material (2a, 2b) is attached to a heterogeneous part of the skin, the part can be restored and treated. For example, when the medicinal ingredients have the function of dissolving sebum that can block the secretory glands and sweat glands, etc., and have an antibacterial effect, if the skin masking materials (2a, 2b) are pasted on the affected parts of the skin such as acne and small pustules, it can Treat the diseased part while masking. It should be noted that even when the medicinal ingredients are solid at normal temperature, if the adhesive layer 6a contains fatty acid esters, etc., the medicinal ingredients can be dissolved in the fatty acid esters to exert the aforementioned therapeutic effect.
因而，粘合剂层6a包含针对皮肤的药效成分的情况下，将皮肤遮蔽材料(2a、2b)粘贴于痤疮、小脓疱、伤口等皮肤异质部分并化妆时，不仅能够使其与皮肤的其它部分的差异变得难以分辨，同时能够有助于治疗异质部分。Therefore, when the adhesive layer 6a contains medicinal ingredients for the skin, when the skin masking materials (2a, 2b) are pasted on heterogeneous parts of the skin such as acne, small pustules, and wounds for makeup, not only can it be combined with Differences in other parts of the skin become difficult to discern and can help treat heterogeneous parts.
为了使粘合剂层6a包含药效成分，在前述皮肤遮蔽材料(2a、2b)的制造方法中，将药效成分添加至流延前的流延溶液并混合，将混合后的流延用溶液流延在剥离片材上。其它采取与前述皮肤遮蔽材料(2a、2b)的制造方法相同的方法时，能够得到在粘合剂层6a中包含药效成分的皮肤遮蔽材料(2a、2b)。In order to make the adhesive layer 6a contain medicinal ingredients, in the above-mentioned manufacturing method of the skin masking materials (2a, 2b), the medicinal ingredients are added to the casting solution before casting and mixed, and the mixed casting solution is mixed. The solution was cast on a release sheet. Others When the same method as the production method of the above-mentioned skin masking materials (2a, 2b) is adopted, the skin masking materials (2a, 2b) containing the medicinal ingredients in the adhesive layer 6a can be obtained.
[α-羟基酸类、水杨酸][alpha hydroxy acids, salicylic acid]
作为药效成分，可列举出选自由α-羟基酸类、水杨酸和它们的混合物组成的组中的化合物。作为α-羟基酸类，可例示出乳酸、枸橼酸、羟基乙酸、苹果酸、琥珀酸等。这些成分具有软化角质、扩张毛孔等作用，因此，若包含于粘合剂层6a，则能够将皮肤遮蔽材料(2a、2b)用于治疗皮肤疾病。另外，由于这些成分为酸性，因此用于治疗皮肤的创伤时，能够抑制皮肤常驻菌的增殖，使创伤得以良好的治疗。α-羟基酸类、水杨酸优选以相对于粘合剂层6a达到0.1～10重量％的方式进行添加。Examples of medicinal ingredients include compounds selected from the group consisting of α-hydroxy acids, salicylic acid, and mixtures thereof. Examples of the α-hydroxy acids include lactic acid, citric acid, glycolic acid, malic acid, succinic acid and the like. These components have functions such as softening cuticles and expanding pores. Therefore, if contained in the adhesive layer 6a, the skin masking materials (2a, 2b) can be used to treat skin diseases. In addition, since these components are acidic, when used to treat skin wounds, the proliferation of skin-resident bacteria can be suppressed, and wounds can be treated well. α-Hydroxy acids and salicylic acid are preferably added in an amount of 0.1 to 10% by weight based on the pressure-sensitive adhesive layer 6a.
[抗菌剂][Antibacterial agents]
作为药效成分，可列举出抗菌剂。抗菌剂优选以相对于粘合剂层6a达到0.01～20重量％的方式进行添加。通过该构成，在贴附有皮肤遮蔽材料(2a、2b)的部位发挥出抗菌作用、杀菌作用，能够抑制细菌的增殖。抗菌剂进一步优选以相对于粘合剂层6a达到0.05～5重量％的方式进行添加。An antibacterial agent is mentioned as a medically effective ingredient. It is preferable to add an antimicrobial agent so that it may become 0.01-20 weight% with respect to the adhesive layer 6a. With this configuration, antibacterial and bactericidal effects can be exerted on the parts where the skin masking materials (2a, 2b) are attached, and the growth of bacteria can be suppressed. It is more preferable to add the antimicrobial agent so that it may become 0.05-5 weight% with respect to the adhesive layer 6a.
作为抗菌剂，可列举出选自由异丙基甲基苯酚、银系抗菌剂和它们的混合物组成的组中的化合物。异丙基甲基苯酚是3-甲基-4-异丙基苯酚。另外，作为银系抗菌剂，可列举出选自由银胶体、银沸石等内含银的物质、银系化合物和它们的混合物组成的组中的化合物。这些抗菌剂显示高的抗菌性和安全性，基本没有皮肤刺激性，可用作医药外用品、化妆品的添加物。使这些抗菌剂包含于粘合剂层6a时，皮肤遮蔽材料(2a、2b)能够方便地用于日常生活的各种情况。Examples of the antibacterial agent include compounds selected from the group consisting of isopropylmethylphenol, silver-based antibacterial agents, and mixtures thereof. Isopropylmethylphenol is 3-methyl-4-isopropylphenol. In addition, examples of the silver-based antibacterial agent include compounds selected from the group consisting of silver-containing substances such as silver colloid and silver zeolite, silver-based compounds, and mixtures thereof. These antibacterial agents exhibit high antibacterial properties and safety, are basically non-irritating to the skin, and can be used as additives for quasi-drugs and cosmetics. When these antibacterial agents are contained in the adhesive layer 6a, the skin masking materials (2a, 2b) can be conveniently used in various situations of daily life.
另外，作为抗菌剂，可列举出选自由卡那霉素硫酸盐、庆大霉素硫酸盐、弗氏霉素硫酸盐、红霉素、四环素盐酸盐、氧四环素盐酸盐、去甲基氯四环素盐酸盐、氯霉素、杆菌肽、夫西地酸钠、磺胺嘧啶银等抗菌药和它们的混合物组成的组中的化合物。这些抗菌药一直以来以软膏、贴附剂等的方式用于医药品。使这些抗菌药包含于粘合剂层6a时，能够将皮肤遮蔽材料(2a、2b)用作皮肤的相关医药品。In addition, as an antibacterial agent, there may be mentioned selected from kanamycin sulfate, gentamicin sulfate, freundmycin sulfate, erythromycin, tetracycline hydrochloride, oxytetracycline hydrochloride, desmethyl Compounds in the group consisting of antibacterial drugs such as chlortetracycline hydrochloride, chloramphenicol, bacitracin, sodium fusidate, silver sulfadiazine, and mixtures thereof. These antibacterial agents have been used in pharmaceuticals in the form of ointments, patches, and the like. When these antibacterial drugs are contained in the adhesive layer 6a, the skin masking materials (2a, 2b) can be used as skin-related medicines.
[抗炎药][anti-inflammatory drug]
作为药效成分，可列举出抗炎药。作为抗炎药，可列举出选自由消炎痛、吡罗昔康、联苯乙酸、洛索洛芬钠、双氯芬酸钠、酮洛芬、氟比洛芬、皮考布洛芬、布洛芬、氟灭酸、舒洛芬、丁苯羟酸、苄达酸、乌芬那酯、甘草酸或其衍生物等非类固醇消炎镇痛剂、以及它们的混合物组成的组中的化合物。特别适宜为抗炎药皮考布洛芬与抗菌剂异丙基甲基苯酚的组合。Anti-inflammatory drugs are exemplified as the medicinal ingredients. Examples of the anti-inflammatory drug include indomethacin, piroxicam, felbinac, loxoprofen sodium, diclofenac sodium, ketoprofen, flurbiprofen, pico ibuprofen, ibuprofen, and flurfenac. Compounds in the group consisting of non-steroidal anti-inflammatory analgesics such as suprofen, butylfenoxylic acid, benzacic acid, upenamate, glycyrrhizic acid or its derivatives, and mixtures thereof. Particularly suitable is the combination of the anti-inflammatory drug pico ibuprofen and the antibacterial agent isopropylmethylphenol.
[其它针对皮肤的药效成分等][Other medicinal ingredients for the skin, etc.]
除此之外，作为药效成分，可列举出选自由色甘酸钠、曲尼司特、富马酸酮替芬、氮卓斯汀盐酸盐、奥沙米特、美喹他嗪、非索非那定盐酸盐、依匹斯汀盐酸盐、依巴斯汀、西替利嗪盐酸盐、苯磺贝他斯汀、奥洛他定盐酸盐、氯雷他定、甲磺司特等抗过敏药、以及它们的混合物组成的组中的化合物。作为药效成分，可列举出选自由甘菊蓝、磺胺嘧啶、铝克洛沙、溶菌酶盐酸盐、托可维A酸、布拉地新钠、前列地尔阿法环糊精(Alprostadil alfadex)、曲弗明(基因重组)等皮肤溃疡治疗药、以及它们的混合物组成的组中的化合物。这些医药品一直以来被用作皮肤科用剂。In addition, as the active ingredients, there may be mentioned cromolyn sodium, tranilast, ketotifen fumarate, azelastine hydrochloride, oxamide, mequitazine, Solifenadine hydrochloride, epinastine hydrochloride, ebastine, cetirizine hydrochloride, bepotastine besilate, olopatadine hydrochloride, loratadine, formazan Compounds in the group consisting of antiallergic drugs such as sulfalast, and mixtures thereof. As the active ingredients, there can be listed selected from azulene, sulfadiazine, alcloxa, lysozyme hydrochloride, tocotretinoin, bradixin sodium, alprostadil alpha cyclodextrin (Alprostadil alfadex), triformin (recombinant gene) and other skin ulcer therapeutic agents, and compounds in the group consisting of mixtures thereof. These pharmaceuticals have been used conventionally as dermatological agents.
另外，作为药效成分，可列举出选自由克罗米通等止痒药、他克莫司水合物等特异性皮炎治疗药、甲氧沙林等白斑治疗药、孕二醇、那氟沙星、克林霉素磷酸酯、阿达帕林等痤疮治疗药、阿维A酯、他卡西醇水合物、卡泊三醇、玛莎骨化醇、维生素A、尿素、环孢菌素等角化症·干癣治疗药、水杨酸等皮肤软化药、卡普氯铵、非那雄胺等脱毛治疗药、氨苯砜、氯法齐明、利福平、氧氟沙星等麻风病治疗药、肝素钠、肝素类似物质等促进血液循环·皮肤保湿剂、白色凡士林、咪喹莫特等皮肤科用剂、以及它们的混合物组成的组中的化合物。这些医药品一直以来被用作皮肤科用剂。In addition, examples of the active ingredients include antipruritics such as crotamiton, atopic dermatitis therapeutics such as tacrolimus hydrate, leukoplakia therapeutics such as methoxsalen, pregestediol, nafloxa Star, clindamycin phosphate, adapalene and other acne treatment drugs, acitretin, tacalcitol hydrate, calcipotriol, masacalcidol, vitamin A, urea, cyclosporin, etc. Drugs for keratosis and psoriasis, skin softening drugs such as salicylic acid, hair removal drugs such as carpronium chloride and finasteride, leprosy such as dapsone, clofazimine, rifampicin, ofloxacin, etc. Compounds in the group consisting of anti-disease drugs, heparin sodium, heparin analogues and other blood circulation promoting and skin moisturizing agents, white petrolatum, imiquimod and other dermatological agents, and mixtures thereof. These pharmaceuticals have been used conventionally as dermatological agents.
作为药效成分，可列举出选自由维生素C、其衍生物、维生素E、其衍生物、芍药提取物、当归提取物、紫草根提取物、硫磺、去甲二氢愈创木酸、以及它们的混合物组成的组中的化合物。药效成分可列举出选自由具有保湿效果的透明质酸等硫酸多糖类、甘油、丁二醇、聚乙二醇等多元醇等、以及它们的混合物组成的组中的化合物。药效成分可以包含1种以上的具有药效的植物提取物。Examples of medicinal ingredients include vitamin C, its derivatives, vitamin E, its derivatives, peony extract, angelica extract, comfrey root extract, sulfur, nordihydroguaiaretic acid, and their Compounds in the group consisting of mixtures. Examples of medicinal ingredients include compounds selected from the group consisting of sulfated polysaccharides such as hyaluronic acid having a moisturizing effect, polyalcohols such as glycerin, butylene glycol, and polyethylene glycol, and mixtures thereof. The medicinal ingredient may contain one or more medicinal herbal extracts.
药效成分可以为养发用药剂、血液循环促进剂、刺激剂、激素类、抗皱剂、抗老化剂、紧致剂、冷感剂、温感剂、创伤治疗促进剂、刺激缓和剂、细胞赋活剂、植物·动物·微生物提取物、止痒剂、角质剥离·溶解剂、止汗剂、清凉剂、收敛剂等。药效成分可以包含1种以上的例如百里酚之类的医药品原料药。The medicinal ingredients can be hair nourishing agents, blood circulation promoters, stimulators, hormones, anti-wrinkle agents, anti-aging agents, firming agents, cooling agents, warming agents, wound treatment accelerators, stimulation alleviating agents, cell Active agents, plant, animal, and microbial extracts, antipruritic agents, exfoliating and dissolving agents, antiperspirants, cooling agents, astringents, etc. The medicinal ingredient may contain one or more types of pharmaceutical raw materials such as thymol.
粘合剂层6a可以包含消毒药。作为消毒药，可列举出选自由乙醇、异丙醇、聚维酮碘等碘系物质、苄索氯铵、苯扎氯铵、葡萄糖酸氯己定、烷基二氨基乙基甘氨酸等、以及它们的混合物组成的组中的化合物。这些消毒药一直以来用于手指、皮肤的消毒。The adhesive layer 6a may contain a disinfectant. Examples of the disinfectant include iodine-based substances such as ethanol, isopropanol, povidone iodine, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, alkyldiaminoethylglycine, etc., and Compounds in the group consisting of their mixtures. These disinfectants have been used for disinfection of fingers and skin.
粘合剂层6a可以包含选自由二丁基羟基甲苯、丁基羟基茴香醚等抗氧化剂和它们的混合物组成的组中的化合物。The adhesive layer 6a may contain a compound selected from the group consisting of antioxidants such as dibutylhydroxytoluene, butylated hydroxyanisole, and mixtures thereof.
[聚醚聚氨酯或聚酯聚氨酯][Polyether urethane or polyester urethane]
薄膜层4a的原材料优选为聚醚聚氨酯(EU)或聚酯聚氨酯的薄膜。通过该构成，薄膜层4a具备高伸缩性和高透湿性。此时，皮肤遮蔽材料(2a、2b)在贴附时与皮肤吻合。另外，进一步在其上涂布粉底和遮瑕膏之类的化妆品时，形成于另一面(10a、10b)的凹部内保持的粉末因皮肤表面散发的水蒸气而湿润，其粘性提高。因此，凹部内更容易保持粉末。需要说明的是，聚醚聚氨酯(EU)或聚酯聚氨酯的薄膜的表面平滑且其厚度为30μm时，透湿度达到950g/(m2·天)以上。另外，聚醚聚氨酯(EU)、聚酯聚氨酯是具有极性基团的原材料，因此，能够用水溶性染料使另一面(10a、10b)着色。The raw material of the film layer 4a is preferably a film of polyether polyurethane (EU) or polyester polyurethane. With this configuration, the film layer 4a has high stretchability and high moisture permeability. At this time, the skin masking materials (2a, 2b) conform to the skin when attached. In addition, when cosmetics such as foundation and concealer are further applied thereon, the powder held in the concave portion formed on the other surface (10a, 10b) is wetted by the water vapor emitted from the skin surface, and its viscosity increases. Therefore, it is easier to hold the powder in the recess. In addition, when the surface of the polyether polyurethane (EU) or polyester polyurethane film is smooth and its thickness is 30 μm, the water vapor transmission rate is 950 g/(m2 ·day) or more. In addition, since polyether urethane (EU) and polyester urethane are materials having polar groups, the other surface (10a, 10b) can be colored with a water-soluble dye.
