技术领域technical field
医学装置，更具体的说是血栓切除术导管和方法。Medical devices, more particularly thrombectomy catheters and methods.
背景技术Background technique
血栓切除术是一种用来从例如动脉或者静脉的血管去除血块(血栓)的医疗方法。如果血栓不去除，会堵塞血流。实施血栓切除术的一个技术是使用具有喷注腔和抽吸腔的导管，所述喷注腔用来击碎血栓，所述抽吸腔用来真空吸收血栓和栓子。Thrombectomy is a medical procedure used to remove a blood clot (thrombus) from a blood vessel, such as an artery or vein. If the clot is not removed, it can block blood flow. One technique for performing thrombectomy is to use a catheter with an infusion lumen to break up the thrombus and an aspiration lumen to vacuum the thrombus and emboli.
在一些例子中，使用复杂的导管系统来执行血栓切除术操作，配置所述系统来提供多股高压射流，所述射流可以是以10,000psi或者更大的压力供应的盐水。相应地，供应高压流体需要高压泵。对于其他医疗操作来说，高压血栓切除术操作(例如，药物和造影注入等)的泵实用性不强。In some instances, thrombectomy procedures are performed using complex catheter systems configured to deliver multiple high pressure jets, which may be saline supplied at a pressure of 10,000 psi or greater. Accordingly, supplying high pressure fluid requires a high pressure pump. Pumps for high pressure thrombectomy procedures (eg, drug and contrast infusion, etc.) are less practical for other medical procedures.
另外，用在这些操作中的血栓切除术导管结构上具有用来分配从血管去除血栓的流体射流的复杂歧管、流体射流排出特征等。此外，为了可以输送和分配高压流体，用坚固耐用的材料来构造这些导管。相应地，这些血栓切除术系统昂贵、需要多步骤的制造技术，并且进一步需要专门的操作设备(例如，如上文所述的高压泵)。Additionally, the thrombectomy catheters used in these procedures are structurally equipped with complex manifolds, fluid jet discharge features, etc. to distribute the fluid jets that remove the thrombus from the blood vessel. In addition, these conduits are constructed of strong and durable materials in order to allow the delivery and distribution of high pressure fluids. Accordingly, these thrombectomy systems are expensive, require multi-step manufacturing techniques, and further require specialized operating equipment (eg, high pressure pumps as described above).
发明内容Contents of the invention
本公开的一个例子包括导管本体，所述导管本体从导管近端部分延伸到导管远端部分并且包括导管中间部分，所述导管本体包括沿着其延伸的抽吸腔和灌注腔，其中所述抽吸腔包括开口在所述导管本体远端的抽吸孔。An example of the present disclosure includes a catheter body extending from a catheter proximal portion to a catheter distal portion and including a catheter intermediate portion, the catheter body including an aspiration lumen and an irrigation lumen extending therealong, wherein the The suction lumen includes a suction hole opening at the distal end of the catheter body.
在本公开的另一个例子中，所述导管本体具有整体均匀的横截面轮廓，并且具有沿其长度变化的多个硬度值，使得相互比较下，所述导管近端部分具有相对高的硬度值，而所述导管远端部分具有相对低的硬度值。In another example of the present disclosure, the catheter body has an overall uniform cross-sectional profile and has a plurality of hardness values varying along its length such that the proximal portion of the catheter has a relatively high hardness value compared to each other. , while the catheter distal portion has a relatively low hardness value.
还是在本公开的另一个例子中，所述灌注腔沿所述导管本体朝着所述远端部分延伸，并且包括配置用来引导流体射流从所述导管本体的纵轴径向射出的单灌注孔。In yet another example of the present disclosure, the irrigation lumen extends along the catheter body toward the distal portion and includes a single irrigation chamber configured to direct fluid jets radially out from the longitudinal axis of the catheter body. hole.
还是在本公开的另一个例子中，导管本体的远端包括抽吸孔远端元件，所述抽吸孔远端元件包括近端部分和远端部分，所述近端部分从所述导管本体的远端开始延伸且具有与所述抽吸腔尺寸类似的开口，所述远端部分具有比所述抽吸腔更宽的开口。In yet another example of the present disclosure, the distal end of the catheter body includes a suction bore distal element comprising a proximal portion and a distal portion, the proximal portion extending from the catheter body. The distal end extends from and has an opening similar in size to the suction lumen, the distal portion having a wider opening than the suction lumen.
在一个特定的例子中公开了一种血栓切除术导管，包括从导管近端部分延伸到导管远端部分的导管本体；从所述导管近端部分朝着所述导管远端部分穿过所述导管本体延伸的抽吸腔，所述抽吸腔在所述导管远端部分附近包括抽吸孔，其中所述导管本体的远端包括抽吸孔远端元件，所述抽吸孔远端元件包括近端部分和远端部分，所述近端部分从所述导管本体的远端开始延伸且具有与所述抽吸腔尺寸类似的开口，所述远端部分具有比所述抽吸腔更宽的开口；以及沿所述导管本体朝着远端部分延伸的灌注腔，所述灌注腔具有位于所述导管本体侧壁的单灌注孔，所述单灌注孔配置用来引导流体射流从所述导管本体的纵轴径向射出。In a particular example a thrombectomy catheter is disclosed comprising a catheter body extending from a catheter proximal portion to a catheter distal portion; a suction lumen extending from the catheter body, the suction lumen including a suction hole near a distal portion of the catheter, wherein the distal end of the catheter body includes a suction hole distal element, the suction hole distal element including a proximal portion extending from the distal end of the catheter body and having an opening similar in size to the suction lumen, and a distal portion having a diameter greater than that of the suction lumen a wide opening; and a perfusion lumen extending along the catheter body toward the distal portion, the perfusion lumen having a single perfusion hole in the sidewall of the catheter body configured to direct fluid jets from the catheter body The longitudinal axis of the catheter body projects radially.
在另一个特定的例子中公开了一种血栓切除术导管，包括导管本体，所述导管本体从导管近端部分延伸到导管远端部分并且包括导管中间部分，导管本体包括沿着其延伸的抽吸腔和灌注腔，所述导管本体具有整体均匀的横截面轮廓，并且具有沿其长度变化的多个硬度值，使得相互比较下，所述导管近端部分具有相对高的硬度值，而所述导管远端部分具有相对低的硬度值；其中所述抽吸腔包括开口在所述导管本体远端的抽吸孔；以及其中所述灌注腔沿所述导管本体朝着所述远端部分延伸，并且包括配置用来引导流体射流从所述导管本体的纵轴径向射出的单灌注孔。In another specific example, a thrombectomy catheter is disclosed that includes a catheter body that extends from a catheter proximal portion to a catheter distal portion and includes a catheter intermediate portion that includes a drawer extending therealong. suction lumen and irrigation lumen, the catheter body has an overall uniform cross-sectional profile, and has a plurality of hardness values varying along its length, so that in comparison with each other, the proximal portion of the catheter has a relatively high hardness value, while the The distal portion of the catheter has a relatively low durometer value; wherein the suction lumen comprises a suction hole opening at the distal end of the catheter body; and wherein the perfusion lumen extends along the catheter body toward the distal portion extending, and including a single irrigation hole configured to direct a fluid jet radially out from the longitudinal axis of the catheter body.
在另一个特定的例子中公开了一种血栓切除术导管，包括导管本体，所述导管本体从导管近端部分延伸到导管远端部分并且包括导管中间部分，其中相互比较之下，所述导管近端部分具有相对高的硬度值，而所述导管远端部分具有相对低的硬度值；所述导管本体包括抽吸腔，所述抽吸腔从所述导管近端部分朝着所述导管远端部分延伸穿过所述导管本体，所述抽吸腔包括开口在所述导管本体远端的抽吸孔，其中所述抽吸孔在所述导管本体的远端没有结构上的障碍物，并且其中所述导管本体的远端包括抽吸孔远端元件，所述抽吸孔远端元件包括近端部分和远端部分，所述近端部分从所述导管本体的远端开始延伸且具有与抽吸腔尺寸类似的开口，所述远端部分具有比抽吸腔更宽的开口；所述导管本体进一步包括灌注腔，所述灌注腔沿所述导管本体朝着所述远端部分延伸，具有穿过所述导管本体延伸的灌注孔，所述灌注孔用来引导流体射流从所述导管本体射出。In another specific example is disclosed a thrombectomy catheter comprising a catheter body extending from a catheter proximal portion to a catheter distal portion and including a catheter intermediate portion, wherein the catheters are a proximal portion has a relatively high durometer value and the catheter distal portion has a relatively low durometer value; the catheter body includes a suction lumen extending from the catheter proximal portion toward the catheter a distal portion extends through the catheter body, the suction lumen includes a suction hole opening at the distal end of the catheter body, wherein the suction hole is free of structural obstructions at the distal end of the catheter body , and wherein the distal end of the catheter body comprises a suction hole distal element comprising a proximal portion and a distal portion, the proximal portion extending from the distal end of the catheter body and having an opening similar in size to the suction lumen, the distal portion has a wider opening than the suction lumen; the catheter body further includes a perfusion lumen along the catheter body toward the distal end A portion extends with an irrigation hole extending through the catheter body for directing a fluid jet from the catheter body.
在另一个特定的例子中公开了一种血栓切除术导管，包括导管本体，所述导管本体从导管近端部分延伸到导管远端部分并且包括导管中间部分，所述导管本体包括沿着其延伸的抽吸腔和灌注腔，所述导管本体具有整体均匀的横截面轮廓，并且其硬度具有沿其长度变化的多个硬度值，使得相互比较之下，导管近端部分具有相对高的硬度值，而导管远端部分具有相对低的硬度值；其中所述抽吸腔从导管近端部分朝着导管远端部分延伸穿过所述导管本体，所述抽吸腔包括开口在所述导管本体远端的抽吸孔，其中所述导管本体的远端包括抽吸孔远端元件，所述抽吸孔远端元件包括近端部分和远端部分，所述近端部分从所述导管本体的远端开始延伸，其中所述远端部分具有比近端部分更加大的横截面；并且其中所述灌注腔沿所述导管本体朝着所述远端部分延伸，具有穿过所述导管本体延伸的灌注孔，所述灌注孔用来引导流体射流从所述导管本体射出。In another specific example, a thrombectomy catheter is disclosed that includes a catheter body that extends from a catheter proximal end portion to a catheter distal end portion and includes a catheter intermediate portion that includes a catheter body extending therealong. The catheter body has an overall uniform cross-sectional profile and its hardness has multiple hardness values varying along its length such that the proximal portion of the catheter has a relatively high hardness value in comparison with each other , while the catheter distal portion has a relatively low hardness value; wherein the suction lumen extends through the catheter body from the catheter proximal portion toward the catheter distal portion, the suction lumen comprising an opening in the catheter body a suction hole at a distal end, wherein the distal end of the catheter body comprises a suction hole distal element comprising a proximal portion and a distal portion, the proximal portion extending from the catheter body and wherein the perfusion lumen extends along the catheter body toward the distal portion, with a cross-section through the catheter body An extended irrigation hole for directing a fluid jet from the catheter body.
在另一个特定的例子中公开了一种血栓切除术导管，包括导管本体，所述导管本体从导管近端部分延伸到导管远端部分并且包括导管中间部分，所述导管本体包括沿着其延伸的抽吸腔和灌注腔，所述导管本体具有整体均匀的横剖面轮廓，并且其硬度具有沿其长度变化的多个硬度值，使得相互比较之下，导管近端部分具有相对高的硬度值，而导管远端部分具有相对低的硬度值；其中所述抽吸腔从所述导管近端部分朝着所述导管远端部分延伸穿过所述导管本体，所述抽吸腔包括开口在所述导管本体远端的抽吸孔；并且其中所述灌注腔沿所述导管本体朝着所述远端部分延伸，具有穿过所述导管本体延伸的灌注孔，所述灌注孔用来引导流体射流从所述导管本体射出。In another specific example, a thrombectomy catheter is disclosed that includes a catheter body that extends from a catheter proximal end portion to a catheter distal end portion and includes a catheter intermediate portion that includes a catheter body extending therealong. The suction lumen and irrigation lumen of the catheter body have an overall uniform cross-sectional profile, and its hardness has a plurality of hardness values that vary along its length, so that the proximal portion of the catheter has a relatively high hardness value in comparison with each other , while the distal portion of the catheter has a relatively low hardness value; wherein the suction lumen extends through the catheter body from the proximal portion of the catheter towards the distal portion of the catheter, the suction lumen comprising an opening at a suction hole at the distal end of the catheter body; and wherein the perfusion lumen extends along the catheter body toward the distal portion, having a perfusion hole extending through the catheter body for guiding A fluid jet exits the catheter body.
