Summary of the invention
The main object of the present invention is to provide a kind of deep nasal cavity administration device, it is intended to solution must not be to nasal cavityThe problem that deep carries out the painless administration of noinvasive accurately.
For achieving the above object, the deep nasal cavity administration device that the present invention proposes includes inner catheter and is sheathed onOuter catheter outside described inner catheter, the port of export of described outer catheter is used to the port of export of described inner catheterStretching into nasal cavity, the port of export of described inner catheter is formed when stretching out the port of export of described outer catheter towards predeterminedThe structure of direction bending, and the arrival end of described inner catheter is for being connected with medicine applying device.
Preferably, described inner catheter is shape memory plastic part.
Preferably, the wall thickness of the tube wall of the described predetermined direction side of described inner catheter is less than described inner catheterThe wall thickness of the tube wall with described predetermined direction opposite side.
Preferably, described deep nasal cavity administration device also includes for making described inner catheter and described outer catheterThe mutually locking member of locking.
Preferably, described locking member is that be positioned at described inner catheter with described predetermined direction opposite side.
Preferably, described deep nasal cavity administration device also includes the confession being arranged at the arrival end of described inner catheterMedicine interface block and be arranged at the handle of arrival end of described outer catheter；Described locking member includes can phaseThe groove mated mutually and projection, described groove is arranged at described for the one in medicine interface block and described handleOn, and described projection is arranged at in the another one in medicine interface block and described handle.
Preferably, the side contrary with described predetermined direction of described outer catheter is provided with tag slot；And/or,The graduation apparatus stretching into the degree of depth for showing described outer catheter it is provided with on the outer surface of described outer catheter.
Preferably, described deep nasal cavity administration device also includes the gold being arranged at the port of export of described outer catheterBelong to labelling part.
Preferably, described deep nasal cavity administration device also includes being surrounded on outside described outer catheter and near describedAir bag that the port of export of outer catheter is arranged and for the gas tube of described airbag aeration.
Preferably, described deep nasal cavity administration device also includes the first metal arranged around described outer catheterCircle and the second quoit, described first quoit and described second quoit are all from the appearance of described outer catheterFacing out prominent, described air bag is arranged between described first quoit and described second quoit.
In technical solution of the present invention, the port of export of inner catheter can be when stretching out the port of export of outer catheter towards in advanceDetermine direction bending, and the arrival end of inner catheter is for being connected with medicine applying device, thus use deep nasal cavity to giveWhen patient is treated by medicine equipment, it is possible to make the port of export of inner catheter bend towards intracranial direction, with logicalCross medicine applying device through inner catheter injection of medicine in deep nasal cavity.When patient regains consciousness, utilize deep nasal cavity toMedicine equipment can be administered in deep nasal cavity painless and hurtless measure (Noninvasive), make medicine directly andAccurately attain the position that need to treat.These medicines can be anesthetics, hormone or antibiotic, thus playsThe effect of blocking-up dish Hubei Province neuroganglion and around adjacent nerve, or, medicine can arrive nasal sinuses at nasal cavityThe opening in deep, makes medicine directly play a role.Further, deep nasal cavity administration device can also be toDeep nasal cavity is carried out by deep nasal cavity perfusion normal saline, the pathological changes to this position, such as rhinitis,Sinusitis, atypical headache or localized cancer pathological changes, play relieving the pain caused by diseases and therapeutical effect.This technologyDeep nasal cavity administration device in scheme, simple in construction, accurate positioning, painless noinvasive, low price,Easy to use, curative effect certainly, oneself can be used by patient after instructing at home.It addition, same patientSame deep nasal cavity administration device can be reused and carry out deep nasal cavity administration, and it is deep to carry out nasal cavityThe whole process time of short duration (only about 10 minutes) that portion is administered.
Detailed description of the invention
Below in conjunction with the accompanying drawing in embodiment of the present invention, to the technical scheme in embodiment of the present inventionIt is clearly and completely described, it is clear that it is real that described embodiment is only the part of the present inventionExecute mode rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this areaThe every other embodiment that art personnel are obtained under not making creative work premise, broadly falls into thisThe scope of invention protection.
