A kind of micropin dosing paster containing separate type medicine storing bagTechnical field
The present invention relates to a kind of transdermal infusion device, particularly relate to a kind of micropin dosing paster containing separate type medicine storing bag.
Background technology
Drug therapy is a kind of common medical procedure, and medicine enters the main mode of movement of human body and includes injection and be administered orally, and both modes all have some limitations.Medicine is likely to be due to oneself's metabolism in oral period and inactivates thus lose curative effect；Subcutaneous injection needs trained personnel to implement, and brings the risk of unavoidable pain and infection to sufferer, makes troubles to patient.In recent years, micropin administering mode increasingly attracts the concern of people.Micropin is that the micron order of a kind of similar injection needle is hollow or solid needle, typically uses single crystal silicon material, metal or high molecular polymer to be made.It can not touch pain nerve through horny layer just, does not the most create a painful feeling and the damage of skin corium playing drug osmotic effect simultaneously.
Solid microneedles can be divided into medicine carrying solid microneedles and not medicine carrying solid microneedles two class.
Wherein medicine carrying solid microneedles uses and first wraps the administering mode pricked afterwards, i.e. remaking after packaging medicine on the outer wall of micropin makes drug molecule discharge for skin, the drug-supplying system of this form does not has drug-reservoir, while micropin punctures keratodermatitis, medicine is passed in human body by synchronization, is directly released into targeted cells or infected tissue；Medicine carrying micropin does not uses and first pricks the administering mode pasted afterwards, after i.e. micropin acts on skin, produces micron-sized hole, thus sets up a large amount of micron-sized micro-channel, then use medicine patch on horny layer, and medicine will be directed to internal by micro-channel.
Although solid microneedles has many advantages, but is not widely used in medical practice.The drug loading of medicine carrying solid microneedles is the lowest, can affect the acutance of needle body after packaging medicine, and needle body can be caused can not to thrust skin smoothly.After medicine carrying solid microneedles does not acts on skin, can temporarily break the barrier action of keratodermatitis, set up substantial amounts of skin micro-channel.But after micropin removes, along with the recovery of stratum corneum barrier function while skin recovery normal condition, this can stop medicine to continue through skin, so the active drug conveying capacity that medicine carrying solid microneedles can not realize is extremely limited.
At present, compared to solid microneedles, empty micropin is considered as one more promising micropin drug delivery structure.Empty micropin is the form conveying medicine using microinjection, comprises the hollow channel of a micron level inside the needle body of empty micropin, and under the driving of flow stream pressure, medicine can be carried by hollow channel.Empty micropin not only can realize the medicine conveying of long-time larger dose, and the acutance of empty micropin needle body can also be maintained in the level effectively puncturing keratodermatitis.
Above-mentioned advantage based on empty micropin, the present invention devises a kind of flexible micropin dosing paster containing separate type medicine storing bag, micropin in dosing paster have employed empty micropin, it is ensured that realizes lasting medicine conveying in the case of effectively puncturing keratodermatitis, thus increases the conveying capacity of medicine.It addition, dosing paster of the present invention uses flexible biological material to make as substrate, it is ensured that the skin-friendly of dosing paster, be suitable to human body laminating skin and use.What is more important, dosing paster of the present invention have employed the design of separate type medicine storing bag, can replace medicine storing bag according to different drug delivery demands, thus greatly improve the versatility of dosing paster of the present invention.
Summary of the invention
The present invention describes a kind of flexible micropin dosing paster containing separate type medicine storing bag made based on polymer.Invent described a kind of flexible micropin dosing paster containing separate type medicine storing bag to include: an interchangeable medicine storing bag of separate type；Integrate microneedle array and the medicine carrying end of microfluidic channel network for one；Integrate microneedle array and the loading end of microfluidic channel network and adhesive patches micropin dosing paster can being attached on skin for one.
