技术领域technical field
本发明属于医疗器械技术领域，尤其是一种带标记的可视输尿管肾镜负压清石测压扩张鞘套件。The invention belongs to the technical field of medical devices, in particular to a marked visible ureteral nephroscope negative pressure stone clearing manometry expansion sheath set.
背景技术Background technique
输尿管扩张鞘套件包含扩张管和扩张管外鞘两大部分，在临床上主要应用于输尿管、膀胱、肾脏内取结石，进行相关手术治疗建立手术通道所用，通过扩张管外鞘通道导入输尿管肾镜、激光光纤、取石器械或操作缆线等，手术步骤：在医学影像下，经尿道外口置入一斑马导丝，在斑马导丝引导下置入扩张鞘套件至取石部位，拔出扩张管及斑马导丝，通过扩张管外鞘导入输尿管肾镜、激光光纤、取石器械或操作缆线等至输尿管、膀胱、或肾盂，在激光碎石的过程中必须边注水以保护镜头同时碎石能随液体经鞘管通道流出体外，残余的经人体尿道随尿液排出体外。但是在注水过程中会导致肾盂内压力超过肾盂安全压力，增加手术风险。现有技术中的输尿管扩张鞘套件一般都是单腔，在碎石的过程中难以通过扩张鞘监测肾盂压力。现有技术中的扩张鞘套件在碎石后碎石经液体流出体外是通过自然压力，速度比较缓慢而且排出不彻底。The ureteral dilatation sheath kit consists of two parts: the dilation tube and the dilation tube outer sheath. It is mainly used clinically to remove stones in the ureter, bladder, and kidney, and to establish a surgical channel for related surgical treatment. It is used to guide the ureter through the dilation tube outer sheath channel , laser optical fiber, stone extraction equipment or operating cables, etc., surgical steps: under medical imaging, insert a zebra guide wire through the external opening of the urethra, insert the expansion sheath kit to the stone extraction site under the guidance of the zebra guide wire, and pull out the expansion tube And the zebra guide wire, through the expansion sheath into the uretero-nephroscope, laser optical fiber, stone removal equipment or operation cable to the ureter, bladder, or renal pelvis, water must be injected during the process of laser lithotripsy to protect the lens while the lithotripsy can The liquid flows out of the body through the sheath channel, and the residual is excreted through the urethra of the human body with urine. However, during the water injection process, the pressure in the renal pelvis will exceed the safe pressure of the renal pelvis, which increases the risk of surgery. The ureteral expansion sheath sets in the prior art are generally single-lumen, and it is difficult to monitor the renal pelvis pressure through the expansion sheath during lithotripsy. In the expansion sheath set in the prior art, after crushing stones, the stones flow out of the body through liquid through natural pressure, and the speed is relatively slow and the discharge is not complete.
发明内容Contents of the invention
本发明要解决的技术问题是提供一种带标记的可视输尿管肾镜负压清石测压扩张鞘套件，能够解决现有技术的不足，提高了手术的安全性和碎石排出的顺畅度。The technical problem to be solved by the present invention is to provide a marked visual ureteral nephroscope negative pressure stone clearing stone clearing pressure measurement expansion sheath kit, which can solve the deficiencies of the prior art and improve the safety of the operation and the smoothness of stone discharge .
为解决上述技术问题，本发明所采取的技术方案如下。In order to solve the above technical problems, the technical solutions adopted by the present invention are as follows.
一种带标记的可视输尿管肾镜负压清石测压扩张鞘套件，包括鞘管管体，鞘管管体的内部选择性插接有扩张管，所述鞘管管体内设置有大腔通道和小腔通道，鞘管管体的顶部设置有鞘管接头，鞘管接头的一侧设置有压力检测通道，小腔通道与压力检测通道相连通。A marked dilatation sheath set for negative pressure stone clearing and manometry of visual uretero-nephroscope, comprising a sheath tube body, a dilation tube is selectively inserted into the inside of the sheath tube body, and a large cavity is arranged in the sheath tube body The channel and the small cavity channel, the top of the sheath tube body is provided with a sheath tube joint, and one side of the sheath tube joint is provided with a pressure detection channel, and the small cavity channel communicates with the pressure detection channel.