It is to be appreciated that directional instruction in embodiment of the present invention (such as upper and lower, left and right,It is forward and backward ...) it is only used for explanation phase under a certain particular pose (as shown in drawings) between each partsTo position relationship, motion conditions etc., if this particular pose changes, then directionality indicates alsoChange the most therewith.
It addition, in the present invention such as relating to the description of " first ", " second " etc. is only used for describing purpose,And it is not intended that indicate or imply its relative importance or the implicit number indicating indicated technical characteristicAmount.Thus, define " first ", the feature of " second " can be expressed or implicitly include at leastOne this feature.In describing the invention, " multiple " are meant that at least two, such as two,Three etc., unless otherwise expressly limited specifically.
In the present invention, unless otherwise clearly defined and limited, term " connect ", " fixing " etc.Should be interpreted broadly, such as, " fixing " can be fixing connection, it is also possible to is to removably connect, orIntegral；Can be to be mechanically connected, it is also possible to be electrical connection；Can be to be joined directly together, it is also possible to pass throughIntermediary is indirectly connected to, and can be connection or the interaction relationship of two elements of two element internals,Unless otherwise clear and definite restriction.For the ordinary skill in the art, can be as the case may beUnderstand above-mentioned term concrete meaning in the present invention.
It addition, the technical scheme between each embodiment of the present invention can be combined with each other, but must beBased on those of ordinary skill in the art are capable of, when technical scheme combination occur conflicting orWill be understood that when cannot realize that the combination of this technical scheme does not exists, the most not in the protection of application claimsWithin the scope of.
Before introducing the detailed description of the invention of the present invention, first introduce nasal cavity 6 and the oral cavity 5 of human bodyStructure.Refer to Fig. 1 to Fig. 2, include in the nasal cavity 6 of human body superior nasal concha 9, middle nasal concha 8, concha nasalis inferior 7,Nasal bone 10, sphenopalatine crypts 12 (including rear sphenopalatine crypts 11), ganglion pterygoplatinum 13, superior nasal meatus 16, inNasal meatus 15, inferior nasal meatus and nostril 17 etc., include in the oral cavity 5 of human body mouth 1, tooth 2, tongue 3 andMaxillary 4 etc..From figure 2 it can be seen that the cotton swab 14 of straight bar shape cannot arrive deep nasal cavity, i.e. straightThe administration device of strip cannot be pointed to sphenopalatine crypts 12 and the ganglion pterygoplatinum 13 etc. of deep nasal cavity to be carried outIt is administered.
Therefore, the present invention proposes a kind of deep nasal cavity administration device be easy to and be administered deep nasal cavity,Aim at and deep nasal cavity is carried out the painless administration of noinvasive accurately.
In one embodiment of the invention, as shown in Fig. 3 to Fig. 5 A, this deep nasal cavity administration device bagInclude inner catheter 19 and the outer catheter 20 being sheathed on outside inner catheter 19, the port of export of outer catheter 20 and inner catheter 19The port of export be used to stretch into nasal cavity, the port of export of inner catheter 19 is when stretching out the port of export of outer catheter 20Form the structure towards predetermined direction bending, and the arrival end of inner catheter 19 is for being connected with medicine applying device.At thisIn inventive technique scheme, due to inner catheter 19 the port of export can when stretching out the port of export of outer catheter 20 courtPredetermined direction bends, and the arrival end of inner catheter 19 is for being connected with medicine applying device, thus is using nasal cavity deepWhen patient is treated by portion's administration device, it is possible to make the port of export of inner catheter 19 bend towards intracranial direction,With by medicine applying device through inner catheter 19 injection of medicine in deep nasal cavity.
Wherein, the length of inner catheter 19 is more than the length of outer catheter 20, and inner catheter 19 can in outer catheter 20Telescopic moving, and, outer catheter 20 is defaulted as according to medicine with the port of export with the arrival end of inner catheter 19The flow direction determines, it is arrival end that medicine flows into one end of deep nasal cavity administration device, and medicine is from deep nasal cavityOne end that administration device flows out is the port of export.The port of export of inner catheter 19 is provided with a drug delivery port 25, usesTime drug delivery port 25 enter deep nasal cavity, medicine needs agents area from what drug delivery port 25 sprayed to deep nasal cavity.SeparatelyOutward, medicine applying device can be syringe or other injection equipment etc., sees Fig. 4, supplies in the present embodimentMedicine device is the first syringe 28.
