CN105832311A - Coronary stent based hemorheological monitoring device and coronary stent based hemorheological monitoring method - Google Patents

Abstract

The invention relates to a coronary stent based hemorheological monitoring device and a coronary stent based hemorheological monitoring method. The device is characterized by comprising a coronary stent, an integrated circuit and external processing equipment; the coronary stent serves as an antenna, and the integrated circuit is fixed to a blood vessel of the coronary stent; the integrated circuit comprises an energy supply module, a hemorheological detection module, a memory, a data processor and a first radio-frequency transceiving module, and the energy supply module is used for supplying power to the integrated circuit; the hemorheological detection module transmits detected hemorheological signals to the data processor through the memory, and then the data processor converts the hemorheological signals into digital signals and transmits the digital signals to the external processing equipment through the coronary stent by the aid of the first radio-frequency transceiving module.

Description

Hemorheology monitoring device based on heart coronary artery support and method thereof

Technical field

The present invention is about a kind of hemorheology monitoring device based on heart coronary artery support and method thereof, relates to doctorTreat monitoring technical field.

Background technology

Society, the quickening of rhythm of life and unscientific dietary habit, the factor such as shortage of self health consciousness,Causing cardiovascular disease incidence rate more and more higher, the whole world is died from the number of cardiovascular disease every year and is up to 15,000,000 people,Occupy the various cause of the death the first.At present, China's cardiovascular patient alreadys more than 2.7 hundred million people, and China dies from painstaking effort every yearNearly 3,000,000 people of pipe disease, account for the 51% of China's total Death causes every year, and with aged tendency of population trend, cardiovascularPrevalence is also in persistently rising.

Cardiovascular disease has the feature of " sickness rate is high, mortality rate is high, relapse rate is high, and complication is many ", coronary heart diseaseBeing one in cardiovascular disease more typically, it is supplied with the blood vessel of cardiotrophin material--and there is serious medicated porridge in coronary arterySample hardening or spasm, make coronary stricture or obstruction, forms thrombosis, causes obliteration, causes myocardial ischemia to lackOxygen or a kind of heart disease of infraction, also known as ischemic heart desease, mainly show as angina pectoris or myocardial infarction.The therapeutic modality of coronary heart disease is generally divided into Drug therapy, surgical operation and interventional therapy three major types.Though Drug therapy has allMany advantages, but cycle length, take effect slow, side effect big, conventional medicine is difficult to eliminate a large amount of of Wall of Artery accumulationLipid speckle is so that unobstructed blood vessel.Heart coronary artery support is most important part in coronary heart disease operation, and heart is preced withAfter the intervention operation of shape arterial bracket completes, need periodically to check.At present, heart coronary artery support is usually solelyVertical intervention, it no longer adds any other parts.

Summary of the invention

For the problems referred to above, it is an object of the invention to provide a kind of volume little, radiate little, simultaneously can be to heart coronariesHemorheology monitoring device based on heart coronary artery support that arterial bracket blood vessel rheology is monitored in real time andIts method.

For achieving the above object, the present invention takes techniques below scheme: a kind of blood based on heart coronary artery supportRheology monitoring device, it is characterised in that this monitoring device includes a heart coronary stent, an integrated circuit andExternal processing apparatus；Described heart coronary artery support uses as antenna, and described integrated circuit is fixedly installed on describedThe Ink vessel transfusing of heart coronary artery support；Described integrated circuit include energy supply module, hemorheology detection module,Memorizer, data processor and the first radio-frequency (RF) receiving and transmission module, described energy supply module is for supplying for described integrated circuitElectricity；The hemorheology signal detected is transmitted to described data by described hemorheology detection module through described memorizerReason device, hemorheology signal is converted into digital signal by described data processor, and by described first radio-frequency receiving-transmitting mouldDigital signal is transferred to described external processing apparatus through described heart coronary artery support by block.

Further, described external processing apparatus includes launching antenna, reception antenna, the second radio-frequency (RF) receiving and transmission module, processDevice, transport module and work station, by described integrated in described transmitting sky alignment body of described second radio-frequency (RF) receiving and transmission moduleCircuit transmission electromagnetic transmission energy, the described integrated circuit simultaneously and in described reception antenna receiving body is sent to externalHemorheology signal, described second radio-frequency (RF) receiving and transmission module by the hemorheology signal that receives through described processor and biographyDefeated module sends to described work station.

