CN105137097A - Intelligent prothrombin time monitoring system and monitoring method - Google Patents

Abstract

The invention relates to an intelligent prothrombin time monitoring system and monitoring method. The monitoring system comprises a prothrombin time detection terminal, an external processing terminal, a cloud server and a doctor monitoring terminal, wherein the prothrombin time detection terminal is in wired connection with the external processing terminal, the external processing terminal and the doctor monitoring terminal are connected with the cloud server. The monitoring method comprises the following steps that: the prothrombin time detection terminal acquires information on a prothrombin time test strip and transmits the information to the external processing terminal; the external processing terminal determines whether acquired prothrombin time information is within a safety range; and if great deviation occurs, warning information is sent and acquisition and determination results are sent to the doctor monitoring terminal through the cloud server. With a mobile internet system constructed in the invention, a patient can detect coagulation functions at home, a professional doctor can timely learn about the medication state and physical conditions of the patient at anytime and anywhere, labor and time are saved, and occurrence of risks and accidents is prevented.

Description

Intelligence prothrombin time supervisory system and method for supervising thereof

Technical field

The present invention relates to a kind of prothrombin time monitoring equipment, particularly relate to a kind of intelligent prothrombin time supervisory system and method for supervising thereof.

Background technology

Prothrombin time, is called for short PT, refers to that add excessive tissue factor and appropriate calcium ion in the hematoblastic blood plasma of shortage after, conversion of prothrombin is fibrin ferment, causes the time needed for the clotting of plasma.The factor of prothrombin time and blood plasma, fibrinogen and AcG, VII, the level of Ⅹ is relevant.

Prothrombin time is external source blood coagulation system shaker test that is comparatively responsive and that commonly use the most, whether main reflection extrinsic coagulation is normal, its principle is in anticoagulation, add the tissue thromboplastin of q.s and appropriate calcium ion, meet extrinsic coagulation condition, be PT from the time added needed for calcium ion to the clotting of plasma.

PT is by the impact of the many factors such as tissue thromboplastin source difference, instrument and operative technique, and make result outside laboratory internal and laboratory, there is very large difference, therefore WHO started PT standardization with INR in early days the eighties.

INR international normalized ratio is from prothrombin time and the International sensitivity index (ISI measuring reagent, internationalsensitivityindex) calculate out, the PT adopting INR that different experiments room and different reagent are measured has comparability, is convenient to unified medication standard.

The situation of at present being undertaken treating by oral anticoagulation is very general, such as implement the patient of mechanical heart valve displacement technique, need after valve replacement to carry out anticoagulant therapy for a long time or all the life, therapeutic purposes prevent from forming thrombus near artificial valve, ensures the normal operation of valve.If but to take oral anticoagulation improper for patient, can cause failing to respond to any medical treatment, even cause the generation of the complication such as hemorrhage or thromboembolism, seriously jeopardize patient vitals, the detection therefore carrying out daily coagulation function is that oral anticoagulation therapy patient achieves the goal and ensures safe necessary means.

The instrument mainly laboratory equipment that current domestic coagulation function detects, equipment volume is comparatively large, and need professional to safeguard and operate, operating cost is higher.And needs of patients often arrive hospital carry out blood drawing detect, test result can not be known in time again, waste time and energy, very inconvenient, cause adjustment drug dose not prompt enough, there is potential safety hazard.

Summary of the invention

The needs of patients that the present invention mainly solves current dysfunction of blood coagulation often carries out blood drawing detection to hospital, can not know test result in time again, waste time and energy, very inconvenient, causes adjustment drug dose not prompt enough, there is the technical matters of potential safety hazard; A kind of intelligent prothrombin time supervisory system and method for supervising thereof are provided, by the structure of mobile interchange system, patient is in just can detect coagulation function, automatic analysis medicining condition, provides medication dose adjustment suggestion automatically, simultaneously by testing result, medicining condition and suggestion and warning message remote transmission to doctor's monitor terminal, so that medical practitioner can understand patient status in time, provide suggestion or warning in time, time saving and energy saving, avoid the generation of risk or accident.