When patient regains consciousness, utilize the deep nasal cavity administration device can painless and hurtless measure (Noninvasive)Ground is administered in deep nasal cavity, makes medicine directly reach the position that need to treat.These medicines can be anesthetics,Hormone or antibiotic, thus play dish Hubei Province neuroganglion and the effect of the adjacent nerve of surrounding of blocking, or,Medicine can arrive the nasal sinuses opening at deep nasal cavity, makes medicine directly play a role.Further, noseDeep nasal cavity can also be carried out by deep, chamber administration device to deep nasal cavity perfusion normal saline, rightThe pathological changes at this position, such as rhinitis, sinusitis, atypical headache or localized cancer pathological changes, play and subtractHypopathia pain and therapeutical effect.Deep nasal cavity administration device in the technical program, simple in construction, positioning accurateStandard, painless noinvasive, low price, easy to use, curative effect certainly, can by patient at home after instructingOneself uses.It addition, same patient can reuse same deep nasal cavity administration device carries out nasal cavityDeep is administered, and the whole process time carrying out deep nasal cavity administration of short duration (only about 10 minutes).
Wherein, owing to needing that the port of export of outer catheter 20 is stretched into nasal cavity, outer catheter 20 is moderate by hardnessMaterial manufacture, thus while avoiding damage to nasal mucosa, additionally it is possible to inner catheter 19 is supported.It addition, in order to enable the port of export of inner catheter 19 when stretching out the port of export of outer catheter 20 towards predetermined directionBending, can make inner catheter 19 be made up of shape memory plastic, i.e. inner catheter 19 is shape memory plasticPart.Shape memory plastic is a kind of novel thermal sensitivity functional material, and it is in the above uniform temperature of room temperatureLower deformation, and can at room temperature fix deformation and long-term storage, when being warming up to a certain specified temp again,It can quickly return to deform the macromolecular material of front shape.The inner catheter 19 being made up of shape memory plastic,Nasal cavity at human body is affected by body temperature, and can when stretching out in outer catheter 20 according toReservation shape bends, i.e. to predetermined direction bend, inner catheter 19 can move ahead in the middle of nasal meatus andThe not nasal mucosa of injured patients.It should be noted that inner catheter 19 can be all by shape-memory material systemBecome, it is also possible to only allow one section that needs to stretch out in outer catheter 20 to be made up of shape-memory material, i.e. at thisIn embodiment, inner catheter 19 can be partly that shape memory element can also generally shape memory element, manufactureBusiness can manufacture inner catheter 19 according to the selection that needs of user (doctor or patient).
In addition to the above-mentioned method using shape memory plastic manufacture inner catheter 19, other modes are also had to makeInner catheter 19 can bend towards predetermined direction when stretching out the port of export of outer catheter 20.Such as, otherIn embodiment, the wall thickness of the tube wall of the predetermined direction side of inner catheter 19 less than inner catheter 19 with predeterminedThe wall thickness of the tube wall of side in opposite direction, the circumference along inner catheter 19 is formed with Wall-Thickness Difference, so that interiorConduit 19 bends towards predetermined direction (side that wall thickness is less) automatically when losing the support of outer catheter 20.It should be noted that inner catheter 19 has equally been completely formed Wall-Thickness Difference, it is also possible to only allow needs from outwardOne section stretched out in conduit 20 is formed with Wall-Thickness Difference, and manufacturer can need and manufacturing process according to userManufacture inner catheter 19.
Further, in order to ensure the practical situation towards predetermined direction bending with human body nasal cavity of inner catheter 19Corresponding and do not occur direction to change, deep nasal cavity administration device also includes making inner catheter 19 and outer catheter20 locking members mutually locked, locking member is positioned at the side opposite to the predetermined direction of inner catheter 19.ByIt is positioned at side opposite to the predetermined direction in locking member, nasal cavity can can't see by locking memberIn the case of portion, determine the bending direction of inner catheter 19 intuitively.Further, in the outlet of inner catheter 19After end stretches out in the port of export of outer catheter 20, locking member makes inner catheter 19 interlock with outer catheter 20 phaseTightly, so that inner catheter 19 and outer catheter 20 will not occur the relative movement of circumference, also will not occurAxial relative movement such that it is able to guarantee the predetermined bending direction of inner catheter 19 and the knot of deep nasal cavityStructure is consistent, i.e. make inner catheter 19 bend towards deep nasal cavity (intracranial direction).