在另一个特定的例子中公开了一种血栓切除术导管，包括:包括抽吸腔的导管本体，所述抽吸腔穿过所述导管本体延伸并且在抽吸孔处开口；灌注本体，所述灌注本体包括延伸到灌注孔的流体输送腔，所述灌注本体穿过所述抽吸腔延伸；以及扩张元件，所述扩张元件连接到所述灌注本体的远端并且位于所述灌注孔的远侧。In another specific example, a thrombectomy catheter is disclosed, comprising: a catheter body including a suction lumen extending through the catheter body and opening at a suction hole; a perfusion body, the The perfusion body includes a fluid delivery lumen extending to a perfusion hole through which the perfusion body extends; and an expansion element connected to a distal end of the perfusion body and positioned at the perfusion hole far side.
在另一个特定的例子中公开了一种血栓切除术系统，包括：流体输送装置；抽吸器；以及血栓切除术导管，所述血栓切除术导管具有与流体输送装置连接的第一端口以及与抽吸器连接的第二端口，其中血栓切除术导管包括；导管本体，所述导管本体从导管近端部分延伸到导管远端部分并且包括导管中间部分，其中相互比较之下，导管近端部分具有相对高的硬度值，而导管远端部分具有相对低的硬度值；抽吸腔，所述抽吸腔从所述导管近端部分朝着所述导管远端部分延伸穿过所述导管本体，所述抽吸腔包括开口在所述导管本体远端的抽吸孔，其中所述导管本体的远端包括抽吸孔远端元件，所述抽吸孔远端元件包括近端部分和远端部分，所述近端部分从所述导管本体的远端开始延伸，具有与抽吸腔大小类似的开口，而远端部分具有比抽吸腔更宽的开口；所述导管本体进一步包括灌注腔，所述灌注腔沿所述导管本体朝着所述远端部分延伸，具有穿过所述导管本体延伸的灌注孔，所述灌注孔用来引导流体射流从所述导管本体射出。In another specific example, a thrombectomy system is disclosed that includes: a fluid delivery device; an aspirator; and a thrombectomy catheter having a first port connected to the fluid delivery device and a A second port to which the aspirator is connected, wherein the thrombectomy catheter comprises; a catheter body extending from a catheter proximal portion to a catheter distal portion and including a catheter intermediate portion, wherein the catheter proximal portion is having a relatively high durometer value while the catheter distal portion has a relatively low durometer value; a suction lumen extending through the catheter body from the catheter proximal portion towards the catheter distal portion , the suction cavity includes a suction hole opening at the distal end of the catheter body, wherein the distal end of the catheter body includes a suction hole distal element, and the suction hole distal element includes a proximal portion and a distal An end portion, the proximal portion extending from the distal end of the catheter body, has an opening similar in size to the suction lumen, while the distal portion has an opening wider than the suction lumen; the catheter body further includes an irrigation A lumen extending along the catheter body toward the distal portion has an irrigation hole extending through the catheter body for directing a fluid jet from the catheter body.
在另一个特定的例子中公开了前面几段中的血栓切除术系统，其中所述抽吸器包括真空源，所述真空源包括通过旋塞阀式歧管组成一套的多支注射器。In another specific example the thrombectomy system of the preceding paragraphs is disclosed wherein the aspirator includes a vacuum source comprising a plurality of syringes grouped together through a stopcock-type manifold.
在另一个特定的例子中公开了前面任一段中的血栓切除术系统，其中所述单灌注孔远离所述抽吸孔朝向近侧凹入。In another specific example the thrombectomy system of any of the preceding paragraphs is disclosed, wherein the single perfusion port is recessed proximally away from the aspiration port.
在另一个特定的例子中公开了前面任一段中的血栓切除术导管，其中所述导管本体的远端包括抽吸孔远端元件，所述抽吸孔远端元件包括近端部分和远端部分，所述近端部分从所述导管本体的远端开始延伸且具有与所述抽吸腔尺寸类似的开口，所述远端部分具有比所述抽吸腔更宽的开口。In another specific example the thrombectomy catheter of any of the preceding paragraphs is disclosed wherein the distal end of the catheter body comprises a suction aperture distal element comprising a proximal portion and a distal end The proximal portion extends from the distal end of the catheter body and has an opening similar in size to the suction lumen, and the distal portion has an opening wider than the suction lumen.
仍然是在另一个特定的例子中公开了一种喷注器系统包括：外壳，所述外壳保持住高压泵、低压泵和抽吸模块；其中血栓切除术导管配置成连接到高压泵或者低压泵；所述高压泵进一步包括能够以5000psi到10,000psi之间的压力输送流体的单活塞泵；以及所述低压泵进一步包括能够以500psi到1500psi之间的压力输送流体的多活塞泵。In still another specific example, an injector system is disclosed comprising: a housing holding a high pressure pump, a low pressure pump, and an aspiration module; wherein the thrombectomy catheter is configured to connect to either the high pressure pump or the low pressure pump the high pressure pump further comprises a single piston pump capable of delivering fluid at a pressure between 5000 psi and 10,000 psi; and the low pressure pump further comprises a multi piston pump capable of delivering fluid at a pressure of between 500 psi and 1500 psi.
在另一个特定的例子中公开的前段喷注器系统，其中将所述高压泵和所述低压泵配置成彼此独立运作。In another specific example the front injector system is disclosed wherein said high pressure pump and said low pressure pump are configured to operate independently of each other.
这些例子可以以任意交换或者结合的方式进行组合。本发明内容所提供的仅是本专利申请技术方案的概览。不打算提供本发明的排他解释或者详尽解释。在详细的说明书中将提供关于本专利申请的进一步的信息。These examples can be combined in any exchange or combination. The summary of the present invention is only an overview of the technical solutions of this patent application. It is not intended to provide an exclusive or exhaustive explanation of the invention. Further information on this patent application will be provided in the detailed description.
附图说明Description of drawings
附图未必按比例做出，在不同的视图中相同的数字描述类似的元件。具有不同字母后缀的相同的数字表示类似元件的不同例子。通常所做附图是作为例子而非限制，本文件中还讨论了各种实施例。The drawings are not necessarily to scale, and like numerals describe similar elements in the different views. The same numbers with different letter suffixes indicate different examples of similar elements. The drawings are generally made by way of example and not limitation, and various embodiments are also discussed in this document.
图1示出了根据本公开一个实施例所述的血栓切除术导管。Figure 1 illustrates a thrombectomy catheter according to one embodiment of the present disclosure.
图2示出了图1血栓切除术导管的横截面。Figure 2 shows a cross-section of the thrombectomy catheter of Figure 1 .
图3示出了图1血栓切除术导管远端部分的立体图。Figure 3 shows a perspective view of the distal portion of the thrombectomy catheter of Figure 1 .
图4示出了图1血栓切除术导管远端部分的侧视图。Figure 4 shows a side view of the distal portion of the thrombectomy catheter of Figure 1 .
图5示出了抽吸孔元件的端部视图。Figure 5 shows an end view of the suction orifice element.
图6A示出了血管内的血栓切除术导管100的侧视图，通过广口边缘与血栓环形结合，血栓卡在广口远端元件中。FIG. 6A shows a side view of an endovascular thrombectomy catheter 100 with a wide mouth edge annularly engaged with a thrombus that is lodged in the wide mouth distal element.
图6B示出了图6A的血栓切除术导管的侧视图，血栓坍缩在广口远端元件内并且朝着近端导管端移动。6B shows a side view of the thrombectomy catheter of FIG. 6A with a thrombus collapsed within the wide-bore distal element and moving toward the proximal catheter end.
图6C示出了图6B的血栓切除术导管的侧视图，血栓坍缩在更小直径的导管部分并且朝着近端导管端移动。6C shows a side view of the thrombectomy catheter of FIG. 6B with a thrombus collapsing in the smaller diameter catheter portion and moving toward the proximal catheter end.
图7示出了根据本公开一个实施例所述的血栓切除术导管的横截面。Figure 7 shows a cross-section of a thrombectomy catheter according to one embodiment of the present disclosure.
图8示出了根据本公开一个实施例所述的血栓切除术导管的远端。Figure 8 illustrates the distal end of a thrombectomy catheter according to one embodiment of the present disclosure.
图9A示出了根据本公开一个实施例所述的部分血栓切除术系统。Figure 9A illustrates a partial thrombectomy system according to one embodiment of the present disclosure.
图9B示出了根据本公开一个实施例所述的喷注器系统。Figure 9B illustrates an injector system according to one embodiment of the present disclosure.
图10示出了根据本公开一个实施例所示的真空源的立体图。Figure 10 shows a perspective view of a vacuum source according to one embodiment of the disclosure.
图11示出了图10真空源的主视图。FIG. 11 shows a front view of the vacuum source of FIG. 10 .
图12A示出了根据本公开一个实施例所述的喷注器系统一个例子的示意图。Figure 12A shows a schematic diagram of an example of an injector system according to an embodiment of the present disclosure.
图12B示出了根据本公开一个实施例所述的喷注器系统一个例子的示意图。Figure 12B shows a schematic diagram of an example of an injector system according to an embodiment of the present disclosure.
图13A示出了根据本公开一个实施例所述的血栓切除术导管的侧视图。Figure 13A shows a side view of a thrombectomy catheter according to one embodiment of the present disclosure.
图13B示出的是与图13A中所示血栓切除术导管一起使用的扩张元件的细节横剖视图。Figure 13B shows a detailed cross-sectional view of an expansion element for use with the thrombectomy catheter shown in Figure 13A.
图14示出的是在抽吸孔具有堵塞物的图13A的血栓切除术导管的细节图。14 shows a detail view of the thrombectomy catheter of FIG. 13A with a blockage at the aspiration hole.
图15示出的是图14的血栓切除术导管的细节侧视图，其中堵塞物被机械驱动进抽吸腔。FIG. 15 shows a detailed side view of the thrombectomy catheter of FIG. 14 with an obstruction mechanically driven into the aspiration lumen.
具体实施方式Detailed ways
图1示出了根据本发明一个实施例的血栓切除术导管100的侧视图。正如下文所要详细描述的，为了从血管去除血栓，血栓切除术导管100配置成在远端生成加压流体。另外，为了利用加压流体去除血栓，在血栓切除术导管100的远端设置了真空源(抽吸)。血栓切除术导管100一般包括从导管近端部分104延伸到导管远端部分108的导管本体102。导管的中间部分106在导管的近端部分104和远端部分108之间延伸。在一个实施例中，与近端部分104相比，导管本体102的远端部分108更为柔软，这种设置有助于导管本体102在对象脉管系统穿行过程中的导航。导管本体102包括抽吸腔110和灌注腔111，所述抽吸腔110和灌注腔111沿导管本体102从导管近端部分104延伸到导管远端部分108。Figure 1 shows a side view of a thrombectomy catheter 100 according to one embodiment of the present invention. As will be described in detail below, in order to remove a thrombus from a blood vessel, the thrombectomy catheter 100 is configured to generate a pressurized fluid at the distal end. Additionally, a vacuum source (suction) is provided at the distal end of the thrombectomy catheter 100 in order to remove the thrombus using pressurized fluid. Thrombectomy catheter 100 generally includes a catheter body 102 extending from a catheter proximal portion 104 to a catheter distal portion 108 . An intermediate portion 106 of the catheter extends between a proximal portion 104 and a distal portion 108 of the catheter. In one embodiment, the distal portion 108 of the catheter body 102 is more flexible than the proximal portion 104, which facilitates navigation of the catheter body 102 during passage through the subject's vasculature. Catheter body 102 includes aspiration lumen 110 and irrigation lumen 111 that extend along catheter body 102 from catheter proximal portion 104 to catheter distal portion 108 .
参考图1，正如下文所要讨论的，灌注腔111连接到侧端口122，所述侧端口122连接到流体输送装置。灌注腔111将压力下的流体输送到导管的远端部分108，例如，输送到在血栓切除术手术中使用的射流口。为了与血栓流体动力接合，射流口产生大约1500psi压力的流体射流，但是也可以取其他的压力值。抽吸腔110连接到中心端口，所述中心端口能够连接到真空装置。Referring to FIG. 1 , as discussed below, the perfusion lumen 111 is connected to a side port 122 that is connected to a fluid delivery device. The perfusion lumen 111 delivers fluid under pressure to the catheter's distal portion 108, eg, to a jet port used during a thrombectomy procedure. In order to hydrodynamically engage the thrombus, the jet port generates a fluid jet at a pressure of approximately 1500 psi, although other pressure values are possible. The suction lumen 110 is connected to a central port which can be connected to a vacuum.
在使用过程中，血栓切除术导管100插入到例如静脉或者动脉的血管中，并且通过灌注腔111将流体输送到导管远端部分108。流体以一股或者多股射流的形式输送，并且通过流体动力击碎血管内的血栓(例如，通过集中的流体压力，流体速度以及流体流量)。例如，流体冲击血栓，并且通过该种结合机械地浸软血栓。正如下文所要讨论的，通过加宽的抽吸孔远端元件114，抽吸腔110吸收被击碎的血栓，并且通过端口120将其输送到废物单元，例如收集袋、药水瓶、滑槽等等。During use, the thrombectomy catheter 100 is inserted into a blood vessel, such as a vein or an artery, and fluid is delivered to the catheter distal portion 108 through the perfusion lumen 111 . The fluid is delivered in one or more jets, and the thrombus within the blood vessel is broken down by hydrodynamic forces (eg, by concentrated fluid pressure, fluid velocity, and fluid flow rate). For example, the fluid impinges on the thrombus and through this binding mechanically macerates the thrombus. As will be discussed below, through the widened suction hole distal element 114, the suction lumen 110 absorbs the crushed thrombus and conveys it through the port 120 to a waste unit, such as a collection bag, vial, chute, etc. wait.