Above-mentioned technical matters of the present invention is mainly solved by following technical proposals: intelligent prothrombin time supervisory system of the present invention, comprises prothrombin time sense terminals, external treatment terminal and doctor's monitor terminal;

Prothrombin time sense terminals: for detecting prothrombin time, and testing result is sent to described external treatment terminal with wired or wireless communication modes;

External treatment terminal: the prothrombin time testing result receiving the transmission of prothrombin time sense terminals with wired or wireless communication modes, and carry out treatment and analysis, make the judgement whether in safe range, display safety information or the information that gives a warning, provide amount effect curve and regression equation, and above-mentioned information is sent to the doctor's monitor terminal be positioned at described in far-end with wired or wireless communication modes, provide Dynamic Graph directly perceived and data reference to doctor;

Doctor's monitor terminal: carry out wired or wireless communication with described external treatment terminal, for receiving the information that external treatment terminal sends, also can edit also move instruction to described external treatment terminal.The reaction information in prothrombin time test-strips is gathered by prothrombin time sense terminals, flow to external treatment terminal, external treatment terminal by analysis and process, make the judgement whether in safe range, display safety information or the information that gives a warning, provide amount effect curve and regression equation, and with wired or wireless communication modes, above-mentioned information is sent to doctor's monitor terminal of far-end, Dynamic Graph directly perceived and data reference is provided to doctor, so that medical practitioner can understand patient status in time, provide suggestion or warning in time, avoid the trouble that client need usually travels to and fro between hospital and family, time saving and energy saving, avoid the generation of risk or accident.

As preferably, described intelligent prothrombin time supervisory system comprises cloud server: for both carrying out wired or wireless communication with described external treatment terminal, wired or wireless communication is carried out again with described doctor's monitor terminal, ensure the data syn-chronization of external treatment terminal and doctor's monitor terminal, cloud server itself can also automatically externally processing terminal and doctor's monitor terminal push related data.Consider that in actual use procedure, amount of data storage is larger, cloud server can be set up, external treatment terminal and cloud server carry out communication, cloud server and doctor's monitor terminal carry out communication, the data syn-chronization of external treatment terminal and doctor's monitor terminal can be allowed like this, cloud server itself also can automatically externally processing terminal, doctor's monitor terminal push related data.Doctor's monitor terminal can adopt portable mobile apparatus, such as mobile phone, panel computer etc., also can adopt common computer, doctor's monitor terminal be provided with corresponding detection management software, comprise data receiver, editor, the logging in of transmission and cloud server.

As preferably, described prothrombin time sense terminals comprises CPU (central processing unit) and the prothrombin time detecting unit be connected with CPU (central processing unit) respectively, temperature sensor, barcode scanning terminal interface and communication interface;

CPU (central processing unit): the prothrombin time detection signal for sending here prothrombin time detecting unit processes, and according to the actual environment temperature that temperature sensor is sent here, temperature compensation is carried out to prothrombin time detection signal, then prothrombin time testing result is calculated by test-strips parameter information, obtain patient information and test-strips information by barcode scanning terminal interface, connecting communication interface is to carry out data communication with described external treatment terminal;

Prothrombin time detecting unit: for gathering the reaction information in prothrombin time test-strips, obtains prothrombin time detection signal and flows to described CPU (central processing unit);

Temperature sensor: Real-time Collection environment temperature also flows to described CPU (central processing unit), is convenient to CPU (central processing unit) and carries out temperature compensation to prothrombin time testing result;

Barcode scanning terminal interface: for connecting barcode scanning instrument, described CPU (central processing unit) is flowed to by barcode scanning acquisition patient number and name, by barcode scanning automatic acquisition test-strips lot number and the parameter information obtaining this lot number from high in the clouds flows to described CPU (central processing unit), realize automatic size adjusting;

Communication interface: for realizing the data communication of CPU (central processing unit) and described external treatment terminal;

Display module, key-press module, communication module and alarm module that described external treatment terminal comprises ARM controller and is connected with ARM controller respectively;

ARM controller: carry out communication with described prothrombin time sense terminals, treatment and analysis is carried out to the prothrombin time testing result received, make the judgement whether in safe range, display safety information or the information that gives a warning, provide amount effect curve and regression equation, and above-mentioned information is sent by communication module, provide Dynamic Graph directly perceived and data reference to doctor;

Display module: for receiving the data that ARM controller transports, display prothrombin time testing result, display safety information or warning message, show the suggestion of next dosage, display patient information, information about doctor and medication information;

Key-press module: for editing patient name, numbering, medication information, monitoring information, test-strips lot number information and physician name, account, and flow to ARM controller;

Communication module: be connected with ARM controller, realizes the data communication of ARM controller and described doctor's monitor terminal or cloud server;

Alarm module: when ARM controller judges that the prothrombin time testing result received exceedes safe range, start alarm module, give a warning information.