Wherein, as one preferred embodiment, as shown in Fig. 3, Fig. 4 and Fig. 5 B, deep nasal cavityAdministration device also includes the confession medicine interface block 27 being arranged at the arrival end of inner catheter 19 and is arranged at outer leadingThe handle 26 of the arrival end of pipe 20.Wherein, it is tubular structure for medicine interface block 27 and handle 26, ifPut and medicine applying device (the i.e. first syringe 28) can be facilitated to inject medicine in inner catheter 19 for medicine interface block 27Thing, and handle 26 is set user can be facilitated to capture and operate deep nasal cavity administration device.Further, for medicineInterface block 27 is the syringe interface of standard model, can engage the syringe of all standard specificationss.
Further, locking member can be directly arranged on outer catheter 20 and inner catheter 19, it is also possible toIt is arranged at on medicine interface block 27 and handle 26.As one preferred embodiment, locking member bagIncluding the groove 36 and projection 35 that can be mutually matched, groove 36 is arranged at for medicine interface block 27 and handleIn one in 26, and projection 35 is arranged in the another one supplied in medicine interface block 27 and handle 26, withThe movement of inner catheter 19, groove 36 is the most close to each other with projection 35 until the most chimeric, and makesInner catheter 19 is mutually locked with outer catheter 20.Specifically, as shown in Fig. 3, Fig. 4 and Fig. 5 B, projection35 are arranged at on medicine interface block 27, and groove 36 is arranged on handle 26.It addition, outer catheter 20Side opposite to the predetermined direction is provided with tag slot 30, in other words, handle 26 be provided with groove 36Side be additionally provided with tag slot 30.Tag slot 30 can make the needs of user's definitely inner catheter 19The predetermined direction of bending, and guarantee that inner catheter 19 can enter nasal cavity according to predetermined direction smoothly when bendingDeep.Wherein, in the present embodiment, tag slot 30 is preferably triangular marker.
It addition, deep nasal cavity administration device also includes the metal marker part being arranged at the port of export of outer catheter 20,This metal marker part can play and determine the deep nasal cavity administration device position at nasal cavity under x-ray fluoroscopyEffect.Wherein, metal marker part can be metal derby or the metallic channel of the port of export embedding outer catheter 20,Can also be for embedding the becket of the port of export of outer catheter 20.Even, metal marker part herein is alternativelyThe first quoit 22 hereinafter mentioned, the first quoit 22 outwardly highlighting from outer catheter 20Height be about 2mm, the first quoit 22 can play determine under x-ray fluoroscopy deep nasal cavity toMedicine equipment is in the effect of the position of nasal cavity.
Additionally, as shown in Figure 8 and Figure 9, deep nasal cavity administration device also includes being surrounded on outside outer catheter 20And near outer catheter 20 the port of export arrange air bag 33 and for air bag 33 inflation gas tube 34.Air bag 33 is the emulsion capsule pipe of annular, and the internal diameter of air bag 33 is less than the external diameter of outer catheter such that it is able to makeAir bag 33 is immediately around outside outer catheter 20.Gas tube 34 is a very thin conduit, gas tube 34Can arrange parallel with outer catheter 20 (as shown in Figure 5 B, the outer surface of handle 26 offers groove 32,Gas tube 34 can be disposed in groove 32), it is possible to separately positioned with outer catheter 20.Gas tube 34One end connects air bag 33 and the other end connects the second syringe 29, in order to inject air in air bag 33.When cancer patient needs nose perfusion chemotherapy medicine, or rhinitis or sinusitis client need clean treatment noseDuring chamber, the second syringe 29 can be used to inflate in air bag 33 through gas tube 34 such that it is able to blockingNasal cavity, prevents medicine from backflowing, and makes major part medicine can act on disease sites.During use air capacity according toHuman body difference selects, and at the end of use, pulls out the second syringe 29, makes the air stream in air bag 33Go out.Need not use the patient of air bag 33, need not be to air bag 33 when using deep nasal cavity administration deviceInterior inflation, to reduce expenses.
