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CN104784311B - Composition of medicine for preventing and treating animal aphtha hoof Huang and preparation method thereof - Google Patents

Composition of medicine for preventing and treating animal aphtha hoof Huang and preparation method thereof
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CN104784311B
CN104784311BCN201510129031.1ACN201510129031ACN104784311BCN 104784311 BCN104784311 BCN 104784311BCN 201510129031 ACN201510129031 ACN 201510129031ACN 104784311 BCN104784311 BCN 104784311B
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parts
hoof
aphtha
huang
root
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CN104784311A (en
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胡进成
王之丽
杨军
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Sichuan Cheng Kang Animal Pharmaceutical Estate Co Ltd
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Sichuan Cheng Kang Animal Pharmaceutical Estate Co Ltd
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Abstract

The invention discloses a kind of composition of medicine for being used to prevent and treat animal aphtha hoof Huang, including:Include the bulk drug of following parts by weight meter:12 parts of root of Chinese trichosanthes, 12 parts of akebi, 23 parts of radix scutellariae, 23 parts of the coptis, 12 parts of the capsule of weeping forsythia, 12 parts of Poria cocos, 12 parts of golden cypress, 12 parts of balloonflower root, 12 parts of the root of Dahurain angelica, 12 parts of cape jasmine, 12 parts of the root of kudzu vine, 12 parts of cicada slough, 23 parts of great burdock achene, 12 parts of indigo naturalis, 12 parts of frankincense.The invention provides unified medicament composing prescription, can deal with jumpbogroup animal aphtha hoof Huang disease, and simple to operate, manufactured pulvis and jodine glycerin are used in conjunction with, the aphtha hoof Huang diseases that can cure animal in 23 days.The invention provides the preparation method and its usage of the composition of medicine for preventing and treating animal aphtha hoof Huang.