The data memory module be connected with one-chip computer module also can be set as required, the store and management of data of being more convenient for.Temperature sensor Real-time Collection environment temperature, is convenient to carry out temperature compensation to testing result, guarantees that the detection of prothrombin time is more accurate.Barcode scanning terminal interface can connect barcode scanning instrument, obtains patient number and name by barcode scanning.Also by barcode scanning automatic acquisition test-strips lot number, and working code and the parameter of this BT(batch testing) bar is obtained by cloud server, thus realize the function of automatic size adjusting, avoid the result risk brought because of mistake in working code and parameter, improve use convenience, reduce risks.Also can automatic acquisition control liquid lot number by barcode scanning, thus obtain Quality Control range information by cloud server, thus whether realize automatic decision Quality Control result qualified, the impact avoided user error to judge, use problem system to bring, also substantially increases the convenience of use.Communication module can be a wireless module, and prothrombin time sense terminals, the communication of doctor's monitor terminal time share; Also can be an in-plant wireless module and a remote wireless module, in-plant wireless module and the communication of prothrombin time sense terminals, remote wireless module and the communication of doctor's monitor terminal; Also can be a wired module and a wireless module, wired module and the communication of prothrombin time sense terminals, wireless module and the communication of doctor's monitor terminal.If serial ports, USB port, RS232 interface are wired module, NFC module, bluetooth module, Wifi module are near radio module, 2G 3G 4G module be remote-wireless module.Can edit patient name, numbering, medication information, monitoring information, test-strips lot number information and physician name, account etc. by key-press module, medication information comprises nomenclature of drug, oral dose and administration time etc.

As preferably, described prothrombin time sense terminals and external treatment terminal belong to two modules or two specific installations of same equipment.When prothrombin time sense terminals and external treatment terminal belong to same equipment, data bus connection is convenient, but whole equipment volume is bigger.When prothrombin time sense terminals and external treatment terminal are two independent equipment, external treatment terminal can use mobile device popular at present, as smart mobile phone, panel computer etc., it is provided with corresponding prothrombin time monitoring APP software.It is convenient to realize, and operates and uses also very convenient.

The method for supervising of intelligent prothrombin time supervisory system of the present invention is: described prothrombin time sense terminals gathers the information in prothrombin time test-strips, and flow to described external treatment terminal with wired or wireless communication modes, external treatment terminal is according to the prothrombin time desired value preset, by analysis and process, whether the prothrombin time value that automatic decision actual acquisition arrives is in safe range, if deviation is larger, then give a warning information, collection result and judged result are sent to described doctor's monitor terminal with wired or wireless communication modes by external treatment terminal simultaneously.Prothrombin time desired value is provided by medical practitioner suggestion, and warning message can adopt dodges modes such as shielding or pipe.The technical program is convenient to medical practitioner can understand patient status in time, provides adjustment suggestion and handling suggestion in time, avoids the trouble that client need usually travels to and fro between hospital and family, time saving and energy saving, avoids the generation that medical treatment is dangerous.

As preferably, described prothrombin time sense terminals is provided with barcode scanning terminal interface; Described method for supervising comprises: carry out barcode scanning by connecting barcode scanning equipment at described barcode scanning terminal interface to test-strips lot number, by barcode scanning automatic acquisition test-strips lot number, obtained working code and the parameter of this BT(batch testing) bar again by described external treatment terminal and described cloud server communication, realize automatic size adjusting function.Avoid the result risk brought because of mistake in working code and parameter, improve use convenience, reduce risks.Consider that in actual use procedure, amount of data storage is larger, also cloud server can be set up, external treatment terminal and cloud server carry out wireless telecommunications, cloud server and doctor's monitor terminal carry out wireless telecommunications, the data syn-chronization of external treatment terminal and doctor's monitor terminal can be allowed like this, cloud server itself also can automatically externally processing terminal, doctor's monitor terminal push related data.

As preferably, described method for supervising comprises test agent Quality Control detection method, and step is as follows:

1) the barcode scanning device scan test agent bar code described in, obtains test agent lot number information and flows to described external treatment terminal (2);

2) external treatment terminal (2) and described cloud server (4) carry out communication, the Quality Control scope of acquisition or synchronously this lot number test agent;

3) the Quality Control scope of external treatment terminal (2) On-board test reagent lot information and acquisition;

4) the prothrombin time sense terminals (1) described in carries out Quality Control detection to test agent, and testing result is sent to external treatment terminal (2);

5) testing result and the Quality Control scope that obtains before are compared by external treatment terminal (2), provide the qualified or Quality Control result over range warning of Quality Control.

The technical program is by barcode scanning equipment, cloud server and mobile interchange technology, the Quality Control scope of this BT(batch testing) reagent of automatic acquisition, whether automatic decision Quality Control result is qualified, provide the mark that can continue to use and warn, make operation more intelligent easy, make layman also can be proper use of easily, avoid causing use problem because of maloperation and erroneous judgement, avoid measurement result to go wrong and cause potential actual bodily harm risk.