Further, described heart coronary artery support includes plural bracing structure and some longitudinal bracings knotStructure, each described bracing structure is bent to form ring support by a tinsel, ring support described in adjacent two itBetween connect by some described longitudinal support structure being crisscross arranged are fixing, form network structure, institute after making support strutState heart coronary artery support to be configured to by two isometric joints, often save one end all integrated electricity with described in of described supportRoad outfan connects, and the other end often saving described support is respectively arranged with insulant.

Further, described ring support uses sinusoidal configuration or sawtooth waveforms structure.

Further, described heart coronary artery support is set to as resonant frequency f of antenna:

$\frac{1}{f}=C_{1}N+C_{2}n+C_{3}l$

In formula, N be the quantity of ring support, n be the fluctuating quantity of waveform in ring support, l be the length of longitudinal support structureDegree, C₁、C₂And C₃It is positive coefficient.

Further, described integrated circuit uses string configuration, and strip integrated circuit props up along described heart coronary arteryFrame is axial arranged.

Further, described integrated circuit uses square structure, is wrapped in its outside biological compatibility shell and uses circleShape structure.

Further, described integrated circuit uses loop configuration, annular integrated circuit place plane to move with described heart coronariesThe tangent plane of pulsation frame is parallel.

A kind of monitoring method based on described hemorheology monitoring device, it is characterised in that include herein below: 1) setPut one and include hemorheology detection module, data processor, the first radio-frequency (RF) receiving and transmission module and the blood of external processing apparatusLiquid stream become monitoring device, wherein, external processing apparatus include reception antenna, the second radio-frequency (RF) receiving and transmission module, processor,Transport module and work station；2) hemorheology detection module gathers the hemorheology signal of heart coronary artery stented vessel,And by transmitting after data processor processes to the first radio-frequency (RF) receiving and transmission module, first radio-frequency (RF) receiving and transmission module blood to receivingRheology signal is sent to external processing apparatus by antenna after being modulated；3) heart coronaries that reception antenna will receiveArterial bracket endovascular hemorheology signal is sent out after the second radio-frequency (RF) receiving and transmission module is demodulated and after the process of treated deviceDeliver to work station.

Due to the fact that and take above technical scheme, it has the advantage that 1, the present invention includes that heart coronary artery props upFrame, integrated circuit and external processing apparatus, it is interior to heart that integrated circuit is fixedly installed on heart coronary artery stented vesselCoronary stent hemorheology is monitored in real time, it is possible to obtain hemorheology situation in heart coronary artery support,Can duty to heart coronary artery support effectively by the hemorheology signal in heart coronary artery supportIt is monitored.2, due to the fact that the mode taking to detect in real time, patient can understand self without going to hospital to do radiographyHealth status, reduces cost and risk, decreases the misery of patient, makes the feedback that doctor obtains more quickly effectively.3, the present invention can implant integrated circuit while operative treatment implants heart coronary artery support, it is to avoid patient's secondaryThe misery of operation.The present invention can be widely applied in the status monitoring of heart coronary artery disease.

Accompanying drawing explanation

Fig. 1 is the integrated circuit structure schematic diagram of the present invention；

Fig. 2 is the structural representation during data processor employing NRF51822 chip of the present invention；

Fig. 3 is the external processing apparatus structural representation of the present invention；

Fig. 4 is that heart coronary artery support of the present invention uses saw tooth wave shape structural representation.

Detailed description of the invention

Below in conjunction with accompanying drawing, the present invention is carried out detailed description.It should be appreciated, however, that being provided only more of accompanying drawingUnderstanding the present invention well, they should not be interpreted as limitation of the present invention.

As it is shown in figure 1, the hemorheology monitoring device based on heart coronary artery support of the present invention, including a heartCoronary stent, an integrated circuit and an external processing apparatus；Heart coronary artery support is used for carrying out as antennaEnergy and signal transmission, integrated circuit is fixedly installed in heart coronary artery support, and integrated circuit includes energy supplyModule, hemorheology detection module, memorizer, data processor and the first radio-frequency (RF) receiving and transmission module.Energy supply moduleThrough be radiated to by external processing apparatus by the first radio-frequency (RF) receiving and transmission module reception as the heart coronary artery support of antennaElectromagnetic wave, is that on integrated circuit, miscellaneous part is powered by less radio-frequency by being converted into electric energy after collection of energy.Blood streamBecoming detection module the hemorheology signal detected transmission to be stored to memorizer, data processor is read from memorizerFetch data, hemorheology signal is converted into digital signal, and loads the information such as integrated circuit ID, timestamp, pass throughFirst radio-frequency (RF) receiving and transmission module using digital signal through as the antenna transmission of heart coronary artery support to external processing apparatus,Completing DATA REASONING, signal emission function, wherein, energy supply module can also use minicell, in order to directlyPower for each parts on integrated circuit.It addition, hemorheology detection module includes whole blood viscosity detection, plasma viscosityThe detections such as detection, packed cell volume detection, erythrocyte sedimentation rate detection, erythrocyte electrophoretic time detection and platelet aggregation rate detectionOne or more in module, corresponding hemorheology signal include whole blood viscosity signal, plasma viscosity signal, red carefullyBorn of the same parents' hematocrit signal, erythrocyte sedimentation rate signal, erythrocyte electrophoretic time signal and platelet aggregation rate signal etc..