Description

Composition of medicine for preventing and treating animal aphtha hoof Huang and preparation method thereof
Technical field
The invention belongs to veterinary drug clinical practice field.It is more particularly related to a kind of be used to prevent and treat animal aphthaHoof Huang composition of medicine and preparation method thereof.
Background technology
In recent years, the disease incidence probability in terms of animal aphtha hoof Huang is higher, and the disease in terms of animal aphtha hoof Huang includesThe disease such as the stomatitis of pig, cattle and sheep, swine pox, sheep pox, infectiousness aphtha and hoof nail are festered, vesiculovirus rash.The country faces in Chinese veterinarianBed aspect, many experiences are have accumulated, wherein boil on the nape, hoof Huang has very strong Chinese veterinarian's theory basis, finds main cause of causing a diseaseDiseases caused by external factors six external factors which cause diseases dryness-heat, internal organs internal injury, its important pathomechanism is that heat is stopped up stasis, combination of phlegm and heat and heart heat and got angry, leak inLip, skin, hoof nail, its heat are sent out in table to festering.It is actually that the fire of interior heat is led off in outer performance.Especially in artiodactyl institute" tiger heart " of performance which illustrates this point.At present, more using liquid Acupuncture therapy, but antipyretic, antibacterial, analgesic effect be can only achieveFruit, and in terms of Chinese medicine, because clinical syndrome differentiation is complicated, jumpbogroup morbidity can not be tackled, and its prescription is various, can not unify, it is difficult to operatesThe shortcomings of.The problem of therefore a kind of unified Chinese prescription is provided and be urgent need to resolve for the solution of jumpbogroup medication.
The content of the invention
It is an object of the invention to solve at least the above and defect, and provide the advantages of at least will be described later.
In order to realize according to object of the present invention and further advantage, there is provided one kind is used to prevent and treat animal aphtha hoof HuangComposition of medicine, include the bulk drug of following parts by weight meter:Root of Chinese trichosanthes 1-2 parts, akebi 1-2 parts, radix scutellariae 2-3 parts, coptis 2-3Part, capsule of weeping forsythia 1-2 parts, Poria cocos 1-2 parts, golden cypress 1-2 parts, balloonflower root 1-2 parts, root of Dahurain angelica 1-2 parts, cape jasmine 1-2 parts, root of kudzu vine 1-2 parts, cicada slough1-2 parts, great burdock achene 2-3 parts, indigo naturalis 1-2 parts, frankincense 1-2 parts, the wherein coptis, radix scutellariae, golden cypress, the logical fire for rushing down three Jiao of cape jasmine, leadHeat is descending, is main ingredient;It is aided with the capsule of weeping forsythia and helps main ingredient purging intense heat and detonicating;Great burdock achene, root of Dahurain angelica swelling and pain relieving, fushen's tranquilizing mind, root of Chinese trichosanthes are clearHeat is promoted the production of body fluid, and akebi clearing away the heart-fire, diuresis, root of kudzu vine cicada slough solve evil poison thoroughly, is all adjutant;Balloonflower root, indigo naturalis, frankincense apocenosis detumescence, myogenicAnalgesic, and carry and sick institute is reached on medicine, to make medicine.All medicines share, purging intense heat and detonicating, the effect of eliminating stasis to subdue swelling are played altogether.
Preferably, wherein, the bulk drug is 1 part of root of Chinese trichosanthes, 1 part of akebi, 2 parts of radix scutellariae, Huang respectively in parts by weight2 parts of company, 1 part of the capsule of weeping forsythia, 1 part of Poria cocos, 1 part of golden cypress, 1 part of balloonflower root, 1 part of the root of Dahurain angelica, 1 part of cape jasmine, 1 part of the root of kudzu vine, 1 part of cicada slough, great burdock achene 21 part of part, 1 part of indigo naturalis and frankincense, using unified prescription medicine, easily operation.
Preferably, wherein, its formulation is pulvis, and such a method improves the quality of Chinese medicine, improves the utilization rate of Chinese medicine,During use, micro-powder of Chinese herbs rapid dispersion and suspends in water, is normally drunk for poultry through automatic drinking water apparatus, effectively solves medicineThing precipitate and dosage it is uneven and the problem of cause drug effect to reduce.
Preferably, wherein, the preparation method of the pulvis:Each raw material will be made to the powder of 80-200 mesh after mixingEnd, then Ultramicro-powder is made using nanon ball-mill in described powder, superfine communication technique refers to and the theoretical mutually knot of traditional Chinese medicineClose, Chinese medicine, Chinese medical extract, Chinese medicine preparation, Chinese medicine preparation etc. are micronized, directly smashed the cell of Chinese medicine, due toAutonomic drug, the effective component of animal drugs are distributed mainly on into the cell and cytoplasm, based on intracellular, therefore will break Chinese medicineMaterial cell is " cellular level pulverizing " that purpose comminution process is referred to as Chinese medicine;The Chinese medicine obtained using cellular level pulverizing methodMicro mist is referred to as " cell grade micro-powder of Chinese herbs ";The Chinese medicine made based on cell grade micro-powder of Chinese herbs is referred to as " in cell grade micro mistMedicine ", it is referred to as " ultrafine Chinese herb ", effective to solve the problems, such as drug precipitation and dosage inequality and cause drug effect to reduce.