作为优选，所述鞘管接头的顶部设置有负压清石通道主体，负压清石通道主体的顶部设置有负压清石通道上盖，负压清石通道主体和负压清石通道上盖之间设置有硅胶阀，负压清石通道主体的一侧设置有负压清石吸附通道，大腔通道与负压清石吸附通道相连通。As a preference, the top of the sheath joint is provided with a negative pressure stone clearing channel main body, the top of the negative pressure stone clearing channel main body is provided with a negative pressure stone clearing channel upper cover, the negative pressure stone clearing channel main body and the negative pressure stone clearing channel A silica gel valve is arranged between the covers, and one side of the main body of the negative pressure stone removal channel is provided with a negative pressure stone removal adsorption channel, and the large cavity channel is connected with the negative pressure stone removal adsorption channel.
作为优选，所述扩张管的顶部设置有扩张管固定夹。Preferably, the top of the expansion tube is provided with an expansion tube fixing clip.
作为优选，所述鞘管管体采用透明材料制作，扩张管的顶部设置为软性的楔形结构。Preferably, the sheath tube body is made of transparent material, and the top of the expansion tube is configured as a soft wedge-shaped structure.
作为优选，所述鞘管管体的表面设置有刻度标示。Preferably, the surface of the sheath body is provided with scale markings.
作为优选，所述鞘管管体的前端设计有显影环。Preferably, a developing ring is designed at the front end of the sheath body.
作为优选，所述鞘管管体的侧壁内设置有空腔，空腔的底部设置有第一缓冲腔，空腔的顶部设置有第二缓冲腔，第一缓冲腔和第二缓冲腔之间设置有中间腔，中间腔与大腔通道相连通，中间腔与大腔通道之间设置有隔膜，隔膜的一端与鞘管管体相连接，隔膜的另一端与鞘管管体相分离，隔膜内设置有充气腔，充气腔连通有充气管，中间腔与第一缓冲腔的连接处设置有缩口，中间腔与第二缓冲腔之间设置有弧形连接面。Preferably, a cavity is provided in the side wall of the sheath body, a first buffer cavity is provided at the bottom of the cavity, a second buffer cavity is provided at the top of the cavity, and a gap between the first buffer cavity and the second buffer cavity is provided. There is an intermediate cavity between them, the intermediate cavity communicates with the large cavity channel, a diaphragm is arranged between the intermediate cavity and the large cavity channel, one end of the diaphragm is connected with the sheath tube body, and the other end of the diaphragm is separated from the sheath tube body, An inflatable cavity is arranged in the diaphragm, the inflatable cavity is connected with an inflatable tube, a constriction is provided at the connection between the intermediate cavity and the first buffer cavity, and an arc-shaped connecting surface is arranged between the intermediate cavity and the second buffer cavity.
作为优选，所述扩张管的侧壁设置有环形凸缘，环形凸缘的两侧设置有第一气囊层，环形凸缘的顶部设置有凹槽。Preferably, the side wall of the expansion tube is provided with an annular flange, the two sides of the annular flange are provided with the first air bag layer, and the top of the annular flange is provided with a groove.
作为优选，所述负压清石吸附通道内设置有滑槽，滑槽内滑动卡接有橡胶环，橡胶环的内侧均匀设置有若干个橡胶挡片，相邻的橡胶挡片相互分离。As a preference, a chute is provided in the negative pressure stone-cleaning adsorption channel, and a rubber ring is slid and clamped in the chute, and several rubber baffles are uniformly arranged on the inner side of the rubber ring, and adjacent rubber baffles are separated from each other.