A kind of flexible micropin dosing paster containing separate type medicine storing bag of the present invention is made up of flexible polymer, can well bend.User joint it is attached at during use, extruding and the stretching of flexible dosing paster are made the medicine carrying end of dosing paster and medicine storing bag deform upon by the bending utilizing joint, so that the syringe needle of medicine carrying end thrusts medicine storing bag, and pass through microfluidic channel network by medicament distribution to loading end；Then the passage formed on skin by the micropin of loading end is flowed into human body and completes loading.
A kind of flexible micropin dosing paster feature containing separate type medicine storing bag of the present invention is:
1. dimethyl siloxane (PDMS) is made up by overall structure of flexible polymer, has the characteristic of flexibility, pro-skin；
2. the control of loading is to be completed by the joint motions of user, and extruding and stretching that loading paster is produced by dependence arthrogryposis make medicine carrying end microneedle array puncture medicine storing bag, start the conveying of medicine；
3. the conveying of medicine is that the closing microfluidic channel by being integrated in flexible substrates completes；
4. medicine storing bag is separate type, can be replaced according to the demand of the medicine of conveying；
5. the micropin of medicine carrying end and loading end is internal containing being available for the passage that medicine circulates, and medicine can flow into microfluidic channel network by the passage within micropin and carry；
6. use SU-8 photoresist to make micropin to puncture skin and carry out medicine conveying.
A kind of flexible micropin dosing paster containing separate type medicine storing bag of the present invention has a following benefit:
Dosing paster bio-compatibility the most of the present invention is good, is not result in the untoward reaction such as allergy；
Dosing paster the most of the present invention is flexible, skin of can well fitting, and wear comfort is high；
Micropin on dosing paster the most of the present invention is hollow, and medicine can be avoided to be contaminated；
Dosing paster the most of the present invention uses micropin to carry out loading, the risk of superinfection reduce misery, avoiding, and uses simple, and ordinary people also can easily use；
The drug storage part of dosing paster the most of the present invention is separate type, can adaptive different loading demand, easy to use；
Dosing paster the most of the present invention uses the microfluidic channel closed to carry out medicine conveying, can avoid medicine pollution in transmitting procedure.
Accompanying drawing explanation
Fig. 1 is a kind of micropin dosing paster overall schematic containing separate type medicine storing bag.
Fig. 2 is separate type medicine storing bag side view.
Fig. 3 is separate type medicine storing bag top view.
Fig. 4 is separate type medicine storing bag upward view.
Fig. 5 is the medicine carrying end-view of micropin dosing paster.
Fig. 6 is the medicine carrying end top view of micropin dosing paster.
Fig. 7 is the loading end-view of micropin dosing paster.
Fig. 8 is the loading end upward view of micropin dosing paster.
Fig. 9 is that a kind of micropin dosing paster containing separate type medicine storing bag is applied to the schematic diagram on elbow joint.
Detailed description of the invention
The present invention is achieved by the following technical solutions:
A kind of flexible micropin dosing paster containing separate type medicine storing bag of the present invention, as it is shown in figure 1, include: an interchangeable medicine storing bag of separate type 1；Integrate microneedle array and the medicine carrying end 2 of microfluidic channel network for one；Integrate microneedle array and the loading end 3 of microfluidic channel network, and the adhesive patches 4 micropin dosing paster can being attached on skin for one.For the simplicity described, the one side of contact skin is referred to as " bottom surface " by the present invention, another side is referred to as " end face ".
The interchangeable medicine storing bag of separate type of the present invention 1, made by dimethyl siloxane (PDMS), such as Fig. 2, shown in 3 and 4, including a flexible substrates 5, the drug storage space 6 of one elliposoidal, a frame 7 being positioned at medicine storing bag bottom surface connects sheet 8 with the viscosity being produced on frame lower surface.Wherein: flexible substrates 5 maintains whole separate type interchangeable medicine storing bag 1 Stability Analysis of Structures；Elliposoidal drug storage space 6 is for storing the medicine of required injection；Frame 7 is for isolating the microneedle array 12 of drug storage space 6 and medicine carrying end 2, and to avoid, the microneedle array 12 when not using this paster is unexpected pokes drug storage space 6；The viscosity being produced on frame 7 end face connects sheet 8 for inventing the bonding of the interchangeable medicine storing bag of described separate type 1 and medicine carrying end 2.