Preferably, wherein, the ultra-micro powder diameter is less than 10 microns, is easy to animal to reach drug administration by drinking-waterPurpose, the performance that Ultramicro-powder is advantageous to herbal medicine efficacy is made, reaches preferable therapeutic effect.
Preferably, wherein, the preparation method of the composition of medicine for preventing and treating animal aphtha hoof Huang, comprise the following steps:
Step 1: the bulk drug is dried to crisp, being mixed even is ground into 80-120 mesh powders;
Step 2: the powder obtained by step 1 is mixed into the saccharin sodium equivalent to the powder weight 0.1%-0.3%,Ultramicro-powder is made using nanon ball-mill;The diameter of wherein described Ultramicro-powder is less than 10 μm.
Preferably, wherein, for preventing and treating animal aphtha hoof Huang;Its application method is as follows:
A, when promptly preventing, used in drinking-water, added per 10L water and prepare Chinese medicine 50g, freely drunk.
When b, treating, added using every 1L water and prepare Chinese medicine 100g, every gavages 50ml, once a day, is used in conjunction 2-3 days.
The pulvis, adds that a small amount of saccharin sodium animal is acceptant to take, and is easily absorbed after taking, easy to operation,It is adapted to the prevention and treatment for big animal population animal aphtha hoof Huang.
Preferably, wherein, when being in a bad way, jodine glycerin is embrocated in cooperation, and the jodine glycerin is made of following steps:3 grams of KI, add 3 milliliters of distilled water, 1-3 grams of iodine added into the liquor kalii iodide, then add glycerine to 100 milliliters it is mixedTo close uniformly, the wound that sick aphthae, hoof casket fester outside heart thermic, easily by external environment microorganism infection, wound is not easy to heal,Jodine glycerin, which is made, cooperates with the pulvis to nurse use altogether, can make skin wound convergence healing, reach preferable therapeutic effect.
The present invention comprises at least following beneficial effect:
1st, the present invention have developed the composition of medicine for preventing and treating animal aphtha hoof Huang, there is provided unified medicament composing prescription, canIt is simple to operate to deal with jumpbogroup animal aphtha hoof Huang disease.
2nd, pulvis is made in the bulk drug by the present invention, realizes jumpbogroup medication, and can realize industrialized production.
3rd, pulvis of the invention is added to the water drinks for animal, and easy to operation, therapeutic effect is notable.
4th, pulvis and jodine glycerin of the invention are used in conjunction with, the aphtha hoof Huang diseases that can cure animal in 2-3 days.
Further advantage, target and the feature of the present invention embodies part by following explanation, and part will also be by thisThe research and practice of invention and be understood by the person skilled in the art.
Embodiment
The present invention is described in further detail below, to make those skilled in the art being capable of evidence with reference to specification wordTo implement.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or moreThe presence or addition of individual other elements or its combination.
For preventing and treating animal aphtha hoof Huang composition of medicine, include the bulk drug of following parts by weight meter:Root of Chinese trichosanthes 1-2 parts,Akebi 1-2 parts, radix scutellariae 2-3 parts, coptis 2-3 parts, capsule of weeping forsythia 1-2 parts, Poria cocos 1-2 parts, golden cypress 1-2 parts, balloonflower root 1-2 parts, root of Dahurain angelica 1-2Part, cape jasmine 1-2 parts, root of kudzu vine 1-2 parts, cicada slough 1-2 parts, great burdock achene 2-3 parts, indigo naturalis 1-2 parts, wherein frankincense 1-2 parts, the coptis, HuangThe logical fire for rushing down three Jiao of a kind of reed mentioned in ancient books, golden cypress, cape jasmine, heat conduction is descending, is main ingredient;It is aided with the capsule of weeping forsythia and helps main ingredient purging intense heat and detonicating;Great burdock achene, the root of Dahurain angelica disappearSwollen analgesic, fushen's tranquilizing mind, root of Chinese trichosanthes clearing heat and promoting fluid, akebi clearing away the heart-fire, diuresis, root of kudzu vine cicada slough solves evil poison thoroughly, is all adjutant;TangerineStalk, indigo naturalis, frankincense apocenosis detumescence, myogenic pain relieving, and carry and sick institute is reached on medicine, to make medicine.All medicines share, purging intense heat and detonicating is played altogether, dissipateThe swollen effect of stagnation resolvation.
In another example, the bulk drug is 1 part of root of Chinese trichosanthes, 1 part of akebi, 2 parts of radix scutellariae, Huang respectively in parts by weight2 parts of company, 1 part of the capsule of weeping forsythia, 1 part of Poria cocos, 1 part of golden cypress, 1 part of balloonflower root, 1 part of the root of Dahurain angelica, 1 part of cape jasmine, 1 part of the root of kudzu vine, 1 part of cicada slough, great burdock achene 21 part of part, 1 part of indigo naturalis and frankincense.