采用上述技术方案所带来的有益效果在于：鞘管管体采用透明材料制作，置入器械时通过肾镜能方便观察输尿管的狭窄等病变情况，鞘管管体上标示有刻度，扩张鞘进入输尿管多长有显示，给临床手术以很大的帮助。扩张管的顶部设置为软性的楔形结构，使得置入输尿管和尿道时不损伤输尿管内壁和括约肌，并有效缩短了置管手术的时间。鞘管管体的前端设计有显影环，医生在手术时，通过肾镜可清楚观看到扩张鞘前端进入输尿管或肾盂的具体位置，避免了盲插，减少手术风险。鞘管管体设计成双腔，通过压力监测通道小腔通道连接压力传感器至监护仪，能够有效及时的读取肾盂压力，通过调节手术过程中的肾镜的注水速度和负压清石吸附通道的吸出速度，从而有效保证手术过程中肾盂压力处于安全压力范围内，提高手术安全性。空腔可以对负压清石过程的负压吸取过程进行调节，通过改变充气腔的膨胀度，可以改变隔膜的弹性形变能力，从而在注水和吸取的过程中，可以利用空腔对于水压进行实时调整。第一缓冲腔用来对水流进行缓冲吸收和加压释放，第二缓冲腔用来对进出第一缓冲腔的水流进行二次循环缓冲，从而实现整个注水和吸取过程的平稳性。扩张管的结构是根据鞘管管体的双腔结构进行进一步优化的，通过利用双腔结构，环形凸缘可以提高扩张管的扩张作用，气囊层用来对扩张管的扩张作用力进行分散，从而减少患者的不适感，并且提高扩张的均匀性。凹槽有助于扩张过程中积液的排出，提高扩张的顺畅性。负压清石吸附通道的内部结构是根据鞘管管体的侧壁内设置空腔来进行进一步优化的，在空腔对于压力的调控下，较大体积的碎石在遇到橡胶挡片后会对橡胶挡片、橡胶环产生挤压，改变水流流通截面积，从而对空腔的压力调整进行反馈，以便水压发生变化，将迅速碎石排出。The beneficial effect of adopting the above-mentioned technical scheme is that: the sheath tube body is made of transparent material, and the ureteral stenosis and other lesions can be easily observed through the nephroscope when the device is inserted. The length of the ureter is shown, which is of great help to clinical operations. The top of the expansion tube is set as a soft wedge-shaped structure, so that the inner wall of the ureter and the sphincter are not damaged when the ureter and the urethra are inserted, and the time of the tube insertion operation is effectively shortened. The front end of the sheath tube is designed with a developing ring. During the operation, the doctor can clearly see the specific position where the front end of the expansion sheath enters the ureter or renal pelvis through the nephroscope, avoiding blind insertion and reducing surgical risks. The sheath tube body is designed as a double cavity, and the pressure sensor is connected to the monitor through the small cavity channel of the pressure monitoring channel, which can effectively and timely read the pressure of the renal pelvis, and adjust the water injection speed of the nephroscope and the negative pressure stone removal channel during the operation The suction speed can effectively ensure that the pressure of the renal pelvis is within the safe pressure range during the operation and improve the safety of the operation. The cavity can adjust the negative pressure suction process of the negative pressure stone cleaning process. By changing the expansion degree of the inflatable cavity, the elastic deformation capacity of the diaphragm can be changed, so that the cavity can be used to control the water pressure during the process of water injection and suction. Adjust in real time. The first buffer chamber is used to absorb and release the water flow, and the second buffer chamber is used to buffer the water flow in and out of the first buffer chamber for a second cycle, so as to achieve the stability of the entire water injection and suction process. The structure of the dilation tube is further optimized according to the double-chamber structure of the sheath tube body. By using the double-chamber structure, the annular flange can improve the dilation effect of the dilation tube, and the balloon layer is used to disperse the expansion force of the dilation tube. Thereby reducing patient discomfort and improving the uniformity of dilation. The grooves are helpful for the discharge of the effusion during the expansion process and improve the smoothness of the expansion. The internal structure of the negative pressure stone removal channel is further optimized according to the cavity provided in the side wall of the sheath tube body. Under the control of the pressure of the cavity, the larger volume of gravel will be removed after encountering the rubber stopper. It will squeeze the rubber baffle and the rubber ring, change the cross-sectional area of the water flow, and thus give feedback to the pressure adjustment of the cavity, so that the water pressure will change and the gravel will be discharged quickly.
附图说明Description of drawings
图1是本发明一个实施例的结构示意图。Fig. 1 is a structural schematic diagram of an embodiment of the present invention.
