Chinese medicine composition for the treatment of prostatitis and prostate hyperplasia and preparation method thereofTechnical field
The present invention relates to field of medicaments, be specifically related to a kind ofly treat Chinese medicine composition of prostatitis and prostate hyperplasia and preparation method thereof.
Background technology
Prostatosis is prostatitis and prostate hyperplasia particularly, is the frequently-occurring disease of traditional Chinese medical science andrology, commonly encountered diseases, a lot of about this sick method for the treatment of, but poor effect.
Prostatitis is the inflammation of body of prostate and the glandular tube caused by antibacterial, virus or its toxin.Primary disease divides acute and chronic two kinds, wherein the most common with chronic prostatitis, and many and posterior urethritis, seminal vesiculitis or epididymis inflammation exist simultaneously.Primary disease is multiple is born in person between twenty and fifty, but elderly men is also not rare, and often can cause urinary tract infection.
The traditional Chinese medical science thinks that the multifactor body of prostatitis is weak, deficiency of kidney-QI, or because being addicted to drink and rich and fatty diet, causes coagulation of QI-blood, retention of damp-heat in the interior; Or because of intemperate sexual intercourse, kidney yin loss, deficiency of YIN affecting YANG, and cause imbalance of YIN and YANG in kidney.
Prostate hyperplasia, also known as hyperplasia of prostate, is the commonly encountered diseases of male old man.After 50 years old, most male has the change of prostate hyperplasia, but clinically again can completely without symptom.Think that its pathogenic factor may be relevant with old people's gonadal hormone dysequilibrium at present.Research in recent years proves, cholesterol accumulation is also one of major reason; Secrete urgent urethra, cause dysuria, notably the inaccessible urinary dysfunction such as obstructed of urine.Primary disease belongs to the scope such as the difficulty in urination, stranguria in motherland's medical science.Generally show as number of micturitions to increase, evening is particularly remarkable, and urination time is long, and a period of time need be waited to discharge, and course advancement is slow.Along with aggravation, need hold one's breath firmly when urinating, urine need can be discharged by abdominal muscle strength; Frequent micturition, urgent micturition, urine line attenuates, and each voided volume reduces, and urine can only be that drop is discharged, and conscious urine can not drain, and sometimes can cause acute urinary retention.
Damp-heat accumulation, kidney qi virtual loss, stagnation of blood stasis is the loose main pathogenesis of chronic prostatitis, and wherein damp-heat accumulation shows comparatively outstanding when acute attack.Kidney qi virtual loss is the most common when obstinate disease, and stagnation of blood stasis then runs through disease all the time.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of prostatitis and prostate hyperplasia.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of prostatitis and prostate hyperplasia.
Another object of the present invention is to provide a kind of injection for the treatment of the Chinese medicine composition of prostatitis and prostate hyperplasia.
The object of the invention is to be achieved through the following technical solutions:
The Chinese medicine composition for the treatment of prostatitis of the present invention and prostate hyperplasia is prepared from by the raw material comprising following weight portion: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 80 ~ 150 parts, 1 ~ 5 part, Moschus, Caulis Gneti 15 ~ 30 parts, Herba Solani Nigri 15 ~ 30 parts.
The Chinese medicine composition for the treatment of prostatitis of the present invention and prostate hyperplasia is prepared from by the raw material comprising following weight portion: Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 90 ~ 120 parts, 2 ~ 4 parts, Moschus, Caulis Gneti 20 ~ 25 parts, Herba Solani Nigri 20 ~ 25 parts.
Crude drug source of the present invention is as follows:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), formal name used at school: CorydalissaxicolaBunting, is the root of bloodroot Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), adopts after autumn.Bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, dampness removing, analgesic hemostatic.
Moschus is the dry secretions in the ripe male body note capsule of animal in deer family woods Moschus moschiferous MoschusberezovskiiFlerov, horse Moschus moschiferous MoschussifanicusPrzewalski or former Moschus moschiferous MoschusmoschiferusLinnaeus.Acrid in the mouth, warm in nature.GUIXIN, spleen channel.To have one's ideas straightened out refreshment, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.For calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, amenorrhea ， WEIJIA, difficult labour stillborn fetus, trusted subordinate's sudden pain, carbuncle scrofula, and laryngopharynx swelling and pain, falls and flutter the pain of injury, and arthralgia pain is numb.