In another example, in the above-described embodiment, formulation made of the bulk drug is pulvis, and such a method changesThe quality of kind Chinese medicine, improve the utilization rate of Chinese medicine, in use, micro-powder of Chinese herbs rapid dispersion and suspends in water, through fromDynamic water dispenser is normally drunk for poultry, effective to solve the problems, such as drug precipitation and dosage inequality and cause drug effect to reduce..
In another example, in the above-described embodiment, the preparation method of the pulvis:Each raw material will be passed through into mixingAfter 80-200 mesh powders are made, then Ultramicro-powder is made using nanon ball-mill in described powder, uses nanon ball-millModel wi94924, superfine communication technique refer to be combined with traditional Chinese medicine theory, by Chinese medicine, Chinese medical extract, Chinese medicine systemAgent, Chinese medicine preparation etc. are micronized, and are directly smashed the cell of Chinese medicine, because the effective component of autonomic drug, animal drugs mainly dividesIt is distributed in into the cell and cytoplasm, based on intracellular, therefore Chinese medicine cell will be broken and be referred to as Chinese medicine for purpose comminution process" cellular level pulverizing ";The micro-powder of Chinese herbs obtained using cellular level pulverizing method is referred to as " cell grade micro-powder of Chinese herbs ";WithThe Chinese medicine made based on cell grade micro-powder of Chinese herbs is referred to as " cell grade ultrafine Chinese herb ", referred to as " ultrafine Chinese herb ", effective to solveDrug precipitation and dosage are uneven and the problem of cause drug effect to reduce.
In another example, in the above-described embodiment, the ultra-micro powder diameter is less than 10 microns, is easy to animal to lead toThe purpose that drinking-water reaches drug administration is crossed, the performance that Ultramicro-powder is advantageous to herbal medicine efficacy is made, reaches preferable therapeutic effect.
In another example, in the above-described embodiment, the preparation of the composition of medicine for preventing and treating animal aphtha hoof HuangMethod, comprise the following steps:
Step 1: the bulk drug is dried to crisp, being mixed even is ground into 80-120 mesh powders;
Step 2: the powder obtained by step 1 is mixed into the saccharin sodium equivalent to the powder weight 0.1%-0.3%,Ultramicro-powder is made using nanon ball-mill;The diameter of wherein described Ultramicro-powder is less than 10 μm.
In another example, in the above-described embodiment, for preventing and treating animal aphtha hoof Huang;Its application methodIt is as follows:
A, when promptly preventing, used in drinking-water, added per 10L water and prepare Chinese medicine 50g, freely drunk.
When b, treating, added using every 1L water and prepare Chinese medicine 100g, every gavages 50ml, once a day, is used in conjunction 2-3 days.
The pulvis, adds that a small amount of saccharin sodium animal is acceptant to take, and is easily absorbed after taking, easy to operation,It is adapted to the prevention and treatment for big animal population animal aphtha hoof Huang.
In another example, in the above-described embodiment, when being in a bad way, jodine glycerin is embrocated in cooperation, and the iodine is sweetOil is made of following steps:3 grams of KI, add 3 milliliters of distilled water, 1-3 grams of iodine is added into the liquor kalii iodide, thenGlycerine is added to 100 milliliters of well mixed, wounds that sick aphthae, hoof casket fester outside heart thermic, easily by the micro- life of external environmentThing infects, and wound is not easy to heal, and jodine glycerin is made and cooperates with the pulvis to nurse use altogether, can make skin wound convergence healing, reachTo preferable therapeutic effect.
In one of the embodiments, the present invention is used to prevent and treat animal aphtha hoof Huang composition of medicine and preparation method thereof:
(1), by 1 part of its equal portions root of Chinese trichosanthes, 1 part of akebi, 2 parts of radix scutellariae, 2 parts of the coptis, 1 part of the capsule of weeping forsythia, 1 part of Poria cocos, golden cypress 1Part, 1 part of balloonflower root, 1 part of the root of Dahurain angelica, 1 part of cape jasmine, 1 part of the root of kudzu vine, 1 part of cicada slough, 2 parts of great burdock achene, 1 part of indigo naturalis, 1 part of frankincense are first by raw materialMedicine is dried to crisp, and be mixed the even pulvis for being ground into 80~120 mesh.
(2) above-mentioned pulvis and appropriate saccharin sodium are added into micronizer and is smashed into Ultramicro-powder.Diameter is less than 10 μmThe industrial technology of the high-tech content of powder, have the characteristics that speed is fast, the time is short, particle diameter is thin, be evenly distributed, save raw material.
(3) 3 grams of KI in proportion, add 3 milliliters of aquae destillata, and glycerine is added extremely after dissolving plus after the fully dissolving of 1-3 grams of iodine100 milliliters mix produce it is standby.