As preferably, the dosage of described external treatment terminal to patient's medication every day is monitored, the medication dose that external treatment terminal inputs according to user is compared, if with the medication dose of the previous day, to compare change larger, then give a warning information, remind dosage that patient takes whether correct, whether confirm through medical practitioner; If the dosage that takes shows that belong to medication errors, then patient's medication errors information is sent to described doctor's monitor terminal with wired or wireless communication modes by external treatment terminal through doctor's confirmation.Medication is safer, and the communication of patient and doctor is more unobstructed, avoids makeing mistakes, and can make adjustment in time, avoids the generation of risk or accident.

As preferably, actual for patient dosage and the prothrombin time value recorded present with amount effect curve by described external treatment terminal, the amount effect curve of dosage and prothrombin time value has two kinds of the mode options: the first pattern is, with the prothrombin time value recorded for y value, the last dosage before the detection time of this prothrombin time value is x value, carries out mapping regretional analysis; The second pattern is, with the prothrombin time value recorded for y value, 5 dosages of one day before the detection time of this prothrombin time value, two days, three days, four days and five days are respectively x value, five groups of linear regression analyses are carried out in mapping respectively, automatically the suite line selecting correlativity best presents, and also can artificially select to check any suite line by the enterprising line operate of button managing terminal in the outside; The regression equation of described amount effect curve is INR=k × D+b, INR is the actual prothrombin time value recorded, D is actual dosage, k and b is the parameter drawn by the amount effect curve regretional analysis of individual patient reality, can increase along with the data of accumulation every day and some changes occur, the rear a drug dosage suggestion of patient can be extrapolated thus, that is: D '=(INR ’ – b)/k, D ' is the rear a drug dosage of suggestion, INR ' is target prothrombin time value, and the rear a drug dosage of suggestion is presented in described external treatment terminal.Equation of linear regression realizes based on principle of least square method, and it finds the optimal function coupling of data by the quadratic sum of minimum error.Data volume is different, and the curve of recurrence will change.The anticoagulant effect of some oral anticoagulation is not manifest at once, as warfarin class medicine, after anticoagulant effect appears in 3 days, then can select the second pattern.For the medicine that effect of taking medicine comparatively fast presents, then can select the first pattern.According to the prothrombin time value recorded and target prothrombin time value, automatically the suggestion of rear a drug dosage is provided, dosage can be adjusted in time according to patient's actual conditions, the desired value that the actual prothrombin time value controlling patient provides closer to doctor, avoids the generation of risk or accident.

The regression equation of amount effect curve and the coefficient R of regretional analysis can show when consulting, and help doctor to carry out with medicament quantitative analysis and judgement.Coefficient R is the statistical indicator reflecting correlationship level of intimate between variable, in the technical program, coefficient R reflects the degree of correlation of the equation two groups of variablees (dosage, prothrombin time index) based on data regression, coefficient R evaluates an important indicator of prothrombin time and drug dose amount effect curve correlativity, R is between 0 ~ 1, more close to 1, correlativity is better.Coefficient R increases along with the data that accumulate every day and some changes occurs, and usually, data volume is larger, amount effect curve regression equation and R value more reliable.

Amount effect curve regression equation according to selecting carries out follow-up trend analysis, analyzes the stage being only limitted to take medicine.As selected the curve of prothrombin time before corresponding three days, the prediction after taking medicine for the last time three days can only be provided.

As preferably, if it is larger that the rear a drug dosage of suggestion and a front dosage compare change, then external treatment terminal gives a warning information, and the rear a drug dosage of suggestion, a front dosage and warning message are sent to described doctor's monitor terminal with wired or wireless communication modes, undertaken confirming or propose adjustment suggestion by medical practitioner.Further raising drug safety.

As preferably, when carrying out described amount effect curve mapping regretional analysis, only just can carry out this when dosage and prothrombin time value reach more than ten groups data and analyzing.Guarantee that amount effect curve can reflect the situation of patient truly, improve the accuracy analyzed and judge, thus provide the suggestion of medication accurately.

The invention has the beneficial effects as follows: by the mobile interchange system built, prothrombin time sense terminals and doctor's monitor terminal can carry out telecommunication, patient is in just can detect coagulation function, automatic analysis medicining condition, automatically medication dose adjustment suggestion is provided, simultaneously by testing result, medicining condition and the remote transmission such as suggestion and warning message are to doctor's monitor terminal, so that medical practitioner can understand Medication state and the health of be responsible for patient whenever and wherever possible in time, provide evaluation in time, suggestion or warning, avoid the trouble that client need usually travels to and fro between hospital and family, time saving and energy saving, avoid the generation of risk and accident.