[薄膜层的厚度][thickness of film layer]
薄膜层4a的厚度w可以为6μm≤w≤100μm。W低于6μm时，薄膜层4a的强度不足。w超过100μm时，薄膜层4a的拉伸弹性模量变得过大，皮肤遮蔽材料(2a、2b)不与皮肤的曲面吻合。另外，皮肤遮蔽材料(2a、2b)不会追随于皮肤的伸缩，因此，使用者有可能产生不适感。The thickness w of the thin film layer 4a may be 6 μm≦w≦100 μm. When W is less than 6 μm, the strength of the thin film layer 4 a is insufficient. When w exceeds 100 μm, the tensile elastic modulus of the film layer 4a becomes too large, and the skin masking materials (2a, 2b) do not conform to the curved surface of the skin. In addition, since the skin masking materials (2a, 2b) do not follow the expansion and contraction of the skin, the user may feel uncomfortable.
薄膜层4a的厚度w进一步优选为10μm≤w≤60μm。由于另一面(10a、10b)形成有凹部，因此，w为6μm≤w＜10μm时，薄膜层4a的强度有时不充分。另外，w为60μm＜w≤100μm时，根据成为薄膜层4a原材料的薄膜的不同，皮肤遮蔽材料(2a、2b)的透湿度不会达到900g/(m2·天)以上，因此，使用者有可能感到皮肤闷热。The thickness w of the film layer 4 a is more preferably 10 μm≦w≦60 μm. Since the concave portion is formed on the other surface (10a, 10b), when w is 6 μm≦w<10 μm, the strength of the thin film layer 4 a may not be sufficient. In addition, when w is 60 μm<w≤100 μm, depending on the film used as the raw material of the film layer 4a, the moisture permeability of the skin masking materials (2a, 2b) will not reach more than 900g/(m2 ·day). Skin may feel hot.
[其它实施方式][Other Embodiments]
关于图2～5所示的其它实施方式的皮肤遮蔽材料(2f、2g、2h、2i、2j)，对其与皮肤遮蔽材料(2a、2b)不同的构成和作用效果进行说明。Regarding skin masking materials ( 2f , 2g , 2h , 2i , 2j ) of other embodiments shown in FIGS. 2 to 5 , their configurations and effects different from those of the skin masking materials ( 2a , 2b ) will be described.
图2所示的皮肤遮蔽材料2f中的薄膜层4f的原材料是层叠有具有凹凸的氨酯薄膜34和疏水性薄膜36的复合薄膜38。作为疏水性薄膜36的材质，可列举出选自由聚烯烃树脂、热塑性弹性体、橡胶系树脂和它们的混合物组成的组中的疏水性合成树脂。此处，作为热塑性弹性体，可列举出苯乙烯异戊二烯苯乙烯嵌段共聚物、苯乙烯丁二烯共聚物和它们的基于丙烯酸类等的改性物。另外，此处作为橡胶系树脂，可列举出异戊二烯橡胶、丁基橡胶、聚异丁烯和它们的改性物。复合薄膜38如下获得：向表面具有凹凸的反转图案的基板的表面流延氨酯树脂溶液，干燥而形成薄膜，进一步使用成为疏水性薄膜36原料的树脂溶液在氨酯树脂的薄膜上形成薄膜，将所得层叠物从基板上剥离。The material of the film layer 4f in the skin masking material 2f shown in FIG. 2 is a composite film 38 in which a urethane film 34 having irregularities and a hydrophobic film 36 are laminated. Examples of the material of the hydrophobic film 36 include hydrophobic synthetic resins selected from the group consisting of polyolefin resins, thermoplastic elastomers, rubber-based resins, and mixtures thereof. Here, examples of thermoplastic elastomers include styrene-isoprene-styrene block copolymers, styrene-butadiene copolymers, and their modified products based on acrylics and the like. In addition, examples of the rubber-based resin here include isoprene rubber, butyl rubber, polyisobutylene, and modified products thereof. The composite film 38 is obtained by casting a urethane resin solution on the surface of a substrate having a concave-convex reverse pattern on the surface, drying it to form a film, and further forming a film on the urethane resin film using the resin solution used as a raw material for the hydrophobic film 36. , and the resulting laminate was peeled off from the substrate.
薄膜层4f的另一面10f侧是具有使基板表面的反转图案转印而形成的凹凸的氨酯薄膜34，其一面12侧为疏水性薄膜36。另外，优选的是，薄膜层4f的疏水性薄膜36的厚度v为2μm≤v≤10μm、且v＜(w/2)，形成有另一面10f的Rz达到Rz≤(w-1μm)的凹凸。The other surface 10f side of the film layer 4f is a urethane film 34 having concavities and convexities formed by transferring a reverse pattern on the substrate surface, and the one surface 12 side is a hydrophobic film 36 . In addition, it is preferable that the thickness v of the hydrophobic thin film 36 of the thin film layer 4f is 2 μm≤v≤10 μm, and v<(w/2), and the Rz of the other surface 10 f is formed with irregularities such that Rz≤(w-1 μm). .
通过该构成，疏水性薄膜36薄至2μm≤w≤10μm，因此，薄膜层4f的透湿度的降低被抑制在最小限度。另外，由于2μm≤v≤10μm、且Rz≤(w-1μm)，因此，即使形成于另一面10f的凹部成为贯穿氨酯薄膜34的贯穿孔，也不会成为贯穿至疏水性薄膜36为止的贯穿孔。从凹部的孔底至薄膜层4的一面12为止之间具有厚度至少为1μm以上的疏水性薄膜36的层。进而，疏水性薄膜36阻止药效成分的透过，因此，粘合剂层6a中包含的药效成分不会移动至氨酯薄膜34。因此，使用复合薄膜38作为薄膜层4f原材料的皮肤遮蔽材料2f在维持400g/(m2·天)以上的透湿度的同时，高效地向皮肤释放药效成分。With this configuration, the water-repellent thin film 36 is as thin as 2 μm≦w≦10 μm, so that the decrease in the water vapor transmission rate of the thin film layer 4 f is suppressed to a minimum. In addition, since 2 μm≦v≦10 μm and Rz≦(w−1 μm), even if the concave portion formed on the other surface 10 f becomes a through hole penetrating the urethane film 34 , it does not become a hole penetrating to the hydrophobic film 36 . through hole. A layer of a hydrophobic thin film 36 having a thickness of at least 1 μm is present from the bottom of the recessed portion to one surface 12 of the thin film layer 4 . Furthermore, since the hydrophobic film 36 prevents the permeation of the medicinal ingredient, the medicinal ingredient contained in the adhesive layer 6 a does not migrate to the urethane film 34 . Therefore, the skin masking material 2f using the composite film 38 as the material of the film layer 4f efficiently releases the medicinal ingredient to the skin while maintaining a moisture permeability of 400 g/(m2 ·day) or more.
图3所示的皮肤遮蔽材料2g是其薄膜层4g层叠有具有凹凸的薄膜40和红色薄膜42的复合薄膜44。具有凹凸的薄膜40的颜色为选自由无色透明、乳白色且半透明、以及处于这些颜色之间的颜色组成的组中的颜色。复合薄膜44如下获得：将成为具有凹凸的薄膜40的原料的树脂溶液流延在表面具有凹凸的反转图案的基板的表面并干燥，进一步在干燥树脂上流延成为红色薄膜42原料的树脂溶液，进行干燥，将所得层叠物从基板上剥离，由此获得。A skin masking material 2g shown in FIG. 3 is a composite film 44 in which a film layer 4g having irregularities and a red film 42 are laminated. The color of the uneven film 40 is a color selected from the group consisting of colorless and transparent, milky white and translucent, and colors in between. The composite film 44 is obtained by casting a resin solution as a raw material of the film 40 having concavities and convexities on the surface of a substrate having a concavo-convex reverse pattern on the surface and drying it, and further casting the resin solution as a raw material of the red film 42 on the dried resin, Drying is performed, and the obtained laminate is peeled off from the substrate, thereby obtaining.
制造复合薄膜44时，向成为具有凹凸的薄膜40的原料的树脂溶液中添加作为微粒的颜料、氧化钛、滑石、二氧化硅等，进一步添加硅油。通过添加微粒，具有凹凸的薄膜40呈现无色透明、乳白色且半透明、或者处于这些颜色之间的颜色。通过添加硅油，容易从基板上剥离复合薄膜44。另外，成为红色薄膜42原料的树脂溶液可以使用弹性模量低的树脂，进一步添加微粒。通过使用弹性模量低的树脂，红色薄膜42的质地变软。成为红色薄膜42原料的树脂溶液为淡红色，因此，通过添加微粒，红色薄膜42变为淡红色。When manufacturing the composite thin film 44 , pigments, titanium oxide, talc, silica, etc. as fine particles are added to the resin solution used as the raw material of the uneven thin film 40 , and silicone oil is further added. By adding fine particles, the thin film 40 having concavities and convexities becomes colorless and transparent, milky white and translucent, or a color between these colors. By adding silicone oil, the composite thin film 44 is easily peeled off from the substrate. In addition, the resin solution used as the raw material of the red thin film 42 may use a resin with a low elastic modulus, and further add fine particles. By using a resin with a low elastic modulus, the texture of the red film 42 becomes soft. Since the resin solution used as the raw material of the red thin film 42 is light red, adding fine particles changes the red thin film 42 to light red.
薄膜层4g的另一面10g侧是具有经转印基板表面的反转图案而形成的凹凸的薄膜40，其一面12侧为红色薄膜42。On the other side 10g of the film layer 4g is a film 40 having concavities and convexities formed by transferring the reverse pattern of the substrate surface, and on the side 12 of the film layer is a red film 42 .
复合薄膜44的构成模拟了人体的皮肤构成。即，皮肤的最外层即表皮不具有毛细血管，因此为无色透明、乳白色且半透明、或者处于这些颜色之间的颜色。另外，形成于表皮角质层的凹凸会使射入皮肤的光发生折射、或者使其漫反射而扩散。处于表皮基底层的黑色素等吸收射入皮肤的光。进而，处于表皮内侧的真皮由于具有毛细血管而为淡红色，保持于细胞外基质的蛋白聚糖包含水分而为果冻状，因此是柔软的。通过将复合薄膜44制成与皮肤类似的构成，将皮肤遮蔽材料2g贴附于皮肤时，呈现其与皮肤的其它部分难以区分的外观，能够隐藏皮肤的异质部分而使其更不显眼。The composition of composite film 44 mimics the composition of human skin. That is, the epidermis, which is the outermost layer of the skin, does not have capillaries, so it is colorless and transparent, milky white and translucent, or a color between these colors. In addition, the unevenness formed in the stratum corneum of the epidermis refracts or diffuses light incident on the skin to diffuse it. Melanin and the like in the basal layer of the epidermis absorb light incident on the skin. Furthermore, the dermis inside the epidermis is light red because it has capillaries, and the proteoglycan held in the extracellular matrix contains water and is jelly-like, so it is soft. By making the composite film 44 similar to the skin, when the skin masking material 2g is attached to the skin, it presents an appearance indistinguishable from other parts of the skin, which can hide the heterogeneous parts of the skin and make it less conspicuous.
图4所示的皮肤遮蔽材料2h具备贴合并层叠于粘合剂层6a的皮肤接触面16的粘合剂保护部18。作为粘合剂保护部18，可列举出具有刚性的聚对苯二甲酸乙二醇酯等薄膜、以实施了有机硅处理的纸作为原材料的剥离纸19。通过该构成，在直至使用者即将贴附之前剥掉粘合剂保护部18为止，对皮肤接触面16进行保护。另外，粘合剂保护部18作为支承体而发挥功能，因此，在制造时、使用者携带时，皮肤遮蔽材料2h的处理变得容易。The skin masking material 2h shown in FIG. 4 is provided with the adhesive protection part 18 bonded and laminated|stacked on the skin contact surface 16 of the adhesive layer 6a. Examples of the adhesive protection portion 18 include rigid films such as polyethylene terephthalate and release paper 19 made of silicone-treated paper. With this configuration, the skin contact surface 16 is protected until the user peels off the adhesive protection portion 18 immediately before sticking. Moreover, since the adhesive protection part 18 functions as a support body, handling of the skin masking material 2h becomes easy at the time of manufacture and when a user carries it.
剥离纸19设置有切口20。粘合剂保护部18包含被切口20断开的2片剥离纸19。粘合剂保护部18具备：在切口20处翻折剥离纸19而成的翻折部22、以及在翻折部22上进一步重叠剥离纸19而成的摘取部23。使用者用指尖摘取翻折部22或摘取部23时，能够容易地剥掉剥离纸19。The release paper 19 is provided with cutouts 20 . The adhesive protector 18 includes two release papers 19 separated by the slit 20 . The adhesive protector 18 includes a folded portion 22 formed by folding the release paper 19 at the cutout 20 , and a pick-up portion 23 formed by further stacking the release paper 19 on the folded portion 22 . The release paper 19 can be easily peeled off when the user picks the folded-back portion 22 or the pick-off portion 23 with fingertips.
皮肤遮蔽材料2h具备贴合并层叠于薄膜层4a的另一面(10a、10b)的凹凸保护部24。凹凸保护部24设置有：具有刚性的塑料制薄膜25、以及在塑料制薄膜25的单面薄薄地涂布粘合剂而成的弱粘合剂层26。凹凸保护部24在制造时作为支承体而发挥功能，因此，能在向皮肤接触面16贴合并层叠粘合剂保护部18的工序中抑制层叠体14的变形而便于制造。另外，其保护另一面(10a、10b)直至使用者剥掉凹凸保护部24为止。能够避免在贴附于皮肤时层叠体14下垂而导致皮肤接触面16彼此粘接，能够避免层叠体14在产生褶皱的情况下被贴附。The skin masking material 2h is equipped with the unevenness|corrugation protection part 24 bonded and laminated|stacked on the other surface (10a, 10b) of the film layer 4a. The concave-convex protection portion 24 is provided with a rigid plastic film 25 and a weak adhesive layer 26 in which an adhesive is thinly applied to one side of the plastic film 25 . Since the concave-convex protection part 24 functions as a support during manufacture, deformation of the laminated body 14 can be suppressed in the process of attaching and laminating the adhesive protection part 18 to the skin contact surface 16 to facilitate manufacture. In addition, it protects the other surface ( 10 a , 10 b ) until the user peels off the concave-convex protection portion 24 . It is possible to prevent the skin-contacting surfaces 16 from sticking to each other due to sagging of the laminated body 14 when it is attached to the skin, and it is possible to prevent the laminated body 14 from being attached with wrinkles.
