This application claims Patent Office of the People's Republic of China, Application No. 201510108393.2, invention wound are submitted on March 12nd, 2015Make entitled " a kind of thrombectomby system ", and on March 12nd, 2015 submits Patent Office of the People's Republic of China, Application No.201520141175.4th, invention and created name is a kind of priority of the Chinese patent application of " thrombectomby system ", its wholeContent is hereby incorporated by reference in the application.
The content of the invention
In view of this, the invention provides a kind of thrombectomby system, its thrombectomy device is very soft, can easily enterThe cerebrovascular；The near-end of the thrombectomby system has good push and twisting property, and distal end is softer, and pliability is good, Neng GouFreely conveyed in complicated cardiovascular and cerebrovascular, it is to avoid injured blood vessel.
To achieve the above object, the present invention provides following technical scheme：
A kind of thrombectomby system, including thrombectomy device, conveying microtubular and balloon guide catheter；
The thrombectomy device is slidably arranged in the conveying microtubular, is slidably set in the conveying microtubularIn the balloon guide catheter；
The hardness of the conductive filament head of distal end is less than the hardness of the pipe shaft of the balloon guide catheter in the thrombectomy device.
It is preferred that, the thrombectomy device includes：
Thread core filaments；
The coaxially connected conductive filament head in the core filaments distal end；
The excision spring of the conductive filament head near-end is arranged on, the excision spring and the core filaments are coaxial, the two, which is formed, slidesDynamic contact connection, the Spontaneous release state of the excision spring is conical helical pattern, can be placed in that the conveying is micro- to be led after contractionIn pipe；
It is arranged on the indicating of the excision spring near-end；
It is arranged in the core filaments, and positioned at the limiter of the excision spring inner, the limiter is used to limit instituteState sliding scale of the excision spring in the core filaments.
It is preferred that, the conductive filament head uses a diameter of 0.03~0.20mm platinum wire, platinum alloy silk, golden alloy wire, tungstenCoil spring shape is made in silk or stainless steel wire, and its external diameter is 0.20~0.97mm, and length is not more than 50mm.
It is preferred that, the excision spring is made of platinum core titanium-nickel wire or golden core titanium-nickel wire；Or use common NiTiCoil spring shape skeleton is made in B alloy wire, then coats one layer of platinum wire, platinum alloy silk, golden alloy wire or tungsten filament spring；
The string diameter of the excision spring is 0.025~0.15mm, and quantity is 1~16, and pitch is 0.5~3mm, spiral coilNumber is 2~6 circles, and maximum gauge is 2~10mm.
It is preferred that, the pipe shaft segmentation of the balloon guide catheter is using the material of different hardness, and its hardness is vertically by nearThe classification of end to distal end softens gradually.
It is preferred that, the pipe shaft segmentation of the conveying microtubular is using the material of different hardness, and its hardness is vertically by near-endSoften gradually to distal end classification.
It is preferred that, the balloon guide catheter includes：
Pipe shaft；
It is arranged on the indicating of the pipe shaft distal end；
It is arranged on the pipe shaft, and positioned at the sacculus of the indicating near-end；
It is connected to the seat of the pipe shaft near-end；
It is arranged on the strain relief sleeve pipe of the pipe shaft and the seat junction.
It is preferred that, the pipe shaft of the balloon guide catheter is three-decker, and internal layer uses polytetrafluoroethylene (PTFE), and intermediate layer is steelSilk screen, helical spring or steel wire+helical spring, outer layer use nylon, nylon elastomer or polyurethane.
It is preferred that, the conveying microtubular includes：
Pipe shaft；
It is arranged on the indicating of the pipe shaft distal end；
It is connected to the seat of the pipe shaft near-end；
It is arranged on the strain relief sleeve pipe of the pipe shaft and the seat junction.
It is preferred that, the pipe shaft of the conveying microtubular is three-decker, and internal layer uses polytetrafluoroethylene (PTFE), and intermediate layer is steel wireNet, helical spring or steel wire+helical spring, outer layer use nylon, nylon elastomer or polyurethane.
