A kind of even pressure microneedle configurationTechnical field
The present invention relates to medical and beauty treatment health-care material field, especially, is a kind of even pressure microneedle configuration.
Background technology
Beauty treatment micropin utilizes many small syringe needles on micropin roller, chafe, and within very short time, micropin can be made more than 200,000 microtubule, by the regeneration of stimulation collagen, reaches the object of beauty treatment.Along with the development of micro-processing technology, a kind ofly sting expelling pathogenic factors from the exterior skin but do not injure corium and neural micropin technology was come out, for transdermal administration brings new thinking before the more than ten years.Size pierces through the skin surface (horny layer) of permeability extreme difference at micron-sized micropin dot matrix in the mode of reversible Wicresoft, causes biomacromolecule to be able to the mechanical passage passed through, and does not but produce pain and skin trauma.Thrust preferably to change skin permeation sexuality though conventional metals, glass, siliceous micropin possess, but generally medicine is applied in microneedle surface, drug loading is little, is difficult to reach therapeutic effect.Therefore, there is the empty micropin structure of coating medicine in micropin inside, the medicine of q.s can be made to enter the skin corium of skin by empty micropin.But general microneedle configuration adopts the mode of pressing type mostly, enter skin corium after extruding to medicine, such mode, very easily cause local to infiltrate too much, very few situation is infiltrated in local, affects the absorption of medicine.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of even pressure microneedle configuration, what this even pressure microneedle configuration can make medicaments uniformity enters skin corium.
The technical solution adopted for the present invention to solve the technical problems is:
This even pressure microneedle configuration comprises base material, described base material is pressed array and is protruded and the hollow microneedles of formation to side, the opposite side of described base material is provided with closed film, moisture self-restraint layer is provided with between described closed film and base material, the root of described hollow microneedles is provided with imbibition swollen material, described base material is provided with the sealing coat of sealing imbibition swollen material, described closed film there is the needle-like portion puncturing described sealing coat, in described hollow microneedles, be provided with the medicament capsule adapted with described imbibition swollen material.
As preferably, described imbibition swollen material is fibroin albumen imbibition swollen material.
As preferably, in described moisture self-restraint layer, be provided with moisture-retaining material.
As preferably, between described imbibition swollen material and medicament capsule, be provided with colloid separate layer.
As preferably, in described colloid separate layer, be provided with the globular solids that diameter is less than hollow microneedles outlet.
The invention has the advantages that:
Press described closed film, needle-like portion punctures described sealing coat, moisture enters described imbibition swollen material, and imbibition swollen material expands and ejects to skin corium by medicament capsule, during owing to manufacturing, namely the amount of the imbibition swollen material in each hollow microneedles has been determined, therefore, as long as puncture sealing coat, the volume that imbibition swollen material expands is all consistent, uniform thus medicament is injected into skin corium, improves the absorbance of medicament.Meanwhile, adopt fibroin albumen as imbibition swollen material, even if imbibition swollen material is excessive and eject hollow microneedles because of error, reveals in skin corium, because the human compatibility of fibroin albumen, can be absorbed easily by human body, improve the safety used.
Accompanying drawing explanation
Fig. 1 be this even pressure microneedle configuration face generalized section.
Fig. 2 faces generalized section after this even pressure microneedle configuration pressing.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is further described:
In the present embodiment, consult Fig. 1, this even pressure microneedle configuration comprises base material 110, described base material 110 is pressed array and is protruded and the hollow microneedles 100 of formation to side, the opposite side of described base material 110 is provided with closed film 400, moisture self-restraint layer 500 is provided with between described closed film 400 and base material 110, the root of described hollow microneedles 100 is provided with imbibition swollen material 300, described base material 110 is provided with the sealing coat 310 of sealing imbibition swollen material 300, described closed film 400 there is the needle-like portion 410 puncturing described sealing coat, the medicament capsule 10 adapted with described imbibition swollen material 300 is provided with in described hollow microneedles 100.
Above-mentioned even pressure microneedle configuration, described imbibition swollen material 300 is fibroin albumen imbibition swollen material, and fibroin albumen, as imbibition swollen material, even if produce excessive expansion and reveal, also can ensure the safety of human body.
Above-mentioned even pressure microneedle configuration, is provided with moisture-retaining material in described moisture self-restraint layer 500.
Described moisture-retaining material can adopt netted sponge structure, both can keep moisture, can make again closed film 400 resilience after being pressed.
Above-mentioned even pressure microneedle configuration, colloid separate layer 200 is provided with between described imbibition swollen material 300 and medicament capsule 10, described colloid separate layer can adopt medical grade silicone to make, and separate layer can prevent imbibition swollen material 300 to be mixed into medicament capsule 10, and then affects its quality.
Above-mentioned even pressure microneedle configuration, is provided with the globular solids 210 that diameter is less than hollow microneedles outlet in described colloid separate layer 200.
The use principle of the even pressure microneedle configuration in two above-mentioned embodiments:
Consult Fig. 2, press described closed film 400, needle-like portion 410 punctures described sealing coat 310, moisture enters described imbibition swollen material 300, imbibition swollen material 300 expands and ejects to skin corium by medicament capsule 10, because the imbibition swollen material 300 that exists of globular solids 210 is limited in hollow microneedles 100.
Describedly be only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included in protection scope of the present invention.