CN105876129A - Fermented Chinese herbal medicine preparation replacing antibiotics and preparation method and application thereof - Google Patents

Abstract

The present invention belongs to the technical field of livestock and poultry Chinese herbal medicine additives, and discloses a fermented Chinese herbal medicine preparation replacing antibiotics and a preparation method and an application thereof. The preparation method comprises the following steps: fresh gingers, licorice, smoked plums, cassia twigs, white peony roots, honeysuckles, rhizoma atractylodis macrocephalae, cortex magnoliae officinalis, radix ophiopogonis, black beans and silkworm excrement are weighed, the weighed materials are mixed evenly, the mixture is crushed, the crushed mixture is sieved, the sieved mixture is sterilized, and the sterilized mixture is dried; the obtained Chinese herbal medicine powder and fermentation bacterium liquid are mixed evenly at a mass ratio of 100 : 2 to obtain bacteria containing Chinese herbal medicine powder; the bacteria containing Chinese herbal medicine powder and a bacterial fermentation medium are mixed evenly at a mass ratio of 50 : 3, then sterile water is added into the mixture at a solid-liquid ratio of 1 : 1, and the mixture is subjected to fermentation at 26 DEG C for 3-5 days; after the completion of the fermentation, the fermented mixture is dried, the dried mixture is crushed, and the crushed mixture is sieved to obtain the fermented Chinese herbal medicine preparation replacing antibiotics. The preparation can dispel coldness and wetness, promote salivation and moistening lungs, tonify and activate blood, clear heat and remove toxins, improve the symptoms of diarrhea, cough, swollen feet, convulsions, etc. of pigs in conservation stages, improve feed intake of the piglets, and improve skin color of the piglets, and the livestock and poultry Chinese herbal medicine additives taste good after being fermented and are less in addition amount.

Description

A kind of fermentation of Chinese herbal medicine preparation of alternative antibiotic and its preparation method and application

Technical field

The invention belongs to poultry Chinese herbal medicine additive field, in the fermentation particularly to a kind of alternative antibioticHerbal medicinal product and its preparation method and application.

Background technology

Nineteen twenty-nine Britain's bacteriologist Fleming is found that penicillin, and after 10 years, it obtains in World War IITo paying attention to and exploitation, and save the thousands of life by death threats.Huge to human society of antibioticBig impact the most just thus opens, hereafter, and the exploitation of antibiotic product and the important class of use Cheng Liao the world of medicineTopic.20th century four the fifties, American-European cultivation dealer finds that antibiotic fermentation residue adds the feedstuff length to pigSpeed and premunition have good improvement result.Then, from the fifties, use is gradually raised by American-European aquacultureLegalizing with antibiotic, this trend is the most quickly generalized to countries in the world.

The extensive application of antibiotic, brings the biggest benefit to raiser.But As time goes on, also carryA lot of puzzlements.Long-term interpolation can cause antibiotic residual in animal products and drug resistance, makes ill dynamicThing is difficult to treat.And the medicine of residual in animal, potential hazard can be brought to human health.Therefore, manyCountry promulgates a decree in succession, is prevented or restricted from antibiotic successively and applies in feedstuff.Seek new additive portionDivide or the use of replacing whole antibiotic has become focus.

Chinese herbal medicine environmental protection, safe and reliable, have medicinal and nutrition double effects concurrently, pre-in Swine ProductionAnti-property is rationally added, and can play the health-care effects such as reduction pig prevalence, growth promotion, increasing breeding, support in ecologyApplication prospect in growing is boundless.Research confirms, Chinese medicine additive can improve Small Intestine of Piglets mucosal epitheliumEndolymph cell and goblet cell quantity, improve the Intestinal Mucosal Immunity function of body, effectively alleviates piglet and breaksMilk stress wait.But traditional Chinese herbal medicine additive exists, and addition is big, increase cost, and it is agreeable to the taste to affect feedstuffThe shortcomings such as property.Microorganism has very abundant enzyme system, has powerful decomposition, the ability of transformation substance.Utilize microorganism that Chinese herbal medicine is fermented so that Chinese herbal medicine and probiotic bacteria realize organic assembling, not only improveChinese herbal medicine pharmacologically active, improve its using effect, probiotic bacteria more can be effectively improved the intestinal health of pig,Regulation metabolic function.

