Summary of the invention
For the problems referred to above, it is an object of the invention to provide a kind of volume little, radiate little, renal artery can be propped up simultaneouslyVelocity of blood flow monitoring device based on renal artery stent that frame blood vessel flow velocity is monitored in real time and method thereof.
For achieving the above object, the present invention takes techniques below scheme: a kind of velocity of blood flow based on renal artery stent is supervisedSurvey device, it is characterised in that this monitoring device includes a renal artery stent, two integrated circuits and an external processing apparatus；
Described renal artery stent uses as antenna, and integrated circuit described in two is respectively fixedly disposed at described renal artery stentBlood vessel entrance and exit at；Each described integrated circuit all include an energy supply module, one flow sensor,One memorizer, a data processor and one first radio-frequency (RF) receiving and transmission module, each described energy supply module is for for describedIntegrated circuit；The velocity of blood flow signal detected is transmitted to described number by described flow sensor through described memorizerAccording to processor, velocity of blood flow signal is converted into digital signal by described data processor, and is received by described first radio frequencySend out module and digital signal is transferred to described external processing apparatus through described renal artery stent.
Further, described external processing apparatus include a transmitting antenna, a reception antenna, one second radio-frequency (RF) receiving and transmission module,One processor, a transport module and a work station, by described second radio-frequency (RF) receiving and transmission module in described transmitting sky alignment bodyDescribed integrated circuit launch electromagnetic transmission energy, the described integrated electricity simultaneously and in described reception antenna receiving bodyRoad is sent to external velocity of blood flow signal, described second radio-frequency (RF) receiving and transmission module by the velocity of blood flow signal that receives through describedProcessor and transport module send to described work station.
Further, described renal artery stent includes plural bracing structure and some longitudinal support structure, oftenBracing structure described in one is bent to form ring support by a tinsel, passes through described in adjacent two between ring supportSome described longitudinal support structure being crisscross arranged are fixing to be connected, and forms network structure after making support strut, and described kidney movesPulsation frame is configured to by two isometric joints, and the one end often saving described support is all connected with ic output described in,The other end often saving described support is respectively arranged with insulant.
Further, described ring support uses sinusoidal configuration or sawtooth waveforms structure.
Further, described renal artery stent is set to as resonant frequency f of antenna:
In formula, N be the quantity of ring support, n be the fluctuating quantity of waveform in ring support, l be the length of longitudinal support structureDegree, C1、C2And C3It is positive coefficient.
Further, integrated circuit described in two is arranged on a string configuration, and strip integrated circuit moves along described kidneyPulsation frame is axial arranged.
Further, each described integrated circuit all uses segmentation structure, and stagewise integrated circuit is along renal artery stent axleTo layout.
Further, each described integrated circuit all uses square structure, is wrapped in its outside biological compatibility shellUse circular configuration.
Further, each described integrated circuit all uses loop configuration, annular integrated circuit place plane to move with described kidneyThe tangent plane of pulsation frame is parallel.
A kind of monitoring method based on described velocity of blood flow monitoring device, it is characterised in that include herein below: 1) setPut one and include flow sensor, data processor, the first radio-frequency (RF) receiving and transmission module and the velocity of blood flow of external processing apparatusMonitoring device, wherein, external processing apparatus includes reception antenna, the second radio-frequency (RF) receiving and transmission module, processor, transmission mouldBlock and work station；2) two flow sensors gather the velocity of blood flow signal at renal artery stent blood vessel two ends respectively, and pointTransmitting to the first radio-frequency (RF) receiving and transmission module after not processed by corresponding data processor, two first radio-frequency (RF) receiving and transmission module are to receptionVelocity of blood flow signal be modulated respectively after be sent to external processing apparatus by antenna；3) reception antenna will receiveThe velocity of blood flow signal at renal artery stent blood vessel two ends after the second radio-frequency (RF) receiving and transmission module is demodulated and at treated deviceWork station it is sent to after reason.
Due to the fact that and take above technical scheme, it has the advantage that 1, the present invention includes a renal artery stent,Two integrated circuits and an external processing apparatus, two integrated circuits be respectively fixedly disposed at renal artery stent blood vessel entrance andRenal artery stent velocity of blood flow is monitored by exit in real time, it is possible to obtain velocity of blood flow situation in renal artery stent,Effectively the duty of renal artery stent can be supervised by the velocity of blood flow difference at renal artery stent blood vessel two endsSurvey.2, due to the fact that the mode taking to detect in real time, patient can understand own health shape without going to hospital to do radiographyCondition, reduces cost and risk, decreases the misery of patient, makes the feedback that doctor obtains more quickly effectively.3, originallyInvention can implant integrated circuit while operative treatment implants support, it is to avoid the misery of patient's second operation.ThisIn the bright status monitoring that can be widely applied to renal artery disease.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is carried out detailed description.It should be appreciated, however, that being provided only more of accompanying drawingUnderstanding the present invention well, they should not be interpreted as limitation of the present invention.