Accompanying drawing explanation

Fig. 1 is a kind of system syndeton block diagram of the present invention's intelligence prothrombin time supervisory system.

1. prothrombin time sense terminals, 2. external treatment terminal, 3. doctor's monitor terminal in figure, 4. cloud server, 11. CPU (central processing unit), 12. temperature sensors, 13. barcode scanning terminal interfaces, 14. prothrombin time detecting units, 15. communication interfaces, 21.ARM controller, 22. display modules, 23. key-press modules, 24. communication modules, 25. alarm modules.

Embodiment

Below by embodiment, and by reference to the accompanying drawings, technical scheme of the present invention is described in further detail.

Embodiment: the intelligent prothrombin time supervisory system of the present embodiment, as shown in Figure 1, comprise prothrombin time sense terminals 1, external treatment terminal 2, doctor's monitor terminal 3 and cloud server 4, external treatment terminal 2, doctor's monitor terminal 3 are all connected with cloud server with wireless communication mode, prothrombin time sense terminals 1 and external treatment terminal 2 are two specific installations, and prothrombin time sense terminals 1 is connected with wire communication mode with external treatment terminal 2.Prothrombin time detecting unit 14, temperature sensor 12, barcode scanning terminal interface 13 and communication interface 15 that prothrombin time sense terminals 1 comprises CPU (central processing unit) 11 and is connected with CPU (central processing unit) 11 respectively.Prothrombin time detecting unit 14 is for gathering the reaction information in prothrombin time test-strips, obtain prothrombin time detection signal, temperature sensor 12 Real-time Collection environment temperature, be convenient to carry out temperature compensation to testing result, barcode scanning terminal interface 13 can connect barcode scanning instrument, is obtained the information such as patient number, name and medicament test-strips lot number, control liquid lot number by barcode scanning.Display module 22, key-press module 23, communication module 24 and alarm module 25 that external treatment terminal 2 comprises ARM controller 21 and is connected with ARM controller 21 respectively, communication module 24 comprise the wire communication module of carrying out wire communication with prothrombin time sense terminals 1 and and doctor's monitor terminal 3 carry out the wireless communication module of wireless telecommunications.The data that display module 22 transports for receiving ARM controller, display prothrombin time testing result, display safety information or warning message, show the suggestion of next dosage, display patient information, information about doctor and medication information; Key-press module 23 for editing patient name, numbering, medication information, monitoring information, test-strips lot number information and physician name, account, and flows to ARM controller.External treatment terminal 2 can use portable mobile equipment popular at present, as smart mobile phone or panel computer, and is aided with corresponding prothrombin time monitoring APP software and realizes.When external treatment terminal 2 employing has smart mobile phone or the panel computer of camera function, without the need to separately joining barcode scanning terminal.

In the present embodiment, prothrombin time sense terminals also can prepare control liquid, control liquid for judge prothrombin time sense terminals and test-strips work whether normal.The Quality Control scope of every BT(batch testing) bar has difference because of its reason such as raw materials for production, process, and every BT(batch testing) bar has its specific Quality Control scope.Quality Control scope carries out barcode scanning acquisition by barcode scanning terminal to test-strips, and when carrying out Quality Control and detecting, whether prothrombin time sense terminals energy automatic decision result is within the scope of Quality Control.If not in scope, then provide warning message.In addition, regular Quality Control can be arranged to remind, as one month; New use reagent lot Quality Control is reminded.

The method for supervising of above-mentioned intelligent prothrombin time supervisory system is:

By barcode scanning equipment, barcode scanning is carried out to test-strips lot number, by barcode scanning automatic acquisition test-strips lot number, then obtained working code and the parameter of this BT(batch testing) bar by external treatment terminal 2 and cloud server 4, realize automatic size adjusting function.

Test agent Quality Control detection method, step is as follows:

1) barcode scanning device scan test agent bar code, obtains test agent lot number information and flows to external treatment terminal 2;

2) external treatment terminal 2 and cloud server 4 carry out communication, the Quality Control scope of acquisition or synchronously this lot number test agent;

3) the Quality Control scope of external treatment terminal 2 On-board test reagent lot information and acquisition;

4) prothrombin time sense terminals 1 pair of test agent carries out Quality Control detection, and testing result is sent to external treatment terminal 2;

5) testing result and the Quality Control scope that obtains before are compared by external treatment terminal 2, provide the qualified or Quality Control result over range warning of Quality Control.