导管本体catheter body
在一个实施例中，导管本体120成型为远端部分108相对柔软，而近端部分104与其比较则相对坚硬。相对柔软的远端部分108使得导管本体120可以灵活地顺着血管行进并且可以灵活地穿行于血管以实现易于插入的目的。导管本体120更加坚硬的近端部分104考虑到了例如更加大的扭转能力以及能够沿引导线更加容易的前进。在一个例子中，与导管本体的其他部分相比，导管本体120的远端有近似6英寸的长度具有更加低的硬度。因为与6533PEBAX相比，7233PEBAX具有更加低的硬度值，所以在一种示例性的导管中，其远端部分108使用了6533PEBAX而近端部分104使用了7233PEBAX。In one embodiment, the catheter body 120 is shaped such that the distal portion 108 is relatively soft, while the proximal portion 104 is relatively rigid. The relatively flexible distal portion 108 allows the catheter body 120 to flexibly follow and pass through the blood vessel for ease of insertion. The stiffer proximal portion 104 of the catheter body 120 allows for greater torsion capability and easier advancement over a guidewire, for example. In one example, the distal end of catheter body 120 has a length of approximately 6 inches and is less rigid than the rest of the catheter body. Because 7233PEBAX has a lower durometer value than 6533PEBAX, in one exemplary catheter, 6533PEBAX is used for the distal portion 108 and 7233PEBAX is used for the proximal portion 104 .
在另一个实施例中，就导管本体的近端部分104、中间部分106和远端部分108而言，将其中的每一个都和其他部分单独比较后会发现，导管近端部分104具有高硬度值，导管中间部分106具有相对中等的硬度值，而导管远端部分108具有相对低的硬度值。和前面的例子一样，导管远端部分108和中间部分106较低的硬度值有助于导管在脉管系统内的输送和穿行。例如，导管本体102可穿过弯曲的脉管系统。导管近端部分相对高的硬度值(大于中间部分)协助提供对于导管本体102的推动能力以及扭转能力。In another embodiment, with respect to the proximal portion 104, intermediate portion 106 and distal portion 108 of the catheter body, each of which is individually compared to the other portions, the proximal portion 104 of the catheter has a high stiffness Values, the catheter middle portion 106 has a relatively medium hardness value, while the catheter distal portion 108 has a relatively low hardness value. As with the previous examples, the lower stiffness values of the catheter's distal portion 108 and intermediate portion 106 facilitate delivery and navigation of the catheter within the vasculature. For example, catheter body 102 may pass through tortuous vasculature. The relatively high stiffness value of the proximal portion of the catheter (greater than the mid portion) assists in providing push and twist capabilities for the catheter body 102 .
例如，若导管本体102如上文所描述的，包括了三个或者多个硬度值，可以由聚氨基甲酸酯或者PEBAX来形成该导管本体102，其导管近端部分104具有肖氏硬度A-A2的硬度DP，导管中间部分106具有B1-B2的硬度DI，而导管远端部分108具有C1-C2的硬度DD，其中DP>DI>DD。另一种方式表达，从导管近端部分104到导管远端部分108，导管本体102的硬度值(已经对应的刚度)逐渐减少。For example, if the catheter body 102, as described above, includes three or more durometer values, the catheter body 102 may be formed from polyurethane or PEBAX with the catheter proximal portion 104 having a Shore hardness of A- With a hardness DP of A2, the catheter middle portion 106 has a hardness DI of B1-B2, and the catheter distal portion 108 has a hardness DD of C1-C2, where DP>DI>DD. Expressed another way, from the catheter proximal portion 104 to the catheter distal portion 108, the stiffness value (already corresponding stiffness) of the catheter body 102 gradually decreases.
可选择地，具有多个硬度值结构的导管本体102可以通过共挤工艺成型。在一个例子中，使用了全间歇挤压(TIE)工艺。在TIE工艺中，从成直线的单独的模具中挤出两个或者两个以上不同硬度值的聚合树脂，较高硬度值的聚合物用作导管本体的近端(例如，导管近端部分104)，而较低硬度值的聚合物用作导管本体的远端(例如，导管远端部分108)，两者之间具有中间过渡区域，例如导管本体102的中间部分106。正如前面所讨论的，在一个例子中，6233PEBAX用作远端而7233PEBAX用作近端。在一个例子中，硬度值沿长度变化的挤出导管的剖面沿长度是均匀的。也就是说，导管材料根据所需要的硬度值以各种量逐渐混合，随后挤出。在另一个例子中，导管本体102硬度值的变化包括以首尾相连的方式先挤出近端部分104和远端部分108中的一个(例如，较高硬度值材料或者较低硬度值材料中的一种)，接着对于剩下的远端部分108或者近端部分104，将挤出树脂换成较低硬度值或者较高硬度值的材料。Optionally, the catheter body 102 with multiple durometer structures can be formed by a co-extrusion process. In one example, a total batch extrusion (TIE) process is used. In the TIE process, two or more polymeric resins of different durometer values are extruded from separate dies in line, with the higher durometer polymer being used as the proximal end of the catheter body (e.g., catheter proximal portion 104 ), while a lower durometer polymer is used for the distal end of the catheter body (eg, catheter distal portion 108 ), with an intermediate transition region in between, such as intermediate portion 106 of catheter body 102 . As previously discussed, in one example, a 6233PEBAX is used as the far end and a 7233PEBAX is used as the near end. In one example, the profile of the extruded conduit having a hardness value that varies along the length is uniform along the length. That is, the catheter material is gradually mixed in various amounts according to the desired hardness value, and then extruded. In another example, varying the durometer value of catheter body 102 includes extruding one of proximal portion 104 and distal portion 108 (e.g., a higher durometer material or a lower durometer material) in an end-to-end fashion. a), and then for the remaining distal portion 108 or proximal portion 104, the extruded resin is replaced with a material with a lower hardness value or a higher hardness value.
在其他的例子中，导管的剖面可以具有两层或者两层以上的材料。例如，在一个实施例中，远端和近端之间的过渡区域可以混合例如硬度值从6233PEBAX变化到7233PEBAX的材料。换种说法，多层不同硬度的材料可以共挤出，也可以对整个导管本体102，通过中止或者增加层来设置想要的硬度值。In other examples, the cross-section of the conduit may have two or more layers of material. For example, in one embodiment, the transition region between the distal and proximal ends may be admixed with materials ranging in durometer values from, for example, 6233PEBAX to 7233PEBAX. In other words, multiple layers of materials with different hardness can be co-extruded, and the desired hardness value can be set for the entire catheter body 102 by stopping or adding layers.
还是在其他的例子中，导管本体102可以使用所述记述领域其他已知的工艺来成型，包括但不限于，沿衬腔缩管，在接合处将不同直径的导管管材焊接在一起等等。In still other examples, catheter body 102 may be formed using other known processes in the described art, including, but not limited to, shrinking tubing along the liner lumen, welding catheter tubing of different diameters together at junctions, and the like.
图2示出了本公开一个实施例所描述的血栓切除术导管100的横剖视图。在这个例子中，灌注腔111相对于抽吸腔110位于偏离中心的位置，所述灌注腔111具有将其与抽吸腔110分开的隔壁202。导管本体102包括外导管面和内导管面，而抽吸腔110由内导管面限定。如图所示，外导管面无特征，而灌注腔111相对于外导管面凹入。在一个例子中，凹入的灌注腔111使得圆柱的剖面为等直径的，这有助于导管本体102的传输与穿行。进一步地，凹入的灌注腔111包括了由灌注腔侧壁所成型的位于抽吸腔110内的局部轮廓。灌注腔111位于抽吸腔110的边缘，确保可用于抽吸血栓物质穿过该抽吸腔而不受灌注腔干扰的整体轮廓为最大，例如灌注腔中心定位于抽吸腔或者沿着灌注腔壁贴着(正如灌注腔的侧壁与抽吸腔的侧壁分离)。FIG. 2 shows a cross-sectional view of a thrombectomy catheter 100 described in one embodiment of the present disclosure. In this example, the perfusion lumen 111 is located off-centre relative to the aspiration lumen 110 , the perfusion lumen 111 having a partition wall 202 separating it from the aspiration lumen 110 . Catheter body 102 includes an outer catheter face and an inner catheter face, and aspiration lumen 110 is defined by the inner catheter face. As shown, the outer catheter face is featureless and the perfusion lumen 111 is concave relative to the outer catheter face. In one example, the concave irrigation lumen 111 makes the cross-section of the cylinder uniform in diameter, which facilitates delivery and passage of the catheter body 102 . Further, the concave perfusion chamber 111 includes a partial contour within the suction chamber 110 formed by the sidewall of the perfusion chamber. The perfusion lumen 111 is located at the edge of the aspiration lumen 110, ensuring that the overall profile available for aspiration of thrombus material through the aspiration lumen without interference from the perfusion lumen is maximized, e.g. the perfusion lumen is centrally located on the aspiration lumen or along the perfusion lumen The wall is attached (just as the side wall of the irrigation chamber is separated from the side wall of the suction chamber).
在一个实施例中，导管本体102的直径为6French(Fr)并且使用0.014英寸的导丝进行插入。在另一个实施例中，导管本体102的直径为8French并且使用0.014英寸到0.035英寸的导丝进行插入。可选择地，导管本体102的直径可以包括其他尺寸，对应地要使用相应的输送导丝。In one embodiment, catheter body 102 has a diameter of 6 French (Fr) and is inserted using a 0.014 inch guide wire. In another embodiment, the catheter body 102 is 8 French in diameter and is inserted using a 0.014 inch to 0.035 inch guide wire. Alternatively, the diameter of catheter body 102 may comprise other dimensions, corresponding to which corresponding delivery guidewires are used.
在一个例子中，导管本体102具有均匀的横截面轮廓。换句话说，包括了灌注腔111和抽吸腔的导管本体102的横剖截面是一起成型的，相应地在灌注腔111的侧壁和抽吸腔110的侧壁之间不具有任何类型的接合线或者焊接线。这与两个腔分别成型然后再在随后的步骤中接合在一起的结构不同。导管本体102的均匀横剖面提供了更加坚固的结构，该结构可以防止一个腔相对于另一个腔的断裂或剥离，因为导管任何程度的弯曲或扭矩或者腔内的压力不会引起两腔之间接合线的断裂。另一种选择，抽吸腔110和灌注腔111可以分别成型，随后使用例如焊接、粘合、回流等方法连接在一起。In one example, catheter body 102 has a uniform cross-sectional profile. In other words, the cross-section of the catheter body 102 including the perfusion lumen 111 and the aspiration lumen is molded together, correspondingly without any type of gap between the side walls of the perfusion lumen 111 and the side walls of the aspiration lumen 110 bonding wire or soldering wire. This is different from a structure where two cavities are molded separately and then joined together in a subsequent step. The uniform cross-section of the catheter body 102 provides a more robust structure that prevents fracture or detachment of one lumen relative to the other because any degree of bending or torque of the catheter or pressure within the lumens will not cause contact between the two lumens. Breakage of the joint. Alternatively, the suction chamber 110 and the perfusion chamber 111 can be molded separately, and then connected together using methods such as welding, bonding, reflow, and the like.
图3示出了根据一个实施例所述的血栓切除术导管100远端108的立体图。图4示出了血栓切除术导管100远端108的侧视图。如这些例子中的每一个所示，远端部分包括了抽吸孔112和灌注孔304。如本文所描述的，在进行血栓切除术手术的过程中，抽吸孔112和灌注孔304相互配合来流体动力地从血管去除血栓，浸软血栓以及从血管抽离血栓。FIG. 3 shows a perspective view of the distal end 108 of the thrombectomy catheter 100 according to one embodiment. FIG. 4 shows a side view of the distal end 108 of the thrombectomy catheter 100 . As shown in each of these examples, the distal portion includes aspiration holes 112 and irrigation holes 304 . As described herein, the aspiration port 112 and the perfusion port 304 cooperate to hydrodynamically remove the thrombus from the blood vessel, macerate the thrombus, and withdraw the thrombus from the blood vessel during a thrombectomy procedure.