设置于凹凸保护部24的塑料制薄膜25、弱粘合剂层26具有切口28。凹凸保护部24设置有被切口28断开的2片塑料制薄膜25和弱粘合剂层26。凹凸保护部24设置有重叠在切口28上的摘取部29。凹凸保护部24的摘取部29具有薄膜30和在薄膜30的单面的一部分涂布粘合剂而成的粘合剂层31。摘取部29的粘合剂层31以与位于切口28两侧的塑料制薄膜25粘接的方式进行层叠。以摘取部29的粘合剂层31的粘合力强于弱粘合剂层26的方式调整其粘合剂的组成、涂布量。需要说明的是，摘取部29的薄膜30的形状、摘取部29的粘合剂层31的形状、粘合剂层31与位于切口28两侧的塑料制薄膜25、摘取部29的薄膜30层叠的位置等不限定于图4的例示。The plastic film 25 and the weak adhesive layer 26 provided on the unevenness protection part 24 have cutouts 28 . The concave-convex protection portion 24 is provided with two plastic films 25 and a weak adhesive layer 26 separated by a cutout 28 . The unevenness protecting portion 24 is provided with a pick-off portion 29 superimposed on the cutout 28 . The extraction part 29 of the uneven|corrugated protection part 24 has the film 30 and the adhesive layer 31 which apply|coated the adhesive to a part of one surface of the film 30. As shown in FIG. The adhesive layer 31 of the extraction part 29 is laminated|stacked so that it may adhere|attach to the plastic film 25 located in both sides of the cutout 28. As shown in FIG. The composition and application amount of the adhesive are adjusted so that the adhesive force of the adhesive layer 31 of the extraction portion 29 is stronger than that of the weak adhesive layer 26 . It should be noted that the shape of the film 30 of the picking portion 29, the shape of the adhesive layer 31 of the picking portion 29, the relationship between the adhesive layer 31 and the plastic film 25 positioned at both sides of the cutout 28, and the picking portion 29 The position where the thin film 30 is stacked and the like are not limited to those illustrated in FIG. 4 .
在凹凸保护部24设置有切口28和摘取部29时，与弱粘合剂层26的粘合力相比，摘取部29的粘合剂层31的粘合力更强，因此，拉拽摘取部29的薄膜30时，塑料制薄膜25、弱粘合剂层26也被拉拽而变形。另外，凹凸保护部24具有切口28，因此，在变形时从切口28向弱粘合剂层26与另一面(10a、10b)之间进入空气，弱粘合剂层26从另一面(10a、10b)被剥离。因此，皮肤遮蔽材料2h贴附于面部时，若用指尖摘取摘取部29，则使用者即使不照镜子也能够基于指尖的触感而容易地剥掉凹凸保护部24的整体。When the concave-convex protection part 24 is provided with the notch 28 and the picking part 29, compared with the adhesive force of the weak adhesive layer 26, the adhesive force of the adhesive layer 31 of the picking part 29 is stronger, so the pull When the film 30 of the pick-up part 29 is pulled, the plastic film 25 and the weak adhesive layer 26 are also pulled and deformed. In addition, the concavo-convex protection part 24 has a slit 28, so air enters between the weak adhesive layer 26 and the other surface (10a, 10b) from the slit 28 during deformation, and the weak adhesive layer 26 enters from the other surface (10a, 10b). 10b) is stripped. Therefore, when the skin masking material 2h is attached to the face, if the pick-off portion 29 is picked with fingertips, the user can easily peel off the entire unevenness protection portion 24 based on the touch of the fingertips without looking in a mirror.
粘合剂保护部18的切口20与凹凸保护部24的切口28设置于不重叠的位置。例如，粘合剂保护部18的切口设置于粘合剂层6的皮肤接触面16的端部，凹凸保护部24的切口28设置于薄膜层4的另一面10的中央部。粘合剂保护部18与凹凸保护部24的切口(20、28)位置不同时，能够避免皮肤遮蔽材料2h的预料不到的弯曲而粘合剂保护部18或凹凸保护部24发生脱离。另外，能够避免贴附于皮肤时误将薄膜层4a的另一面(10a、10b)与粘合剂层6a的皮肤接触面16的朝向弄反来操作。The notch 20 of the adhesive protection part 18 and the notch 28 of the unevenness|corrugation protection part 24 are provided in the position which does not overlap. For example, the cutout of the adhesive protection part 18 is provided at the end of the skin contact surface 16 of the adhesive layer 6 , and the cutout 28 of the unevenness protection part 24 is provided at the center of the other surface 10 of the film layer 4 . When the positions of the cutouts ( 20 , 28 ) of the adhesive protector 18 and the uneven protector 24 are different, it is possible to prevent the adhesive protector 18 or the uneven protector 24 from detaching due to unexpected bending of the skin masking material 2 h. In addition, it can be avoided that the other surface (10a, 10b) of the film layer 4a and the skin-contacting surface 16 of the adhesive layer 6a are erroneously reversed when sticking to the skin.
图5的(a)所示的皮肤遮蔽材料2i在薄膜层4a的一面12的中央部设置有未层叠粘合剂层6i的部分33i，在一面12的边缘部层叠有粘合剂层6i。因此，皮肤遮蔽材料2i在薄膜层4a的一面12的至少一部分层叠有粘合剂层6i。皮肤遮蔽材料2i的部分33i处没有粘合剂层6i，因此，透湿度高。另外，能够通过层叠于一面12的边缘部的粘合剂层6i来防止贴附皮肤遮蔽材料2i后因具有部分33i而发生的薄膜层4a卷起。需要说明的是，部分33i可以嵌入不具有粘合性的保持材料。保持材料优选包含药效成分。The skin masking material 2i shown in (a) of FIG. Therefore, the skin masking material 2i is laminated with the adhesive layer 6i on at least a part of one side 12 of the film layer 4a. There is no adhesive layer 6i at the portion 33i of the skin masking material 2i, and therefore, the moisture permeability is high. In addition, the adhesive layer 6i laminated on the edge of the one surface 12 can prevent the film layer 4a from being rolled up due to the portion 33i after the skin masking material 2i is attached. It should be noted that the portion 33i may be embedded in a non-adhesive holding material. The holding material preferably contains medicinal ingredients.
图5的(b)、(c)所示的皮肤遮蔽材料2j在一面12的中央部设置有未层叠粘合剂层6j的部分33j和格子状的粘合剂层32，在一面12的边缘部层叠有粘合剂层6j。因此，皮肤遮蔽材料2j在薄膜层4a的一面12的至少一部分层叠有粘合剂层(6j、32)。皮肤遮蔽材料2j在具有与皮肤遮蔽材料2i相同的作用效果的基础上，能够防止贴附于皮肤后因格子状的粘合剂层32而导致薄膜层4a的中央部浮起。The skin masking material 2j shown in (b) and (c) of FIG. The adhesive layer 6j is laminated on the upper part. Therefore, the skin masking material 2j is laminated with an adhesive layer (6j, 32) on at least a part of one surface 12 of the film layer 4a. The skin masking material 2j has the same effect as the skin masking material 2i, and can prevent the central part of the film layer 4a from floating due to the grid-shaped adhesive layer 32 after being attached to the skin.
作为皮肤遮蔽材料(2i、2j)的制造方法，例如可列举出如下方法：代替在前述皮肤遮蔽材料(2a、2b)的制造方法中将薄膜M贴附于粘合剂片材N，将成为粘合剂层(6i、6j、32)原料的粘合剂丝网印刷于薄膜M的一面。As a method for producing the skin-masking material (2i, 2j), for example, a method that replaces attaching the film M to the adhesive sheet N in the method for producing the skin-masking material (2a, 2b) described above, a method that becomes The adhesive of adhesive layer (6i, 6j, 32) raw material is screen-printed on one side of film M.
图1～3、5所示的皮肤遮蔽材料(2a、2b、2f、2g、2i、2j)可以如图4所示的皮肤遮蔽材料2h那样，具备粘合剂保护部18、凹凸保护部24。另外，图1～4所示的皮肤遮蔽材料(2a、2b、2f、2g、2h)可以如图5所示的皮肤遮蔽材料(2i、2j)那样，具备未层叠粘合剂层(6i、6j)的部分(33i、33j)、格子状的粘合剂层32。The skin masking material (2a, 2b, 2f, 2g, 2i, 2j) shown in FIGS. . In addition, the skin masking materials (2a, 2b, 2f, 2g, 2h) shown in Figures 1 to 4 can be equipped with non-laminated adhesive layers (6i, 6j) part (33i, 33j), the lattice-shaped adhesive layer 32.
[实施例1][Example 1]
作为流延用剥离性基板，准备在表面具有人工皮革的表皮样凹凸的反转图案的基板。该基板的表面的Rz为10μm。另外，作为氨酯树脂溶液，准备了レオコートU-6285M(固体成分为30重量％)(Toray Coatex Co.,Ltd.制)。作为微粒，准备了平均粒径为4μm的二氧化硅粉末2.5重量份、红色颜料0.2重量份、氧化钛0.15重量份和合成云母10重量份。将这些微粒添加于聚乙二醇、醋酸乙酯、乳化剂的混合液并使其分散来制备溶液，将该溶液混合至氨酯树脂溶液87重量份中。As a peelable substrate for casting, a substrate having a reversed pattern of skin-like irregularities of artificial leather on the surface was prepared. Rz of the surface of this substrate was 10 μm. In addition, Leocoat U-6285M (solid content: 30% by weight) (manufactured by Toray Coatex Co., Ltd.) was prepared as a urethane resin solution. As fine particles, 2.5 parts by weight of silica powder having an average particle diameter of 4 μm, 0.2 parts by weight of a red pigment, 0.15 parts by weight of titanium oxide, and 10 parts by weight of synthetic mica were prepared. These fine particles were added to a mixed liquid of polyethylene glycol, ethyl acetate, and an emulsifier and dispersed to prepare a solution, and this solution was mixed with 87 parts by weight of a urethane resin solution.
将混合有微粒的氨酯树脂溶液流延至基板的表面并干燥，将干燥物从基板上剥离而得到支承体S。在使氨酯树脂溶液干燥的过程中，醋酸乙酯等溶剂发生气化，因此，干燥后得到的支承体S实质上不残留溶剂。支承体S的薄膜厚度为30μm。支承体S的薄膜的另一面(转印面)转印有反转图案，另一面的Rz为10μm。另外，另一面形成有深度为5～10μm且直径为5～20μm的多个孔、以及深度为5～25μm且宽度为5～25μm的多个槽。另一方面，支承体S的薄膜的一面(不是转印面的面)未接触流延用剥离性基板，因此是平滑的。The urethane resin solution mixed with fine particles was cast on the surface of the substrate, dried, and the dried product was peeled off from the substrate to obtain a support S. In the process of drying the urethane resin solution, solvents such as ethyl acetate are vaporized, and therefore, the support S obtained after drying substantially does not remain a solvent. The film thickness of the support S was 30 μm. The reverse pattern was transferred to the other surface (transfer surface) of the film of the support body S, and Rz of the other surface was 10 micrometers. In addition, a plurality of holes having a depth of 5 to 10 μm and a diameter of 5 to 20 μm, and a plurality of grooves having a depth of 5 to 25 μm and a width of 5 to 25 μm are formed on the other surface. On the other hand, the surface of the film of the support S (the surface other than the transfer surface) is not in contact with the release substrate for casting, so it is smooth.
作为丙烯酸系粘合剂的主要成分液，将丙烯酸2-乙基己酯(2-EHA)、丙烯酸甲氧基乙酯(MEA)、丙烯酸(AA)以重量比计为68:25:7的比率混合溶解于醋酸乙酯，添加聚合引发剂偶氮双异丁腈(AIBN)0.3重量份，以60～65℃使其共聚，从而制备包含粘合性高分子化合物的溶液。该主要成分液中，因共聚而产生的粘合性高分子化合物的固体成分占40重量％。向该主要成分液175重量份中添加单油酸山梨糖醇酐酯30重量份、作为抗氧化剂的二丁基羟基甲苯(BHT)0.07重量份和用于固化的异氰酸酯系交联剂溶液(固体成分约为60重量％)3.5重量份，从而制备流延用溶液。将该流延用溶液流延在剥离片材上并干燥，从而得到粘合剂片材T。在使流延用溶液干燥的过程中，醋酸乙酯等溶剂发生气化，因此，干燥后得到的粘合剂片材T实质上不残留溶剂。粘合剂片材T的粘合剂层的厚度为15μm。As the main component liquid of the acrylic adhesive, 2-ethylhexyl acrylate (2-EHA), methoxyethyl acrylate (MEA), and acrylic acid (AA) were used in a weight ratio of 68:25:7. Ratio mixing and dissolving in ethyl acetate, adding 0.3 parts by weight of azobisisobutyronitrile (AIBN) as a polymerization initiator, and copolymerizing at 60 to 65°C to prepare a solution containing an adhesive polymer compound. In this main component liquid, the solid content of the adhesive polymer compound produced by copolymerization accounted for 40% by weight. To 175 parts by weight of the main component liquid, 30 parts by weight of sorbitan monooleate, 0.07 parts by weight of dibutylhydroxytoluene (BHT) as an antioxidant, and an isocyanate-based crosslinking agent solution (solid Components are about 60% by weight) 3.5 parts by weight to prepare a solution for casting. This casting solution was cast on a release sheet and dried to obtain an adhesive sheet T. In the process of drying the casting solution, solvents such as ethyl acetate are vaporized, and therefore, the adhesive sheet T obtained after drying substantially does not remain a solvent. The thickness of the adhesive layer of the adhesive sheet T was 15 μm.
将支承体S的薄膜的一面(不是转印面的面)载置在粘合剂片材T的不带有剥离片材的面上，得到S与T与剥离片材的层叠物。从该层叠物上剥掉剥离片材，置换成具备切口、翻折部和摘取部的剥离纸。其后，在S的另一面(转印面)上贴附层叠有薄粘合剂层的塑料制薄膜，以不损伤S的薄膜的方式通过半切割加工对塑料制薄膜和弱粘合剂层切入切口。最后，用刀具从贴附有塑料制薄膜的一侧将塑料制薄膜与S与T与剥离纸的层叠物冲切成直径15mm的圆形。将由此得到的直径15mm的圆形层叠物作为皮肤遮蔽材料的样品。One side of the film of the support S (the side other than the transfer side) was placed on the side of the adhesive sheet T without the release sheet to obtain a laminate of S, T, and the release sheet. The release sheet was peeled off from this laminate, and replaced with a release paper provided with a notch, a fold-back portion, and a pick-up portion. After that, stick a plastic film laminated with a thin adhesive layer on the other side (transfer surface) of S, and cut the plastic film and the weak adhesive layer by half-cutting so as not to damage the film of S. incision. Finally, the laminate of the plastic film, S and T, and release paper was die-cut into a circular shape with a diameter of 15 mm from the side to which the plastic film was stuck. The circular laminate having a diameter of 15 mm thus obtained was used as a sample of the skin masking material.