Prothrombin time sense terminals 1 gathers the information in prothrombin time test-strips by test-strips reaction signal treatment circuit, through the process of internal central processing unit, external treatment terminal 2 is flowed to wire communication mode, external treatment terminal 2 is according to the prothrombin time desired value preset, by analysis and process, whether the prothrombin time value that automatic decision actual acquisition arrives is in safe range, if deviation is larger, then give a warning information, collection result and judged result are sent to cloud server 4 with wireless communication mode by external treatment terminal 2 simultaneously, doctor's monitor terminal 3 is sent to again by cloud server 4, be convenient to doctor adjust patient's dosage in time and provide handling suggestion.

The dosage of external treatment terminal 2 pairs of patient's medications every day is monitored, the medication dose that external treatment terminal 2 inputs according to user is compared, if with the medication dose of the previous day, to compare change larger, then give a warning information, remind dosage that patient takes whether correct, whether confirm through medical practitioner; If the dosage that takes confirms without doctor, belong to medication errors, then patient's medication errors information is sent to doctor's monitor terminal 3 with wireless communication mode by external treatment terminal 2, is convenient to doctor and adjusts patient's dosage in time and provide handling suggestion.

The actual dosage of patient passes through the button typing in external treatment terminal 2 by patient, actual for patient dosage and the prothrombin time value recorded present with amount effect curve by external treatment terminal 2, during amount effect curve mapping regretional analysis, only just carry out this when dosage and prothrombin time value reach ten groups of data and analyze.The amount effect curve of dosage and prothrombin time value has two kinds of the mode options, if the medicine comparatively fast presented for effect, then selects the first pattern, otherwise selects the second pattern.The first pattern is, with the prothrombin time value recorded for y value, the last dosage before the detection time of this prothrombin time value is x value, carries out mapping regretional analysis, and in the outside manage terminal 2 LCDs on show amount effect curve.The second pattern is, with the prothrombin time value recorded for y value, 5 dosages of one day before the detection time of this prothrombin time value, two days, three days, four days and five days are respectively x value, five groups of linear regression analyses are carried out in mapping respectively, automatically the suite line selecting correlativity best presents, be presented in the LCDs of external treatment terminal 2, certainly operate on button and also can artificially select to check any suite line.The regression equation of amount effect curve is INR=k × D+b, INR is the actual prothrombin time value recorded, D is dosage, k and b is the parameter drawn by the amount effect curve regretional analysis of individual patient reality, can increase along with the data of accumulation every day and some changes occur, the rear a drug dosage suggestion of patient can be extrapolated thus, that is: D '=(INR ’ – b)/k, D ' is the rear a drug dosage of suggestion, INR ' is target prothrombin time value, and the rear a drug dosage of suggestion is presented in the LCDs of external treatment terminal 2.If it is larger that the rear a drug dosage of suggestion and a front dosage compare change, then external treatment terminal 2 gives a warning information, and the rear a drug dosage of suggestion, a front dosage and warning message are sent to doctor's monitor terminal 3 with wireless communication mode by cloud server, undertaken confirming or proposing amending advice by medical practitioner.

For the patient that INR norm controlling is good, external treatment terminal 2 provides the feedback opinion of drug safety automatically; For the patient that INR norm controlling is poor, external treatment terminal 2 directly sends data to physician, and feeds back the unsafe information warning of medication to patient, reminds patient to seek medical advice as early as possible.

The workflow of intelligence prothrombin time supervisory system:

1, prothrombin time sense terminals and external treatment terminal is started.

2, manage in terminal in the outside correct time or lock in time are set, carry out duty, optimum configurations etc.

3, patient information is obtained by barcode scanning terminal or operation is manual on button inputs patient information.

4, the data management software in external treatment terminal is opened, input medication information.

5, manage in the outside and terminal insert chip or obtain the information such as test-strips lot number, working strategy by barcode scanning terminal.

6, in prothrombin time sense terminals, test-strips is inserted.

7, collection capillary blood or venous blood carry out application of sample test, obtain test result.

8, the data management software in external treatment terminal is opened, check medication information and detecting information whether correct, carry out analyzing, process and judging, correlated results teletransmission to cloud server, sent to doctor's monitor terminal of supervisor doctor again by cloud server, physician also can by the long-range transmission advisory information of cloud server to external treatment terminal.

9, detection case can be consulted at any time by the data management software in external treatment terminal, and have the analytic functions such as performance graph.

In addition, external treatment terminal software system of the present invention comprises Quality Control and reminds, and reminding user, when system has potential risk, needs to carry out Quality Control, guarantees the accuracy of supervisory system.Quality Control reminds logic to comprise:

One, when new system just uses

External treatment terminal obtains prothrombin time sense terminals identifier information, when without the information of storage, thinks that new system uses, and provides Quality Control and reminds.