It can be seen from above-mentioned technical scheme that, the thrombectomby system that the present invention is provided, its thrombectomy device is very softSoft, the hardness of the conductive filament head of distal end therein is less than the hardness of the pipe shaft of balloon guide catheter；So, thrombectomy device canEasily enter the cerebrovascular；The near-end of the thrombectomby system has good push and twisting property, softer, the pliability in distal endIt is good, can freely it be conveyed in complicated cardiovascular and cerebrovascular, it is to avoid injured blood vessel.
Embodiment
The invention discloses a kind of thrombectomby system, its thrombectomy device is very soft, can easily enter the cerebrovascular；ShouldThe near-end of thrombectomby system has good push and twisting property, and distal end is softer, and pliability is good, can be in complicated heart and brainIt is intravascular freely to convey, it is to avoid injured blood vessel.
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, completeSite preparation is described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.It is based onEmbodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not madeEmbodiment, belongs to the scope of protection of the invention.
Fig. 1-Fig. 4 is referred to, Fig. 1 is the structural representation of thrombectomy device provided in an embodiment of the present invention；Fig. 2 is this hairThe structural representation for the balloon guide catheter that bright embodiment is provided；Fig. 3 is the knot provided in an embodiment of the present invention for conveying microtubularStructure schematic diagram；Fig. 4 is the use figure of thrombectomby system provided in an embodiment of the present invention.
Thrombectomby system provided in an embodiment of the present invention, its core improvement is, including thrombectomy device 16, conveyingMicrotubular 18 and balloon guide catheter 19；
Thrombectomy device 16 is slidably arranged on 18 in conveying microtubular, and both form sliding contact；Convey in microtubular18 are slidably arranged in balloon guide catheter 19, and both form sliding contact；Wherein, conveying microtubular 18 is used to cut thrombusExcept device 16 be delivered to target blood 15 and operation end drop back out in vitro；Balloon guide catheter 19 is used for Basilar artery blood flow,Set up near-end protection；
The hardness of the conductive filament head 1 of distal end is less than the hardness of the pipe shaft 8 of balloon guide catheter 19 in thrombectomy device 16 so thatThe hardness of thrombectomby system is softened gradually by near-end to distal end classification vertically；It should be noted that above-mentioned distal end is baseIt is accordingly, close in the use state of thrombectomby system, the i.e. one end of the apparatus away from user, i.e. left end in accompanying drawingOne end of user is the right-hand member in near-end, i.e. accompanying drawing, similarly hereinafter.
As Figure 1-Figure 4, when using thrombectomby system provided in an embodiment of the present invention, the quilt of balloon guide catheter 19The near-end of embolism position 17 is delivered to, Filled Balloon 7, Basilar artery blood flow sets up near-end protection.Will be defeated through balloon guide catheter 19Send microtubular 18 to be delivered to embolism position distal end with thrombectomy device 16, keep the position of thrombectomy device 16 constant, withdraw conveyingMicrotubular 18, the excision spring 2 of thrombectomy device 16 is discharged in embolism position distal end, is now cut off spring 2 and is opened naturally, withdrawsThrombectomy device 16, thrombus is dragged in balloon guide catheter 19, accomplished the end in view.
It can be seen from above-mentioned technical scheme that, thrombectomby system provided in an embodiment of the present invention, its thrombectomy deviceVery soft, the hardness of the conductive filament head of distal end therein is less than the hardness of the pipe shaft of balloon guide catheter；So, thrombus is cutExcept device can easily enter the cerebrovascular；The hardness of the thrombectomby system is softened gradually by near-end to distal end classification vertically, near-endWith good push and twisting property, distal end is softer, and pliability is good, can freely convey, keep away in complicated cardiovascular and cerebrovascularExempt from injured blood vessel.
In the specific embodiment that this programme is provided, thrombectomy device 16 includes：
Thread core filaments 5；Preferably, core filaments 5 are made of nitinol alloy wire or stainless steel wire, string diameter is 0.25~0.97mm, length is 500~3000mm；
The coaxially connected conductive filament head 1 in the distal end of core filaments 5；
The excision spring 2 of the near-end of conductive filament head 1 is arranged on, excision spring 2 and core filaments 5 are coaxial, cut off the near-end and core of spring 2Silk 5 is formed and is slidably connected, and (tip of excision spring 2 is towards core filaments 5 for conical helical pattern for the Spontaneous release state of excision spring 2Distal end), can be placed in after contraction conveying microtubular 18 in；
It is arranged on the indicating 3 of the excision near-end of spring 2；Preferably, the external diameter of indicating 3 is 0.2~0.97mm, using platinum, platinumAlloy, gold or stainless steel, are connected with excision spring 3 by welding technique, the position of excision spring 2 can be shown under X-ray, thisWhen the overall X-ray opaque of excision spring 2；
It is arranged in core filaments 5, and positioned at the limiter 4 cut off inside spring 2, limiter 4 exists for limiting excision spring 2Sliding scale in core filaments 5, its structure is referred to described in Fig. 1.