Caulis Gneti is stem and leaf or the root of Gnetaceae plant Caulis Gneti Parvifolii.Bitter; Slightly warm in nature.Expelling wind and removing dampness; Dissipating blood stasis blood; Preventing phlegm from forming and stopping coughing.
Herba Solani Nigri is Solanaceae nightshade Herba Solani Nigri SolanumnigrumL., with all herbal medicine.Hardship, cold.Slightly poisonous.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cat fever, toothache, chronic bronchitis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle is controlled in external, pemphigus, venom.
The Chinese medicine composition for the treatment of prostatitis of the present invention and prostate hyperplasia, its active component is prepared from by following technique:
(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, be ground into coarse powder, is 50 ~ 80% ethanol percolate extraction with the volume by volume concentration being equivalent to medical material gross weight 4 ~ 8 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights, decoct 10 ~ 60 minutes, and filter, filtrate and percolate merge, and are concentrated into 2 ~ 3 times of medical material gross weight, filter, and leave standstill 1 ~ 10 day, get supernatant, obtain solution A;
(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 60 ~ 120 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 60 ~ 90 times, merges distillate, obtains solution B;
(3) merge solution A and solution B, obtain inventive compound.
The Chinese medicine for the treatment of prostatitis of the present invention and prostate hyperplasia, its active component is preferably prepared from by following technique:
(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 50 ~ 60% with the volume by volume concentration being equivalent to medical material gross weight 5 ~ 6 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights, decoct 20 ~ 40 minutes, and filter, filtrate and percolate merge, and are concentrated into 2 ~ 3 times of medical material gross weight, filter, and leave standstill 2 ~ 3 days, get supernatant, obtain solution A;
(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 92 ~ 100 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 70 ~ 80 times, merges distillate, obtains solution B;
(3) merge solution A and solution B, obtain inventive compound.
The Chinese medicine composition composition injection for the treatment of prostatitis of the present invention and prostate hyperplasia is prepared from by following technique:
(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 50 ~ 80% with the volume by volume concentration being equivalent to medical material gross weight 4 ~ 8 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 ~ 3 times of medical material gross weights again, decoct 10 ~ 60 minutes, filter, filtrate and percolate merge, and regulate pH to 3 ~ 4 with dilute hydrochloric acid solution, leave standstill half an hour, elimination precipitate, regulate pH to 6.5 ~ 7.5 with sodium hydroxide solution again, reclaim ethanol, be concentrated into 2 ~ 3 times of medical material gross weight, filter, leave standstill 3 ~ 10 days, get supernatant, obtain solution A;
(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 60 ~ 120 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 60 ~ 90 times, merges distillate, obtains solution B;
(3) merge solution A and solution B, add the surfactant of 0.5% ~ 1%, mix homogeneously, regulate pH to 8.5, filter, fill, sterilizing, to obtain final product.
The Chinese medicine composition of prostatitis of the present invention and prostate hyperplasia, with pharmaceutically acceptable carrier combination, can make various preparation.
Chinese medicine of the present invention can make injection, treats in the mode of acupoint injection therapy, also can be prepared into various oral formulations or other dosage form use be applicable to.
Chinese medicine of the present invention has extraordinary effect for treatment prostatitis and prostate hyperplasia, have rapid-action, curative effect is good, the feature such as have no side effect, clinical test results treatment prostatitis total effective rate reaches 91.3%, treatment prostate hyperplasia total effective rate reaches 93.5%, achieves important breakthrough relative to prior art, has outstanding substantive distinguishing features and significant progress.
Embodiment 1
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 800g Moschus 10g Caulis Gneti 150g Herba Solani Nigri 150.
, Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, being ground into coarse powder, is the ethanol percolate extraction of 50% with 4800g volume by volume concentration, to extract solution stores for subsequent use, and medicinal residues add the water of 2400g again, decoct 10 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 2400g, filter, leave standstill 1 day, get supernatant, obtain solution A;
(2), get Moschus, pulverize, distillation twice, adds the water of 920g at every turn, and each collection 600g distillate, merges distillate, obtain solution B;
(3), merge solution A and solution B, obtain inventive compound.
