Summary of the invention
For the problems referred to above, it is an object of the invention to provide a kind of volume little, radiate little, carotid artery can be propped up simultaneouslyPressure difference monitoring device based on carotid stents that the blood pressure of frame blood vessel is monitored in real time and method thereof.
For achieving the above object, the present invention takes techniques below scheme: a kind of pressure difference based on carotid stents is monitoredDevice, it is characterised in that this monitoring device includes a carotid stents, two integrated circuits and an external processing apparatus；Described carotid stents uses as antenna, and integrated circuit described in two is respectively fixedly disposed at the blood of described carotid stentsAt the entrance and exit of pipe；Each described integrated circuit all includes an energy supply module, a pressure transducer, one depositsReservoir, a data processor and one first radio-frequency (RF) receiving and transmission module, each described energy supply module is for for described integratedCircuit is powered；The blood pressure signal detected is transmitted to described data processor by described pressure transducer through described memorizer,Blood pressure signal is converted into digital signal by described data processor, and numeral is believed by described first radio-frequency (RF) receiving and transmission moduleNumber it is transferred to described external processing apparatus through described carotid stents.
Further, described external processing apparatus includes launching antenna, reception antenna, the second radio-frequency (RF) receiving and transmission module, processDevice, transport module and work station, by described integrated in described transmitting sky alignment body of described second radio-frequency (RF) receiving and transmission moduleCircuit transmission electromagnetic transmission energy, receives the described integrated circuit blood pressure to external transmission through described reception antenna simultaneouslySignal, the blood pressure signal received is sent to described work by described radio-frequency (RF) receiving and transmission module through described processor and transport moduleStand.
Further, described carotid stents includes plural bracing structure and some longitudinal support structure, oftenBracing structure described in one is bent to form ring support by a tinsel, passes through described in adjacent two between ring supportSome described longitudinal support structure being crisscross arranged are fixing to be connected, and forms network structure after making support strut, and described neck movesPulsation frame is configured to by two isometric joints, and the one end often saving described support is all connected with ic output described in,The other end often saving described support is respectively arranged with insulant.
Further, described ring support uses sinusoidal configuration or sawtooth waveforms structure.
Further, described carotid stents is set to as resonant frequency f of antenna:
In formula, N be the quantity of ring support, n be the fluctuating quantity of waveform in ring support, l be the length of longitudinal support structureDegree, C1、C2And C3It is positive coefficient.
Further, integrated circuit described in two is arranged on a string configuration, and strip integrated circuit is along described carotid arterySupport is axial arranged.
Further, each described integrated circuit all uses segmentation structure, and stagewise integrated circuit is along carotid stents axleTo layout.
Further, each described integrated circuit all uses square structure, is wrapped in its outside biological compatibility shellUse circular configuration.
Further, each described integrated circuit all uses loop configuration, annular integrated circuit place plane to move with described neckThe tangent plane of pulsation frame is parallel.
A kind of monitoring method based on described pressure difference monitoring device, it is characterised in that include herein below: 1) arrangeThe one pressure difference monitoring including pressure transducer, data processor, the first radio-frequency (RF) receiving and transmission module and external processing apparatusDevice, wherein, external processing apparatus include reception antenna, the second radio-frequency (RF) receiving and transmission module, processor, transport module andWork station；2) two pressure transducers gather the blood pressure signal at carotid stents blood vessel two ends respectively, and pass through phase respectivelyTransmit after answering data processor processes to the first radio-frequency (RF) receiving and transmission module, two first radio-frequency (RF) receiving and transmission module blood pressure letter to receivingIt is sent to external processing apparatus by antenna after number being modulated respectively；3) carotid stents that reception antenna will receiveThe blood pressure signal at blood vessel two ends is sent to work station after the second radio-frequency (RF) receiving and transmission module is demodulated and after the process of treated device.
Due to the fact that and take above technical scheme, it has the advantage that 1, the present invention includes carotid stents, twoIntegrated circuit and external processing apparatus, two integrated circuits are respectively fixedly disposed at the entrance and exit of carotid stents blood vesselCarotid stents blood pressure is monitored by place, it is possible to obtain blood pressure situation in carotid stents, by carotid stents bloodThe duty of carotid stents can be monitored by the pressure difference at pipe two ends effectively.2, due to the fact that and take realityTime detection mode, patient can understand self health status without going to hospital to do radiography, reduce cost and risk,Decrease the misery of patient, make the feedback that doctor obtains more quickly effectively.3, the present invention can implant at operative treatmentIntegrated circuit is implanted, it is to avoid the misery of patient's second operation while support.The present invention can be widely applied to support and is situated betweenEnter in the status monitoring of postoperative carotid disease.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is carried out detailed description.It should be appreciated, however, that being provided only more of accompanying drawingUnderstanding the present invention well, they should not be interpreted as limitation of the present invention.