Preferably, platinum wire, platinum alloy silk, golden alloy wire, tungsten filament of the conductive filament head 1 using a diameter of 0.03~0.20mmOr coil spring shape is made in stainless steel wire etc., its external diameter is 0.20~0.97mm, and length is not more than 50mm, preferably 3-20mm,Certain toughness is also assures that on the premise of structurally flexible.
In the specific embodiment that this programme is provided, excision spring 2 is made of platinum core titanium-nickel wire or golden core titanium-nickel wire；Or coil spring shape skeleton is made using common nitinol alloy wire, then coat one layer of platinum wire, platinum alloy silk, golden alloy wire orTungsten filament spring, the overall X-ray opaque of the excision spring 2；
The string diameter for cutting off spring 2 is 0.025~0.15mm, and quantity is 1~16, and pitch is 0.5~3mm, spiral number of turnsFor 2~6 circles, maximum gauge is 2~10mm.
In order to further optimize above-mentioned technical scheme, the segmentation of pipe shaft 8 of balloon guide catheter 19 is using different hardnessMaterial, its hardness is softened gradually by near-end to distal end classification vertically.
Similar, the segmentation of pipe shaft 12 of conveying microtubular 18 is using the material of different hardness, and its hardness is vertically by near-endSoften gradually to distal end classification.The pipe shaft 8 of balloon guide catheter 19 is from conveying the segmentation of pipe shaft 12 of microtubular 18 using different hardThe polymeric material of degree, makes the hardness of pipe shaft be softened gradually by near-end to distal end classification vertically, near-end has good pushAnd twisting property, distally softer, pliability is good, can freely be conveyed in complicated cardiovascular and cerebrovascular, it is to avoid injured blood vessel.Enter oneStep, the hardness of pipe shaft 12 is less than the hardness of pipe shaft 8 in balloon guide catheter 19 in conveying microtubular 18.
In the specific embodiment that this programme is provided, balloon guide catheter 19 includes：
Pipe shaft 8；Preferably, its internal diameter is 0.84~1.02mm, external diameter is 1.0~1.20mm, long 100~140cm；
It is arranged on the indicating 6 of the distal end outer rim of pipe shaft 8；Preferably, the external diameter of indicating 6 is 0.70~0.90mm, using platinum, platinumAlloy, gold or stainless steel are material, are connected by welding procedure with the pipe shaft 8 of balloon guide catheter 19, can shown under X-rayShadow；
It is arranged on pipe shaft 8, and positioned at the sacculus 7 of the near-end of indicating 6, and sacculus 7 and conduit 8 are coaxial；When in use, pass throughSyringe fills contrast agent to realize that sacculus 7 is filled to the inner chamber of sacculus 7, and syringe is connected on catheter block 10；Preferably, ballCapsule 7 is made of silica gel or latex, and maximum fills a diameter of 3~20mm, and the length of sacculus 7 is 5~20mm；
The seat 10 of the near-end of pipe shaft 8 is connected to, its structure is referred to shown in Fig. 2；
It is arranged on the strain relief sleeve pipe 9 of pipe shaft 8 and the junction of seat 10；The strain relief sleeve pipe 9 is pipe shaft 8 and seat 10Transition, strain relief sleeve pipe 9 is covered in the proximal end face of pipe shaft 8, is firmly connected with pipe shaft 8, there is a through hole inside seat 10, with pipeThe inner chamber of body 8 is communicated.