[实施例2][Example 2]
通过实施例1制备薄膜时，作为流延用剥离性基板，使用表面的Rz为6μm的基板。除此之外，利用与实施例1相同的条件制备实施例2的皮肤遮蔽材料2的样品。When preparing a thin film according to Example 1, a substrate having a surface Rz of 6 μm was used as a release substrate for casting. Except for this, a sample of the skin masking material 2 of Example 2 was prepared under the same conditions as in Example 1.
通过实施例2制备的样品中，薄膜的另一面(转印面)转印有反转图案，薄膜的另一面的Rz为6μm。另外，另一面形成有深度为3～7μm且直径为3～20μm的多个孔、以及深度为3～12μm且宽度为3～25μm的多个槽。In the sample prepared in Example 2, the reverse pattern was transferred on the other side (transfer side) of the film, and the Rz of the other side of the film was 6 μm. In addition, a plurality of holes having a depth of 3 to 7 μm and a diameter of 3 to 20 μm, and a plurality of grooves having a depth of 3 to 12 μm and a width of 3 to 25 μm are formed on the other surface.
[实施例3][Example 3]
通过实施例1制备薄膜时，作为流延用剥离性基板，使用表面的Rz为18μm的基板。除此之外，利用与实施例1相同的条件制备实施例3的皮肤遮蔽材料的样品。When preparing a thin film according to Example 1, a substrate having a surface Rz of 18 μm was used as a release substrate for casting. Except for this, a sample of the skin masking material of Example 3 was prepared under the same conditions as in Example 1.
通过实施例3制备的样品中，薄膜的另一面(转印面)转印有反转图案。薄膜的另一面的Rz为18μm，Ra为9μm。另外，另一面形成有深度为5～18μm且直径为5～20μm的多个孔、以及深度为5～15μm且宽度为5～15μm的多个槽。In the sample prepared by Example 3, the reverse pattern was transferred on the other side (transfer side) of the film. On the other side of the film, Rz was 18 μm, and Ra was 9 μm. In addition, a plurality of holes having a depth of 5 to 18 μm and a diameter of 5 to 20 μm, and a plurality of grooves having a depth of 5 to 15 μm and a width of 5 to 15 μm are formed on the other surface.
[实施例4][Example 4]
向通过实施例1制备的丙烯酸系粘合剂的主要成分液175重量份中添加单油酸山梨糖醇酐酯30重量份、作为抗氧化剂的二丁基羟基甲苯(BHT)0.07重量份、乳酸2.1重量份和异氰酸酯系交联剂溶液(固体成分约为60重量％)3.5重量份，制备流延用溶液。除此之外，利用与实施例1相同的条件制备实施例4的皮肤遮蔽材料的样品。To 175 parts by weight of the main component liquid of the acrylic adhesive prepared in Example 1, 30 parts by weight of sorbitan monooleate, 0.07 parts by weight of dibutylhydroxytoluene (BHT) as an antioxidant, and lactic acid 2.1 parts by weight and 3.5 parts by weight of an isocyanate-based crosslinking agent solution (solid content: about 60% by weight) were used to prepare a solution for casting. Except for this, a sample of the skin masking material of Example 4 was prepared under the same conditions as in Example 1.
[实施例5][Example 5]
通过实施例1制备粘合剂时，作为丙烯酸系粘合剂的主要成分液，将丙烯酸2-乙基己酯(2-EHA)、丙烯酸甲氧基乙酯(MEA)、羟基乙基丙烯酰胺(HEAA)以重量比计为68:25:7的比率混合溶解于醋酸乙酯，进一步添加聚合引发剂偶氮双异丁腈(AIBN)0.3重量份，以60～65℃使其共聚，从而制备包含粘合性高分子化合物的溶液。该主要成分液中，因共聚而产生的粘合性高分子化合物的固体成分占40重量％。向该主要成分液175重量份中添加单油酸山梨糖醇酐酯30重量份、作为抗氧化剂的二丁基羟基甲苯(BHT)0.07重量份和用于固化的异氰酸酯系交联剂溶液(固体成分约为60重量％)1.4重量份，从而制备流延用溶液。将该流延用溶液流延在剥离片材上并干燥，从而得到粘合剂片材U。除此之外，利用与实施例1相同的条件制备实施例5的皮肤遮蔽材料的样品。When preparing the adhesive in Example 1, as the main component liquid of the acrylic adhesive, 2-ethylhexyl acrylate (2-EHA), methoxyethyl acrylate (MEA), hydroxyethylacrylamide (HEAA) is mixed and dissolved in ethyl acetate at a ratio of 68:25:7 by weight, and 0.3 parts by weight of the polymerization initiator azobisisobutyronitrile (AIBN) is further added, and it is copolymerized at 60-65°C, thereby A solution containing an adhesive polymer compound is prepared. In this main component liquid, the solid content of the adhesive polymer compound produced by copolymerization accounted for 40% by weight. To 175 parts by weight of the main component liquid, 30 parts by weight of sorbitan monooleate, 0.07 parts by weight of dibutylhydroxytoluene (BHT) as an antioxidant, and an isocyanate-based crosslinking agent solution (solid Components are about 60% by weight) 1.4 parts by weight to prepare a solution for casting. This casting solution was cast on a release sheet and dried to obtain an adhesive sheet U. Except for this, a sample of the skin masking material of Example 5 was prepared under the same conditions as in Example 1.
[实施例6][Example 6]
通过实施例4制备薄膜时，作为流延用剥离性基板，使用表面的Rz为25μm的基板。因此，通过实施例6制备的薄膜中，另一面(转印面)的Rz为25μm。另外，代替通过实施例4制备流延用溶液时的乳酸2.1重量份而添加水杨酸2.1重量份。除此之外，利用与实施例4相同的条件制备实施例6的皮肤遮蔽材料的样品。When preparing a thin film in Example 4, a substrate having a surface Rz of 25 μm was used as a release substrate for casting. Therefore, in the film prepared in Example 6, the Rz of the other side (transfer side) was 25 μm. In addition, 2.1 parts by weight of salicylic acid was added instead of 2.1 parts by weight of lactic acid when the solution for casting was prepared in Example 4. Except for this, a sample of the skin masking material of Example 6 was prepared under the same conditions as in Example 4.
[实施例7][Example 7]
代替通过实施例6制备流延用溶液时的水杨酸2.1重量份，添加羟基乙酸2.1重量份，进一步添加作为抗菌剂的异丙基甲基苯酚0.2重量份。除此之外，利用与实施例6相同的条件制备实施例7的皮肤遮蔽材料的样品。Instead of 2.1 parts by weight of salicylic acid when preparing the casting solution in Example 6, 2.1 parts by weight of glycolic acid was added, and 0.2 parts by weight of isopropylmethylphenol was further added as an antibacterial agent. Except for this, a sample of the skin masking material of Example 7 was prepared under the same conditions as in Example 6.
[实施例8][Example 8]
通过实施例1制备薄膜时，作为流延用剥离性基板，使用表面的Rz为25μm的基板。通过实施例8制备的薄膜的另一面(转印面)的Rz为25μm。When preparing a thin film according to Example 1, a substrate having a surface Rz of 25 μm was used as a release substrate for casting. The Rz of the other side (transfer side) of the film prepared in Example 8 was 25 μm.
作为丙烯酸类树脂系粘合剂的主要成分液，将丙烯酸2-乙基己酯(2-EHA)、醋酸乙烯酯(VA)、丙烯酸羟基乙酯(HEA)以重量比计为68:25:7的比率混合溶解于醋酸乙酯，添加聚合引发剂偶氮双异丁腈(AIBN)0.3重量％，以60～65℃使其共聚，从而制备包含粘合性高分子化合物的溶液。该主要成分液中，因共聚而产生的粘合性高分子化合物的固体成分占40重量％。向该主要成分液95重量份中混合甲基丙烯酸丁酯、甲基丙烯酸甲酯和甲基丙烯酸二甲氨基乙酯的共聚物5重量份，进一步添加醋酸乙酯，以固体成分占40重量％的方式进行调整而制备组合物的溶液。向该组合物的溶液175重量份中添加作为抗炎药的皮考布洛芬3.5重量份、作为抗菌剂的异丙基甲基苯酚0.2重量份、单油酸山梨糖醇酐酯3.5重量份、肉豆蔻酸异丙酯(IPM)7重量份、丁二醇3.5重量份、乳酸7重量份、作为抗氧化剂的二丁基羟基甲苯(BHT)0.07重量份和用于固化的经封端化的异氰酸酯系交联剂溶液(固体成分约为30重量％)3.5重量份，从而制备流延用溶液。除此之外，利用与实施例1相同的条件制备实施例8的皮肤遮蔽材料的样品。As the main component liquid of the acrylic resin adhesive, 2-ethylhexyl acrylate (2-EHA), vinyl acetate (VA), and hydroxyethyl acrylate (HEA) are calculated as 68:25 by weight: A ratio of 7 was mixed and dissolved in ethyl acetate, 0.3% by weight of azobisisobutyronitrile (AIBN) was added as a polymerization initiator, and copolymerized at 60 to 65°C to prepare a solution containing an adhesive polymer compound. In this main component liquid, the solid content of the adhesive polymer compound produced by copolymerization accounted for 40% by weight. 5 parts by weight of a copolymer of butyl methacrylate, methyl methacrylate and dimethylaminoethyl methacrylate was mixed with 95 parts by weight of the main component liquid, and ethyl acetate was further added to make the solid content 40% by weight. A solution of the composition is prepared by adjusting in a manner. 3.5 parts by weight of picobuprofen as an anti-inflammatory agent, 0.2 parts by weight of isopropylmethylphenol as an antibacterial agent, and 3.5 parts by weight of sorbitan monooleate were added to 175 parts by weight of a solution of this composition , 7 parts by weight of isopropyl myristate (IPM), 3.5 parts by weight of butanediol, 7 parts by weight of lactic acid, 0.07 parts by weight of dibutylhydroxytoluene (BHT) as an antioxidant, and end-capped 3.5 parts by weight of isocyanate-based crosslinking agent solution (solid content: about 30% by weight) to prepare a solution for casting. Except for this, a sample of the skin masking material of Example 8 was prepared under the same conditions as in Example 1.
[实施例9][Example 9]
利用实施例8制备流延用溶液时，向组合物的溶液175重量份中添加作为抗炎药的皮考布洛芬3.5重量份、作为抗菌剂的异丙基甲基苯酚0.2重量份、单油酸山梨糖醇酐酯3.5重量份、肉豆蔻酸异丙酯(IPM)7重量份、丁二醇3.5重量份、乳酸7重量份、作为抗氧化剂的二丁基羟基甲苯(BHT)0.07重量份和用于固化的异氰酸酯系交联剂溶液(固体成分约为60重量％)1.3重量份，从而制备流延用溶液。除此之外，利用与实施例8相同的条件制备实施例9的皮肤遮蔽材料的样品。When preparing a casting solution using Example 8, 3.5 parts by weight of picobuprofen as an anti-inflammatory agent, 0.2 parts by weight of isopropylmethylphenol as an antibacterial agent, and 175 parts by weight of a solution of the composition were added. 3.5 parts by weight of sorbitan oleate, 7 parts by weight of isopropyl myristate (IPM), 3.5 parts by weight of butylene glycol, 7 parts by weight of lactic acid, 0.07 parts by weight of dibutylhydroxytoluene (BHT) as an antioxidant and 1.3 parts by weight of an isocyanate-based crosslinking agent solution (solid content about 60% by weight) for curing to prepare a solution for casting. Except for this, a sample of the skin masking material of Example 9 was prepared under the same conditions as in Example 8.
[实施例10][Example 10]
通过实施例1制备薄膜时，作为流延用剥离性基板，使用表面的Rz为25μm的基板。通过实施例10制备的薄膜中，另一面(转印面)的Rz为25μm。When preparing a thin film according to Example 1, a substrate having a surface Rz of 25 μm was used as a release substrate for casting. In the film prepared in Example 10, the Rz of the other side (transfer side) was 25 μm.
通过实施例1制备流延用溶液时，向丙烯酸类树脂系粘合剂的主要成分液175重量份中添加作为抗炎药的皮考布洛芬3.5重量份、作为抗菌剂的异丙基甲基苯酚0.2重量份、单油酸山梨糖醇酐酯3.5重量份、肉豆蔻酸异丙酯(IPM)7重量份、丁二醇3.5重量份和乳酸7重量份、作为抗氧化剂的二丁基羟基甲苯(BHT)0.07重量份和用于固化的异氰酸酯系交联剂溶液(固体成分约为60重量％)3.5重量份，从而制备流延用溶液。除此之外，利用与实施例1相同的条件制备实施例10的皮肤遮蔽材料的样品。When preparing a casting solution according to Example 1, 3.5 parts by weight of picobuprofen as an anti-inflammatory drug and 3.5 parts by weight of isopropylmethanol as an antibacterial agent were added to 175 parts by weight of the main component liquid of the acrylic resin adhesive. 0.2 parts by weight of phenol, 3.5 parts by weight of sorbitan monooleate, 7 parts by weight of isopropyl myristate (IPM), 3.5 parts by weight of butanediol and 7 parts by weight of lactic acid, dibutyl 0.07 parts by weight of hydroxytoluene (BHT) and 3.5 parts by weight of an isocyanate-based crosslinking agent solution (solid content: about 60% by weight) for curing were used to prepare a solution for casting. Except for this, a sample of the skin masking material of Example 10 was prepared under the same conditions as in Example 1.
[比较例1][Comparative example 1]
通过实施例1制备薄膜时，作为流延用剥离性基板，使用了以往用于制造氨酯薄膜的OPP薄膜的基板。该基板的表面是平滑的OPP制脱模用纸。薄膜的另一面(转印面)转印有OPP制剥离用纸表面的凹凸，薄膜的另一面的Rz为0.9μm。除此之外，利用与实施例1相同的条件制备比较例1的皮肤遮蔽材料的样品。When preparing a film in Example 1, a substrate of an OPP film conventionally used for producing a urethane film was used as a release substrate for casting. The surface of this board|substrate was smooth release paper made from OPP. On the other side (transfer side) of the film, the irregularities on the surface of the OPP release paper were transferred, and the Rz of the other side of the film was 0.9 μm. Except for this, a sample of the skin masking material of Comparative Example 1 was prepared under the same conditions as in Example 1.
[比较例2][Comparative example 2]
通过实施例1制备薄膜时，作为流延用剥离性基板，使用表面的Rz为3μm的基板。另外，作为氨酯树脂溶液，使用了将レオコートU-6285M(固体成分为30重量％)(Toray CoatexCo.,Ltd.制)100重量份与醋酸乙酯100重量份混合而成的溶液。该氨酯树脂溶液中未添加微粒。薄膜的另一面(转印面)的Rz为3μm。除此之外，利用与实施例1相同的条件制备比较例2的皮肤遮蔽材料的样品。When preparing a thin film according to Example 1, a substrate having a surface Rz of 3 μm was used as a release substrate for casting. In addition, as the urethane resin solution, a solution obtained by mixing 100 parts by weight of Leocoat U-6285M (solid content: 30% by weight) (manufactured by Toray Coatex Co., Ltd.) and 100 parts by weight of ethyl acetate was used. No fine particles were added to this urethane resin solution. The Rz of the other surface (transfer surface) of the film was 3 μm. Except for this, a sample of the skin masking material of Comparative Example 2 was prepared under the same conditions as in Example 1.