图2是本发明一个实施例中鞘管管体的截面图。Fig. 2 is a cross-sectional view of the sheath tube in one embodiment of the present invention.
图3是本发明一个实施例中空腔的结构图。Fig. 3 is a structural diagram of a cavity in an embodiment of the present invention.
图4是本发明一个实施例中环形凸缘的结构图。Fig. 4 is a structural diagram of an annular flange in an embodiment of the present invention.
图5是本发明一个实施例中负压清石吸附通道。Fig. 5 is a negative pressure stone-cleaning adsorption channel in an embodiment of the present invention.
图中：1、鞘管管体；2、扩张管；3、大腔通道；4、小腔通道；5、鞘管接头；6、压力检测通道；7、负压清石通道主体；8、负压清石通道上盖；9、硅胶阀；10、负压清石吸附通道；11、扩张管固定夹；12、刻度标示；13、显影环；14、空腔；15、第一缓冲腔；16、第二缓冲腔；17、中间腔；18、隔膜；19、充气腔；20、充气管；21、缩口；22、弧形连接面；23、环形凸缘；24、第一气囊层；25、凹槽；26、滑槽；27、橡胶环；28、橡胶挡片；29、第二气囊层。In the figure: 1. Sheath tube body; 2. Expansion tube; 3. Large cavity channel; 4. Small cavity channel; 5. Sheath tube joint; 6. Pressure detection channel; Negative pressure stone cleaning channel upper cover; 9. Silicone valve; 10. Negative pressure stone cleaning channel; 11. Expansion tube fixing clip; 12. Scale mark; 13. Developing ring; 14. Cavity; 15. First buffer chamber ; 16, the second buffer cavity; 17, the middle cavity; 18, the diaphragm; 19, the inflatable cavity; 20, the inflatable tube; layer; 25, groove; 26, chute; 27, rubber ring; 28, rubber baffle; 29, the second air bag layer.
具体实施方式detailed description
参照图1-5，本发明一个具体实施方式包括鞘管管体1，鞘管管体1的内部选择性插接有扩张管2，所述鞘管管体1内设置有大腔通道3和小腔通道4，鞘管管体1的顶部设置有鞘管接头5，鞘管接头5的一侧设置有压力检测通道6，小腔通道4与压力检测通道6相连通。所述鞘管接头5的顶部设置有负压清石通道主体7，负压清石通道主体7的顶部设置有负压清石通道上盖8，负压清石通道主体7和负压清石通道上盖8之间设置有硅胶阀9，负压清石通道主体7的一侧设置有负压清石吸附通道10，大腔通道3与负压清石吸附通道10相连通。扩张管2的顶部设置有扩张管固定夹11。所述鞘管管体1采用透明材料制作，扩张管2的顶部设置为软性的楔形结构。所述鞘管管体1的表面设置有刻度标示12。所述鞘管管体1的前端设计有显影环13。所述鞘管管体1的侧壁内设置有空腔14，空腔14的底部设置有第一缓冲腔15，空腔14的顶部设置有第二缓冲腔16，第一缓冲腔15和第二缓冲腔16之间设置有中间腔17，中间腔17与大腔通道3相连通，中间腔17与大腔通道3之间设置有隔膜18，隔膜18的一端与鞘管管体1相连接，隔膜18的另一端与鞘管管体1相分离，隔膜18内设置有充气腔19，充气腔19连通有充气管20，中间腔17与第一缓冲腔15的连接处设置有缩口21，中间腔17与第二缓冲腔16之间设置有弧形连接面22。所述扩张管2的侧壁设置有环形凸缘23，环形凸缘23的两侧设置有第一气囊层24，环形凸缘23的顶部设置有凹槽25。所述负压清石吸附通道10内设置有滑槽26，滑槽26内滑动卡接有橡胶环27，橡胶环27的内侧均匀设置有若干个橡胶挡片28，相邻的橡胶挡片28相互分离。Referring to Figures 1-5, a specific embodiment of the present invention includes a sheath tube body 1, a dilator tube 2 is selectively inserted inside the sheath tube body 1, and a large lumen channel 3 and The small cavity channel 4 is provided with a sheath tube joint 5 on the top of the sheath tube body 1 , and a pressure detection channel 6 is provided on one side of the sheath tube joint 5 , and the small cavity channel 4 communicates with the pressure detection channel 6 . The top of the sheath joint 5 is provided with a negative pressure stone removal channel main body 7, and the top of the negative pressure stone removal channel main body 7 is provided with a negative pressure stone removal channel upper cover 8, the negative pressure stone removal channel main body 7 and the negative pressure stone removal channel A silica gel valve 9 is arranged between the passage upper covers 8, and a negative pressure stone removal adsorption