As it is shown in figure 1, the pressure difference monitoring device based on carotid stents of the present invention, including a carotid stents,Two integrated circuits and an external processing apparatus；Carotid stents is used for carrying out energy and signal transmission, two collection as antennaBecoming circuit to be respectively fixedly disposed at the entrance and exit of carotid stents blood vessel, each integrated circuit all includes an energySupply module, a pressure transducer, a memorizer, a data processor and one first radio-frequency (RF) receiving and transmission module.Each energyAmount supply module is through being radiated by external processing apparatus by the first radio-frequency (RF) receiving and transmission module reception as the carotid stents of antennaTo internal electromagnetic wave, it is that on integrated circuit, miscellaneous part is powered by the way of radio frequency energy is collected.Pressure passesThe blood pressure signal detected transmission is stored to memorizer by sensor, data processor can from memory read data,It is translated into digital signal, and loads the information such as integrated circuit ID, timestamp, will by the first radio-frequency (RF) receiving and transmission moduleDigital signal to external processing apparatus, completes DATA REASONING through the antenna transmission as carotid stents, signal launches meritEnergy.Wherein, energy supply module can also use minicell as an alternative, in order to is directly each on integrated circuitParts are powered.
In a preferred embodiment, as in figure 2 it is shown, data processor can use NORDIC company to produceNRF51822 chip.This chip ADC switched pins J6 is connected in parallel two pressure transducers, and VDD power pins J1 is evenConnecing energy supply module, XC1, XC2 pin J37-J38 connects clock circuit, VDD_PA, ANT1, ANT2 pinJ30-J32 connects the first radio-frequency (RF) receiving and transmission module, and P0.01 pin J5 connects power sense circuit, DEC1 pin J39 warp3rd electric capacity C3 ground connection；Ground connection after VSS pin J33, J34 parallel connection, connects energy after VSS pin J33, J34 parallel connectionAmount supply module, the 4th electric capacity C4 in parallel between AVDD pin with VSS pin.DEC2 pin J29 is through the tenthElectric capacity C10 and EXP_GND pin J49 be connected after ground connection；VSS pin J13 ground connection, SWCLK pin is through the 3rd resistanceR3 ground connection.
Wherein, clock circuit includes the first electric capacity C1, the second electric capacity C2 and crystal oscillator X1, and crystal oscillator X1 controls end pin 1Through the second electric capacity C2 ground connection, crystal oscillator X1 outfan pin 2 is through the first electric capacity C1 ground connection；Crystal oscillator X1 controls end pinThe 1 XC1 pin J37 being additionally coupled to NRF51822 chip, crystal oscillator X1 outfan pin 2 is additionally coupled to NRF51822The XC2 pin J38 of chip.
Power sense circuit includes the first resistance R1, the second resistance R2 and electric capacity C13, and the first resistance R1 mono-terminates heightLevel (i.e. energy supply module), the first resistance R1 other end is through the second resistance R2 ground connection；It is positioned at the second resistance R2It is connected to NRF51822 by wire between two ends shunt capacitance C13, and the first resistance R1 other end and the second resistance R2The P0.01 pin J5 of chip.
In a preferred embodiment, as it is shown on figure 3, external processing apparatus include launch antenna, reception antenna,Second radio-frequency (RF) receiving and transmission module, processor, transport module and work station.By the second radio-frequency (RF) receiving and transmission module emitted sky alignmentInternal integrated circuit launches electromagnetic transmission energy, simultaneously and the integrated circuit that is received in antenna receiving body is to externalThe blood pressure signal sent；The treated device of blood pressure signal received, transport module are sent extremely by the second radio-frequency (RF) receiving and transmission moduleWork station, in case follow-up use.Wherein, work station can use the mobile terminal such as smart mobile phone, intelligent watch.
In a preferred embodiment, being provided with signal processing system in work station, signal processing system calculates installsThere is the pressure difference at the blood vessel two ends of carotid stents, and judge that whether the pressure difference obtained in Preset Time is at default modelIn enclosing, thus whether the blood vessel judging to be provided with carotid stents occurs in that the phenomenon of restenosis.