灌注系统Perfusion system
再参考图3和4，灌注腔111沿着导管本体102朝着远端部分108延伸，所述灌注腔111具有贯穿导管本体的灌注孔304(例如穿过导管本体紧邻灌注腔111的侧壁)，所述灌注孔304引导从导管本体102射出的流体射流。正如本文所描述的，灌注腔111与配置用来提供加压流体的流体源流体连接，所述加压流体可以是在例如大约1500psi或者小于1500psi压力下的盐水。传输加压流体穿过灌注孔304，并且由灌注孔304调节流量以形成血栓切除术手术用流体射流。Referring again to FIGS. 3 and 4 , a perfusion lumen 111 extends along the catheter body 102 toward the distal portion 108, the perfusion lumen 111 having a perfusion hole 304 extending through the catheter body (e.g., through the sidewall of the catheter body immediately adjacent the perfusion lumen 111) , the irrigation hole 304 directs the fluid jet emitted from the catheter body 102 . As described herein, perfusion lumen 111 is in fluid communication with a fluid source configured to provide a pressurized fluid, which may be saline at, for example, a pressure of about 1500 psi or less. The pressurized fluid is delivered through the perfusion hole 304 and the flow is regulated by the perfusion hole 304 to form a thrombectomy fluid jet.
在本公开的一个实施例中，将单个灌注孔304设置成可以引导流体射流从导管本体102的纵轴径向射出的构造。例如，单个灌注孔304指向远离导管本体102的方向以确保在灌注孔生成的流体射流朝着导管本体102周围的血管内的血栓冲击。通过旋转导管本体102(例如近端部分104具有更高硬度值的导管本体)，灌注孔304和相应的流体射流经过了血管的整个尺度，因此能够去除导管远端部分108周围的全部血栓。在一个例子中，灌注孔304的直径大约为0.009英寸。在另一个例子中，灌注孔304的直径大约为0.012英寸。可选择地，可以根据加压流体源(例如，与导管本体102连接的泵系统的压力和流速)，配置灌注孔304的直径以产生具有需要速度和流体流速的流体射流。换句话说，配置灌注孔304的形状和尺寸来与流体源配合以设置流体射流具有需要的速度值和流速值。In one embodiment of the present disclosure, a single irrigation hole 304 is configured to direct a jet of fluid radially from the longitudinal axis of the catheter body 102 . For example, a single perfusion hole 304 is directed away from the catheter body 102 to ensure that the fluid jet generated at the perfusion hole impinges on the thrombus within the blood vessel surrounding the catheter body 102 . By rotating the catheter body 102 (eg, a catheter body with a higher stiffness value at the proximal portion 104 ), the perfusion holes 304 and corresponding fluid jets traverse the full extent of the vessel, thereby enabling removal of all thrombus around the catheter distal portion 108 . In one example, the irrigation hole 304 is approximately 0.009 inches in diameter. In another example, the irrigation hole 304 has a diameter of approximately 0.012 inches. Alternatively, the diameter of irrigation hole 304 may be configured to generate a fluid jet having a desired velocity and fluid flow rate based on a source of pressurized fluid (eg, the pressure and flow rate of a pump system coupled to catheter body 102 ). In other words, the shape and size of the irrigation hole 304 is configured to cooperate with the fluid source to set the fluid jet to have a desired velocity value and flow rate value.
在上文所描述的例子中，设置了单个灌注孔304。在其他的例子中，在导管本体102的一个或者多个位置上设置了多个灌注孔304(例如，径向环绕导管远端部分104、纵向等等)。如图4所示，单个灌注孔304集中了灌注流体的流体动力能以更好地击碎血栓形成。也就是说，通过使用单个灌注孔304，即使使用低压流体源(例如，具有1到3cc低流速的1500psi或者少于1500psi)也可以在孔304产生具有足够流体动力能量的流体射流来实施血栓切除手术，而在通常情况下，为所述流体射流准备的是提供高压流体的流体源(例如，10,000psi或者10,000psi以上)。灌注孔304处的集中射流接着可以在人体血管周围穿行，提供与使用多个导管进行高压血栓切除术治疗相似的功效，上述使用的多个导管具有多个射流孔且具有足以传输高压流体的坚固的结构。In the example described above, a single perfusion hole 304 was provided. In other examples, multiple perfusion holes 304 are provided at one or more locations on the catheter body 102 (eg, radially around the catheter distal portion 104, longitudinally, etc.). As shown in Figure 4, a single perfusion hole 304 concentrates the hydrodynamic energy of the perfusion fluid to better disrupt thrombus formation. That is, by using a single perfusion port 304, a fluid jet with sufficient hydrodynamic energy can be generated at the port 304 to perform thrombectomy even with a low pressure fluid source (e.g., 1500 psi or less with a low flow rate of 1 to 3 cc). surgery, and typically, a fluid source providing high pressure fluid (eg, 10,000 psi or more) is provided for the fluid jet. The focused jet at the perfusion hole 304 can then travel around the body's blood vessels, providing efficacy similar to high pressure thrombectomy therapy using multiple catheters with multiple jet holes and strong enough to deliver high pressure fluid. Structure.
血栓切除术导管100不同的实施例使用不同的灌注流体流速。一个例子中的导管使用大约1.5cc/sec的流速在灌注孔304提供流体射流，所述流体射流被设定用来去除和浸软血栓。另一个例子中使用的是2cc/sec。还是在另一个例子中使用的是大约3cc/sec。正如上文所描述的，灌注流体离开灌注孔304时的速度和流速取决于流体源的流速和压力以及灌注孔304的尺寸和形状。正如本文下面所要描述的，例如药物喷注器或者造影喷注器的低压流体源可以用作血栓切除术导管100的流体源。本文所描述的具有灌注孔304和灌注腔111的血栓切除术导管100因此提供了一种血栓切除术系统，该系统在使用低压和低流速(例如，药物和造影)喷注器时也可以设定用来有效去处和浸软血栓，而未必需要其他血栓切除术手术中所使用的高压流体源。Different embodiments of the thrombectomy catheter 100 use different perfusion fluid flow rates. One example catheter provides a fluid jet at the perfusion port 304 using a flow rate of about 1.5 cc/sec, which is set to dislodge and macerate the thrombus. Another example uses 2cc/sec. Still in another example about 3cc/sec was used. As described above, the velocity and flow rate of the perfusion fluid as it exits the perfusion hole 304 depends on the flow rate and pressure of the fluid source and the size and shape of the perfusion hole 304 . As will be described herein below, a low pressure fluid source such as a drug injector or a contrast injector may be used as the fluid source for the thrombectomy catheter 100 . The thrombectomy catheter 100 described herein having the perfusion port 304 and the perfusion lumen 111 thus provides a thrombectomy system that can also be configured when using low pressure and low flow rate (e.g., drug and contrast) injectors. It is designed to effectively dislodge and macerate thrombi without necessarily requiring the high-pressure fluid sources used in other thrombectomy procedures.
在一个例子中，灌注腔111和灌注孔304被配置成，缓和溶血和流体动力能量对血细胞的破坏。对于缓和溶血，本系统将灌注速度限制在大约20m/sec到大约30m/sec的范围内。在一个例子中，设定灌注孔304的尺寸和形状来与穿过导管的流速配合(相应地与加压流体源配合)，以确保孔304处的灌注速度在大约20m/sec到大约30m/sec之间。通过集中穿过灌注孔304的灌注流，所述灌注孔304具有规定的直径和形状且在导管本体102上具有单个位置，在提供用于血栓浸软的局部化灌注流体的射流的同时，灌注速度是容易控制的。In one example, perfusion lumen 111 and perfusion holes 304 are configured to moderate hemolysis and damage to blood cells by hydrodynamic energy. For moderate hemolysis, the present system limits perfusion velocity to a range of about 20 m/sec to about 30 m/sec. In one example, the perfusion hole 304 is sized and shaped to match the flow rate through the catheter (and accordingly the source of pressurized fluid) to ensure that the perfusion velocity at the hole 304 is between about 20 m/sec to about 30 m/sec. between sec. By focusing the perfusion flow through the perfusion hole 304, which has a defined diameter and shape and has a single location on the catheter body 102, while providing a localized jet of perfusion fluid for thrombus maceration, the perfusion Speed is easy to control.
抽吸系统suction system
在这个例子中，抽吸腔110包括在导管本体102远端113开口的抽吸孔112。在一个例子中，射线不能穿过的套环位于远端部分108。在荧光透视下，在穿插血管的过程中，射线不能穿过的套环协助导管远端部分108成像。In this example, the suction lumen 110 includes a suction hole 112 opening at a distal end 113 of the catheter body 102 . In one example, a radiopaque collar is located at the distal portion 108 . Under fluoroscopy, the radiopaque collar assists in imaging the catheter distal portion 108 during insertion through the blood vessel.
在一个例子中，远端113包括加宽的抽吸孔远端元件114(例如，与邻近的导管本体102的部分相比，具有轮廓更加大的广口部分)。如图3所示，加宽的抽吸孔远端元件114包括连接到导管本体112端117的近端部分116。加宽的抽吸孔远端元件114在近端部分116包括与抽吸腔110尺寸相似的开口。加宽的抽吸孔远端元件114的远端118包括比抽吸腔110更加宽的开口。通过热合、焊接、粘合、回流等工艺中的一种或多种，加宽的抽吸孔远端元件114连接到导管本体102的端部。正如下文将要进一步讨论的，这种加宽的、漏斗形的远端元件114(例如，广口特征)改进了抽吸。In one example, the distal end 113 includes a widened suction aperture distal element 114 (eg, having a wider mouth portion with a wider profile than adjacent portions of the catheter body 102 ). As shown in FIG. 3 , the widened suction bore distal element 114 includes a proximal portion 116 connected to an end 117 of the catheter body 112 . The widened suction aperture distal element 114 includes an opening at a proximal portion 116 that is similar in size to the suction lumen 110 . The distal end 118 of the widened suction aperture distal element 114 includes a wider opening than the suction lumen 110 . The widened suction hole distal element 114 is attached to the end of the catheter body 102 by one or more of heat sealing, welding, gluing, reflow, and the like. As will be discussed further below, this widened, funnel-shaped distal element 114 (eg, wide mouth feature) improves suction.
图5示出了未与导管本体102连接状态下的，加宽的抽吸孔远端元件114的端部视图。图6A示出了位于血管604内的血栓切除术导管100的侧视图，该血栓切除术导管100具有与其连接且与血栓602结合的加宽抽吸孔远端元件114。FIG. 5 shows an end view of the widened suction hole distal element 114 in a state unattached to the catheter body 102 . FIG. 6A shows a side view of a thrombectomy catheter 100 within a blood vessel 604 with a widened suction bore distal element 114 coupled thereto and engaging a thrombus 602 .
再参考图5，加宽抽吸孔远端元件114的广口界定了内倾斜面502，所述内倾斜面502从远端118向内延伸到加宽抽吸孔远端元件114的近端，所述近端连接到导管本体104并且与抽吸腔110连通。在一个例子中，加宽的抽吸孔远端元件114和抽吸腔110之间的接口相对光滑或齐平，这有助于血栓从加宽的抽吸孔远端元件114到抽吸腔110的过渡。Referring again to FIG. 5 , the wide mouth of the widened suction hole distal element 114 defines an inner sloped surface 502 that extends inwardly from the distal end 118 to the proximal end of the widened suction hole distal element 114. , the proximal end is connected to the catheter body 104 and communicates with the suction lumen 110 . In one example, the interface between the widened suction hole distal element 114 and the suction lumen 110 is relatively smooth or flush, which facilitates passage of thrombus from the widened suction hole distal element 114 to the suction lumen 110 transition.
如图5和6A所示，加宽抽吸孔远端元件114从其顶端到其与导管本体102连接处之间的内容积没有结构上的障碍物。换句话说，内倾斜面502基本上是连续的，因此没有任何阻碍(例如，隆起、凸起等等)。也就是说，远端元件114的远端118在该远端以及近该远端处基本上是连续的(例如，没有障碍物)。因此，当血栓602被抽吸进入到导管，血栓在远端元件114的远端或者在远端元件114内变成楔形。接着远端元件114的漏斗形贴住血栓进行密封，而抽吸腔110的抽吸压力继续真空处理，并且使血栓602陷缩进入到逐渐狭窄的加宽抽吸孔远端元件114以使血栓碎成大小适于抽吸腔110且能沿抽吸腔110传输的更小的块。As shown in FIGS. 5 and 6A , the inner volume of the widened suction hole distal element 114 from its tip to its junction with the catheter body 102 is free of structural obstructions. In other words, the inner sloped surface 502 is substantially continuous and thus free of any obstructions (eg, bumps, bumps, etc.). That is, the distal end 118 of the distal element 114 is substantially continuous (eg, free of obstructions) at and near the distal end. Thus, when the thrombus 602 is aspirated into the catheter, the thrombus becomes wedge-shaped at the distal end of the distal element 114 or within the distal element 114 . The funnel shape of the distal element 114 then seals against the thrombus while the suction pressure of the suction lumen 110 continues to vacuum and collapse the thrombus 602 into the progressively narrowing widened suction hole of the distal element 114 to free the thrombus. Break into smaller pieces that are sized for the suction lumen 110 and can be transported along the suction lumen 110 .