channel 10 is arranged on one side of the negative pressure stone removal channel main body 7, and the large chamber channel 3 communicates with the negative pressure stone removal adsorption channel 10. The top of the expansion tube 2 is provided with an expansion tube fixing clip 11 . The sheath tube body 1 is made of transparent material, and the top of the expansion tube 2 is set as a soft wedge-shaped structure. The surface of the sheath body 1 is provided with scale marks 12 . A developing ring 13 is designed at the front end of the sheath body 1 . The side wall of the sheath tube body 1 is provided with a cavity 14, the bottom of the cavity 14 is provided with a first buffer cavity 15, the top of the cavity 14 is provided with a second buffer cavity 16, the first buffer cavity 15 and the second buffer cavity An intermediate chamber 17 is arranged between the two buffer chambers 16, the intermediate chamber 17 communicates with the large chamber channel 3, and a diaphragm 18 is arranged between the intermediate chamber 17 and the large chamber channel 3, and one end of the diaphragm 18 is connected with the sheath tube body 1 , the other end of the diaphragm 18 is separated from the sheath tube body 1, the diaphragm 18 is provided with an inflatable chamber 19, the inflatable chamber 19 communicates with an inflatable tube 20, and the connection between the intermediate chamber 17 and the first buffer chamber 15 is provided with a constriction 21 , An arc-shaped connection surface 22 is provided between the intermediate cavity 17 and the second buffer cavity 16 . The side wall of the expansion tube 2 is provided with an annular flange 23 , the two sides of the annular flange 23 are provided with the first air bag layer 24 , and the top of the annular flange 23 is provided with a groove 25 . A chute 26 is arranged in the negative pressure stone-clearing adsorption channel 10, and a rubber ring 27 is slidingly clamped in the chute 26, and several rubber baffles 28 are evenly arranged on the inner side of the rubber ring 27, and the adjacent rubber baffles 28 separated from each other.
另外，在空腔14的内侧设置有第二气囊层29。第二气囊层29在受到中间腔17、第一缓冲腔15和第二缓冲腔16的不同压力时，会发生相应的弹性形变，通过第二气囊层29的弹性形变，可以实时改变中间腔17、第一缓冲腔15和第二缓冲腔16的容积，从而实现水流流动压力的二次缓冲调节。In addition, a second airbag layer 29 is provided inside the cavity 14 . When the second airbag layer 29 is subjected to different pressures from the intermediate chamber 17, the first buffer chamber 15, and the second buffer chamber 16, corresponding elastic deformations will occur. Through the elastic deformation of the second airbag layer 29, the intermediate chamber 17 can be changed in real time. , the volumes of the first buffer chamber 15 and the second buffer chamber 16, so as to realize the secondary buffer adjustment of the flow pressure of the water flow.
本发明可以明显提高手术的安全性和碎石排出的顺畅度。The invention can obviously improve the safety of the operation and the smoothness of discharging the crushed stones.