Summary of the invention

In place of solving above-mentioned the deficiencies in the prior art, the primary and foremost purpose of the present invention is to provide onePlant the fermentation of Chinese herbal medicine preparation of alternative antibiotic.

A further object of the present invention is to provide the preparation side of the fermentation of Chinese herbal medicine preparation of above-mentioned alternative antibioticMethod.

It is an object of the invention to provide the application of the fermentation of Chinese herbal medicine preparation of above-mentioned alternative antibiotic.

The purpose of the present invention is achieved through the following technical solutions:

The fermentation of Chinese herbal medicine preparation of a kind of alternative antibiotic, said preparation is fermented as raw material by following medical materialIt is prepared from: Rhizoma Zingiberis Recens 2～4 mass parts, Radix Glycyrrhizae 5～7 mass parts, Fructus Mume 8～10 mass parts, Ramulus Cinnamomi 9～11Mass parts, the Radix Paeoniae Alba 9～11 mass parts, Flos Lonicerae 9～11 mass parts, the Rhizoma Atractylodis Macrocephalae 9～11 mass parts, Cortex Magnoliae Officinalis 9～11Mass parts, mass parts Radix Ophiopogonis 13～17, Semen sojae atricolor 27～33 mass parts, silkworm excrement 27～33 mass parts.

Above-mentioned preparation is preferably prepared from as raw material is fermented by following medical material: Rhizoma Zingiberis Recens 3 mass parts, Radix Glycyrrhizae 6Mass parts, Fructus Mume 9 mass parts, Ramulus Cinnamomi 10 mass parts, the Radix Paeoniae Alba 10 mass parts, Flos Lonicerae 10 mass parts, the Rhizoma Atractylodis Macrocephalae10 mass parts, Cortex Magnoliae Officinalis 10 mass parts, mass parts Radix Ophiopogonis 15, Semen sojae atricolor 30 mass parts, silkworm excrement 30 mass parts.

The preparation method of the fermentation of Chinese herbal medicine preparation of above-mentioned a kind of alternative antibiotic, including following operation stepRapid:

(1) weigh Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Fructus Mume, Ramulus Cinnamomi, the Radix Paeoniae Alba, Flos Lonicerae, the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis, Radix Ophiopogonis,Semen sojae atricolor, silkworm excrement, pulverize and sieve after mixing, with the ethanol uniform sterilization of spraying that concentration expressed in percentage by volume is 75%40min, through 55 DEG C of drying, obtains Chinese herbal medicine powder；

(2) ratio that step (1) gained Chinese herbal medicine powder and zymocyte liquid are 100:2 in mass ratio is mixed,Bacterium Chinese herbal medicine powder must be contained；By the ratio mixing containing bacterium Chinese herbal medicine powder with fermentation medium 50:3 in mass ratio, then pressSolid-to-liquid ratio 1:1 adds sterilized water, ferments 3～5 days under the conditions of 26 DEG C, and bottom ventilation, ventilation is0.2m³·min^-1·m^-3, draft type stops 30min for logical 30min；In described zymocyte liquid, total bacteria count is 10⁷~10⁸CFU/mL, wherein contains mass ratio for (1～5): (3～7): the Bacillus licheniformis of (2～6),Bacillus subtilis and bacillus acidophilus；Described fermentation medium comprises following component: glucose 3 parts, peptone3 parts, 0.1 part of sodium chloride, manganese sulfate 0.1 part, 0.1 part of magnesium sulfate；

(3) with 55 DEG C of forced air dryings after fermentation ends so that it is moisture is less than mass percent 10%, pulverizes60 mesh sieves, obtain the fermentation of Chinese herbal medicine preparation of alternative antibiotic.