图6B和6C示出了正在被抽吸的血栓的进一步的细节。图6B为血栓切除术导管110的侧视图，其中血栓602在广口远端元件114内坍缩且朝着近导管端转移。图6C示出了血栓切除术导管110的侧视图，其中血栓602被坍缩(或者压碎)到血栓切除术导管110更小直径部分内且朝着导管近端转移用以排出。Figures 6B and 6C show further details of a thrombus being aspirated. 6B is a side view of the thrombectomy catheter 110 with the thrombus 602 collapsing within the wide-bore distal element 114 and migrating toward the proximal catheter end. 6C shows a side view of the thrombectomy catheter 110 with a thrombus 602 collapsed (or crushed) into the smaller diameter portion of the thrombectomy catheter 110 and diverted toward the proximal end of the catheter for drainage.
所述的广口形状减少了血栓与抽吸腔之间的间隙周围的任何流体分流的发生，该流体分流(例如，泄漏)减少了作用在加宽抽吸孔远端元件114内血栓的抽吸压力(例如，真空)。也就是说，无障碍环形的加宽抽吸孔远端元件114使得血栓能够沿元件就位，并且基本上防止在血栓与远端元件114内突起物之间形成间隙。血栓周围的流体泄漏因此基本上最小化，而且全真空的抽吸腔110施加到血栓上。The described wide-mouth shape reduces the occurrence of any fluid shunting around the gap between the thrombus and the suction lumen, which fluid shunting (e.g., leakage) reduces the suction of the thrombus acting on the widened suction hole distal element 114. Suction pressure (eg, vacuum). That is, the unobstructed annular widening of the suction hole distal element 114 enables the thrombus to be seated along the element and substantially prevents the formation of a gap between the thrombus and protrusions within the distal element 114 . Fluid leakage around the thrombus is thus substantially minimized, and a full vacuum of suction lumen 110 is applied to the thrombus.
图7示出了血栓切除术导管702的横剖视图，其中灌注腔711完全定位于导管的侧壁。灌注腔的这种配备确保了抽吸腔710的剖面基本上是等直径的。在一些例子中，等直径的抽吸腔710(没有障碍物)有助于吸收以及血栓穿过内腔的运输。另一种选择，导管702在一部分导管中，例如远端108或者近端104的导管中，灌注腔711在导管的侧壁内，而在另一部分导管部分中，例如近端104或者远端108的导管中，另一部分的灌注腔711部分出现在抽吸腔内(如图2所示)。因此在需要高效输送血栓朝近侧穿过抽吸腔的地方，导管702包括了等直径的抽吸腔710。Figure 7 shows a cross-sectional view of a thrombectomy catheter 702 with the perfusion lumen 711 positioned entirely on the side wall of the catheter. This configuration of the perfusion lumen ensures that the cross-section of the aspiration lumen 710 is substantially equal in diameter. In some instances, a suction lumen 710 of equal diameter (without obstructions) facilitates absorption and transport of thrombus through the lumen. Alternatively, the catheter 702 is in a part of the catheter, such as the catheter at the distal end 108 or the proximal end 104, and the perfusion lumen 711 is in the side wall of the catheter, and in another part of the catheter, such as the proximal end 104 or the distal end 108. In the catheter, another part of the perfusion lumen 711 appears in the suction lumen (as shown in FIG. 2 ). Catheter 702 thus includes a suction lumen 710 of equal diameter where efficient delivery of thrombus proximally through the suction lumen is desired.
图8示出了根据另一实施例所述的血栓切除术导管802的远端。在这个例子中，广口远端元件814的端部具有带斜面的形状815。加宽抽吸孔远端元件814带斜面的形状协助装置插入到血管并且协助装置在血管内穿行。斜面形状815是从一远端的顶端朝着近端部分824向上倾斜渐缩而来。加宽抽吸孔远端元件814的抽吸孔820吸收血栓。斜面形状的作用与上文所描述的广口远端元件114类似。因此，加宽抽吸孔远端元件814没有任何结构上的障碍物，环形地贴住远端元件814内的血栓，并且贴住所有的血栓形成密封以防止血栓与抽吸腔之间的间隙周围发生流体泄漏。Figure 8 shows the distal end of a thrombectomy catheter 802 according to another embodiment. In this example, the end of the wide-mouth distal element 814 has a beveled shape 815 . The beveled shape of the widened suction aperture distal element 814 assists in insertion of the device into a blood vessel and in navigation of the device within the blood vessel. The ramp shape 815 tapers obliquely upwardly from a distal tip towards a proximal portion 824 . The suction hole 820 of the widened suction hole distal element 814 absorbs thrombus. The bevel shape functions similarly to the wide-mouth distal element 114 described above. Thus, the widened suction hole distal element 814 is free of any structural obstructions, annularly fits against the thrombus in the distal element 814, and forms a seal against all thrombus to prevent a gap between the thrombus and the suction lumen. Fluid leaks around.
加压流体传输系统pressurized fluid transfer system
图9A示出了根据一个实施例的血栓切除术系统900的一部分。该血栓切除术系统900包括如图1所示的血栓切除术导管100，该血栓切除术导管100具有侧端口122和中心端口，所述侧端口122连接到例如喷注器902的流体传输装置，所述中心端口连接到例如真空源的抽吸器904。FIG. 9A shows a portion of a thrombectomy system 900 according to one embodiment. The thrombectomy system 900 includes a thrombectomy catheter 100 as shown in FIG. 1 having a side port 122 connected to a fluid transfer device such as an injector 902 and a center port, The central port is connected to an aspirator 904 such as a vacuum source.
举例来说，在使用中，血栓切除术导管100使用导丝插入到血管。引导血栓切除术导管100的远端部分108穿过脉管系统并将其放置在紧邻血栓的位置。举例来说，喷注器902设置为以大约1cc/s，1.5cc/s，2cc/s或者3cc/s等来输送灌注流体。喷注器902包括但不限于，配置用于造影传输或者药物传输中的一种或者多种的低压喷注器。在大约300psi到大约2000psi之间的范围内配置低压流体源向血栓切除术导管100(802)提供灌注流体。正如上文所讨论的，根据由喷注器902所提供的这些较低的流体压力(以及与其他血栓切除术手术中所使用的高压和高流动流体源相比的较低流速)，可以通过对灌注腔111和灌注孔304的形状和直径进行配置来提供具有需要流动特性(例如，速度和流速)的流体射流，所述流体射流配置用来去除和浸软血栓。正如本文所讨论的，提供单个灌注孔304可以将流体射流局限到单个位置，并且考虑到使用较抵压力的流体仍然可以去除血栓。换种说法，单个灌注孔304可以避免多个压力孔压力下降时的后果，取而代之的是单个灌注孔304可以在单个位置集中由低压喷注器902所提供的流体动力能。在其他的例子中可以使用其他的流体传输装置，例如手持喷注器，高压喷注器(例如，10,000psi)等。本文所描述的具有灌注孔304和灌注腔111的血栓切除术导管100提供了一种，在使用包含了连续传输泵的低压以及低流速(例如药物和造影)喷注器时，仍能进行有效配置以去除和浸软血栓的血栓切除术系统，而不需要昂贵的以及专门的高压流体源(例如，泵、喷注器等)。For example, in use, the thrombectomy catheter 100 is inserted into a blood vessel using a guide wire. The distal portion 108 of the thrombectomy catheter 100 is guided through the vasculature and placed in close proximity to the thrombus. For example, injector 902 is configured to deliver perfusion fluid at about 1 cc/s, 1.5 cc/s, 2 cc/s, or 3 cc/s, etc. Injector 902 includes, but is not limited to, a low pressure injector configured for one or more of contrast delivery or drug delivery. A low pressure fluid source is configured to provide perfusion fluid to thrombectomy catheter 100 (802) in a range between about 300 psi and about 2000 psi. As discussed above, with these lower fluid pressures provided by injector 902 (and lower flow rates compared to high pressure and high flow fluid sources used in other thrombectomy procedures), it is possible to The shape and diameter of the perfusion lumen 111 and perfusion holes 304 are configured to provide a fluid jet with desired flow characteristics (eg, velocity and flow rate) configured to remove and macerate the thrombus. As discussed herein, providing a single irrigation hole 304 can confine the fluid jet to a single location and allow for the use of relatively high pressure fluids that can still remove the thrombus. Stated another way, a single irrigation hole 304 can avoid the consequences of multiple pressure port pressure drops, and instead a single irrigation hole 304 can concentrate the hydrodynamic energy provided by the low pressure injector 902 at a single location. In other instances other fluid transfer devices may be used, such as hand-held injectors, high-pressure injectors (eg, 10,000 psi), etc. The thrombectomy catheter 100 described herein having the perfusion port 304 and perfusion lumen 111 provides a method for effectively performing the procedure while using low pressure and low flow (eg, drug and contrast) injectors including continuous delivery pumps. A thrombectomy system configured to remove and macerate a thrombus without requiring expensive and specialized high pressure fluid sources (eg, pumps, injectors, etc.).
当灌注流体去除和击碎血栓时，启动与抽吸腔110连接的抽吸器904来抽吸物质。抽吸器904包括例如真空注射器、真空泵等的真空源。While the perfusion fluid dislodges and breaks up the thrombus, the aspirator 904 connected to the aspiration lumen 110 is activated to aspirate the material. Aspirator 904 includes a vacuum source such as a vacuum syringe, vacuum pump, or the like.
图9B中示出的另一个实施例为可与本系统合用的喷注器系统1200，例如Medrad喷注器系统。这个例子使用了控制模块1400以及动力喷注器1300，将注射器连接到所述动力喷注器1300。流体控制模块1400联合喷注器1300一起用来控制由喷注器1300传输的流体流动。流体控制模块1400通常适合对流体路径装置组进行支持和控制，所述流体路径装置组用来将与喷注器1300相联系的注射器连接到要与病人相联系的导管(未示出)。盐水源1706与蠕动泵1408流体连接。Another embodiment shown in Figure 9B is an injector system 1200 that may be used with the present system, such as a Medrad Injector system. This example uses a control module 1400 and a power injector 1300 to which the injector is connected. Fluid control module 1400 is used in conjunction with injector 1300 to control the flow of fluid delivered by injector 1300 . Fluid control module 1400 is generally adapted to support and control the fluid path set used to connect a syringe associated with injector 1300 to a catheter (not shown) to be associated with a patient. Saline source 1706 is fluidly connected to peristaltic pump 1408 .
正如本文所进一步讨论的，流体输送系统1200进一步包括适合用来对喷注器1300和流体控制模块1400进行支撑的支撑组件1600。可以将支撑组件1600构造成可移动的平台或者底座，使得流体输送系统1200通常是可运输的，或者就将其连接到注射操作过程中病人所在的标准医院病床或者检查台。另外，流体输送系统1200最好进一步包括用户输入控制部分或装置1800，所述用户输入控制部分或装置1800与流体控制模块1400和/或喷注器1300的计算机硬件/软件(例如，电子存储器)交互。流体控制模块1400通常包括外壳1402、控制流体控制阀的阀致动器1404、液位检测机构1406、蠕动泵1408、自动截流阀或者自动夹管阀，以及空气探测组件。As discussed further herein, fluid delivery system 1200 further includes a support assembly 1600 adapted to support injector 1300 and fluid control module 1400 . The support assembly 1600 can be configured as a movable platform or base so that the fluid delivery system 1200 is generally transportable, or it can just be attached to a standard hospital bed or examination table where the patient is placed during an injection procedure. In addition, the fluid delivery system 1200 preferably further includes a user input control portion or device 1800 that interacts with the fluid control module 1400 and/or the computer hardware/software (e.g., electronic memory) of the injector 1300 interact. The fluid control module 1400 generally includes a housing 1402, a valve actuator 1404 to control the fluid control valve, a liquid level detection mechanism 1406, a peristaltic pump 1408, an automatic shutoff valve or automatic pinch valve, and an air detection assembly.
正如所指出的，流体控制模块1400通常适合对流体路径套件1700进行支持和控制，所述流体路径套件1700用来将与喷注器1300相联系的注射器连接到导管(未示出)。在通常的涉及流体输送系统1200的注射操作中，喷注器1300充有来自第一流体容器1704的流体，并且通过流体路径套件1700将该流体输送到导管，并且最终输送到病人。流体控制模块1400一般通过与流体路径套件1700有联系的阀来控制或者管理注射剂的输送，所述阀由控制模块1400上的阀致动器1404来控制或者致动。As noted, fluid control module 1400 is generally adapted to support and control fluid path kit 1700 used to connect syringes associated with injector 1300 to catheters (not shown). In a typical injection operation involving fluid delivery system 1200, injector 1300 is filled with fluid from first fluid container 1704, and the fluid is delivered through fluid path set 1700 to the catheter and ultimately to the patient. Fluid control module 1400 typically controls or manages the delivery of injectables through valves associated with fluid path kit 1700 that are controlled or actuated by valve actuator 1404 on control module 1400 .