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。The basic principles and main features of the present invention and the advantages of the present invention have been shown and described above. Those skilled in the industry should understand that the present invention is not limited by the above-mentioned embodiments. What are described in the above-mentioned embodiments and the description only illustrate the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention will also have Variations and improvements are possible, which fall within the scope of the claimed invention. The protection scope of the present invention is defined by the appended claims and their equivalents.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510719396.XACN105380716B (en) | 2015-10-30 | 2015-10-30 | Visible uretero-nephroscope negative pressure stone-removing pressure-measuring expanding sheath assembly with mark |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510719396.XACN105380716B (en) | 2015-10-30 | 2015-10-30 | Visible uretero-nephroscope negative pressure stone-removing pressure-measuring expanding sheath assembly with mark |
| Publication Number | Publication Date |
|---|---|
| CN105380716Atrue CN105380716A (en) | 2016-03-09 |
| CN105380716B CN105380716B (en) | 2018-06-01 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510719396.XAActiveCN105380716B (en) | 2015-10-30 | 2015-10-30 | Visible uretero-nephroscope negative pressure stone-removing pressure-measuring expanding sheath assembly with mark |
| Country | Link |
|---|---|
| CN (1) | CN105380716B (en) |
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| WO2007027830A1 (en)* | 2005-08-31 | 2007-03-08 | Vance Products Incorporated | Coaxial dilatation method for stent implantation |
| CN101836853A (en)* | 2009-03-18 | 2010-09-22 | 理查德·沃尔夫有限公司 | Ureterorenoscope |
| CN204428598U (en)* | 2015-01-27 | 2015-07-01 | 山西瑞克普生物科技有限公司 | A kind of dilatation of ureter sheath |
| CN204520868U (en)* | 2015-01-29 | 2015-08-05 | 深圳市康医博科技发展有限公司 | A kind of Wicresoft expansion two-chamber ureter guiding sheath external member |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040181273A1 (en)* | 2003-03-10 | 2004-09-16 | Evan Brasington | Dilator with expandable member |
| WO2007027830A1 (en)* | 2005-08-31 | 2007-03-08 | Vance Products Incorporated | Coaxial dilatation method for stent implantation |
| CN101836853A (en)* | 2009-03-18 | 2010-09-22 | 理查德·沃尔夫有限公司 | Ureterorenoscope |
| CN204428598U (en)* | 2015-01-27 | 2015-07-01 | 山西瑞克普生物科技有限公司 | A kind of dilatation of ureter sheath |
| CN204520868U (en)* | 2015-01-29 | 2015-08-05 | 深圳市康医博科技发展有限公司 | A kind of Wicresoft expansion two-chamber ureter guiding sheath external member |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108175483A (en)* | 2018-02-22 | 2018-06-19 | 上海英诺伟医疗器械有限公司 | Visual guidance sheath |
| CN109589155A (en)* | 2018-11-12 | 2019-04-09 | 孟祥锋 | A kind of Urology Surgery lithangiuria calculus removing instrument |
| CN109984717A (en)* | 2019-04-27 | 2019-07-09 | 湖南普方德医疗发展有限公司 | Combined type ureterorenoscope |
| CN111227853A (en)* | 2020-03-10 | 2020-06-05 | 海盐康源医疗器械有限公司 | Pressure-measuring visual expansion suction sheath |
| CN115531689A (en)* | 2022-08-31 | 2022-12-30 | 湖南省华芯医疗器械有限公司 | A front end assembly of a ureteral sheath, a ureteral sheath and a device for inserting into the ureter |
| WO2025067139A1 (en)* | 2023-09-26 | 2025-04-03 | 济南凯特工贸有限公司 | Bendable and visible negative pressure suction ureteral access sheath |
| Publication number | Publication date |
|---|---|
| CN105380716B (en) | 2018-06-01 |
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| C10 | Entry into substantive examination | ||
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| CB03 | Change of inventor or designer information | Inventor after:Liu Qigui Inventor after:Ma Weiqing Inventor after:Liu Xu Inventor before:Liu Qigui Inventor before:Ma Weiqing Inventor before:Liu Xu | |
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information | Inventor after:Liu Xu Inventor before:Liu Qigui Inventor before:Ma Weiqing Inventor before:Liu Xu | |
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right | Effective date of registration:20200408 Address after:518000 Room 201, building 6, No. 19, Alishan Road, Songshanhu Park, Dongguan City, Guangdong Province Patentee after:Guangdong Tianyou medical device technology development Co., Ltd Address before:Longgang District of Shenzhen City, Guangdong province 518021 Avenue Longxin waterfront Xindu four or five 41 floor A1501 Patentee before:Liu Xu | |
| TR01 | Transfer of patent right |