Deep nasal cavity administration device also includes the first quoit 22 and the second gold medal arranged around outer catheter 20Genus circle 21, the first quoit 22 and the second quoit 21 all outwardly highlighting from outer catheter 20,Second quoit 21 is about 2mm from the outwardly prominent height of outer catheter 20, and the first gold medalBelonging to and be separated by 0.8～1.2cm between circle 22 and the second quoit 21, air bag 33 is arranged at the first quoit 22And between the second quoit 21.Wherein, in a preferred embodiment, the first quoit 22 and secondIt is separated by 1cm between quoit 21.First quoit 22 and the second quoit 21 all can play at X-rayThe effect in the position of nasal cavity of the deep nasal cavity administration device is determined, simultaneously by by the first metal under perspectiveCircle 22 and the second quoit 21 are arranged at the both sides of air bag 33 and air bag 33 can play position-limiting action,Thus be better protected from air bag 33 and slip.
Further, as one preferred embodiment, the outer surface of outer catheter 20 is provided with forThe graduation apparatus stretching into the degree of depth of display outer catheter 20.By the graduation apparatus on outer catheter 20, user canJudge that outer catheter 20 stretches into the degree of depth of nasal cavity intuitively such that it is able to grasp exactly by inner catheter 19 fromThe opportunity released in outer catheter 20.
It addition, the present invention also provides for a kind of deep nasal cavity utilizing above-mentioned deep nasal cavity administration device to carry outMedication, wherein, described deep nasal cavity medication comprises the following steps:
S1, the port of export of outer catheter 20 is stretched into nasal cavity；
S2, promotion inner catheter 19, make the port of export of inner catheter 19 stretch out also from the port of export of outer catheter 20Bend to intracranial direction；
S3, the arrival end of medicine applying device with inner catheter 19 is connected, and by medicine applying device through inner catheter 19 toInjection of medicine in deep nasal cavity.
Wherein, the port of export of inner catheter 19 can be when stretching out the port of export of outer catheter 20 towards predetermined directionBend, and the arrival end of inner catheter 19 can be connected with medicine applying device, thus set using deep nasal cavity to be administeredFor when patient is treated, it is possible to make the port of export of inner catheter 19 bend towards intracranial direction, to pass throughMedicine applying device is through inner catheter 19 injection of medicine in deep nasal cavity.When patient regains consciousness, utilize deep nasal cavity toMedicine equipment can be administered in deep nasal cavity painless and hurtless measure (Noninvasive), makes medicine directly reachTo the position that need to treat.Further, deep nasal cavity administration device can also irrigate normal saline to deep nasal cavityDeep nasal cavity is carried out, the pathological changes to this position, such as rhinitis, sinusitis, atypical headPain or localized cancer pathological changes, play relieving the pain caused by diseases and therapeutical effect.
Further, in step sl, because some patients is more sensitive, outer catheter 20 is being stretched into nasal cavityBefore Nei, first inject appropriate anesthetics to nasal cavity, the most again the port of export of outer catheter 20 is stretched into nasal cavityIn.Furthermore it is also possible to first measure outer catheter 20 can enter the degree of depth of nasal cavity, then going out outer catheter 20Mouth end stretches into nasal cavity, and makes outer catheter 20 reach or be slightly smaller than the degree of depth of this pre-test.
Specifically, when using deep nasal cavity administration device to carry out deep nasal cavity administration, patient is first made to lieSleeping and face is upwards.Before treating, first inner catheter 19 is retracted, make the port of export of inner catheter 19Flush with the port of export of outer catheter 20.Then, use the graduation apparatus on outer catheter 20, survey outside nasal cavityAmount nasal cavity exports to the distance of the nasion, slowly the port of export of outer catheter 20 is extend into disease further according to this distanceIn the nasal cavity of people.Wherein, Fig. 6 be the port of export of outer catheter 20 is stretched into nasal cavity and inner catheter 19 not yet fromThe state stretched out in outer catheter 20.Now, note observing tag slot 30 (the i.e. triangle mark on handle 26Note) and projection 35 and the position of groove 36, the direction contrary with tag slot 30 is that inner catheter 19 is predeterminedBending direction, needs the port of export ensureing inner catheter 19 to bend towards intracranial direction (i.e. deep nasal cavity).