Sieving described in step (1) was 30 mesh sieves.

The application in preparing piglet cradling material of the fermentation of Chinese herbal medicine preparation of above-mentioned alternative antibiotic.

The fermentation of Chinese herbal medicine preparation of above-mentioned alternative antibiotic addition in piglet cradling material is mass fraction0.2%.

The principle of the present invention is:

Rhizoma Zingiberis Recens slightly warm in nature, pungent, return lung, spleen, stomach warp, relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing；WithIn anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.

Radix Glycyrrhizae property is sweet, flat；Enter spleen, stomach, lung meridian；Heat-clearing and toxic substances removing, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription；Cure mainlyLaryngopharynx swelling and pain, cough, weakness of the spleen and stomach, taste-blindness rate, hepatitis, hysteria, carbuncle furuncle and phyma poison, medicineThing and alimentary toxicosis, be a kind of tonification Chinese herbal medicine.

Fructus Mume sour in the mouth, puckery, property is put down, and returns liver, spleen, lung, large intestine channel, can astringe the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, peaceAscarid, for chronic cough of deficiency lung, chronic diarrhea chronic dysentery, deficiency-heat quenches one's thirst, ascariasis of biliary tract vomiting stomachache.

Ramulus Cinnamomi nature and flavor acrid, sweet, warm, enter lung, the heart, bladder warp, are to cure mainly the drugs for dispelling internal cold that interior cold is conventional, toolThere are complement sun, promoting blood circulation, effect of warming the spleen and stomach, energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, cold expellingPain relieving.

Radix Paeoniae Alba property picric acid is slightly cold, and enters Liver Channel, and nourish blood yin fluid astringing, easing the affected liver to relieve pain, and suppressing liver-YANG withers for blood deficiencyYellow, menses is uncomfortable, dysmenorrhea, metrorrhagia, disharmony of nutrient QI with defensive QI, aversion to wind spontaneous perspiration, hypochondriac pain due to stagnation of liverQI, stomachache, extremity contractionThe diseases such as pain and dizziness due to hyperactivity of liver-YANG headache.

Flos Lonicerae property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil；Flos Lonicerae is certainlyGu is described as the good medicine of heat-clearing and toxic substances removing；Flos Lonicerae can dispelling wind-heat, be also apt to heat-clearing and toxic substances removing, for various heatSexually transmitted disease (STD), equal effect is notable.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, for spleenEmpty lack of appetite, abdominal distention has loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration.

Cortex Magnoliae Officinalis bitter in the mouth, pungent, warm in nature, return spleen, stomach, large intestine channel, can circulation of qi promoting removing food stagnancy, dampness except full, sending down the abnormal ascending QIRelievining asthma, cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, the vomiting and diarrhoea of gastral cavity painful abdominal mass, expectorant heap soil or fertilizer over and around the roots QI rising in reverse order, fullness in the chest is breathed with cough.

Radix Ophiopogonis sweet in the mouth, micro-hardship, cold nature, return stomach, lung, heart channel, have nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clearEffect of heart relieving restlessness, cough for dryness of the lung dry cough, deficiency of YIN consumptive disease, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst,The diseases such as vexed insomnia, dryness of the intestine constipation, can enter stomach with nourishing the stomach liquid, stimulating appetite, more can enter spleen to help spleen to dissipate essenceIn lung, Dingchuan relieving coughing.

Semen sojae atricolor is put down, sweet in the mouth, has heat clearing away of inducing sweat, the suppressing the hyperactive liver that nourishes blood, Bu Shen Zhuang the moon, effect of qi-restoratives hair color,It is many that Semen sojae atricolor enters kidney merit, thus can harness the river, relieving distension, the therapeutic method to keep the adverse QI flowing downwards, control wind heat and promoting blood circulation and detoxication, all alimentary toxicosis or medicineThing is poisoned, and all can use decoction of black soybean and Radix Glycyrrhizae to decoct soup and drinks, and is used for detoxifying.