In a preferred embodiment, as in figure 2 it is shown, it is that NORDIC company produces that data processor can useNRF51822 chip.This chip ADC switched pins J6 connects hemorheology detection module, and VDD power pins J1 is evenConnecing energy supply module, XC1, XC2 pin J37-J38 connects clock circuit, VDD_PA, ANT1, ANT2 pinJ30-J32 connects the first radio-frequency (RF) receiving and transmission module, and P0.01 pin J5 connects power sense circuit, DEC1 pin J39 warp3rd electric capacity C3 ground connection；Ground connection after VSS pin J33, J34 parallel connection, connects energy after VSS pin J33, J34 parallel connectionAmount supply module, the 4th electric capacity C4 in parallel between AVDD pin with VSS pin.DEC2 pin J29 is through the tenthElectric capacity C10 and EXP_GND pin J49 be connected after ground connection；VSS pin J13 ground connection, SWCLK pin is through the 3rd resistanceR3 ground connection.

Wherein, clock circuit includes the first electric capacity C1, the second electric capacity C2 and crystal oscillator X1, and crystal oscillator X1 controls end pin 1Through the second electric capacity C2 ground connection, crystal oscillator X1 outfan pin 2 is through the first electric capacity C1 ground connection；Crystal oscillator X1 controls end pinThe 1 XC1 pin J37 being additionally coupled to NRF51822 chip, crystal oscillator X1 outfan pin 2 is additionally coupled to NRF51822The XC2 pin J38 of chip.

Power sense circuit includes the first resistance R1, the second resistance R2 and electric capacity C13, and the first resistance R1 mono-terminates heightLevel (i.e. energy supply module), the first resistance R1 other end is through the second resistance R2 ground connection；It is positioned at the second resistance R2It is connected to NRF51822 by wire between two ends shunt capacitance C13, and the first resistance R1 other end and the second resistance R2The P0.01 pin J5 of chip.

In a preferred embodiment, as it is shown on figure 3, external processing apparatus include launch antenna, reception antenna,Second radio-frequency (RF) receiving and transmission module, processor, transport module and work station.By the second radio-frequency (RF) receiving and transmission module emitted sky alignmentInternal integrated circuit launches electromagnetic transmission energy, simultaneously and the integrated circuit that is received in antenna receiving body is sent to bodyOuter hemorheology signal；Second radio-frequency (RF) receiving and transmission module is by the treated device of hemorheology signal received, transport moduleSend to work station, in case follow-up use.Wherein, work station can use smart mobile phone, intelligent watch etc. mobile eventuallyEnd.

In a preferred embodiment, being provided with signal processing system in work station, signal processing system is according to settingMeasure the hemorheology signal obtained in time and judge whether the blood vessel being provided with heart coronary artery support occurs restenosis,If within the setting time, hemorheology signal exceeds preset range, then it is assumed that be provided with the blood of heart coronary artery supportPipe generation restenosis, if within the time set, hemorheology signal is in preset range, then it is assumed that be provided withThere is not restenosis in the blood vessel of heart coronary artery support.

In a preferred embodiment, as shown in Figure 4, heart coronary artery support includes plural horizontalSupport structure 1 and some longitudinal support structure 2, each bracing structure 1 is bent to form annular by a tinselFrame；Connect by some longitudinal support structure 2 being crisscross arranged are fixing between adjacent two ring supports, make support strutRear formation network structure.Ring support can use sinusoidal configuration or sawtooth waveforms structure.Heart coronary artery support byTwo isometric joints are configured to, and the one end often saving support is all connected with ic output, two joints be configured to collectionThe two poles of the earth becoming circuit antenna feed.Wherein, it is respectively arranged with insulant at the other end often saving support, passes throughThe steadiness of this joint supporting structure fixed by insulant.In the present embodiment, this heart coronary artery support is as antennaTime, its radiance is more preferable, and frequency band is wider.