Wherein, for not can determine that the some patients stretching into the degree of depth of outer catheter 20, it is possible to use x-ray fluoroscopyOr Digital Subtraction (DSA) technology, observe outer catheter 20 in the position of nasal cavity.The outlet of outer catheter 20End is provided with the first quoit 22 and the second quoit 21, and the first quoit 22 and the second quoit 21 will notX-ray thoroughly, it can be observed that its position, according to the first quoit 22 and position of the second quoit 21,Release inner catheter 19, make inner catheter 19 enter superior nasal meatus 16, and inject to deep nasal cavity through drug delivery port 25Medicine.Fig. 7 is that the port of export of outer catheter 20 stretches into nasal cavity and inner catheter 19 stretches out in outer catheter 20State.The drug delivery port 25 of inner catheter 19 points to the top of middle nasal concha 8, can enter after drug injectionIn the sphenopalatine crypts 12 of nasal meatus 16, anaesthetize infiltration ganglion pterygoplatinum 13.
In figs. 8 and 9, deep nasal cavity administration device also includes air bag 33 and gas tube 34.In some feelingsWhen condition, such as chronic sinusitis or nasal cavity have cancer, need to inject the medicine that dosage is more, theseMedicine can backflow in nasal cavity.Block nasal cavity by inflation in air bag 33, be possible to prevent medicine to backflow,Owing to air bag 33 is the most soft, from without injuring nasal mucosa.Simply there are some patients may be to latex systemProduct allergy, before treating, doctor or nurse need to inquire the allergies of patient, understand it previouslyWith or without latex allergy history, to determine whether to be suitable for application air bag 33.
Cluster headache, migraine and disease of nasal sinus caused by ganglion pterygoplatinum disorder, in the whole nationMorbidity scope is wide, and according to Epidemiological study, migraine patient accounts for the 9.3% of total population, sinusitis patientHave about 5%.The feature of these patients is that the age is light, and the headache morbidity persistent period is short, typically at several hoursBy about 3 days, can have every year and fall ill several times.With age, the symptom of many patients fades away.So, control headache syndromes and reduce the main feature that patient's misery is associated treatment.The nasal cavity of the present inventionDeep administration device simple in construction, and, the deep nasal cavity medication of the present invention easily uses, patientCan be learnt oneself under the guidance of doctors and nurses use.When disease symptoms (such as headache) occurs,Patient oneself can injection of medicine treatment at home.If symptom reappears, can be with repeated application.WithEating analgesic drug product to compare, this deep nasal cavity medication registration, dosage is little, will not exist because of medicineCylinder accumulation and produce the side effect such as toxicity, addicted and drug resistance.
It addition, compared with acupuncture and radio frequency method, the deep nasal cavity medication of the present invention has riskLow and noinvasive and do not damage the feature of ganglion pterygoplatinum.Compared with using nasal cavity sight glass, the present invention'sDeep nasal cavity administration device, cost of use is low, simple to operate, is easy to learn and use.Because headache, migraineAnd sinusitis is commonly encountered diseases, frequently-occurring disease, change according to the season time sickness rate height in spring and autumn, and many patients are in localityThe medical treatment in clinic and township level commune hospital.These hospital conditions are simple and crude, do not have special department of otorhinolaryngology with bigType instrument, the deep nasal cavity administration device of the present invention is more suitable for these hospitals and uses.Further, the present inventionDeep nasal cavity administration device simple to operate, many patients can decrease contact hospital with Self-operatingLoaded down with trivial details link.
The foregoing is only the preferred embodiment of the present invention, not thereby limit the scope of the claims of the present invention,Every under the inventive concept of the present invention, utilize the equivalent structure that description of the invention and accompanying drawing content are madeConversion, or directly/be indirectly used in other relevant technical fields and be included in the patent protection model of the present inventionIn enclosing.