Two, system cycle Quality Control

External treatment terminal software acquiescence is reminded once January, and user also can be arranged.

When three, using the test agent of new lot

External treatment terminal can store the lot number information of last test result, and when using new lot number, barcode scanning equipment can obtain lot number information, and when inconsistent with the lot number of last test result, the Quality Control providing the test agent using new lot is reminded.

Four, when supervisory system a period of time does not use

External treatment terminal can store the test duration of last test result, when setup test next time, when prothrombin time sense terminals inserts test agent, prothrombin time sense terminals send information to external treatment terminal, external treatment terminal can check the time, as exceeded preset range (as 1 month) with the lead time of last test result, then providing not use for a long time needs Quality Control to remind.

Claims (10)

1. an intelligent prothrombin time supervisory system, is characterized in that comprising prothrombin time sense terminals (1), external treatment terminal (2) and doctor's monitor terminal (3);

Prothrombin time sense terminals (1): for detecting prothrombin time, and testing result is sent to described external treatment terminal (2) with wired or wireless communication modes;

External treatment terminal (2): the prothrombin time testing result sent with wired or wireless communication modes reception prothrombin time sense terminals (1), and carry out treatment and analysis, make the judgement whether in safe range, display safety information or the information that gives a warning, provide amount effect curve and regression equation, and above-mentioned information is sent to the doctor's monitor terminal (3) be positioned at described in far-end with wired or wireless communication modes, provide Dynamic Graph directly perceived and data reference to doctor;

Doctor's monitor terminal (3): carry out wired or wireless communication with described external treatment terminal (2), for receiving the information that external treatment terminal (2) sends, also can edit also move instruction to described external treatment terminal (2).

2. intelligent prothrombin time supervisory system according to claim 1, it is characterized in that comprising cloud server (4): for both carrying out wired or wireless communication with described external treatment terminal (2), wired or wireless communication is carried out again with described doctor's monitor terminal (3), ensure the data syn-chronization of external treatment terminal (2) and doctor's monitor terminal (3), cloud server (4) itself can also automatically externally processing terminal (2) and doctor's monitor terminal (3) push related data.

3. intelligent prothrombin time supervisory system according to claim 1 and 2, is characterized in that prothrombin time detecting unit (14), temperature sensor (12), barcode scanning terminal interface (13) and communication interface (15) that described prothrombin time sense terminals (1) comprises CPU (central processing unit) (11) and is connected with CPU (central processing unit) (11) respectively;

CPU (central processing unit) (11): the prothrombin time detection signal for sending here prothrombin time detecting unit (14) processes, and according to the actual environment temperature that temperature sensor (12) is sent here, temperature compensation is carried out to prothrombin time detection signal, then prothrombin time testing result is calculated by test-strips parameter information, obtain patient information and test-strips information by barcode scanning terminal interface (13), connecting communication interface (15) is to carry out data communication with described external treatment terminal (2);

Prothrombin time detecting unit (14): for gathering the reaction information in prothrombin time test-strips, obtains prothrombin time detection signal and flows to described CPU (central processing unit) (11);

Temperature sensor (12): Real-time Collection environment temperature also flows to described CPU (central processing unit) (11), is convenient to CPU (central processing unit) (11) and carries out temperature compensation to prothrombin time testing result;

Barcode scanning terminal interface (13): for connecting barcode scanning instrument, described CPU (central processing unit) (11) is flowed to by barcode scanning acquisition patient number and name, by barcode scanning automatic acquisition test-strips lot number and the parameter information obtaining this lot number from high in the clouds flows to described CPU (central processing unit) (11), realize automatic size adjusting;

Communication interface (15): for realizing the data communication of CPU (central processing unit) (11) and described external treatment terminal (2);

Display module (22), key-press module (23), communication module (24) and alarm module (25) that described external treatment terminal (2) comprises ARM controller (21) and is connected with ARM controller (21) respectively;

ARM controller (21): carry out communication with described prothrombin time sense terminals (1), treatment and analysis is carried out to the prothrombin time testing result received, make the judgement whether in safe range, display safety information or the information that gives a warning, provide amount effect curve and regression equation, and above-mentioned information is passed through

Communication module (24) sends, and provides Dynamic Graph directly perceived and data reference to doctor;

Display module (22): for receiving the data that ARM controller (21) transports, display prothrombin time testing result, display safety information or warning message, show the suggestion of next dosage, display patient

Information, information about doctor and medication information;

Key-press module (23): for editing patient name, numbering, medication information, monitoring information, test-strips lot number information and physician name, account, and flow to ARM controller (21);

Communication module (24): be connected with ARM controller (21), realizes the data communication of ARM controller (21) and described doctor's monitor terminal (3) or cloud server (4);

Alarm module (25): when ARM controller (21) judges that the prothrombin time testing result received exceedes safe range, start alarm module (25), give a warning information.