As it is shown in figure 1, the velocity of blood flow monitoring device based on renal artery stent of the present invention, including a renal artery stent,Two integrated circuits and an external processing apparatus；Renal artery stent is used for carrying out energy and signal transmission, two collection as antennaBecoming circuit to be respectively fixedly disposed at the entrance and exit of renal artery stent blood vessel, each integrated circuit all includes an energySupply module, one flow sensor, a memorizer, a data processor and one first radio-frequency (RF) receiving and transmission module.Each energyAmount supply module is through being radiated by external processing apparatus by the first radio-frequency (RF) receiving and transmission module reception as the renal artery stent of antennaTo internal electromagnetic wave, it is that on integrated circuit, miscellaneous part is powered by the way of radio frequency energy is collected.Flow velocity passesVelocity of blood flow is believed by sensor by the velocity of blood flow signal stored device transmission detected to data processor, data processorNumber it is converted into digital signal, and loads the information such as integrated circuit ID, timestamp, by the first radio-frequency (RF) receiving and transmission module by numberWord signal to external processing apparatus, completes DATA REASONING, signal emission function through the antenna transmission as renal artery stent.Wherein, energy supply module can also use minicell, in order to directly powers for each parts on integrated circuit.
In a preferred embodiment, as in figure 2 it is shown, it is that NORDIC company produces that data processor can useNRF51822 chip.This chip ADC switched pins J6 is connected in parallel two flow sensors, and VDD power pins J1 is evenConnecing energy supply module, XC1, XC2 pin J37-J38 connects clock circuit, VDD_PA, ANT1, ANT2 pinJ30-J32 connects the first radio-frequency (RF) receiving and transmission module, and P0.01 pin J5 connects power sense circuit, DEC1 pin J39 warp3rd electric capacity C3 ground connection；Ground connection after VSS pin J33, J34 parallel connection, connects energy after VSS pin J33, J34 parallel connectionAmount supply module, the 4th electric capacity C4 in parallel between AVDD pin with VSS pin.DEC2 pin J29 is through the tenthElectric capacity C10 and EXP_GND pin J49 be connected after ground connection；VSS pin J13 ground connection, SWCLK pin is through the 3rd resistanceR3 ground connection.
Wherein, clock circuit includes the first electric capacity C1, the second electric capacity C2 and crystal oscillator X1, and crystal oscillator X1 controls end pin 1Through the second electric capacity C2 ground connection, crystal oscillator X1 outfan pin 2 is through the first electric capacity C1 ground connection；Crystal oscillator X1 controls end pinThe 1 XC1 pin J37 being additionally coupled to NRF51822 chip, crystal oscillator X1 outfan pin 2 is additionally coupled to NRF51822The XC2 pin J38 of chip.
Power sense circuit includes the first resistance R1, the second resistance R2 and electric capacity C13, and the first resistance R1 mono-terminates heightLevel (i.e. energy supply module), the first resistance R1 other end is through the second resistance R2 ground connection；It is positioned at the second resistance R2It is connected to NRF51822 by wire between two ends shunt capacitance C13, and the first resistance R1 other end and the second resistance R2The P0.01 pin J5 of chip.
In a preferred embodiment, as it is shown on figure 3, external processing apparatus include launch antenna, reception antenna,Second radio-frequency (RF) receiving and transmission module, processor, transport module and work station.By the second radio-frequency (RF) receiving and transmission module emitted sky alignmentInternal integrated circuit launches electromagnetic transmission energy, simultaneously and the integrated circuit that is received in antenna receiving body is sent to bodyOuter velocity of blood flow signal；The treated device of velocity of blood flow signal received, transport module are sent by radio-frequency (RF) receiving and transmission moduleTo work station, in case follow-up use.Wherein, work station can use the mobile terminal such as smart mobile phone, intelligent watch.
In a preferred embodiment, being provided with signal processing system in work station, signal processing system is according to settingMeasure the velocity of blood flow signal difference obtained in time and judge whether the blood vessel being provided with renal artery stent occurs restenosis.If velocity of blood flow difference exceeds preset range within the setting time, then it is assumed that the blood vessel being provided with renal artery stent occursRestenosis, if within the setting time, velocity of blood flow difference is in preset range, then it is assumed that be provided with renal artery and prop upThere is not restenosis in the blood vessel of frame.