流体控制模块1400进一步适合通过流体控制模块1400上的蠕动泵1408在压力下对来自第二流体容器1706的流体进行传输。在一个实施例中，手持控制器1000包含了柱塞控制或者杆控制1010，当在第一压力/低压力模式下时，操作者按下所述柱塞或杆来控制来自注射器1300的流体的流动。将柱塞1010按地越远，流速越大(例如，借助位于控制器1000外壳内的例如线性电位计之类的电位计)。在一个实施例中，操作者可以使用图形用户界面显示器来将柱塞1010的模式改变到第二模式，在第二模式中，就像操作者预先编程的一样，喷注器1300引起高压注射。The fluid control module 1400 is further adapted to deliver fluid under pressure from the second fluid container 1706 via a peristaltic pump 1408 on the fluid control module 1400 . In one embodiment, the handheld controller 1000 includes a plunger control or lever control 1010 that the operator depresses to control the flow of fluid from the syringe 1300 when in the first pressure/low pressure mode. flow. The farther the plunger 1010 is pushed, the greater the flow rate (eg, via a potentiometer such as a linear potentiometer located within the controller 1000 housing). In one embodiment, the operator may use the graphical user interface display to change the mode of the plunger 1010 to a second mode in which the injector 1300 causes a high pressure injection as pre-programmed by the operator.
图10示出了根据一个实施例所示的真空源950的立体图。图11示出了真空源950的主视图。Figure 10 shows a perspective view of a vacuum source 950, according to one embodiment. FIG. 11 shows a front view of vacuum source 950 .
在这个例子中，真空源950是可重装的真空源。在一个例子中，上文所描述的本系统使用150cc容量的注射器通过盐水灌注自动造影喷注器。在这个例子中，抽吸式装置(例如，真空源950)的抽吸容量使用类似的尺寸。例如，如果与喷注器902一起使用的是标准的30cc注射器，那么当相应的真空源950的30cc注射器充满时，为了避免解剖学上的流体净减少或者净增加，操作要停止。In this example, vacuum source 950 is a refillable vacuum source. In one example, the system described above uses a 150 cc capacity syringe to prime the autocontrast injector with saline. In this example, similar dimensions are used for the suction capacity of the suction device (eg, vacuum source 950). For example, if a standard 30cc syringe is used with injector 902, then when the corresponding 30cc syringe of vacuum source 950 is filled, operation is stopped in order to avoid a net decrease or gain in anatomical fluid.
在图10和11所示的例子中，真空源950包括一系列的60cc注射器952，所述注射器通过旋塞阀式歧管954组成一套。所属领域的人员可以理解注射器所使用的数量和尺寸可以变化。可选择地，与灌注源(例如，喷注器902)相比，多个注射器952可以具有更加大的容量，而且在所有操作之前，多个注射器952可以全部重设。在一个例子中，将框形保持架956连接到真空源组件950，以使得注射器952直立且可视(相应地解放双手)。可以根据歧管954的尺寸和所需的抽吸强度(以及喷注器的容量)使用任何数量的注射器952。In the example shown in FIGS. 10 and 11 , the vacuum source 950 includes a series of 60 cc syringes 952 grouped together by a stopcock manifold 954 . Those skilled in the art will appreciate that the number and size of syringes used may vary. Alternatively, the plurality of syringes 952 can have a larger capacity than the perfusion source (eg, injector 902 ), and the plurality of syringes 952 can all be reset before all operations. In one example, frame-shaped holder 956 is attached to vacuum source assembly 950 such that syringe 952 is upright and visible (resulting in hands free). Any number of injectors 952 may be used depending on the size of the manifold 954 and the desired aspiration strength (and injector capacity).
在使用中，真空源950(例如，抽吸器904)通过鲁尔连接器连接到血栓切除术导管100，并且打开一个或多个旋塞阀。在抽吸器904打开以后，被抽吸物质，例如穿过加宽的抽吸孔远端元件114涌进导管100，随后沿抽吸腔110被输送，进入到了一个或者多个已经打开的注射器952。在一个或者多个注射器充满以后，如果需要另外的注射器，则打开另外的注射器。如果操作完成，封闭注射器952，比方说使用旋塞阀式歧管954，并且更换或者清洁注射器952，为下次操作做准备。In use, a vacuum source 950 (eg, aspirator 904 ) is connected to thrombectomy catheter 100 via a luer connector, and one or more stopcocks are opened. After the aspirator 904 is opened, the aspirated substance, for example, rushes into the catheter 100 through the widened suction hole distal element 114, and is then transported along the suction lumen 110 into one or more opened syringes. 952. After one or more syringes are filled, additional syringes are opened if required. If the operation is complete, the syringe 952 is closed, say using a stopcock manifold 954, and the syringe 952 is replaced or cleaned in preparation for the next operation.
喷注系统injection system
图12A示出了根据本公开一个实施例的喷注器系统一个例子1800的示意图。图12B示出了根据本公开一个实施例的喷注器系统另一个例子1900的示意图。Figure 12A shows a schematic diagram of an example 1800 of an injector system according to one embodiment of the present disclosure. Figure 12B shows a schematic diagram of another example 1900 of an injector system according to one embodiment of the present disclosure.
所述喷注器系统1800、1900为能够与各种诊断导管和介入导管一起使用的流体管理机构。该系统结合了各种流体传输和管理能力。The injector system 1800, 1900 is a fluid management mechanism that can be used with various diagnostic and interventional catheters. The system combines various fluid transfer and management capabilities.
参考图12A，喷注器系统1800包括高压单个活塞泵1802。例如，配置该泵来为标准血栓切除术导管提供高压流体传输。在一些例子中提供大约5,000psi到大约10,000psi的压力。Referring to FIG. 12A , injector system 1800 includes a high pressure single piston pump 1802 . For example, the pump is configured to provide high pressure fluid delivery for standard thrombectomy catheters. In some examples a pressure of about 5,000 psi to about 10,000 psi is provided.
系统1800进一步包括多活塞泵1804。配置多活塞泵1804来为成像造影传输、冲洗剂以及要使用上述的血栓切除术导管100来进行应用的流体提供中压/低压流动。配置多活塞泵1804以大约1500psi以及大到50ml/sec的流速来泵注造影剂或盐水。某些选项具有大约1000psi的传输压力。某些的范围可以从500psi到2500psi。泵1804是连续流泵(例如，它不必像注射泵那样进行再灌注)。System 1800 further includes multi-piston pump 1804 . The multi-piston pump 1804 is configured to provide medium/low pressure flow for imaging contrast delivery, irrigants, and fluids to be applied using the thrombectomy catheter 100 described above. The multi-piston pump 1804 is configured to pump contrast media or saline at approximately 1500 psi and flow rates as high as 50 ml/sec. Some options have delivery pressures of approximately 1000psi. Some can range from 500psi to 2500psi. Pump 1804 is a continuous flow pump (eg, it does not have to be refilled like a syringe pump).
一种选择是进一步包括单活塞泵1806。配置泵1806以1500psi以及大到50ml/sec的流速来泵注造影剂或盐水，但是该泵必须再灌注。在系统1800的一些实施例中，泵1806或者泵1804被省略。One option is to further include a single piston pump 1806. The pump 1806 is configured to pump contrast or saline at 1500 psi and flow rates as high as 50 ml/sec, but the pump must be reprimed. In some embodiments of system 1800, either pump 1806 or pump 1804 is omitted.
为了将流体输送到导管或者其他工具，泵1802、1804和1806中的每一个都可操作地连接到出口的流体线1810。将泵1802、1804和1806设计成可独立操作，其中一次仅一个泵会输送流体。Each of the pumps 1802, 1804, and 1806 is operatively connected to an outlet fluid line 1810 for delivering fluid to a catheter or other implement. Pumps 1802, 1804, and 1806 are designed to operate independently, with only one pump delivering fluid at a time.
系统1800进一步包括抽吸模块1812。抽吸模块1812配置成通过或者输送导管或者单独的导管来抽回流体。System 1800 further includes a suction module 1812 . The suction module 1812 is configured to withdraw fluid through either the delivery conduit or a separate conduit.
将泵1802、1804和1806中的每一个配置成共用一个共同的结构。例如，系统1800可以任选地包括操作电源系统1820、图形用户界面(GUI)1822、流体保证/空气探测模块1824，以及一个或多个容积流体源1826、1828。在一个选择中包括了配置用来提供流体动态混合以及监视流体1826、1828剩余容量的模块1832。在一些选择中，进一步准备了多用途一次性、交互和信息连通性、以及导管/一次性识别。Each of the pumps 1802, 1804, and 1806 are configured to share a common structure. For example, system 1800 may optionally include an operating power system 1820 , a graphical user interface (GUI) 1822 , a fluid assurance/air detection module 1824 , and one or more volumetric fluid sources 1826 , 1828 . In one option includes a module 1832 configured to provide dynamic mixing of fluids and monitor remaining volumes of fluids 1826,1828. In some options, multipurpose disposables, interactive and information connectivity, and catheter/disposable identification are further prepared.
在不同的实施例中，上文所讨论的某些特征以不同的方式进行组合。在一个例子的配置中，将泵1802和1804与抽吸模块1812，以及标准血栓切除术导管、血栓切除术导管100或者诊断导管中的至少一个或者多个进行组合。在另一个例子的配置中，将泵1802和1806与抽吸模块1812，以及标准血栓切除术导管、血栓切除术导管100或者诊断导管中的至少一个或者多个进行组合。仍然在另一个例子的配置中，将泵1804与抽吸模块1812，以及血栓切除术导管100或者诊断导管中的一个或者多个进行组合。在另外的配置中，将泵1806与抽吸模块1812，以及血栓切除术导管100或者诊断导管中的一个或者多个进行组合。然而在另外一个例子的配置中，将泵1806与抽吸模块1812、血栓切除术导管100或者诊断导管中的一个或者多个进行组合。另一个配置组合了泵1806与导管100或诊断导管中的一个或多个。另一个配置包括了单个泵活塞1806，且能够与上文所讨论的造影喷注器或者血栓切除术导管100一起工作。反过来说，第一个描述配置更加复杂，因为其兼容所有的导管且全能。Some of the features discussed above are combined in different ways in different embodiments. In one example configuration, pumps 1802 and 1804 are combined with suction module 1812, and at least one or more of a standard thrombectomy catheter, thrombectomy catheter 100, or a diagnostic catheter. In another example configuration, pumps 1802 and 1806 are combined with suction module 1812, and at least one or more of a standard thrombectomy catheter, thrombectomy catheter 100, or a diagnostic catheter. In still another example configuration, the pump 1804 is combined with the suction module 1812, and one or more of the thrombectomy catheter 100 or the diagnostic catheter. In additional configurations, the pump 1806 is combined with the suction module 1812, and one or more of the thrombectomy catheter 100 or diagnostic catheter. In yet another example configuration, the pump 1806 is combined with one or more of the suction module 1812, the thrombectomy catheter 100, or the diagnostic catheter. Another configuration combines pump 1806 with one or more of catheter 100 or a diagnostic catheter. Another configuration includes a single pump piston 1806 and is capable of working with the contrast injector or thrombectomy catheter 100 discussed above. Conversely, the first description configuration is more complicated, because it is compatible with all catheters and is universal.
通过将所有不同的功能提供在一个紧凑型系统中，可以将流体喷注系统1800用于多种情况。一般的喷注系统或者是高压的或者是低压的，所以这两套系统医务人员必须都要拥有，而且都要能够使用。通过对系统进行组合。通过组合系统，喷注器系统1800更容易使用，因为装置最小化且学习曲线减少。另外的有益效果包括节省时间、减少消耗，不占用另外的地面空间以及对于任何手术的装置可用性。By providing all the different functions in one compact system, the fluid injection system 1800 can be used in a variety of situations. The general injection system is either high-pressure or low-pressure, so medical personnel must have both systems and be able to use them. By combining the system. By combining the systems, the injector system 1800 is easier to use because the equipment is minimized and the learning curve is reduced. Additional benefits include time savings, reduced costs, no additional floor space taken up, and device availability for any procedure.
参考图12B，喷注器系统1900可以包括上文所讨论的喷注器系统1800的所有特征，以及那些未被讨论的特征。类似地，也可以使用利用各种导管的相同多用途配置。Referring to Figure 12B, injector system 1900 may include all of the features of injector system 1800 discussed above, as well as those not discussed. Similarly, the same multipurpose configuration utilizing various catheters can also be used.
这里，喷注器系统1900包括了多活塞泵1902，该多活塞泵1902能够输送在造影成像中使用的、冲洗液中使用的，或者与上述的血栓切除术导管100一起使用的低压流体1904。进一步地，多活塞泵1904可以输送与标准血栓切除术导管一起使用高压流体1908。Here, injector system 1900 includes a multi-piston pump 1902 capable of delivering low-pressure fluid 1904 for use in contrast imaging, for irrigation, or for use with the thrombectomy catheter 100 described above. Further, multi-piston pump 1904 can deliver high pressure fluid 1908 for use with standard thrombectomy catheters.