[比较例3][Comparative example 3]
通过实施例1制备薄膜时，作为流延用剥离性基板，使用表面的Rz为10μm的基板。另外，准备聚乙烯树脂的粒料来代替实施例1中使用的氨酯树脂溶液。向该聚乙烯树脂26.1重量份中以相同的份量混炼与实施例1的种类相同的微粒。将混炼有微粒的聚乙烯树脂挤出在流延用剥离性基板的表面，从基板剥离而得到支承体X。薄膜的另一面(转印面)的Rz为5μm。除此之外，利用与实施例1相同的条件制备比较例3的皮肤遮蔽材料的样品。When preparing a thin film in Example 1, a substrate having a surface Rz of 10 μm was used as a release substrate for casting. In addition, instead of the urethane resin solution used in Example 1, pellets of polyethylene resin were prepared. The same kind of microparticles as in Example 1 were kneaded in the same amount in 26.1 parts by weight of the polyethylene resin. The polyethylene resin kneaded with fine particles was extruded onto the surface of a release substrate for casting, and peeled from the substrate to obtain a support X. The Rz of the other side (transfer side) of the film was 5 μm. Except for this, a sample of the skin masking material of Comparative Example 3 was prepared under the same conditions as in Example 1.
[实施例、比较例中的薄膜层的另一面的Rz值的计算方法][Calculation method of Rz value on the other side of the film layer in Examples and Comparative Examples]
针对实施例、比较例的皮肤遮蔽材料的样品，薄膜层的另一面的Rz值通过如下方法来计算。For the skin masking material samples of Examples and Comparative Examples, the Rz value on the other side of the film layer was calculated by the following method.
(1)针对样品的另一面上的任意部位，按照JIS B 0601:2001，在基准长度500μm、取样长度200μm的条件下使用表面粗糙度测定机，测定该部位的表面形状，从而得到该部位的Rz值。(1) For any part on the other side of the sample, according to JIS B 0601:2001, use a surface roughness measuring machine under the conditions of a reference length of 500 μm and a sampling length of 200 μm to measure the surface shape of the part to obtain the surface shape of the part. Rz value.
(2)在另一面上的20处重复(1)的操作，得到20处的Rz值。(2) Repeat the operation of (1) at 20 places on the other surface to obtain the Rz value at 20 places.
(3)将20处的Rz值的平均值作为样品的薄膜层的另一面的Rz值。(3) Let the average value of the Rz values at 20 points be the Rz value on the other side of the thin film layer of the sample.
[实施例、比较例的特性值等][Property values of Examples and Comparative Examples, etc.]
针对实施例、比较例中得到的皮肤遮蔽材料的样品，将薄膜层和皮肤遮蔽材料的特性值等示于表1。Table 1 shows the film layer and the characteristic values of the skin-masking material for the samples of the skin-masking material obtained in Examples and Comparative Examples.
[表1][Table 1]
[对制造方法与另一面的Rz的关系进行研究][Research on the relationship between the manufacturing method and Rz on the other side]
在试制样品时，实施例1中，将聚醚聚氨酯(EU)树脂溶液流延至Rz为10μm的流延用剥离性基板的表面而进行了试制。实施例1中，薄膜层的另一面转印有基板表面的凹凸，如表1所示那样，该另一面的Rz达到10μm。另一方面，比较例3中，将熔融的聚乙烯(PE)树脂挤出在Rz为10μm的流延用剥离性基板的表面而进行了试制。此时，比较例1中的另一面的Rz达到5μm。When producing a trial sample, in Example 1, a polyether urethane (EU) resin solution was cast onto the surface of a release substrate for casting whose Rz was 10 μm. In Example 1, the unevenness of the substrate surface was transferred to the other surface of the thin film layer, and as shown in Table 1, the Rz of the other surface reached 10 μm. On the other hand, in Comparative Example 3, a trial production was carried out by extruding molten polyethylene (PE) resin on the surface of a release substrate for casting whose Rz was 10 μm. At this time, the Rz of the other surface in Comparative Example 1 reached 5 μm.
比较例3中，使用与实施例1同样的流延用剥离性基板，但基板表面的凹凸未充分地转印至薄膜的另一面。因此，比较例3的样品中，形成于其另一面的凹凸带有弧度，另一面容易打滑。可以认为：比较例3中未充分转印有基板表面的凹凸的原因在于，将熔融的聚乙烯(PE)树脂挤出在基板表面时，该树脂不是流动性良好的液体。制造本发明的皮肤遮蔽材料时，与将熔融的树脂挤出在基板表面相比，将树脂溶液流延至基板表面而进行制造对于制造另一面的Rz值大的皮肤遮蔽材料而言是更适合的。In Comparative Example 3, the same release substrate for casting as in Example 1 was used, but the irregularities on the surface of the substrate were not sufficiently transferred to the other surface of the film. Therefore, in the sample of Comparative Example 3, the unevenness formed on the other surface was curved, and the other surface was easily slippery. It is considered that the unevenness of the substrate surface was not sufficiently transferred in Comparative Example 3 because the molten polyethylene (PE) resin was not a fluid liquid when extruded onto the substrate surface. When producing the skin-masking material of the present invention, it is more suitable for producing a skin-masking material with a large Rz value on the other side than extruding molten resin onto the surface of the substrate. .
[对另一面的Rz与透湿度的关系进行研究][Study on the relationship between Rz and moisture permeability on the other side]
实施例1～3的薄膜层的树脂和粘合剂层的原材料是相同的，但另一面的Rz各不相同。实施例1～3表明了，Rz值越大，皮肤遮蔽材料的透湿度越大。The resin of the film layer and the raw material of the adhesive layer in Examples 1 to 3 are the same, but the Rz of the other side is different. Examples 1 to 3 show that the greater the Rz value, the greater the moisture permeability of the skin masking material.
[与实施例、比较例的光学特性有关的特性值][Characteristic Values Related to Optical Properties of Examples and Comparative Examples]
将实施例、比较例中得到的皮肤遮蔽材料的样品的光学的特性值示于表2。Table 2 shows the optical characteristic values of samples of the skin shielding materials obtained in Examples and Comparative Examples.
[表2][Table 2]
[对另一面的Rz与总光线透射率的关系进行研究][Study on the relationship between Rz and total light transmittance on the other side]
实施例1～10和比较例1中，皮肤遮蔽材料的薄膜层的原材料是使组成相同的微粒以其相对于成为薄膜层原材料的薄膜重量占13.3重量％的方式分散而成的氨酯薄膜，在薄膜层的厚度w为30μm这一相同的条件下，基于另一面的Rz的尺寸差异，样品的总光线透射率产生差异。如表2所示那样，实施例1～10中，另一面的Rz为6～25μm，薄膜层的总光线透射率为86.0％～89.8％。与此相对，比较例1中，Rz为0.9μm，总光线透射率为91.1％。需要说明的是，比较例3中，将微粒以占据13.3重量％的方式进行分散且另一面的Rz为5μm的聚乙烯薄膜作为薄膜层的原材料，总光线透射率为90.6％。In Examples 1 to 10 and Comparative Example 1, the raw material of the film layer of the skin masking material is a urethane film formed by dispersing particles with the same composition in such a manner that it accounts for 13.3% by weight relative to the film weight of the film layer raw material, Under the same condition that the thickness w of the thin film layer is 30 μm, the total light transmittance of the sample varies due to the difference in the size of Rz on the other side. As shown in Table 2, in Examples 1 to 10, the Rz of the other surface was 6 to 25 μm, and the total light transmittance of the thin film layer was 86.0% to 89.8%. In contrast, in Comparative Example 1, Rz was 0.9 μm, and the total light transmittance was 91.1%. In Comparative Example 3, the total light transmittance was 90.6% using a polyethylene film in which fine particles were dispersed so as to occupy 13.3% by weight and Rz on the other side was 5 μm as a film layer material.
由另一面的Rz与薄膜层的总光线透射率的关系示出：Rz为6μm以上时，总光线透射率达到90％以下。可以认为：因Rz为6μm以上而使形成于另一面的凹凸的高低差大时，射入薄膜层的光因凹凸而大幅折射，总光线透射率降低至90％以下。反之可以认为：因Rz的值小于6μm而使形成于另一面的凹凸的高低差小时，另一面为近似平滑的形状，因此，入射光不易因凹凸而大幅折射。可以认为：为了将皮肤遮蔽材料的总光线透射率保持为90％以下，将另一面的Rz设为6μm以上是有效的。The relationship between Rz on the other side and the total light transmittance of the film layer shows that when Rz is 6 μm or more, the total light transmittance becomes 90% or less. It is considered that when the unevenness formed on the other surface has a large level difference due to Rz being 6 μm or more, the light entering the thin film layer is greatly refracted by the unevenness, and the total light transmittance decreases to 90% or less. Conversely, it can be considered that since the value of Rz is less than 6 μm, the level difference of the unevenness formed on the other surface is small, and the other surface has a nearly smooth shape, so incident light is less likely to be greatly refracted by the unevenness. It is considered that setting Rz on the other side to be 6 μm or more is effective in order to keep the total light transmittance of the skin shielding material at 90% or less.
[对微粒与总光线透射率的关系进行研究][Research on the relationship between particles and total light transmittance]
比较例1中，以相对于成为薄膜层原材料的薄膜的重量占13.3重量％的方式分散有微粒，另一面的Rz为0.9μm，总光线透射率为91.1％。另一方面，比较例2中，薄膜层中不含微粒，Rz为3μm，总光线透射率为95.9％。可以认为：比较例2尽管Rz值较大但总光线透射率仍然变高的原因在于，比较例2中不含微粒，因此不会因微粒而吸收入射光从而不会散射。可以认为：为了将皮肤遮蔽材料中的薄膜层的总光线透射率保持为90％以下，向薄膜层中分散微粒是有效的。In Comparative Example 1, fine particles were dispersed so as to account for 13.3% by weight of the film used as the material of the film layer, Rz on the other side was 0.9 μm, and the total light transmittance was 91.1%. On the other hand, in Comparative Example 2, the thin film layer contained no fine particles, Rz was 3 μm, and the total light transmittance was 95.9%. It is considered that the reason why the total light transmittance is still high in Comparative Example 2 despite the large Rz value is that since Comparative Example 2 does not contain fine particles, the incident light is not absorbed by the fine particles and is not scattered. It is considered that it is effective to disperse fine particles in the film layer in order to keep the total light transmittance of the film layer in the skin masking material at 90% or less.
[对微粒与平行光线透射率和雾度(雾值)的关系进行研究][Research on the relationship between particles and parallel light transmittance and haze (fog value)]
同样地，通过比较例1与比较例2来对比平行光线透射率和雾度(雾值)时，尽管比较例2的Rz值大，与比较例1相比，薄膜层的平行光线透射率仍然变高，薄膜层的雾度(雾值)变低。可以认为：由于比较例2的薄膜层不含微粒，因此不会产生入射光因微粒而漫反射从而扩散的作用。另一方面，以相对于成为薄膜层原材料的薄膜的重量占13.3重量％的方式分散有微粒的实施例1～10、比较例1和3中，无论Rz值如何，平行光线透射率均达到9.3～10.6％，雾度(雾值)达到87.8～89.4％。可以认为：为了将皮肤遮蔽材料中的薄膜层的平行光线透射率保持为0～12％、将薄膜层的雾度(雾值)保持为84～100％，在薄膜层中分散微粒是有效的。Similarly, when comparing parallel light transmittance and haze (haze value) through Comparative Example 1 and Comparative Example 2, although the Rz value of Comparative Example 2 is large, compared with Comparative Example 1, the parallel light transmittance of the film layer is still the same. The higher the value, the lower the haze (haze value) of the film layer. It can be considered that since the thin film layer of Comparative Example 2 does not contain particles, the effect of diffuse reflection and diffusion of incident light by the particles does not occur. On the other hand, in Examples 1 to 10 and Comparative Examples 1 and 3 in which fine particles were dispersed so as to occupy 13.3% by weight relative to the weight of the film used as the raw material of the film layer, the parallel light transmittance reached 9.3 regardless of the Rz value. ~10.6%, and the haze (fog value) reaches 87.8~89.4%. It is considered that it is effective to disperse fine particles in the film layer in order to maintain the parallel light transmittance of the film layer in the skin masking material at 0 to 12% and to maintain the haze (haze value) of the film layer at 84 to 100%. .
[实施例、比较例的粘合剂层中包含的成分][Components contained in the adhesive layers of Examples and Comparative Examples]
将实施例、比较例中得到的皮肤遮蔽材料的样品的粘合剂层中包含的针对皮肤的药效成分示于表3。另外，将粘合剂层中包含的在常温下为液体且具有极性基团的有机化合物、及其相对于粘合剂层的重量比示于表4。Table 3 shows the medicinal ingredients for the skin contained in the adhesive layers of the samples of the skin masking materials obtained in Examples and Comparative Examples. In addition, the organic compound which is liquid at normal temperature and has a polar group contained in an adhesive layer, and its weight ratio with respect to an adhesive layer are shown in Table 4.
[表3][table 3]
[表4][Table 4]
[对粘合剂层中的在常温下为液体且具有极性基团的有机化合物进行研究][Study on an organic compound that is liquid at room temperature and has a polar group in an adhesive layer]
如表4所示那样，在试制实施例和比较例的样品时，在成为粘合剂层原料的流延用溶液中，作为在常温下为液体且具有极性基团的有机化合物，相对于粘合剂层以25.6～31.2重量％的范围添加单油酸山梨糖醇酐酯等。其结果，所有的实施例和比较例的样品中，粘合剂层呈现凝胶状。As shown in Table 4, when the samples of Examples and Comparative Examples were trial-produced, in the casting solution used as the raw material of the adhesive layer, as an organic compound that is liquid at normal temperature and has a polar group, relative to To the adhesive layer, sorbitan monooleate and the like are added in a range of 25.6 to 31.2% by weight. As a result, in all the samples of Examples and Comparative Examples, the pressure-sensitive adhesive layer was gel-like.
[实施例、比较例中用于制备粘合剂层的流延用溶液的组成][Compositions of Casting Solutions Used to Prepare Adhesive Layers in Examples and Comparative Examples]
针对成为粘合剂层原材料的流延用溶液，将单体、交联剂的一部分组成示于表5。Table 5 shows some compositions of monomers and crosslinking agents for the casting solution used as the raw material of the adhesive layer.
[表5][table 5]
[对制备粘合剂层时使用的流延用溶液的组成进行研究][Study on the composition of the casting solution used in the preparation of the adhesive layer]
本发明人为了制备实施例和比较例的粘合剂层而研究了添加至流延用溶液的单体、交联剂的组成。进行研究时，针对作为粘合性高分子化合物的成为交联点的共聚单体，添加丙烯酸(AA)并使其共聚，进一步添加异氰酸酯系交联剂的情况，评价粘合剂层的粘合力、粘腻和内聚力等粘合特性。基于评价的结果研究使粘合剂层的粘合特性达到良好的交联剂的添加量时，为了使粘合剂层的粘合力处于0.1～10(N/25mm)的范围内、且使粘腻、内聚力等变得良好，需要以交联剂的固体成分相对于粘合剂层所占的重量比达到2.0重量％以上的方式大量添加交联剂。The inventors of the present invention studied the compositions of monomers and crosslinking agents added to casting solutions in order to prepare the adhesive layers of Examples and Comparative Examples. In the research, the adhesion of the adhesive layer was evaluated by adding acrylic acid (AA) to the comonomer used as the cross-linking point as the adhesive polymer compound and copolymerizing it, and further adding an isocyanate-based cross-linking agent. Adhesive properties such as strength, stickiness and cohesion. When studying the addition amount of crosslinking agent to make the adhesive properties of the adhesive layer good based on the evaluation results, in order to make the adhesive force of the adhesive layer within the range of 0.1 to 10 (N/25mm), and to make the Stickiness, cohesion, and the like become good, and it is necessary to add a large amount of the crosslinking agent so that the weight ratio of the solid content of the crosslinking agent to the adhesive layer is 2.0% by weight or more.