Further, viscosity connection sheet 8 surface being produced on medicine storing bag frame lower surface of the present invention covers one layer of release paper 9.
Medicine carrying end 2 of the present invention, as illustrated in Figures 5 and 6, including a flexible substrates 10, one microfluidic channel network being integrated within substrate 10 11, one that be connected with microfluidic channel network 11, be positioned at 5 × 5 microneedle arrays 12 of medicine carrying end 2 end face, a frame 15 being positioned at medicine carrying end 2 end face and be produced on the viscosity of frame 15 upper surface and connect sheet 13.Wherein, flexible substrates 10 is the main body of flexible micropin dosing paster of the present invention, for maintaining the Stability Analysis of Structures of whole dosing paster；Microfluidic channel network 11 is for being delivered to loading end 3 by medicine from medicine carrying end 2；Microneedle array 12 is used for puncturing medicine storing bag 1；Frame 15 is for isolating the microneedle array 12 of drug storage space 6 and medicine carrying end, and to avoid, the microneedle array 12 when not using paster of the present invention is unexpected pokes medicine storing bag 1；The viscosity being produced on frame 15 end face connects sheet 13 for inventing the bonding of the interchangeable medicine storing bag of described separate type 1 and medicine carrying end 2.
Further, viscosity connection sheet 13 surface being produced on medicine carrying end 2 frame 15 upper surface of the present invention covers one layer of release paper 14.
Loading end 3 of the present invention, as shown in FIG. 7 and 8, be in same substrate 10 with medicine carrying end 2, further comprises a microfluidic channel network being integrated within substrate 10 16, one that be connected with microfluidic channel network 16, be positioned at 5 × 5 microneedle arrays 17 of loading end 3 bottom surface.Wherein: microfluidic channel network 16 is delivered to the medicine of loading end 3 from medicine carrying end 2 for receiving and distributes to each syringe needle of microneedle array 17；Microneedle array 17 is used for puncturing skin, forms the passage being available for drug osmotic.
Adhesive patches 4 of the present invention, is positioned at the bottom surface 18 of flexible micropin dosing paster containing separate type medicine storing bag, covers other parts in addition to loading end microneedle array 17 position, and adhesive patches 4 surface covers one layer of release paper 19 before use.
Further, two 5 × 5 microneedle arrays of the present invention are made by SU-8 photoresist.
A kind of micropin dosing paster occupation mode containing separate type medicine storing bag of the present invention is as follows:
1., before using, medicine storing bag and dosing paster are to separate；
When 2. preparing to use, the release paper 9 of medicine storing bag 1 bottom surface of tearing and the release paper 14 of dosing paster medicine carrying end 2 end face, and medicine storing bag 1 is connected with the medicine carrying end 2 of dosing paster；
Tear the most subsequently the release paper 19 of dosing paster bottom surface；
Being attached at user joint when 4. using, medicine carrying end 2 is positioned at arthrogryposis, as shown in Figure 9；
5. when arthrogryposis, can be to the extruding of flexible dosing paster and stretching, the medicine carrying end 2 and the medicine storing bag 1 that make dosing paster deform upon, so that the microneedle array 12 of medicine carrying end 2 thrusts medicine storing bag 1, and pass through microfluidic channel network 11 by medicament distribution to loading end 3；Then the passage formed on skin by the microneedle array 17 of loading end 3 is flowed into human body and completes loading.
Although detailed description of the invention illustrative to the present invention is described above; so that those skilled in the art understand the present invention; it is to be understood that; the invention is not restricted to the scope of detailed description of the invention; from the point of view of those skilled in the art; as long as various changes limit and in the spirit and scope of the present invention that determine, these changes are apparent from, and all utilize the innovation and creation of present inventive concept all at the row of protection in appended claim.