4. intelligent prothrombin time supervisory system according to claim 1 and 2, is characterized in that described prothrombin time sense terminals (1) and external treatment terminal (2) belong to two modules or two specific installations of same equipment.

5. the method for supervising of an intelligent prothrombin time supervisory system as claimed in claim 1, it is characterized in that described prothrombin time sense terminals (1) gathers the information in prothrombin time test-strips, and flow to described external treatment terminal (2) with wired or wireless communication modes, external treatment terminal (2) is according to the prothrombin time desired value preset, by analysis and process, whether the prothrombin time value that automatic decision actual acquisition arrives is in safe range, if deviation is larger, then give a warning information, collection result and judged result are sent to described doctor's monitor terminal (3) with wired or wireless communication modes by external treatment terminal (2) simultaneously.

6. method for supervising according to claim 5, is characterized in that described prothrombin time sense terminals (1) is provided with barcode scanning terminal interface (13); Described method for supervising comprises: carry out barcode scanning by connecting barcode scanning equipment at described barcode scanning terminal interface (13) to test-strips lot number, by barcode scanning automatic acquisition test-strips lot number, obtained working code and the parameter of this BT(batch testing) bar again by the communication of described external treatment terminal and described cloud server (4), realize automatic size adjusting function.

7. method for supervising according to claim 6, it is characterized in that comprising test agent Quality Control detection method, step is as follows:

Described barcode scanning device scan test agent bar code, obtains test agent lot number information and flows to described external treatment terminal (2);

External treatment terminal (2) and described cloud server (4) carry out communication, the Quality Control scope of acquisition or synchronously this lot number test agent;

The Quality Control scope of external treatment terminal (2) On-board test reagent lot information and acquisition;

Described prothrombin time sense terminals (1) carries out Quality Control detection to test agent, and testing result is sent to external treatment terminal (2);

Testing result and the Quality Control scope that obtains before are compared by external treatment terminal (2), provide the qualified or Quality Control result over range warning of Quality Control.

8. method for supervising according to claim 5, it is characterized in that the described dosage of external treatment terminal (2) to patient's medication every day is monitored, the medication dose that external treatment terminal (2) inputs according to user is compared, if with the medication dose of the previous day, to compare change larger, then give a warning information, remind dosage that patient takes whether correct, whether confirm through medical practitioner; If the dosage that takes confirms without doctor, belong to medication errors, then patient's medication errors information is sent to described doctor's monitor terminal (3) with wired or wireless communication modes by external treatment terminal (2).

9. the method for supervising according to claim 5 or 6 or 7 or 8, it is characterized in that actual for patient dosage and the prothrombin time value recorded present with amount effect curve by described external treatment terminal (2), the amount effect curve of dosage and prothrombin time value has two kinds of the mode options: the first pattern is, with the prothrombin time value recorded for y value, the last dosage before the detection time of this prothrombin time value is x value, carries out mapping regretional analysis, the second pattern is, with the prothrombin time value recorded for y value, 5 dosages of one day before the detection time of this prothrombin time value, two days, three days, four days and five days are respectively x value, five groups of linear regression analyses are carried out in mapping respectively, automatically the suite line selecting correlativity best presents, and also can artificially select to check any suite line by the enterprising line operate of button managing terminal (2) in the outside, the regression equation of described amount effect curve is INR=k × D+b, INR is the actual prothrombin time value recorded, D is actual dosage, k and b is the parameter drawn by the amount effect curve regretional analysis of individual patient reality, can increase along with the data of accumulation every day and some changes occur, the rear a drug dosage suggestion of patient can be extrapolated thus, that is: D '=(INR ’ – b)/k, D ' is the rear a drug dosage of suggestion, INR ' is target prothrombin time value, the rear a drug dosage of suggestion is presented in described external treatment terminal (2).

10. method for supervising according to claim 9, it is characterized in that if the rear a drug dosage of advising and a front dosage to compare change larger, then external treatment terminal (2) gives a warning information, and the rear a drug dosage of suggestion, a front dosage and warning message are sent to described doctor's monitor terminal (3) with wired or wireless communication modes, undertaken confirming or propose adjustment suggestion by medical practitioner; When carrying out described amount effect curve mapping regretional analysis, only just can carry out this when dosage and prothrombin time value reach more than ten groups data and analyzing.