Heart coronary artery support is set to as resonant frequency f of antenna:

$\frac{1}{f}=C_{1}N+C_{2}n+C_{3}l$

In formula, N be the quantity of ring support, n be the fluctuating quantity of waveform in ring support, l be longitudinal support structureLength, C₁、C₂And C₃It is positive coefficient.Wherein, N, n and l are the biggest, and resonant frequency is the least.During use, byIn not adjusting the size of heart coronary artery support, so by adjusting in quantity N of ring support, ring supportFluctuating quantity n of waveform and length l of longitudinal support structure adjust the resonant frequency of antenna.

In a preferred embodiment, integrated circuit external is enclosed with biological compatibility shell.Integrated circuit is permissibleBeing fixed on heart coronary artery stent outer by a gim peg, one end of gim peg is welded on the pad of integrated circuit,The other end links together with heart coronary artery support outer wall；Gim peg is exposed to biological compatibility enclosure,Biological compatibility shell is avoided that the rejection producing human body.Preferably, biological compatibility shell has the most softToughness, can bend.The material of biological compatibility shell preferably employs polydimethylsiloxane (PDMS).During making,Can integrated circuit be put in a mold, with polydimethylsiloxane be filled with encapsulation, gim peg is left outside thusPrepare band biological compatibility shell and the integrated circuit of gim peg.

In a preferred embodiment, could be covered with biology at the solder joint of gim peg and heart coronary artery supportCompatibility medicine film.Owing to the welding of gim peg and heart coronary artery support may destroy heart coronary artery supportThe biological compatibility shell of outside, covers one layer of medicine film at gim peg and heart coronary artery support weld, can enterOne step prevents the rejection of human body from occurring.

In a preferred embodiment, integrated circuit by flexible PCB and is formed on this flexible PCB by waferThe each modular circuit chip made is made, to adapt to volumetric constraint, and can be with the change of heart coronary stent shapeIt is curved, but its length is less than heart coronary artery stent length, and in order to not block blood vessel, its sectional areaLess than 0.3mm × 0.1mm.

In a preferred embodiment, integrated circuit can use string configuration, and strip integrated circuit is along heartCoronary stent is axial arranged；Integrated circuit can use square structure, is wrapped in its outside biological compatibilityShell uses circular configuration；Integrated circuit can use loop configuration, annular integrated circuit place plane and heart coronariesThe tangent plane of arterial bracket is parallel.

Hemorheology based on the heart coronary artery support prison using the present invention is described in detail below by specific embodimentThe detailed process that the hemorheology of patient is monitored by survey device:

1, the collection of hemorheology detection module is provided with the endovascular hemorheology signal of heart coronary artery support, andBy transmitting after data processor processes to the first radio-frequency (RF) receiving and transmission module, first radio-frequency (RF) receiving and transmission module blood stream to receivingVarying signal is sent to external processing apparatus by the heart coronary artery support as antenna after being modulated.

2, reception antenna by the endovascular hemorheology signal being provided with heart coronary artery support that receives through secondIt is sent to work station after radio-frequency (RF) receiving and transmission module is demodulated and after the process of treated device.

In a particular embodiment, use the hemorheology monitoring device based on heart coronary artery support of the present invention to the heartDirty coronary stent duty carries out the process detected:

The vessel inner blood being provided with heart coronary artery support that the signal processing system being arranged in work station will receiveRheology signal compares with preset value, if the hemorheology letter of heart coronary stent blood vessel within the setting timeNumber in preset range, determine that the work of heart coronary artery support is in good condition, it is believed that heart coronary artery support is installedBlood vessel there is not restenosis phenomenon；If the endovascular hemorheology of heart coronary stent within the setting timeSignal exceeds preset range, determines that heart coronary artery support duty occurs abnormal, it is believed that be provided with heart coronariesThe blood vessel generation restenosis phenomenon of arterial bracket, furthermore it is possible to according in the heart coronary artery stented vessel obtainedHemorheology signal further appreciates that the working condition of heart coronary artery support as reference value.

The various embodiments described above are merely to illustrate the present invention, and the structure of the most each parts, connected mode and processing technology etc. are allCan be varied from, every equivalents carried out on the basis of technical solution of the present invention and improvement, the most should notGet rid of outside protection scope of the present invention.