In order to illustrate the effect of the present invention, it is as follows that inventor provides clinical practice experiment:
Experiment 1
In the clinical practice of oof disease
On March 13rd, 2014, Sichuan Province Mianyang City sheep raising family eruption and prevalence oof disease itself it is characterized in that mouthThe skin and mucous membrane of lip, bicker, nostril periphery etc. form papule, bubble or even purulence bubble, last ulceration and form excipuliform thickness scab, take offThere is the mouth that rubs by force after falling crust, searched for food when serious difficult, lassitude, body temperature rise, search for food and ruminate reduction, finallyExhaustion is dead.Especially lamb falls ill even more serious the most.According to clinical setting, decision uses the method.
(1) used in drinking-water, added per 10L water and prepare Chinese medicine 50g, freely drunk.
(2) serious milkfed lamb of falling ill is used to add per 1L water and prepares Chinese medicine 100g, every gavages 50ml.Once a day,It is used in conjunction 2-3 days,
(3) skin to lip, bicker, nostril periphery etc. and mucous membrane form papule, bubble or even purulence bubble and incrustationNigrescence etc. is scratched to form new ulcer surface with finger nail, embrocates above-mentioned special jodine glycerin, once a day.
Medication the 3rd day, the state of an illness does not make further progress, face convergence healing of festering, and healing is good.
Experiment 2
In the clinical practice of pig aphtha hoof anthrax
On January 15th, 2014,35, Liaoning Fuxin raiser pig farm sow (8 lactations), 135 growing and fattening pigs, have80 child care pigs, a night get up, and see that indivedual pig heatings are not eaten, are reluctant to move, the dead several heads of suckling piglet, next day further checks hairExisting, lip has bubble, and gum is red and swollen, tongue side bubble, swelling between hoof, stops when eating, and feed intake declines, and seems very painful sampleSon.The burning hot aphtha hoof anthrax of the heart channel of Hang-Shaoyin is diagnosed as according to clinical symptoms.Drinking-water dispensing treatment is carried out to the whole audience, dosage is everyTon water adds this product 5KG, and suckling piglet is gavaged, and hoof nail rotten position is applied and puts special jodine glycerin on the skin, basic health after medication three daysIt is multiple, swelling disappearance between oral cavity and hoof.Medication one week is maintained, in addition to dead 16 of suckling piglet, other whole rehabilitations are normally eaten food.In October, 2013 and in April, 2014 and May successively in several areas such as Liaoning new people, Liaozhong, Black Hills, the 3800 of ten Yu Jia pig farmsBull pig has carried out examination and controlled, as long as not going out after medication three, you can basic rehabilitation just with medicine of the present invention in premorbid 3 days.
Experiment 3
In the control and application of sheep pox
Its feature of sheep pox disease:Incubation period is 6~8 days, and sick sheep heating, body temperature rise is up to 40~42 DEG C, lassitude, appetiteDecline is not eaten, and disease just nostril occlusion, P&R are accelerated, and occasionally has cough, some goat stream slurries or mucus nasal mucus, eyeEyelid swelling, conjunctival congestion, there is slurries sexual secretion, after 1~2 day, in hairless position such as nares, face, ear, the back of the bodyPortion, thorax abdomen, four limbs have two points of block rash to a yuan coin-size without hair-fields, after rash block ulceration, there is weak yellow liquid streamGo out, after 3~4 days, absorbed gradually without the warts of ulceration, drying shrinkage, form brown scab.After in a few days, decrustation, loseThe thin scar of color is stayed to heal, overall process is 3~4 weeks.Goatpox can concurrently respiratory tract, disease of digestive tract and arthritis,It can cause pyaemia septica when serious and dead.In November, 2013, Sichuan Guangyuan city puts flock of sheep in a suitable place to breed and this disease occurs, with same sideWhat method took the effect of good control.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listedWith.It can be applied to various suitable the field of the invention completely., can be easily for those skilled in the artRealize other modification.Therefore it is of the invention and unlimited under the universal limited without departing substantially from claim and equivalency rangeIn specific details.

Claims (6)

CN201510129031.1A2015-03-232015-03-23Composition of medicine for preventing and treating animal aphtha hoof Huang and preparation method thereofActiveCN104784311B (en)

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CN105708960B (en)*2016-04-012018-07-03重庆市畜牧科学院 Traditional Chinese medicine composition for treating aphthous ulcer

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Publication numberPriority datePublication dateAssigneeTitle
CN104415184A (en)*2013-08-282015-03-18杜淑卿Compound aphtha powder

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* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CN104415184A (en)*2013-08-282015-03-18杜淑卿Compound aphtha powder

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* Cited by examiner, † Cited by third party
Title
中西医结合治疗山羊口疮病例;陈绍辉等;《中国兽医杂志》;20131231;第49卷(第5期);第85页*

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