再次，通过将所有不同的功能提供在一个紧凑型系统中，可以将流体喷注系统1900用于多种情况。一般的喷注系统或者是高压的或者是低压的，所以这两套系统医务人员必须都要拥有，而且都要能够使用。通过组合系统，喷注器系统1900更容易使用，因为装置最小化且学习曲线减少。另外的有益效果包括节省时间、减少消耗，不占用另外的地面空间以及对于任何手术的装置可用性。Again, by providing all the different functions in one compact system, the fluid injection system 1900 can be used in a variety of situations. The general injection system is either high-pressure or low-pressure, so medical personnel must have both systems and be able to use them. By combining the systems, the injector system 1900 is easier to use because the equipment is minimized and the learning curve is reduced. Additional benefits include time savings, reduced costs, no additional floor space taken up, and device availability for any procedure.
血栓切除术导管Thrombectomy Catheters
图13A示出了根据本公开一个或者多个实施例所述的血栓切除术导管2000的实施例的侧视图。血栓切除术导管2000一般包括导管本体2002，所述导管本体2002包括抽吸腔2052(参见图14和15)，所述抽吸腔2052延伸穿过导管本体2002，并在远端的抽吸孔2005处开口。例如使用止血阀、配件等，抽吸腔2052与抽吸端口2004连通，所述抽吸端口2004可以连接到上文所讨论的真空源。真空源包括但不限于注射器、真空瓶、滚柱泵、真空泵等。血栓切除术导管2000包括流体喷注端口2007(类似地包括止血阀、配件等)。在该例子中，流体能够穿过灌注本体2008传输，所述灌注本体2008可以是不锈钢海波管、高分子管、镍钛诺管等。灌注本体2008可以包括连接到喷注器源的连接元件2030，所述喷注器源可以是上文所讨论的喷注器。灌注本体包括内腔，所述内腔穿过灌注本体延伸并且在导管远端部分2016附近具有灌注孔2010。在一个例子中使用单灌注孔2010。灌注本体在抽吸腔2052内穿过导管本体2002延伸。FIG. 13A illustrates a side view of an embodiment of a thrombectomy catheter 2000 according to one or more embodiments of the present disclosure. The thrombectomy catheter 2000 generally includes a catheter body 2002 including a suction lumen 2052 (see FIGS. 14 and 15 ) extending through the catheter body 2002 and a suction hole at the distal end. Opened in 2005. The suction lumen 2052 communicates with a suction port 2004, which may be connected to a vacuum source as discussed above, eg, using a hemostatic valve, fitting, or the like. Vacuum sources include, but are not limited to, syringes, vacuum bottles, roller pumps, vacuum pumps, and the like. The thrombectomy catheter 2000 includes a fluid injection port 2007 (similarly including a hemostatic valve, fittings, etc.). In this example, fluid can be delivered through an irrigation body 2008, which may be a stainless steel hypotube, polymer tube, nitinol tube, or the like. Irrigation body 2008 may include connection element 2030 to connect to an injector source, which may be the injector discussed above. The irrigation body includes a lumen extending therethrough and having an irrigation hole 2010 near the catheter distal portion 2016 . In one example a single perfusion hole 2010 is used. The irrigation body extends through catheter body 2002 within aspiration lumen 2052 .
图13A进一步示出了穿过导管本体2002延伸的导丝2066以及扩张元件(2020,下文进行描述)。导丝2066有助于导航穿过脉管系统，并且进一步考虑到了在维持灌注本体2008(和扩张元件)相对于导管本体2002的一致性时，血栓切除术导管的所述部件相对于彼此的滑动移动。如图13A中所示，导丝2066穿过歧管2012延伸，所述歧管2012与导管近端部分2018连接。导丝2066穿过进入端口2014进入歧管2012。和其他端口，包括抽吸端口2004和流体喷注端口2007一样，为了有助于穿过多支管2012的导丝2066的密封传输，止血阀可选择地设置在进入端口2014。设置在血栓切除术导管2000内的密封环境考虑到了从灌注本体2008和导管远端端口2016(例如，紧邻抽吸孔2005处的扩张元件2020)抽吸包括夹带颗粒的灌注流体。FIG. 13A further illustrates guidewire 2066 extending through catheter body 2002 and expansion element ( 2020 , described below). Guide wire 2066 facilitates navigation through the vasculature and further allows for sliding of the components of the thrombectomy catheter relative to each other while maintaining conformity of perfusion body 2008 (and dilation element) relative to catheter body 2002 move. As shown in FIG. 13A , guidewire 2066 extends through manifold 2012 , which is connected to catheter proximal portion 2018 . Guidewire 2066 enters manifold 2012 through access port 2014 . As with other ports, including aspiration port 2004 and fluid infusion port 2007 , to facilitate sealed delivery of guidewire 2066 through manifold 2012 , a hemostatic valve is optionally provided at access port 2014 . The sealed environment provided within the thrombectomy catheter 2000 allows for aspiration of perfusion fluid, including entrained particles, from the perfusion body 2008 and catheter distal port 2016 (eg, expansion element 2020 proximate to aspiration aperture 2005).
扩张元件2020连接到灌注本体2008的远端，并且位于远离灌注孔的那一端。图13B中示出的是扩张元件2020的细节横剖视图。扩张元件2020的直径大于灌注本体2008。在一个例子中扩张元件2020的尺寸可以装进抽吸孔2005。在一个例子中，扩张元件2020包括锥形的远端部分2035以及一个或者多个标记环2022。在一些例子中，扩张元件2020包括胶球或者另外的线圈。在其他的例子中，抽吸腔2052包括了例如图3和4中所示的加宽的抽吸孔远端元件114。可选择地，扩张元件2020靠近近端的部分为锥形以有助于输送进抽吸孔2005。Expansion element 2020 is connected to the distal end of irrigation body 2008 and is located at the end remote from the irrigation hole. A detailed cross-sectional view of expansion element 2020 is shown in FIG. 13B . The expansion element 2020 has a larger diameter than the irrigation body 2008 . The expansion element 2020 is sized to fit into the suction hole 2005 in one example. In one example, expansion element 2020 includes a tapered distal portion 2035 and one or more marker rings 2022 . In some examples, expansion element 2020 includes a rubber bulb or another coil. In other examples, the suction lumen 2052 includes a widened suction hole distal element 114 such as shown in FIGS. 3 and 4 . Optionally, the portion of the expansion element 2020 near the proximal end is tapered to facilitate delivery into the aspiration hole 2005 .
如图13B中进一步所示，扩张元件2020包括了尺寸和形状可以容纳灌注本体远端2062(例如，海波管的远端提供灌注流体到流体灌注孔2010)的灌注本体凹部2060。在一个例子中，灌注本体远端2062使用至少一个机构与扩张元件固定连接，所述机构包括但不限于灌注本体凹部2060内的粘合剂、压接、包注模(overmolding)、机械过盈配合等。在另一个例子中，扩张元件2020的尺寸和形状可以接受器械的滑动，所述器械例如导丝通道2064内的导丝。在图13B中，导丝2066显示穿过扩张元件2020延伸。可选择地，如图所示导丝通道2064包括至少部分非直线的通道，所述非直线的通道包括例如弯头2068。在另一个选择中，导丝通道2064位于扩张元件2020内基本上中心的位置。以导丝2066作为轨道，扩张元件2020搭着导丝2066行进。还是在另一个例子中，导丝通道设置在灌注本体2008内，因此以相同的构造结合导丝和灌注本体2008。As further shown in FIG. 13B , expansion element 2020 includes an irrigation body recess 2060 sized and shaped to receive irrigation body distal end 2062 (eg, the distal end of the hypotube providing irrigation fluid to fluid infusion hole 2010 ). In one example, the irrigation body distal end 2062 is fixedly coupled to the expansion element using at least one mechanism, including but not limited to adhesives within the irrigation body recess 2060, crimping, overmolding, mechanical interference Cooperate and so on. In another example, expansion member 2020 is sized and shaped to accept sliding of an instrument, such as a guidewire within guidewire channel 2064 . In FIG. 13B , guidewire 2066 is shown extending through expansion element 2020 . Optionally, as shown, guidewire channel 2064 includes an at least partially non-linear channel including, for example, an elbow 2068 . In another option, guidewire channel 2064 is located substantially centrally within expansion member 2020 . With the guide wire 2066 as a track, the expansion element 2020 is advanced over the guide wire 2066 . In yet another example, a guidewire channel is provided within irrigation body 2008, thus combining the guidewire and irrigation body 2008 in the same configuration.
扩张元件2020可以配置用来解除卡在抽吸孔2005内的物质堵塞物2050。例如，如图14所示，血栓堵塞物2050塞在血栓切除术导管2000的顶端2040。如图15所示，拉回灌注本体2008(反过来说就是导管顶端2040经过扩张元件2020移动前进)可以解除堵塞，因此不需要从体内移动导管就可以恢复抽吸。可选择地，扩张元件2020和灌注本体2008可从导管本体2002内移动，例如通过灌注本体2008相对于导管本体的近端滑动或者远端滑动。还是在另一个例子中，扩张元件2020和灌注本体2008可以设置成单一的装置，所述装置的尺寸和形状可以与一个或者多个标准传输导管或者标准介入导管一起使用，这些导管具有大小可以收纳灌注本体2008和扩张元件2020的内腔。Expansion element 2020 may be configured to release blockage 2050 of material lodged within aspiration aperture 2005 . For example, as shown in FIG. 14 , a thrombus plug 2050 is plugged into the tip 2040 of the thrombectomy catheter 2000 . As shown in FIG. 15, pulling back on the irrigation body 2008 (and in turn, movement of the catheter tip 2040 past the dilating element 2020) unblocks the blockage so that suction can resume without moving the catheter from the body. Optionally, expansion element 2020 and irrigation body 2008 are movable from within catheter body 2002, such as by proximal or distal sliding of irrigation body 2008 relative to the catheter body. In still another example, the expansion element 2020 and the perfusion body 2008 can be provided as a single device sized and shaped for use with one or more standard delivery catheters or standard interventional catheters sized to receive The lumen of body 2008 and expansion element 2020 are perfused.
在操作中，血栓塞入抽吸孔2005。使用者通过朝着任一方向(顺时针或者逆时针)一次或者多次旋转灌注本体2008以及通过相对于导管本体2002纵向往复移动灌注本体来操纵灌注本体2008。正如图14和15所示，扩张元件2020作为滑动元件相对于导丝2066移动，所述导丝2066收纳在导丝通道2064中。相应地导丝2066用作扩张元件2020的轨道。导丝2066，也可以收纳在抽吸腔2052中，用来协助扩张元件2020中心对准抽吸腔2052。In operation, a thrombus is plugged into the aspiration port 2005 . The user manipulates the irrigation body 2008 by rotating the irrigation body 2008 one or more times in either direction (clockwise or counterclockwise) and by reciprocating the irrigation body longitudinally relative to the catheter body 2002 . As shown in FIGS. 14 and 15 , dilation element 2020 moves as a sliding element relative to guidewire 2066 received in guidewire channel 2064 . Correspondingly guide wire 2066 serves as a track for expansion element 2020 . A guide wire 2066 may also be received in the suction lumen 2052 to assist in centering the expansion element 2020 with the suction lumen 2052 .
当扩张元件2020在抽吸腔2052内时，扩张元件2020实际上推动(例如，塞入、机械结合等)血栓2050进入到抽吸腔2052并且顺着抽吸腔2052而下。同时，灌注孔2010位于导管本体2002的抽吸腔2052内，并且灌注射流2054协助击碎血栓2050。扩张元件2020用作抽吸孔2005的插塞，而灌注射流将指向堵塞的血栓，并且从灌注口2010流出的灌注射流2054将带着血栓穿过抽吸腔2052。换句话说，灌注孔2010和所生成的灌注射流2054与由扩张元件所提供的机械结合(例如，插入)相配合来移除抽吸孔2005处和抽吸腔2052内的物质堵塞物2050。这种组合功能可以最小化并且基本上消除抽吸腔2052的堵塞，即使穿过灌注孔2010所输送的是低压灌注流体。When dilation element 2020 is within aspiration lumen 2052 , dilation element 2020 actually pushes (eg, plugs, mechanically binds, etc.) thrombus 2050 into aspiration lumen 2052 and down aspiration lumen 2052 . Meanwhile, the perfusion hole 2010 is located within the suction lumen 2052 of the catheter body 2002 , and the perfusion fluid 2054 assists in crushing the thrombus 2050 . The expansion element 2020 acts as a plug for the aspiration hole 2005, while the perfusion fluid will be directed at the blocked thrombus, and the perfusion fluid 2054 from the perfusion port 2010 will carry the thrombus through the aspiration lumen 2052. In other words, perfusion aperture 2010 and generated perfusion infusion flow 2054 cooperate with the mechanical engagement (eg, insertion) provided by the dilation element to remove material blockage 2050 at aspiration aperture 2005 and within aspiration lumen 2052 . This combined function can minimize and substantially eliminate clogging of the aspiration lumen 2052 even though low pressure perfusion fluid is being delivered through the perfusion holes 2010 .
在本例中，扩张元件2020与导管本体2002的配合可以在去除血栓2050中放弃使用如上文所述的加宽抽吸孔远端元件114。这使得装置可以平滑地穿过堵塞和脉管系统而不会造成栓塞或血管破坏。在一些例子中，加宽抽吸孔远端元件114也可以与扩张元件2020一起使用。In this example, the cooperation of the expansion element 2020 with the catheter body 2002 can eliminate the use of the widening suction hole distal element 114 in removing the thrombus 2050 as described above. This allows the device to pass smoothly through blockages and vasculature without embolism or vessel damage. In some examples, the widening suction hole distal element 114 may also be used with the expansion element 2020 .