Silkworm excrement is sweet in flavor and warm in property, enters liver, spleen, stomach warp, have dampness, dispel the wind, regulating the function of the stomach to resolve the turbidity, invigorate blood circulation analgesic therapy itMerit；It is usually used in the diseases such as rheumatic arthralgia, wind syndrome of head, headache, skin pruritus, waist-leg cold type of pain, stomachache vomiting and diarrhoea.

The preparation of inventive formulation combines the physiological characteristics of nursery pig.Nursery pig stage piglet has just left sow,The intestines and stomach and immune system are not perfect, the cold in winter and the flushing of column home in summer, the most easily make cold-damp invade body andCausing the symptoms such as baby pig diarrhea, cough, swelling of the feet, tic, we comprise the multi-flavors such as Rhizoma Zingiberis Recens, Ramulus Cinnamomi, silkworm excrementInduce sweat the evil medical material of warming middle-JIAO, damp eliminating, with the symptom such as reduce that nursery pig is had loose bowels；Fructus Mume, promoting the production of body fluid for nourishing the lung Radix Ophiopogonis,Reduce chronic cough symptom；Coordinate the multi-flavor nourishing the stomach appetizing medical materials such as Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Cortex Magnoliae Officinalis to improve piglet the intestines and stomach simultaneouslyHealth, improves piglet feed intake；The Radix Paeoniae Alba, Semen sojae atricolor, silkworm excrement etc. have effects such as nourishing blood, invigorate blood circulation, furtherImprove piglet health degree, improve the piglet colour of skin；Radix Glycyrrhizae, Flos Lonicerae, Semen sojae atricolor etc. have again or heat clearing away or solutionPoison effect, above temperature constipation due to pathogenic cold closes, and negative and positive are coordinated.And by fermentation after can improve medical material utilization rate, reduce addDosage, improves mouthfeel simultaneously.

The present invention by the research to nursery pig physiological characteristics, Rational choice Chinese herbal medicine formula, and by micro-lifeThing fermentation process, produces a kind of green additive with substitute antibiotics, its to piglet enhancing immunity, subtractHave loose bowels less, promote that growth plays an important role.

Hinge structure of the present invention, has such advantages as and beneficial effect: the present invention can dispelling cold and dampness, lifeTianjin lung moistening, nourshing blood and promoting blood circulation, heat-clearing and toxic substances removing, improve child care stage pig have loose bowels, cough, swelling of the feet, tic etc.Symptom, improves piglet feed intake, and can improve the piglet colour of skin, and after fermentation, mouthfeel is suitable, addition is few,The fermentation of Chinese herbal medicine preparation of alternative antibiotic is to promoting that cultivation safety and food safety have very important meaningJustice, has the biggest application prospect.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention do not limitIn this.

Embodiment 1

(1) Rhizoma Zingiberis Recens 3 mass parts, Radix Glycyrrhizae 6 mass parts, Fructus Mume 9 mass parts, Ramulus Cinnamomi 10 mass parts, white is weighedChinese herbaceous peony 10 mass parts, Flos Lonicerae 10 mass parts, the Rhizoma Atractylodis Macrocephalae 10 mass parts, Cortex Magnoliae Officinalis 10 mass parts, mass parts Radix Ophiopogonis 15,Semen sojae atricolor 30 mass parts, silkworm excrement 30 mass parts, pulverized 30 mesh sieves after mixing, is 75% by concentration expressed in percentage by volumeThe ethanol uniform sterilization 40min of spraying, through 55 DEG C of drying, obtains Chinese herbal medicine powder；