因此，如表5所示那样，作为实施例1～4、6、7、10和比较例1～3而制备的样品中，添加丙烯酸(AA)作为共聚单体并使其共聚，进一步以异氰酸酯系交联剂的固体成分相对于粘合剂层所占的重量比达到2.0重量％以上的组成制备粘合剂层。尽管如此，实施例1～4、6、7、10和比较例1～3的样品还是确认到粘合剂层的内聚力弱、剥离样品时容易产生残胶的倾向。可以认为：添加丙烯酸(AA)作为共聚单体并使其共聚时，粘合剂层的内聚力变弱的原因在于，由于流延用溶液中以高浓度包含的单油酸山梨糖醇酐酯，交联剂与丙烯酸(AA)的交联反应受到抑制，粘合性高分子化合物的交联变得不充分。Therefore, as shown in Table 5, in the samples prepared as Examples 1 to 4, 6, 7, 10 and Comparative Examples 1 to 3, acrylic acid (AA) was added as a comonomer and copolymerized, and further added with isocyanate The pressure-sensitive adhesive layer was prepared in such a composition that the weight ratio of the solid content of the crosslinking agent to the pressure-sensitive adhesive layer was 2.0% by weight or more. Nevertheless, in the samples of Examples 1 to 4, 6, 7, and 10 and Comparative Examples 1 to 3, it was confirmed that the cohesive force of the adhesive layer was weak, and tended to easily generate adhesive residue when the samples were peeled off. It is considered that when acrylic acid (AA) is added as a comonomer and copolymerized, the cohesive force of the adhesive layer becomes weak because the sorbitan monooleate contained in a high concentration in the casting solution, The crosslinking reaction between the crosslinking agent and acrylic acid (AA) is suppressed, and the crosslinking of the adhesive polymer compound becomes insufficient.
另一方面，作为成为交联点的共聚单体而添加羟基乙基丙烯酰胺(HEAA)并使其共聚时、添加丙烯酸羟基乙酯(HEA)并使其共聚时，即使异氰酸酯系交联剂的固体成分相对于粘合剂层所占的重量比少至0.8重量％，粘合剂层的粘合特性仍然良好。On the other hand, when hydroxyethylacrylamide (HEAA) is added and copolymerized as a comonomer serving as a crosslinking point, or when hydroxyethyl acrylate (HEA) is added and copolymerized, even the isocyanate-based crosslinking agent Even when the weight ratio of the solid content to the adhesive layer is as low as 0.8% by weight, the adhesive property of the adhesive layer is still good.
基于研究的结果，添加羟基乙基丙烯酰胺(HEAA)并使其共聚时、添加丙烯酸羟基乙酯(HEA)并使其共聚时，以异氰酸酯系交联剂的固体成分所占的重量比达到0.8重量％的组成制备实施例5、9。可以认为：添加羟基乙基丙烯酰胺(HEAA)或丙烯酸羟基乙酯(HEA)并使其共聚时，与添加丙烯酸(AA)并使其共聚的情况相比，交联反应不易受到单油酸山梨糖醇酐酯的抑制，即使异氰酸酯系交联剂的添加量少，粘合性高分子化合物的交联反应也会充分进行。Based on research results, when hydroxyethylacrylamide (HEAA) is added and copolymerized, and when hydroxyethyl acrylate (HEA) is added and copolymerized, the weight ratio of the solid content of the isocyanate-based crosslinking agent reaches 0.8 Compositions in % by weight Examples 5, 9 were prepared. It is considered that when hydroxyethylacrylamide (HEAA) or hydroxyethyl acrylate (HEA) is added and copolymerized, the cross-linking reaction is less susceptible to crosslinking than when acrylic acid (AA) is added and copolymerized. Inhibition of anhydrous sugar-alcohol ester allows the cross-linking reaction of the adhesive polymer compound to proceed sufficiently even if the amount of the isocyanate-based cross-linking agent added is small.
另一方面，作为成为交联点的共聚单体，添加羟基乙基丙烯酰胺(HEAA)并使其共聚，进而添加作为交联剂的用封端剂进行了保护(封端化)的异氰酸酯系交联剂时，为了使粘合剂层的粘合特性变得良好，需要以被封端剂保护的异氰酸酯系交联剂的固体成分相对于粘合剂层所占的重量比达到1.1重量％的方式进行添加。On the other hand, hydroxyethylacrylamide (HEAA) is added and copolymerized as a comonomer serving as a crosslinking point, and an isocyanate-based compound protected (blocked) with a blocking agent is added as a crosslinking agent. In the case of a cross-linking agent, in order to improve the adhesive properties of the adhesive layer, the solid content of the isocyanate-based cross-linking agent protected by the blocking agent must be 1.1% by weight relative to the weight of the adhesive layer. way to add.
基于研究的结果，添加羟基乙基丙烯酰胺(HEAA)并使其共聚、进而添加用封端剂保护的异氰酸酯系交联剂时，以交联剂的固体成分所占的重量比达到1.1重量％的组成制备实施例8。可以认为：添加用封端剂保护的异氰酸酯系交联剂时，与未用封端剂保护的情况相比，需要大量添加交联剂，但不能说交联反应受到抑制。可以认为：异氰酸酯系交联剂的分子中参与交联反应的是异氰酸酯基，但交联剂的分子键合有封端剂的分子，因此，异氰酸酯基在交联剂的分子中所占的比率降低，包括封端剂的重量部分在内需要大量添加交联剂。可以认为：添加用封端剂保护的异氰酸酯系交联剂时，各个异氰酸酯基与实施例9的情况同样地进行交联反应。Based on research results, when hydroxyethylacrylamide (HEAA) is added and copolymerized, and an isocyanate-based crosslinking agent protected with a blocking agent is added, the weight ratio of the solid content of the crosslinking agent becomes 1.1% by weight The composition of Preparation Example 8. It is considered that when an isocyanate-based crosslinking agent blocked with a blocking agent is added, it is necessary to add a larger amount of the crosslinking agent than when not blocked with a blocking agent, but it cannot be said that the crosslinking reaction is suppressed. It can be considered that the isocyanate group is involved in the cross-linking reaction in the molecule of the isocyanate-based cross-linking agent, but the molecules of the cross-linking agent are bonded to the molecules of the blocking agent. Therefore, the ratio of the isocyanate group to the molecule of the cross-linking agent Reduced, including the weight part of the end-capping agent, a large amount of cross-linking agent needs to be added. It is considered that when an isocyanate-based crosslinking agent blocked with a blocking agent is added, each isocyanate group undergoes a crosslinking reaction in the same manner as in Example 9.
[上妆性好坏的评价方法][How to evaluate the quality of makeup application]
针对实施例和比较例的样品，利用如下方法评价上妆性的好坏。Regarding the samples of Examples and Comparative Examples, the quality of makeup application was evaluated by the following method.
(1)作为化妆品，准备了粉末的平均粒径d为6μm的市售粉底。另外，20～35岁的5名女性作为受试者参加。(1) As cosmetics, a commercially available foundation having a powder average particle size d of 6 μm was prepared. In addition, 5 females aged 20 to 35 participated as test subjects.
(2)受试者将皮肤遮蔽材料的样品粘贴于脸颊，进而在其上利用通常的使用方法涂布市售的粉底，并化妆。(2) The test subject sticks the sample of the skin masking material on the cheek, and then applies a commercially available foundation on the cheek by a usual method of use, and puts on make-up.
(3)受试者观察已上妆的自己的脸颊，按照如下基准对观察结果进行评分。(3) The subjects observed their own cheeks with makeup on, and rated the observation results according to the following criteria.
与未粘贴样品的情况相比，感觉上妆性不变的情况···10分When compared with the case where the sample is not pasted, the feeling of makeup application remains the same... 10 points
与未粘贴样品的情况相比，感觉上妆性存在不协调感的情况···7分Compared with the case where the sample is not pasted, the case where the make-up is felt to be incongruous... 7 points
与未粘贴样品的情况相比，感觉上妆性略差的情况···4分The case where makeup application is slightly inferior compared to the case where the sample is not pasted... 4 points
与未粘贴样品的情况相比，感觉上妆性明显差的情况···0分When compared with the case where the sample is not pasted, the case where makeup application is remarkably inferior... 0 points
(4)根据5名受试者的评分结果求出平均分，按照如下基准进行评价。(4) The average score was calculated|required from the scoring result of 5 test subjects, and evaluation was performed according to the following reference|standard.
8.0分～10.0分···◎8.0 to 10.0 points...◎
6.0分～低于8.0分···○6.0 points to less than 8.0 points...○
4.0分～低于6.0分···△4.0 points to less than 6.0 points...△
低于4.0分···×Below 4.0 points···×
[上妆性好坏的评价结果和研究][Evaluation results and research on the quality of makeup application]
针对实施例和比较例的样品，将上妆性好坏的评价结果示于表6。Table 6 shows the evaluation results of makeup application properties for the samples of Examples and Comparative Examples.
[表6][Table 6]
如表6所示那样，在实施例和比较例中，基于薄膜层的另一面的Rz值，上妆性的好坏产生差异。实施例3和6～10的Rz为18μm或25μm，与受试者未粘贴样品的情况相比，感觉上妆性不变。实施例1、4和5中的Rz为10μm，与受试者未粘贴样品的情况相比，感觉上妆性有不协调感。实施例2中的Rz为6μm，与受试者未粘贴样品的情况相比，感觉上妆性略差。比较例1～3中的Rz为0.9～5μm，与受试者未粘贴样品的情况相比，感觉上妆性明显差。As shown in Table 6, in Examples and Comparative Examples, the quality of makeup application differs depending on the Rz value on the other side of the film layer. In Examples 3 and 6 to 10, Rz was 18 μm or 25 μm, and compared with the case where the test subject did not apply the sample, the cosmetic application was not changed. In Examples 1, 4, and 5, Rz was 10 μm, and compared with the case where the test subject did not stick the sample, the makeup application was felt to be incongruous. Rz in Example 2 was 6 μm, and compared with the case where the test subject did not stick the sample, it felt that makeup application was slightly inferior. Rz in Comparative Examples 1 to 3 was 0.9 to 5 μm, and compared with the case where the test subject did not stick the sample, the makeup feeling was significantly inferior.
这些评价结果可以通过Rz相对于平均粒径d的比率的值来换个说法。换言之，Rz相对于化妆品中包含的粉末的平均粒径d的比值为3.0倍或4.2倍时，与未化妆的皮肤相比，感觉上妆性不变。该比值为1.7倍时，与未化妆的皮肤相比，感觉上妆性有不协调感。该比值为1.0倍时，与未化妆的皮肤相比，感觉上妆性略差。该比值为0.2倍～0.8倍时，与未化妆的皮肤相比，感觉上妆性明显差。根据这些评价结果可知，本发明的皮肤遮蔽材料为了发挥出上妆性良好的效果，另一面的Rz为化妆品中包含的粉末的平均粒径d的1.0倍以上是必须的。These evaluation results can be expressed differently by the value of the ratio of Rz to the average particle diameter d. In other words, when the ratio of Rz to the average particle diameter d of the powder contained in the cosmetic is 3.0 times or 4.2 times, the makeup feeling does not change compared with the skin without makeup. When the ratio is 1.7 times, compared with the skin without make-up, the make-up property feels unbalanced. When the ratio is 1.0 times, compared with the skin without make-up, the make-up feeling is slightly inferior. When the ratio is 0.2 to 0.8 times, makeup application is remarkably inferior to skin without makeup. From these evaluation results, it can be seen that in order for the skin masking material of the present invention to exert a good makeup application effect, Rz on the other side must be 1.0 times or more the average particle diameter d of the powder contained in the cosmetic.
另外，认为比较例3中，薄膜层的聚乙烯(PE)树脂与化妆品中包含的粉末的亲和性低、形成于另一面的凹部带有弧度、粉末容易滑落也是比较例3中受试者感觉上妆性明显差的原因。认为如聚醚聚氨酯(EU)树脂、聚酯聚氨酯树脂那样，薄膜层的树脂与化妆品中包含的粉末的亲和性高时，会进一步发挥出上妆性良好的效果。In addition, in Comparative Example 3, it is considered that the polyethylene (PE) resin of the film layer has a low affinity with the powder contained in the cosmetics, and the concave portion formed on the other side is curved, and the powder is easy to slip off. The reason for the obvious poor makeup. It is considered that when the affinity between the resin of the film layer and the powder contained in cosmetics is high, such as polyether urethane (EU) resin and polyester urethane resin, the effect of better makeup application is further exhibited.
需要说明的是，实施例1～10、比较例1、2中，薄膜层的树脂为聚醚聚氨酯(EU)树脂，成为薄膜层原材料的薄膜的拉伸弹性模量在0.2～5MPa的范围内，粘贴样品后，受试者的脸颊触感没有不协调感。另一方面，比较例3中，薄膜层的树脂为聚乙烯(PE)树脂，成为薄膜层原材料的薄膜的拉伸弹性模量超过5MPa，粘贴样品后，受试者感到脸颊紧绷，具有不协调感。因此，比较例3中，受试者在涂布化妆品后无意识地用手指触碰样品时妆容剥落的痕迹明显。根据上述情况也可知：在另一面保持粉末的基础上，成为薄膜层原材料的薄膜的拉伸弹性模量优选在0.2～5MPa的范围内。It should be noted that, in Examples 1 to 10 and Comparative Examples 1 and 2, the resin of the film layer is polyether polyurethane (EU) resin, and the tensile modulus of the film that becomes the raw material of the film layer is in the range of 0.2 to 5 MPa , After the sample was pasted, the subject's cheeks had no sense of incongruity. On the other hand, in Comparative Example 3, the resin of the film layer was polyethylene (PE) resin, and the tensile modulus of the film used as the raw material of the film layer exceeded 5 MPa. coordination. Therefore, in Comparative Example 3, when the test subject touched the sample with a finger unintentionally after applying the cosmetic, traces of makeup peeling were noticeable. From the above, it can also be seen that the tensile modulus of the film used as the raw material of the film layer is preferably in the range of 0.2 to 5 MPa after the powder is held on the other side.
[遮蔽性的评价方法][evaluation method of concealment properties]
针对实施例和比较例的样品，利用如下方法评价遮蔽性。Regarding the samples of Examples and Comparative Examples, the masking property was evaluated by the following method.
(1)受试者在脸颊上施加直径3mm的假黑痣，进而在其上粘贴样品。(1) The test subject applied a fake mole with a diameter of 3 mm on the cheek, and then pasted the sample on it.
(2)受试者观察未化妆的自己的脸颊，按照如下基准对观察结果进行评价。(2) The subjects observed their own cheeks without makeup, and evaluated the observation results according to the following criteria.