Preferably, the pipe shaft 8 of balloon guide catheter 19 is three-decker, internal layer uses polytetrafluoroethylene (PTFE), interior when usingChamber can obtain less frictional resistance；Intermediate layer is steel wire, helical spring or steel wire+helical spring；Steel wire is to protectThrust is demonstrate,proved, helical spring ensures fracture resistance, can also increase X-ray observability；In the specific embodiment that this programme is provided, steel wireNet a diameter of 0.01~0.076mm stainless steels, tungsten or titanium-nickel wire, PPI are 25~100；Helical spring with diameter 0.01~0.076mm stainless steel, tungsten or titanium-nickel wire is made, and pitch is 0.012~0.1mm, and external diameter is 0.70~0.90m；Outer layer is usedNylon, nylon elastomer or polyurethane are material.
In order to further optimize above-mentioned technical scheme, balloon guide catheter 19 can be additionally used in aspirate thrombi.For largerEmbolus, also first can aspirate a part with balloon guide catheter 19 and take bolt thrombus, i.e., a syringe is connected on catheter block 10, is passed throughSyringe is aspirated, then takes out remaining thrombus with thrombectomy device 16, so as to realize that Biochemical analyzer takes bolt to be combined with machinery, is improvedSuccess rate of operation, reduces complication.
In the specific embodiment that this programme is provided, conveying microtubular 18 includes：
Pipe shaft 12；Preferably, its internal diameter is 0.43~0.69mm, external diameter is 0.58~0.84mm, long 140~160cm；
It is arranged on the indicating 11 of the distal end outer rim of pipe shaft 12；Preferably, the external diameter of indicating 11 is 0.48~0.74mm, usePlatinum, platinum alloy, gold or stainless steel are material, are connected by welding procedure with balloon guide catheter, can developed under X-ray；
It is connected to the seat 14 of the near-end of pipe shaft 12；
It is arranged on the strain relief sleeve pipe 13 of pipe shaft 12 and the junction of seat 14；The strain relief sleeve pipe 13 is pipe shaft 12 and seat14 transition, strain relief sleeve pipe 13 is covered in the proximal end face of pipe shaft 12, is firmly connected with pipe shaft 12, has one to lead to inside seat 14Hole, is communicated with the inner chamber of pipe shaft 12.
Preferably, the pipe shaft 12 of conveying microtubular 18 is three-decker, internal layer uses polytetrafluoroethylene (PTFE), inner chamber when usingLess frictional resistance can be obtained；Intermediate layer is steel wire, helical spring or steel wire+helical spring；There is provided in this programmeIn specific embodiment, steel wire a diameter of 0.01~0.06mm stainless steels, tungsten or titanium-nickel wire, PPI are 25~100.Spiral bulletSpring is made of 0.01~0.07mm of diameter stainless steel, tungsten or titanium-nickel wire, pitch be 0.012~0.1mm, external diameter be 0.48~0.74mm；Outer layer uses nylon, nylon elastomer or polyurethane for material.
Conveying microtubular 18 is placed in balloon guide catheter 19, can play enhancing support to balloon guide catheter 19 by insideEffect, is used to help the intravasation of balloon guide catheter 19 and in the blood vessels smooth conveying thrombectomy device 16.
In summary, thrombectomby system provided in an embodiment of the present invention, the technical problem to be solved is taken by machineryPin device takes out embolus, and dredging vascellum realizes revascularization.Taking can lead during bolt in embolism position near-end one ball capsule of placementPipe, interim block blood flow prevents the tiny broken embolus for taking bolt process to produce from rushing at blood vessel distal end by blood flow；Simultaneously for compared withBig embolus, also first can aspirate a part of thrombus, then take out remaining thrombus with thrombectomy device with balloon guide catheter.The present invention'sThrombectomby system is provided with thrombectomy device, balloon guide catheter and conveys microtubular, wherein, thrombectomy device is used as main groupPart, provided with excision spring, excision spring release conditions are conical helical pattern.The present invention compared with prior art, thrombectomy deviceVery soft, minimum is 0.014 by size, and " (0.36mm) can easily enter the cerebrovascular, surgical procedure is using near-end protection skillArt, Biochemical analyzer takes bolt to be combined with machinery, improves success rate of operation, reduces complication.
The embodiment of each in this specification is described by the way of progressive, and what each embodiment was stressed is and otherBetween the difference of embodiment, each embodiment identical similar portion mutually referring to.
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or using the present invention.A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined hereinGeneral Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, it is of the inventionThe embodiments shown herein is not intended to be limited to, and is to fit to and principles disclosed herein and features of novelty phase oneThe most wide scope caused.