(2) ratio that step (1) gained Chinese herbal medicine powder and zymocyte liquid are 100:2 in mass ratio is mixed,Bacterium Chinese herbal medicine powder must be contained；By the ratio mixing containing bacterium Chinese herbal medicine powder with fermentation medium 50:3 in mass ratio, then pressSolid-to-liquid ratio 1:1 adds sterilized water, ferments 4 days under the conditions of 26 DEG C, bottom ventilation；Total bacterium in described zymocyte liquidNumber is 10⁷～10⁸CFU/mL, wherein containing mass ratio is the Bacillus licheniformis of 1:3:2, bacillus subtilisAnd bacillus acidophilus；Described fermentation medium comprises following component: glucose 3 mass parts, peptone 3 massPart, sodium chloride 0.1 mass parts, manganese sulfate 0.1 mass parts, magnesium sulfate 0.1 mass parts；

(3) with 55 DEG C of forced air dryings after fermentation ends so that it is moisture is less than mass percent 10%, pulverizes60 mesh sieves, obtain the fermentation of Chinese herbal medicine preparation of alternative antibiotic.

Embodiment 2

(1) Rhizoma Zingiberis Recens 2 mass parts, Radix Glycyrrhizae 5 mass parts, Fructus Mume 8 mass parts, Ramulus Cinnamomi 9 mass parts, the Radix Paeoniae Alba are weighed9 mass parts, Flos Lonicerae 9 mass parts, the Rhizoma Atractylodis Macrocephalae 9 mass parts, Cortex Magnoliae Officinalis 9 mass parts, mass parts Radix Ophiopogonis 13, Semen sojae atricolor27 mass parts, silkworm excrement 27 mass parts, pulverized 30 mesh sieves after mixing, is the ethanol of 75% by concentration expressed in percentage by volumeSpray uniform sterilization 40min, through 55 DEG C of drying, obtains Chinese herbal medicine powder；

(2) ratio that step (1) gained Chinese herbal medicine powder and zymocyte liquid are 100:2 in mass ratio is mixed,Bacterium Chinese herbal medicine powder must be contained；By the ratio mixing containing bacterium Chinese herbal medicine powder with fermentation medium 50:3 in mass ratio, then pressSolid-to-liquid ratio 1:1 adds sterilized water, ferments 3 days under the conditions of 26 DEG C, bottom ventilation；Total bacterium in described zymocyte liquidNumber is 10⁷～10⁸CFU/mL, wherein containing mass ratio is the Bacillus licheniformis of 5:7:6, bacillus subtilisAnd bacillus acidophilus；Described fermentation medium comprises following component: glucose 3 mass parts, peptone 3 massPart, sodium chloride 0.1 mass parts, manganese sulfate 0.1 mass parts, magnesium sulfate 0.1 mass parts；

(3) with 55 DEG C of forced air dryings after fermentation ends so that it is moisture is less than mass percent 10%, pulverizes60 mesh sieves, obtain the fermentation of Chinese herbal medicine preparation of alternative antibiotic.

Embodiment 3

(1) Rhizoma Zingiberis Recens 4 mass parts, Radix Glycyrrhizae 7 mass parts, Fructus Mume 10 mass parts, Ramulus Cinnamomi 11 mass parts, white is weighedChinese herbaceous peony 11 mass parts, Flos Lonicerae 11 mass parts, the Rhizoma Atractylodis Macrocephalae 11 mass parts, Cortex Magnoliae Officinalis 11 mass parts, mass parts Radix Ophiopogonis 17,Semen sojae atricolor 33 mass parts, silkworm excrement 33 mass parts, pulverized 30 mesh sieves after mixing, is 75% by concentration expressed in percentage by volumeThe ethanol uniform sterilization 40min of spraying, through 55 DEG C of drying, obtains Chinese herbal medicine powder；