Embodiment 2
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1500g Moschus 50g Caulis Gneti 300g Herba Solani Nigri 300g
(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 80% with 16800g volume by volume concentration, to extract solution stores for subsequent use, and medicinal residues add the water of 6300g again, decoct 30 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 6300g, filter, leave standstill 2 days, get supernatant, obtain solution A;
(2), get Moschus, pulverize, distillation twice, adds the water of 6000g at every turn, and each collection 4500g distillate, merges distillate, obtain solution B;
(3), merge solution A and solution B, add the Tween 80 of 0.5%, mix homogeneously, regulate PH to 8.5, filter, fill, sterilizing, obtains injection of the present invention.
Embodiment 3
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1200g Moschus 40g Caulis Gneti 250g Herba Solani Nigri 250g
(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 60% with 8500g volume by volume concentration, to extract solution stores for subsequent use, and medicinal residues add the water of 5100g again, decoct 20 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 3400g, filter, leave standstill 3 days, get supernatant, obtain solution A;
(2), get Moschus, pulverize, distillation twice, adds the water of 4000g at every turn, and each collection 3600g distillate, merges distillate, obtain solution B;
(3), merge solution A and solution B,
After being concentrated into suitable relative density, mix with appropriate amount of starch and dextrin, granulate, dry, tabletting, obtains tablet of the present invention.
Embodiment 4
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 900g Moschus 20g Caulis Gneti 200g Herba Solani Nigri 200g
(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 60% with 7800g volume by volume concentration, to extract solution stores for subsequent use, and medicinal residues add the water of 2600g again, decoct 20 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 3900g, filter, leave standstill 10 days, get supernatant, obtain solution A;
(2), get Moschus, pulverize, distillation twice, adds the water of 1200g at every turn, and each collection 1400g distillate, merges distillate, obtain solution B;
(3), merge solution A and solution B, obtain inventive compound;
(4), by active component mix with suitable amount of sucrose and antiseptic, add water to 10000g, obtain oral liquid of the present invention.
Embodiment 5
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 950g Moschus 30g Caulis Gneti 220g Herba Solani Nigri 220g
(1), getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, herb of Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 70% with 8000g volume by volume concentration, to extract solution stores for subsequent use, and medicinal residues add the water of 3000g again, decoct 20 minutes, filter, merge with percolate, reclaim ethanol, be concentrated into 4000g, filter, leave standstill 3 days, get supernatant, obtain solution A;
(2), get Moschus, pulverize, distillation twice, adds the water of 2760g at every turn, and each collection 2400g distillate, merges distillate, obtain solution B;
(3), merge solution A and solution B,
To put in vacuum drying oven 70 DEG C and dry, pulverize 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, make granule, dry, incapsulate, obtain capsule of the present invention.
Embodiment 6
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 900g Moschus 20g Caulis Gneti 200g Herba Solani Nigri 200g
(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 50% with the volume by volume concentration being equivalent to medical material gross weight 4 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 2 times of medical material gross weights again, decoct 10 minutes, filter, filtrate and percolate merge, and regulate pH to 3 with dilute hydrochloric acid solution, leave standstill half an hour, elimination precipitate, regulate pH to 6.5 with sodium hydroxide solution again, reclaim ethanol, be concentrated into 2 times of medical material gross weight, filter, leave standstill 3 days, get supernatant, obtain solution A;
(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 60 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 60 times, merges distillate, obtains solution B;
(3) merge solution A and solution B, add the surfactant of 0.5%, mix homogeneously, regulate pH to 8.5, filter, fill, sterilizing, obtains injection.