基本看不到假黑痣的情况···○Fake moles are almost invisible...○
隐隐约约知道存在假黑痣的情况···△I vaguely know that there are fake moles...△
明显可知存在假黑痣的情况···×It is obvious that there are false moles...×
[遮蔽性的评价结果和研究][Evaluation results and research on concealment properties]
针对实施例和比较例的样品，将遮蔽性的评价结果示于表7。Table 7 shows the evaluation results of masking properties for the samples of Examples and Comparative Examples.
[表7][Table 7]
如表7所示那样，实施例1～10、比较例1～3中，基于薄膜层的总光线透射率的差异，遮蔽性的评价结果产生差异。实施例1～10中，薄膜层的总光线透射率为85.4～89.8％，显示出基本看不到假黑痣的良好遮蔽性。另一方面，比较例1和3中，总光线透射率为90.6～91.1％，显示出隐隐约约知道存在假黑痣的程度的遮蔽性。比较例2中，总光线透射率为95.9％，明显可知存在假黑痣，基本未显示出遮蔽性。As shown in Table 7, in Examples 1-10 and Comparative Examples 1-3, the evaluation result of shielding property differed based on the difference in the total light transmittance of a thin film layer. In Examples 1 to 10, the total light transmittance of the thin film layer was 85.4 to 89.8%, showing a good shielding property in which false moles were hardly seen. On the other hand, in Comparative Examples 1 and 3, the total light transmittance was 90.6 to 91.1%, and the masking property was shown to the extent that the presence of false moles was vaguely recognized. In Comparative Example 2, the total light transmittance was 95.9%, and it was evident that there were false moles, and there was basically no concealment.
由这些遮蔽性的评价结果示出：薄膜层的总光线透射率越低则遮蔽性越高、总光线透射率约为90％以下则皮肤遮蔽材料具有良好的遮蔽性。另外，可以认为：实施例1～10、比较例1和3中，薄膜层的平行光线透射率为9.3～10.6％，且薄膜层的雾度(雾值)为87.8～89.4％有助于遮蔽性的发挥。另一方面，可以认为：比较例2中，薄膜层的平行光线透射率为60.8％、且薄膜层的雾度(雾值)为36.6％与不显示遮蔽性的结果有关。需要说明的是，实施例和比较例的样品中，粘合剂层透明且厚度薄至15μm，因此，认为基本不影响遮蔽性的评价结果。The evaluation results of these shielding properties show that the lower the total light transmittance of the film layer, the higher the shielding property, and the skin masking material has good shielding properties if the total light transmittance is about 90% or less. In addition, it can be considered that in Examples 1 to 10 and Comparative Examples 1 and 3, the parallel light transmittance of the thin film layer is 9.3 to 10.6%, and the haze (haze value) of the thin film layer is 87.8 to 89.4%, which contributes to shielding. Sexual play. On the other hand, in Comparative Example 2, the parallel light transmittance of the thin film layer was 60.8%, and the haze (haze value) of the thin film layer was 36.6%, which was considered to be related to the result of not showing shielding properties. In addition, in the samples of the Example and the comparative example, since the pressure-sensitive adhesive layer was transparent and the thickness was as thin as 15 μm, it is considered that it did not substantially affect the evaluation result of the masking property.
关于薄膜层的材质，存在比较例1的树脂为聚醚聚氨酯(EU)、比较例3的树脂为聚乙烯(PE)的不同。但是，比较例1中的薄膜层的总光线透射率为91.1％，而比较例3中的薄膜层的总光线透射率为90.6％，因此，两者的总光线透射率的值近似，遮蔽性的评价基本相同。可以认为：即使薄膜层的树脂不同，若总光线透射率近似，则皮肤遮蔽材料显示基本相同的遮蔽性。Regarding the material of the film layer, the resin of Comparative Example 1 is polyether polyurethane (EU), and the resin of Comparative Example 3 is polyethylene (PE). However, the total light transmittance of the thin film layer in Comparative Example 1 is 91.1%, while the total light transmittance of the thin film layer in Comparative Example 3 is 90.6%. Therefore, the values of the total light transmittance of the two are similar, and the shielding properties are similar. evaluations are basically the same. It is considered that even if the resins of the film layers are different, if the total light transmittances are similar, the skin masking materials will exhibit substantially the same masking properties.
因此，可以认为：皮肤遮蔽材料的遮蔽性直接取决于薄膜层的总光线透射率。另外，出于上述原因，可以认为：薄膜层的总光线透射率取决于分散在薄膜层的微粒和另一面的Rz。因此，可以认为：薄膜层中分散有微粒和另一面的Rz为6μm以上对于降低皮肤遮蔽材料的总光线透射率而发挥遮蔽性而言是有效的。Therefore, it can be considered that the shielding property of the skin shielding material directly depends on the total light transmittance of the film layer. In addition, for the above reasons, it can be considered that the total light transmittance of the thin film layer depends on the particles dispersed in the thin film layer and Rz on the other side. Therefore, it is considered that particles dispersed in the film layer and an Rz of 6 μm or more on the other side are effective in reducing the total light transmittance of the skin shielding material and exerting shielding properties.
[抗菌性的评价方法][Evaluation method of antibacterial properties]
针对实施例和比较例的样品，通过如下方法评价抗菌性。The antibacterial property was evaluated by the following method about the samples of the Example and the comparative example.
(1)作为琼脂培养基，使用了日水制药株式会社制造的Mueller-Hinton琼脂培养基-N。将琼脂培养基用高压釜在121℃、15分钟的条件下加热杀菌。(1) As an agar medium, Mueller-Hinton agar medium-N manufactured by Niksui Pharmaceutical Co., Ltd. was used. The agar medium was heat-sterilized in an autoclave at 121° C. for 15 minutes.
(2)琼脂培养基冷却一定程度后，将琼脂培养基分注至培养皿内。向该琼脂培养基中接种金黄色葡萄球菌，所述金黄色葡萄球菌是以浓度达到约106cfu/ml的方式制备的。(2) After the agar medium is cooled to a certain extent, dispense the agar medium into the petri dish. Into this agar medium was inoculated Staphylococcus aureus prepared in such a manner that the concentration was about 106 cfu/ml.
(3)将样品切成直径10mm后，从样品剥掉粘合剂保护部而使粘合剂层的皮肤接触面露出。将剥掉粘合剂保护部后的样品以皮肤接触面朝向下侧，载置于固化后的含指示菌株的琼脂培养基的中央。(3) After the sample was cut to 10 mm in diameter, the adhesive protection part was peeled off from the sample to expose the skin contact surface of the adhesive layer. The sample after peeling off the adhesive protection part was placed in the center of the cured agar medium containing the indicator strain with the skin contact surface facing down.
(4)将该培养基在37℃的气氛中静置48小时，从而培养指示菌株。(4) The culture medium was left to stand in an atmosphere of 37° C. for 48 hours to culture the indicator strain.
(5)经过48小时后，测定出现在培养基表面的抑菌圈的直径。此时按照如下基准评价样品的抗菌性。(5) After 48 hours, the diameter of the zone of inhibition appearing on the surface of the culture medium was measured. At this time, the antibacterial properties of the samples were evaluated according to the following criteria.
确认不到抑菌圈···×No zone of inhibition can be confirmed...×
确认到抑菌圈，直径不足15mm···○The zone of inhibition was confirmed and the diameter was less than 15mm...○
确认到抑菌圈，直径为15mm以上···◎The zone of inhibition was confirmed, with a diameter of 15mm or more...◎
[抗菌性的评价结果和研究][Evaluation results and studies of antibacterial properties]
针对实施例和比较例的样品，将抗菌性的评价结果示于表8。Table 8 shows the evaluation results of antibacterial properties for the samples of Examples and Comparative Examples.
[表8][Table 8]
如表8所示那样，实施例1～10、比较例1～3中，基于粘合剂层中包含的针对皮肤的药效成分，抗菌性的评价结果产生差异。实施例7～10中，药效成分为抗菌剂异丙基甲基苯酚，显示出可确认到直径15mm以上的抑菌圈的良好抗菌性。实施例4～6中，药效成分为水杨酸或α-羟基酸类的乳酸，确认到直径不足15mm的抑菌圈，显示出具有抗菌性。实施例1～3、比较例1～3中，粘合剂层不含针对皮肤的药效成分，未确认到抑菌圈，因此，未显示抗菌性。As shown in Table 8, in Examples 1 to 10 and Comparative Examples 1 to 3, there was a difference in the evaluation results of antibacterial properties based on the medicinal ingredients for the skin contained in the adhesive layer. In Examples 7 to 10, the medically effective ingredient was the antibacterial agent isopropylmethylphenol, and showed good antibacterial properties in which a zone of inhibition with a diameter of 15 mm or more was confirmed. In Examples 4 to 6, the active ingredient was salicylic acid or lactic acid of α-hydroxy acids, and an inhibition zone with a diameter of less than 15 mm was confirmed, showing antibacterial properties. In Examples 1 to 3 and Comparative Examples 1 to 3, the adhesive layer did not contain a medicinal ingredient for the skin, and no zone of inhibition was confirmed, and thus did not exhibit antibacterial properties.
根据这些评价结果可以明确：粘合剂层包含针对皮肤的药效成分时，药效成分从粘合剂层中释放而显示出抗菌性。可以认为：本发明的皮肤遮蔽材料不仅可用作医药品，还可以在医药外用品、化妆品的领域中活用。From these evaluation results, it is clear that when the adhesive layer contains a medicinal ingredient for the skin, the medicinal ingredient is released from the adhesive layer to exhibit antibacterial properties. It is considered that the skin masking material of the present invention can be utilized not only as medicines but also in the fields of quasi-drugs and cosmetics.
[基于受试者的痛感的评价方法][Evaluation method based on subject's pain perception]
针对实施例8～10的样品，通过如下方法评价痛感。About the samples of Examples 8-10, the pain sensation was evaluated by the following method.
(1)将样品贴附于受试者的前臂内侧部的皮肤。(1) The sample is attached to the skin of the test subject's inner forearm.
(2)经过6小时后，从受试者的皮肤剥掉样品。(2) After 6 hours have elapsed, the sample is peeled off from the test subject's skin.
(3)用针尖扎刺剥掉样品后的部位的皮肤来施加刺激。每次扎刺时，对针尖施加相同的力。(3) The skin of the site where the sample was peeled off was pricked with a needle point to give stimulation. Apply the same amount of force to the needle tip each time you pierce.
(4)按照如下基准，针对被针尖扎刺时受试者的感觉进行评价。(4) The test subject's feeling when being pricked by the needle tip was evaluated according to the following criteria.
受试者完全没有任何感觉的情况···◎The case where the subject feels absolutely nothing...◎
受试者略微有点感觉的情况···○The case where the subject feels a little... ○
受试者略微感到可认为是疼痛的触感的情况···△When the subject feels a slight tactile sensation that can be considered painful...△
受试者感到疼痛的情况···×Subjects feel pain···×
受试者强烈感到疼痛的情况···××The case where the subject felt intense pain...××
[基于受试者的痛感的评价结果和研究][Evaluation results and research based on subjects' pain perception]
针对实施例8～10的样品，将基于受试者的痛感的评价结果示于表9。Table 9 shows the evaluation results based on the pain sensation of the test subjects for the samples of Examples 8 to 10.
[表9][Table 9]
如表9所示那样，实施例8～10的粘合剂层中包含的抗炎药为皮考布洛芬。另一方面，实施例8～10中，成为粘合剂层的粘合性高分子的主要成分的单体不同，基于受试者的痛感评价产生差异。As shown in Table 9, the anti-inflammatory drug contained in the pressure-sensitive adhesive layers of Examples 8 to 10 was picoibuprofen. On the other hand, in Examples 8 to 10, the monomer used as the main component of the adhesive polymer of the adhesive layer was different, and a difference occurred based on the pain evaluation of the test subjects.
实施例8和实施例9的交联剂不同，但主要成分是使丙烯酸2-乙基己酯(2-EHA)、醋酸乙烯酯(VA)、丙烯酸羟基乙酯(HEA)共聚而得到的粘合性高分子这一点是相同的。实施例8、9中，受试者被针尖扎刺时，痛感被抑制到略微感到某种触感的程度。另一方面，实施例10中，主要成分是使丙烯酸2-乙基己酯(2-EHA)、丙烯酸甲氧基乙酯(MEA)、丙烯酸(AA)共聚而得到的粘合性高分子化合物，受试者被针尖扎刺时，痛感被抑制到略微感到可认为是疼痛的触感的程度。The crosslinking agent of embodiment 8 and embodiment 9 is different, but main component is the adhesive obtained by copolymerizing 2-ethylhexyl acrylate (2-EHA), vinyl acetate (VA), hydroxyethyl acrylate (HEA). Synthetic polymers are the same. In Examples 8 and 9, when the subject was pricked by the needle tip, the pain was suppressed to such an extent that a certain tactile sensation was slightly felt. On the other hand, in Example 10, the main component is an adhesive polymer compound obtained by copolymerizing 2-ethylhexyl acrylate (2-EHA), methoxyethyl acrylate (MEA), and acrylic acid (AA). , when the subject was pricked by the needle tip, the pain was suppressed to the point where a slight tactile sensation could be considered as pain.
由这些评价结果示出：粘合剂层包含抗炎药皮考布洛芬时，皮考布洛芬被释放至皮肤。可以认为：皮肤遮蔽材料可以在医药品的领域中活用。另外，即使交联剂不同，皮考布洛芬自粘合剂层的释放也不存在差异。These evaluation results show that when the adhesive layer contains the anti-inflammatory drug picobuprofen, picobuprofen is released to the skin. It is considered that the skin masking material can be utilized in the field of pharmaceuticals. In addition, even if the crosslinking agent is different, there is no difference in the release of picobuprofen from the adhesive layer.
另一方面，由这些评价结果示出：基于构成粘合剂层的粘合性高分子化合物的单体的不同，皮考布洛芬的释放程度不同。可以认为：实施例10中，由于粘合性高分子化合物具有源自丙烯酸(AA)的羧基，皮考布洛芬具有吡啶环，因此，通过这些极性基团的相互作用，皮考布洛芬在粘合剂层中稳定化，释放速度降低。可以认为：本发明的皮肤遮蔽材料使用具有极性基团的粘合性高分子化合物作为粘合剂层的原材料时，对皮考布洛芬等具有极性基团的有机化合物发挥出缓释性。On the other hand, these evaluation results show that the degree of picobuprofen release varies depending on the monomer of the adhesive polymer compound constituting the adhesive layer. It is considered that in Example 10, since the adhesive polymer compound has a carboxyl group derived from acrylic acid (AA), picobuprofen has a pyridine ring, and therefore, through the interaction of these polar groups, picobuprofen Fen is stabilized in the adhesive layer and the release rate is reduced. It is considered that when the skin masking material of the present invention uses an adhesive polymer compound having a polar group as a raw material of the adhesive layer, it exhibits a sustained-release effect on organic compounds having a polar group such as picobuprofen. sex.
[基于动物实验的痛感的评价方法][Evaluation method of pain perception based on animal experiments]
针对实施例8～10的样品，通过如下方法来评价痛感。About the samples of Examples 8-10, the pain sensation was evaluated by the following method.