(2) ratio that step (1) gained Chinese herbal medicine powder and zymocyte liquid are 100:2 in mass ratio is mixed,Bacterium Chinese herbal medicine powder must be contained；By the ratio mixing containing bacterium Chinese herbal medicine powder with fermentation medium 50:3 in mass ratio, then pressSolid-to-liquid ratio 1:1 adds sterilized water, ferments 4 days under the conditions of 26 DEG C, bottom ventilation；Total bacterium in described zymocyte liquidNumber is 10⁷～10⁸CFU/mL, wherein containing mass ratio is the Bacillus licheniformis of 2:5:5, bacillus subtilisAnd bacillus acidophilus；Described fermentation medium comprises following component: glucose 3 mass parts, peptone 3 massPart, sodium chloride 0.1 mass parts, manganese sulfate 0.1 mass parts, magnesium sulfate 0.1 mass parts；

(3) with 55 DEG C of forced air dryings after fermentation ends so that it is moisture is less than mass percent 10%, pulverizes60 mesh sieves, obtain the fermentation of Chinese herbal medicine preparation of alternative antibiotic.

Embodiment 4

(1) Rhizoma Zingiberis Recens 3 mass parts, Radix Glycyrrhizae 6 mass parts, Fructus Mume 8 mass parts, Ramulus Cinnamomi 11 mass parts, white is weighedChinese herbaceous peony 9 mass parts, Flos Lonicerae 11 mass parts, the Rhizoma Atractylodis Macrocephalae 9 mass parts, Cortex Magnoliae Officinalis 11 mass parts, mass parts Radix Ophiopogonis 16,Semen sojae atricolor 28 mass parts, silkworm excrement 31 mass parts, pulverized 30 mesh sieves after mixing, is 75% by concentration expressed in percentage by volumeThe ethanol uniform sterilization 40min of spraying, through 55 DEG C of drying, obtains Chinese herbal medicine powder；

(2) ratio that step (1) gained Chinese herbal medicine powder and zymocyte liquid are 100:2 in mass ratio is mixed,Bacterium Chinese herbal medicine powder must be contained；By the ratio mixing containing bacterium Chinese herbal medicine powder with fermentation medium 50:3 in mass ratio, then pressSolid-to-liquid ratio 1:1 adds sterilized water, ferments 5 days under the conditions of 26 DEG C, bottom ventilation；Total bacterium in described zymocyte liquidNumber is 10⁷～10⁸CFU/mL, wherein containing mass ratio is the Bacillus licheniformis of 3:6:4, bacillus subtilisAnd bacillus acidophilus；Described fermentation medium comprises following component: glucose 3 mass parts, peptone 3 massPart, sodium chloride 0.1 mass parts, manganese sulfate 0.1 mass parts, magnesium sulfate 0.1 mass parts；

(3) with 55 DEG C of forced air dryings after fermentation ends so that it is moisture is less than mass percent 10%, pulverizes60 mesh sieves, obtain the fermentation of Chinese herbal medicine preparation of alternative antibiotic.

Embodiment 5

The ablactational baby pig of 150 9kg weights is chosen in test, is randomly divided into 3 groups, respectively A blank group, BAntibiotic group, C Chinese herbal medicine group, often 5 repetitions of group, 10 piglets of each repetition, A group is without antibiosisThe basal diet group of the medicines such as element and Chinese herbal medicine, B group adds 1.5g bacitracin zinc on the basis of basal diet+ 0.3g colistin/ton, C group adds the embodiment 1 of mass percent 0.2% on the basis of basal dietGained fermentation of Chinese herbal medicine preparation, 3 weeks+2 days experimental period, result of the test is as shown in table 1 below:

Table 1 fermentation of Chinese herbal medicine preparation performance detection result of the test

As can be seen from the above table, feedstuff-meat ratio and the diarrhea rate of Chinese herbal medicine group are minimum, and are substantially less than blank group,Illustrate that the Chinese herbal medicine of the interpolation present invention can improve food conversion ratio and improve the resistance of piglet；Additionally pigletLast counterpoise and Average weight increasing a day Chinese herbal medicine group also above other two groups, illustrate that thing of the present invention can promote weight gain of piglets.Chinese herbal medicine group piglet fur is substantially better than other two groups, illustrates that this invention has the effect improving the piglet colour of skin.

Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-mentioned realityExecute the restriction of example, the change made under other any spirit without departing from the present invention and principle, modification,Substitute, combine, simplify, all should be the substitute mode of equivalence, within being included in protection scope of the present invention.

Claims (6)

1. the fermentation of Chinese herbal medicine preparation of an alternative antibiotic, it is characterised in that: said preparation is by following medical materialIt is prepared from as raw material is fermented: Rhizoma Zingiberis Recens 2～4 mass parts, Radix Glycyrrhizae 5～7 mass parts, Fructus Mume 8～10 massPart, Ramulus Cinnamomi 9～11 mass parts, the Radix Paeoniae Alba 9～11 mass parts, Flos Lonicerae 9～11 mass parts, the Rhizoma Atractylodis Macrocephalae 9～11 massPart, Cortex Magnoliae Officinalis 9～11 mass parts, mass parts Radix Ophiopogonis 13～17, Semen sojae atricolor 27～33 mass parts, silkworm excrement 27～33 matterAmount part.

The fermentation of Chinese herbal medicine preparation of a kind of alternative antibiotic the most according to claim 1, its feature existsIn: said preparation is prepared from as raw material is fermented by following medical material: Rhizoma Zingiberis Recens 3 mass parts, Radix Glycyrrhizae 6 mass parts,Fructus Mume 9 mass parts, Ramulus Cinnamomi 10 mass parts, the Radix Paeoniae Alba 10 mass parts, Flos Lonicerae 10 mass parts, the Rhizoma Atractylodis Macrocephalae 10 mass parts,Cortex Magnoliae Officinalis 10 mass parts, mass parts Radix Ophiopogonis 15, Semen sojae atricolor 30 mass parts, silkworm excrement 30 mass parts.

The preparation side of the fermentation of Chinese herbal medicine preparation of a kind of alternative antibiotic the most according to claim 1 and 2Method, it is characterised in that include following operating procedure:

(1) weigh Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Fructus Mume, Ramulus Cinnamomi, the Radix Paeoniae Alba, Flos Lonicerae, the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis, Radix Ophiopogonis,Semen sojae atricolor, silkworm excrement, pulverize and sieve after mixing, with the ethanol uniform sterilization of spraying that concentration expressed in percentage by volume is 75%40min, through 55 DEG C of drying, obtains Chinese herbal medicine powder；

(2) ratio that step (1) gained Chinese herbal medicine powder and zymocyte liquid are 100:2 in mass ratio is mixed,Bacterium Chinese herbal medicine powder must be contained；By the ratio mixing containing bacterium Chinese herbal medicine powder with fermentation medium 50:3 in mass ratio, then pressSolid-to-liquid ratio 1:1 adds sterilized water, ferments 3～5 days under the conditions of 26 DEG C, bottom ventilation；In described zymocyte liquidTotal bacteria count is 10⁷～10⁸CFU/mL, wherein contains mass ratio for (1～5): (3～7): the ground of (2～6)Clothing bacillus cereus, bacillus subtilis and bacillus acidophilus；Described fermentation medium comprises following component: Fructus Vitis viniferaeSugar 3 parts, peptone 3 parts, 0.1 part of sodium chloride, manganese sulfate 0.1 part, 0.1 part of magnesium sulfate；

(3) with 55 DEG C of forced air dryings after fermentation ends so that it is moisture is less than mass percent 10%, pulverizes60 mesh sieves, obtain the fermentation of Chinese herbal medicine preparation of alternative antibiotic.

Preparation method the most according to claim 3, it is characterised in that: sieving described in step (1) was30 mesh sieves.

The fermentation of Chinese herbal medicine preparation of alternative antibiotic the most according to claim 1 and 2 is preparation pigletApplication in child care material.

Application the most according to claim 5, it is characterised in that: in the fermentation of described alternative antibioticHerbal medicinal product addition in piglet cradling material is mass fraction 0.2%.