In a preferred embodiment, as shown in Figure 4, carotid stents includes plural bracing structure1 and some longitudinal support structure 2, each bracing structure 1 is bent to form ring support by a tinsel；AdjacentConnect by some longitudinal support structure 2 being crisscross arranged are fixing between two ring supports, after making support strut, form netShape structure.Ring support can use sinusoidal configuration or sawtooth waveforms structure.Carotid stents is by two isometric joint supportsConstituting, the one end often saving support is all connected with an ic output, two joints be configured to integrated circuit antennaThe two poles of the earth feed.Wherein, it is respectively arranged with insulant at the other end often saving support, is fixed by insulantThe steadiness of this joint supporting structure.In the present embodiment, when this carotid stents is as antenna, its radiance is more preferable,Frequency band is wider.
Carotid stents is set to as resonant frequency f of antenna:
In formula, N be the quantity of ring support, n be the fluctuating quantity of waveform in ring support, l be longitudinal support structureLength, C1、C2And C3It is positive coefficient.Wherein, N, n and l are the biggest, and resonant frequency is the least.During use, byIn not adjusting the size of carotid stents, so by adjusting waveform in quantity N of ring support, ring supportLength l of fluctuating quantity n and longitudinal support structure adjusts the resonant frequency of antenna.
In a preferred embodiment, each integrated circuit external is enclosed with biological compatibility shell.Each integratedCircuit can be fixed on outside carotid stents by a gim peg, and one end of gim peg is welded on the pad of integrated circuitOn, the other end links together with carotid stents outer wall；Gim peg is exposed to biological compatibility enclosure, rawThing compatibility shell is avoided that the rejection producing human body.Preferably, biological compatibility shell has the most pliable and the toughestProperty, can bend.The material of biological compatibility shell preferably employs polydimethylsiloxane (PDMS).During making,Can integrated circuit be put in a mold, with polydimethylsiloxane be filled with encapsulation, gim peg is left outside thusPrepare band biological compatibility shell and the integrated circuit of gim peg.
In a preferred embodiment, could be covered with biology at the solder joint of gim peg and carotid stents compatibleProperty medicine film.Owing to the welding of gim peg and carotid stents may destroy the biological compatibility outside carotid stentsShell, covers one layer of medicine film at gim peg and carotid stents weld, can prevent the rejection of human body from sending out furtherRaw.
In a preferred embodiment, each integrated circuit by flexible PCB and is formed on this flexible PCBThe each modular circuit chip being made up of wafer is made, to adapt to volumetric constraint, and can be with the change of carotid stents shapeIt is curved, but its length is less than carotid stents length, and in order to not block blood vessel, its sectional area is less than0.5mm×0.5mm。
In a preferred embodiment, two integrated circuits are arranged on a string configuration, strip integrated circuit edgeCarotid stents is axial arranged；Each integrated circuit all can use segmentation structure, and stagewise integrated circuit moves along neckPulsation frame is axial arranged, and integrated circuit external is enclosed with biological compatibility shell；Each integrated circuit all can useSquare structure, is wrapped in its outside biological compatibility shell and uses circular configuration；Each integrated circuit all can be adoptedBy loop configuration, annular integrated circuit place plane is parallel with the tangent plane of carotid stents.
The pressure difference monitoring device pair based on carotid stents using the present invention is described in detail below by specific embodimentThe detailed process that the blood pressure of patient is monitored:
1, two pressure transducers gather the blood pressure signal at carotid stents blood vessel two ends respectively, and pass through respective counts respectivelyTransmitting after processing according to processor to the first radio-frequency (RF) receiving and transmission module, the blood pressure signal received is divided by two first radio-frequency (RF) receiving and transmission moduleIt is sent to external processing apparatus by antenna after not being modulated.
2, the blood pressure signal at the carotid stents blood vessel two ends received is carried out by reception antenna through the second radio-frequency (RF) receiving and transmission moduleIt is sent to work station after demodulation and after the process of treated device.
In a particular embodiment, use the pressure difference monitoring device based on carotid stents of the present invention to carotid stentsDuty carries out the process detected:
The signal processing system being arranged in work station is by the pressure difference at the blood vessel two ends being provided with carotid stents of receptionCompare with preset value, if be in preset range at the pressure difference setting time arteria carotis interna stented vessel two ends,Determine that carotid stents duty is good, it is believed that the blood vessel being provided with carotid stents does not occur restenosis phenomenon；If the pressure difference at setting time arteria carotis interna stented vessel two ends is not in preset range, determine carotid stents workMake state and occur abnormal, it is believed that the blood vessel generation restenosis phenomenon of carotid stents is installed.Furthermore it is possible to according to obtainingThe pressure difference at the carotid stents blood vessel two ends taken further appreciates that the working condition of carotid stents as reference value.
The various embodiments described above are merely to illustrate the present invention, and the structure of the most each parts, connected mode and processing technology etc. are allCan be varied from, every equivalents carried out on the basis of technical solution of the present invention and improvement, the most should notGet rid of outside protection scope of the present invention.