In a preferred embodiment, as shown in Figure 4, renal artery stent includes plural bracing structure1 and some longitudinal support structure 2, each bracing structure 1 is bent to form ring support by a tinsel；AdjacentConnect by some longitudinal support structure 2 being crisscross arranged are fixing between two ring supports, after making support strut, form netShape structure.Ring support can use sinusoidal configuration or sawtooth waveforms structure.Renal artery stent is by two isometric joint supportsConstituting, the one end often saving support is all connected with an ic output, two joints be configured to integrated circuit antennaThe two poles of the earth feed.Wherein, it is respectively arranged with insulant at the other end often saving support, is fixed by insulantThe steadiness of this joint supporting structure.In the present embodiment, when this renal artery stent is as antenna, its radiance is more preferable,Frequency band is wider.
Renal artery stent is set to as resonant frequency f of antenna:
In formula, N be the quantity of ring support, n be the fluctuating quantity of waveform in ring support, l be longitudinal support structureLength, C1、C2And C3It is positive coefficient.Wherein, N, n and l are the biggest, and resonant frequency is the least.During use, byIn not adjusting the size of renal artery stent, so by adjusting waveform in quantity N of ring support, ring supportLength l of fluctuating quantity n and longitudinal support structure adjusts the resonant frequency of antenna.
In a preferred embodiment, each integrated circuit external is enclosed with biological compatibility shell.Each integratedCircuit can be fixed on outside renal artery stent by a gim peg, and one end of gim peg is welded on the pad of integrated circuitOn, the other end links together with renal artery stent outer wall；Gim peg is exposed to biological compatibility enclosure, rawThing compatibility shell is avoided that the rejection producing human body.Preferably, biological compatibility shell has the most pliable and the toughestProperty, can bend.The material of biological compatibility shell preferably employs polydimethylsiloxane (PDMS).During making,Can integrated circuit be put in a mold, with polydimethylsiloxane be filled with encapsulation, gim peg is left outside thusPrepare band biological compatibility shell and the integrated circuit of gim peg.
In a preferred embodiment, could be covered with biology at the solder joint of gim peg and renal artery stent compatibleProperty medicine film.Owing to the welding of gim peg and renal artery stent may destroy the biological compatibility outside renal artery stentShell, covers one layer of medicine film at gim peg and renal artery stent weld, can prevent the rejection of human body from sending out furtherRaw.
In a preferred embodiment, each integrated circuit by flexible PCB and is formed on this flexible PCBThe each modular circuit chip being made up of wafer is made, to adapt to volumetric constraint, and can be with the change of renal artery stent shapeIt is curved, but its length is less than renal artery stent length, and in order to not block blood vessel, its sectional area is less than0.5mm×0.5mm。
In a preferred embodiment, two integrated circuits can be arranged on a string configuration, the integrated electricity of stripCurb renal artery stent is axial arranged；Each integrated circuit all can use segmentation structure, stagewise integrated circuit edgeRenal artery stent is axial arranged, and integrated circuit external is enclosed with biological compatibility shell；Each integrated circuit is the most permissibleUse square structure, be wrapped in its outside biological compatibility shell and use circular configuration；Each integrated circuitTo use loop configuration, annular integrated circuit place plane is parallel with the tangent plane of renal artery stent.
The velocity of blood flow monitoring device based on renal artery stent using the present invention is described in detail below by specific embodimentThe detailed process that the velocity of blood flow of patient is monitored:
1, two flow sensors gather the velocity of blood flow signal at renal artery stent blood vessel two ends respectively, and pass through phase respectivelyTransmit after answering data processor processes to the first radio-frequency (RF) receiving and transmission module, first radio-frequency (RF) receiving and transmission module velocity of blood flow to receivingSignal is sent to external processing apparatus by the renal artery stent as antenna after being modulated respectively.
2, reception antenna by the velocity of blood flow signal at renal artery stent blood vessel two ends that receives through the second radio-frequency (RF) receiving and transmission moduleIt is sent to work station after being demodulated and after the process of treated device.
In a particular embodiment, use the velocity of blood flow monitoring device based on renal artery stent of the present invention that renal artery is propped upFrame duty carries out the process detected:
The signal processing system being arranged in work station by receive renal artery stent blood vessel two ends velocity of blood flow difference withPreset value compares, if the velocity of blood flow difference at renal artery stent blood vessel two ends is in default model within the setting timeIn enclosing, determine that renal artery stent duty is good, it is believed that the blood vessel being provided with renal artery stent does not occur restenosisPhenomenon；If the velocity of blood flow difference at renal artery stent blood vessel two ends exceeds preset range within the setting time, determine kidneyArterial bracket duty occurs abnormal, it is believed that be provided with the blood vessel generation restenosis phenomenon of renal artery stent, it addition,Can further appreciate that kidney moves according to the velocity of blood flow signal difference at the renal artery stent blood vessel two ends obtained as reference valueThe working condition of pulsation frame.
The various embodiments described above are merely to illustrate the present invention, and the structure of the most each parts, connected mode and processing technology etc. are allCan be varied from, every equivalents carried out on the basis of technical solution of the present invention and improvement, the most should notGet rid of outside protection scope of the present invention.