Embodiment 7
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) 1200g Moschus 40g Caulis Gneti 250g Herba Solani Nigri 250g
(1) getting Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), Caulis Gneti, Herba Solani Nigri, be ground into coarse powder, is the ethanol percolate extraction of 80% with the volume by volume concentration being equivalent to medical material gross weight 8 times, and percolate reclaims ethanol, for subsequent use; Medicinal residues add the water of 3 times of medical material gross weights again, decoct 60 minutes, filter, filtrate and percolate merge, and regulate pH to 4 with dilute hydrochloric acid solution, leave standstill half an hour, elimination precipitate, regulate pH to 7.5 with sodium hydroxide solution again, reclaim ethanol, be concentrated into 3 times of medical material gross weight, filter, leave standstill 10 days, get supernatant, obtain solution A;
(2) get Moschus, pulverize, distillation twice, adds the water of Moschus medical material weight 120 times at every turn, and each collection is equivalent to the distillate of Moschus medical material weight 90 times, merges distillate, obtains solution B;
(3) merge solution A and solution B, add the surfactant of 1%, mix homogeneously, regulate pH to 8.5, filter, fill, sterilizing, obtains injection.
Clinical efficacy
1, group standard is entered:
Prostatitis diagnosis standard: (1) frequent micturition, urgent micturition, have causalgia sense when urinating in urethra, not to the utmost, common have milky secretions to dribble of urine, especially occurs when urinating whole end and stool; (2) easy lassitude and weak, lumbosacral pain, sexual disorder, merge the diseases such as iritis, arthritis or neuritis sometimes; (3) anus digital examination, prostate normal in size or slightly large, hardness is uneven local tenderness, and it is harder that medical history elder prostate reduces quality; (4) the visible a large amount of pus cell of massage of prostate fluid inspection, lecithin significantly reduces or disappears.
Hyperplasia of prostate diagnostic criteria: (1) frequent micturition, nocturia are cumulative, dysuria, urine line are unable; (2) swollen full, the distending pain of lower abdomen; (3) bladder has remaining urine; (4) digital rectal examination or ultrasound diagnosis find that prostate increases.
All 3 of possessing wherein, can make a definite diagnosis.
2, basic condition: 69 routine patients of selection, wherein prostate hyperplasia 46 example, prostatitis 23 example; 46 ~ 67 years old age, average 56.5 years old; The course of disease is the shortest 1 month, the longest 3 years (to occur that clinical symptoms is for date of the onset).All use Western medicine antiinflammatory, symptomatic treatment mistake, all make a definite diagnosis through clinical manifestation, rectal touch, ultrasound diagnosis.
3, Therapeutic Method:
The embodiment of the present invention 2 injection is used to be dissolved in the glucose intravenous drip of 5%, every day 1 time.
4, criterion of therapeutical effect:
Recovery from illness: symptom, sign disappear, ultrasound diagnosis prostate changes and hypertrophy without inflammatory;
Take a turn for the better: frequent micturition, urgent micturition, interruption of urinating, postpones when starting to urinate, and the partial symptoms such as dysurea disappear, and nocturnal pollakiuria is without improvement, and the prostate that ultrasound diagnosis increases reduces;
Invalid: symptom, sign and ultrasound diagnosis are not improved.
5, therapeutic outcome: in table 1.
Table 1 therapeutic outcome
| Number of cases | Effective | Effectively | Invalid | Total effective rate (%) |
| Prostatitis | 23 | 8 | 13 | 2 | 91.3 |
| Prostatic hyperplasia | 46 | 12 | 31 | 3 | 93.5 |
Table 1 result shows: adopt medicine of the present invention to carry out prostatitis and prostate hyperplasia therapeutic effect ideal, treatment prostatitis total effective rate reaches 91.3%, and treatment prostate hyperplasia total effective rate reaches 93.5%.
Model case:
Huang, man, 47 years old, Zhuang, was diagnosed as urinary system infection, once used more than the medicine intermittent treatment moon such as amikacin, norfloxacin, the dawn pyridine of furan mouth, to our hospital after DeGrain.When coming, ordinary circumstance is good, hypogastric region tenderness (+), and rectal touch contacts loose prostate.Corpulent tongue, thin fur; White urine and tasteless, amount is few; Thready pulse sinks.B ultrasonic display prostatitis.The injection embodiment of the present invention 7, treats recovery from illness in 5 weeks and leaves hospital, follow up a case by regular visits to and do not recur for 6 months.