附注notes
上文的详细描述参考了附图，这些附图也座位详细描述的一部分。通过示例的方式，附图示出了具体的实施例，在这些实施例中能够实施本发明。这些实施例本文中也称为“例子”。这些例子可以包括除示出或者描述以外的其他元件。然而本发明的发明人也接受仅提供那些所示出元件或者所描述元件的例子。此外，本发明的发明人也接受对示出或者描述元件进行任意组合或者交换的例子(或者这些例子的一个或者多个方面)，或者关于特定的例子(或者这些例子的一个或者多个方面)，或者关于本文所示出或者所描述的其他例子(或者其他例子的一个或者多个方面)。The above detailed description refers to the accompanying drawings, which also form a part of the detailed description. By way of example, the drawings show specific embodiments in which the invention can be practiced. These embodiments are also referred to herein as "Examples." These examples may include other elements than those shown or described. However, the inventors of the present invention also accept that only those elements shown or described are examples. In addition, the inventors of the present invention also accept examples (or one or more aspects of these examples) of any combination or exchange of shown or described elements, or about specific examples (or one or more aspects of these examples) , or with respect to other examples (or one or more aspects of other examples) shown or described herein.
本文所涉及的所有出版物、专利以及专利文件全部纳入本文作为参考，就像它们单独纳入作为参考一样。在本文件与上述文件之间使用不一致的情况下应该这样纳入作为参考，所纳入参考的使用应该看作是对本文件的补充；对于不能调和的不一致，使用本文件。All publications, patents, and patent documents mentioned herein are hereby incorporated by reference in their entirety as if individually incorporated by reference. In the event of usage inconsistencies between this document and the above-mentioned documents, such use shall be incorporated by reference, and the use of the incorporated reference shall be considered in addition to this document; for irreconcilable inconsistencies, this document shall apply.
在本文件中，所使用的术语“a”或“an”，和一般的专利文件一样，包括一个或者一个以上，独立于“atleastone”或者“oneormore”的任何例子或者使用。本文件中，属于“or”用来指非排他的情况，例如“AorB”包括“AbutnotB”、“BbutnotA”以及“AandB”，除非另有说明。在后附的权利要求书中，术语“including”和“inwhich”用作简单易懂的英语，分别等于术语“comprising”和“wherein”。同样的，在下面的权利要求书中，术语“including”和“comprising”是开放的，也就是说，包括了除这些术语后所列出元件以外元件的系统、装置、物品或者工艺也落入到权利要求的保护范围之内。此外，在下面的权利要求中，术语“first”、“second”和“third”等仅仅用作标签，不打算对它们的目标强加数字要求。In this document, the term "a" or "an" is used, as in general patent documents, to include one or more, independent of any instance or use of "atleastone" or "oneormore". In this document, "or" is used to refer to non-exclusive cases, eg "AorB" includes "AbutnotB", "BbutnotA" and "AandB", unless otherwise stated. In the appended claims, the terms "including" and "inwhich" are used in plain English to be equivalent to the terms "comprising" and "wherein", respectively. Likewise, in the following claims, the terms "including" and "comprising" are open-ended, meaning that a system, apparatus, article, or process that includes elements other than those listed after these terms also falls within the scope of the claims. within the scope of protection of the claims. Furthermore, in the following claims, the terms "first", "second", and "third", etc. are used merely as labels and are not intended to impose numerical requirements on their objectives.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2014/031299WO2014127389A2 (en) | 2013-02-13 | 2014-03-20 | Thrombectomy catheter |
| Publication Number | Publication Date |
|---|---|
| CN105120776Atrue CN105120776A (en) | 2015-12-02 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480020975.9APendingCN105120776A (en) | 2014-03-20 | 2014-03-20 | Thrombectomy catheter |
| Country | Link |
|---|---|
| CN (1) | CN105120776A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468306A (en)* | 2017-08-15 | 2017-12-15 | 南京普微森医疗科技有限公司 | A kind of thrombus suction catheter |
| CN111616802A (en)* | 2020-05-15 | 2020-09-04 | 上海交通大学 | Ultrafine magnetically controlled flexible robot based on polymer flexible microtubes |
| CN113350655A (en)* | 2016-02-24 | 2021-09-07 | 禾木（中国）生物工程有限公司 | Neurovascular catheter with enhanced flexibility |
| CN113876283A (en)* | 2021-09-17 | 2022-01-04 | 深圳英美达医疗技术有限公司 | Multi-cavity tube with gradually-changed hardness, manufacturing method and device and endoscope |
| US11553935B2 (en) | 2019-12-18 | 2023-01-17 | Imperative Care, Inc. | Sterile field clot capture module for use in thrombectomy system |
| US11766539B2 (en) | 2019-03-29 | 2023-09-26 | Incept, Llc | Enhanced flexibility neurovascular catheter |
| US11819228B2 (en) | 2019-12-18 | 2023-11-21 | Imperative Care, Inc. | Methods and systems for treating a pulmonary embolism |
| US11850349B2 (en) | 2018-07-06 | 2023-12-26 | Incept, Llc | Vacuum transfer tool for extendable catheter |
| US12042160B2 (en) | 2018-05-01 | 2024-07-23 | Incept, Llc | Catheter having angled tip |
| US12171917B1 (en) | 2024-01-08 | 2024-12-24 | Imperative Care, Inc. | Devices for blood capture and reintroduction during aspiration procedure |
| US12201506B2 (en) | 2019-12-18 | 2025-01-21 | Imperative Care, Inc. | Rotatable thrombus engagement tool |
| US12232838B2 (en) | 2021-08-12 | 2025-02-25 | Imperative Care, Inc. | Method of robotically performing a neurovascular procedure |
| USD1077996S1 (en) | 2021-10-18 | 2025-06-03 | Imperative Care, Inc. | Inline fluid filter |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060129091A1 (en)* | 2004-12-10 | 2006-06-15 | Possis Medical, Inc. | Enhanced cross stream mechanical thrombectomy catheter with backloading manifold |
| US7141045B2 (en)* | 2000-03-20 | 2006-11-28 | Corazon Technologies, Inc. | Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same |
| US20070161963A1 (en)* | 2006-01-09 | 2007-07-12 | Smalling Medical Ventures, Llc | Aspiration thrombectomy catheter system, and associated methods |
| US20110213393A1 (en)* | 2007-12-20 | 2011-09-01 | Vortex Medical, Inc. | Systems and Methods for Removing Undesirable Material Within a Circulatory System Utilizing a Balloon Catheter |
| CN103068435A (en)* | 2010-08-12 | 2013-04-24 | C·R·巴德股份有限公司 | Trimmable catheter including distal portion stability features |
| US20130165944A1 (en)* | 2011-12-15 | 2013-06-27 | The Board Of Trustees Of The Leland Stanford Jr. University | Apparatus, systems, and methods for removing obstructions in the urinary tract |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7141045B2 (en)* | 2000-03-20 | 2006-11-28 | Corazon Technologies, Inc. | Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same |
| US20060129091A1 (en)* | 2004-12-10 | 2006-06-15 | Possis Medical, Inc. | Enhanced cross stream mechanical thrombectomy catheter with backloading manifold |
| EP2520322A2 (en)* | 2004-12-10 | 2012-11-07 | Medrad, Inc. | Enhanced cross stream mechanical thrombectomy catheter with backloading manifold |
| US20070161963A1 (en)* | 2006-01-09 | 2007-07-12 | Smalling Medical Ventures, Llc | Aspiration thrombectomy catheter system, and associated methods |
| US20110213393A1 (en)* | 2007-12-20 | 2011-09-01 | Vortex Medical, Inc. | Systems and Methods for Removing Undesirable Material Within a Circulatory System Utilizing a Balloon Catheter |
| CN103068435A (en)* | 2010-08-12 | 2013-04-24 | C·R·巴德股份有限公司 | Trimmable catheter including distal portion stability features |
| US20130165944A1 (en)* | 2011-12-15 | 2013-06-27 | The Board Of Trustees Of The Leland Stanford Jr. University | Apparatus, systems, and methods for removing obstructions in the urinary tract |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113350655A (en)* | 2016-02-24 | 2021-09-07 | 禾木（中国）生物工程有限公司 | Neurovascular catheter with enhanced flexibility |
| US12343479B2 (en) | 2016-02-24 | 2025-07-01 | Incept, Llc | Neurovascular catheter |
| CN113350655B (en)* | 2016-02-24 | 2024-03-19 | 禾木（中国）生物工程有限公司 | Nerve vascular catheter with enhanced flexibility |
| CN107468306A (en)* | 2017-08-15 | 2017-12-15 | 南京普微森医疗科技有限公司 | A kind of thrombus suction catheter |
| US12042160B2 (en) | 2018-05-01 | 2024-07-23 | Incept, Llc | Catheter having angled tip |
| US11850349B2 (en) | 2018-07-06 | 2023-12-26 | Incept, Llc | Vacuum transfer tool for extendable catheter |
| US11766539B2 (en) | 2019-03-29 | 2023-09-26 | Incept, Llc | Enhanced flexibility neurovascular catheter |
| US12350443B2 (en) | 2019-03-29 | 2025-07-08 | Incept, Llc | Enhanced flexibility neurovascular catheter |
| US11633272B2 (en) | 2019-12-18 | 2023-04-25 | Imperative Care, Inc. | Manually rotatable thrombus engagement tool |
| US11819228B2 (en) | 2019-12-18 | 2023-11-21 | Imperative Care, Inc. | Methods and systems for treating a pulmonary embolism |
| US11638637B2 (en) | 2019-12-18 | 2023-05-02 | Imperative Care, Inc. | Method of removing embolic material with thrombus engagement tool |
| US12201506B2 (en) | 2019-12-18 | 2025-01-21 | Imperative Care, Inc. | Rotatable thrombus engagement tool |
| US11553935B2 (en) | 2019-12-18 | 2023-01-17 | Imperative Care, Inc. | Sterile field clot capture module for use in thrombectomy system |
| CN111616802A (en)* | 2020-05-15 | 2020-09-04 | 上海交通大学 | Ultrafine magnetically controlled flexible robot based on polymer flexible microtubes |
| US12232838B2 (en) | 2021-08-12 | 2025-02-25 | Imperative Care, Inc. | Method of robotically performing a neurovascular procedure |
| US12376928B2 (en) | 2021-08-12 | 2025-08-05 | Imperative Care, Inc. | Catheter drive system for supra-aortic access |
| WO2023040232A1 (en)* | 2021-09-17 | 2023-03-23 | 深圳英美达医疗技术有限公司 | Multi-lumen tube having gradually changing hardness, manufacturing method, manufacturing apparatus, and endoscope |
| CN113876283A (en)* | 2021-09-17 | 2022-01-04 | 深圳英美达医疗技术有限公司 | Multi-cavity tube with gradually-changed hardness, manufacturing method and device and endoscope |
| USD1077996S1 (en) | 2021-10-18 | 2025-06-03 | Imperative Care, Inc. | Inline fluid filter |
| US12171917B1 (en) | 2024-01-08 | 2024-12-24 | Imperative Care, Inc. | Devices for blood capture and reintroduction during aspiration procedure |
| Publication | Publication Date | Title |
|---|---|---|
| CN105120776A (en) | Thrombectomy catheter | |
| US20140228869A1 (en) | Thrombectomy catheter | |
| US20170265885A1 (en) | Thrombectomy catheter system | |
| JP7514290B2 (en) | Systems and methods for thrombolysis and drug delivery - Patents.com | |
| US12150659B2 (en) | Systems and methods for removal of blood and thrombotic material | |
| US20220387052A1 (en) | Systems and methods for removal of blood and thrombotic material | |
| US12420060B2 (en) | Direct stream hydrodynamic catheter system | |
| JP7249945B2 (en) | Systems and methods for removing blood and thrombotic material | |
| US20240157041A1 (en) | Systems for aspirating and irrigating body cavities, and associated devices and methods | |
| US6558366B1 (en) | Thrombectomy method | |
| EP3157445A1 (en) | Thrombectomy catheter system | |
| WO2007143288A2 (en) | Systems for injecting media contrast | |
| JP2004535246A (en) | Liquid exchange system for local irrigation and aspiration while controlling liquid volume | |
| US20250204938A1 (en) | Thrombectomy catheters | |
| US20250186067A1 (en) | Clog clearance device for thrombectomy catheter | |
| US20250186066A1 (en) | Rotating jet for thrombectomy catheter | |
| US20210121675A1 (en) | Systems, Devices, and Methods For Thrombolysis | |
| AU725925B2 (en) | Thrombectomy method and device | |
| AU5361200A (en) | Thrombectomy method and device |
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | Application publication date:20151202 | |
| WD01 | Invention patent application deemed withdrawn after publication |