Claims (9)

1. a hemorheology monitoring device based on heart coronary artery support, it is characterised in that this monitoring device bagInclude a heart coronary stent, an integrated circuit and an external processing apparatus；

Described heart coronary artery support uses as antenna, and described integrated circuit is fixedly installed on described heart coronaries and movesThe Ink vessel transfusing of pulsation frame；Described integrated circuit includes energy supply module, hemorheology detection module, memorizer, numberAccording to processor and the first radio-frequency (RF) receiving and transmission module, described energy supply module is used for as described integrated circuit；Described bloodLiquid stream becomes detection module to be transmitted the hemorheology signal detected to described data processor through described memorizer, describedHemorheology signal is converted into digital signal by data processor, and numeral is believed by described first radio-frequency (RF) receiving and transmission moduleNumber it is transferred to described external processing apparatus through described heart coronary artery support.

2. hemorheology monitoring device based on heart coronary artery support as claimed in claim 1, it is characterised in thatDescribed external processing apparatus includes launching antenna, reception antenna, the second radio-frequency (RF) receiving and transmission module, processor, transport moduleAnd work station, described second radio-frequency (RF) receiving and transmission module described integrated circuit in described transmitting sky alignment body launch electromagnetismRipple transmission energy, the described integrated circuit simultaneously and in described reception antenna receiving body is sent to external hemorheology letterNumber, the hemorheology signal received is sent extremely by described second radio-frequency (RF) receiving and transmission module through described processor and transport moduleDescribed work station.

3. hemorheology monitoring device based on heart coronary artery support as claimed in claim 1, it is characterised in thatDescribed heart coronary artery support includes plural bracing structure and some longitudinal support structure, each describedBracing structure is bent to form ring support by a tinsel, by some friendships between ring support described in adjacent twoThe wrong described longitudinal support structure arranged is fixing to be connected, and forms network structure after making support strut, and described heart coronaries is movedPulsation frame is configured to by two isometric joints, and the one end often saving described support is all connected with ic output described in,The other end often saving described support is respectively arranged with insulant.

4. hemorheology monitoring device based on heart coronary artery support as claimed in claim 3, it is characterised in thatDescribed ring support uses sinusoidal configuration or sawtooth waveforms structure.

5. the hemorheology monitoring device based on heart coronary artery support as described in claim 3 or 4, its featureBeing, described heart coronary artery support is set to as resonant frequency f of antenna:

$\frac{1}{f}=C_{1}N+C_{2}n+C_{3}l$

In formula, N be the quantity of ring support, n be the fluctuating quantity of waveform in ring support, l be longitudinal support structureLength, C₁、C₂And C₃It is positive coefficient.

Hemorheology monitoring device based on heart coronary artery support the most as claimed in claim 1 or 2 or 3 or 4,It is characterized in that, described integrated circuit uses string configuration, and strip integrated circuit props up along described heart coronary arteryFrame is axial arranged.

Hemorheology monitoring device based on heart coronary artery support the most as claimed in claim 1 or 2 or 3 or 4,It is characterized in that, described integrated circuit uses square structure, is wrapped in its outside biological compatibility shell and uses circleShape structure.

Hemorheology monitoring device based on heart coronary artery support the most as claimed in claim 1 or 2 or 3 or 4,It is characterized in that, described integrated circuit uses loop configuration, annular integrated circuit place plane to move with described heart coronariesThe tangent plane of pulsation frame is parallel.

9. based on a monitoring method for hemorheology monitoring device, its feature as described in any one of claim 1～8It is, including herein below:

1) arrange one and include hemorheology detection module, data processor, the first radio-frequency (RF) receiving and transmission module and external treatmentThe hemorheology monitoring device of equipment, wherein, external processing apparatus include reception antenna, the second radio-frequency (RF) receiving and transmission module,Processor, transport module and work station；

2) hemorheology detection module gathers the hemorheology signal of heart coronary artery stented vessel, and by dataReason device transmits after processing to the first radio-frequency (RF) receiving and transmission module, and the hemorheology signal received is carried out by the first radio-frequency (RF) receiving and transmission moduleIt is sent to external processing apparatus by antenna after modulation；

3) the hemorheology signal in the heart coronary artery stented vessel that reception antenna will receive is through the second radio-frequency receiving-transmittingIt is sent to work station after module is demodulated and after the process of treated device.