(1)从Charles River Laboratories International,Inc.购买6周龄的经SPF化的Wistar/ST系雄性大鼠，并进行预饲养。(1) 6-week-old SPF-treated Wistar/ST male rats were purchased from Charles River Laboratories International, Inc. and pre-raised.
(2)剃掉大鼠背部的毛后，将实施例1、7、比较例1的样品分别贴附于背部。使用医疗用粘合绷带，将贴附的样品整体与灭菌纱布一同覆盖并固定。(2) After the hair on the back of the rat was shaved, the samples of Examples 1, 7, and Comparative Example 1 were respectively attached to the back. Use a medical adhesive bandage to cover and fix the entire attached sample together with sterilized gauze.
(3)经过6小时后，从背部剥掉样品。(3) After 6 hours passed, the sample was peeled off from the back.
(4)用针尖扎刺背部之中的剥掉样品后的部位来施加刺激。每次扎刺时，对针尖施加相同的力。同样地，用针尖扎刺背部之中的未贴附样品的部位来施加刺激。(4) Stimulation is given by pricking the part of the back where the sample has been peeled off with a needle point. Apply the same amount of force to the needle tip each time you pierce. Similarly, stimulation was applied by pricking a part of the back where the sample was not attached with a needle tip.
(5)按照如下基准来评价用针尖扎刺时大鼠表现出的反应。(5) The reaction exhibited by the rat when pricked with a needle tip was evaluated according to the following criteria.
大鼠未表现出任何反应的情况···○The case where the rat did not show any response... ○
大鼠刚被扎刺后表现出某种体动反应的情况···△Rats showing some kind of body movement response just after being pricked... △
大鼠表现出躲避针尖的行动的情况···×Cases in which rats exhibit behavior to avoid the needle tip···×
[基于动物实验的痛感的评价结果和研究][Evaluation results and studies of pain perception based on animal experiments]
针对实施例8～10的样品，将基于动物实验的痛感的评价结果示于表10。Table 10 shows the evaluation results of pain sensation based on animal experiments for the samples of Examples 8 to 10.
[表10][Table 10]
如表10所示那样，基于动物实验的痛感评价与表9所示的基于受试者的痛感评价呈现相同的结果。另外，动物实验中，用针尖扎刺背部之中的未贴附样品的部位来施加刺激时，大鼠呈现躲避行动，可确认到用针尖扎刺时对皮肤造成了刺激。基于受试者和动物实验的痛感评价试验表明：贴附有实施例8～10的样品时，从皮肤遮蔽材料释放出皮考布洛芬，痛感得以缓和。As shown in Table 10, the pain evaluation based on the animal experiment and the pain evaluation based on the test subjects shown in Table 9 showed the same results. In addition, in animal experiments, when stimulation was applied by pricking a part of the back where the sample was not attached with a needle point, the rats showed avoidance behavior, and it was confirmed that the skin was irritated when the needle point was pricked. Pain evaluation tests based on human subjects and animal experiments showed that when the samples of Examples 8 to 10 were attached, picobuprofen was released from the skin masking material, and the pain was alleviated.
[创伤治愈的评价方法][Evaluation method of wound healing]
针对实施例1、5、比较例3的样品，通过如下方法来评价创伤治愈。Regarding the samples of Examples 1, 5, and Comparative Example 3, wound healing was evaluated by the following method.
(1)从Charles River Laboratories International,Inc.购买6周龄的经SPF化的Wistar/ST系雄性大鼠，每组各6只并进行预饲养。(1) Purchase 6-week-old SPFized Wistar/ST male rats from Charles River Laboratories International, Inc., 6 in each group and perform pre-feeding.
(2)剃掉大鼠背部的毛，在醚麻醉下制作直径为10mm的全缺损创伤。(2) The hair on the back of the rat was shaved, and a total defect wound with a diameter of 10 mm was made under ether anesthesia.
(3)在伤部贴附样品，在样品上载置纱布，使用医疗用粘合绷带从纱布上固定已贴附的样品整体。为了预防感染，作为抗生素，肌内给药结晶青霉素G(Meiji Seika PharmaCo.,Ltd.制)。(3) Attach the sample to the wound, place gauze on the sample, and fix the entire attached sample from the gauze using a medical adhesive bandage. To prevent infection, as an antibiotic, crystalline penicillin G (manufactured by Meiji Seika Pharma Co., Ltd.) was intramuscularly administered.
(4)将致伤日记作0天，以后每隔一日更换样品。进行更换时，观察创伤的状态。(4) Set the injury diary as 0 day, and replace the sample every other day thereafter. When performing replacement, observe the state of the wound.
(5)基于创伤的观察结果，每组6只之中的5只以上符合如下基准时，评价创伤治愈。(5) Based on the wound observation results, when 5 or more of the 6 animals in each group met the following criteria, the wound healing was evaluated.
基本观察不到浸出液的泄漏，在8天以内观察到创伤的闭合···◎Leakage of the leachate was basically not observed, and the closure of the wound was observed within 8 days...◎
基本观察不到浸出液的泄漏，在10天以内观察到创伤的闭合···○Leakage of the leachate was basically not observed, and the closure of the wound was observed within 10 days... ○
观察到浸出液的泄漏，在10天以内观察到创伤的闭合···△Leakage of leachate was observed, closure of wound was observed within 10 days···△
观察到浸出液的泄漏，在10天以内观察不到创伤的闭合···×Leakage of leachate was observed, no closure of the wound was observed within 10 days···×
[创伤治愈的评价结果和研究][Evaluation Results and Research on Wound Healing]
针对实施例8～10的样品，将创伤治愈的评价结果示于表11。Table 11 shows the evaluation results of wound healing for the samples of Examples 8 to 10.
[表11][Table 11]
如表11所示那样，比较例3中，薄膜层的树脂为聚乙烯(PE)，与此相对，实施例1和5中，薄膜层的树脂为聚醚聚氨酯(EU)。由于薄膜层的树脂不同，因此透湿度不同，相对于比较例3，实施例1和5中的创伤治愈的评价结果产生差异。实施例1和5中，透湿度在900～5,000g/(m2·天)的范围内，基本观察不到浸出液的泄漏，因此，剥掉样品时的异味较小，在8天时观察到创伤的闭合。与此相对，比较例3中，透湿度为30g/(m2·天)，观察到浸出液大量泄漏，因此，剥掉样品时的异味较大，至观察到创伤闭合为止耗费了10天。As shown in Table 11, in Comparative Example 3, the resin of the film layer was polyethylene (PE), whereas in Examples 1 and 5, the resin of the film layer was polyether polyurethane (EU). Since the resin of the film layer is different, the water vapor transmission rate is different, and the evaluation results of wound healing in Examples 1 and 5 are different from those in Comparative Example 3. In Examples 1 and 5, the moisture permeability was in the range of 900 to 5,000 g/(m2 ·day), and the leakage of the leachate was hardly observed. Therefore, the peculiar smell when the sample was peeled off was small, and wounds were observed at 8 days of the closure. In contrast, in Comparative Example 3, the moisture permeability was 30 g/(m2 ·day), and a large amount of leakage of the leachate was observed. Therefore, the odor was strong when the sample was peeled off, and it took 10 days until wound closure was observed.
由这些评价结果示出：透湿度高时，创伤治愈变得良好。可以认为：作为薄膜层的原材料而使用透湿度高的薄膜时，贴附有皮肤遮蔽材料的创面闷热受到抑制，创面周围的皮肤处的皮肤常驻菌的增殖受到抑制，促进迅速形成完好的表皮，创伤治愈变得良好。反之，可以认为：使用透湿度低的薄膜时，贴附有皮肤遮蔽材料的创面周围的皮肤闷热，细菌从周围的皮肤转移至创面，细菌在创面处增殖而对创伤治愈造成不良影响。使用了低透湿度薄膜的样品在剥离时的强烈异味是因为创面周围的皮肤的水分增加而呈现湿润状态、皮肤常驻菌增殖而产生的。These evaluation results show that wound healing becomes good when the water vapor transmission rate is high. It can be considered that when a film with high moisture permeability is used as the raw material of the film layer, the wound surface to which the skin masking material is attached will be suppressed from being stuffy, the proliferation of skin resident bacteria in the skin around the wound surface will be suppressed, and the rapid formation of a good epidermis will be promoted. , wound healing becomes good. Conversely, it can be considered that when a film with low moisture permeability is used, the skin around the wound surface to which the skin masking material is attached will be sultry, bacteria will transfer from the surrounding skin to the wound surface, and bacteria will proliferate in the wound surface, thereby adversely affecting wound healing. The strong odor when peeling off the sample using the low moisture permeability film is due to the increase in the moisture content of the skin around the wound, resulting in a wet state and the proliferation of skin resident bacteria.
需要说明的是，在进行创伤治愈的评价试验时，实施例1、5、比较例3中，任意样品均没有结痂地治愈，形成了完好的表皮。即使在粘合剂层中不含针对皮肤的药效成分的实施例1和比较例3中也确认到该创伤治愈的效果，因此，该效果并非起因于药效成分。该效果是由实施例1、5、比较例3中均通过构成样品的薄膜层与粘合剂层来覆盖创面并维持湿润状态而带来的。In addition, in the evaluation test of wound healing, in Examples 1, 5, and Comparative Example 3, none of the samples healed without scabs, and a good epidermis was formed. This wound healing effect was confirmed even in Example 1 and Comparative Example 3 in which the adhesive layer did not contain a medicinal ingredient for the skin, and therefore, this effect was not attributable to the medicinal ingredient. This effect is brought about by covering the wound surface and maintaining a moist state through the film layer and the adhesive layer constituting the samples in Examples 1, 5, and Comparative Example 3.
另外，实施例1、5、比较例3均未在创面周围的皮肤观察到斑疹。获得该效果的原因在于，在常温下为液体且具有极性基团的有机化合物相对于粘合剂层的重量比为30重量％左右，因此，粘合剂层为凝胶状。粘合剂层为凝胶状时，在更换粘贴样品时，对皮肤的刺激受到抑制，能够抑制皮肤产生斑疹。本发明的皮肤遮蔽材料中的粘合剂层为凝胶状时，能够避免创面周围的皮肤产生斑疹而导致创伤治愈变慢。In addition, in Examples 1, 5, and Comparative Example 3, no rash was observed on the skin around the wound. This effect is obtained because the weight ratio of the polar group-containing organic compound, which is liquid at room temperature, to the adhesive layer is about 30% by weight, so the adhesive layer is gel-like. When the adhesive layer is in a gel form, skin irritation is suppressed when the pasted sample is replaced, and it is possible to suppress skin rashes. When the adhesive layer in the skin masking material of the present invention is in the form of gel, it can prevent the skin around the wound from producing macules and slowing down the healing of the wound.
产业上的可利用性Industrial availability
本发明的皮肤遮蔽材料为了隐藏皮肤产生的异质部分而贴附于该部分的皮肤，进而在其上涂抹粉底、遮瑕膏之类的化妆品，从而能够使该异质部分不明显。进而，本发明的皮肤遮蔽材料中的粘合剂层包含针对皮肤的药效成分时，在贴附于异质部分并上妆而使其不明显的同时，能够治疗异质部分。另外，本发明的皮肤遮蔽材料根据其形状、其贴附方式的不同，贴附于面部的松弛皮肤时，可提拉松弛的皮肤而矫正皮肤的皱纹、松弛，此时对贴附的皮肤遮蔽材料上妆而使其不明显时，能够使面部看起来较年轻。除此之外，本发明的皮肤遮蔽材料能够贴附于皮肤之外的物体表面，能够消除该表面的光泽、或者抑制该表面的光反射、或者使该表面不易打滑。即使在所述表面包含曲面、球面的情况下，也能够贴附本发明的皮肤遮蔽材料。The skin masking material of the present invention is attached to the skin in order to hide the heterogeneity generated in the skin, and then cosmetics such as foundation and concealer are applied thereon, so that the heterogeneity can be made inconspicuous. Furthermore, when the adhesive layer in the skin masking material of the present invention contains a medicinal ingredient for the skin, it is possible to treat the heterogeneity while affixing it to the heterogeneity and applying make-up to make it inconspicuous. In addition, the skin masking material of the present invention depends on its shape and the way it is attached. When it is attached to the sagging skin of the face, it can lift the slack skin and correct the wrinkles and sagging of the skin. When the material is applied with makeup so that it is not obvious, it can make the face look younger. In addition, the skin masking material of the present invention can be attached to the surface of an object other than the skin, and can eliminate the gloss of the surface, or suppress light reflection on the surface, or make the surface less slippery. Even when the surface includes a curved surface or a spherical surface, the skin masking material of the present invention can be attached.
附图标记说明Explanation of reference signs
2 皮肤遮蔽材料2 skin masking material
4 薄膜层4 film layers
6 粘合剂层6 Adhesive layers
10 另一面10 the other side
12 一面12 sides
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014011870 | 2014-01-24 | ||
| JP2014-011870 | 2014-01-24 | ||
| PCT/JP2015/052090WO2015111748A1 (en) | 2014-01-24 | 2015-01-26 | Skin-masking material |
| Publication Number | Publication Date |
|---|---|
| CN106102513A CN106102513A (en) | 2016-11-09 |
| CN106102513Btrue CN106102513B (en) | 2017-11-14 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580015231.2AExpired - Fee RelatedCN106102513B (en) | 2014-01-24 | 2015-01-26 | skin masking material |
| Country | Link |
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| JP (1) | JP6147874B2 (en) |
| KR (1) | KR101811937B1 (en) |
| CN (1) | CN106102513B (en) |
| WO (1) | WO2015111748A1 (en) |
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|---|---|---|---|---|
| TWI708619B (en) | 2019-09-06 | 2020-11-01 | 奧倫國際有限公司 | Active particle temperature difference slow release structure |
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| JP2001278739A (en)* | 2000-01-27 | 2001-10-10 | Dainippon Printing Co Ltd | Cosmetic concealing seal and method for making up skin unevenness and dark color |
| JP2001299808A (en)* | 2000-04-19 | 2001-10-30 | Sekisui Chem Co Ltd | Medial tape base material |
| JP2007021068A (en)* | 2005-07-21 | 2007-02-01 | Nitto Denko Corp | Adhesive tape or sheet for skin application |
| CN101842075A (en)* | 2007-09-28 | 2010-09-22 | 株式会社嘉月国际 | Cosmetic auxiliary patch material and method of cosmetizing therewith |
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| TWI708619B (en) | 2019-09-06 | 2020-11-01 | 奧倫國際有限公司 | Active particle temperature difference slow release structure |
| Publication number | Publication date |
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| JP6147874B2 (en) | 2017-06-14 |
| CN106102513A (en) | 2016-11-09 |
| KR20160003267A (en) | 2016-01-08 |
| KR101811937B1 (en) | 2017-12-22 |
| JPWO2015111748A1 (en) | 2017-03-23 |
| WO2015111748A1 (en) | 2015-07-30 |
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| CN106102513B (en) | skin masking material | |
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| HK1238277B (en) | Adhesive patch | |
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| C10 | Entry into substantive examination | ||
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| TR01 | Transfer of patent right | Effective date of registration:20230407 Address after:Shiga Patentee after:TOYO CHEMICAL Co.,Ltd. Address before:Shiga Patentee before:Pioneer Medical Corp. | |
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| CF01 | Termination of patent right due to non-payment of annual fee | Granted publication date:20171114 |